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List of Drugs to Be Avoided by Patients with Congenital Long QT Syndrome

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List of Drugs to Be Avoided by Patients with Congenital Long QT Syndrome BC INHERITED St. Paul’s Hospital (Vancouver) Royal Jubilee Hospital (Victoria) Northern Outreach Clinic (Hazelton) ARRHYTHMIA Ph: 604-682-2344 Ext. 66766 Ph: 250-727-4461 Ph: 250-727-4461 PROGRAM List of Drugs to be Avoided by Patients with Congenital Long QT Syndrome (LQTS)* updated July 2013 *This list is not comprehensive but is meant to be a practical list for those clinicians managing patients with LQTS in Canada. Patients with LQTS should discuss ALL new medications (prescription and over the counter) with their health care provider Drugs with ABSOLUTE Drugs with RELATIVE/THEORETICAL CONTRAINDICATION CONTRAINDICATION PRESCRIPTION DRUGS PRESCRIPTION DRUGS Amiodarone Alfuzosin (Xatrol) Metoclopramide Amitriptyline (Elavil) Amantadine Midodrine Azithromycin (Zithromax) Aripiprazole (Abilify) Mirtazapine (Remeron) Chloroquine (Aralen) Atazanavir (Reyataz) Nilotinib (Tasigna) Chlorpromazine Atomoxetine (Stattera) Norepinephrine Bretylium Citalopram (Celexa) Norfloxacin Buprenorphine (BuTrans 5, 10, 20 and in Clarithromycin Octreotide (Sandostatin) Suboxone) Clomipramine Olanzapine (Zyprexa) Chloral hydrate Desipramine Ofloxacin Ciprofloxacin Disopyramide (Rythmodan) Orciprenaline Clozapine Dolasetron (Anzemet) Orphenadrine (Norflex) Cyclobenzaprine, theoretical Domperidone Oxycodone ( OxyNEO and in Oxycocet) Cyclosporin (Neoral) Doxepin Oxytocin Dasatinib (Sprycel) Dronedarone (Multaq) Paliperidone (Invega) Degarelix (Firmagon) Droperidol Paroxetine (Paxil) Desvenlafaxine (Pristiq) Erythromycin Papaverine Dextroamphetamine Escitalopram (Cipralex) Pazopanib (Votrient) (Dexedrine and in Adderall) Flecainide (Tambocor) Perflutren lipid microspheres (Definity) Dobutamine Haloperidol (Haldol) Perphenazine Donepezil (Aricept) Ibutilide (Corvert) Posaconazole (Posanol) Dopamine Imipramine Promethazine Ephedrine Maprotiline Quinine Fingolimod (Gilenya) Methadone (Metadol) Risperidone (Risperdal) Fluconazole Mexiletine Ritonavir (Norvir) Fluoxetine (Prozac) Moxifloxacin (Avelox) Ritonavir / Lopinavir (Kaletra) Formoterol (Oxeze Turbuhaler and in Nortriptyline Salbutamol (Ventolin) Symbicort), theoretical Ondansetron (Zofran) Salmeterol (Serevent and in Advair) Fosphenytoin (Cerebyx) Pentamidine Sertraline (Zoloft) Galantamine (Reminyl) Pimozide Solifenacin (Vesicare) Gatifloxacin (Tequin) Procainamide Sorafenib (Nexavar) Granisetron (Kytril) Propafenone (Rythmol) Spiramycin (Rovamycine) Hydroxychloroquine (Plaquenil) Propoxyphene Sunitinib (Sutent) Hydroxyzine Quetiapine (Seroquel) Tacrolimus (Prograf, Protopic) Indapamide (Lozide and in Coversyl Plus) Quinidine Tamoxifen Isoproterenol Saquinavir (Invirase) Terbutaline (Bricanyl Turbuhaler) Itraconazole (Sporanox) Sotalol Thiothixene (Navane) Ketoconazole (Nizoral) Trazodone Tizanidine (Zanaflex) Lapatinib (Tykerb) Trimipramine Tolterodine (Detrol) Levofloxacin (Levaquin) Vandetanib (Caprelsa) Trimethoprim / Sulfamethoxazole (Septra) Lisdexamfetamine (Vyvanse) Ziprasidone (Zeldox) Vardenafil (Levitra) Lithium (Carbolith) Venlafaxine (Effexor) Mefloquine (Larium) Voriconazole (VFend) Methylphenidate (Ritalin, Concerta) Vorinostat (Zolinza) Drugs with RELATIVE/THEORETICAL CONTRAINDICATION (continued) OVER-THE-COUNTER DRUGS Cetirizine (Reactine), minor Ginseng (Cold – FX) Phenylephrine (Sudafed PE and in Diphenhydramine (Benadryl), minor Loratidine (Claritin), theoretical combination Decongestants) Epinephrine (EpiPen, Twinject) (no reports) Pseudoephedrine (Sudafed and in Famotidine (Pepcid) combination Decongestants) STREET DRUGS Amphetamine (bennies, speed, uppers) Methylenedioxy-methamphetamine or MDMA (E, ecstasy, MDA, X) Cocaine (blow, C, coke, crack, rock, snow) Oxycodone (killers, OCs, oxycotton, oxys) Methamphetamine (chalk, crystal meth, ice, meth), Quetiapine (baby heroin, Suzie-Q) [mixed with other drugs] .
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