DOCSLIB.ORG

PRIVILEGED COMMUNICATION Activation Date October 12, 2015 for INVESTIGATIONAL USE ONLY

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
PRIVILEGED COMMUNICATION Activation Date October 12, 2015 for INVESTIGATIONAL USE ONLY S1505 Page 1 Version Date 9/4/2020 PRIVILEGED COMMUNICATION Activation Date October 12, 2015 FOR INVESTIGATIONAL USE ONLY SWOG TITLE A RANDOMIZED PHASE II STUDY OF PERIOPERATIVE mFOLFIRINOX VERSUS GEMCITABINE/NAB-PACLITAXEL AS THERAPY FOR RESECTABLE PANCREATIC ADENOCARCINOMA NCT #02562716 STUDY CHAIRS: AGENTS: Davendra P.S. Sohal, M.D., M.P.H. (Medical IND-Exempt Agents: Cleveland Clinic Oncology) Fluorouracil (5-FU, Adrucil®) (NSC-19893) 9500 Euclid Ave – R35 Gemcitabine hydrochloride (Gemzar®) Cleveland, OH 44195 (NSC-613327) Phone: 216/444-8258 Irinotecan (Camptosar®) (NSC-616348) FAX: 216/444-9464 nab-Paclitaxel (NSC-736631) E-mail: [email protected] Oxaliplatin (Eloxatin) (NSC-266046) Syed Ahmad, M.D. (Surgery) BIOSTATISTICIANS: University of Cincinnati Medical Center 231 Albert Sabin Way, ML #0558 Katherine A. Guthrie, Ph.D. Cincinnati, OH 45267 Danika Lew, M.S. Phone: 513/558-7866 SWOG Statistical Center FAX: 513/584-0459 Fred Hutchinson Cancer Research Center E-mail: [email protected] 1100 Fairview Avenue N, M3-C102 P.O. Box 19024 Namita Gandhi, M.D. (Radiology) Seattle, WA 98109-1024 Cleveland Clinic Phone: 206/667-4623 9500 Euclid Ave FAX: 206/667-4408 Cleveland, OH 44195 E-mail: [email protected] Phone: 216/444-3682 E-mail [email protected] FAX: 216/636-1699 E-mail: [email protected] Philip A. Philip, M.D., Ph.D., F.R.C.P. Karmanos Cancer Center (Medical Oncology) Wayne State University 4100 John R Street 4HWCRC Detroit, MI 48201 Phone: 313/576-8728 FAX:313/576-8729 E-Mail: [email protected] Andrew M. Lowy, M.D., F.A.C.S. (Surgery) University of California, San Diego Moores Cancer Center 3855 Health Sciences Dr., #0987 La Jolla, CA 92093 Phone: 858/822-2124 FAX: 858/534-4813 E-mail: [email protected] S1505 Page 2 Version Date 9/4/2020 NCTN INVESTIGATORS: Andrea Wang-Gillam M.D., Ph.D. (ALLIANCE) Washington University in St. Louis Phone: 314-362-5740 Fax: 314-362-7086 E-mail: [email protected] M. Shaalan Beg, M.D. (ECOG-ACRIN) UT Southwestern Medical Center Phone: 214/648-4180 FAX: 214/648-1955 E-mail: [email protected] PARTICIPANTS ALLIANCE/Alliance for Clinical Trials in Oncology ECOG-ACRIN/ECOG-ACRIN Cancer Research Group NRG/NRG Oncology SWOG/SWOG S1505 Page 3 Version Date 9/4/2020 TABLE OF CONTENTS TITLE ......................................................................................................................................................... 1 PARTICIPANTS ............................................................................................................................................ 2 TABLE OF CONTENTS ............................................................................................................................... 3 CANCER TRIALS SUPPORT UNIT (CTSU) ADDRESS AND CONTACT INFORMATION ....................... 5 SCHEMA ....................................................................................................................................................... 6 1.0 OBJECTIVES .................................................................................................................................. 7 1.1 Primary Objectives ........................................................................................................................... 7 1.2 Secondary Objectives ...................................................................................................................... 7 1.3 Translational Objectives ................................................................................................................... 7 2.0 BACKGROUND ............................................................................................................................... 7 3.0 DRUG INFORMATION .................................................................................................................... 9 3.1 Fluorouracil (5-FU, Adrucil ®) (NSC-19893) .................................................................................... 9 3.2 Gemcitabine hydrochloride (Gemzar®) (NSC-613327) ................................................................. 11 3.3 Irinotecan (Camptosar®) (NSC-616348) ....................................................................................... 13 3.4 Nab-paclitaxel (Abraxane®) (NSC-736631) ................................................................................... 14 3.5 Oxaliplatin (Eloxatin®) (NSC-266046) ........................................................................................... 18 4.0 STAGING CRITERIA ..................................................................................................................... 20 5.0 ELIGIBILITY CRITERIA ................................................................................................................ 21 5.1 Disease Related Criteria ................................................................................................................ 21 5.2 Prior/Concurrent Therapy Criteria .................................................................................................. 22 5.3 Clinical/Laboratory Criteria ............................................................................................................. 22 5.4 Specimen Submission Criteria ....................................................................................................... 22 5.5 Regulatory Criteria ......................................................................................................................... 