Medicinal Plants for the Treatment of Mūtrakṛcchra in the Bṛhattrayī And

Total Page:16

File Type:pdf, Size:1020Kb

Medicinal Plants for the Treatment of Mūtrakṛcchra in the Bṛhattrayī And International Journal of Herbal Medicine 2016; 4(4): 01-08 E-ISSN: 2321-2187 P-ISSN: 2394-0514 IJHM 2016; 4(4): 01-08 Medicinal plants for the treatment of Mūtrakṛcchra in Received: 01-05-2016 Accepted: 02-06-2016 the Bṛhattrayī and Mādhava Cikitsā treatises of Āyurveda AK Thorat Biotechnology Research Centre, Department of Biotechnology, AK Thorat and DN Mishra College of Computer Science and IT, Ambajogai Road, Latur, Maharashtra, India. Abstract Mādhava is one of the Āyurvedic practitioners (ca 9th Century CE) after the Caraka – Suśruta era, who DN Mishra had made a great compilation called Mādhava Nidāna. In a later stage, another unique treatise was Sub-Centre (Swami Ramanand composed by the same author Mādhava, named Mādhava Cikitsā in the line of diseases referred to in Teerth Marathwada University), Mādhava Nidāna. Mādhava Cikitsā composition is not well known to the world due to the absence of a Ausa Road, Peth, Latur, proper critical edition on the basis of available manuscripts. A study of the medicinal plants used for the Maharashtra, India. treatment of Mūtrakṛcchra disease (painful urination) given in Mādhava Cikitsā was compared to that of the Bṛhattrayī (Caraka Saṁhitā, Suśruta Saṁhitā and Aṣṭāṅgahṛdayam) texts. It is found in the study that a single Sanskrit name of a plant has also been described for other plant species having different botanical identity in the literature. The ambiguity in plant names and botanical identity has been assigned to non-availability of suitable ancient taxonomic or pharmacognostic records for the correct botanical identifications of the Sanskrit as well as the vernacular names of medicinal plants of the same period. An attempt is made here to find the most probable correct botanical identification of each plant described for Mūtrakṛcchra Cikitsā in the texts, through a critical survey of the literature and by analysing and comparing all possible identifications. The study of the texts and matching of the medicinal plant names made the list to contain 38 identified plant species for the treatment of Mūtrakṛcchra as common in these four treatises of Āyurveda. There are 09 different plants identified in the description of Mādhava Cikitsā only which are not mentioned in the Bṛhattrayī. However, a majority of the plant species (43%) belong to herbaceous habit and to family Poaceae, Zingiberacea (4-4 plants each) followed by family Apiaceae, Fabaceae, Solanaceae (2-2 Plants each) and one-one plants are represented by family Cucurbitaceae, Cyperaceae, Marsileaceae, Musaceae, Saxifragaceae, Zygophyllaceae. The present discussion of the taxonomically most appropriate plant names contributes to the relevant domain of knowledge about these medicinal plants and their variations, which turn contributes to the exploration of their curative and therapeutic value in Mūtrakṛcchra Cikitsā. Keywords: Āyurveda, Medicinal plants, Bṛhattrayī, Mādhava Cikitsā, Mūtrakṛcchra. 