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Appendix 1 Cross-Reference of Research, Generic and Trade Names of Benzodiazepines

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Appendix 1 Cross-Reference of Research, Generic and Trade Names of Benzodiazepines Table 1. Benzodiazepine research designations with corresponding generic names Research Designation Generic Name lactam demoxepam methyloxazepam temazepam A 101 nordazepam AB 35616 clorazepate AB 39083 clorazepate AH 3232 clorazepate CB 4261 tetrazepam CB 4306 clorazepate CB 4311 clorazepate CGS 8216 (antagonist) CI683 ripazepam CS 370 cloxazolam CS 430 haloxazolam D40TA estazolam EGYT 341 tofisopam ER 115 temazepam HR 158 loprazolam HR376 clobazam HR 4723 clobazam HR930 fosazepam K3917 temazepam 287 THE BENZODIAZEPINES Research Designation Generic Name LA 111 diazepam LM 2717 clobazam ORF 8063 triflubazam Ro 4-5360 nitrazepam Ro 5-0690 chlordiazepoxide Ro 5-0883 desmethy1chlordiazepoxide Ro 5-2092 demoxepam Ro 5-2180 desmethyldiazepam Ro 5-2807 diazepam Ro 5-2925 desmethylmedazepam Ro 5-3059 nitrazepam Ro 5-3350 bromazepam Ro 5-3438 fludiazepam Ro 5-4023 clonazepam Ro 5-4200 flunitrazepam Ro 5-4556 medazepam Ro 5-5345 temazepam Ro 5-6789 oxazepam Ro 5-6901 flurazepam Ro 15-1788 (antagonist) Ro 21-3981 midazolam RU 31158 loprazolam S 1530 nimetazepam SAH 1123 isoquinazepam SAH 47603 temazepam SB 5833 camazepam SCH 12041 halazepam SCH 16134 quazepam U 28774 ketazolam U 31889 alprazolam U 33030 triazolam W4020 prazepam We 352 triflubazam 288 RESEARCH, GENERIC AND TRADE NAMES Research Designation Generic Name We 941 brotizolam Wy 2917 temazepam Wy 3467 diazepam Wy 3498 oxazepam Wy 3917 temazepam Wy 4036 lorazepam Wy 4082 lormetazepam Wy 4426 oxazepam Y 6047 ciotiazepam Table 2. Benzodiazepine generic names with corresponding trade names Generic Name Trade Name(s) alprazolam Xanax bromazepam Compendium, Lectopam, Lexatin, Lexomil, Lexotan, Lexotanil brotizolam Lendorm, Lendormin camazepam Albego, Limpidon, Paxor chlordiazepoxide Ansiacal, A-Poxide, Benzodiapin, Binomil, Cebrum, Chlortran, Corax, C-Tran, Decacil, Diazepina, Disarim, Eden-psich, Endequil, Elenium, Equibral, Helogaphen, Huberplex, Klopoxid, Labican, Liberans, Librium, Libritabs, Lixin, Medilium, Menrium, Mesural, Multum, Nack, Normide, Novopoxide, O.CM., Omnalio, Philicorium, Psicofar, Psicoterina, Raysedan, Reposal, Relaxil, Reliberan, Risachief, Risolid, Seren, Silibrin, Sintesedan, Smail, Solium, SonimenTrilium, Tropium, Viansin, Zeisin, Zetran c10bazam Castilium, Frisin, Frisium, Karidium, Noiafren, Sentil, Urbadan, Urbanol, Urbanyl 289 THE BENZODIAZEPINES Generic Name Trade Name(s) clonazepam Clonopin, Iktorivil, Landsen, Rivotril clorazepate Azene, Belseren, Covengar, Enadine, Justum, Mendon, Moderane, Nansius, Tencilan, Transene, Tranxen, Tranxene, Tranxilen, Tranxilene, Tranxilium, Uni-Tranxene clorazolam see triazolam clotiazepam Rize, Trecalmo cloxazolam Enadel, Lubalix, OIcadil, Sepazon, Tolestan diazepam Aliseum, Alupram, Amiprol, Ansiolin, Apaurin, Apozepam, Armonil, Atenex, Atensine, Atilen, Avex, Best, Bialzepam, Calmpose, Ceregulart, Cuadel, Cyclopam, Diaceplex, Diapam, Diatran, Diazemuls, Dipam, Dipezona, Dizam, Doval, Drenian, D-Tran, Ducene, E-Pam, Eridan, Euphorin, Evacalm, Faustan, Gradual, Gubex, Lembrol, Levium, Lorinon, Meval, Morostan, Neo-Calme, Neurolytril, Noan, Notense, Novodipam, Pacitran, Pax, Paxate, Paxel, Plidan, Pro-pam, Quetinil, Quievita, Relanium, Relivan