US 20090005722A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0005722 A1 Jennings-Spring (43) Pub. Date: Jan. 1, 2009

(54) SKIN-CONTACTING-ADHESIVE FREE Publication Classification DRESSING (51) Int. Cl. Inventor: Barbara Jennings-Spring, Jupiter, A61N L/30 (2006.01) (76) A6F I3/00 (2006.01) FL (US) A6IL I5/00 (2006.01) Correspondence Address: AOIG 7/06 (2006.01) Irving M. Fishman AOIG 7/04 (2006.01) c/o Cohen, Tauber, Spievack and Wagner (52) U.S. Cl...... 604/20: 602/43: 602/48; 4771.5; Suite 2400, 420 Lexington Avenue 47/13 New York, NY 10170 (US) (57) ABSTRACT (21) Appl. No.: 12/231,104 A dressing having a flexible sleeve shaped to accommodate a Substantially cylindrical body portion, the sleeve having a (22) Filed: Aug. 29, 2008 lining which is substantially non-adherent to the body part being bandaged and having a peripheral securement means Related U.S. Application Data which attaches two peripheral portions to each other without (63) Continuation-in-part of application No. 1 1/434,689, those portions being circumferentially adhered to the sleeve filed on May 16, 2006. portion.

Patent Application Publication Jan. 1, 2009 Sheet 1 of 9 US 2009/0005722 A1

Patent Application Publication Jan. 1, 2009 Sheet 2 of 9 US 2009/0005722 A1

10 8 F.G. 5 Patent Application Publication Jan. 1, 2009 Sheet 3 of 9 US 2009/0005722 A1

13 FIG.6 2 -

Y TIII Till "T fift

11 10 FIG.7

8 13 6 - 12 -

Timir" "in "in "MINIII. TITUTI. EIILITIL Patent Application Publication Jan. 1, 2009 Sheet 4 of 9 US 2009/0005722 A1

Patent Application Publication Jan. 1, 2009 Sheet 5 of 9 US 2009/0005722 A1

1 6 14 - : "TITFIII, IIITU

Patent Application Publication Jan. 1, 2009 Sheet 6 of 9 US 2009/0005722 A1

6 FIG.14B Patent Application Publication Jan. 1, 2009 Sheet 7 of 9 US 2009/0005722 A1

FIG.15B

F.G. 16 10 Patent Application Publication Jan. 1, 2009 Sheet 8 of 9 US 2009/0005722 A1

12 7 1

II. aI 13JNTT TLE (ET =- P TIII.

III IIIEE Patent Application Publication Jan. 1, 2009 Sheet 9 of 9 US 2009/0005722 A1

410 40O

FIG.2O

US 2009/0005722 A1 Jan. 1, 2009

11 in central region 8. When flap portions 6 and 7 are dis 16 (such as after circumcision). As shown, the device has been placed centrally inward, top portion 9 and bottom portion 10 applied to the penis, and right and left flaps 6 and 7 pulled can be displaced from one another such as shown in FIG. 8 to together so as to allow securing means 12 and 13 to mate and open sleeve 111 in anticipation of applying the device to an secure the device. FIG. 14 B shows the same arrangement as appropriate body or plant part. Securement means 12 and 13 FIG. 14A except that a drainage member 35 (preferably a are placed so that once the device is placed on the body or mesh fabric material) is also present, which is affixed to plant part, the peripheral ends of flaps 6 and 7 (distal from portion 10 in any suitable manner, such as by stitching 36. The central portion 8) can be grasped and brought together so that orientation and shape of drainage member 35 is not critical securement means 12 and 13 are substantially mated to one and many other variations will be appreciated by those of another (face to face) and result in securing the device in place ordinary skill. While drainage member 35 helps to isolate the without adhering to central portion 8. In the course of bring circumcised penis, it is merely optional in the present inven ing flaps 6 and 7 together, the top portion 9 may fold into a tion. position as shown more specifically in FIGS. 1 and 2. It 0044 FIG. 15A is an enlarged view of central portion 8 of should be noted that although the figures show the securement FIG. 8, showing the details of the protecting surfaces of the means across a Substantial portion of the flaps 6 and 7, the area bandage portion which will impact against the body part or of flaps 6 and 7 having a securement means thereon can vary plant part to which the invention dressing is being applied. in both length and width as desired so long as the securement Generally, the center portion 8 includes an outer wall 27 means, when moved to a closed position about a body part do formed by the outside surfaces of portions 20A and 20B and not adhere to circumferential areas of the central portion 8. an inner wall 26 formed by the inner portions of opposing but only to securement means areas. An alternative embodi portions of 20A and 20B. Portions 20A and 20B may begauze ment has flaps 6 and 7 extending a minimum distance from or any other suitable material. Lining portions 17 and 18 can central portion 8 and has securement means extensions there be fitted flushly against the inner wall 26 and sandwiched from So that when brought together into a closed position between opposing portions 20A and 20B. While FIG. 15 about a body part, flap portions 6 and 7 may or may not meet shows portions 20A and 20B as only in the central portion 8, alternative and preferred embodiments have portions 20A each other, but the securement means extension thereof do and 20B extending partially into or completely across the left meet each otherina way that allows for the Securement means and right flap regions 6 and 7. In many embodiments, lining to mate to each other and secure the device in place without portions 17 and 18 are merely a coating which prevents adhe attaching to the central portion 8. sion or sticking of the device to the skin, Such as petrolatum, 0042 FIGS. 11-13 show the device of FIG. 7 in which the which can be applied in the manufacturing process or can be device is in alternate pre-use folded positions rather than the added by the user at the time of use. Additionally, portion 20A flat opened position of FIGS. 6 and 7. In FIGS. 11-13, the and lining portion 17 may constitute a unitary layer if the peripheral ends of the flaps 6 and 7 (distal from the central material of portion 20A is naturally skin-non-adherent or is portion 8) have been displaced centrally, but instead of open impregnated with a materials so as to be skin non-adherent. ing the sleeveportion as in FIG. 8, the central portion 8 has not Xeroform R) (petrolatum impregnated gauze with 3% bismuth been opened, resulting in an upper minor flap 14 and a lower tribromophenate) is one Such suitable material (although the minor flap 15. FIGS. 12 and 13 show the device of FIG. 11 bismuth tribromophenate should preferably not be used with where the minor flaps have been displaced to opposite sides infants). Similarly, portion 20B and lining portion 18 may (FIG. 12) or to the same side (FIG. 13). For FIGS. 12 and 13, also constitute a unitary layer in the same fashion. The inner left and right may be interchanged without departing from the surface of central portion 8 (i.e., the lining portions 17 and 18 present invention. When positions such as those in FIGS. 12 if present, or the portions 20A and 20B if lining portions 17 and 13 are utilized, one must be sure that the securement and 18 are not separately present), may additionally be means chosen is one which would not result in attachment impregnated with Suitable active agents or formulations between either of the flaps 6 and 7 on the one hand and flaps thereof for any of a variety of uses. Lining portions 17 and 18 14 and 15 on the other. Other alternate pre-use folded posi or portions thereof, alone or together with corresponding tions will be apparent to those of ordinary skill in the art segments of portions 20A and 20B may be transdermal for without departing from the present invention. As an alterna mulations or transdermal devices that have been adhered to tive, a securement means cover (not shown) which is not wall 27 (iflining portions 17 and 18 and portion 20A and 20B adherent to the other portions of the device in which it comes are otherwise not separately present in the respective area) or in contact may be used to prevent adherence of the secure adhered to wall 26 (iflining portions 17 and 18 are not present ment means to other layers during manufacture, packaging, but portions 20A and 20B are present in the corresponding and storing of the device until Such time as one is ready to area). One variant of this is shown in FIG. 15B, where two apply the device. Suitable materials include any material different transdermal regions are present using two different which is easily removed when desired from the securement types of transdermal delivery. Use of transdermal delivery means and yet prevents adherence between the securement with the present invention can utilize a single transdermal means and the rest of the device when in place. For example, delivery overall or a portion of the skin-contacting Surface or when the securement means is Velcro, the securement means as shown in FIG. 15 utilize different transdermal delivery cover may be a piece of mated Velcro or a non-Velcro sleeve portions that are the same or different from one another in the slipped over the securement means. Alternatively, where the same device. In FIG. 15B, one portion of surface 27 carries a securement means is an adhesive, the securement means is a monolithic drug delivery portion 19 having one or more releasable liner that can be easily removed from such adhe active agents dispersed in a non-skin-contacting adhesive sive. Where the securement means is a Snap, no securement polymeric material, which may be cast directly on surface 27 means cover is needed. It should be noted that securement (or onto surface 26 if portion 20A is present) or precast and means covers are not required and merely optional, but may, fastened onto surface 27 (or onto surface 26) using a suitable in fact, be preferred. adhesive. A second drug delivery portion 22 of the “reservoir 0043 FIGS. 14 A and B show an embodiment of the pouch type' which generally comprises a drug-non-perme present invention as applied and secured to a wounded penis able (usually occlusive) backing 24, a drug permeable over

