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Efficacy of Recommended Drugs Against Soil Transmitted Helminths
RESEARCH Efficacy of recommended drugs against soil transmitted BMJ: first published as 10.1136/bmj.j4307 on 25 September 2017. Downloaded from helminths: systematic review and network meta-analysis Wendelin Moser,1,2 Christian Schindler,2,3 Jennifer Keiser1,2 1Department of Medical ABSTRACT 43.4% (23.5% to 63.3%; P=0.049) and the cure rates Parasitology and Infection OBJECTIVE fell from 38.6% (26.2% to 52.7%) to 16.4 (7.7% to Biology, Swiss Tropical and To evaluate efficacies of anthelmintic drugs against 31.3%; P=0.027). Public Health Institute, PO Box, CH-4002 Basel, Switzerland soil transmitted helminths in terms of cure rates and CONCLUSIONS 2University of Basel, Basel, egg reduction rates. All four currently recommended drugs show Switzerland DESIGN limitations in their efficacy profile. While only 3 Department of Epidemiology Systematic review and network meta-analysis. albendazole showed good efficacy against hookworm and Public Health, Swiss Tropical and Public Health DATA SOURCES infection, all drugs had low efficacy againstT trichiura. Institute, PO Box, CH-4002 PubMed, ISI Web of Science, Embase, ScienceDirect, The decrease in efficacy of albendazole againstT Basel, Switzerland the Cochrane Central Register of Clinical Trials, and the trichiura over the past two decades is of concern. The Correspondence to: J Keiser findings indicate the need for strengthening efforts to [email protected] World Health Organization library database from 1960 until 31 December 2016. develop new drug treatments, with a particular focus Additional material is published on drugs against T trichiura. online only. To view please visit STUDY SELECTION the journal online. -
Vitamin and Mineral Supplements
Page 1 of 2 Vitamin and Mineral Supplements After Weight-Loss Surgery You will need to take extra vitamins and minerals Take them at bedtime, if you wish. Do not take for the rest of your life. You can buy these vitamins them within two hours of your calcium supplement. and minerals at your local drug store. Start with a chewable or liquid form. You may switch If you have problems finding them or your body to whole tablets when your body can handle them. cannot handle them, call the nurse line. Vitamin D Multi-vitamin with minerals Take an extra 2000 IU (international units) Your complete multi-vitamin with minerals should of vitamin D each day. You may take it with have all of the following: your calcium. • at least 18 mg of iron Adjustable gastric band: take 3000 IU each day. • at least 400 mcg of folic acid • at least 2 mg of copper Calcium • at least 1.5 mg of thiamin Take 1200 to 1500 mg of calcium each day. Choose one type: Adjustable gastric band: take 500 to 600 mg. ☐ Children’s complete chewable multi-vitamin Choose a brand that includes vitamin D. Calcium with minerals. Each day, take twice the adult citrate is best. If you cannot find this, take calcium dose listed on the label. carbonate instead. OR . • If you take calcium carbonate, take it with food. ☐ Adult complete multi-vitamin with minerals. Take two tablets each day. • Take no more than 500 to 600 mg of calcium at one time. Your body can only take in this amount Note: if you have an adjustable gastric band, take at once. -
Calcium Supplements | Memorial Sloan Kettering Cancer Center
PATIENT & CAREGIVER EDUCATION Calcium Supplements This information explains calcium supplements and how to take them. Calcium is a mineral that you need to build and maintain healthy bones. If you don’t get enough calcium from your diet, your body will take it from your bones. This can cause osteoporosis. Osteoporosis Osteoporosis develops when you lose bone tissue, which makes your bones more likely to fracture (break). Osteoporosis is most common in females who have gone through menopause (a permanent end of your monthly periods). It can develop in anyone, including males, due to medication or illness. Some risk factors for osteoporosis include: Having a thin build Being of Northern European or Asian descent Having fair skin Going through menopause early (before the age of 45) Taking certain steroid medications for longer than 3 months Calcium Supplements 1/9 Not getting enough physical activity Not getting enough calcium in your diet (or from dietary supplements) Smoking Drinking too much alcohol (more than 2 drinks per day for females or 3 drinks per day for males) Taking aromatase inhibitors (medications that stop the production of estrogen and are used to treat breast cancer) Vitamin D Vitamin D is a vitamin that helps your body absorb calcium. Your body makes vitamin D after being exposed to the sun. Vitamin D is also found in some foods. It can be hard to get enough vitamin D from just sunlight and foods. Your doctor or clinical dietitian nutritionist might tell you to take vitamin D supplements. These can be prescription or over-the-counter vitamin D supplement pills or calcium supplements with vitamin D added. -
