RESEARCH ARTICLE Efficacy of fluoride varnishes for preventing enamel demineralization after interproximal enamel reduction. Qualitative and quantitative evaluation Ascensio n Vicente1☯*, Antonio Jose Ortiz Ruiz2☯, BeleÂn Manuela GonzaÂlez Paz1³, Jose GarcõÂa Lo pez1³, Luis-Alberto Bravo-GonzaÂlez1☯ 1 Department of Orthodontics, Faculty of Medicine, University of Murcia, Hospital Morales Meseguer, 2ã planta, C/ MarqueÂs de los VeÂlez s/n, Murcia, Spain, 2 Department of Integral Pediatric Dentistry, Faculty of Medicine, University of Murcia, Hospital Morales Meseguer, 2ã planta, C/ MarqueÂs de los VeÂlez s/n, Murcia, Spain a1111111111 a1111111111 ☯ These authors contributed equally to this work. a1111111111 ³ These authors also contributed equally to this work. *
[email protected] a1111111111 a1111111111 Abstract OPEN ACCESS Citation: Vicente A, Ortiz Ruiz AJ, GonzaÂlez Paz Objectives BM, GarcõÂa LoÂpez J, Bravo-GonzaÂlez L-A (2017) To evaluate quantitatively and qualitatively the changes produced to enamel after interproxi- Efficacy of fluoride varnishes for preventing enamel mal reduction and subjected to demineralization cycles, after applying a fluoride varnish demineralization after interproximal enamel reduction. Qualitative and quantitative evaluation. (Profluorid) and a fluoride varnish containing tricalcium phosphate modified by fumaric acid PLoS ONE 12(4): e0176389. https://doi.org/ (Clinpro White). 10.1371/journal.pone.0176389 Editor: Giuseppe Remuzzi, Istituto Di Ricerche Farmacologiche Mario Negri, ITALY Materials and methods Received: October 6, 2016 138 interproximal dental surfaces were divided into six groups: 1) Intact enamel; 2) Intact Accepted: April 10, 2017 enamel + demineralization cycles (DC); 3) Interproximal Reduction (IR); 4) IR + DC; 5) IR + Published: April 21, 2017 Profluorid + DC; 6) IR + Clinpro White + DC. IR was performed with a 0.5 mm cylindrical dia- mond bur.