US 2009/0005722 A1 Jan. 1, 2009

cin, Vancomycin, Zorbamycin or mixtures thereof; pref 0.058 A more complete list of compounds, most of which erably bacitracin, neomycin, polymixin or mixtures are pharmaceutical or veterinary, which can be utilized in the thereof); present invention includes, but is not limited to: abacavir, 0050 (iii) antifungals such as, without limitation, abamectin, abanoquil, abaperidone, abarelix, abecarnil, abi acrisorcin, ambruticin, amphotericin B, azaconazole, raterone, abitesartan, ablukast, abunidazole, acadesine, aZaserine, basifungin, bifonazole, butenafine, butocona acamprosate, acaprazine, acebrochol, acebutolol, acecainide, Zole, candicidin, carbol-fuchsin, chlordantoin, ciclo acecarbromal, aceclidine, aceclofenac, acedapsone, acedia piroX, cillofungin, cisconazole, clotrimazole, denofun Sulfone, acedoben, acefluranol, acefurtiamine, acefylline gin, dipyrithione, doconazole, econozole, enilconazole, clofibrol, acefylline piperazine, aceglatone, aceglutaminde, ethonam, fenticonazole, filipin, fluconazole, flucy acemetacin, aceneuramicacid, acenocoumarol, acepeprone, tosine, fungimycin, griseofulvin, hamycin, isoconazole, acepromazine, aceprometazine, acequinoline, acesulfame, itraconazole, kalafungin, ketoconazole, lomofungin, acetaminosalol, acetanilide, acetarSone, acetaminophen, ly dimycin, mepartricin, metacresol, miconazoile, nafti acetazolamide, acetiamine, acetiromate, acetohexamide, fine, nifuratel, nifuramerone, nitralamine, nystatin, acetophenaZone, acetophenetidin, acetorphine, acetosulfone, octanoic acid, omoconazole, orconazole, oxiconazole, acetriozoic acid, acetylcysteine, acetyldigitoxin, acetyleu oxifungin, parconazole, pyrrolnitrin, rutamycin, sangui cine, acetyltributyl citrate, acetyltriethyl citrate, acevaltrate, narium, Saperconazole, scopafungin, sinefungin, Sul acexamin acid, acifran, acipimox, acitaZanolast, acitemate, conazole, terbinafine, terconazole, thiram, ticlatone, tio acitretin, acivicin, alcantate, aclarubicin, aclatonium napa conazole, tolciclate, tolindate, tolnaftate, triacetin, disilate, acolbifene, aconiazide, aconitine, acotiamide, acox triafungin, undecenylate, Zinoconazole, and mixtures atrine, acreoZast, acridorex, acriflavine, acrihellin, acrisorcin, thereof); acrivastine, acroinonide, acronine, actaplanin, actarit, 0051 (iv) and mixtures thereof, broad spectrum anti ActiqR, actinoquinol, actisolide, actodigin, acyclovir, infectives being preferable over others; adafenoxate, adalimab, adamexine, adapalene, adaprolol. 0052 (b) Local anesthetics (which may also be incorpo adatanserin, adefovir, adekalant, adelmidrol, ademitrionine, rated as desired to ease pain which main be present) include, adenosine, adibendal, adicillin, adimolol, adinazolam, without limitation, benoximate, benzocaine, bupivocaine, adiphenine, aditeren, aditoprim, adosopine, adoZelesin, butamben, chloroprocaine, cocaine, diamocaine, dibucaine, adrafinil, adrenalone, adrogolide, afalanine, afeletecan, aflo dyclonine, ethyl chloride, etidocaine, euprocin, isobutamben, qualone, afovirsen, afurolol, aganodine, aglepristone, ago lidocaine, mepevicaine, oxethazine, pramoxine, prilocaine, melatine, aklomide, alacepril, alafosfalin, alagebrium, ala pyrocaine, risocaine, rodocaine, tetracaine, and mixtures mecin, alamifovir, alanine, alanosine, alaproclate, thereof; preferably benzocaine, lidocaine, tetracaine, and alatrofloxacin, alazanine triclofenate, albaconazole, albenda mixtures thereof); Zole, albuterol, albutoin, alclofenac, alclometaSone, alcloxa, 0053 (c) Clotting agents and clotting aids (when bandag alcuronium, aldioxa, aldosterone, alemcinal, alendronic acid, ing wounds and clotting is desired), which may include, with alentemol, alepride, alestramustine, aletamine, alexidine, out limitation, alexitol, alexomycin, alfacalcidol, alfadex, alfidalone, 0054 (i) physical agents that create barriers to blood alfaprostol, alfatradiol, aldaxalone, alfentranil, alfuZosin, flow such as petrolatum, gelatin film, KY Jelly: algeldrate, algestone, alibendol, aliconazole, allifedrine, ali furane, alilusem, alimadol, alinastine, alinidine, alipaminde, 0055 (ii) thickening agents which upon dissolution in aliskiren, alitame, alitretinoin, alizapride, alletorphine, allo serum, increase its viscosity So as to slow blood flow barbitol, allocamide, allocupreide, allomethadione, allopu from the wound; rinol, allylestrenol, allylprodine, almecillin, almestrone, 0056 (iii) agents which activate, supplement, or replace alminoprofen, almitrine, almokalant, almotriptan, a component of the normally fully developed innate almoxatone, almurtide, alnespirone, alniditan, alonacic acid, clotting cascade mechanism; and mixtures thereof; alonimid, aloracetam, alosetron, alovudine, aloxidone, alox 0057 and include, without limitation, antihemophilic iprin, aloxistatin, aloZafone, alpertine, alphameprodine, factor, poliglusam, oxidized cellulose, thrombin, ami alphamethadol, alphamethyldopa, alphaprodine, alpidem, nocaproic acid, ethamsylate, Factor II, Factor V. Factor alpiropride, alprafenone, alprazolam, alprenolol, VIIa, Factor VIII (recombinant forms available as Bio alprenoXime, alprostadil, alrestatin, altanserin, altapizone, clate, Helixate FS, Kogenate FS, Recombinate and alteconazole, althiazide, altinicline, altoqualiine, altrenogast, ReFacto), Factor IX (recombinant form available as altretamine, alvemeline, alverine, alvimopan, alvocidib, ama BeneFix), Factor X, Factor XI, Factor XIa, Factor XII, dinone, amafalone, amanozine, amantadine, amantocillin, Factor XIIa, Factor XIII, Factor XIIIa, prothrombin, ambamustine, ambasilide, ambazone, ambenonium, Vitamin K, gelatin film, OXSamarin, Sulmarin, tranex ambenoxan, ambomycin, ambrisentan, ambroXol, ambruti amic acid, arachidonic acid, thromboxane A, inositol cin, ambucaine, ambucetamide, ambuphylline, ambuside, triphosphate, fibrinogen, high molecular weight kinino ambutonium, amcinafal, amcinafide, amcinonide, amdinocil gen, prekallihrein, RECOMTHROM THROMBIN, lin, amdoxovir, ambucort, amedalin, amelometasone, amelt TOPICAL(RECOMBINANT), tissue factor, calcium, olide, amelubant, ameSergide, ametantrone, amethapred. topical and local vasoconstrictors (such as, without limi amethocaine, ameZapine, amezinium, amfenac, amfepen tation epinephrine), and nucleic acids (natural deoxy torex, amfetaminil, amflutizole, amfonelic, amicarbalide, ribonucleic acid, ribonucleic acid, synthetic variants amicloral, amicycline, anidantel, amidapsone, amidephrine, thereof, and analogs thereof, oligomers and polymers amiflamine, amifloverine, amifloxacin, amifostine, amiglu thereof, and modified versions thereof, etc) as disclosed mide, amikacin, amikhelline, amiloride, amiloxate, amina in US 2007/0172432 (incorporated herein in its entirety crine, amindocate, amineptine, aminoglutethimide, amino by reference) and mixtures thereof. hippuric acid, aminolevulinic acid, aminometradine, US 2009/0005722 A1 Jan. 1, 2009 aminopentamide, aminophenaZone, aminophylline, amino naprine, becanthone, becatecarin, becliparcil, beclamide, promazine, aminopterin, aminopyrine, aminoquinol, amino beclapermin, becliconazole, beclobrate, beclomethasone, quinuride, a minorex, aminosalicylic acid, aminothiazole, beclotiamine, befetupitant, befiperide, befloxatone, amiodarone, amiperone, amphenazole, amipizone, amipro befunolol, befuraline, bekanamycin, belaperidone, belariz lose, amidulinsin, amisometradine, amisulprode, amiterol, ine, belfosdil, belotecan, beloxamide, beloxepin, bemar amithioZone, amitivir, amitraz, amitriptyline, amitriptyinox inone, bemegride, bemesetron, bemetizide, beminafil, bemi ide, amiXetrine, amlexanox, amlintide, amlodipine, parin, bemetradine, bemoradan, bemotrizinol, benactyzine, amocarzine, amodiaquine, amolanone, amonafide, amo benafentrine, benapry Zine, benaxibine, benazepril, ben proxan, amopyroquine, amorolfine, amoscanate, amosulatol, cianol, bencisteine, benclonidine, bencyclane, bendacalol, amotoSalen, amotriphene, amoxapine, amoxecaine, amox bendamustine, bendazac, bendazol, benderizine, bendroflu icillin, amoxydramine, amperozide, anphechloral, ampheni methazide, benethamine penicillin, benexate, benfluorex, done, amphetamine, amphomycin, amphotalide, amphoteri benfosformin, benfotiamine, benflurodil, benhepazone, beni cin, amplicillin, ampiroxicam, amprenavir, amprolium, dipine, benmoxin, benolizime, benorilate, benorterone, ampyrimine, ampyZine, amguinate, amrubicin, amsacrine. benoxifos, benoxaprofen, benoximate, benpenolisin, benperi amtolimetin, amustaline, amylobarbital, angestone, dol, benproperine, benrixate, bensalan, benserazide, bensul anagrelide, anakinra, anaritide, anastroZole, anatibant, anax dazic acid, bentazepam, bentemazole, bentiamine, bentipi irone, anazocine, anazolene, ancarolol, ancitabine, andolast, mine, bentiromide, bentoquatam, benurestat, benzalkonium, androstenediol, androstenedione, andulafungin, anecortave, benzarone, benzbromarone, benzestrol, benzethidine, benze anetholtrithion, angiotensin amide, andidoxamine, anidu thonium, benzetimide, benzilonium, benZindopyrine, ben lafungin, anilamate, anileridine, anilopam, anipamil, anirac Ziodarone, benzmalecene, benznidazole, benzobarbital, ben etam, anirolate, anisacril, anisindione, anisopirol, anisotro Zocaine, benzoclidine, benzoctamine, benzodepa, pine, anisperimus, anitraZafen, anpirtoline, ansoxetine, benzododecinium, benzonatate, benzopyrronium, benzo antafenite, antazoline, antazonite, anthelmycin, anthralin, quinonium, benzotript, benzoxiquine, benzoxonium, ben anthramycin, antipyrine, antrafenine, apadoline, apafant, Zoylpas, benzphetamine, benzpiperylon, benzpyrinium, ben apalcillin, apaxafylline, apaziquone, apaZone, apicycline, Zquercin, benzquinamide, benzthiazide, benztropine, aplindore, apomorphine, apovincamine, apraclonidine, apra benzydamine, benzylhydrochlorothiazide, benzylpenicillin, mycin, aprepitant, aprakalim, aprindine, aprinocarsine, benzylsulfamide, bepafant, beperidium, bephenium, bepias apofene, aprosulate, aptaZapine, aptiganel, aptocaine, arani tine, bepridil, beractant, beraprost, berberine, berefrine, ber dipine, aranotin, arbaprosil, arbekacin, arbutamine, arclofe genin, berlafenone, bermoprofen, bertosamil, berupipam, nin, ardacin, ardeparin, arecoline, arfalasin, arfendazam, bervastatin, berythromycin, besigomsin, besipirdine, beson arformoterol, argatroban, argimesna, argipressin, argipresto prodil, besulpamide, besunide, beta carotene, betacetylmeth cin, arlidone, arimoclomol, aripiprazole, armodafinil, adol, betahistine, betaine, betameprodine, betamethadol, amolol, arofylline, artinolol, arprinocid, arpromidine, arsa betamethasone, betamicin, betamipron, betaprodine, betax nilic acid, arteflene, artemether, artemisinin, artemotil, arteni olol, betazole, bethanacol, bethanidine, betiatide, betox mol, artesunate, articaine, artilide, arundic acid, arZoxifene, ycaine, bevacizumab, bevantolol, bevonium, beXarotene, ascorbic acid, arsenapine, aseripide, asimadoline, asobamast, bexlosteride, bezafibrate, beztiramide, bialamicol, biapenem, asocainol, asoprisnil, aspartame, aspartocin, asperlin, aspirin, bibeZonium, bibrocathol, bicalutamide, bici fadine, bicoldil, aspoxicillin, astemizole, astromicin, asulacrine, atameStane, biclofibrate, biclotymol, bicozamycin, bidimazium, bidiso ataprost, ataquimast, atazanavir, atenolol, atevirdine, ati mide, bietamiverine, bietaserpine, bifemelane, bifepramide, beprone, atilmotin, atipamezole, atipromod, atiprosin, atizo bifeprofen, bifeprunox, bifluranol, bifonazole, bilastine, ram, atliprofen, atocalcitol, atolide, atomoxetine, atorvasta bimakalim, bimatoprost, bimoclomol, bimosiamose, bin tin, atosiban, atovaquone, atracurium, atrasentan, atraleuton, darit, binedaline, binfloxacin, binfibrate, biniramycin, bini atrimustine, atrinositol, atromepane, atropine, atropine oxide, Zolast, binodenosine, binospirone, bioallethrin, botin, bipen auranofin, aurothioglucose, avanafil, avasimibe, avicatonin, amol, biperiden, biphenamine, biricodar, biriperone, avalamycin, aviptadil, avitriptan, avizafone, avobenzone, bisacodyl, bisantrene, bisaramil, bisbendazole, bisben aZoparcin, avorelin, avridine, axamozide, axitirome, axoma tiamine, bisbutiamine, bisdequilinium, bisfenaZone, bisfenti dol, azabon, azabuperone, azacitidine, azacitidine, azaclo dine, bisnafide, bisorbin, bisoctriazole, bisoprolol, bisorcic, rzine, azaconazole, azacoSrterol, azacyclonol, azaftozine, bisoxatin, bispyrithione, bithonol, bithionoloxide, butipa azalanstat, azalomycin, azaloxan, azamethiphos, azametho Zone, bitolterol, bitoscanate, bivalirudin, bizelesin, bleomy nium, azamulin, azanator, azanidazole, azaperohe, azapetine, cin, blonanserine, bluenSomycin, bofumustine, bolandiol. aZaquinzole, azaribine, azarole, aZaserine, aZasetron, aza bolasterone, bolazine, boldenone, bolenol, bolmantalate, spirium, azastene, azatadine, azathioprine, azelaic acid, bometolol, bopindolol, bomaprine, bornaprolol, borelone, aZelastine, aZelinnidipine, azepexole, azepindole, azetepa, borocaptaine, bortezomib.bosentan, botiacrine, botulintoxin, aZetirelin, azidamfenicol, azidocillin, azimexon, azimilide, boxidine, brallobarbital, brasofensine, brazergoline, bre aZintamide, azipramide, azithromycin, azlocillin, azlocillin, fonalol, bremazocine, brequinar, bretazenil, bretyllium, aZolimine, azosemide, aztomycin, aztreonam, aZumolene, brifentanil, brimonidine, brinazaprone, brindoxime, brin bacampicillin, bacitracin, baclofen, bacmecillinam, bakepro Zolamide, brivudine, brobactam, broclepride, brocrestine, fen, balaglitaZone, balaZipone, balofloxacin, balsalazide, brocrinat, brodimoprim, brofaromine, brofoxine, brolacona bamaluzole, bamaquimast, bambermycin, bambuterol, bam Zole, brolamfetamine, bromadoline, bromamid, bro ethan, bamifylline, bamipine, bamirastine, bamnidazole, mazepam, bromchlorenone, bromebric acid, bromerguride, banoxantrone, baduiloprim, barbexaclone, barbital, barixi brometenamine, bromfenac, brom hexene, bomindione, bro bat, barmastine, barnidipine, barucainide, barusiban, basifun misovalum, bromociclen, bromocriptine, bromodiphenylhy gin, batalbulin, batanopride, batebulast, batelapine, batilol. dramine, bromofenfos, bromofos, bromopride, bromox batimastat, batoprozine, baxitoizine, baZedoxifene, bazi anide, bromperidol, brompheniramine, broparestrol,

US 2009/0005722 A1 Jan. 1, 2009

dinoprost, dinoprostone, dinsed, diohippuric acid, dioSmin, enoxacin, enoxamast, enoxaparin, enoXimone, enoXolone, diotyrosine, dioxadrol, dioxamate, dioxaphetyl butyrate, enipiprazole, enoxaprin, enpiroline, enprazepine, enprofyl dioxation, dioxethedrin, dioxifedrine, dioxybenazone, dioxy line, enpromate, enprostil, enramycin, enrasentan, enrofloxa line, dipenine, diperodon, diphemanil, diphenadione, cin, ensacillin, ensulizole, entacapone, entecavir, entSufon, diphenan, diphenchloxazine, diphenhydramine, diphenidol. enviomycin, enviradene, enviroxime, enZacamene, anZastau diphenoxylate, diphenylpiperidinomethyldioxolan, diphe rin, epalrestat, epanolol, eperezolid, eperisone, eperVudine, nylpyraline, diphenoxazide, dipipanone, dipiproverine, ephedrine, epicainide, epicillin, epicriptine, epiestriol, dipivefrin, diprafenone, diprenorphine, diprobutine, dipro epimestrol, epinastine, epinephrine, epinepheryl, epipropi fene, diprogulic acid, diproleandomycin, diprofylline, dipro dine, epirizole, apiroprim, epirubicin, epitetracycline, epithi qualone, diproteverine, diprotrizoate, diproxadol, dipy azide, epitiostanol, eplerenone, elivanserin, epoprostenol, ridamole, dipyrithione, dipyrocetyl, dipyrone, diduafosol, epostane, eprazinone, eprinomectin, epristeride, eprobemide, dirithomycin, dirlotapide, disermolide, disquonium, disob eprosartan, eprovafen, eproXindine, eprozinol, epsipranel, utamide, Sidofenin, Sdisogluside, disopyramide, disoxaril. epaloprost, eptapirone, eptaplatin, eptastigmine, eptazocin, distigmine, disufenton, disulergine, disulfamide, disulfiram, eptifibatide, equillin, erbuloZole, erdosteine, ergocalciferol, disupraZoole, ditazole, ditekiren, ditercalinium, dithiaanine, ergonovine, ergotamine, eritoran, erizepine, erlotinib, ercain ditiocade, ditiocarb, ditiomustane, ditolamide, ditophal, div ide, ersentilide, ertapenem, ertiprotafib, erythrity1 tetrani abuterol, divalproex, divaplon, dixanthogen, dizatrifone, trate, erythromycin, erythropoietin, esafloxacin, esaprazole, dizcilpine, dobesilate, dobupride, dobutamide, dobutamine, esatenolol, escitalopram, esculamine, eseridine, esflurbipro docarpamine, docebenone, docetaxel, doconazole, doconex fen, esketamine, escarbazepine, esmolol, esomeprazole, eso ent, docosanol, docusate, dodeclonium, dodicin, dofamium, narimod, esorubicin, esoxybutynin, espatropate, esproquin, dofecquidar, dolfetilide, dolasetron, doliracetam, domazoline, estazolam, estradiol, estramustine, estraZinol, estriol, estro domiodol, domiphen, domipizone, domitroban, domopred furate, estrogens, estrone, estropipatenesupone, esZopiclone, nate, domoxin, domperidone, donepezil, donetidine, doni etabenzarone, etacepride, etafedrine, etafenone, etalocib, triptan, dopamantine, dopamine, dopexamine, dopropidil, etamestrol, etaminile, etamiphylline, etamocycline, etaner doqualast, dorampimod, doramectin, doranidazole, doras cept, etanidazole, etanterol, etaqualone, etarotene, etasuline, tine, Soreptide, doretinel, doripenem, dorZolamide. dosergo etazepine, etazolate, etebenecid, eterobarb, etersalate, side, doSmalfate, dotarizine, dotefonium, dothiepin, doxacu ethacridine, ethacrynic acid, ehtambutol, ethamivan, etham rium, doxapram, doxaprost, doxazosin, doxefazepam, Sylate, ethaverine, ethenZameide, ethiazide, ethinamate, ethi doxenitoin, doxepine, doxergocalciferol, doxibetasol, doxi nyl estradiol, ethionamide, ethisterone, ethoheptazine, etho fluridine, doxofylline, doxorubicin, doxpicomine, doxycy moxane, ethonam, ethopabate, ethopropazine, ethoSuximide, cline, doxylamine, draflazine, dramedilol, draquinolo, drazi ethotoin, ethoxazene, ethoxazorutoside, ethoXZolamide, dox, dribendazolew, drimidene, drobuline, drocinonide, ethybenztropine, ethyl biscoumacetate, ethyl carfluZepate, droclidinium, drofenine, droloxifene, drometrizole, dromo ethyl cartrizoate, ethyl dibunate, ethyl dirazepate, ethyl stanolone, dronabinol, drinedarone, dropempine, droperidol. loflazepate, ethylestrenol, ethylhydrocupreine, ethylmeth droprenilamine, dropropizine, drospirenone, drotaverine, ylthiambutene, ethylmorphine, ethylnorepinepherine, ethyl drotebanol, droxacin, droXicainide, droxicam, droxidopa, stilbamine, ethylnerone, ethylnodil, ethypicone, etibenda droximavir, droxypropine, duaZomycin, dulofibrate, dulloxet Zole, eticlopride, eticyclidine, etidocaine, etidronate, ine, duloZafone, dumorelin, dumetacin, duoperone, duprac etidronic acid, etifelmine, etifenin, etifoxine, etilamfetamine, etam, dutasteride, dyclonine, dyhydrogestrone, dymanthine, etillefrine, etilevodopa, etinidine, etipirium, etiprendol, dyphylline, ebalZotan, ebastine, eberconazole, ebiratide, etiproston, etiracetam, etiroXate, etisazole, etisomicin, etisul ebrotidine, ebselen, ecabapide, ecabet, ecadotril, ecalcidene, ergine, etizolam, etocarlide, etocrylene, etodolac, etodroX ecamsule, ecastolol, ecenofloxacin, echothiophate, eciprami izine, etofamide, etofenamate, etofenproX, etofibrate, etofer dil, eclanamine, eclaZolast, ecomustine, econazole, ecopi min, etofuradine, etofylline, etoglucid, eorolex, etolotifen, pam, ecraprost, ectylurea, edaglitaZone, edaravone, edatrex etoloxamine, etomidate, etomidoline, etomoxir, etomitaZene, ate, edelfosine, edetol, edifolone, edogestrone, edonentan, etonogestrel, etoperidone, etoposide, etoprindole, etoprine, edotecarin, edotreotide, edoxudine, edratide, edronocaine, etoricoxib, etorphine, etosalamide, etoxadrol, etoxeridine, edrophonium, efaproxiral, efaroxan, efavirenz, efegatran, etoZolin, etrabamine, etravirine, etretinate, etriciguat, efepristin, efetozole, efletirizine, eflomithine, efloxate, eflu etryptamine, etymemazine, eucaine, eucalyptol, eugenol, cimibe, elfiumast, efonidipine, efrotomycin, eganoprost, euprocin, evandamine, evenirnmicin, everolimus, evicromil. eglumetad, egtazic acid, equalen, elacridar, elantrine, elan exalamide, exanetazime, examorelin, exaprolol, exatecan, Zepine, elaarofiban, elbanizine, eldacimibe, eletriptan, elf exemestane, exenatide, exepanol, exifone, exiprofen, azepam, elgotipine, elinafide, eliprodil, elisartan, ellagic acid, exisulind, ezetimibe, ezlopitant, factor VII (such as elliptinium, elmustine, elnadipine, elopiprazole, elsamitru NovoSeven(R), fadolmidine, fadrozole, falecalcitriol, falin cin, eltanolone, eltenac, eltoprazine, elucaine, elvucitabine, tolol, fallpamil, falnidamol, famciclovir, famirapinium, elzasonan, elziverine, emakalim, emapunil, embramine, famotidine, famotine, fampiridine, famprofaZone, fampronil. embusartan, embutramide, emedastine, emepronium, emet fananserin, fanapanel, fandofloxacin, fandoSentan, faneti ine, emeglitate, emilium, emiteflur, emiverine, emodepside, Zole, fantofarone, fantridone, farglitazar, fasidotril, fasiplon, emopamil, emorfaZone, emitricitabine, emylcamate, enado fasoracetam, faudil, fazadinium, faZarabine, febantel, febar line, enalapril, enalaprilat, enalkiren, enaZadrem, enbucrilate, bamate, febuprol, febuverine, febuxostat, feclemine, feclobu encainide, enciprazine, enclomiphene, encyprate, endix Zone, fedotozine, fedrilate, felbamate, felbinac, felipyrine, aprine, endomide, endralazine, endrysone, enecadin, enefex felodipine, feloprentan, fely pressin, femoxetine, fenabutene, ine, enestebol, enfenamic acid, enfluvirtide, englitaZone, eni fenacetinol, fenaclon, fenadiazole, fenaftic acid, femalamide, clobrate, enilconazole, eniloSpirone, eniluracil, eniporide, femalcomine, fenamifuril, fenamole, fenaperone, fenbenda enisoprost, enloplatin, enocitabine, enofelast, enolicam, Zole, fenbenicillin, fenbufen, fenbutreazate, fencamfamin, US 2009/0005722 A1 Jan. 1, 2009