1. Introduction India has a rich intellectual and textual heritage that dates back to several hundreds of years. India is also being distinguished for its largest collections of manuscripts of any civilization in the world. There are more than five million manuscripts collected, which consist of several valuable medical texts [1]. Āyurveda, the Indian indigenous system of medicine, dating back to the Vedic period (ca 4500-1600 BC) has been an integral part of Indian culture [2]. Plants have been used as a rich source of effective and safe medicines due to their natural healing [3-6] properties . According to WHO estimate, about 80% of the world populations depend on [3, 4, 5, 7] traditional medicines, mostly on plant drugs to treat various ailments . Three major Sanskrit texts on Āyurveda viz. Caraka Samhitā, Suśrut Samhitā and Aṣṭāṅgahṛdayam were written by the ancient Āyurvedic practitioner’s Ācārya Caraka, Ācārya Suśruta and Ācārya Vagbhatta respectively and these three Āyurvedic treatises are collectively [8, 9] known as Bṛhattrayī . Suśruta and Caraka are regarded as the oldest medicinal authorities [10] and are held in great esteem in India till today . Mādhava is one of the Āyurvedic Correspondence practitioners of the middle age (ca 9th century CE), who also contributed immensely to AK Thorat Āyurvedic work. He had written (perhaps) about 11 Sanskrit texts on Āyurveda. The most Biotechnology Research Centre, famous volumes out of these are Mādhava Nidāna and Mādhava Cikitsā [9]. Department of Biotechnology, College of Computer Science and Mūtrakṛcchra is the condition of painful urination or incontinence of urine. In modern [12-15] IT, Ambajogai road, Latur, terminology, it is called as Dysuria . In the classical Āyurvedic Sanskrit texts, urinary tract Maharashtra, India. disorder is described as Mūtrakṛcchra [2]. Bṛhattrayī and Mādhava Cikitsā texts have given the ~ 1 ~ International Journal of Herbal Medicine treatment of Mūtrakṛcchra and described many herbal plant 2. Methodology of the study preparations to cure this disorder. But rapid modernization, The text of the Mādhav Cikitsā, Ācārya-Mādhavakar-viracita, urbanization, deforestation and extinction of many plant was studied from its only edition in Sanskrit with Hindi species resulted in adulteration and substitution of incorrect commentary edited by Vaidya Sohanlal Dhadhica and raw drugs in the alternative healthcare approaches [16, 17]. At Principal Shri Bhanvarlal Dugad. So also the texts of present, the adulteration and substitution of the herbal drugs Bṛhattrayī (Caraka Samhitā, Suśrut Samhitā, are the burning problems in herbal medicinal industries. In Aṣṭāṅgahṛdayam) were studied from their 2007, 2008 and many developing countries, medicinal plants have not been 2011 editions [12, 13, 14]. All Sanskrit plant names given in the correctly studied or documented. The extent of knowledge on Mādhava Cikitsā for the treatment of Mūtrakṛcchra were traditional medicines should be documented with correct listed and scrutinized for their Āyurvedic, Vernacular and botanical identification of plants through study of manuscripts Botanical nomenclature with available literature. The Sanskrit and botanical surveys before such rich heritage are lost due to texts, different manuscripts and plant taxonomic literature various anthropogenic and other causes [18]. (Glossaries, Nighantus, Flora, etc) including the official API An attempt has been made by the authors to list out all the & AFI were referred to have a basis for the most probable plants (Sanskrit names) given in Mādhava Cikitsā for the identifications of these plants as per the maximum agreement treatment of Mūtrakṛcchra in the chapter (No. 30) and of names by the authors in references and by adhering