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Bevacizumab Plus Fotemustine As First-Line Treatment in Metastatic Melanoma Patients: Clinical Activity and Modulation of Angiogenesis and Lymphangiogenesis Factors
Published OnlineFirst October 28, 2010; DOI: 10.1158/1078-0432.CCR-10-2363 Clinical Cancer Cancer Therapy: Clinical Research Bevacizumab plus Fotemustine as First-line Treatment in Metastatic Melanoma Patients: Clinical Activity and Modulation of Angiogenesis and Lymphangiogenesis Factors Michele Del Vecchio1, Roberta Mortarini2, Stefania Canova1, Lorenza Di Guardo1, Nicola Pimpinelli3, Mario R. Sertoli4, Davide Bedognetti4, Paola Queirolo5, Paola Morosini6, Tania Perrone7, Emilio Bajetta1, and Andrea Anichini2 Abstract Purpose: To assess the clinical and biological activity of the association of bevacizumab and fotemustine as first-line treatment in advanced melanoma patients. Experimental Design: Previously untreated, metastatic melanoma patients (n ¼ 20) received bevaci- zumab (at 15 mg/kg every 3 weeks) and fotemustine (100 mg/m2 by intravenous administration on days 1, 8, and 15, repeated after 4 weeks) in a multicenter, single-arm, open-label, phase II study. Primary endpoint was the best overall response rate; other endpoints were toxicity, time to progression (TTP), and overall survival (OS). Serum cytokines, angiogenesis, and lymphangiogenesis factors were monitored by multiplex arrays and by in vitro angiogenesis assays. Effects of fotemustine on melanoma cells, in vitro, on vascular endothelial growth factor (VEGF)-C release and apoptosis were assessed by ELISA and flow cytometry, respectively. Results: One complete response, 2 partial responses (PR), and 10 patients with stable disease were observed. TTP and OS were 8.3 and 20.5 months, respectively. Fourteen patients experienced adverse events of toxicity grade 3–4. Serum VEGF-A levels in evaluated patients (n ¼ 15) and overall serum proangiogenic activity were significantly inhibited. A significant reduction in VEGF-C levels was found in several post-versus pretherapy serum samples. -
Clinical Evaluation of Pipecuronium Bromide and Its Comparison With
Scholars Journal of Applied Medical Sciences (SJAMS) ISSN 2320-6691 (Online) Sch. J. App. Med. Sci., 2013; 1(6):943-950 ISSN 2347-954X (Print) ©Scholars Academic and Scientific Publisher (An International Publisher for Academic and Scientific Resources) www.saspublisher.com Research Article Clinical Evaluation of Pipecuronium Bromide and its Comparison with Pancuronium Bromide Kaushal RP Associate Professor, Department of cardiac anesthesia, Gandhi Medical College, Bhopal, India. *Corresponding author Kaushal RP Email: Abstract: The study was carried out to compare the intubating conditions, cardiovascular responses, neuro-muscular blocking properties and reversal characteristics of pipecuronium bromide and pancuronium bromide. This is a prospective hospital based study. 100 patients belonging to ASA grade I or II physical status aged 18 to 70 years were divided into two groups of 50 patients each. Group 1 received pipecuronium bromide in the dose of .08 mg / kg and group 2 patients received pancuronium bromide in dose of 0.1 mg/kg. Each patient was pre medicated uniformly. Time for onset of apnoea for pipecuronium and pancuronium were 91.64+ 3.59 sec. and 118.84 + 12.53 sec. respectively. The mean time for intubation was 126.60 +12.55 sec. and 144.60 + 22.87 sec. with pipecuronium and pancuronium respectively. Mean duration of block for pipecuronium was 78.64 + 8.97 min. the block for pancuronium lasted from +36-40 min with a mean duration of block 41.60+ 5.57 min. The mean duration of maintenance dose in pipecuronium cases was 45.08 + 7.19 min., while it was 27.06 + 5.01 min in pancuronium cases. -
Pancuronium Bromide (Pavulon | Evaluation of Its Clinical Pharmacology*