fencibutirol, fenclexonium, fleclofenac, fenclonine, fenclo line, furalazine, furaltadone, furaprofen, furazabol, furazoli rac, fenclozic acid, fendiline, fendizoate, fendosal, feneritrol, done, furazolium, furbicillin, furcloprofen, furegrelate, fure fenestrel, fenethazine, fenethylline, fenetradil, fenflumizole, thidine, furfenorex, furidarone, furmethoxadone, furnidipine, fenfluramine, flenfluthrin, fengabine, fenharmane, fenimide, furobufen, furodazole, furofenac, furomazine, furomine, feniodium, fenipentol, fenirfibrate, fenisorex, fenitrothion, furosemide, furostilbestrol, fursalan, fursultiamine, fur fenleuton, fenmetoZole, fenmetraminde, fenobam, fenocinol, therene, furtrethonium, fusafungine, fusidate, fusidic acid, fenocitimine, fenofibrate, fenoldopam, fenoprofen, fenot fuZlocillin, gabapentin, gabapexate, gaboxadol, gacyclidine, erol, fenoerine, fenoxazoline, fenoxedil, fenozolone, fenpen gadobenate, gadobutrol, gadocolectic acid, gadodiamine, tadiol, femperate, fenprpalone, fenpipramide, fenpiprane, fen gadofoSVeset, gadomelitol, gadopenamide, gadopentetate, piverinium, fenprinast, fenproporex, fenprostalene, gadoteric acid, gadoteridol, gadoversetamide, gadoxetate, fenduiaone, fenretinide, fenspiride, fentanyl, fenthion, fen gadoxeticaicid, galamustine, galntamine, galarubicin, gala tiazac, fenticlor, fenticonazolem, fentonium, fenvalerate, Somite, galdansetron, gallamine triethiodide, gallopamil, fenyripol, fepentolic acid, fepitrizol, fepradinol, feprazone, galocitabine, galosemide, galtifenin, gamfexine, gamolenic fepromide, feprosidinine, ferpifosate, fesoterodine, fetoxy acid, gamaXolone, ganciclovir, ganefromycin, ganglefene, late, fexicaine, fexinidazole, fexofenadine, fezatione, fezola gainstigmine, gantacurium, gantofiban, gapicomine, gapro mine, fiacitabine, faluridine, fibracillin, fidarestat, fidexaban, midine, garenoxacin, gatifloxacin, gavestinel, geclosporin, fiduXosin, figopitant, filaminast, filenadol, filipin, filgrastim, gedocarnil, gefarnate, gefitinib, gemazocine, gemcabene, finafloxacin, finasteride, fingolimod, fipamezole, fipexide, gemcadiol, gemcitabine, gemeprost, genfibtrozil, gemifloxa fipronil, firocoxib, flavamine, flavodic acid, flavodilol, fla cin, gemopatrilat, gentamicin, gepefrine, gepirone, gero voxate, flazalone, flecainide, flerobuterol, fleroxacin, flesi quinol, gestaclone, gestadienol, gestodene, gestonorone, noxan, flestolol, fletazepam, flezelastine, flibanserin, gestrinone, geVotroline, gimatecan, gimeracil, giparmen, flindokalner, flocalcitriol, floctafenine, flomoxef, floptopi giracodazole, giractide, girisopam, gitaloxin, gitoformate, one, florantyrone, flordipine, floredil, florfenicol, florifenine, glafenine, glaspimod, glatiramer acetate. glemanserin, glen flosatidil, flosequinan, flosulide, flotrenizine, floverine, flox vastatin, gliamilide, glibotnuride, glibutimine, glicaramide, acillin, floxacrine, floxuridine, flucizine, fluialamine, flu glicetanide, gliclazide, glicondamine, glidaZamide, gliflu anisone, fluazacort, fluaZuron, flubanilate, flubendazole, mide, glimepiride, glipalamide, glipizide, gliquidone, flubepride, flucarbril, flucetorex, flucindole, flucinprazine, glisamuride, glisentide, glisindamine, glisolamide, glisox flucloronide, fluconazole, flucrylate, flucytosine, fludalanine, epide, gloxazone, gloXimonam, glucametacin, glucosamine, fludarabine, fludazonium, fludeoxyglucose, fludiazepam, flu gluronolactone, glucuronamide, glunicate, glyburide, gly dorex, fluidoxopone, fludrocortisone, flufenamic acid, buthiazole, glubuzole, glycopyrrolate, glycylamide, glyhexa flufenisal, flufosal, flufylline, fugestone, fluindarol, fluindi mide, glymidine, glyoctamide, glyparamide, glypinamide, one, flumazenil, flimecinol, flumedroxone, flumequine, flu glyprothiazole, gly Sobuzole, goralatide, goserelin, gramici meridone, flumethasone, flumethiazole, flumetramide, din, granisetron, grepafloxacin, griseofulvin, guabenXan, flumexadol, flumeZapine, fluminorex, flumizole, lfumox guacetisal, guafecainol, guaiactamine, guaiapate, guaietolin, onide, flunamine, flunarizine, flunidazole, flunisolide, fluni guaifenesin, guaimeSal, guaisteine, guaithylline, guanabenz, trazepam, flunixin, flunoprost, flunoxaprofen, fluocinolone, guanacline, guanadrel, guanaZodine, guanclofine, guancy fluocinonide, fluocortin butyl, fluocortolone, fluorescein, dine, guanethidine, guanfacine, guanisoquin, guanoclor, gua fluoresone, fluorodopa, fluorometholone, fluorosalan, fluo noctine, guanoXabenz, guanoxan, guanoxyfen, gusperimus, rouracil, fluotracen, fluoxetine, fluoxymesterone, fluparoxan, halazepam, halaZone, halcinonide, halethazole, halobetasol, flupentiXol, fluperamide, fluperlapine, fluperolone, fluphea halocortolone, halofantrine, halofenate, halofuginone, Zine, flupimazine, flupirtine, flupranone, fluprazine, flupred halometaSone, halonamine, halopemide, halopenium, halo nidene, fluprednisolone, fluprofen, fluprofylline, fluprodua peridol, halopredone, haloprogesterone, haloprogin, halox Zone, fluprostenol, fluguaZone, fluradoline, flurandrenolide, aZolam, haloxon, haloqionol, hamycin, hedaquinium, helio flurantel, flurazepam, flurbiprofen, fluretofen, flurithromy mycin, hepronicate, heptabarbital, heptaverine, heptolamide, cin, flurocitabine, flurofamide, flurogestone, flusoxolol, flus hepzidine, heroin, hetacillin, hetaflur, heteronium, hexachlo piperone, fluspirilene, fluticasone, flutamide, flutazolam, rophene, hexacyclonate, hexacy prone, hexadiline, hexafluo flutemazepam, flutiazin, fluticaSone, flutizenol, flutomidate, renium, hexamethonium, hexaminolevulinate, hexapradol, flutonidine, flutoprazepam, flutrimazole, flutroline, hexaprofen, hexapropymate, hexasonium, hexazole, hexe flutropium, fluvastatin, fluvoxamine, fluzinamide, fluZo dine, hexestrol, hexetidine, hexobarbital, hexobendine, hexo perine, fodipir, folic acid, follitropin alpha, follitropin beta, cyclium, hexoprenaline, hexopyrronium, heylcaine, hista fomepizole, fomidacillin, fominoben, fomiversen, mine, histapyrrodine, histidine, homarylamine, homatropine, fomocaine, fonazine, fondaparinux, fopiirtoline, forasartan, homidium, homochlorcyclizine, homofenazine, forfenimex, formebolone, formestane, formetorex, formini homopipramol, homosalate, homprenorphine, hopantenic trazole, formocortal, formoterol, forodesine, foropafant, fos acid, hoquizil, human growth hormone, Humalin R, Huma amprenavir, fosarilate, fosazepam, foSenazide, fosflucona log R, human papilloma quadrivalent types 6,11,16,18. Zole, foSfocreatinine, fosfomycin, foSfonet, fosfosal, hycanthone, hydracarbazine, hydralazine, hydragaphen, fosfructose, fosinopril, fosinoprilat, foSmenic acid, fosmido hydrobentizide, hydrochlorothiazide, hydrocodone, hydro mycin, fosopamine, fosphenytoin, fospirate, fosquidone, cortisone, hydroflumethiazide, hydromadinone, hydromor fostedil, foSrtriecin, fosveset, fotemustine, fortrenamine, phinol, hydromorphone, hydroquinone, hydroxyindasate, fozivudine, frabuprofen, fradafiban, frakefamide, framycetin, hydroxyindasol, hydroxocobalamin, hydroxyamphetamine, frentizole, freselestat, fronepidil, fropenem, froVatriptan, hydroxychloroquin, hydroxydione, hydroxypethidine, froxiprost, ftaxilide, ftivazide, formetazine, forpropazine, hydroxyphenamate, hydroxyprocaine, hydroxyprogesterone, fubrogonium, fudosteine, fuladectin, fulvestrant, fumagillin, hydroxypyridine tartrate, hydroxystenozole, hydroxyStilba fumoxicillin, fungimycin, fuprazole, furacrinic acid, furafyl midine, hydroxytetracaine, hydroxyzine, hymecromone, US 2009/0005722 A1 Jan. 1, 2009 11 hyoscyamine, ibafloxacin, ibandronate, ibazocine, ibopam iZonsteride, josamycin, kainic acid, kalafungin, kanamycin, ine, ibrolipim, ibrotamide, ibudalast, ibufenac, ibuprofen, kebuZone, keracyanin, ketamine, ketanserin, ketazocine, ibuproxam, ibutamoren, ibuterol, ibutilide, ibuverine, icari ketazolam, kethoxal, ketipramine, ketobemidone, ketocaine, din, icatibant, iclaprim, icazepam, icodulinium, icofungipen, ketocainol, ketoconazole, ketoprofen, ketorfanol, ketorolac, ifometaSone, icopezil, icosapent, icospiramide, icotidine, ketotifen, ketotrexate, khellin, khelloSide, kitasamycin, labe icrocaptide, idarubicin, idaverine, idaZOXan, idebenone, ide talol, labradimil, lachesine, lacidipine, lacosamide, lactalfate, nast, idoxifene, idoxuridine, idralfidine, idramantone, lactilol, lactulose, ladirubicin, ladostigil, laflunimus, lafuti idraparinux, idrapril, idiremcinal, idrociliamide, idronoxil, ine, laidlomycin propionate, lamifiban, lamivudine, lamot idropranolol, iferanserin, ifetroban, ifosfamide, ifoxetine, rigine, lamitidine, lanatoside, landiolol, lanepitant, lanicem iganidipine, igmesine, iguratimod, ilaprazole, ilatreotide, ine, laniquidar, lanoconazole, lanperisone, lanproston, ilepcimide, iliparcil, ilmofosine, illoomastat, illonidap, illoperi lanreotide, lanSoprazole, lantusg, lapatinib, lapisteride, done, imafen, imanixil, imatinib, imaZodan, imcarbofos, imi laprafylline, lapyrium, laquinimod, lasalocid, lasinavir, laso clopazine, imidafenacin, imidapril, imidaprilat, imidocarb, foXifene, latanoprost, laudexium, laurcetium, laurocapram, imidoline, imidurea, imiglitazar, imiglucerase, imiloxan, lauroguadine, laurolinium, lauryl isoquinolinium, lavolti iminophenimide, imipenem, imipramine, imipraminoxide, dine, lazabemide, lecimibide, ledazerol, ledoxantrone, lefe imiquimod, imirestat, imitrodast, imolamine, imoxiterol, tamine, leflunomide, lefradafiban, leiopyrrole, lemidosul, impacarzine, implitapide, impromidine, improSulfan, imu lemidipine, leminoprazole, lemoxinol, lemuteporfin, lanali racetam, inamirone, inaperisone, incadronic acid, inda domine, lenampicillin, lenapenem, leniquisin, leuperone, caterol, indacrinone, indalpine, indanazoline, indanidine, leptacline, lercanidipine, lergotrile, lerisetron, lesoptiron, les indanorex, indapamide, indatraline, indecainide, indelox taurtinib, leteprinim, leteprinim, letimide, letosteine, letra azine, indenolol, indibulin, indigotindisulfonate, indinavir, Zuril, letrozole, leucinocaine, leucocianidol, leucovorin, leu indiplon, indisetron, indobufen, indocate, indocyanine green, prolide, leurubicin, levalbuterol, levallorphan, indolapril, indolidan, indomethacin, indopanolol, indopine, levamfetamine, levamisole, levcromakalim, levcycloserine, indoprofen, indoramin, indorenate, indoxole, indriline, levdobutamine, levemoamil, levetiracetam, levisoprenaline, inecalcitol, Infanrix R, infliximab, ingliforib, inicarone, levlofexidine, levmetamfetamine, levobetaxolol, inocterone acetate, inogatran, inosine, inositol, improquoone, levobunolol, levobupiacaine, levocabastine, levocamitine, interferon beta-1a, interferon betalb, intoplicine, intrazole, levodopa, levodropropizine, levofacetoperane, levofenflu intriptyline, insulin, insulin analog, inulin, iobenguane, ramine, levofloxacin, levofluraltadone, levoleucovorin, iobenzamic acid, iobitridol, iobutoic acid, icanlidic acid, levomenol, levomepromazine, levomethadone, levomethadyl iocarmic acid, iocetamic acid, iodamine, iodipamide, iodix acetate, levomethorphan, levometiomeprazine, levo anol, iodoantipyrine, iodocholesterol, iodohippurate, moprolol, levomoramide, levonantradol, levonordefrin, iodoquinol, iodothiouracil, idoxamic acid, iofetamine, ioflu levonorgestrel, levophenacylmorphan, levopropoxyphene, pane, iofratol, ioglicic acid, ioglucol, ioglunide, ioglycamic levopropylcilline, levopropuylhexedrine, levoprotiline, acid, iogulaamide, iohexol, iolidonic acid, iolixanic acid, levorin, levormeloxifene, levorphanol, levosalbutamol, iolopride, iomazenil, iomeglamic acid, iomeprol, iomethin, levosemotiadil, levosimendan, levoSulpiride, levothyroxine, iometopane, iomorinic acid, iopamidol, iopanoic acid, iopen levotofisopam, levoxadrol, lexipafant, lexithromycin, lex tol, iophendylate, iophenoxic acid, iopromide, iopronic acid, ofenac, liarozole, libecillide, libenzapril, licarbazepine, iopydol, iopydone, iosarcol, isofenamic acid, io.seric acid, licofelone, licostinel, lidadronic acid, lidamine, lidanserin, iosimenol, iosimide, ioSulamide, ioSumetic acid, iotasul, iot lidocaine, lidoferin, lidorestat, lifariaine, lifibrate, lifibrol, eric acid, iothalamate, iothalamic acid, iotranic acid, iotri lilopristone, limaprost, limazocic acid, linarotene, lincomy side, iotrizoic acid, iotrolan, iotroxic acid, iotyrosine, iovesol, cin, lindane, linetastine, lineZolid, linogliride, linopirdine, ioxabrolic acid, ioxaglic acid, ioxilan, ioxitalamic acid, ioXo linotroban, lisinidomine, lintitript, lintopride, liothyronine, trizoic acid, ioZomic acid, ipamorelin, ipazilide, ipenox lipoic acid, liraglutide, liranaftate, lirequinil, lirexapride, lir aZone, ipexidine, ipidacrine, ipodate, iprgratine, ipramidil, imilast, liroldine, lisadimate, lisinopril, lisofylline, lisuride, ipratropium, ipravacaine, iprazochrome, ipriflavone, iprin litomeglovir, litoxetine, litracen, lividomycin, lixazinone, lix dole, ipocinidine, iproclozide, iprocrodol, iprofenin, iprohep ivaptan, lobapolatin, lobeline, lobendazole, lobenzarit, lobu tine, iproniazide, ipronidazole, iproplatin, iprotiazem, iproX cavir, lobuprofen, locicortolone, lodaxaprine, lodaZecar, amine, iprozilamine, ipsalazide, ipsapirone, iquindamine, lodelaben, lodenosine, Iodinixil, lodiperone, lodoxamide, iralukast, irampanel, irbesartan, irindalone, irinotecan, lofemizole, lofendazam, lofentanil, lofepramine, lofexidine, irloxacin, irofulven, irolapride, iroXanadine, irsogladine, loflucarban, lombazole, lomefloxacin, lomeguarib, lomeriZ irtemazole, isalidole, isalsteine, isamfaZone, isamoltan, ine, lometraline, lometrexol, lomevactone, lomifylline, lomo isamoxole, isatoribine, isaxonine, isbogrel, isbufylline, fungin, lomustine, lona famib, lonapalene, lonaprofen, lona ispamicin, isoamilinile, isobromindione, isobucaine, isob Zolac, lonidamine, loperamide, lopinavir, lopirazepam, utamben, isocarboxazid, isoconazole, isocromil, isoetharine, lopobutan, loprazolam, loracarbeflorajmine, lorapride, lora isoflupredone, isoflurophate, isomazole, isomerol, isometa tadine, lorazepam, lorbamate, lorcainide, lorcinadol, lore midium, isomethadone, isometheptene, isomolpan, isoamy clezole, lorglumide, lormetazepam, lomoxicam, lopiprazole, lamine, isoniazid, isonixin, isoprazole, isoprednidene, iso lortalamine, lorZafone, losartan, losigamone, losindole, profen, isopropamide, isopropicillin, isoproterenol, loSmiprofen, losoxantrone, losulazine, loteprednol, isoSrbide, isospaglumic acid, isosulfan blue, isosulpride, lotrafiban, lotrifen, lotucaine, lovastatin, loviride, loxanast, isothipendyl, isotiquimide, isotretinoin, isoxaprolol, isox loxapine, loxiglumide, loxoprofen, loxoribine, lozilurea, epac, isoxicam, isoXSuprine, isradipine, israpafant, istrdefyl lubazodone, lubeluzole, lubiprostone, lucanthone, lucarta line, itameline, itanoXone, itasetron, itaZigrel, itopride, itra mide, lucimycin, lufenuron, lufironil, lufuradom, lulicona conazole, itriglumide, itrocainide, itrocinonide, iturelix, Zole, lumiracoxib, lupitidine, luprostiol, lurasidone, luro ivbradine, ivarimod, ivermectin, ivoqualine, ixabepilone, setron, lurototecan, lusaperidone, luxabendazole, lydimycin, US 2009/0005722 A1 Jan. 1, 2009 lymecycline, lynestrenol, lypressin, mabuprofen, mabuterol, moxirate, methyl Salicylate, methylatropine, maduramicin, mafenide, mafoprazine, mafosfamide, methylbenactyzium, methylbenzethonium, methylcromone, malathion, maleylsulfathiazole, malotilate, mangafodipir, methyldesorphine, methyldihydromorphine, methyldopa, manidipine, manifaxine, mannomustine, manoZodil, manta methylene blie, methylephedrine, methylergometrine, meth begron, mapinastine, maprotiline, maraviroc, marbofloxacin, ylergonovine, methyllparaben, methylphenidate, methyl maribavir, maridomycin, marimastat, mariptiline, maropi prednisolone, methyltestosterone, methylthiouracil, meth tant, maroxepin, masoprocol, maxacalcitol, maytansine, ynodiol, methyprylon, methysergide, metiamide, metiapine, maZapertine, maZaticol, mazindol, maZipredone, mazokalim, metiazinic acid, metibride, meticrane, metildigoxin, metin mebanazine, mebendazole, menbenoside, mebeverine, meb dizate, metioprim, metioxate, metipirox, metiprenaline, eZonium, mebhydrolin, mebiquine, mebolazine, mebrofenin, metitepine, metizoline, metkephamid, metochalcone, meto mebutamate, mebutizide, mecamylamine, mecarbinate, cinium, metoclopramide, metocurine, metofenazate, mecetronium, meciadanil, mecinarone, meclinertant, mecliz metogest, metolaZone, metomidate, metopimazine, metopon, ine, meclocycline, meclofenamaic acid, meclofenoxate, metoprine, metoprolol, metoquizine, metoserpate, metostile meclonazepam, mecloqualone, meclorisone dibutyrate, nol, metoxepin, metrafazoline, metralindole, metrazifone, mecloxamine, mecobalamin, medazepam, medazomide, metrenperone, metribolone, metrifonate, metrifudil, metriza medetomidine, medibazine, medifoxamine, medorinone, mide, metrizoate, metronidiazole, meturedepa, metyrapone, medorubicin, medrogestrone, medronic acid, medroxalol, metyrosine, mevastatin, mexafylline, mexazolam, mex medroxyprogesterone acetate, medrylamine, medrysone, enone, mexiletine, mexiprosil, mexoprofen, mexrenoate, mefeclorazine, mefenamic acid, mefenidil, mefenidramium, meZacopride, meZepine, mezilamine, mezlocillin, mefenorex, mefeserpine, mefexamide, mefloquine, mefru miaanserin, mibefradil, mibolerone, miboplatin, micafungin, side, megalomycin, megestrol, megace, meglitinide, miconazole, micronomicin, midaflur, midafotel, midaglizole, meglucycline, meglumine, meglutol, meladrizine, melagat midamaline, midaxifylline, midazogrel, midazolam, mideca ran, melarsomine, melarsonyl, melarsoprol, meldonium, mycin, midestein, midodrine, midostaurin, mifentidine, melengestrol acetate, meletimide, melevodopa, melinamide, mifepristone, mifobate, iglitol, miglustat, mikamycin, melitracen, melizame, meloxicam, melperone, melphalan, milacainide, millacemide, milameline, milataxel, milenper melduinast, meluadrine, memantine, memotine, menabitan, one, milfasartan, millipertine, miloxacin, milrinone, miltefos menadiol, menadione, menadoxime, menatetrenone, menb ine, milverine, mimbane, minalrestat, minamestane, utone, menfegol, menglytate, menitrazepam, menoctone, minaprine, minaxolone, mindodilol, mindoperone, minepen menogaril, menobentine, mepazine, mepenZolate, meperi tate, minocromil, minocycline, minodronic acid, minopafant, dine, mephenesin, mephenoxalone, mephentermine, minoxidil, mioflaazine, mipitroban, mipragoside, miproX mephenytoin, mephobarbital, mebaral, mepindolol, mepiper ifene, mirfentanil, mirincamycin, miripirium, miriplatin, phenidol, mepiprazole, mepiroXol, mepitioStane, mepiv mirisetron, miristalkonium, miroprofen, mirosamicin, acaine, mepixanox, mepramidil, meprednisone, meprobam mirostipen, mirtazapine, misonidazole, misoprostol, mitem ate, meprochol, meproscillarin, meprotixol, meprylcaine, cinal, mitiglinide, mitindomine, mitobronitol, mitocarcin, meptazinol, medulidox, meduinol, meduitamium, meduita mitoclomine, mitocromin, mitoflaxone, mitogillin, mitogua Zine, meradimqate, menthyl anthranilate, merafloxacin, Zone, mitolactol, mitomalcin, mitomycin, mitonafide, mito meralein, meralluride, merbaphen, merbromin, mercaptom podozide, mitoquidone, mitosper, mitolane, mitotenamine, erin, mercaptopurine, mercuderamide, mercufenol, mercu mitoxantrone, mitoZolomide, mitradipide, mivacurium, matilin, mergocriptine, meribendan, merimepodib, mero mivobulin, mivotilate, mixidine, mizolastine, mizoribine, penem, mersalyl, mertialide, mesabolone, mesalamine, mobecarb, mobenzoxamine, mocimycin, mociprazine, meseclaZone, mesocarb, mesoridazine, mesipiperone, moclonemide, moctamide, modafinil, modaline, modecain mespirenone, mestanolone, mesterolone, mestranol, mesu ide, modipafant, moexipril, moexiprilat, mofarotene, dipine, mesulergine, mesulfamide, meSulfen, meSuprine, mofebtaZone, mofegiline, mofeZolac, mofloverine, mofoX metabromsalan, metbutethamine, metabutoxycaine, metac ine, mofuisteine, molfarnate, molinaZone, molindone, mol etamol, metaclazepam, metacresol, metaglycodol, metahexa racetam, molsidomine, mometaSone, monalaZone, mide, metalkonium, metalol, metamelfalan, metamfaZone, monatepil, monesin, monobenzone, monoctanoin, metamfenpramone, metampicillin, metanixin, metapramine, monometacrine, monophosphothiamine, monoxerutin, mon metaproterenol, metaraminol, metaxalone, metaZamide, telukast, monterelin, moperone, mopidamol, mopidralazine, metazide, matazocine, metbufen, meteneprost, metergoline, moprolol, moquizone, morantel, moraZone, morclofone, metergotamine, metescufylline, metesculetol, metesind, morforex, moricizine, morinamide, morniflumate, moro metethoheptazine, metformin, methacholine, methacycline, cromen, moroxydine, morpheridine, morphine, morSuxim methadone, methadyl acetate, methallenestril, methallibure, ide, mosapramine, mosapride, motapizone, motexafin, methalthiazide, methamphetamine, methandriol, meth motrazepam, motrtinide, moveltipril, moxadolen, moxalac androstenolone, methaniazide, methantheline, methaphe tam, moxaprindine, moxastine, moXaverine, moxazocine, nilene, methapyrilene, methaqualone, metharbital, methasty moxestrol, moxicoumone, moxidectin, moxifloxacin, moxi ridone, methazolamide, methdilazine, methenamine, lubant, moxipraquine, moxirapine, moxisylate, moXnida methenolone, metheptazine, methestrol, methetoin, Zole, moXonidine, moZavaptan, moZenavir, mubritnib, mupi methikcillin, mthimazole, methiodal, methiomeprazine, rocin, murabutide, muraglitazar, mureletecan, murocainide, methionine, methisaZone, methitural, methixene, methocar muZolimine, mycophenolic acid, mycophenolate mofetil, bamol, methocidin, methohexital, methopholone, methop my fadol, myrophine, myrtecaine, nabaZenil, nabilone, nabi rene, methoserpidine, methotrexate, methotrimeprazine, tan, naboctate, nabumetone, nacartocin, nadide, nadiofloxa methoxamine, methoXSalen, methoxyphedrine, methoxyphe cin, nadolol, nadoxolol, nafagrel, nafamo.stat, nafarelin, namine, methoxypromazine, methScopolamine, methSuxim nafazatrom, nafcaproic acid, nafcillin, nafenodone, ide, methyclothiazide, methyl aminolevulinate, methyl pal nafenopin, nafetolol, nafimidone, nafiverine, naflocort, nafo US 2009/0005722 A1 Jan. 1, 2009