to the compare the list with that of Bṛhattrayī. The most probable latest taxonomic principles of nomenclature of ICBN. and correct botanical identification of each plant (including The comparative study of medicinal plants listed from synonyms) was also determined through literature survey. The Bṛhattrayī and Mādhava Cikitsā is explained in the table final list will expectedly help Āyurvedic practitioners and below: herbal companies to understand the correct plant species for CS = Caraka Samhitā, SS= Suśrut Samhitā, AH= the treatment as well as it will help to enrich plant database Aṣṭāṅgahṛdayam, MC= Mādhava Cikitsā regarding medicinal plants for the treatment of renal disorder. Table 1: Plants for Mūtrakṛcchra treatment common in Mādhava Cikitsā and Bṛhattrayī Sr. Botanical name and Family Vernacular Name (s) Sanskrit name (s) Text (s) No. Abutilon indicum L. Sweet. [3, 7, 11, 19, 25, 28, 29, 30] Kākhi, Kākhīyā [28], Kaṅgahi Kangahi [28], Ṛṣyaprōktā [11], Kaṅkatika [11, 25], 1. SS and MC Syn. A. indicum G. Don. [11, 24] [25, 28, 29] Atībalā [11, 25, 28, 30] Malvaceae [3, 7, 11, 19, 24, 25, 28, 29, 30] Alstonia scholaris L. R. Br. [11, 19, Sataunā, Sattivanna [28] Vīśaltvak, Ṣārd, Vīṣamcchad [11, 28], Saptacchada, AH, CS 2. 20, 25, 28, 30, 32] Chativan, Sattavaṇṇa [25, 28, 32] Saptāhvā [11, 25], Saptaparṇa [11, 20, 25, 28, 30, 32] and MC Apocynaceae [11, 19, 20, 25, 28, 30] Amomum subulatum Roxb. [11, 18, Elā, Sathula, Brūhdelā, Caṅdrabala, Nīśakuti [28], Purvi Ilāyacī, Lāl Ilāyacī [28], AH, CS 3. 23, 25, 28, 27] Bahulā, Pṛuthavīkā, Trīputa [11, 28], Sthūlailā [11, 27, Baḍī ilāyacī [23, 25, 28] and MC Zingiberaceae [11, 18, 25, 28] 28], Bhadrailā [10, 11, 25, 28] Anogeissus latifolia Wall. ex. Dhat, Naṅditaru, Gaura [28], Bahaupuṣapi, Bedd. [3, 11, 19, 28, 32] Dhaurā, Dhau, Dhau-vṛukśa 4. Tāmrapuṣapi, Vanījavālā [25], Dhuraṅdharā [11, 28], CS and MC Combretaceae [11, 19, 28] [28], Dhavā [25, 28] Dhava [11, 28, 32] Arundo donax L. Trin. ex Steud. Poṭgala, Śunayāmadhayā, Dhaman [28], Devanala CS, SS and 5. [11, 28, 30] Narasal, Nal [28] [11], Nala [11, 28, 30] MC Poaceae [11, 28, 30] Asparagus racemosus Willd. [3, 4, Śatamūli [11], Abhīru [25], Pīvari [28], Bahusutā, 5, 7, 11, 19, 25, 28, 29, 30, 32, 33] Śarnoī [28], Śatāvari [3, 4, 5, 28], Śatpadi, Śatavīryā, Īṅdivari, Bhīrua [3, 28], Atīrasā CS, SS and 6. Lilieaceae [3, 4, 5, 7, 19, 25, 28, 29, 30] Satāvar, Śatamūli [25, 28] [11, 25], Nārāyaṇi, Vār i [11, 25, 28], Śatāvari [11, 28, 30, 32, MC 33] Berberis aristata DC. [4, 5, 8, 11, 25, Dāru hardī [28], Parjañyā, Parjani, Pīta, Kāliyāk, Kāleyak, Pītdāru, 7. 28, 32] Dārhalad [25, 28], Dāru haldī [4, Haridru, Pītak [11], Dāruharidrā [4, 5, 11, 32], Dārvi [8, CS and MC Berberidaceae [4, 5, 8, 11, 25, 28] 25, 28] 11, 25, 32] Ārvet, Dīrghfalā, Suvarnafala [28], Karnīkāra, Cassia fistula L. [3, 7, 11, 16, 18, 19, 20, Sonhali [28], Girimālā [25], Rājvṛūkṣā, Vyādhighātā, Śvaernak [11, 25, 28], AH, CS 8. 25, 27, 28, 30, 32] Āmaltās [16, 25, 28] Āragvādha [11, 30, 27, 32, 20, 28], Śaṁpaka, Kṛtamāla [11, and MC Caesalpiniaceae [7, 16, 11, 19, 30] 16, 25, 28], Rājvrūkṣa [11, 25, 28, 32] Dēvakāṣṭha, Dāruka, Dēvadruma, Śaptapatrīka [11], Cedrus deodara (Roxb.) Loud [4, Dārubhadra, Īṅdradāru, Maśtadāru, Drukīlīm, 9. 11, 16, 25, 28] Debdār [16, 25, 28] Kīlīm, Śurbhuruha [28], Suradāru [11, 16], CS and MC Pinaceae [8, 11, 25, 28] Bhadradāru, Āmartaru [4, 11, 25], Dāru, Devadāru [4, 11, 16, 25, 28] Cucumis melo L.
