Ethno-Botanic Treatments for Paralysis (Falij) in the Middle East
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Screening of Ferula Narthex Boiss Crude Methanolic Extract for Analgesic, Gastrointestinal Motility and Insecticidal Activity
Middle-East Journal of Scientific Research 14 (4): 471-475, 2013 ISSN 1990-9233 © IDOSI Publications, 2013 DOI: 10.5829/idosi.mejsr.2013.14.4.286 Screening of Ferula narthex Boiss Crude Methanolic Extract for Analgesic, Gastrointestinal Motility and Insecticidal Activity 1Shumaila Bashir, 1Mahboob Alam, 21Bashir Ahmad, Akhtar Aman and 3Javid Ali 1Department of Pharmacy, University of Peshawar, KPK, Pakistan 2Centre of Biotechnology and Microbiology, University of Peshawar, KPK, Pakistan 3PCSIR Laboratories Complex Peshawar, KPK, Pakistan Abstract: The crude methanolic extract of Ferula narthex (MeFn) was screened for analgesic, GIT motility and insecticidal activity. Acetic acid-induced writhing model was used for assessment of analgesic effect in mice, while charcoal meal model was used for GIT motility assessment. The crude MeFn showed dose dependent analgesic effect, the significant effect was observed with 100 and 200 mg/kg dose. The analgesic effect of diclofenac sodium (standard drug) was greater than crude MeFn. The crude MeFn extract reduced the motility of GIT in mice. The reduction in GIT motility is dose dependent and maximum effect was produced by 200 mg/kg dose. The insecticidal effect was not significant except n-Hexane fraction which possesses moderate activity against all tested insects (maximum 60% against R. dominica). These effects of crude MeFn extract justify its use in folkloric medicines for the management of pain and various gastro-intestinal disorders. Key words: Ferula narthex GIT motility Analgesic Insecticidal Diclofenac sodium Folkloric medicines INTRODUCTION MATERIALS AND METHODS Genus Ferula belongs to family umbelliferae, which Preparation of Crude Extract: In July 2010 comprises 275 genera and 2850 species, which are Ferula narthex plant was collected from Chitral located in distributed throughout the world, especially in Khyber Pakhtunkhwa Pakistan. -
Chemical Composition of Volatile Oil of Ferula Assafoetida L
International Journal of Research Studies in Agricultural Sciences (IJRSAS) Volume 5, Issue 8, 2019, PP 9-14 ISSN No. (Online) 2454–6224 DOI: http://dx.doi.org/10.20431/2454-6224.0508002 www.arcjournals.org Chemical Composition of Volatile Oil of Ferula Assafoetida L P. Estekhdami1*, A. Nasiri Dehsorkhi2 1M.sc. Agronomy, Shahroud of University in Iran (2008). 2Ph.D. student of Agroecology , Agronomy Department, Agricultural Faculty , University of Zabol, in Iran. *Corresponding Author: P. Estekhdami, M.Sc. Agronomy, Shahroud of University in Iran (2008). Abstract: Asafoetida is an oleo-gum-resin obtained from the exudates of the roots of the Iranian endemic medicinal plant, F. asafoetida. It is used widely all over the world as a flavoring spice in a variety of foods. was analysed by GC and GC/MS. The constituents were identified by their mass spectra and Kovats' indices. Among those, The main constituents were (E)-1-propenyl sec-butyl disulfide (58.9%), (Z)-β-ocimene (11.9%), (E)-β-ocimene (9.0%), β-pinene (5.0%) and (Z)-1-propenyl sec-butyl disulfide (3.9%). Keywords: Asafoetida , GC/MS 1. INTRODUCTION The genus Ferula, the third largest genus of the Apiaceae (alt.Umbelliferae) family,is composed of ca. 180 species (Yaqoob and Nawchoo, 2016), 15 of whichare endemic to Iran (Mozaffarian, 1996),nine species to Turkey, seven to China (Yaqoob and Nawchoo, 2016) and one species to Italy, and the rest are indigenousentities of several other countries.The majority of the Ferula plants have a pungent odor and can beused for different purposes.In the literature, numerous reports have described various biolo- gical and medicinal activities for different essential oils and ex-tracts of the Ferula plants. -
Through Our French Window Gordon James
