Table III. Defined Daily Doses for Statistical Purposes (S-DDD) for Psychotropic Substances
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Table III. Defined daily doses for statistical purposes (S-DDD) for psychotropic substances The term “defined daily doses for statistical purposes (S-DDD)”, indicated defined daily doses for statistical purposes should be which has replaced the term “defined daily doses (DDD)”, is used considered approximate and subject to modifications if more by INCB as a technical unit of measurement for the purpose of precise information becomes available. The basis for the grouping statistical analysis and is not a recommended prescription dose. Its of the substances was, as far as possible, the anatomical definition is not free of a certain degree of arbitrariness. Certain therapeutic chemical (ATC) classification system used in the Nordic psychotropic substances may be used in certain countries for differ- Statistics on Medicines and recommended by the World Health ent treatments or in accordance with different medical practices, Organization (WHO) for drug utilization studies. In addition, the and therefore a different daily dose could be more appropriate. The grouping reflects the Schedules of the 1971 Convention. 25 Table III.1. Defined daily doses for statistical purposes (S-DDD) for psychotropic substances, by schedule Tableau III.1. Doses quotidiennes déterminées à des fins statistiques (S-DDD) pour les substances psychotropes, par tableau Cuadro III.1. Dosis diarias definidas con fines estadísticos (S-DDD) para las sustancias sicotrópicas, por lista S-DDD S-DDD (mg) (mg) Substances listed in Schedule II Amfepramone — Amfépramone — Anfepramona ......... 75.00 Substances inscrites au Tableau II Aminorex ......................................... — Sustancias incluidas en la Lista II Barbital .......................................... 500.00 Benzfetamine — Benzfétamine — Benzfetamina ......... 75.00 Amfetamine — Amfétamine — Anfetamina ............. 15.00 Bromazepam — Bromazépam ........................ 10.00 Amineptine — Amineptina ........................... — Brotizolam ........................................ 0.25 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) — Butobarbital ....................................... 150.00 4-Bromo-2,5-diméthoxyphénéthylamine — Camazepam — Camazépam .......................... 30.00 4-Bromo-2,5-dimetoxifenetilamina .................... — Chlordiazepoxide — Chlordiazépoxide — Clordiazepóxido .. 30.00 delta-9-Tetrahydrocannabinol and its stereochemical Clobazam ......................................... 20.00 variants — Clonazepam — Clonazépam .......................... 8.00 delta-9-Tétrahydrocannabinol et ses variantes Clorazepate — Clorazépate — Clorazepato. 20.00 stéréochimiques — Clotiazepam — Clotiazépam .......................... 15.00 delta-9-Tetrahidrocannabinol y sus variantes Cloxazolam ........................................ 9.00 estereoquímicas ............................... 30.00 Delorazepam — Délorazépam ......................... 3.00 Dexamfetamine — Dexamfétamine — Dexanfetamina ..... 15.00 Diazepam — Diazépam .............................. 10.00 Fenetylline — Fénétylline — Fenetilina ................. 50.00 Estazolam. 3.00 gamma-Hydroxybutyric acid (GHB)a — a Ethchlorvynol — Etclorvinol .......................... 500.00 Acide gamma-hydroxibutirique (GHB) — a Ethinamate — Éthinamate — Etinamato ................ 500.00 Ácido gamma-hidroxibutírico (GHB) ................. — Ethyl loflazepate — Loflazépate d’éthyle — Levamfetamine — Lévamfétamine — Levanfetamina ...... 15.00 Loflazepato de etilo ............................... 2.00 Levomethamphetamine — Lévométhamphétamine — Etilamfetamine — Étilamfétamine — Etilanfetamina ....... 30.00 Levometanfetamina ............................... 15.00 Fencamfamin — Fencamfamine — Fencanfamina ........ 80.00 Mecloqualone — Mécloqualone — Meclocualona ........ 200.00 Fenproporex ....................................... 20.00 Metamfetamine — Métamfétamine — Metanfetamina .... 15.00 Fludiazepam — Fludiazépam ......................... 0.75 Metamfetamine racemate — Flurazepam — Flurazépam ........................... 30.00 Racémate de métamfétamine — Halazepam — Halazépam ............................ 100.00 Racemato de metanfetamina ....................... 15.00 Haloxazolam ....................................... 7.50 Methaqualone — Méthaqualone — Metacualona ......... 200.00 Ketazolam — Kétazolam ............................. 30.00 Methylphenidate — Méthylphénidate — Metilfenidato ..... 30.00 Lefetamine (SPA) — Léfétamine (SPA) — Lefetamina (SPA). 75.00 Phencyclidine — Fenciclidina ......................... — Loprazolam ........................................ 1.00 Phenmetrazine — Phenmétrazine — Fenmetracina ........ 50.00 Lorazepam — Lorazépam ............................ 