23 6.0 STRATIFICATION FACTORS ....................................................................................................... 23 7.0 TREATMENT PLAN ...................................................................................................................... 23 7.1 Pre-Medication and Concomitant Medications and Care .............................................................. 23 7.2 Arm 1: mFOLFIRINOX ................................................................................................................... 24 7.3 Arm 2: Gemcitabine/nab-Paclitaxel ................................................................................................ 24 7.4 Surgery ........................................................................................................................................... 24 7.5 Radiation ........................................................................................................................................ 27 7.6 Criteria for Removal from Protocol Treatment ............................................................................... 27 7.7 Discontinuation of Treatment ......................................................................................................... 27 7.8 Follow-Up Period ............................................................................................................................ 27 8.0 TOXICITIES TO BE MONITORED AND DOSE MODIFICATIONS .............................................. 28 8.1 NCI Common Terminology Criteria for Adverse Events ................................................................ 28 8.2 General Considerations ................................................................................................................. 28 8.3 Dose Modifications for Arm 1: mFOLFIRINOX .............................................................................. 28 8.4 Dose Modifications for Arm 2: Gemcitabine/nab-Paclitaxel ........................................................... 31 8.5 Dose Modification Contacts ........................................................................................................... 32 8.6 Adverse Event Reporting ............................................................................................................... 33 9.0 STUDY CALENDAR ...................................................................................................................... 34 9.1 Arm 1: mFOLFIRINOX ................................................................................................................... 34 10.0 CRITERIA FOR EVALUATION AND ENDPOINT ANALYSIS ..................................................... 37 10.1 Measurability of Lesions................................................................................................................. 37 10.2 The definitions for the resection classification that should be utilized in operative notes include: 38 10.3 Objective Status at Each Disease Evaluation ................................................................................ 38 10.4 Best Response ............................................................................................................................... 40 10.5 Performance Status ....................................................................................................................... 40 10.6 Pathologic Response ..................................................................................................................... 41 10.7 Loco-regional recurrence ............................................................................................................... 41 10.8 Distant recurrence .......................................................................................................................... 41 10.9 Disease-Free Survival (DFS) ......................................................................................................... 41 10.10 Time to Death ................................................................................................................................
Load more

Recommended publications
  • Scuba Diving History
    Scuba diving history Scuba history from a diving bell developed by Guglielmo de Loreno in 1535 up to John Bennett’s dive in the Philippines to amazing 308 meter in 2001 and much more… Humans have been diving since man was required to collect food from the sea. The need for air and protection under water was obvious. Let us find out how mankind conquered the sea in the quest to discover the beauty of the under water world. 1535 – A diving bell was developed by Guglielmo de Loreno. 1650 – Guericke developed the first air pump. 1667 – Robert Boyle observes the decompression sickness or “the bends”. After decompression of a snake he noticed gas bubbles in the eyes of a snake. 1691 – Another diving bell a weighted barrels, connected with an air pipe to the surface, was patented by Edmund Halley. 1715 – John Lethbridge built an underwater cylinder that was supplied via an air pipe from the surface with compressed air. To prevent the water from entering the cylinder, greased leather connections were integrated at the cylinder for the operators arms. 1776 – The first submarine was used for a military attack. 1826 – Charles Anthony and John Deane patented a helmet for fire fighters. This helmet was used for diving too. This first version was not fitted to the diving suit. The helmet was attached to the body of the diver with straps and air was supplied from the surfa 1837 – Augustus Siebe sealed the diving helmet of the Deane brothers’ to a watertight diving suit and became the standard for many dive expeditions.