Recommended publications
  • Screening of Ferula Narthex Boiss Crude Methanolic Extract for Analgesic, Gastrointestinal Motility and Insecticidal Activity
    Middle-East Journal of Scientific Research 14 (4): 471-475, 2013 ISSN 1990-9233 © IDOSI Publications, 2013 DOI: 10.5829/idosi.mejsr.2013.14.4.286 Screening of Ferula narthex Boiss Crude Methanolic Extract for Analgesic, Gastrointestinal Motility and Insecticidal Activity 1Shumaila Bashir, 1Mahboob Alam, 21Bashir Ahmad, Akhtar Aman and 3Javid Ali 1Department of Pharmacy, University of Peshawar, KPK, Pakistan 2Centre of Biotechnology and Microbiology, University of Peshawar, KPK, Pakistan 3PCSIR Laboratories Complex Peshawar, KPK, Pakistan Abstract: The crude methanolic extract of Ferula narthex (MeFn) was screened for analgesic, GIT motility and insecticidal activity. Acetic acid-induced writhing model was used for assessment of analgesic effect in mice, while charcoal meal model was used for GIT motility assessment. The crude MeFn showed dose dependent analgesic effect, the significant effect was observed with 100 and 200 mg/kg dose. The analgesic effect of diclofenac sodium (standard drug) was greater than crude MeFn. The crude MeFn extract reduced the motility of GIT in mice. The reduction in GIT motility is dose dependent and maximum effect was produced by 200 mg/kg dose. The insecticidal effect was not significant except n-Hexane fraction which possesses moderate activity against all tested insects (maximum 60% against R. dominica). These effects of crude MeFn extract justify its use in folkloric medicines for the management of pain and various gastro-intestinal disorders. Key words: Ferula narthex GIT motility Analgesic Insecticidal Diclofenac sodium Folkloric medicines INTRODUCTION MATERIALS AND METHODS Genus Ferula belongs to family umbelliferae, which Preparation of Crude Extract: In July 2010 comprises 275 genera and 2850 species, which are Ferula narthex plant was collected from Chitral located in distributed throughout the world, especially in Khyber Pakhtunkhwa Pakistan.
    [Show full text]
  • Chemical Composition of Volatile Oil of Ferula Assafoetida L
    International Journal of Research Studies in Agricultural Sciences (IJRSAS) Volume 5, Issue 8, 2019, PP 9-14 ISSN No. (Online) 2454–6224 DOI: http://dx.doi.org/10.20431/2454-6224.0508002 www.arcjournals.org Chemical Composition of Volatile Oil of Ferula Assafoetida L P. Estekhdami1*, A. Nasiri Dehsorkhi2 1M.sc. Agronomy, Shahroud of University in Iran (2008). 2Ph.D. student of Agroecology , Agronomy Department, Agricultural Faculty , University of Zabol, in Iran. *Corresponding Author: P. Estekhdami, M.Sc. Agronomy, Shahroud of University in Iran (2008). Abstract: Asafoetida is an oleo-gum-resin obtained from the exudates of the roots of the Iranian endemic medicinal plant, F. asafoetida. It is used widely all over the world as a flavoring spice in a variety of foods. was analysed by GC and GC/MS. The constituents were identified by their mass spectra and Kovats' indices. Among those, The main constituents were (E)-1-propenyl sec-butyl disulfide (58.9%), (Z)-β-ocimene (11.9%), (E)-β-ocimene (9.0%), β-pinene (5.0%) and (Z)-1-propenyl sec-butyl disulfide (3.9%). Keywords: Asafoetida , GC/MS 1. INTRODUCTION The genus Ferula, the third largest genus of the Apiaceae (alt.Umbelliferae) family,is composed of ca. 180 species (Yaqoob and Nawchoo, 2016), 15 of whichare endemic to Iran (Mozaffarian, 1996),nine species to Turkey, seven to China (Yaqoob and Nawchoo, 2016) and one species to Italy, and the rest are indigenousentities of several other countries.The majority of the Ferula plants have a pungent odor and can beused for different purposes.In the literature, numerous reports have described various biolo- gical and medicinal activities for different essential oils and ex-tracts of the Ferula plants.
    [Show full text]
  • Ethno-Botanic Treatments for Paralysis (Falij) in the Middle East
    Chinese Medicine, 2012, 3, 157-166 http://dx.doi.org/10.4236/cm.2012.34025 Published Online December 2012 (http://www.SciRP.org/journal/cm) Ethno-Botanic Treatments for Paralysis (Falij) in the Middle East Aref Abu-Rabia Ben-Gurion University of the Negev, Beer-Sheva, Israel Email: [email protected] Received April 12, 2012; revised July 24, 2012; accepted August 9, 2012 ABSTRACT The goal of this paper is to describe beliefs and treatments for specific forms of Paralysis (falij) and other nervous dis- orders in the Middle East. Themes to be investigated include, the traditional medicinal practices used to treat Paralysis, as well as their curative methods using traditional herbal medicine. This paper is based on first and secondary sources; interviews with traditional healers, as well as patients who suffered from these disorders. The author found 152 plants species belonging to 58 families (see Appendix) that treat paralysis and other nervous disorders. The most significant plants species are found in the six families of herbs: Labiatae, Compositae, Umbelliferae, Papilionaceae, Liliaceae, and Solanaceae. Keywords: Paralysis; Ethno Botanic Medicine; Middle East 1. Introduction peak in the thirteenth through sixteenth centuries, and later declined during the seventeenth through the nine- The use of plant medicines in the Middle East has his- teenth centuries. Medical information grounded in Arab torical roots in Ancient Arabic medicine, which itself classical medical scholarship of the Middle Ages was was influenced by the ancient medicinal practices of gradually transferred to local traditional healers and to Mesopotamia, Greece, Rome, Persia, and India. During the general public. Arabs relied primarily on their tradi- the Umayyad rule (661-750 A.D.), translations of ancient tional medicine [2].