©Gordon James ©Gordon Through our French window Gordon James Fig. 1 Asphodelus ramosus n 2014 I wrote an article above the hamlet of Le attention – systematically I for this journal about Clapier where we have a perhaps, dealing with the the orchids that grow on small house, and covers an Ranunculaceae family first, and around a limestone area of perhaps 25km2 lying but that could prove a little plateau in Southern France 750–850m above sea level dull; or perhaps according to called the Plateau du which, together with the season. In the end I decided Guilhaumard, which is surrounding countryside, simply to pick out some of situated on the southern supports an extraordinarily our favourites. With a few edge of the great Causse rich range of plants besides exceptions all the plants du Larzac, a limestone orchids. mentioned in this article karst plateau in the south I wasn’t sure how best can be reached on foot from of the Massif Central. to introduce the plants our house by moderately fit Guilhaumard rises steeply I think deserve special pensioners like us! ©Gordon James ©Gordon James ©Gordon Fig. 2 Asphodelus ramosus Fig. 3 Narcissus assoanus 371 ©Gordon James ©Gordon James ©Gordon Fig. 4 Narcissus poeticus Fig. 5 Iris lutescens Despite its elevation, I will start with those summers are hot, as the plants which, at least for a Plateau is relatively far moment, carpet the ground toward the South of and foremost amongst these ©Gordon James ©Gordon France, though it can be is Asphodelus ramosus (syn. quite cold and snowy A. -
Enantioselective Synthesis of Bioactive Molecules Via
ENANTIOSELECTIVE SYNTHESIS OF BIOACTIVE MOLECULES VIA ASYMMETRIC HYDROXYLATIONS, AMINOALLYLATION AND SYNTHETIC METHODOLOGIES INVOLVING ACTIVATION OF C-H BONDS A THESIS SUBMITTED TO THE UNIVERSITY OF PUNE FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN CHEMISTRY By TANVEER MAHAMADALI SHAIKH UNDER THE GUIDANCE Dr. A. Sudalai Chemical Engineering and Process Development Division National Chemical Laboratory Pune-411008, INDIA November 2009 Dedicated to my beloved parents & brother Raziya Mahamadali & Sameer NATIONAL CHEMICAL LABOATORY Dr. A. Sudalai Scientist Chemical Engineering & Process Development Division, Pune – 411 008, India Phone (O) : 0091-20-25902174, Fax: 0091-20-25902676, e-mail: [email protected] CERTIFICATE Certified that the work incorporated in the thesis entitled “Enantioselective Synthesis of Bioactive Molecules via Asymmetric Hydroxylations, Aminoallylation and Synthetic Methodologies Involving Activation of C-H Bonds” was carried out by the candidate under my supervision. Such material as had been obtained from other sources has been duly acknowledged in the thesis. November 2009 (Dr. A. Sudalai) Pune Research Supervisor NATIONAL CHEMICAL LABORATORY DECLARATION I here by declare that the thesis entitled “Enantioselective Synthesis of Bioactive Molecules via Asymmetric Hydroxylations, Aminoallylation and Synthetic Methodologies Involving Activation of C-H Bonds” submitted for the degree of Doctor of Philosophy in Chemistry to the University of Pune, has not been submitted by me to any other university or institution. This -
Possible Uses of Plants of the Genus Asphodelus in Oral Medicine
biomedicines Communication Possible Uses of Plants of the Genus Asphodelus in Oral Medicine Mario Dioguardi 1,* , Pierpaolo Campanella 1, Armando Cocco 1, Claudia Arena 1, Giancarlo Malagnino 1, Diego Sovereto 1, Riccardo Aiuto 2, Luigi Laino 3, Enrica Laneve 1, Antonio Dioguardi 1, Khrystyna Zhurakivska 1 and Lorenzo Lo Muzio 1 1 Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy; [email protected] (P.C.); [email protected] (A.C.); [email protected] (C.A.); [email protected] (G.M.); [email protected] (D.S.); [email protected] (E.L.); [email protected] (A.D.); [email protected] (K.Z.); [email protected] (L.L.M.) 2 Department of Biomedical, Surgical, and Dental Science, University of Milan, 20122 Milan, Italy; [email protected] 3 Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples, Italy; [email protected] * Correspondence: [email protected] Received: 19 August 2019; Accepted: 29 August 2019; Published: 2 September 2019 Abstract: Among the many plants used in traditional medicine we have the plants of the genus Asphodelus, which are present in the Mediterranean area in North Africa and South East Asia, and have been used by indigenous peoples until recently for various pathologies, including: Psoriasis, alopecia areata, acne, burns, nephrolithiasis, toothache, and local inflammation. The scientific literature over the last five years has investigated the various effects of the metabolites extracted from plants of the genus Asphodelus, paying attention to the diuretic, antihypertensive, antimicrobial, anti-inflammatory, and antioxidant effects, and it also has begun to investigate the antitumor properties on tumor cell lines. -