Calcium Supplement Safety Fact Sheet
CALCIUM SUPPLEMENT SAFETY FACT SHEET How much calcium do you need daily?2 38% of Total amount of calcium from food and supplements, by age and gender. Americans don’t meet 1,000 1,200 1,000 1,200 mg mg mg mg recommended 70 & YOUNGER 71 & OLDER 50 & YOUNGER 51 & OLDER intakes for MEN WOMEN calcium.1 Calcium absorption is as high as 60% in infants Your body’s ability to absorb and young children, who calcium decreases as need substantial amounts to build bone. calcium intake increases. Absorption decreases to 15-20% in Adults only absorb about 500-600 mg adulthood and continues to decrease as of calcium at once, so its best to take people age. This is why recommended supplements in smaller doses with food. intakes are higher for older individuals. More than 99% of the body’s calcium resides in the bones and teeth.2 Consuming adequate calcium is important in building strong bones in younger individuals and protecting bones as we age. If you don’t get enough calcium from the diet your body pulls it out of your bones to compensate. SOURCES: 1. Fulgoni VL, Keast DR, Bailey RL et al. Foods, Fortificants, and Supplements: Where Do Americans Get Their Nutrients? J Nutr 2011; 141:1847-54. 2. http://nof.org/calcium. 3. U.S. Department of Agriculture, Agricultural Research Service. 2012. USDA National Nutrient Database for Standard Reference, Release 25. Nutrient Data Laboratory Home Page, http://www.ars.usda.gov/ba/bhnrc/ndl. 4. Weaver CM Calcium Supplementation: Is protecting against osteoporosis counter to protecting against cardiovascular disease? Curr Osteoporos Rep. -
Vitamin and Mineral Requirements in Human Nutrition
P000i-00xx 3/12/05 8:54 PM Page i Vitamin and mineral requirements in human nutrition Second edition VITPR 3/12/05 16:50 Page ii WHO Library Cataloguing-in-Publication Data Joint FAO/WHO Expert Consultation on Human Vitamin and Mineral Requirements (1998 : Bangkok, Thailand). Vitamin and mineral requirements in human nutrition : report of a joint FAO/WHO expert consultation, Bangkok, Thailand, 21–30 September 1998. 1.Vitamins — standards 2.Micronutrients — standards 3.Trace elements — standards 4.Deficiency diseases — diet therapy 5.Nutritional requirements I.Title. ISBN 92 4 154612 3 (LC/NLM Classification: QU 145) © World Health Organization and Food and Agriculture Organization of the United Nations 2004 All rights reserved. Publications of the World Health Organization can be obtained from Market- ing and Dissemination, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel: +41 22 791 2476; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permis- sion to reproduce or translate WHO publications — whether for sale or for noncommercial distri- bution — should be addressed to Publications, at the above address (fax: +41 22 791 4806; e-mail: [email protected]), or to Chief, Publishing and Multimedia Service, Information Division, Food and Agriculture Organization of the United Nations, 00100 Rome, Italy. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization and the Food and Agriculture Organization of the United Nations concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. -
Healthy Aging Supplement Guide
Examine.com Healthy Aging Supplement Guide Written by Michael Hull, MSc, and Wyatt Brown Edited by Pierre-Alexandre Sicart, PhD Reviewed by Kamal Patel, MPH, MBA, PhD(c), and the Examine.com team Updated April 2020 Table of Contents Medical Disclaimer How to Use This Guide Combos Core Supplements Primary Options Secondary Options Unproven Supplements Inadvisable Supplements FAQ References Bios 2 Medical Disclaimer This guide is a general-health document for adults 18 or over. Its aim is strictly educational. It does not constitute medical advice. Please consult a medical or health professional before you begin any exercise-, nutrition-, or supplementation-related program, or if you have questions about your health. This guide is based on scientific studies, but individual results do vary. If you engage in any activity or take any product mentioned herein, you do so of your own free will, and you knowingly and voluntarily accept the risks. While we mention major known interactions, it is possible for any supplement to interact with other supplements, with foods and pharmaceuticals, and with particular health conditions. 3 How to Use This Guide The Examine.com team has been publishing research on nutrition and supplementation since March 2011. Drawing from all we’ve learned, we’ve designed this Supplement Guide with two aims in mind: helping you decide which supplements are right for you, based on the scientific evidence, and helping you integrate these supplements into synergistic combos. Core supplements have the best safety-efficacy profile. When used responsibly, they are the supplements most likely to help and not cause side effects. -