    [Show full text]
  • Antioxidant and Antimicrobial Activity of Ferula Species' Essential Oils and Plant Extracts and Their Application As the Natural Food Preservatives
    South Asian Research Journal of Natural Products 4(3): 1-23, 2021; Article no.SARJNP.67706 Antioxidant and Antimicrobial Activity of Ferula Species' Essential Oils and Plant Extracts and their Application as the Natural Food Preservatives Milad Daneshniya1,2*, Mohammad Hossein Maleki1,2 , Moein Ali Mohammadi1,2, Kimia Ahangarian1, Vahid Jalali Kondeskalaei1 and Hannaneh Alavi1 1Department of Food Science and Engineering, Faculty of Industrial and Mechanical Engineering, Qazvin Islamic Azad University, Nokhbegan Blvd., PO Box 34185-1416, Qazvin, Iran. 2Young Researchers and Elite Club, Qazvin Branch, Islamic Azad University, Qazvin, Iran. Authors’ contributions This work was carried out in collaboration among all authors. Author MD designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors MHM, MAM and VJK managed the analyses of the study. Authors KA and HA managed the literature searches. All authors read and approved the final manuscript. Article Information Editor(s): (1) Prof. Mohamed Fawzy Ramadan Hassanien, Zagazig University, Egypt. Reviewers: (1) Hiba Riyadh Al-Abodi, University of Al-Qadisiyah, Iraq. (2) Hong Kan, Jilin Agricultural University, China. Complete Peer review History: http://www.sdiarticle4.com/review-history/67706 Received 14 February 2021 Accepted 17 April 2021 Review Article Published 26 April 2021 ABSTRACT Ferula is a genus of perennial herbs in the Apiaceae family. Members of this genus are found mainly in the Mediterranean region and Central Asia, and they have a long history of utilization in traditional medicine for a variety of diseases. The species of this plant have been used for the ole- gum resin, plant extracts, and essential oils.
    [Show full text]
  • SILPHION “…Multis Iam Annis in Ea Terra Non Invenitur…”
    European Botanic Gardens in a Changing World: Insights into EUROGARD VI ɇȻȿɌȻɃɁ – SILPHION “…multis iam annis in ea terra non invenitur…” Monika Kiehn Department of Ancient History, Papyrology and Epigraphy, University of Vienna, Universitätsring 1, 1010 Vienna, Austria, [email protected] Keywords: historic records, botanical identification, Umbelliferae (Apiaceae), Ferula , Narthex , Thapsia , Cachrys Background “As long as many years you can’t find it at this country anymore … ” (Plin.n.h. XIX 39). This statement of Pliny the Elder (23-79 AD) refers to the ancient Silphion plant. Called laserpicium or laser by the Romans, it was a highly recognized useful plant from the Roman province of Cyrenaica (today part of Libya). It was famous as medicine and very expensive: “ ... being sold as the same rate as silver. ” (Plin.n.h. XIX 39). Pliny also tells us the reason why it is not found anymore: the farmers who hold the land there on lease considered it more profitable to bring in flocks of sheep, and, as a result of that grazing, Silphion disappeared from the Cyrenaica. Pliny also reports “ Within the time of our memory, only one single stalk has been found there, and that was sent to the Emperor Nero ” (Plin.n.h. XIX 39) . Why is this plant still so fascinating – even after 2,000 years? Silphion is the first useful plant species said to have become extinct by men. But many scientists do not want to believe that it really has gone forever and hope it might still grow somewhere hidden in Northern Africa and waits for its rediscovery.