2.50 Secobarbital — Sécobarbital ......................... 100.00 Lormetazepam — Lormétazépam. 1.00 Zipeprol — Zipéprol ................................ 200.00 Mazindol ......................................... 1.00 Medazepam — Médazépam .......................... 20.00 Substances listed in Schedule III Mefenorex — Méfénorex ............................ 60.00 Substances inscrites au Tableau III Meprobamate — Méprobamate — Meprobamato ........ 1 200.00 Sustancias incluidas en la Lista III Mesocarb — Mésocarbe — Mesocarbo ................ 25.00 Methylphenobarbital — Méthylphénobarbital — Amobarbital ....................................... 100.00 Metilfenobarbital ................................. 100.00 b b b Buprenorphine — Buprénorphine — Buprenorfina ...... 8.00 Methyprylon — Méthyprylone — Metiprilona ............ 200.00 Butalbital ......................................... 75.00 Midazolam ........................................ 20.00 Cathine — Catina .................................. 20.00 Nimetazepam — Nimétazépam ....................... 5.00 Cyclobarbital — Ciclobarbital. 200.00 Nitrazepam — Nitrazépam ........................... 5.00 Flunitrazepam — Flunitrazépam ....................... 1.00 Nordazepam — Nordazépam ......................... 15.00 Glutethimide — Glutéthimide — Glutetimida ............ 250.00 Oxazepam — Oxazépam ............................. 50.00 Pentazocine — Pentazocina .......................... 200.00 Oxazolam ......................................... 40.00 Pentobarbital ...................................... 100.00 Pemoline — Pémoline — Pemolina .................... 40.00 Phendimetrazine — Phendimétrazine — Fendimetracina ... 70.00 Substances listed in Schedule IV Phenobarbital — Phénobarbital — Fenobarbital .......... 100.00 Substances inscrites au Tableau IV Phentermine — Fentermina .......................... 15.00 Sustancias incluidas en la Lista IV Pinazepam — Pinazépam ............................ 15.00 Pipradrol .......................................... 30.00 Allobarbital — Alobarbital ............................ 100.00 Prazepam — Prazépam .............................. 30.00 Alprazolam ........................................ 1.00 Pyrovalerone — Pyrovalérone — Pirovalerona ........... 40.00 27 Table III.1. Defined daily doses for statistical purposes (S-DDD) for psychotropic substances, by schedule (continued) Tableau III.1. Doses quotidiennes déterminées à des fins statistiques (S-DDD) pour les substances psychotropes, par tableau (suite) Cuadro III.1. Dosis diarias definidas con fines estadísticos (S-DDD) para las sustancias sicotrópicas, por lista (continuación) S-DDD S-DDD (mg) (mg) Secbutabarbital .................................... 75.00 Triazolam ......................................... 0.25 Temazepam — Témazépam .......................... 20.00 Vinylbital — Vinilbital ............................... 150.00 Tetrazepam — Tétrazépam ........................... 100.00 Zolpidem ......................................... 10.00 a By its decision 56/1, the Commission decided to transfer gamma-hydroxybutyric acid from Schedule IV to Schedule II of the Convention on Psychotropic Substances of 1971. In accordance with article 2, paragraph 7 of that Convention, the decision became fully effective with respect to each Party on 4 December 2013. — Par sa décision 56/1, la Commission des stupéfiants a décidé de transférer l’acide gamma-hydroxibutirique (GHB) du Tableau IV au Tableau II de la Convention de 1971 sur les substances psychotropes. Conformément au paragraphe 7 de l’article 2 de cette Convention, la décision a pris pleinement effet pour chaque Partie le 4 décembre 2013. — En virtud de la decisión 56/1, la Comisión decidió transferir el ácido gamma-hidroxibutírico de la Lista IV a la Lista II del Convenio sobre Sustancias Sicotrópicas de 1971. De conformidad con el artículo 2, párrafo 7, de ese Convenio, la decisión entró en vigor plenamente respecto de cada una de las Partes el 4 de diciembre de 2013. b In the past, the Board calculated one S-DDD to be equal to 1.2 mg of buprenorphine, a measure that reflected the dosage units used for treatment of pain in the late 1990s. In view of the increasing use of higher dosage units of buprenorphine for the treatment of pain and opioid dependence, the Board decided to calculate, as of 2010, one S-DDD to be equal to 8 mg of buprenorphine. Data on buprenorphine expressed in S-DDD in this publication are therefore not comparable with the corresponding data shown for previous years. — Par le passé, l’OICS se fondait, pour la buprénorphine, sur une S-DDD de 1,2 mg, ce qui correspondait à la dose utilisée pour le traitement de la douleur à la fin des années 90. Considérant l’emploi de plus en plus fréquent de doses supérieures pour le traitement de la douleur et de la dépendance aux opioïdes,