SYNTHESIS Journal Of
Journal of Synthetic Organic SYNTHESIS Chemistry REPRINT With compliments of the Author Thieme SHORT REVIEW ▌2551 short review Conhydrine: An Account of Isolation, Biological Perspectives and Synthesis l ChinmayConhydrine: A Short Review Bhat,*a Sandesh T. Bugde,b Santosh G. Tilve*b a Centre for Nano and Material Sciences, Jain Global Campus, Jakkasandara Post, Kanakapura Road, Ramanagara District, Karnataka 562 112, India b Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206, India Fax +91(832)6519317; Fax +91(965)7962641; E-mail: [email protected]; E-mail: [email protected] Received: 23.05.2014; Accepted after revision: 06.08.2014 Abstract: Conhydrine is a naturally occurring 2-substituted piperi- dine alkaloid from the plant Conium maculatum L that exists in four different forms and is known for its high toxicity. This article focus- es on the synthesis of conhydrine as its medicinal applications are limited due to its high toxicity. The various asymmetric methods de- veloped for the synthesis of conhydrine are classified based on the methodology: the chiral pool method, the chiral auixiliary method, and asymmetric catalysis. A brief overview of the complete synthet- ic coverage of conhydrine (1948–2014) in different isomeric forms is given. Dr. Chinmay Bhat was born in Sirsi, Karnataka, India. He moved to 1 Introduction the Department of Chemistry, Goa University in 2006 for his M.Sc. 2 Isolation and Biological Perspectives in chemistry. After qualifying CSIR-NET-JRF in 2007, he joined the 3 Synthesis group of Prof. Santosh Tilve in 2008 in the doctoral programme and 3.1 Chiral Pool Methods worked on the asymmetric synthesis of natural products. -
Maculatum L.).-Ii Evidence for a Rapid Turnover of the Major Alkaloids
Phytochcmistry.1961. Vol. 1. pp. 38to 46. Pqamon PressLtd. Printedin lh&id THE ALKALOIDS OF HEMLOCK (CONIUM MACULATUM L.).-II EVIDENCE FOR A RAPID TURNOVER OF THE MAJOR ALKALOIDS J. W. FAIRBAIRN and P. N. SUWAL School of Pharmacy, Brunswick Square, London, W.C.1 (Received 14 February 1961) Abstract-Previous work, based on analyses of samples of &loping fruits collected at weekly intervatS, has been confirmed. Samples wem also collected at 4-hourly and 2-hourly intervals and analyses showed that remarkably rapid changes in the alkaloidal picture took place at short intervals during 24 hr. Further- more, as the coniine (I) content increased, the y-coniceine (II) content decreased and vice versa. This interrelationship was particularly marked during the critical stages of pericarp development, but was not obvious during the development of the vegetative parts, where y-coniceine and conhydrine (III) were the only known alkaloids detected. Since coniine and yconiceine differ only by two hydrogen atoms, it is suggested that these two alkaloids are involved in oxidation-reduction processes in the developing pericarp. The occurrence of the minor alkaloids conhydriie and N-methyl coniine (1V) and the presence of some unknown alkaloids are also reported and commented on. INTRODUCTION IN A previous communication’ it was shown that the total alkaloidal content and the CH(OH)CH$H, proportions of individual alkaloids in hemlock fruit varied with the development of the fruit and with the season. It was suggested that y-coniceine (11) was the precursor of the saturated alkaloids, such as coniine (I), and that this change, which appeared to be rever- sible, is associated with active grbwth. -
Identification and Determination of Unusual Functional Groups