    [Show full text]
  • Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula Narthex Exudate
    molecules Article Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate Adnan Amin 1, Emmy Tuenter 1, Paul Cos 2, Louis Maes 2, Vassiliki Exarchou 1, Sandra Apers 1 and Luc Pieters 1,* 1 Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; [email protected] (A.A.); [email protected] (E.T.); [email protected] (V.E.); [email protected] (S.A.) 2 Laboratory of Parasitology, Microbiology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; [email protected] (P.C.); [email protected] (L.M.) * Correspondence: [email protected]; Tel.: +32-3-265-2715 Academic Editor: Thomas J. Schmidt Received: 23 August 2016; Accepted: 22 September 2016; Published: 26 September 2016 Abstract: The exudate of Ferula narthex Boiss. (Apiaceae) is widely used in the Indian subcontinent as a spice and because of its health effects. Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 80-O-acetyl-asacoumarin A, 100R-karatavacinol and 100R-acetyl-karatavacinol. Based on its use in infectious and diabetic conditions, the isolated constituents were evaluated for antimicrobial and antiglycation activities. Some compounds showed activity against protozoal parasites, asacoumarin A being the most active one against Plasmodium falciparum K1 (IC50 1.3 µM). With regard to antiglycation activity, in the BSA-glucose test, ligupersin A displayed the highest activity (IC50 0.41 mM), being more active than the positive control aminiguanidine (IC50 1.75 mM).
    [Show full text]
  • Phytochemical and Biological Investigations on Medicinal Plants from Pakistan
    Faculteit Farmaceutische, Biomedische en Diergeneeskundige Wetenschappen Departement Farmaceutische Wetenschappen Phytochemical and Biological Investigations on Medicinal Plants from Pakistan Proefschrift voorgelegd tot het behalen van de graad van doctor in de farmaceutische wetenschappen aan de Universiteit Antwerpen te verdedigen door Adnan AMIN Promotors Prof. Dr. L. Pieters Prof. Dr. S. Apers Antwerpen, 2016 Perfection is not attainable, but if we chase perfection we can catch excellence. Vince Lombardi To My Mother “Naseem Akhtar” May Allah keep her soul in peace and rest Aameen TABLE OF CONTENTS LIST OF ABBREVIATIONS XV CHAPTER 1 INTRODUCTION AND AIM OF THE WORK 1 1.1 TRADITIONAL MEDICINE 3 1.2 TRADITIONAL MEDICINE AND THE 21st CENTURY MEDICINE 4 MARKET 1.3 ETHNOMEDICINAL ASSESMENT AND DRUG DISCOVERY 5 1.4 TRADITIONAL MEDICINE IN PAKISTAN 6 1.5 DIABETES MELLITUS 7 1.6 ADVANCED GLYCATION END PRODUCTS (AGEs) 8 1.6.1 AGEs and pathogenesis of diabetic complications 10 1.6.2 Natural products as AGEs-inhibiting compounds 11 1.6.3 Polyphenols 11 1.6.4 Flavonoids 12 1.6.5 Terpenes 13 1.6.6 Alkaloids 13 1.6.7 Iridoids 14 1.7 INHIBITION OF α-GLUCOSIDASE 16 1.8 MICROBIAL INFECTIONS 19 1.9 LEISHMANIASIS 22 1.10 MALARIA 25 1.11 AIM OF THIS WORK 29 REFERENCES 33 CHAPTER 2 GENERAL EXPERIMENTAL METHODS 51 2.1 CHROMATOGRAPHIC METHODS 53 TABLE OF CONTENTS VII 2.1.1 Solvents and reagents 53 2.1.2 General extraction scheme 53 2.1.3 Thin layer chromatography 54 2.1.4 Flash chromatography 55 2.1.5 High performance liquid chromatography 55 2.1.6 Semi-preparative
    [Show full text]
  • Unabated Loss of Medicinal Plant Diversity in Himalaya: a Serious Socio-Economic Concern and Urgency to Salvage Whatever Is Left
    Global Advanced Research Journal of Medicinal Plants (GARJMP) Vol. 2(1) pp. 012-021, July, 2013 Available online http://garj.org/garjmms/index.htm Copyright © 2013 Global Advanced Research Journals Full Length Research Paper Unabated loss of medicinal plant diversity in Himalaya: a serious socio-economic concern and urgency to salvage whatever is left Rubaya Sultan 1*, Manzoor Ahmad Wani 1 and Irshad A. Nawchoo 2 1Department of Botany, S.P College, Srinagar 2Department of Botany, University of Kashmir, Srinagar, J and K, India Accepted 08 Feburary, 2013 Aconitum heterophyllum, A. chasmanthum, Atropa accuminata, A. beladdona, Arnebia benthamii, Gentian kurroo, Inula racemosa, I. royleana, Picrorhiza kurrooa, Podophyllum hexandrum, Rheum emodi and Saussurea costus are few of the most important medicinal herbs of north western Himalayan region including Kashmir. These herbs are endemic to the region and confined to alpine-sub alpine habitats (2150m-4000m Amsl) which register near arctic severity for some part of the year. Ecologically