PANCURONIUM BROMIDE (PAVULON | EVALUATION OF ITS CLINICAL PHARMACOLOGY* ALLEN B. DOBKIN, M.D., WILLIAM EVEBS,M.D., SION GHANOONI, M.D., ASHLEYA. LEVY, VH.D., AND EDWARDT. THOMAS,M.B. PANCURONIUMBROMIDE IS AN amino steroid muscle relaxant (Figure 1) which was synthesized in 1964 by Hewett and Savage and has been studied and evaluated clinically in Europe during the past four years2-5 It is an odourless, white, crystal- line powder with a bitter astringent taste, melts at 215~ with decomposition, and is soluble in 50 parts of chloroform and one part water at 20~ The co]ourless solution is stable while sealed, but breaks down in a few hours after exposure to air. In Europe it is available in 2-ml ampoules containing 4 mg pancuronium bro- mide, 18 nag sodium chloride B.P. and water for injection B.P. to 2 mls. The prepara- tion which was used in this study contains preservatives (acetic acid and sodium acetate) to buffer the solution to pH 4.0. OOC.CH 3N~~ 2BP- CH3CO0 H H20 -- Pancur'ontum Bromide - Pavuton (R) FIGURE 1. Structural formula for paneuronium bromide - Pavulon| Pharmacological studies have shown that it has no hormonal action but is a potent non-depolarizing skeletal muscle relaxant like'tubocurarine and gallamine. It has a more rapid onset of action than tubocurarine with a similar duration of action. It has a somewhat longer action than gallamine. It has no significant effect on the blood pressure or the tracheobronchial tree due to the very. slight ganglion- blocking action and the claim is that no histamine is released, a It does not affect *From the Department of Anesthesiology, State University Itospital, State University of New York, Upstate Medical Center, Syracuse, New York, 13210, U.S.A. -
Gy Total Body Irradiation Followed by Allogeneic Hematopoietic St
Bone Marrow Transplantation (2009) 44, 785–792 & 2009 Macmillan Publishers Limited All rights reserved 0268-3369/09 $32.00 www.nature.com/bmt ORIGINAL ARTICLE Fludarabine, amsacrine, high-dose cytarabine and 12 Gy total body irradiation followed by allogeneic hematopoietic stem cell transplantation is effective in patients with relapsed or high-risk acute lymphoblastic leukemia F Zohren, A Czibere, I Bruns, R Fenk, T Schroeder, T Gra¨f, R Haas and G Kobbe Department of Haematology, Oncology and Clinical Immunology, Heinrich Heine-University, Du¨sseldorf, Germany In this prospective study, we examined the toxicity and Introduction efficacy of an intensified conditioning regimen for treatment of patients with relapsed or high-risk acute The use of intensified conventional induction chemothera- lymphoblastic leukemia who undergo allogeneic hemato- pies in the treatment of newly diagnosed ALL in adult poietic stem cell transplantation. Fifteen patients received patients has led to initial CR rates of up to 90%. But, as fludarabine 30 mg/m2, cytarabine 2000 mg/m2, amsacrine some patients are even refractory to first-line therapy, the 100 mg/m2 on days -10, -9, -8 and -7, anti-thymocyte majority of the responding patients unfortunately suffer globulin (ATG-Fresenius) 20 mg/kg body weight on days from relapse. Therefore, the probability of long-term -6, -5 and -4 and fractionated total body irradiation disease-free survival is o30%.1–5 Risk stratification based 2 Â 2 Gy on days -3, -2 and -1 (FLAMSA-ATG-TBI) on prognostic factors allows identification of high-risk before allogeneic hematopoietic stem cell transplantation. ALL patients with poor prognosis.6–12 Myeloablative At the time of hematopoietic stem cell transplantation, 10 conditioning therapy followed by allogeneic hematopoietic patients were in complete remission (8 CR1; 2 CR2), 3 stem cell transplantation (HSCT) is currently the treatment with primary refractory and 2 suffered from refractory of choice for these high-risk patients.13–15 A combination of relapse. -
Comparative Study of Different Doses of Rocuronium Bromide For
MedDocs Publishers Annals of Anesthesia and Pain Medicine Open Access | Research Article Comparative study of different doses of rocuronium bromide for endotracheal intubation Nidhi V Sardhara1*; Sonal A Shah2; Dhaval P Pipaliya3; Shivansh Gupta3 1SVP hospital, 13th floor, Room no 13125, Near Ellis bridge, Ahmedabad, Gujarat-380006 2Assistant Professor, Department of anesthesia, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India 3First year Resident, Department of anesthesia, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India *Corresponding Author(s): Nidhi V Sardhara Abstract SVP hospital, 13th floor, Room no 13125, Near Ellis Background: Endotracheal intubation is one of such bridge, Ahmedabad, Gujarat-380006 development without which general anesthesia cannot be Tel: +91-9428-44-7878, Fax: 7926-57-8452 