Review Article a BRIEF REVIEW on the MODE of ACTION of ANTINEMATODAL DRUGS
Acta Veterinaria-Beograd 2017, 67 (2), 137-152 UDK: 615.284.03 DOI: 10.1515/acve-2017-0013 Review article A BRIEF REVIEW ON THE MODE OF ACTION OF ANTINEMATODAL DRUGS ABONGWA Melanie, MARTIN Richard J., ROBERTSON Alan P.* Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA (Received 01 May, Accepted 24 May 2017) Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites. Key words: anthelmintic, parasite, benzimidazoles, avermectins, cholinergic, emodepside, derquantel INTRODUCTION Anthelmintics are drugs that are used to treat infections caused by parasitic worms (helminths) [1]. There are three major groups of helminths namely: nematodes (roundworms), trematodes (fl ukes) and cestodes (tapeworms). These groups of helminths are divided into two phyla; nematodes (roundworms) and platyhelminths (trematodes and cestodes) [2]. Anthelmintics either kill worms or cause their expulsion from the body, without causing any signifi cant damage to the host [3]. -
WSAVA List of Essential Medicines for Cats and Dogs
The World Small Animal Veterinary Association (WSAVA) List of Essential Medicines for Cats and Dogs Version 1; January 20th, 2020 Members of the WSAVA Therapeutic Guidelines Group (TGG) Steagall PV, Pelligand L, Page SW, Bourgeois M, Weese S, Manigot G, Dublin D, Ferreira JP, Guardabassi L © 2020 WSAVA All Rights Reserved Contents Background ................................................................................................................................... 2 Definition ...................................................................................................................................... 2 Using the List of Essential Medicines ............................................................................................ 2 Criteria for selection of essential medicines ................................................................................. 3 Anaesthetic, analgesic, sedative and emergency drugs ............................................................... 4 Antimicrobial drugs ....................................................................................................................... 7 Antibacterial and antiprotozoal drugs ....................................................................................... 7 Systemic administration ........................................................................................................ 7 Topical administration ........................................................................................................... 9 Antifungal drugs ..................................................................................................................... -
Activity of Selected Antioxidative Enzymes in Rats Exposed to Dimethoate and Pyrantel Tartrate
Polish Journal of Veterinary Sciences Vol. 15, No. 2 (2012), 239-245 DOI 10.2478/v10181-011-0140-6 Original article Activity of selected antioxidative enzymes in rats exposed to dimethoate and pyrantel tartrate D. Barski, A. Spodniewska Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland Abstract This study presents the results of research concerning the effect of single and combined applica- tion of pyrantel tartrate and dimethoate on selected antioxidative enzymes: catalase (CAT), superox- ide dismutase (SOD) and glutathione peroxidase (GPx), in rat erythrocytes. Pyrantel tartrate was applied twice, at a dose of 85 mg/kg bw at a two week interval, i.e. on day 14 and 28 of the experiment, orally, in a water solution with a stomach tube. Dimethoate was administered with drinking water for 28 days at a dose of 25 mg/kg bw/day. It was found that pyrantel tartrate caused only small changes in the activity of the antioxidative enzymes under analysis. Subchronic exposure of rats to dimethoate caused a significant increase in the activity of CAT, SOD and GPx in erythrocytes, indicating the existence of strong oxidative stress. In combined intoxication, no significant effects of administering pyrantel tartrate on the activity of CAT, SOD and GPx was found in animals poisoned with dimethoate. The profile of changes was similar to that observed in rats exposed only to the or- ganophosphorus insecticide. This may indicate a lack of interaction between the compounds used in the experiment. Key words: dimethoate, pyrantel tartrate, rats, CAT, SOD, GPx Introduction and Wall 2008). -
Summary of Veterinary Care Guidelines for Otters in Zoos, Aquariums, Rehabilitation, and Wildlife Centers