these niches are unique and highly specialized. Any alterations are bound to affect the very survival of these herbs. Unfortunately, numerous anthropogenic influences have altered most of these habitats which has caused irreparable damage to this invaluable germplasm leading to the ecological and socio-economic consequences of immediate concern. Whatever is left now is faced with onslaught of indiscriminate exploitation for economic gains. These species reproduce both by vegetative as well as sexual means. The flowers are hermaphrodite. The sex tracks being temporarily isolated, the herbs outbreed and set copious quantities of seed. The sexual potential however, does not match the actual requirement for regeneration which would have otherwise ensured sustained supply of the drug to the industry.
    [Show full text]
  • Therapeutic Utilization of Secretory Products of Some .Indian Medicinal Plants - a Review
    Indian Journal of Traditional Knowledge Vol 5(4), October 2006, pp 569-575 Therapeutic utilization of secretory products of some .Indian medicinal plants - a review 2 Mradu Gupra", Tuhin Kant Biswas , Shyamali Saha' & Pratip Kumar Debnath ' I Department of Dravyaguna Vijnana, 2Department of Sharir Kriya, 3Department of Kayachikitsa, JB Roy State Ayurvedic College & Hospital, 170-172, Raja Dinendra Street, Kolkaia 700004, West Bengal Email: mradu_gupta@hotmaiLcom Received 29 June 2005; revised 5 September 2005 Indian Systems of Medicine use around eight thousand medicinal plants in preventive, promotive and curative applications. Although the bark and roots are the most common plant parts used, depending on the potency other plant parts such as leaves, flowers, stem, secretory products, etc. are also used as medicine. Secretory products include secretions obtained either naturally or by making incisions in the plant. External secretory structures include trichornes, glands, nectaries, hydathodes and osmophores while the internal secretory structures located below the epidermis layer consist of thc glands and ducts, which secrete oils, gums and resins, and laticifers, which secrete latex. Detailed study of a few commonly found secreting Indian medicinal plants exhibits pharrnacochemical properties and therapeutic actions. Keywords: Ayurveda, Clinical activity. Medicinal plants. Pharmacological activities. Review. Secretory products IPC Int. CI.H:A61 K36/00, A61 P1I04, A61 P 1106, A61 PIIIO, A61 P11I2, A61 P1I14, A61P5/00, A61 P5/50. A61 PI 1100, A61PllI10, A61 P 15/00, A61 P 17/00, A61 P 17/02. A61 P 19/00. A61 P 19/02, A61 P21100. A61 P39/02 India is endowed with herbal wealth of about 5000 Charaka Samhita, milky secretory plant products can plant species of known medicinal and aromatic be put to medicinal uses".
    [Show full text]
  • Next Chapter in the Legend of Silphion
    plants Article Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event Mahmut Miski Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey; [email protected] or [email protected]; Tel.: +90-545-550-4455 Abstract: Silphion was an ancient medicinal gum-resin; most likely obtained from a Ferula species growing in the Cyrene region of Libya ca. 2500 years ago. Due to its therapeutic properties and culinary value, silphion became the main economic commodity of the Cyrene region. It is generally believed that the source of silphion became extinct in the first century AD. However, there are a few references in the literature about the cultivated silphion plant and its existence up to the fifth century. Recently, a rare and endemic Ferula species that produces a pleasant-smelling gum-resin was found in three locations near formerly Greek villages in Anatolia. Morphologic features of this species closely resemble silphion, as it appears in the numismatic figures of antique Cyrenaic coins, and conform to descriptions by ancient authors. Initial chemical and pharmacological investigations of this species have confirmed the medicinal and spice-like quality of its gum-resin supporting a connection with the long-lost silphion. A preliminary conservation study has been initiated at the growth site of this rare endemic Ferula species. The results of this study and their implications on the regional extinction event, and future development of this species will be discussed. Citation: Miski, M. Next Chapter in the Legend of Silphion: Preliminary Keywords: silphion; Ferula; F.
