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Datasheet Inhibitors / Agonists / Screening Libraries a DRUG SCREENING EXPERT Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT Product Name : Rocuronium bromide Catalog Number : T0156 CAS Number : 119302-91-9 Molecular Formula : C32H53BrN2O4 Molecular Weight : 609.68 Apprearence : Solid Melting Point : 162-164°C Description: Rocuronium is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation. Storage: 2 years -80°C in solvent; 3 years -20°C powder; DMSO 113 mg/mL (185.3 mM) Ethanol 113 mg/mL (185.3 mM) Solubility Water 112 mg/mL (183.7 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble ) Receptor (IC50) mAChR In vitro Activity Rocuronium bromide (RB), an aminosteroid type neuromuscular blocking agent, acts by reducing or inhibiting the depolarising effect of acetylcholine on the terminal disc of the muscle cell. [1] Rocuronium interacts with human liver microsomal cytochromes P450 (CYP) by binding to the substrate site. Rocuronium has caused inhibition of both reactions by 20 and 15%, respectively. [2] In vivo Activity Rocuronium is an ideal muscle relaxant with a rapid onset, intermediate duration of action, nondepolarizing properties and lack of cardiovascular side effects. Rocuronium produces a dose-dependent duration of neuromuscular blockade in isoflurane anesthetized horses. [3] Rocuronium bromide, is a relatively low potency, intermediate-acting agent with a rapid onset time of 98 seconds in dogs. [4] Rocuronium is an effective nondepolarizing muscle relaxant in the cat under the clinical conditions of this study. Rocuronium has a rapid onset, a short duration of action. [5] Rocuronium (0.6 mg/kg) results in a significant increase in heart rate one min after IV administration in the dog. Rocuronium (0.3 mg/kg and 0.6 mg/kg) produce a reliable neuromuscular block of 23–32 min duration, respectively. [6] Rocuronium bromide paralyzes the internal laryngeal muscles keeping the vocal cords in an intermediate position (paramedial) 60 seconds after being administered in cats. [7] Reference 1. Zan U, et al. Cytotechnology,2011, 63(3), 239-245. 2. Anzenbacherova E, et al. J Pharmacol Sci,2015, 127(2), 190-195. 3. Auer U, et al. Vet Ophthalmol,2011, 14(4), 244-247. 4. Tachibana M, et al. Pharmacology,2003, 68(2), 96-104. 5. Auer U, et al. Vet Anaesth Analg,2006, 33(4), 224-228. 6. Auer U, et al. Vet J,2007, 173(2), 422-427. 7. Moreno-Sala A, et al. Vet Anaesth Analg,2013, 40(4), 351-358. FOR RESEARCH PURPOSES ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE. Information for product storage and handling is indicated on the product datasheet. Targetmol products are stable for long term under the recommended storage conditions. Our products may be shipped under different conditions as many of them are stable in the short-term at higher or even room temperatures. We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, please follow the storage recommendations on the product data [email protected] | Tel: +1-781-999-4286 | www.targetmol.com Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT sheet. [email protected] | Tel: +1-781-999-4286 | www.targetmol.com.
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  • Comparative Study of Different Doses of Rocuronium Bromide For
    MedDocs Publishers Annals of Anesthesia and Pain Medicine Open Access | Research Article Comparative study of different doses of rocuronium bromide for endotracheal intubation Nidhi V Sardhara1*; Sonal A Shah2; Dhaval P Pipaliya3; Shivansh Gupta3 1SVP hospital, 13th floor, Room no 13125, Near Ellis bridge, Ahmedabad, Gujarat-380006 2Assistant Professor, Department of anesthesia, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India 3First year Resident, Department of anesthesia, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India *Corresponding Author(s): Nidhi V Sardhara Abstract SVP hospital, 13th floor, Room no 13125, Near Ellis Background: Endotracheal intubation is one of such bridge, Ahmedabad, Gujarat-380006 development without which general anesthesia cannot be Tel: +91-9428-44-7878, Fax: 7926-57-8452 considered safe for any major surgery particularly head and Email: [email protected] neck, thoracic and abdominal surgeries. Ever since the ad- vent of anesthesia, anesthesiologists have been in search of an ideal muscle relaxants which can provide ideal intu- bating conditions in ultrashort duration with minimal side effects. Rocuronium bromide provides fast onset of action, Received: Mar 11, 2020 an intermediate duration of action and rapid recovery, good Accepted: Apr 24, 2020 to excellent intubating conditions at doses having minimal Published Online: Apr 30, 2020 or no haemodynamic changes. Present study is to compare the effect of different doses (0.6 mg/kg, 0.9 mg/kg, 1.2 mg/ Journal: Annals of Anesthesia and Pain Medicine kg) of Rocuronium bromide for endotracheal intubation at Publisher: MedDocs Publishers LLC 60 seconds. Online edition: http://meddocsonline.org/ Material and methods: This study was carried out by Copyright: © Sardhara NV (2020).
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