X, Saromet, Scriptopam, Sedapam, Sedaril, Seduxen, Serenack, Setonil, Solis, Somasedan, Sonacon, Stesolid, Stesolin, Stess-Pam, Tensium, Tranimul, Tranquase, Tranquirit, Tranquo-Tablinen, Valitran, Valium, Valrelease, Vatran, Vival, Vivol estazolam Domnamid, Esilgan, Eurodin, Nuctalon fiudiazepam Erispan fiunitrazepam Darkene, Narcozep, Primun, Rohipnol, Rohypnol, Roipnal, Val sera 290 RESEARCH, GENERIC AND TRADE NAMES Generic Name Trade Name(s) flurazepam Benozil, Dalmane, Dalmadorm, Dalmate, Domodor, Dormodor, Felison, Felmane, Flunox, Fordrim, Insumin, Lunipax, Midorm AR, Natam, Niotal, Remdue, Somlan, Valdorm flutazolam Coreminal halazepam Paxipam haloxazolam Some lin ketazolam Anxon, Contamex, Loftran, Solatran, Unakalm loprazolam Avlane, Dormonoet lorazepam Almazine, Aplaeasse, Ativan, Control, Emotieal, Emotival, Kalmalin, Loraus, Lorax, Lorsilan, Lorenin, NIC, Orfidal, Plaeidia, Psieopax, Quait, Seeurit, Sedarkey, Sedatival, Sidenar, Tavor, Temesta, Trapax, Wypax lormetazepam Loramet, Noetamid medazepam Ansilan, Anxitol, Azepamid, Benson, Diepin, Elbrus, Esmail, Lerisum, Medazepol, Megasedan, Metonas, Mezepan, Narsis, Navizil, Nivelton, Nobrium, Pazital, Psiquium, Raporan, Resmit, Rudotel, Serenium, Siman, Templane, Tranquilax mexazolam Melex midazolam Dormieum nimetazepam Elimin, Erimin, Hypnon 291 THE BENZODIAZEPINES Generic Name Trade Name(s) nitrazepam Apodorm, Arem, Benzalin, Calsmin, Dormicum, Dumolid, Eatan, Eunoctin, Hipsal, Hypnotin, Mitidin, Mogadan, Mogadon, Nelbon, Neuchlonic, Nipam, Nitrados, Nitrenpax, Noctene, Pacisyn, Paxisyn, Pelson, Persopir, Prosonno, Quill, Radedorm, Relact, Remnos, Sindepres, Somnased, Somnibel, Somnite, Sonebon, Sonnolin, Surem, Unisomnia nordazepam Calmday, Demadar, Madar, Stilny oxazepam Adumbran, Aplakil, Benzotran, Enidrel, Isodin, Limbial, Murelax, Nesontil, Nulans, Oxadin, Oxepam, Praxiten, Psiquiwas, Purata, Quen, Quilibrex, Sedokin, Serax, Serenal, Serenid-D, Serenid Forte, Serepax, Seresta, Serpax, Sobile, Sobril, Wakazepam oxazolam Convertal, Hializan, Serenal Tranquit oxazolazepam see oxazolam pinazepam Domar, Duna prazepam Centrax, Demetrin, Equipaz, Lysanxia, Mono Demetrin, Prazene, Reapam, Sedapran, Trepidan, Verstran temazepam Cerepax, Euhypnos, Lenal, Levanxene, Levanxol, Mabertin, Maeva, Normison, Planum, Remestan, Restoril, Signopam tetrazepam Clinoxan, Musaril, Myolastan tofisopam Grandaxin, Grandaxine, Seriel tofizopam see tofisopam triazolam Halcion 292 RESEARCH, GENERIC AND TRADE NAMES Table 3. Benzodiazepine trade names with corresponding generic names Trade Name Generic Name Adumbran oxazepam Albego camazepam Aliseum diazepam Almazine lorazepam Alupram diazepam Amiprol diazepam Ansiacal chlordiazepoxide Ansilan medazepam Ansiolin diazepam Anxitol medazepam Anxon ketazolam Apaurin diazepam Aplacasse lorazepam Aplakil oxazepam Apodorm nitrazepam A-Poxide chlordiazepoxide Apozepam diazepam Arem nitrazepam Armonil diazepam Atenex diazepam Atensine diazepam Atilen diazepam Ativan lorazepam Avex diazepam Avlane loprazolam Azene c!orazepate Azepamid medazepam Belseren c!orazepate Benozil flurazepam Benson medazepam Benzalin nitrazepam 293 THE BENZODIAZEPINES Trade Name Generic Name Benzodiapin chlordiazepoxide Benzotran oxazepam Best diazepam Bialzepam diazepam Binomil chlordiazepoxide Calmday nordazepam Calmpose diazepam Calsmin nitrazepam Castilium c!obazam Cebrum chlordiazepoxide