considered safe for any major surgery particularly head and Email: [email protected] neck, thoracic and abdominal surgeries. Ever since the ad- vent of anesthesia, anesthesiologists have been in search of an ideal muscle relaxants which can provide ideal intu- bating conditions in ultrashort duration with minimal side effects. Rocuronium bromide provides fast onset of action, Received: Mar 11, 2020 an intermediate duration of action and rapid recovery, good Accepted: Apr 24, 2020 to excellent intubating conditions at doses having minimal Published Online: Apr 30, 2020 or no haemodynamic changes. Present study is to compare the effect of different doses (0.6 mg/kg, 0.9 mg/kg, 1.2 mg/ Journal: Annals of Anesthesia and Pain Medicine kg) of Rocuronium bromide for endotracheal intubation at Publisher: MedDocs Publishers LLC 60 seconds. Online edition: http://meddocsonline.org/ Material and methods: This study was carried out by Copyright: © Sardhara NV (2020). -
United States Patent (10) Patent No.: US 8,969,514 B2 Shailubhai (45) Date of Patent: Mar
USOO896.9514B2 (12) United States Patent (10) Patent No.: US 8,969,514 B2 Shailubhai (45) Date of Patent: Mar. 3, 2015 (54) AGONISTS OF GUANYLATECYCLASE 5,879.656 A 3, 1999 Waldman USEFUL FOR THE TREATMENT OF 36; A 6. 3: Watts tal HYPERCHOLESTEROLEMIA, 6,060,037- W - A 5, 2000 Waldmlegand et al. ATHEROSCLEROSIS, CORONARY HEART 6,235,782 B1 5/2001 NEW et al. DISEASE, GALLSTONE, OBESITY AND 7,041,786 B2 * 5/2006 Shailubhai et al. ........... 530.317 OTHER CARDOVASCULAR DISEASES 2002fOO78683 A1 6/2002 Katayama et al. 2002/O12817.6 A1 9/2002 Forssmann et al. (75) Inventor: Kunwar Shailubhai, Audubon, PA (US) 2003,2002/0143015 OO73628 A1 10/20024, 2003 ShaubhaiFryburg et al. 2005, OO16244 A1 1/2005 H 11 (73) Assignee: Synergy Pharmaceuticals, Inc., New 2005, OO32684 A1 2/2005 Syer York, NY (US) 2005/0267.197 A1 12/2005 Berlin 2006, OO86653 A1 4, 2006 St. Germain (*) Notice: Subject to any disclaimer, the term of this 299;s: A. 299; NS et al. patent is extended or adjusted under 35 2008/0137318 A1 6/2008 Rangarajetal.O U.S.C. 154(b) by 742 days. 2008. O151257 A1 6/2008 Yasuda et al. 2012/O196797 A1 8, 2012 Currie et al. (21) Appl. No.: 12/630,654 FOREIGN PATENT DOCUMENTS (22) Filed: Dec. 3, 2009 DE 19744O27 4f1999 (65) Prior Publication Data WO WO-8805306 T 1988 WO WO99,26567 A1 6, 1999 US 2010/O152118A1 Jun. 17, 2010 WO WO-0 125266 A1 4, 2001 WO WO-02062369 A2 8, 2002 Related U.S. -
CK0403, a 9‑Aminoacridine, Is a Potent Anti‑Cancer Agent in Human Breast Cancer Cells
MOLECULAR MEDICINE REPORTS 13: 933-938, 2016 CK0403, a 9‑aminoacridine, is a potent anti‑cancer agent in human breast cancer cells YUAN-WAN SUN1, KUEN-YUAN CHEN2, CHUL-HOON KWON3 and KUN-MING CHEN1 1Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA; 2Department of Surgery, National Taiwan University Hospital, Taipei 8862, Taiwan, R.O.C.; 3Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, New York, NY 11439, USA Received November 11, 2014; Accepted October 22, 2015 DOI: 10.3892/mmr.2015.4604 Abstract. 3-({4-[4-(Acridin-9-ylamino)phenylthio]phenyl} reduced growth inhibitory activity under hypoxic conditions, (3-hydroxypropyl)amino)propan-1-ol (CK0403) is a which can induce autophagy. Collectively, the present results sulfur-containing 9-anilinoacridine analogue of amsacrine and supported that CK0403 is highly potent and more effective than was found to be more potent than its analogue 2-({4-[4-(acridin- CK0402 against estrogen receptor-negative and 9-ylamino)phenylthio]phenyl}(2-hydroxyethyl)amino) HER2-overexpressing breast cancer cell lines, suggesting its ethan-1-ol (CK0402) and amsacrine in the inhibition of the future application for chemotherapy in breast cancer. topoisomerase II-catalyzed decatenation reaction. A previous study by our group reported that CK0402 was effective against Introduction numerous breast cancer cell lines, and the combination of CK0402 with herceptin enhanced its activity in HER2(+) Breast cancer is the most common type of cancer diagnosed SKBR-3 cells. In order to identify novel chemotherapeutic agents in American women and is the second most common cause with enhanced potency, the present study explored the potential of cancer-associated mortality. -
Vecuronium Bromide As Control