IDENTIFICATION AND DETERMINATION OF UNUSUAL FUNCTIONAL GROUPS E. SAWICKI U.S. Department of Health, Education and Weifare, Cincinnati, Ohio 45226, U.S.A. INTRODUCTION Many of the unusual and unfamiliar analytical methods of yesterday have become the common methods of today. Therefore, when we speak of "unusual" functional groups we refer to those that are now novel but that may evolve with time and use into the usual and well-known. With advances in knowledge of the physical and chemical properties of organic molecules, new types of functional groups are being found, some of which appear strange and unusual at the moment while others are more sharply delineated sub-divisions of well-known functional groups. The sub-divisional functional group contains the original functional group with additional atoms; for example, one sub-division of a ketonic C =Ü func tional group is the -CHz-CO-CH3 grouping. Methods of analysis for compounds containing such a sub-divisional grouping are usually more highly selective. Examples will be given of some well-known families of compounds, each theoretically containing a common functional group which, until recently, had not been exploited for analytical purposes. Environmental health problems have proliferated tremendously in the past 40 years mainly because of the growing complex.ity of the chemical environment in which we live. Examples of this phenomenon are smog and the growing dinginess of the urban atmosphere; this dinginess indicates the accelerating infiltration of our air by man-made pollutants. Because of the increasing chemical pollution of our environment and its sometimes adverse effect on man, other life forms, and man-made objects, it is necessary first to determine the composition of the complicated mixtures with which we are in contact and then to decrease the concentrations ofthe harmful compounds. -
Antioxidant and Antimicrobial Activity of Ferula Species' Essential Oils and Plant Extracts and Their Application As the Natural Food Preservatives
South Asian Research Journal of Natural Products 4(3): 1-23, 2021; Article no.SARJNP.67706 Antioxidant and Antimicrobial Activity of Ferula Species' Essential Oils and Plant Extracts and their Application as the Natural Food Preservatives Milad Daneshniya1,2*, Mohammad Hossein Maleki1,2 , Moein Ali Mohammadi1,2, Kimia Ahangarian1, Vahid Jalali Kondeskalaei1 and Hannaneh Alavi1 1Department of Food Science and Engineering, Faculty of Industrial and Mechanical Engineering, Qazvin Islamic Azad University, Nokhbegan Blvd., PO Box 34185-1416, Qazvin, Iran. 2Young Researchers and Elite Club, Qazvin Branch, Islamic Azad University, Qazvin, Iran. Authors’ contributions This work was carried out in collaboration among all authors. Author MD designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors MHM, MAM and VJK managed the analyses of the study. Authors KA and HA managed the literature searches. All authors read and approved the final manuscript. Article Information Editor(s): (1) Prof. Mohamed Fawzy Ramadan Hassanien, Zagazig University, Egypt. Reviewers: (1) Hiba Riyadh Al-Abodi, University of Al-Qadisiyah, Iraq. (2) Hong Kan, Jilin Agricultural University, China. Complete Peer review History: http://www.sdiarticle4.com/review-history/67706 Received 14 February 2021 Accepted 17 April 2021 Review Article Published 26 April 2021 ABSTRACT Ferula is a genus of perennial herbs in the Apiaceae family. Members of this genus are found mainly in the Mediterranean region and Central Asia, and they have a long history of utilization in traditional medicine for a variety of diseases. The species of this plant have been used for the ole- gum resin, plant extracts, and essential oils. -
SILPHION “…Multis Iam Annis in Ea Terra Non Invenitur…”
European Botanic Gardens in a Changing World: Insights into EUROGARD VI ɇȻȿɌȻɃɁ – SILPHION “…multis iam annis in ea terra non invenitur…” Monika Kiehn Department of Ancient History, Papyrology and Epigraphy, University of Vienna, Universitätsring 1, 1010 Vienna, Austria, [email protected] Keywords: historic records, botanical identification, Umbelliferae (Apiaceae), Ferula , Narthex , Thapsia , Cachrys Background “As long as many years you can’t find it at this country anymore … ” (Plin.n.h. XIX 39). This statement of Pliny the Elder (23-79 AD) refers to the ancient Silphion plant. Called laserpicium or laser by the Romans, it was a highly recognized useful plant from the Roman province of Cyrenaica (today part of Libya). It was famous as medicine and very expensive: “ ... being sold as the same rate as silver. ” (Plin.n.h. XIX 