    [Show full text]
  • History of Scuba Diving About 500 BC: (Informa on Originally From
    History of Scuba Diving nature", that would have taken advantage of this technique to sink ships and even commit murders. Some drawings, however, showed different kinds of snorkels and an air tank (to be carried on the breast) that presumably should have no external connecons. Other drawings showed a complete immersion kit, with a plunger suit which included a sort of About 500 BC: (Informaon originally from mask with a box for air. The project was so Herodotus): During a naval campaign the detailed that it included a urine collector, too. Greek Scyllis was taken aboard ship as prisoner by the Persian King Xerxes I. When Scyllis learned that Xerxes was to aack a Greek flolla, he seized a knife and jumped overboard. The Persians could not find him in the water and presumed he had drowned. Scyllis surfaced at night and made his way among all the ships in Xerxes's fleet, cung each ship loose from its moorings; he used a hollow reed as snorkel to remain unobserved. Then he swam nine miles (15 kilometers) to rejoin the Greeks off Cape Artemisium. 15th century: Leonardo da Vinci made the first known menon of air tanks in Italy: he 1772: Sieur Freminet tried to build a scuba wrote in his Atlanc Codex (Biblioteca device out of a barrel, but died from lack of Ambrosiana, Milan) that systems were used oxygen aer 20 minutes, as he merely at that me to arficially breathe under recycled the exhaled air untreated. water, but he did not explain them in detail due to what he described as "bad human 1776: David Brushnell invented the Turtle, first submarine to aack another ship.
    [Show full text]
  • Sexually Transmitted Diseases Treatment Guidelines, 2015
    Morbidity and Mortality Weekly Report Recommendations and Reports / Vol. 64 / No. 3 June 5, 2015 Sexually Transmitted Diseases Treatment Guidelines, 2015 U.S. Department of Health and Human Services Centers for Disease Control and Prevention Recommendations and Reports CONTENTS CONTENTS (Continued) Introduction ............................................................................................................1 Gonococcal Infections ...................................................................................... 60 Methods ....................................................................................................................1 Diseases Characterized by Vaginal Discharge .......................................... 69 Clinical Prevention Guidance ............................................................................2 Bacterial Vaginosis .......................................................................................... 69 Special Populations ..............................................................................................9 Trichomoniasis ................................................................................................. 72 Emerging Issues .................................................................................................. 17 Vulvovaginal Candidiasis ............................................................................. 75 Hepatitis C ......................................................................................................... 17 Pelvic Inflammatory
    [Show full text]
  • Rostocker Meeresbiologische Beiträge
