EBP1/PA2G4 Rabbit Pab

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Leader in Biomolecular Solutions for Life Science EBP1/PA2G4 Rabbit pAb Catalog No.: A5376 Basic Information Background Catalog No. This gene encodes an RNA-binding protein that is involved in growth regulation. This A5376 protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA Observed MW processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor 44kDa and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle Calculated MW regulatory genes through its interactions with histone deacetylases. This protein has 38kDa/43kDa been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been Category identified. Primary antibody Applications WB, IHC Cross-Reactivity Human, Mouse, Rat Recommended Dilutions Immunogen Information WB 1:500 - 1:2000 Gene ID Swiss Prot 5036 Q9UQ80 IHC 1:50 - 1:200 Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-394 of human EBP1/PA2G4 (NP_006182.2). Synonyms PA2G4;EBP1;HG4-1;p38-2G4 Contact Product Information www.abclonal.com Source Isotype Purification Rabbit IgG Affinity purification Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using EBP1/PA2G4 antibody (A5376) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Immunohistochemistry of paraffin- Immunohistochemistry of paraffin- Immunohistochemistry of paraffin- embedded rat lung using EBP1/PA2G4 embedded human liver cancer using embedded human esophagus using Antibody (A5376) at dilution of 1:100 (40x EBP1/PA2G4 Antibody (A5376) at dilution EBP1/PA2G4 Antibody (A5376) at dilution lens). of 1:100 (40x lens). of 1:100 (40x lens). Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

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Genome-Wide Analysis of Androgen Receptor Binding and Gene Regulation in Two CWR22-Derived Prostate Cancer Cell Lines
Endocrine-Related Cancer (2010) 17 857–873 Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines Honglin Chen1, Stephen J Libertini1,4, Michael George1, Satya Dandekar1, Clifford G Tepper 2, Bushra Al-Bataina1, Hsing-Jien Kung2,3, Paramita M Ghosh2,3 and Maria Mudryj1,4 1Department of Medical Microbiology and Immunology, University of California Davis, 3147 Tupper Hall, Davis, California 95616, USA 2Division of Basic Sciences, Department of Biochemistry and Molecular Medicine, Cancer Center and 3Department of Urology, University of California Davis, Sacramento, California 95817, USA 4Veterans Affairs Northern California Health Care System, Mather, California 95655, USA (Correspondence should be addressed to M Mudryj at Department of Medical Microbiology and Immunology, University of California, Davis; Email: [email protected]) Abstract Prostate carcinoma (CaP) is a heterogeneous multifocal disease where gene expression and regulation are altered not only with disease progression but also between metastatic lesions. The androgen receptor (AR) regulates the growth of metastatic CaPs; however, sensitivity to androgen ablation is short lived, yielding to emergence of castrate-resistant CaP (CRCaP). CRCaP prostate cancers continue to express the AR, a pivotal prostate regulator, but it is not known whether the AR targets similar or different genes in different castrate-resistant cells. In this study, we investigated AR binding and AR-dependent transcription in two related castrate-resistant cell lines derived from androgen-dependent CWR22-relapsed tumors: CWR22Rv1 (Rv1) and CWR-R1 (R1). Expression microarray analysis revealed that R1 and Rv1 cells had signiﬁcantly different gene expression proﬁles individually and in response to androgen.
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PA2G4 Antibody (F54781)
PA2G4 Antibody / EBP1 / ErbB3-binding protein 1 (F54781) Catalog No. Formulation Size F54781-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml F54781-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml Bulk quote request Availability 1-3 business days Species Reactivity Human Format Purified Clonality Polyclonal (rabbit origin) Isotype Rabbit Ig Purity Purified UniProt Q9UQ80 Localization Cytoplasmic, nuclear Applications Immunofluorescence : 1:25 Flow cytometry : 1:25 (1x10e6 cells) Immunohistochemistry (FFPE) : 1:25 Western blot : 1:500-1:1000 Limitations This PA2G4 antibody is available for research use only. IHC testing of FFPE human lung carcinoma tissue with PA2G4 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining. Immunofluorescent staining of fixed and permeabilized human U-251 cells with PA2G4 antibody (green), DAPI nuclear stain (blue) and anti-Actin (red). Western blot testing of human 1) A431 and 2) Jurkat cell lysate with PA2G4 antibody. Predicted molecular weight ~44 kDa. Flow cytometry testing of human A2058 cells with PA2G4 antibody; Blue=isotype control, Green= PA2G4 antibody. Description PA2G4 is an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. The protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. It is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases.
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A Dissertation Entitled the Androgen Receptor
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Open Data for Differential Network Analysis in Glioma
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PA2G4 Antibody (Center R243) Blocking Peptide Synthetic Peptide Catalog # Bp2848d
10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 PA2G4 Antibody (Center R243) Blocking Peptide Synthetic peptide Catalog # BP2848d Specification PA2G4 Antibody (Center R243) Blocking PA2G4 Antibody (Center R243) Blocking Peptide - Peptide - Background Product Information PA2G4 is an RNA-binding protein that is Primary Accession Q9UQ80 involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome PA2G4 Antibody (Center R243) Blocking Peptide - Additional Information assembly and the regulation of intermediate and late steps of rRNA processing. The protein can interact with the cytoplasmic domain of Gene ID 5036 the ErbB3 receptor and may contribute to transducing growth regulatory signals. It is also Other Names a transcriptional co-repressor of androgen Proliferation-associated protein 2G4, Cell receptor-regulated genes and other cell cycle cycle protein p38-2G4 homolog, hG4-1, regulatory genes through its interactions with ErbB3-binding protein 1, PA2G4, EBP1 histone deacetylases. It has been implicated in Target/Specificity growth inhibition and the induction of The synthetic peptide sequence used to differentiation of human cancer cells. generate the antibody <a href=/products/AP2848d>AP2848d</a> PA2G4 Antibody (Center R243) Blocking was selected from the Center region of Peptide - References human PA2G4. A 10 to 100 fold molar excess to antibody is recommended. Zhang,Y., Mol. Cancer Ther. 7 (10), 3176-3186 Precise conditions should be optimized for a (2008)Zhang,Y., Cancer Lett. 265 (2), 298-306 particular assay. (2008)Okada,M., J. Biol. Chem. 282 (50), 36744-36754 (2007) Format Peptides are lyophilized in a solid powder format.
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Renoprotective Effect of Combined Inhibition of Angiotensin-Converting Enzyme and Histone Deacetylase
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EBP1 (PA2G4) Mouse Monoclonal Antibody [Clone ID: OTI1D3] Product Data
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