AME Medical Review 2A011 Key Leaders’ Opinion on Immune and Exosome 2A011 immune and exosome and immune on Key opinion leaders’ www.amegroups.com Editors: Zhijun Han Theresa L. Whiteside Pietro Invernizzi Associate Editors: Mingzhu Gao Mingzhe Ning Editors: Zhijun Han Zhijun Editors: Tingwang Jiang Pietro Invernizzi Pietro L. Whiteside Theresa AME Medical Review 2A011 Key Leaders’ Opinion on Immune and Exosome Editors: Zhijun Han Theresa L. Whiteside Pietro Invernizzi Associate Editors: Mingzhu Gao Mingzhe Ning Tingwang Jiang Executive Editors: Cheng Chen, Xianfen Gao, Xiaowei Hu, Haohao Liu, Runqiu Xia, Aiyan Zhang AME Publishing Company Room C 16F, Kings Wing Plaza 1, NO. 3 on Kwan Street, Shatin, NT, Hong Kong Information on this title: www.amegroups.com For more information, contact [email protected] Copyright © AME Publishing Company. All rights reserved. This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of AME Publishing Company. First published in 2018 Printed in China by AME Publishing Company Editors: Zhijun Han, Theresa L. Whiteside, Pietro Invernizzi Cover Image Illustrator: Zhijing Xu, Shanghai, China Key Leaders’ Opinion on Immune and Exosome (Hard Cover) ISBN 978-988-78920-4-5 AME Publishing Company, Hong Kong AME Publishing Company has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. The advice and opinions expressed in this book are solely those of the authors and do not necessarily represent the views or practices of the publisher. No representation is made by the publisher about the suitability of the information contained in this book, and there is no consent, endorsement or recommendation provided by the publisher, express or implied, with regard to its contents. Key Leaders’ Opinion on Immune and Exosome I (FIRST EDITION) EDITORS Xianfen Gao Medical Technology Institute, Xuzhou Medical University, Zhijun Han Xuzhou, 221004 China Department of Laboratory Medicine, Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu, China Xiaowei Hu Department of Laboratory Medicine, The Affiliated Wuxi Theresa L. Whiteside No.2 People’s Hospital of Nanjing Medical University, Professor of Pathology, Immunology and Otolaryngology, Wuxi, 214002, China University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Suite Haohao Liu 1.32, Pittsburgh, PA 15213, USA Department of Laboratory Medicine, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Pietro Invernizzi Wuxi, 214002, China Associate Professor, Director, Program for Autoimmune Liver Diseases, International Center for Digestive Health, Runqiu Xia Department of Medicine and Surgery, University of Milan- Medical Technology Institute, Xuzhou Medical University, Bicocca, Via Cadore 48, 20900 Monza (MB), Italy Xuzhou, 221004 China Aiyan Zhang ASSOCIATE EDITORS Medical Technology Institute, Xuzhou Medical University, Xuzhou, 221004 China Mingzhu Gao Department of Laboratory Medicine, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, AUTHORS Wuxi, 214002, China Miguel Abal Mingzhe Ning Translational Medical Oncology, Health Research Institute Department of Laboratory Medicine, Nanjing Drum Tower of Santiago (IDIS), University Hospital of Santiago Hospital, Nanjing University Medical School, Nanjing, (SERGAS), Trav. Choupana s/n 15706 Santiago de 210008, China Compostela, Spain Tingwang Jiang Riccardo Alessandro Department of Key Laboratory and Microbiology, Biopathology and Biomedical Methodology, Biology and Institution of Laboratory Medicine of Changshu, Changshu Genetic Section, University of Palermo, Palermo, Italy 215500, China Giada Amodio San Raffaele Telethon Institute for Gene Therapy (SR- EXECUTIVE EDITORS Tiget), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scienti c Institute, Cheng Chen Milan, Italy Medical Technology Institute, Xuzhou Medical University, Xuzhou, 221004 China © AME Publishing Company. All rights reserved. www.amegroups.com II Hendrik Jan Ankersmit Guofeng Cheng Christian Doppler Laboratory for Cardiac and Thoracic Shanghai Veterinary Research Institute, Chinese Academy Diagnosis and Regeneration, Head FFG Project 852748 of Agricultural Sciences, Key Laboratory of Animal “APOSEC”, Department of Thoracic Surgery, Medical Parasitology, Ministry of Agriculture, Shanghai 200241, University Vienna, Vienna, Austria China Valentin Baloche Dimitry A. Chistiakov CNRS UMR8126, Gustave Roussy and Université Paris- Department of Molecular Genetic Diagnostics and Cell Sud/Paris-Saclay, 39 rue Camille