    Rostocker Meeresbiologische Beiträge Beiträge Zum Rostocker Forschungstauchersymposium 2019 Heft 30 Universität Rostock Institut für Biowissenschaften 2020 HERAUSGEBER DIESES HEFTES: Hendrik Schubert REDAKTION: Dirk Schories Gerd Niedzwiedz Hendrik Schubert HERSTELLUNG DER DRUCKVORLAGE: Christian Porsche CIP-KURZTITELAUFNAHME Rostocker Meeresbiologische Beiträge. Universität Rostock, Institut für Biowissenschaften. – Rostock, 2020. – 136 S. (Rostocker Meeresbiologische Beiträge; 30) ISSN 0943-822X © Universität Rostock, Institut für Biowissenschaften, 18051 Rostock REDAKTIONSADRESSE: Universität Rostock Institut für Biowissenschaften 18051 Rostock e-mail: [email protected] Tel. 0381 / 498-6071 Fax. 0381 / 498-6072 BEZUGSMÖGLICHKEITEN: Universität Rostock Universitätsbibliothek, Schriftentausch 18051 Rostock e-mail: [email protected] DRUCK: Druckerei Kühne & Partner GmbH & Co KG Umschlagfoto Titel: Unterwasseraufnahmen und Abbildung des Riffs in Nienhagen, [Uwe Friedrich, style-kueste.de] Rückseite: Gruppenbild der Forschungstauchertagung [Thomas Rahr, Universität Rostock, ITMZ] 2 Inhalt Seite FISCHER, P. 5 Vorwort NIEDZWIEDZ, G. 7 25 Jahre Forschungstaucherausbildung in Rostock – eine Geschichte mit langer Vorgeschichte VAN LAAK, U. 39 Der Tauchunfall als misslungene Prävention: Ergebnisse aus der DAN Europe Feldforschung MOHR, T. 51 Überblick zum Forschungsprojekt „Riffe in der Ostsee“ NIEDZWIEDZ, G. & SCHORIES, D. 65 Georeferenzierung von Unterwasserdaten: Iststand und Perspektiven SCHORIES, D. 81 Ein kurzer Ausschnitt über wissenschaftliches Fotografieren Unter- wasser und deren Anwendung WEIGELT, R., HENNICKE, J. & VON NORDHEIM, H. 93 Ein Blick zurück, zwei nach vorne – Forschungstauchen am Bundes- amt für Naturschutz zum Schutz der Meere AUGUSTIN, C. B., BÜHLER, A. & SCHUBERT, H. 103 Comparison of different methods for determination of seagrass distribution in the Southern Baltic Sea Coast SCHORIES, D., DÍAZ, M.-J., GARRIDO, I., HERAN, T., HOLTHEUER, J., KAPPES, J. 117 J., KOHLBERG, G.
    [Show full text]
  • 2 Accidents De Décompression D'origine Médullaire En
    AIX-MARSEILLE UNIVERSITE Président : Yvon BERLAND FACULTE DES SCIENCES MEDICALES ET PARAMEDICALES Administrateur provisoire: Georges LEONETTI Affaires Générales : Patrick DESSI Professions Paramédicales : Philippe BERBIS Assesseurs : aux Etudes : Jean-Michel VITON à la Recherche : Jean-Louis MEGE aux Prospectives Hospitalo-Universitaires : Frédéric COLLART aux Enseignements Hospitaliers : Patrick VILLANI à l’Unité Mixte de Formation Continue en Santé : Fabrice BARLESI pour le Secteur Nord : Stéphane BERDAH aux centres hospitaliers non universitaires : Jean-Noël ARGENSON Chargés de mission : 1er cycle : Jean-Marc DURAND et Marc BARTHET 2ème cycle : Marie-Aleth RICHARD 3eme cycle DES/DESC : Pierre-Edouard FOURNIER Licences-Masters-Doctorat : Pascal ADALIAN DU-DIU : Véronique VITTON Stages Hospitaliers : Franck THUNY Sciences Humaines et Sociales : Pierre LE COZ Préparation à l’ECN : Aurélie DAUMAS Démographie Médicale et Filiarisation : Roland SAMBUC Relations Internationales : Philippe PAROLA Etudiants : Arthur ESQUER Chef des services généraux : Déborah ROCCHICCIOLI Chefs de service : Communication : Laetitia DELOUIS Examens : Caroline MOUTTET Intérieur : Joëlle FAVREGA Maintenance : Philippe KOCK Scolarité : Christine GAUTHIER DOYENS HONORAIRES M. Yvon BERLAND M. André ALI CHERIF M. Jean-François PELLISSIER Mis à jour 01/01/2019 PROFESSEURS HONORAIRES MM AGOSTINI Serge MM FAVRE Roger ALDIGHIERI René FIECHI Marius ALESSANDRINI Pierre FARNARIER Georges ALLIEZ Bernard FIGARELLA Jacques AQUARON Robert FONTES Michel
    [Show full text]
  • Pacific Northwest Diver BI-MONTHLY MAGAZINE & WEB SITE PROMOTING UNDERWATER PHOTOGRAPHY, EDUCATION, & TRAVEL in the PACIFIC NORTHWEST | JANUARY, 2012