Centrax prazepam Ceregulart diazepam Cerepax temazepam Chlortran chlordiazepoxide Clinoxan tetrazepam Clonopin c!onazepam Compendium bromazepam Contamex ketazolam Control lorazepam Convertal oxazolam Corax chlordiazepoxide Coreminal fiutazolam Covengar c!orazepate C-Tran chlordiazepoxide Cuadel diazepam Cyc!opam diazepam Dalmane fiurazepam Dalmadorm fiurazepam Dalmate fiurazepam Darkene fiunitrazepam Decacil chlordiazepoxide Demadar nordazepam Demetrin prazepam 294 RESEARCH, GENERIC AND TRADE NAMES Trade Name Generic Name Diaceplex diazepam Diapam diazepam Diatran diazepam Diazemuls diazepam Diazepina chlordiazepoxide Diepin medazepam Dipam diazepam Dipezona diazepam Disarim chlordiazepoxide Domar pinazepam Domnamid estazolam Domordor flurazepam Dormicum midazolam, nitrazepam Dormodor flurazepam Dormonoct loprazolam Doval diazepam Drenian diazepam D-Tran diazepam Ducene diazepam Dumolid nitrazepam Duna pinazepam Eatan nitrazepam Eden-psich chlordiazepoxide Edenquil chlordiazepoxide Elbrus medazepam Elenium chlordiazepoxide Elimin nimetazepam Emotical lorazepam Emotival lorazepam Enadel cloxazolam Enadine clorazepate Enidrel oxazepam E-Pam diazepam 295 THE BENZODIAZEPINES Trade Name Generic Name Equibral chlordiazepoxide Equipaz prazepam Eridan diazepam Erimin nimetazepam Erispan fludiazepam Esilgan estazolam Esmail medazepam Euhypnos temazepam Eunoctin nitrazepam Euphorin diazepam Eurodin estazolam Evacalm diazepam Faustan diazepam Feliston flurazepam Felmane flurazepam Flunox flurazepam Fordrim flurazepam Frisin c10bazam Frisium c10bazam Gradual diazepam Grandaxin tofisopam Grandaxine tofisopam Gubex diazepam Ha1cion triazolam Helogaphen chlordiazepoxide Hializan oxazolam Hipsal nitrazepam Huberplex chlordiazepoxide Hypnon nimetazepam Hypnotin nitrazepam Iktorivil c10nazepam Insumin flurazepam Isodin oxazepam 296 RESEARCH, GENERIC AND TRADE NAMES Trade Name GenericName Justum c10razepate Kalmalin lorazepam Karidium c10bazam Klopoxid chlordiazepoxide Labican chlordiazepoxide Landsen c10nazepam Lectopam bromazepam Lembrol diazepam Lenal temazepam Lendorm brotizolam Lendormin brotizolam Lerisum medazepam Levanxene temazepam Levanxol temazepam Levium diazepam Lexatin bromazepam Lexomil bromazepam Lexotan bromazepam Lexotanil bromazepam Liberans chlordiazepoxide Limbial oxazepam Librium chlordiazepoxide Libritabs chlordiazepoxide Limpidon camazepam Lixin chlordiazepoxide Loftran ketazolam Loramet lormetazepam Loraus lorazepam Lorax lorazepam Lorinon diazepam Lorsilan lorazepam Lorenin lorazepam Lubalix c1oxazolam 297 THE BENZODIAZEPINES Trade Name GenericName Lunipax flurazepam Lysanxia prazepam Mabertin temazepam Madar nordazepam Maeva temazepam Medazepol medazepam Medilium chlordiazepoxide Megasedan medazepam Melex mexazolam Mendon clorazepate Menrium chlordiazepoxide Mesural chlordiazepoxide Metonas medazepam Meval diazepam Mezepan medazepam Midorm
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    Molecular Pharmacology Fast Forward. Published on November 4, 2005 as DOI: 10.1124/mol.105.017236 Molecular PharmacologyThis article hasFast not Forward.been copyedited Published and formatted. on The November final version 7, may 2005 differ as from doi:10.1124/mol.105.017236 this version. MOLPHARM/2005/017236 Pharmacological properties of GABAA- receptors containing gamma1- subunits Khom S.1, Baburin I.1, Timin EN, Hohaus A., Sieghart W., Hering S. Downloaded from Department of Pharmacology