mine, nafoxadol, nafoxidine, nafronyl, naftalofos, naftaZone, octatine, octaverine, octaZamide, octenidine, Octicizer, naftifine, naftopidil, naftoxate, naftypamide, naglivan, nalbu octimibate, octinoxate, octisalate, octocrylene, octodrine, phine, nalfurafine, nalidixic acid, nalmefene, nalmexone, octopamine, octotiamine, octreotide, octriptyline, octriazole, nalorphine, naloxone, naltrexone, naminidil, anminterol, odalprofen, odapipam, odiparcil, ofloxacin, oftormine, oftas namirotene, namoXyrate, nanafrocin, nandrolone, nant ceine, oglu fanide, olaflur, olamufloxacin, olanexidine, olan erinone, nantradol, napactadine, napamezole, naphazaoline, Zapine, olaquindox, olcegepant, oleandomycin, oletimol, naphthonone, napirimus, napitane, naproxime, naproxen, olmesartan, olopatadine, olpadronic acid, olpimedone, naproxol, napsagatran, naranol, barasin, naratriptan, narde olprinone, olradipine, olSalazine, oltipraz, olvanil, omaciclo toterol, naroparcil, natamycin, nateglinide, navuridine, nax Vir, omalizumab, omapartrilat, omeprazole, omidoline, omi agolide, naxaprosteine, naxifylline, nealbarbital, nebantan, gapil, omiloxetine, omoconazole, omonasteine, onapristone, nebidrazine, nebivolol, neboglamine, nebracetam, nebramy ondansetron, ontaZolast, ontianil, opanixil, opaviraline, opin cin, necopidem, nedaplatin, nedocromil, nefazodone, iazide, opipramol, opratonium, oraZamide, oraZipone, orbo nefiracetam, neflumozide, nefopam, nelarabine, neldaZosin, fiban, orbutopril, orconazole, orientiparcin, oritavancin, neleZaprine, nelfinavir, neltenexine, nelZarabine, nemadec ormaplatin, ormeloxifene, ormetoprin, ornidazole, orni tin, nemazoline, nemifitide, nemonapride, nemonoxacin, preessin, ornithine, ornoprostil, orotic acid, orotirelin, orpan nemorubicin, neocinchophen, neomycin, neostigmine, oxin, orphenadrine, ortataxel, orteteamine, osanetant, osater nepadutant, nepafenac, nepaprazole, nepicastat, nepinalone, one, oseltamivir, osemoZotan, osmadizone, ospennifene, nequinate, neramexane, neraminol, nerbacadol, neridronic ostreogrycin, OSutidine, otamixaban, otenZepad, oteracil, acid, nerisopam, nesapidil, nesiritide, nesosteine, nestifyl otilonium, otimerate, ouabain, oxabolon, oxabrexine, line, neticonazole, netilmicin, netivudine, netobimin, netogli oxaceprol, oxacillin, oxadimedine, oxafloZane, oxaflu taZone, netupitant, neutramycin, neviparine, nexeridine, mazine, oxagrelate, Oxalinast, oxaliplatin, oXamarin, oxam nexopamil, niacin, niacinamide, nialamide, niaprazine, etacin, oxamisole, oxaminiquinem oxanamide, Oxandrolone, nibroxane, nicafenine, nicainoprol, nicametane, nicanartine, oxantel, oxapadol, oxapium, oxaprazine, oxaprotiline, nicaraven, nicarbazin, nicardipine, nicergoline, niceritol, oxaprozin, oXcarbazole, oxatomide, oxazafone, oxazepam, niceverine, niclofolan, niclosamide, nicoboxil, nicoclonate, oxazidone, oxazolam, oxazorone, oXcarbazepine, oxdrala nicocodine, nicocortonide, nicocidodine, nicoduozide, Zine, Oxeclosporin, oxedrine, Oxeglitazar, OXeladin, oxen nicofibrate, nicofuranose, nifurate, nicogrelate, nicomol. dolone, oxepinac, oxetacillin, oxethazine, Oxetorone, nicomorphine, nicopholine, nicoracetam, nicorandil, nico oxfendazole, Oxfenicine, oxibendazole, oxibetaine, ociconi thiazone, nicotredole, nicoxamat, nictiazem, nictindole, Zole, oxidapamine, oxidronic acid, oxfentorex, oxifungin, nidroxyZone, nifedipine, nifekalant, nifenalol, nifenaZone, oxigluttione, oxilofrine, OXilorphan, oXimonam, OXindanac, niflumic acid, nifungin, nifuradene, nifuraldeZone, oxiniacic acid, Oxperomide, oxiracetam, oxiramide, oxiso nifuralide, nifuratel, nifuratrone, nifurdazil, nifurethazone, pred. Oxisuran, oxitefonium, oxitriptan, oxitriptyline, oxtri nifurfoline, nifurimide, nifurizone, nifurmazole, nifur ponium, OXmetidine, Oxodipine, oxogestone, oxolamine, merone, nifuroquine, nifuroxazide, nifuroxime, nifurpipone, oXolinic acid, oXomermazine, oXonazine, Oxophenarsine, nifurpirinol, nifurprazine, nifurquinazol, nifursemizone, Oxoprostol, oxpheneridine, oXprenoate, oXprenolol, Oxtriph nifursol, nifurthiazole, nifurtimox, nifurtoinol, nifurvidine, ylline, oxbenZone, Oxybutynin, oxychlorosene, oxycin nifurzide, nigludipine, nihydrazone, nikethamide, nileprost, chophen, oxyclipine, oxyclozanide, oxycodone, oxydipento nilprazole, niludipine, nilutamide, nilvadipine, nimaZone, nium, oxyfedrine, oxymesterone, oxymetazoline, nimeSulide, nimetazepam, nimidane, nimodipine, nimora oxymethalone, oxymorphone, oxypendyl, oxypertine, Zole, nimustane, neometacin, niperotidine, nipradillol, nipro oxyphenbutaZone, oxyphencyclimine, oxyphenisatin, faZone, nitavoline, nirdazole, nisbuterol, nisobamate, nisol oxyphenonium, oxypurinol, oxypurronium, oxyquinoline, dipine, nisoxetine, nisterime, nitarSone, nitazoxanide, oxyridazine, oxysonium, oxytetracycline, oxytocin, OZagrel, nitecapone, nithiamide, nitisinone, nitracrine, nitrafudan, oZagamicin, oZolindone, paclitaxel, pacrindolol, pactimibe, nitralamine, nitramisole, nitraduaZone, nitrazepam, nitrefa padimate A, padimate Q, pafenolol, pagoclone, paldimycin, Zole, nitrendipine, nitrocefin, nitroclofene, nitrocycline, palinavir, paliperidone, palivizumab. palmidrol, palmoxirate, nitrodan, nitrofurantoin, nitrofuraZone, nitromersol, nitro palonidipine, palonosertron, palosuran, parnabron, pamaque mide, nitromifene, nitroscanate, nitrovin, nitroXinil, nitroXo side, pamaquin, pamicogrel, pamidronic acid, panadiplon, line, nivaZol. nivimedone, nizatidine, nizofenone, noberas panamesine, pancopride, pancuronium, panipenem, tine, nocloprost, nocodazole, nofecainide, nogalamycin, panomifene, pantenicate, pantethine, panthenol, pantopra nolatrexed, nolinium, nolomirole, nolpitantium, nomege Zole, panuramine, papverine, papveroline, parachlorphenol, strol, nomelidine, nomifensine, nonabine, nonaperone, non paraflutizide, paramethadione, paramethasone acetate, apyrimine, nonathymulin, nonivamide, noracymethadol, nor paranitrosulfathiazole, paranyline, parapenzolate, para bolethone, norbudroine, norcholestenol, norclostebol, propamol, pararosaniline, paraxaZone, parbendazole, parc norcodeine, nordazepam, nordefrin, nordinone, norel etasal, parconazole, parecoxib, pareptide, parethoxycaine, gestromin, norepinepherine, norethandrolone, noethindrone, pargeverine, pargolol, pargyline, paricalcitol, paridocaine, norethynodrel, noreximide, norfenefrine, norfloxacin, norg parodilol, paromomycin, paroxetine, paroxypropione, esterone, norgestimate, norgestomet, norgestrel, norg parsalmide, particin, parvaquone, pasiniazid, pasireotide, estrieneone, norletimol, norlevorphenol, normethadone, nor patamostat, patupilone, paulomycin, paxamate, paZelliptine, morphine, norpipanone, nortetrazepam, nortopixantrone, paZinaclone, paZOxide, paZufloxacin, pecilocin, pecocycline, nortriptyline, norvinisterone, noSantine, noscapine, nosihep Pediarix R, pefloxocin, pegylated interferon alfa-2a, pegy tide, novobiocin, noxiptiline, noxytiolin, nuclomedone, lated interferon alfa-2b, pelanserin, peldesine, peliomycin, nuclotixene, nufenoXole, nupafant, nuvenZepine, nylestriol, pelitinib. pelitrexol, pelretin, pelrinone, pelubiprofen, nylidrin, nystatin, obidoxime, Ocaperidone, ocfentanil, ocilt pemedolac, pemerid, pemetrexed, pemirolast, pemoline, ide, ocinaplon, octacaine, octafonium, octamoxin, octapinol, penamecillin, penbutolol, penciclovir, pendecamine, pen US 2009/0005722 A1 Jan. 1, 2009 detide, penfluridol, penflutizide, pengitoxin, penicillamine, liride, piroheptine, pirolate, pirolazamide, piromidic acid, penicillin G, penicillin V, penimepicycline, penimocycline, piroXantrone, piroXicam, piroxicillin, piroXimone, pirozadil, penirolol, penmesterol, penoctonium, penprostene, pent pirprofen, pirquinozol, pirralkonium, pirsidomine, pirteni abamate, pentacynium, pentfluranol, pentagastrin, pentag dine, pitenodil, pitofenone, pituxate, pivagabine, pivampicil estrone, pentalamide, pentamethonium, pentamidine, penta lin, pivenfrine, pivopril, pivoxazepam, pixantrone, pizoty morphone, pentamoxane, pentamustine, pentapiperide, line, plafbride, plaunotol, plauracin, pleconaril, pleuromulin, pentapiperium, pentaquine, pentazocine, pentetic acid, pent plevitrexed, plicamuycin, plomestane, pobilukast, podilfen, reotide, penthienate, penthrichloral, pentiapine, pentifylline, podofilox, poldine, polymixin Sulfate, polythiazide, pomisar pentigetide, pentisomicin, pentisomeide, pentizidone, pento tan, ponalrestat, ponaZuril, ponfibrate, porfiromycin, posa barbital, pentolinium, pentolonium, pentomone, pentopril, conazole, posatirelin, posiZolid, poskine, practolol, pradol pentorex, pentosalen, pentostatin, pentoxifylline, pentox foxacin, prajmalium, pralatrexate, pralidoxime, pralmorelin, yverine, pentrinitrol, pentylenetetraZol, peplomycin, pepsta pralnacasan, pramipexole, pramiracetam, pramoxine, pramp tin, peraclopone, peradoxime, perafensine, peralopride, per ine, pranazepide, pranidipine, prankulast, pranolium, prano amivir, peraquisin, perastine, peratizole, perazine, profen, pranosal, prasterone, praSugrel, pratosartan, pravado perbufylline, perfomedil, perfosfamide, pegolide, perhexil line, pravastatin, praxadine, praZarelix, prazepam, prazepine, ine, periciazine, perifosine, perimetazine, perindopril, perin praziquantel, praZitone, prazocillin, prazosin, preclamol. doprilat, perisoxal, perlapine, permethrin, peroSpirone, per prednazate, prednazoline, prednicarbate, prednimustine, phenazine, persilic acid, perZinfotel, petrichloral, peXantel, prednisolamate, prednisolone, prednisone, prednival, pred phanquone, phenacaine, phenacemide, phenacetin, phenac nylidene, pregabalin, pregnadiol, pregnenolone, premafloxa tropinium, phenadoxone, phenaglycodol, phenamaZoline, cin, premazepam., prenalterol, prenisteine, prenoverine, phenampromide, phenaphthazine, phenarsone, phenazocine, prenoxdiazine, prenylamine, pretamazium, pretiadoil, pre phenaZopyridine, phenbutaZone, phencarbamide, phencycli Vnarg prezatide, pribecaine, pridefine, prideperone, pridinol, dine, phendimetrazine, phenelzine, pheneridine, phenethicil prifelone, pri?inium, prifuroline, pilocalne, primaperone, pri lin, pheneturide, phenylglutarimide, phenicarbazide, phenin maquine, primidolol, primidone, primycin, prinomastat, pri damine, phenindione, pheniprazine, pheniramine, nomide, prinoXodan, pristinol, pristinamycin, prizidilol. phenisonone, phenmetrazine, phenobarbital, phenobutiodil, proadifen, probarbital, probenecid, probicromil, probucol, phenomorphan, phenothiazine, phenothrin, phenoxyben procainamide, procaine, procarbazine, procaterol, prochlor Zamine, phenoxypropazine, phenprobamate, phenprocou perazine, procinolol, procinonide, proclonol, procromil, pro mon, phenpromethamine, phensuximide, phentermine, phen cyclidine, procymate, prodeconium, prodilidine, prodipine, tolamine, phenyl aminosalicylic acid, phenylalanine, prodolic acid, profadol, profexalone, proflavine, phenylbutaZone, phenylephrine, phenylpropanolamine, phe proflazepam, progabide, progesterones, proglumetacin, pro nylthiolone, phenyltoloxamine, pheny racillin, phenyramidol. glumide, proheptazine, proligestone, praline, prolintane, pro phenytoin, pnetharbital, pholcodine, pholedrine, phoxim, lonium, promazine, promegestone, promestriene, promet phthalofyne, phthylsulfacetamide, phthalylsulfamethiazole, hazine, promolate, promoxolane, prontalol, propacetamol. phthalylsulfathiazole, physostigmine. Phytic acid, phytona propafenone, propagermanium, propamidine, propanidid, dione, pibaxizine, pibecarb, piberaline, piboserod, pibroZe propanocaine, propantheline, proparacaine, propatyl nitrate, lesin, pibutidien, picafibrate, picartamide, picenadol, picil propazolamide, propenidazole, proprintofylline, propen orex, piclaimilast, piclonidine, piclopastine, picloxydine, Zolate, properidine, propetamide, propetamfos, propetandrol, picobenzide, picodralazine, picolamine, piconol, picoperine, propicillin, propikacin, propinetidine, propiomazine, propi picoplatin, picoprazole, picotamide, picotrin, picumast, picu ocaine, propiram, propisergide, propiverine, propizepine, meterol, pidobenzone, pidolacetamol, pidolicaica, pidoti propofol, propoxate, propoXur, propoxycaine, pro mod, pifarnine, pifinate, pifexole, piflutiXol, piketoprofen, poxyphene, propranolol, propyl docetrizoate, propyl gallate, pildralazine, pilocarpine, pilsicainide, pimagedine, pime propylhexedrine, propyliodone, propylthiouracil, propyper clone, pimecrolimus, pimefylline, pimelautide, pimetacin, one, propyphenaZone, propyromazine, produaZone, pro pimethixene, pimetine, imetremide, pimilprost, piminodine, quinolate, prorenoate, proroXan, prScillardin, prospidium, pimobendan, pimonidazole, pimozide, pinacidil, pinadoline, prostalene, proSulpride, proSultiamine, proterguride, pro pinafide, pinaverium, pinazepam, pincainide, pindolol. theobromine, prothipendyl, prothixene, protiofate, protiona pinokalant, pinolcaine, pinoxepine, pioglitaZone, pipacy mide, protirelin, protizinic acid, protokylol, protoporphyrin, cline, pipamazine, pipamperone, pipazethate, pipebuZone, protriptyline, proXZole, proxibarbal, proxibutene, proxicro pipecuronium, pipemidicacid, pipendoxifene, pipenZolate, mil, proxifeZone, proXorphan, proxymetacaine, proxyphyl pipequaline, piperacetazine, piperacillin, piperamide, piperi line, proZapine, prucalopride, prulifloxacin, pruvanserin, dolate, piperilate, piperocaine, piperonyl butoxide, piper pseudoephedrine, pumafentrine, pumaprazole, pumitepa, oxan, piperphenidol, piperylone, pipobroman, pipoctanone, pumosetrag, puromycin, pyrabrom, pyrantel, pyrathiazine, pipofezine, piposulfan, pipotiazine, pipOXizine, pipoxolan, pyrazinamide, pyrazofurin, pyricarbate, pyridarone, pyridi pipradimadol, pipradrol, pipramadol, pipratecol, piprinhydri nol, pyridofylline, pyridostigmine, pyridoxal, pyridoxamine, nate, pipocurarium, piprofurol, piproZolin, piquindone, pyridoxine, pyrilamine, pyrimethamine, pyrimate, pyrino piquizil, piracetam, pirandamine, pirarubicin, piraxelate, line, pyrithione, pyrithyldione, pyritidium, pyritinol, pirzmonam, piraZolac, pirbenicillin, pirbuterol, pirdonium, pyrophenindane, pyrovalerone, pyroxamine, pyrrobutamine, pirenoxine, piremperone, pirezepine, pirepolol, piretanide, pyrrocaine, pyrrolifene, pyrroliphene, pyrrolnitrin, pyrroX pirfenidone, pirbendil, piridicillin, piridocaine, piridoxilate, ane, pyrvinium, pytamine, quadazocine, quadrosilan, piridironic acid, pirifibrate, pirimiphos-ethyl, pirindazole, quatacaine, quaZepam, quaZinone, quaZodine, quaZolast, pirinixic acid, pirinixil, piriprost, piriqualone, piriSudanol, quetiapine, quifenadine, quiflapon, quillifoline, quiloStig piritramide, piritrexin, pirlimycin, pirlindole, pirmagrel, pir mine, quinacainol, quinacillin, quinacrine, quinagolide, menol, pimabine, piroctone, pirodavir, priodomast, pirog quinaldine blue, quinapril, quinaprilat, quinazosin, qui US 2009/0005722 A1 Jan. 1, 2009