Desmoulins, Villejuif, Biology, Division of Laboratory Medicine, Institute of France Pediatrics, Research Center for Children’s Health, Moscow, Russia Beverlie Baquir Department of Microbiology and Immunology, University Chi-Wing Chow of British Columbia, Vancouver, British Columbia, Canada Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA Lucian Beer Department of Biomedical Imaging and Image-guided Annalisa Contursi Therapy, Christian Doppler Laboratory for Cardiac and Department of Neuroscience, Imaging and Clinical Thoracic Diagnosis and Regeneration, Medical University Science, Section of Cardiovascular and Pharmacological Vienna, Vienna, Austria Sciences, CeSI-MeT (Centro Scienze dell’ Invecchiamento e Medicina Traslazionale), “G. d’Annunzio” University, Yuri V. Bobryshev Chieti, Italy Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia; Raquel Cortes School of Medicine, University of Western Sydney, Genomic and Genetic Diagnosis Unit, Research Group of Campbelltown, NSW, Australia Cardiometabolic and Renal Risk, INCLIVA Biomedical Research Institute, Accesorio 4, 46010 Valencia, Spain Pierre Busson CNRS UMR8126, Gustave Roussy and Université Paris- Hien Dang Sud/Paris-Saclay, 39 rue Camille Desmoulins, Villejuif, Laboratory of Human Carcinogenesis, National Cancer France Institute, Bethesda, MD 20892, USA Giovanni Camussi Eduardo de la Torre-Escudero Department of Medical Sciences, Molecular Biotechnology Institute for Global Food Security, School of Biological Center, University of Torino, Torino, Italy Sciences, Queen’s University Belfast, Belfast, Northern Ireland, UK Marco Carbone Program for Autoimmune Liver Diseases, International Boel De Paepe Center for Digestive Health, Department of Medicine and Neuromuscular Reference Center & Neurology Surgery, University of Milan- Bicocca, Milan, Italy Department, Ghent University Hospital, Ghent, Belgium Suzie Chen Pradip B. Devhare Susan Lehman Cullman Laboratory for Cancer Research, Department of Pathology, Saint Louis University, Saint Ernest Mario School of Pharmacy, Rutgers, Joint Graduate Louis, Missouri, USA Program in Toxicology, Rutgers, The State University, Piscataway, NJ, USA; Rutgers Cancer Institute of New Manuel Díaz-Llopis Jersey, New Brunswick, NJ, USA Departament de Cirurgia, Facultat de Medicina i Odontologia, Universitat de València, Valencia, Spain © AME Publishing Company. All rights reserved. www.amegroups.com III Farah Fatima Silvia Gregori Department of Pathology and Forensic Medicine, Ribeirão San Raffaele Telethon Institute for Gene Therapy (SR- Preto Medical School, University of São Paulo, São Paulo, Tiget), Division of Regenerative Medicine, Stem Cells and Brazil Gene Therapy, IRCCS San Raffaele Scienti c Institute, Milan, Italy Conor Feeley National Institute for Health Research-Leeds Robert E. W. Hancock Musculoskeletal Biomedical Research Unit (NIHR-LMBRU) Department of Microbiology and Immunology, University and Leeds Institute of Rheumatic and Musculoskeletal of British Columbia, Vancouver, British Columbia, Canada Medicine (LIRMM), Wellcome Trust Brenner Building, St James’s University Hospital, Leeds, UK Pietro Invernizzi Program for Autoimmune Liver Diseases, International Robin J. Flynn Center for Digestive Health, Department of Medicine and Department of Infection Biology, Institute of Infection and Surgery, University of Milan- Bicocca, Milan, Italy Global Health, University of Liverpool, Liverpool, UK Allison L. Isola Istvan Furi Susan Lehman Cullman Laboratory for Cancer Research, Department of Medicine, University of Massachusetts Ernest Mario School of Pharmacy, Rutgers, Joint Graduate Medical School, Worcester, MA, USA Program in Toxicology, Rutgers, The State University, Piscataway, NJ, USA Bernd Giebel Institute for Transfusion Medicine, University Hospital Nikiforos-Ioannis Kapetanakis Essen, University of Duisburg-Essen, Essen, Germany CNRS UMR8126, Gustave Roussy and Université Paris- Sud/Paris-Saclay, 39 rue Camille Desmoulins, Villejuif, Angelica Judith Granados-López France Laboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Doctorado en Ciencias Básicas, Universidad Tadashi Kimura Autónoma de Zacatecas, Zacatecas, Mexico Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan Rosalia Grande Department of Neuroscience, Imaging and Clinical Patrick Legembre Science, Section of Cardiovascular and Pharmacological Centre Eugène Marquis, Equipe Ligue Contre Le Cancer, Sciences, CeSI-MeT (Centro Scienze dell’ Invecchiamento