    [Show full text]
  • (Ferula Assa-Foetida) Oleo-Gum-Resin Extract on Guinea-Pig Tracheal S
    Avicenna Journal of Phytomedicine Received: July 19, 2011; Accepted: Aug 9, 2011 Vol. 2, No. 1, Winter 2012, 10-16 Possible mechanism(s) of the relaxant effect of asafoetida (Ferula assa-foetida ) oleo-gum-resin extract on guinea-pig tracheal smooth muscle Zahra Gholamnezhad 1, Goltaj Byrami 1, Mohammad Hossein Boskabady 1*, Mehrdad Iranshahi 2 Abstract Objective: Asafoetida (Ferula assa-foetida ) is known as a valuable remedy for whooping cough, pneumonia, bronchitis in children and asthma treatment in folk medicine. In the present study the relaxant effects of the asafoetida on tracheal smooth muscle of guinea pigs and its probable mechanism(s) were examined. Materials and Methods: The relaxant effects of three cumulative concentrations of the aqueous extract (2, 5 and 10 mg/ml), theophylline (0.25, 0.5 and 0.75 mM) and saline were examined on non-incubated tracheal smooth muscle of guinea pig precontracted by 10 µM methacholine (group 1); preincubated tissues by propranolol and chlorpheniramine, contracted by methacholine (group 2) and preincubated tissues by propranolol, contracted by methacholine (group 3), (n=6 for each group). Results: All concentrations of theophylline in group 1 and all concentrations of the extract in the other three groups showed significant relaxant effects compared to that of saline (p<0.001 for all cases). There was not significant difference in the relaxant effect of the extract between three groups. The relaxant effects of two last concentrations of the extract (5 and 10 mg/ml) only in group 2 were significantly lower than that of theophylline (p<0.05 for both case).
    [Show full text]
  • Cephalopodum Badachschanicum, Semenovia Vachanica
    Skvortsovia: 1(2): 149 – 168 (2014) Skvortsovia ISSN 2309-6497 (Print) Copyright: © 2014 Russian Academy of Sciences http://skvortsovia.uran.ru/ ISSN 2309-6500 (Online) Article Cephalopodum badachschanicum, Semenovia vachanica and other Umbelliferae (Apiaceae) novelties of Afghan flora from Badakhshan Province, with notes on some species of the Pamirs. Mikhail G. Pimenov*, Evgeniy V. Kljuykov and Uliana A. Ukrainskaja Botanical Garden, Moscow State University, bldg. 34, Vorobjevy Gory, Moscow 119234, Russia *Corresponding author. Email: [email protected] Received: 28 November 2013 | Accepted by: Rafaël H.A. Govaerts: 26 March 2014 | Published on line: 30 April 2014 Abstract We report here on some Umbelliferae taxa that have been collected for the first time in the area of Afghan Badakhshan that borders Tajikistan. They include Cephalopodum badachschanicum, Elaeosticta hirtula, Heracleum lehmannianum, Semenovia imbricata, and Semenovia vachanica. The distribution of Ferula gigantea in Afghan Badakhshan was confirmed by a herbarium collection. Following comparative studies of plants from Tajik and Afghan Badakhshan the nomenclature of Angelica komarovii, Conioselinum tataricum and Pseudotrachydium dichotomum, as given in Rechinger’s ‘Flora Iranica,’ was revised. In total, 21 species of the Umbelliferae are critically analyzed. Keywords: Afghanistan, Badakhshan, Cephalopodum, Elaeosticta, Ferula, Heracleum, Semenovia, Umbelliferae Introduction The narrow gorge of the Pyandj River cuts the territory of Badakhshan into Tajik and Afghan parts. In the 1870s it was suggested that the gorge be considered as the frontier between areas of British and Russian interests. The valley later became the USSR-Afghanistan and finally the Tajikistan-Afghanistan border. Botanical investigations in both parts of this unique territory have been carried out independently and, as a result, there are some inexplicable differences between plant lists of Tajik and Afghan Badakhshan, including those on Umbelliferae distribution.
    [Show full text]