bolone, quincarbate, quindecamine, quindonium, quindoxin, sampimod, sematilide, Semaxanib, semduramicin, semor quinelorane, quinestradol, quinestrol, quinethaZone, quineto phone, Semotiadil, Semustine, SenaZodan, Seocalcitol, sepa late, quineZamide, quinfamide, quingestanol acetate, Zonium, Seperidol, sepimostat, seprilose, seproxetine, quingestrone, quinidine, quinine, quinotolast, quinpirole, sequifenadine, seratrodast, Serazapine, serfibrate, Sergolex quinterenol, quitiofos, quinuclium, quinupramine, quinupris ole, Sermetacin, sertindole, Sertraline, setastine, Setzindol, tin, quipazine, quisultazine, rabeprazole, raclopride, racto setipafant, setiptiline, Setoperone, sevelamer, Sevitropium, pamine, radafaxine, rafoxanide, ragaglitazar, ralitoline, ral sevopramide, seZalamide, Sagoside, sibenadet, Sibopirdine, oxifene, raltitrexed, raluridine, ramatroban, ramciclane, Sibrafiban, Sibutramine, siccanin, sifrprazine, SiguaZodan, ramelteon, ramifenaZone, ramipril, ramiprilat, ramixotidine, silandrone, sildenafil. Silibinin, Silcristin, sildianin, silodosin, ramnodigin, ramnoplanin, ramorelix, ramosetron, ranelic silodrate, silperisone, siltenZepine, Simendan, simetride, sim acid, ranimustine, ranimycin, ranirestat, ranitidine, ranolaine, fibrate, simtraZene, simvastatin, sincalide, sinefungin, sini rapacuronium, rasagiline, rasburicase, rathyronine, ravu trodil. Sintropium, sipatrigine, siramesine, Siratiazem, siroli conazole, raZaxaban, razinodil, raZobazam, razoxane, rebim mus, Sisomicin, sitafloxacin, Sitalidone, Sitamaquine, astat, reboxetine, recainam, reclazepam, recombinant Factor sitaxentan, sitofibrate, sitoglusoide, sivelestat, Soblidotin, VIII, recombinant human insulin, recothrome, regadenoson, Sobuzoxane, Solabegron, Solifenasin, Solimastat, Solpecainol, reglitazar, relcovaptan, relomycin, remacemide, remifenta Solypertine. Somatadine. Somatostatin, Somatropin, Somatat nil, remikiren, remiprostol, remoxipride, renanolone, rent ropin, Soneclosan, Sonepiprazole, sopitazine, Sopromidine, iapril, renzapride, repaglinide, reparixin, repinotan, repiri Soquinolol, Sorafenib, Soraprazan, Sorbinicate, Sorbinil, nast, repromicin, reproterol, rescimetol, rescinnamine, Sorivudine, Sornidipine, Sotalol, Soterenol, spaglumic acid, resequinil, reserpine, residuimod, resocortol butyrate, resor sparfloxacin, sparfosate, sparsomycin, Sparteine, spectino antel, resorcinol, retapamulin, retelliptine, retigabine, retinol, mycin, spiclamine, spiperone, spiradoline, spiramide, spira revaprazan, revatropate, revenast, reviparin, revizinone, mycin, spirapril, spiraprilat, spirendolol, spirgetine, spirilene, revospirone, ribavirin, riboflavin, riboprine, ribostamuycin, spiriprostil, Spirofylline, spirogermanium, Spiroglumide, ricasetron, ridazolol, ridogrel, rifabutin, rifalazil, rifametane, spiromustine, spironolactone, Spiroplatin, Spirorenone, spiro rifamexil, rifamide, rifampin, rifapentine, rifaximin, rilapine, triazine, spiroXasone, SpiroXatrine, SpiroXepin, Spizofurone, rilmakalim, rilmazafone, rillmenidine, rilopiroX, riloZarone, Sprodiamine, squalamine, squalane, stacofylline, stillimycin, rillpovorine, riluzole, rimantadine, rimazolium, rimcazole, Stannsoprfin, stanolone, stanoaolol, stavudine, Stearylsulfa rimexolone, rimiterol, rimonabant, rimoprogin, riodipine, mide, Steffimycin, Stenbolone, strpronin, Stercuronium, Stev rioprostil, ripazepam, ripisartan, risarestat, risedronicacid, aladil, stibamine, stibophen, stilbamidine, stilbazium, stillo risedronate, risocaine, risotilide, rispenzepine, risperidone, nium, Strimazole, Stiripentol, stirocainide, Stirofos, ristianol, ristocetin, ritanserin, ritometan, ritipenem, ritobe streptomycin, streptonicozid, Streptonigrin, Streptozocin, gron, ritodrine, ritolukast, ritonavir, ritropirronium, ritrosul styramine, SubathiaZone, Subendazole, Succinylcholine, Suc fan, rituximab, rivaroXaban, rivastigmine, rivoglitaZone, riza cinylsulfathiazole, Succisulfone, Suclofenide. Sucralfate, triptan, robalZotan, robenidine, rocastine, rocepafant, Sucralose. Sucrose octaacetate. SucroSufate, Sudexanox, rociclovir, rocuronium, rodocaine, rodorubicin, rofecoxib, Sudoxicam, Sufenatil, Sufotidine, Sufugolix, Sugammadex, rofelodine, rofileponide, roflumilast, rogletimide, rokitamy Sulamserod, Sulazepam, SulaZuril, Sulbactam, Sulbenicillin, cin, rollafagrel, roletamide, rolgamidine, rolicyclidine, roli Sulbenox, Sulbentine, Sulbutiamine, Sulclamine, Sulconazole, cyprine, rolipram, rollitetracycline, rolodine, rolziracetam, Sulfabenz, Sulfabenzamide, Sulfabromomethazine, Sulfacar romazarit, romergoline, romifenone, romifidine, romurtide, bamide, Sulfacecole, Sulfacetamide, Sulfachlorpyridazine, ronactolol, ronidazole, ronifibrate, fonipamil, runnel, ropin Sulfachrysoidine, Sulfaclomide, Sulfaclorazole, Sulfaclozine, irole, ropitoin, ropivacaine, ropizine, roquinimex, rosapros Sulfacytine, Sulfadiazine, Sulfadimethoxine, Sulfadoxine, Sul tol, rosaramicin, rose bengal, rosiglitaZone, roSoxacin, ros faethidole, Sulfaguanidine, Sulfaguanole, Sulfalene, Sulfa tafuroxin, rostaporfin, rosterolone, rosuvastatin, rotamicillin, loxic acid, SulfamaZone, Sulfamerazine, Sulfameter, Sulfamet rotigotine, rotoxamine, rotaxate, roXadimate, roXarsone, hazine, sulfamethizole, Sulfamethoxazole, roXatidine acetate, roXibolone, roxifiban, roXindole, roXithro Sulfamethoxypyridazine, Sulfametmidline, Sulfametrole, Sul mycin, roXolonium, roXoperone, rubitecan, rubOXistaurin, famonomethoxine, Sulfamoxole, Sulfanilamide, Sulfanilate, rufinamide, rufloxacin, rupatadine, rupintrivir, rutamycin, Sulfaanitran, Sulfaperin, Sulfaphenazole, Sulfaproxyline, Sul ruvaZone, ruzadolane, Sabarubicin, sabcomeline, sabeluzole, fapyridine, Sulfaquinoxaline, Sulfarsphenamine, Sulfasala Sabiporide, Saccharin, Safingol, Safirinol, Sagandipine, salac Zine, Sulfasomizole, SulfaSuccinamide, Sulfasymazine, Sul etamide, Salafibrate, Salantel, Salazodine, Salazosulfadimi fathiazole, Sulfathiourea, Sulfatolamide, Sulfatroxazole, dine, Salazosulfamide, Salazosulfathiazole, salbutamol, Sal Sulfatrozole, Sulfazamet, Sulfinaolol, Sulfinpyrazone, Sul caprozoic acid, Salcolex, Salethamide, Salflucerine, salicyl firam, Sulfisomidine, Sulfisoxazole, Sulfobromophthalein, alcohol, Salicylamide, Salicylic acid, Salinazid, salinomycin, Sulfonterol, Sulforidazine, Sulfosalicylic aica, Sulfoxone, Sul salmefamol, Salmeterol, Salmisteine, Salnacedin, salproto crinat, Sulindac, Sulisatin, Sulisobenzone, Sulmarin, Sulma side, Salsalate, Sameridine, Samixogrel, Sampatrilat, Sampir Zole, Sulmepride, Sulnidazole, Sulocarbilate, Suloctidil, Sulo tine, Sancycline, Sanfetrinem, sanguinarium, Saperconazole, dexide, Sulofenur, Sulopenem, Sulosemide, Sulotroban, Saprisartan, sapropterin, saquinavir, Sarafloxacin, Sarakalim, Suloxifen, Sulpiride, Sulprosal, Suiprostone, Sultamicillin, Sul Saralasin, sarcolysin, sardomozide, Saredutant, Saripedem, tiame, Sultopride, Sultosilic acid, Sultroponium, Sulukast, Sul SSarizotan, Sarmazenil, Samoxicillin, Sarpicillin, Sarpogre Verapride, Sumacetamol, Sumanirole, Sumarotene, Sumatrip late, Saterinone, satigrel, satranidazole, satraplatin, savipra tan, Sumetizide, Sunagrel, Suncillin, Sunepitron, Supidimide, Zole, savoxepin, scopafungin, scopinast, Scopolamine, Secal Supalast, Suproclone, Suprofen, Suramin, Suricainide, Suri ciferol, seclaZone, secnidazole, secobarbital, securinine, clone, SuritoZole, Suronacrine, Susalimod, SuXemerid, Sux Sedecamycin, Sedoxantrone, Seganserin, Segesterone, Seg ethonium, SuxibuZone, Symclosene, Synetine, tabilautide, litide, Selamectin, Selgiline, selfotel, Soldenoson, selprazine, tabimorelin, tacalcitol, tacapenem, tacedinaline, taclamine, US 2009/0005722 A1 Jan. 1, 2009 16 tacrine, tacrolimus, tadalafil, tafluposide, taglutamine, tago codar, timefurone, timegadine, timelotem, timepidium, timi rizine, talampanel, talampicillin, talaporfin, talastine, talb perone, timirdine, timobesone acetate, timofibrate, timolol. utal, thaeranol, talibegron, talinolol, talipexole, talisomycin, timonacic, timoprazole, tinabinol, tinazoline, tinidazole, tallimustine, talmetacin, talmetoprim, talnetant, talniflumate, tinisulpride, tinofedrine, tinoridine, tiocarlide, tioclomarol, talopram, talsalate, toloXimine, talsaclidine, talsupram, tioconazole, tioctilate, tiodaZosin, tiodonium, tiomergine, taltirelin, taltobulin, taltrimide, taludipine, talviraline, tiomesterone, tioperidone, tiopinate, tiopronin, tiopropam tameridone, tameticillin, tametraline, tamibarotene, tamiti ine, tioSpirone, tiotidine, tiotropium, tioxacin, tioXamast, nol, tanolarizine, tamoxifen, tampramine, tamsulosin, tioxaprofen, tioxidazole, tioXolone, tipentosin, tipepidine, tanaproget, tandamine, tandospirone, tandutinib, taniplon, tipetropium, tipifarnib, tipindole, tipranavir, tipredane, tipre tanomastat, tapentadol, taprizosin, taprostene, tarazepide, nolol, tiprinast, tiprodil, tiprostanide, tiportimod, tiqueside, tariquindar, tasosartan, tasuldine, taurolidine, tauromustine, tiquinamide, tiquizium, tiracizine, tirapazamine, tiratricol, tauroselcholic acid, taurosteine, tazadolene, tazanolast, taZ tirilazad, tirofiban, tiropramine, tisartan, tisocalcitate, arotene, taZaSubrate, tazeprofen, tazifylline, taZiprinone, tisocromide, tisopurine, tisoquone, tivanidazole, tiviciclovir, taZobactam, tazofelone, tazolol, tazometime, tebanicline, tivirapine, tixadil, tixanox, tiXocortol, tiZabrin, tizanidine, tebatizole, tebipenem, tebufelone, tebuquine, tecadenoson, tizolemide, tizoprolic acid, tobicillin, toborinone, tobramy tecalcet, tecastemizole, teclthiazide, teclozan, tedisamil, tefa cin, tocainide, tocamphyl, tocladesine, tocofenoxate, tocofi Zoline, tefenperate, teflufazine, teflutiXol, tegafur, tegaserod, brate, tocophersolan, todralazine, tofenacin, tofetridine, teglicar, teicopamin, telavancin, telbivudine, telenzepine, tofimilast, tofisoline, tofisppam, tolafentrine, tolamolol. telinavir, tellithromycin, telmesteine, telmisartan, teloX tolaZamide, tolboxane, tolbutamide, tolvapone, tolciclate, antrone, teludipine, temafloxacin, temarotene, tematropium, toldimfos, tolfamide, tolfenamic acid, tolgabide, tolimidone, temazepam, temefos, temelastine, temiverine, temocapril, tolindate, toliodium, toliprolol, tolmesoxide, tometin, tolnaf temocaprilat, temocillin, temodox, temoporfin, temozolo tate, tolnapersine, tolnidamine, toloconium, tolonidine, tolo mide, temisirolimus, temurtide, tenamfetamine, tenatopra nium, toloxatone, toloxychlorinol, tolpadol, tolpentamide, Zole, tendamistat, tenidap, tenilapine, teniloxazine, tolperisone, tolpiprazole, tolpronine, tolpropamide, tolpyrra tenilsetam, teniposide, tenivastatin, tenocyclidine, tenofovir, mide, tolduinzole, tolrestat, tolterodine, toltraZuril, tolu tenofovir disoproxil, tenonitrozole, tenosal, tenosiprol, fazepam, tolvaptan, tolycaine, tomeglovir, tomelukast, tomo tenoxicam, tenylidone, teoprantil, teoprolol, tepirindole, tep glumide, tomoxiprole, tonabersat, tonazocine, topilutamide, oxalin, teprenone, teprotide, teraZosin, terbequinil, terbin topiramate, topixantrone, topotecan, toprilidine, topterone, afine, terbogrel, terbucromil, terbufirol, terbuficin, terbuprol, toquizine, torbafylline, torcetrapib, torcitabine, toremifene, terbutaline, terciprazine, terconazole, terdecamycin, terestig toripristone, torsemide, tosagestin, tosifen, toSufloxacin, mine, terfeadine, terflavoxate, terfluranol, terguride, teri to Sulur, trabectedin, traboXopine, tracazolate, tradecamide, flunomide, terikalant, teriparatide, terizidone, terlakiren, ter tralonide, tramadol, tramaZoline, trandolapril, trandolaprilat, lipressin, temidazole, terodiline, terofenamate, teroxalene, tranexamic acid, tranilast, transcainide, trantelinium, trany teroxirone, tertatolol, tesaglitazar, tesicam, tesimide, tesimil cypromine, trapencaine, trapidil, trastuzumab, travoprost, ifene, tesofensine, testolactone, testosterone, tetomilst, tetra traxanox, traxoprodil, traZitiline, trazium, traZodone, traZolo barbital, tetrabenazine, tetracaine, tetracycline, tetrahydroZo pride, trebenzomine, trecadrine, trecetilide, trefentanil, trel line, tetramethrin, tetramisole, tetraxetan, tetrazepam, narizine, treloxinate, trenbolone, trengestone, trenizine, treo tetraZolast, tetriprofen, tetrofosmin, tetronasin, tetroquinone, Sulfan, trepibutone, trepipam, trepirium, treprostinil, tetroxoprin, tetrydamine, teverelix, texacromil, tezacitabine, treptilamine, terquisin, tresperimus, trestolone, trethinium, tezosentan, thalidomide, thebacon, thenalidine, thenium, the trethocanoic acid, tretinoin, tretinoin tocoferil, tretoquinol, nyldiamine, theobromine, theodrenaline, theofibrate, theo triacetin, triafungin, triamcinolone, triamcinolone acetonide, phylline, thiabendazole, thaicetarsamide, thialbarbital, thia triamcinolone benetonide, triamcinolone furetonide, tri mazole, thiamine, thiamiprine, thiamphenicol, thamylal, ampyZine, triamternem triaziquone, triazolam, tribendilol. thiaZesim, thiazinamium, thiazolsulfone, thiethyperazine, tribenoside, tribromsalan, tribuZone, tricaprilin, tricetamide, thihexinol ethylbromide, thimerfonate, thimerosal, thio trichlorfon, trichlormethiazide, trichlomethine, triciribine, colchicoside, thioctic acid, thiofuradene, thioguanine, thio triclabendazole, triclacetamol, triclazate, triclobisonium, tri hexamide, thioinosine, thiopental, thiophanate, thiopro clocarban, triclodazol, triclofenol, triclofos, triclofyllin, tri pazate, thioproperazine, thioridazine, thiosalan, thiostrpton, clonide, triclosan, tricyclamol, tridihexethyl, tridolgosir, tri thiotepa, thiotetrabarbital, thiothixene, thiphenamil, thiphen entine, triethylenemelamine, trifenagrel, trifeZolac, triflocin, cillin, thiram, thonzonium, thonZylamine, thoZalinone, threo triflubazam, triflumidate, triflomeprazine, trifluperazine, tri nine, thymocartin, thymoctonan, thymol, thymopentin, thy fluperidol, triflupromazine, trifluidine, triflusal, trifosmin, tri motrinan, thyromedan, thyropropic acid, thyroxin, tiacrilast, gevolol, trihexylpheidyl, triletide, triloStane, trimaZosin, tri tiadenol, tiafibrate, tiagabine, tiamenidine, tiametomnium, mebutine, trimecain, trimedoxime, trimegestone, tiamulin, tianafac, tianeptine, tiapamil, tiapirinol, tiapride, trimeperidine, trimeprazine, trimetazidine, trimethadone, tri tiaprofenic acid, tiaprost, tiaramide, tiazofurin, tiaZuril, tia methamide, trimethaphan, trimethidinium, trimethobenza balosin, tibeglisene, tibenelast, tibenzate, tibeZonium, mide, trimethoprim, trimetozine, trimetrexZate, trimexiline, tibolone, tibric acid, tibrofan, ticabesine, ticalopride, ticarbo trimipramine, trimoprostil, trimoxamine, trioxifene, triox dine, ticarcillin, ticlatone, ticlopidine, ticolubant, ticrynafen, salen, tripalmitin, tripamide, triparanol, tripelennamine, tri tidembersat, tidiacic acid, tiemonium, tienocarbine, tieno platin, triprolidine, triptorelin, tritoqualine, trixolane, tri pramine, tienoxolol, tifemoxone, tifenaZoxide, tiflamizole, Zoxime, trocimine, troclosene, trodusquemine, trofosfamide, tiflorex, tifluadom, tiflucarbine, tiformin, tifurac, tigecycline, troglitaZone, troleandomycin, tromanttadine, tropabazate, tigemonam, tigestol, tigloidine, tillargenine, tiletamine, tili tropanserin, tropapride, tropatepine, tropenZiline, tropicam dine, tiliquinol, tilisolol, tilmacoxib, tilmicosin, tilnoprofen, ide, tropigline, tropirine, tropisetron, tropodifene, troquida tilomisole, tillorone, tilozepine, tilsuprost, tiludonic acid, tim Zole, trospectomycin, trospium, trovafloxacin, troVirdine, US 2009/0005722 A1 Jan. 1, 2009