A COMPARATIVE STUDY TO FIND AN IDEAL INTUBATING DOSE OF INJ. ROCURONIUM BROMIDE USING INJ. VECURONIUM BROMIDE AS CONTROL. Dissertation submitted In partial fulfillment for the award of M.D DEGREE EXAMINATION M.D. ANAESTHESIOLOGY & CRITICAL CARE BRANCH X GOVT KILPAUK MEDICAL COLLEGE AND HOSPITAL SUBMITTED TO THE TAMILNADU DR. MGR MEDICAL UNIVERSITY CHENNAI APRIL – 2011 1 DECLARATION I, Dr. D.Shunmuga Priya, solemnly declare that the dissertation, “A COMPARATIVE STUDY TO FIND AN IDEAL INTUBATING DOSE OF INJ. ROCURONIUM BROMIDE USING INJ. VECURONIUM BROMIDE AS CONTROL” is a bonafide work done by me in the Department of Anaesthesiology and Critical Care, Government Kilpauk, Medical College, Chennai under the able guidance of Prof. Dr. P.S. Shanmugam, MD., DA., Professor and HOD, Department of Anaesthesiology and Critical Care, Government Kilpauk Medical College, Chennai. Place : Chennai Date : (Dr. D.SHUNMUGA PRIYA) 5 CERTIFICATE This is to certify that this dissertation titled “A COMPARATIVE STUDY TO FIND AN IDEAL INTUBATING DOSE OF INJ. ROCURONIUM BROMIDE USING INJ. VECURONIUM BROMIDE AS CONTROL” has been prepared by Dr. D.SHUNMUGA PRIYA under my supervision in the Department of Anaesthesiology and Critical Care, Government Kilpauk Medical College, Chennai during the academic period 2008-2011 and is being submitted to the Tamil Nadu Dr. M.G.R. Medical University, Chennai in partial fulfillment of the University regulation for the award of the Degree of Doctor of Medicine (MD Anaesthesiology and Critical Care) and her dissertation is a bonafide work. Prof..Dr. V.Kanagasabai, M.D Prof. Dr. P.S.Shanmugam, M.D., D.A. DEAN Professor & HOD, Government Kilpauk Medical College Department of Anaesthesiology and & Hospital, Critical Care, Chennai. -
Minocycline-Minocin-Fact-Sheet.Pdf
Minocycline PATIENT FACT SHEET (Minocin) Minocycline (minocin) is an anti-inflammatory antibiotic sometimes used to treat mild rheumatoid arthritis (RA). It belongs to the group of antibiotics, called tetracycline, which are typically used to treat infections. Although RA is not thought to be caused by an infection, minocycline may improve the signs and symptoms of this disease. Because it has been studied less and may be less effective than other options, it is not as commonly prescribed in RA. WHAT IS IT? Minocycline is usually taken as a 100 mg capsule twice a day. It may be taken with food but should not be taken with other medications such as antacids or iron tablets. It has a slow onset and may take several months to work. HOW TO TAKE IT The most common side effects from this medicine rare cases, minocycline can cause drug-induced lupus, are gastrointestinal upset, dizziness, and skin rash. but this condition usually improves after stopping Patients who take this medication for a long time may the medication. notice changes in their skin color, but this usually Minocycline is passed into breast milk, so mothers resolves after stopping the medication. Some women should avoid breast-feeding in order to prevent delayed who take minocycline develop vaginal yeast infections. development of teeth and bones in their infants. Minocycline may increase sensitivity to sunlight, resulting Minocycline can increase a nursing infant’s risk of fungal in more frequent sunburns or the development of rashes infections or dizziness. Because minocycline may cause SIDE following sun exposure. Avoiding prolonged sun exposure discoloration of teeth and problems with bone growth in and sunscreen is recommended. -
Delayed Dosing of Minocycline Plus N-Acetylcysteine Reduces Neurodegeneration in Distal Brain Regions and Restores Spatial Memor
Manuscript bioRxiv preprint doi: https://doi.org/10.1101/2021.03.28.437090; this version posted March 29, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Delayed dosing of minocycline plus N-acetylcysteine reduces neurodegeneration in distal brain regions and restores spatial memory after experimental traumatic brain injury Kristen Whitney 1,2, Elena Nikulina1, Syed N. Rahman1, Alisia Alexis1 and Peter J. Bergold1,2 1Department of Physiology and Pharmacology 2Program in Neural and Behavioral Science, School of Graduate Studies State University of New York-Downstate Health Sciences University, Brooklyn NY 11215 Corresponding Author: [email protected] Department