RESEARCH Efficacy of recommended drugs against soil transmitted BMJ: first published as 10.1136/bmj.j4307 on 25 September 2017. Downloaded from helminths: systematic review and network meta-analysis Wendelin Moser,1,2 Christian Schindler,2,3 Jennifer Keiser1,2 1Department of Medical ABSTRACT 43.4% (23.5% to 63.3%; P=0.049) and the cure rates Parasitology and Infection OBJECTIVE fell from 38.6% (26.2% to 52.7%) to 16.4 (7.7% to Biology, Swiss Tropical and To evaluate efficacies of anthelmintic drugs against 31.3%; P=0.027). Public Health Institute, PO Box, CH-4002 Basel, Switzerland soil transmitted helminths in terms of cure rates and CONCLUSIONS 2University of Basel, Basel, egg reduction rates. All four currently recommended drugs show Switzerland DESIGN limitations in their efficacy profile. While only 3 Department of Epidemiology Systematic review and network meta-analysis. albendazole showed good efficacy against hookworm and Public Health, Swiss Tropical and Public Health DATA SOURCES infection, all drugs had low efficacy againstT trichiura. Institute, PO Box, CH-4002 PubMed, ISI Web of Science, Embase, ScienceDirect, The decrease in efficacy of albendazole againstT Basel, Switzerland the Cochrane Central Register of Clinical Trials, and the trichiura over the past two decades is of concern. The Correspondence to: J Keiser findings indicate the need for strengthening efforts to
[email protected] World Health Organization library database from 1960 until 31 December 2016. develop new drug treatments, with a particular focus Additional material is published on drugs against T trichiura. online only. To view please visit STUDY SELECTION the journal online.