troxacitabine, troXerutin, troXipide, troXolamide, troXonium, transport was insufficiently high enough to deliver therapeu troxypyrrolium, truXicurium, truXipicurium, tryparsamide, tic levels can now frequently be used transdermally because tubocurarine, tubulozole, tucaresol, tuclazepam, tulathromy larger areas of the body can be employed because the skin cin, tulobuterol, tulopafant, turosteride, tuvatidine, tybamate, contacting adhesive usually employed in transdermal prod tykerb, tylosin, tymazolin, tyropanoate, tyrosine, tyrothricin, ucts can be avoided. Thus, the type of active agent that can be ubenimex, ubidecarenone, ubisindine, ufenamate, ufiprazole, employed in this context with the present invention is virtu uldazepam, ulifloxacin, uliprisnil, umespirone, undecylenic ally unlimited (as the foregoing list Suggests). In transdermal acid, unoprostone, upenazime, upidosin, uracil, uracil mus administration of active agents in this context, reservoir type tard, urapidil, uredepa, uredofos, urefibrate, ursodiol. transdermals, standard monolith type transdermals (where urulcholic acid, utibapril, utibaprilat, Vadocaine, Valaciclovir, the monolith is an adhesive formulation) and monolithic Valconazole, Valdecoxib, Valdetamide, Valdipromide, Vale transdermals where the monolith is non-skin-adhesive (adhe thamate, Valganiciclovir, Valine, Valnemulin, Vlanoctamide, sive, but not to skin) are all suitable. The present invention is valofane, Valomaciclovir, Valperinol, Valproate, valproate particularly advantageous with non-skin-contacting-adhe hemisodium (Depakote(R) valproic acid, valpromide, Valro sive transdermals and reservoir type transdermals precisely cemide, valrubicin, Valsartan, Valorcitabine, Valtrate, Vamica because the skin contacting adhesive can be avoided. How mide, Vancomycin, Vandetanib, Vaneprim, Vanitiolide, Vanox ever, where a standard transdermal adhesive is desired, it can erine, Vanyldisulfamide, Vapiprost, Vapreotide, Vardenafil. be used as long as the device is constructed so that there is a Varenicline, Varespladib, Vatalanib, Vatanidipine, Vebufloxa skin-non-adherent layer or material between the skin and the cin, Vecuronium, Vedaclidine, Vedaprofen, Velaresol, Velna adhesive when the device is in use so that the skin is not in crine, Venlafaxine, Venritidine, Verodoline, Veralipride, Vera contact with a skin adherent adhesive. pamil, Verazide, Verilopam, Verlukast, Verofylline, 0060. In the particular embodiment used for circumcision versetamide, verteporfin, Vesnarinone, Vestipitant, Vetrabu wound healing in infants or pre-mature infants, clotting may tine, Vidarabine, vigabatrin, VilaZodone, Vildaglipin, Vilox not take place as efficiently as would in older children or azine, vinbarbital, vinblastine, vinburnine, Vincamine, Vin adults. Thus, impregnating the central region 8 of device 1 canol, Vincofos, Vinconate, Vincristine, Vindeburnol, with clotting Factors such as one or more of those set forth vindesine, Vinpidine, Vinflunine, Vinformide, Vinfosiltine, above, especially Factor VIII, Factor XII, and/or vitamin Kor Vinglycinate, Vinleucinol, Vinleurosine, Vinmegallate, others known to be generally of use in promoting clotting Vinorelbine, Vinpocetine, Vinpoline, Vinrosidine, Vintiamol. helps to promote proper clotting and begin the healing pro Vintoperol, vintriptol, vinylbital, Vinzolidine, viomycin, cess. Such bandages having clotting factors either impreg Viprostol, Vicqualine, Vicquidil, Virginiamycin, viridofulvin, nated therein or merely applied to the central portion skin ViroXime, Visnadine, Visnafylline, Vofopiitant, Voglibose, contacting Surfaces are also of use in treating wounds of Volazocine, Volpristin, Voriconazole, Vorozole, Voxergolide, known hemophiliacs. In such embodiments, the invention Xaliproden, Xamoterol, Xanomeline, Xanoxic acid, Xanthinol, devices are significant improvements over the artin that while Xantifibrate, Xantocillin, Xanto?yl palmitate, Xemilofiban, allowing for rapid local administration of various clotting Xenalipin, Xenazoic acid, Xenbucin, Xenipentone, Xenothio factors, the bandages can be readily removed and changed rate, Xenygloxal, Xenylhexenicacid, Xeny tropium, Xibenolol. without disturbing the clot so formed. Other patient popula Xibornol, Xidecaflur, Xilobam, Ximelagatran, Ximoprofen, tions for which Such embodiments are particularly advanta Xinidamine, Xinomiline, sipamide, Xipranolol. Xorphanol, geous include diabetics, those with compromised immune Xylamidine, Xylazine, Xylocoumarol. Xylometazoline, Xylox systems (such as transplant patients, dialysis patients, those emine, yohimbic acid, Zabicipril, Zabiciprilat, Zacopride, having radiation therapy or chemotherapy, radiation poison Zafirlukast, Zafiuleptine, Zalcitabine, Zalderide, Zaleplon, ing patients, and those presenting with HIV positive infec Zalospirone, Zalitidine, Zaltoprofen, Zamifenacin, Zanamivir, tion), and those with arthritis. The more rapid closing of the Zanapezil, Zankiren, Zanoterone, Zapizolam, Zaprinast, Zard wound in these embodiments helps to protect against infec averine, Zatebradine, Zatosetron, Zelandopam, Zenarestat, tion (extremely important for poor healers such as diabetics Zenazocine, Zeniplatin, Zepastine, Zeranol, Zetidoline, Zidapa and immunocompromised patients and for use in settings mide, Zidometacin, Zidovudine, Zifrostilone, Zilantel, Zilas where antibiotic resistant infectious organisms are likely corb, Zileuton, Zilpaterol, Zimeldine, Zimidoben, Zindotrine, present) and the design of the securement means as not being Zindoxifene, Zinconazole, Zinostatin, Zinterol, ZinviroXime, attached along the circumference, but rather protruding radi Zipeprol, Ziprasidone, Zocainone, Zofenopril, Zofenoprilat, ally is of considerable benefit to those having arthritis in the Zoficonazole, Zolamine, Zolasartan, Zolazepam, Zolendronic hands or in the body part being bandaged. Similar application acid, (ZoledronateR), Zolenzepine, Zollertine, Zolimidine, is suitable for other situations where clotting and homeostasis Zoliprofen, Zolmitriptan, Zoloperone, Zolpidem, Zomebazam, is being maintained. In situations where deep wounds are Zomepirac, Zometapine, Zonampanel, ZonicleZole, involved (such as, without limitation, battlefield injuries, Zoniporide, Zonisamide, Zopiclone, Zopolrestat, Zorbamycin, emergency rooms, etc.), the devices of the present invention Zorubicin, ZoSuquidar, Zotepine, ZoticaSone, Zoxazolamine, can be configured to deliver large quantities of homeostatic Zucapsaicin, Zuclomiphene, Zuclopenthixol, and Zylo agents quickly and over a prolonged period by having Such furamine, as well as pharmaceutically acceptable salts agents in multiple layers of biodegradable and/or hydrolyZ thereof, and mixtures thereof. able films such that the serum or other body fluid water 0059. In contexts where open wounds are not at issue, but contact acts to hydrolyze such films or to dissolve such mate bandages are used for either topical or transdermal adminis rials so that they can reach further into the wound quickly. tration of compounds, the active agents that can be present 0061 The skin contacting surface of the central portion 8 can be virtually any active agent that is useful topically or can be replaced in whole or in part by a transdermal device transdermally. In addition, active agents which could not be which can be adhered to the innermost wall within central previously administered transdermally because the drug portion 8 by a suitable adhesive, or the transdermal formula US 2009/0005722 A1 Jan. 1, 2009 tion can be merely impregnated into the portions 20A, 20B, or patient and have less of an undesired impact on the healing linings 17 and 18. Since the devices of the present invention process while changing bandages than bandages which are can cover significant areas of the body because they do not use secured circumferentially. skin-contacting adhesives (or if they do, such adhesive is 0064. In a further embodiment of the invention, one or prevented from contacting the skin), they can be used to more of the layers described above may actually be a multi administer active agents with lesser amounts of permeation laminate itself. A general exploded view of one embodiment enhancers than other transdermal devices known in the art, of this type is shown in FIG.20 where the device is laid outflat preferably Substantially without penetration enhancers, most with layers 40-43 constituting a top portion (inclusive of preferably without any. Furthermore, since the area of trans securement means 44a and 44b) and layers 40a-43b consti dermal delivery can be large, the administration of drugs that tuting a bottom portion. Layers 43 and 43a are a skin-non are poorly administrable transdermally are possible to a adherent layer and will be the skin contacting surface of the greater degree, and the rate of permeation can be much lower present invention. Layers 42 and 42a are an absorbent layer. so that prolonged transdermal administration of low flux is Layers 41 and 41a are a waterproof material, and layers 40 feasible. Unlike other transdermal devices known in the art, and 4.0a are a decorative layer. Of these, the critical layer to the present invention permits for lesser skin irritation due to have present is the non-adherent skin contacting layer or a less use of skin contacting adhesives and lesser use of skin coating of a skin non-adherent material that can be placed on permeation enhancers, yet the securement means maintains the otherwise skin adherent material at any time prior to use bandage/skin contact over large areas. Prior art “reservoir So as to assure that the bandage is not skin-adherent. The only type' transdermal devices having adhesive only on the other important portion is the securement means and its periphery of the device, did use lesser amounts of adhesive placement outside of the central portion of the completed than monolithic type devices, but they suffered from the dis device so that the securement means from opposite portions advantage that over large areas, the devices would not main of the device can be brought together in the manner described tain optimal skin contact especially where body movement earlier. Securement means 44a and 44b may span across the would create ripples in the skin. Even further, the larger areas entire width W or only a portion thereof, but preferably that are now potentially able to be covered, would have been extends across the entire width W. In addition, one or both of unacceptable with the skin-contact-adhesive devices of the securement means 44a and 44b need not be completely art simply because removing such devices would be difficult within the dimension L, but may optionally extend from and painful due to the presence of hairs. Even further, in within L to outside of L. Nonetheless, in preferred embodi situations where the transdermal permeability is adequate ments each of layers 41-43, 41a-43a and securement means with a particular drug or formulation, occlusive dressings of 44a and 44b are all present. In a most preferred embodiment, most prior art transdermals becomes less of a concernandone layers 40 and 4.0a are also present. can move to a breathable type of transdermal. The greater area 0065 Skin-non-adherent layers 43 and 43a (when no skin for transdermal administration allows for a less efficient rate non-adherent materials are added post manufacture) are typi of permeation as when non-occlusive dressings are cally comprised of non-adherent polyethylene or polypropy employed. Nonetheless, where desired, one will not depart lene apertured film, with the polyethylene film being from the present invention if one wishes to use the present preferred since the polypropylene material is more rigid. One invention in the context of a transdermal administration using Such non-adherent polyethylene apertured film exemplary of permeation enhancers, skin-contacting adhesives (provided the class is DelStar Delnet(R) polyethylene apertured film Such adhesives are not in contact with skin Surfaces), and/or which is advantageously used in a thickness of about 1 to occlusive materials. about 10 mils thick, preferably about 2 to about 8 mils thick, 0062. In use, the bandages of the present invention are more preferably about 4 to about 6 mils thick. Otherapertured unfolded from one of the pre-use folded positions, and central films of other wound skin non-adherent materials are also portion 8 opened for receiving a body or plant part. If starting possible and will be knownto those of ordinary skill in the art. from the positions shown in FIGS. 6 and 7, pressure is placed In addition, otherwise wound adherent materials may be uti on flaps 6 and 7 centrally. Depending upon the resiliency of lized if they are suitable covered in the wound or skin con the particular materials of which the device 1 is made, such tacting area with an ointment layer Such as those made using central pressure may naturally open sleeve portion 11 or top a petrolatum base. Layers 43 and 43a may be coated with an portion 8 and bottom portion.9 may require some assistance to ointment if desired (and is so if the fabric used is not a wound open into the correct orientation. The body part or plant part non-adherent material), and Such ointment may contain to which the bandage is to be applied is slipped into the sleeve active agents such as without limitation, antiseptics, anti portion and the flaps 6 and 7 are brought together while infectives, topical anesthetics, aids to clotting, and other initially applying a slight amount of pressure on the top por wound healing materials. Alternatively, and especially when tion 9 of central portion 8 near the juncture of flaps 6 and 7 the layers 43 and 43a are inherently wound non-adherent, and with central portion 8 allowing attachment means 12 and 13 therefore no ointment type covering in the skin contact layer to mate and secure the device in place. In a preferred embodi is used, the layers 43 and 43a may be impregnated or have ment, the body part to which the device is applied is an injured layered thereon one or more active agents such as without penis, more preferably a recently circumcised penis, most limitation, antiseptics, anti-infectives, topical anesthetics, preferably a recently circumcised infant penis. aids to clotting, and other wound healing materials. In an 0063. The preferred securement means is Velcro, but any alternative embodiment, layers 43 and 43a may be eliminated securement means will be suitable. The fact that the secure when the layers 42 and 42a are either themselves non-wound ment means is not circumferentially attached about the body adherent or if layers 42 and 42a carry an ointment as part means that in removing the bandage, the securement described above to serve the wound non-adherent function. means can be undone without applying forces to the body or 0.066 Absorbent layers 42 and 42a are typically, but not plant part being treated so as to reduce discomfort to the required to be non-woven polyester pads and are present for US 2009/0005722 A1 Jan. 1, 2009