    PPacificUBLICATION OF THE PACIFIC Northwest NORTHWEST UNDERWATER PHOTOGRA DiverPHIC SOCIETY BRITISH COLUMBIA | WASHINGTON | OREGON | JANUARY, 2012 Page 1 Gunnel Condo | Janna Nichols Pacific Northwest Diver BI-MONTHLY MAGAZINE & WEB SITE PROMOTING UNDERWATER PHOTOGRAPHY, EDUCATION, & TRAVEL IN THE PACIFIC NORTHWEST | JANUARY, 2012 In this Issue 3 Nanaimo to Corvallis 3 Subscribing to Pacific Northwest Diver 3 From the Archives: First Underwater Photo, 1893 3 Featured Photographer: Janna Nichols 4 News Corner 7 REEF 7 Andy Lamb Joins PNW Diver Team 7 Underwater Photo Workshops 7 Call for Critter Photos 8 Nudibranch ID App 8 Congrats to Pat Gunderson & Laurynn Evans 8 Feartured Operator/Resort: Sea Dragon Charters 9 Photographers & Videographers 11 British Columbia: John Melendez 11 Washington: Mike Meagher 13 Oregon: Aaron Gifford 15 Dive Travel Corner 17 Grand Bahama Island: Dolphins, Sharks, & Cavern 17 La Paz: Whale Sharks, Sea Lions, & Hammerheads 17 Technical Corner 18 Subsee Super Macro 18 PNW Diver Team 20 iPhone Users: Your PDF viewer does not support active links. To view video and use other links, we suggest the ap Goodreader <http://www.goodiware.com/goodreader.html>. Page 2 Pacific Northwest Diver: In This Issue Welcome to the January issue of Pacific Northwest Diver! This issue’s featured photographer is Janna Nichols. Janna is well know to the dive community, as she is the outreach coordinator for REEF. Not only is she an outstanding creature ID”er”, she is an excellent photographer. Our featured operator is Sea Dragon Charters in Howe Sound and Nanaimo, and we will be checking out photos from John Melendez in Vancouver, BC, Mike Meagher in Bellingham (be sure to watch the newly hatched wolf eel swimming in front of dad), and Aaron Giffords from Corvallis diving off of Newport, Oregon.
    [Show full text]
  • An Updated Short History of the British Diving Apparatus Manufacturers
    18 The International Journal of Diving History The International Journal of Diving History 19 Fig. 1. Some key persons from the firm of Siebe Gorman. 1a. (Christian) Augustus Siebe An Updated Short History of the British Diving Apparatus (1788-1872). Company founder. Manufacturers, Siebe Gorman and Heinke 1b. William Augustus Gorman (formerly O’Gorman; 1834-1904). by Michael Burchett, HDS, and Robert Burchett, HDS. Joint partner with Henry H. Siebe (1830-1885) at Siebe & Gorman (later Siebe Gorman & Co.). PART 1. THE SIEBE GORMAN COMPANY 1c. Sir Robert Henry Davis Introduction 1a. 1b. 1c. (1870-1965). Managing Director This account endeavours to produce a short, updated history of the Siebe Gorman and Heinke of Siebe Gorman & Co. manufacturing companies using past and present sources of literature. It does not attempt to include every aspect of the two company histories, but concentrates on key events with an emphasis on 1d. Henry Albert Fleuss the manufacture of diving apparatus. However, an understanding of their histories is not complete (1851-1933). Designer of the first without some knowledge of the social history and values of the period. Victorian and Edwardian practical ‘self-contained breathing society engendered moral values such as hard work, thrift, obedience and loyalty within a class-ridden apparatus’. system, in which poverty, harsh working conditions and basic education were normal for the working 1e. Professor John Scott Haldane classes. With intelligence and application, people could ‘better themselves’ and gain respect in an age of (1860-1936). Diving physiologist innovation, when Britain led the industrial world. who produced the first naval The businesses of Augustus Siebe and ‘Siebe, Gorman’ (in one form or another) survived for over 170 ‘Decompression Dive Tables’.