IUCN/SSC Otter Specialist Otters in Zoos, Aquaria, Rehabilitation, and Wildlife Group Sanctuaries Task Force Summary of Veterinary Care Guidelines for Otters in Zoos, Aquariums, Rehabilitation, and Wildlife Centers G. Myers, DVM, Contributions by: K. Petrini, and J. Reed-Smith 2011 Published by: IUCN/SSC Otter Specialist Group’s, Otters in Zoos, Aquaria, Rehabilitation, and Wildlife Sanctuaries Task Force (OZ) http://www.otterspecialistgroup.org/Library/TaskForces/OCT.html Edited by: Jan Reed-Smith, Coordinator OZ Task Force Reviewed by: G. Kollias, DVM, PhD; H. Jacques, DVM; A. Günther-Weigl, DVM Photograph: N. A. river otter hind foot, J. Reed-Smith, John Ball Zoological Garden OSG/Otters in Zoos etc Task Force/Veterinary Care of Otters 2012 Page 1 IUCN/SSC Otter Specialist Otters in Zoos, Aquaria, Rehabilitation, and Wildlife Group Sanctuaries Task Force VETERINARY CARE Veterinary services are a vital component of excellent animal care practices. A full-time staff veterinarian is recommended for all types of wildlife facilities; however, in cases where this is not practical, a consulting/part-time veterinarian should be under contract. In these cases the contracted veterinarian should make at least twice monthly inspections of the animal collection and be available for any emergencies. Veterinary coverage also should be available so that any indications of disease, injury, or stress may be responded to in a timely manner. Protocols for the use and security of drugs used for veterinary purposes should be formally written and available to animal care staff. Procedures should include, but are not limited to: a list of persons authorized to administer animal drugs, situations in which they are to be utilized, location of animal drugs and those persons with access to them, and emergency procedures in the event of accidental human exposure to these drugs. -
Marine Mammal Pharmacology
27 PHARMACEUTICALS AND FORMULARIES CLAIRE A. SIMEONE AND MICHAEL K. STOSKOPF Contents Introduction Introduction .......................................................................... 593 This chapter aims to provide clinicians and scientists working Routes for Administering Drugs to Marine Mammals ......... 594 with marine mammals with a convenient and rapidly acces- Dose Scaling ......................................................................... 595 sible single source on the subject. A compilation of the avail- Drug Interactions and Adverse Effects ................................ 596 able pharmacological information on cetaceans, pinnipeds, Life-Threatening Adverse Reactions .................................... 596 sirenians, sea otters (Enhydra lutris), and polar bears (Ursus Hepatic Effects ...................................................................... 596 maritimus) is provided. Readers must be aware at all times Renal Effects ......................................................................... 597 that drugs discussed in this chapter may have only been Gastrointestinal Effects ......................................................... 597 used on a limited number of individual animals from a nar- Nervous System Effects ........................................................ 597 row range of species, so all information must be interpreted Dermal Effects ...................................................................... 598 with caution. No drugs have been licensed for use in marine Otic Effects ........................................................................... -
Feeding Amphibians and Cultures of Invertebrates
Feeding amphibians and Cultures of invertebrates Materials produced by: Gerardo Garcia, Durrell Background Amphibian nutritional requirements unknown Stomach contents best we have in most cases Few studied throughout the year, life time Incredible diversity of species Feeding Considerations • What will they eat? • Can I supply enough of the food item all year long? • How is the food going to be offered? Are they eating? • Hand feeding • Counting the food in and out • Presence of feces • Periodic massings Supply and Demand • Variety is the spice of life. • To culture or not to culture How is the food going to be offered? • Hand feeding • Broadcast feeding • Feeders Diet All adult amphibians are carnivores Larvae (tadpoles/efts) may be herbivorous, carnivorous, omnivorous or pass through one or more diet preferences throughout development Dietary items are mostly invertebrates of appropriate size but large species can consume vertebrates including other amphibians, reptiles, birds and small mammals Amphibians capture their prey with a sticky tongue or directly with their jaws and swallow their prey whole, often alive Food composition • Water • Protein • Carbohydrates • Fats • Minerals • Vitamins • Hormones • Toxins • Indigestible – chitin –fiber Water Carbohydrates • Important Nutrient Provide Energy • Makes food Palatable Digestible Sugars • Facilitates intestinal motility provide energy • Facilitates absorption of vitamins, sugars Indigestible Sugars Cellulose • Important to evaluate nutritional components Important to peristalsis in