39). Pliny also tells us the reason why it is not found anymore: the farmers who hold the land there on lease considered it more profitable to bring in flocks of sheep, and, as a result of that grazing, Silphion disappeared from the Cyrenaica. Pliny also reports “ Within the time of our memory, only one single stalk has been found there, and that was sent to the Emperor Nero ” (Plin.n.h. XIX 39) . Why is this plant still so fascinating – even after 2,000 years? Silphion is the first useful plant species said to have become extinct by men. But many scientists do not want to believe that it really has gone forever and hope it might still grow somewhere hidden in Northern Africa and waits for its rediscovery. -
Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis "227
ReviewReview EnzymaticEnzymatic KineticKinetic ResolutionResolution ofof 2-Piperidineethanol2-Piperidineethanol forfor thethe EnantioselectiveEnantioselective TargetedTargeted andand DiversityDiversity OrientedOriented SynthesisSynthesis †† DarioDario PerdicchiaPerdicchia *,*, MichaelMichael S.S. Christodoulou,Christodoulou, GaiaGaia Fumagalli,Fumagalli, FrancescoFrancescoCalogero, Calogero, CristinaCristina MarucciMarucci andand DanieleDaniele PassarellaPassarella ** Received:Received: 22 NovemberNovember 2015;2015; Accepted:Accepted: 1515 DecemberDecember 2015;2015; Published:Published: 242015 December 2015 AcademicAcademic Editor:Editor: VladimírVladimír KˇrenKřen DipartimentoDipartimento didi Chimica,Chimica, UniversitaUniversita deglidegli StudiStudi didi Milano,Milano,Via Via Golgi Golgi 19, 19, 20133 20133 Milano, Milano, Italy; Italy; [email protected]@gmail.com (M.S.C.);(M.S.C.); [email protected]@unimi.it (G.F.);(G.F.); [email protected]@gmail.com (F.C.);(F.C.); [email protected]@unimi.it (C.M.)(C.M.) ** Correspondences:Correspondences: [email protected] [email protected] (D (D.Pe.);.Pe.); [email protected] [email protected] (D.Pa.); (D.Pa.); Tel.:Tel.: +39-02-5031-4155 +39-02-5031-4155 (D.Pe.); (D.Pe.); +39-02-5031-4081 +39-02-5031-4081 (D.Pa.); (D.Pa.); Fax:Fax: +39-02-5031-4139 +39-02-5031-4139 (D.Pe.); (D.Pe.); +39-02-5031-4078 +39-02-5031-4078 (D.Pa.) (D.Pa.) †† This This paper paper is is dedicated dedicated to to the the memory memory of of Brun Brunoo Danieli, Danieli, Professor Professor of of Organic Organic Chemistry, Chemistry, UniversitàUniversità degli degli Studi Studi di di Milano, Milano, 20122 20122 Milano, Milano, Italy. Italy. Abstract:Abstract: 2-Piperidineethanol2-Piperidineethanol ((11)) andand itsits correspondingcorresponding NN-protected-protected aldehydealdehyde ((22)) werewere usedused forfor thethe synthesissynthesis ofof severalseveral natural natural and and synthetic synthetic compounds. -
Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula Narthex Exudate
molecules Article Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate Adnan Amin 1, Emmy Tuenter 1, Paul Cos 2, Louis Maes 2, Vassiliki Exarchou 1, Sandra Apers 1 and Luc Pieters 1,* 1 Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; [email protected] (A.A.); [email protected] (E.T.); [email protected] (V.E.); [email protected] (S.A.) 2 Laboratory of Parasitology, Microbiology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; [email protected] (P.C.); [email protected] (L.M.) * Correspondence: [email protected]; Tel.: +32-3-265-2715 Academic Editor: Thomas J. Schmidt Received: 23 August 2016; Accepted: 22 September 2016; Published: 26 September 2016 Abstract: The exudate of Ferula narthex Boiss. (Apiaceae) is widely used in the Indian subcontinent as a spice and because of its health effects. Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 80-O-acetyl-asacoumarin A, 100R-karatavacinol and 100R-acetyl-karatavacinol. Based on its use in infectious and diabetic conditions, the isolated constituents were evaluated for antimicrobial and antiglycation activities. Some compounds showed activity against protozoal parasites, asacoumarin A being the most active one against Plasmodium falciparum K1 (IC50 1.3 µM). With regard to antiglycation activity, in the BSA-glucose test, ligupersin A displayed the highest activity (IC50 0.41 mM), being more active than the positive control aminiguanidine (IC50 1.75 mM).