    [Show full text]
  • Klaipėda University
    KLAIPĖDA UNIVERSITY ALEKSEJ ŠAŠKOV APPLICATION OF UNDERWATER REMOTE IMAGERY AND ACOUSTIC DATA FOR QUANTITATIVE BENTHIC BIOTOPES IDENTIFICATION, PREDICTIVE MAPPING AND BUILDING OF EXPLANATORY MODELS Doctoral dissertation Biomedical sciences, ecology and environmental sciences (03B) Klaipėda, 2014 Dissertation prepared in 2009–2014 in Klaipėda University. Supervisor: prof. habil. dr. Sergej Olenin (Klaipėda University; Biomedical Sciences, Ecology and Environmental Sciences – 03B). The dissertation will be defended at the Research Board for ecology and environmental sciences: Chairman: prof. dr. Albertas Bitinas (Klaipėda University, physical science, geology, 05P). Members: dr. Anastasija Zaiko (Klaipėda University, biomedical sciences, ecology and environmental sciences, 03B); dr. Juris Aigars (Latvian Water Ecology Institute, biomedical sciences, ecology and environmental sciences, 03B); dr. Ali Ertürk (Stambul University, biomedical sciences, ecology and environmental sciences, 03B); prof. dr. Vitalij Denisov (Klaipėda University, technological science, informatics ingineering, 07T). Opponents: habil. dr. Maria Włodarska-Kowalczuk (Oceanology Institute of Poland Academy of Science, biomedical sciences, Ecology and environmental Sciences, 03B); dr. Linas Ložys (Nature Research Centre, biomedical sciences, ecology and environmental sciences, 03B). The defence of dissertation will take place on 26th of November 2014, at 2 p.m., at the Klaipėda University Aula Magna Conference room. Address: Herkaus Manto 84, LT-92294, Klaipėda, Lithuania
    [Show full text]
  • Subsea Imaging and Sensing
    Subsea Imaging and Sensing Prof John Watson University of Aberdeen Subsea Optics & Sensing Long and varied pedigree - back to ancient Greeks and Romans Optical imaging, vision and sensing plays a crucial role in our understanding and exploitation of our aquatic environment. From coastline to deepwater and from lakes to rivers many challenges face us in our drive to understand, utilise and preserve this unique habitat. New techniques and instruments are continually being developed to enable us to probe and monitor its behaviour To optimise the oceans as a sustainable resource of minerals & food Invention of the laser & parallel developments of electronic detectors and high-performance computers projected optics to the fore as a cornerstone of subsea exploration Optics & Photonics Of increasing importance amongst these techniques is the use of optics and photonics technology in imaging, vision and sensing. Imaging and visualisation using conventional photography and video Advanced techniques like digital holography, range-gated imaging or laser line scanners are crucial tools in subsea operations and offer a new perspective for monitoring aquatic life, mapping the seafloor or mensuration of natural and man-made structures. In the wider context, high-resolution monitoring and rapid assessment of the environment relies on the application of optical sensors, often in parallel with acoustical and physical/electronic probes. Optical Sensors Integrated onto autonomously or remotely controlled observation platforms or global observation networks. conventional 2D to 3D imaging; studies of optical properties to propagation of light in water; sensing of ocean colour to seafloor mapping monitoring of plankton/fish populations studies, hyperspectral sensing for understanding of light and its interaction with biogeochemical water constituents.