the purpose of absorption of blood (in the case of human or employed, but the invention includes other manners of con animal wound dressings or of plant wound exudates in the structing the device whether or not such symmetry is present. case of plants wound dressings. One Suitable alternative is (0071. While the securement means 44a and 44b are shown polypropylene, but this is less advantageous because the poly in the figures at the left and right ends of flap portions 6 and 7 ester is the better absorber so that thinner layers could be used and cover the entire width of the flap (as viewed from front to and it is economically more desirable as it is cheaper, has a back), the securement means is not required to traverse the nice bright white color for esthetic purposes, and it sterilizes full width of the flap portion, but preferably does. Thus, a well. One such polyester is DelStar non-woven polyester pad. securement means 44a or 44b may be for example only across The thickness of this layer will vary depending upon the apportion of the width of the flap and may be placed centrally absorption capacity of the exact material chosen and the (as viewed front to back) or off center either closer to the front absorption capacity thereof. Bandages for Small wounds or closer to the back (each as viewed from front to back) where less blood and exudates is anticipated will be able to be provided that the portions 44a and 44b are each placed in the adequately addressed with relatively thinner layers, while same type of arrangement so that the portions 44a and 44b can those for larger wounds or for wounds where larger Volumes mate when the bandage is in use. Additionally, flaps 6 and 7 of blood or exudates are anticipated will be better served with are shown in the figures as being of the same length as viewed thicker layers and more absorbent layers 42 and 42a. Super from central portion 8 towards the portion distal thereto either absorbent materials that may also serve as alternatives for to the right or left. However, central portion 8 need not be at these layers include those absorbent materials utilized in dis the center with two equal sized flaps extending therefrom. An posable diapers, disposable undergarments, and sanitary nap arrangement where one of flaps 6 and 7 extends longer from kins, which are well known in the art. central portion 8 than the other of flaps 6 and 7 is still within 0067 Waterproof layers 41 and 41a, while not absolutely the scope of the present invention, as long as when flaps 6 and required, are highly desirable. This is a thin flexible barrier 7 are brought together, Securement portions 44a and 44b can layer to prevent leakage of blood or exudates out of the mate to effectively secure the bandage in place. Nonetheless, bandage, and when used in the context of an infant circum it is generally preferable to have flaps 6 and 7 extend for equal cision bandage aids in keeping urine from wetting the wound distances from central portion 8. area. A typical exemplary waterproof material is a polyure 0072 For an example of a manufacture of a bandage thane film of about 0.5 to about 4 mils thick, preferably about according to the invention; the following utilizes the embodi 1 to about 2 mils thick. Other waterproof layer materials that ment having soft touch material layers 40 and 40a, water can be suitably used include those used to line disposable prooflayers 41 and 41a, absorbent layers 42 and 42a, wound diapers, disposable undergarments, and sanitary napkins. non-adherent layers 41 and 41a, and Velcro securement Occlusive barrier layers known in the transdermal drug deliv meansportions 44a and 44b. Individual rolls of the soft touch ery art are also suitable and may be used where desired for the material, waterproof material, absorbent pad material, and waterproof layers 41 and 41a if so desired. wound non-adherent material are layered together in 0068 Decorative layers 40 and 4.0a are not required for the sequence and combined into a composite roll using heat seal, functioning of the device of the present invention but are and/or pressure seal, and/or ultrasonic Sealing techniques generally present to provide both an overall aesthetic soft known in the art. Adhesive sealing can also be used alone or touch and to allow for printed matter Such as an aesthetic in conjunction with any of the above but the use of adhesives design, instruction, or branding information. Spun laced fab between the absorbent layer and the wound non-adhesive ric formed by hydroentanglement (used in a wide range of layer would either require the adhesive being present only on products such as hospital gowns, drapes, and bandages) is the periphery or in Some sort of pattern print to permit particularly Suitable. Exemplary commercial materials adequate permeation of fluids to the absorbent layer unless include, without limitation, Dupont Sontara R or Dupont the adhesive is sufficiently permeable not to materially inter Softesse R. Again, outer layer printable soft materials utilized fere with the function of the absorbent layer. Suitable adhe in commercially available disposable diapers, undergar sives and selective adhesive layer printing on a roll of mate ments, and sanitary napkins are Suitable alternatives if rial, as well as adhesives that are compatible with heat desired. sealing, pressure sealing, and/or ultrasonic Sealing techniques 0069. Securement means 44a and 44b are generally are well known in the transdermal art and one of ordinary skill selected from hook and loop materials (usually known as can utilize any such materials and techniques in the manufac Velcro), adhesives, Snaps, and other generally known means ture of the present invention. Nonetheless, because of the of securing two materials together, hook and loop fasteners or selectivity of adhesives and the more expensive manufactur adhesives being preferred, with loop and hook fasteners being ing techniques of selective printing of adhesives, it is prefer most preferred. A highly preferred embodiment has Velcro as able not to use adhesives between the absorbent layer and the the securement means with one of 44a and 44b being the loop wound non-adherent layer. The composites so formed may be portion and the other being the hook portion. (1) cut into appropriate width ribbons, the ribbons combined 0070. In a most preferred embodiment, other than the as below, and then cut into appropriate lengths or (2) the securement means, the completed device is symmetric about composites so formed may be combined as set forth below the centerline in terms of layers present, that is each of layers and then the combined intermediate cut into appropriate 40-43 that are present in the top portion has a corresponding width ribbons, which are then cut into appropriate lengths. layer 40a-43a representing the bottom portion and arranged Either way, the composite (in this example having layers 40. in the same sequence as viewed from the centergoing toward 41, 42, and 43 along with any adhesive that may have been the top and the center going toward the bottom. Nonetheless, used, and having identical layer in reverse order, i.e., 43a, there is no requirement that such symmetry be present for in 42a, 41a, and 40a) are brought together with layer 43 facing all embodiments. In an exemplary manner of constructing the layer 43a. Optional non-adherent ointment (with or without device of the invention, a symmetric embodiment will be active agents) or an active agent Solution may be applied to