of Physiology and Pharmacology, Box 29 State University of New York – Downstate Health Sciences University 450 Clarkson Avenue Brooklyn, NY 11215 Declarations of interest: none Abbreviations: CHI- closed head injury Contra- contralateral Ipsi- ipsilateral MAP2 -microtubule associated protein 2 MINO- minocycline MN12- MINO plus NAC first dosed 12 hours after injury MN72- MINO plus NAC first dosed 72 hours after injury NAC- N-acetylcysteine TBI- Traumatic brain injury 1 bioRxiv preprint doi: https://doi.org/10.1101/2021.03.28.437090; this version posted March 29, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Abstract Multiple drugs to treat traumatic brain injury (TBI) have failed clinical trials. Most drugs lose efficacy as the time interval increases between injury and treatment onset. Insufficient therapeutic time window is a major reason underlying failure in clinical trials. -
A Critical Study on Chemistry and Distribution of Phenolic Compounds in Plants, and Their Role in Human Health
IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT) e-ISSN: 2319-2402,p- ISSN: 2319-2399. Volume. 1 Issue. 3, PP 57-60 www.iosrjournals.org A Critical Study on Chemistry and Distribution of Phenolic Compounds in Plants, and Their Role in Human Health Nisreen Husain1, Sunita Gupta2 1 (Department of Zoology, Govt. Dr. W.W. Patankar Girls’ PG. College, Durg (C.G.) 491001,India) email - [email protected] 2 (Department of Chemistry, Govt. Dr. W.W. Patankar Girls’ PG. College, Durg (C.G.) 491001,India) email - [email protected] Abstract: Phytochemicals are the secondary metabolites synthesized in different parts of the plants. They have the remarkable ability to influence various body processes and functions. So they are taken in the form of food supplements, tonics, dietary plants and medicines. Such natural products of the plants attribute to their therapeutic and medicinal values. Phenolic compounds are the most important group of bioactive constituents of the medicinal plants and human diet. Some of the important ones are simple phenols, phenolic acids, flavonoids and phenyl-propanoids. They act as antioxidants and free radical scavengers, and hence function to decrease oxidative stress and their harmful effects. Thus, phenols help in prevention and control of many dreadful diseases and early ageing. Phenols are also responsible for anti-inflammatory, anti-biotic and anti- septic properties. The unique molecular structure of these phytochemicals, with specific position of hydroxyl groups, owes to their powerful bioactivities. The present work reviews the critical study on the chemistry, distribution and role of some phenolic compounds in promoting health-benefits. -
BC Cancer Benefit Drug List September 2021
Page 1 of 65 BC Cancer Benefit Drug List September 2021 DEFINITIONS Class I Reimbursed for active cancer or approved treatment or approved indication only. Reimbursed for approved indications only. Completion of the BC Cancer Compassionate Access Program Application (formerly Undesignated Indication Form) is necessary to Restricted Funding (R) provide the appropriate clinical information for each patient. NOTES 1. BC Cancer will reimburse, to the Communities Oncology Network hospital pharmacy, the actual acquisition cost of a Benefit Drug, up to the maximum price as determined by BC Cancer, based on the current brand and contract price. Please contact the OSCAR Hotline at 1-888-355-0355 if more information is required. 2. Not Otherwise Specified (NOS) code only applicable to Class I drugs where indicated. 3. Intrahepatic use of chemotherapy drugs is not reimbursable unless specified. 4. For queries regarding other indications not specified, please contact the BC Cancer Compassionate Access Program Office at 604.877.6000 x 6277 or [email protected] DOSAGE TUMOUR PROTOCOL DRUG APPROVED INDICATIONS CLASS NOTES FORM SITE CODES Therapy for Metastatic Castration-Sensitive Prostate Cancer using abiraterone tablet Genitourinary UGUMCSPABI* R Abiraterone and Prednisone Palliative Therapy for Metastatic Castration Resistant Prostate Cancer abiraterone tablet Genitourinary UGUPABI R Using Abiraterone and prednisone acitretin capsule Lymphoma reversal of early dysplastic and neoplastic stem changes LYNOS I first-line treatment of epidermal