and Toxicology, University of Vienna Center of Brain Research , Medical University of Vienna, Division of Biochemistry and molpharm.aspetjournals.org Molecular Biology at ASPET Journals on September 27, 2021 1 Copyright 2005 by the American Society for Pharmacology and Experimental Therapeutics. Molecular Pharmacology Fast Forward. Published on November 4, 2005 as DOI: 10.1124/mol.105.017236 This article has not been copyedited and formatted. The final version may differ from this version. MOLPHARM/2005/017236 Running Title: GABAA- receptors containing gamma1- subunits Corresponding author: Steffen Hering Department of Pharmacology and Toxicology University of Vienna Althanstrasse 14 Downloaded from A-1090 Vienna Telephone number: +43-1-4277-55301 Fax number: +43-1-4277-9553 molpharm.aspetjournals.org [email protected] Text pages: 29 at ASPET Journals on September 27, 2021 Tables: 2 Figures: 7 References: 26 Abstract: 236 words Introduction:575 words Discussion:1383 words 2 Molecular Pharmacology Fast Forward. Published on November 4, 2005 as DOI: 10.1124/mol.105.017236 This article has not been copyedited and formatted. The final version may differ from this version. MOLPHARM/2005/017236 Abstract GABAA receptors composed of α1, β2, γ1-subunits are expressed in only a few areas of the brain and thus represent interesting drug targets.
  • Meta-Analysis of Benzodiazepine Use in the Treatment of Insomnia

    Meta-Analysis of Benzodiazepine Use in the Treatment of Insomnia

    Meta-analysis of benzodiazepine use in the treatment of insomnia Review Anne M. Holbrook, Renée Crowther, Ann Lotter, Chiachen Cheng, Derek King Synthèse Abstract From the Centre for Evaluation of Medicines, Objective: To systematically review the benefits and risks associated with the use St. Joseph’s Hospital of benzodiazepines to treat insomnia in adults. and McMaster University, Data sources: MEDLINE and the Cochrane Controlled Trials Registry were Hamilton, Ont. searched for English-language articles published from 1966 to December 1998 that described randomized controlled trials of benzodiazepines for the treatment This article has been peer reviewed. of insomnia. Key words included “benzodiazepines” (exploded), “randomized controlled trial” and “insomnia.” Bibliographies of relevant articles were re- CMAJ 2000;162(2):225-33 viewed for additional studies and manufacturers of benzodiazepines were asked to submit additional randomized controlled trial reports not in the literature. ß An overview of the diagnosis and management of insomnia in clinical Study selection: Articles were considered for the meta-analysis if they were ran- practice appears on page 216. domized controlled trials involving patients with insomnia and compared a ben- zodiazepine with placebo or another active agent. Of the 89 trials originally identified, 45 met our criteria, representing a total of 2672 patients. January 25, 2000 Data extraction: Data were extracted regarding the participants, the setting, details Table of Contents of the intervention, the outcomes (including adverse effects) and the method- ologic quality of the studies. Data synthesis: The meta-analyses of sleep records indicated that, when compared with placebo, benzodiazepines decreased sleep latency by 4.2 minutes (non- significant; 95% confidence interval [CI] –0.7 to 9.2) and significantly increased total sleep duration by 61.8 minutes (95% CI 37.4 to 86.2).