    [Show full text]
  • Milica Stojanovic Telecommunications Engineering, 2011
    TOWARDS U NDERWATER V IDEO T RANSMISSION Master of Science Thesis Author: Laura Dubreuil Vall Advisor: Milica Stojanovic Telecommunications Engineering, 2011 Per Aspera Ad Astra (Through adversity to the stars. Latin proverb) Laura Dubreuil Vall 5 Contents 1 Introduction 21 1.1 Motivation . 21 1.2 Historical background . 22 1.3 Goals . 22 1.4 Outline . 23 2 Image and video compression 25 2.1 Compression fundamentals . 25 2.1.1 Lossless and lossy compression methods . 26 2.1.2 Entropy, source and hybrid video coding . 26 2.2 The MPEG-4 standard . 27 2.2.1 General description . 27 2.2.2 MPEG-4 object-oriented hierarchy . 27 2.2.3 Coder type and profile . 29 2.3 A special case of compression: Video Compressed Sensing . 30 2.3.1 Compressed Sensing fundamentals . 30 2.3.2 Compressed Sensing applied to video compression . 31 2.3.3 Video Compressed Sensing versus MPEG-4 . 31 2.3.4 Applications of Video Compressed Sensing . 32 3 Communication link 35 3.1 Existing techniques for underwater wireless transmission . 35 3.1.1 Radio Frequency waves . 35 3.1.2 Optical waves . 35 3.1.3 Acoustic waves . 35 3.2 Underwater channel . 36 3.2.1 Acoustic propagation . 36 3.2.1.1 Attenuation . 36 3.2.1.2 Noise . 37 3.2.1.3 Propagation delay . 37 3.2.1.4 Multipath propagation . 38 3.2.1.5 Doppler effect . 38 3.2.2 Resource allocation . 39 3.2.2.1 The AN product and the SNR . 39 3.2.2.2 Optimal frequency .
    [Show full text]
  • Animals and the Shaping of Modern Medicine
    medicine and biomedical sciences in modern history sciences in modern and biomedical medicine ANIMALS AND THE SHAPING OF MODERN MEDICINE ONE HEALTH AND ITS HISTORIES ABIGAIL WOODS, MICHAEL BRESALIER, ANGELA CASSIDY, RACHEL MASON DENTINGER Medicine and Biomedical Sciences in Modern History Series Editors Carsten Timmermann University of Manchester Manchester United Kingdom Michael Worboys University of Manchester Manchester United Kingdom The aim of this series is to illuminate the development and impact of medicine and the biomedical sciences in the modern era. The series was founded by the late Professor John Pickstone, and its ambitions refect his commitment to the integrated study of medicine, science and tech- nology in their contexts. He repeatedly commented that it was a pity that the foundation discipline of the feld, for which he popularized the acronym ‘HSTM’ (History of Science, Technology and Medicine) had been the history of science rather than the history of medicine. His point was that historians of science had too often focused just on scientifc ideas and institutions, while historians of medicine always had to con- sider the understanding, management and meanings of diseases in their socio-economic, cultural, technological and political contexts. In the event, most of the books in the series dealt with medicine and the bio- medical sciences, and the changed series title refects this. However, as the new editors we share Professor Pickstone’s enthusiasm for the inte- grated study of medicine, science and technology, encouraging studies on biomedical science, translational medicine, clinical practice, disease histories, medical technologies, medical specialisms and health policies. The books in this series will present medicine and biomedical science as crucial features of modern culture, analysing their economic, social and political aspects, while not neglecting their expert content and con- text.
    [Show full text]
  • Louis Boutan Et La Photographie Sous-Marine (1886 -1900) Rahmy Elkays
    Louis Boutan et la photographie sous-marine (1886 -1900) Rahmy Elkays To cite this version: Rahmy Elkays. Louis Boutan et la photographie sous-marine (1886 -1900). 2019. halshs-02165833 HAL Id: halshs-02165833 https://halshs.archives-ouvertes.fr/halshs-02165833 Preprint submitted on 26 Jun 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Louis Boutan et la photographie sous-marine (1886 – 1900) ‘Il en est du naturaliste comme du chasseur ; ce n’est pas dans un tiré que l’on parvient à trouver du gibier. Celui qui est guidé par une longue expérience, durement acquise, trouvera toujours quelque chose là où tout autre ne verra rien’ Henri de Lacaze-Duthiers, Archives de Zoologie Expérimentale et Générale (1891) Introduction : L’invention de la photographie constitue l’un des grands moments de la transformation esthétique et technologique du 19ème siècle. Son emploi dans la recherche scientifique, et tout particulièrement dans les sciences naturelles reste cependant conditionné, pendant toute la période, aux possibilités qu’elle pourrait offrir pour l’observation de processus, de matières ou d’êtres vivants. A mesure que le siècle avance, il devient évident pour nombre de savants que l’emploi des dispositifs de prise de vues automatiques nécessite la mise au point d’équipements particuliers, développés pour des applications spécifiques.
    [Show full text]