US 2009/0005722 A1 Jan. 1, 2009

8. The dressing of claim 8 wherein said wound dressing the skin comprising incorporating said medicament in a further comprises a decorative layer external to said water dressing of claim 1 and applying said dressing to said wound prooflayer. and securing said dressing to said body part without the use of 9. The dressing of claim 1 wherein said securement means an adhesive in contact with the skin. is selected from the group consisting of hook and loop fas 19. A method of transdermally administering a medication teners, adhesives, Snaps, self-adhesive material, and adhe sive. to a body part without the use of an adhesive in contact with 10. The dressing of claim 1 (a) having at least one human the skin comprising incorporating said medication in the medicament incorporated therein or applied thereto prior to dressing of claim 1 and applying said dressing to said body applying said dressing to a human body part; or (b) having at part. least one member selected from human and Veterinary medi 20. A method of avoiding or reducing skin irritation in a caments, and Veterinary pesticidal agents incorporated transdermal product having a transdermally administrable therein or applied thereto prior to applying said dressing to an drug thereinanda skin-adhering adhesive in contact with skin animal body part; or (c) having a at least one material selected in the normal use of said transdermal product comprising from the group consisting of medications, herbicides, herbi incorporating said transdermal product into a dressing of cide Safeners, pesticides, pesticide Safeners, plant growth fac claim 1 Such that a skin-non-adherent layer that permits tors, plant growth retardants, auxins, and mixtures thereof migration of said drug therethough is between said skin incorporated therin or applied thereto prior to applying said adherent adhesive and said skin when said dressing is in use dressing to a plant part. on said body part. 11. The dressing of claim 10 wherein at least one of said 21. A method for reducing or eliminating skin irritation in medicaments is a topical medicament. a transdermal product having a transdermally administrable 12. The dressing of claim 10 wherein at least one of said drug thereinanda skin-adhering adhesive in contact with skin medicaments is a systemically active medicament and said in the normal use of said transdermal product comprising dressing is intended to delivery said systemically active medi omitting the use of said skin-adherent adhesive from said cament to the blood stream. transdermal device to result in a modified transdermal device 13. The dressing of claim 12, wherein said dressing deliv and incorporating said modified transdermal device into the ers said systemically active medicament across intact skin. dressing of claim 1 or utilizing the dressing of claim 1 to 14. The dressing of claim 12, wherein said systemically maintain the modified transdermal device in place on said active medicament is administered transdermally, with or body part. without auxiliary driving energy. 22. A method of reducing or eliminating flux enhancer 15. The dressing of claim 14 further comprising a trans induced skin irritation in a transdermal device while main dermally driving energy generation device, incorporated taining the enhanced flux of a drug contained in said trans therein or attached thereto. dermal device, said transdermal device having at least one 16. The dressing of claim 15 wherein said transdermally flux enhancer therein, comprising reducing, or eliminating driving energy source generation device is an iontophoretic said flux enhancers from said transdermal device and expand device, a sonophoretic device, a photophoretic device, or a ing the size thereof to cover a larger Surface area to result in a pulsed electromagnetic device. modified transdermal device and incorporating said modified 17. The dressing of claim 1 wherein said dressing has a transdermal device into the dressing of claim 1 or utilizing the transdermally administrable drug incorporated therein in a dressing of claim 1 to maintain the modified transdermal liposomal or nanoencapsulation format. device in place on said body part. 18. A method of administering a medicament to an open wound on abody part in the absence of an adhesive contacting c c c c c