  • Comparative Efficacy and Acceptability of Pharmacological Treatments for Insomnia in Adults: a Systematic Review and Network Meta-Analysis (Protocol)

    Comparative Efficacy and Acceptability of Pharmacological Treatments for Insomnia in Adults: a Systematic Review and Network Meta-Analysis (Protocol)

    Cochrane Database of Systematic Reviews Comparative efficacy and acceptability of pharmacological treatments for insomnia in adults: a systematic review and network meta-analysis (Protocol) De Crescenzo F, Foti F, Ciabattini M, Del Giovane C, Watanabe N, Sañé Schepisi M, Quested DJ, Cipriani A, Barbui C, Amato L De Crescenzo F, Foti F, Ciabattini M, Del Giovane C, Watanabe N, Sañé Schepisi M, Quested DJ, Cipriani A, Barbui C, Amato L. Comparative efficacy and acceptability of pharmacological treatments for insomnia in adults: a systematic review and network meta-anal- ysis. Cochrane Database of Systematic Reviews 2016, Issue 9. Art. No.: CD012364. DOI: 10.1002/14651858.CD012364. www.cochranelibrary.com Comparative efficacy and acceptability of pharmacological treatments for insomnia in adults: a systematic review and network meta- analysis (Protocol) Copyright © 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. TABLE OF CONTENTS HEADER....................................... 1 ABSTRACT ...................................... 1 BACKGROUND .................................... 1 OBJECTIVES ..................................... 4 METHODS ...................................... 4 Figure1. ..................................... 5 ACKNOWLEDGEMENTS . 9 REFERENCES ..................................... 10 APPENDICES ..................................... 14 WHAT’SNEW..................................... 18 CONTRIBUTIONSOFAUTHORS . 18 DECLARATIONSOFINTEREST . 18 Comparative efficacy and acceptability of pharmacological treatments for
  • Effects of Brotizolam, a New Thieno-Triazolo-Diazepine Derivative, on the Central Nervous System

    Effects of Brotizolam, a New Thieno-Triazolo-Diazepine Derivative, on the Central Nervous System

    In the present study, its actions on the central nervous system were investigated. Effects of Brotizolam, a New Thieno-Triazolo-Diazepine Derivative, on the Central Nervous System Kenjiro KIMISHIMA, Kyoko TANABE, Yukako KINOSHITA, Kooji TOKUYOSHI, Daisuke HOURI and Tatsuo KOBAYASHI Department of Pharmacology, Tottori University School of Medicine, Yonago 683, Japan Accepted August 24, 1984 Abstract-The effects of brotizolam, a new thieno-triazolo-diazepine derivative, on the central nervous system were analyzed in mice, rats and rabbits. Diazepam, estazolam and triazolam were used as control drugs. Brotizolam inhibited spon taneous motor activities; performances in the rotarod test, staircase test, and maximal electroshock seizure test; and pentetrazol or bemegride-induced convulsion. Moreover, catalepsy inducing action and potentiating effect on sleep elicited by pentobarbital or ethanol were observed. Following intraperitoneal or oral admin istration of brotizolam to rabbits with chronically implanted electrodes , the electro encephalographic profile in spontaneous EEG was characterized by slow waves with high amplitudes in the neocortex. The arousal responses by stimulation of the midbrain reticular formation and posterior hypothalamus were slightly inhibited, but the recruiting responses induced by stimulation of the diffuse thalamic projecting system were not inhibited, and seizure discharges induced by stimulation of the dorsal hippocampus were inhibited markedly. When motor activities and pente trazol-induced convulsions were observed as indices of tolerance for brotizolam, tolerance was not developed by repeated administration of brotizolam up to 14 days. These results suggested that brotizolam, a new thieno-triazolo-diazepine derivative, is judged to be a safer and stronger sleep inducer than diazepam and estazolam . Since the pioneering paper by Randall et et al.