bioRxiv preprint doi: https://doi.org/10.1101/2020.08.19.257162; this version posted August 20, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Centrosome amplification mediates small extracellular vesicles secretion via 4 lysosome disruption Sophie D. Adams1, Judit Csere1, Gisela D’angelo2, Edward P. Carter3, Teresa Arnandis1,4, Martin 8 Dodel1, Hemant Kocher3, Richard Grose3, Graça Raposo2, Faraz Mardakheh1 and Susana A. Godinho1,5,* 12 1 Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK 2 Structure and Membrane Compartments, Institute Curie, Paris Sciences & Lettres Research University, Centre for National de la Recherche Scientifique, UMR144, Paris, France 16 3 Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK 4 Current address: Department of Pathology, School of Medicine and Dentistry, Catholic University of Valencia, 46001, Valencia, Spain. 20 24 5 Lead Contact * Correspondence should be addressed to S.A.G.:
[email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.08.19.257162; this version posted August 20, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license.