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The Science of Addiction SURGEON TURNS SCULPTOR the BIOLOGY of BELIEF SALUTING the CLASS of ’51 Editor’S Note

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The Science of Addiction SURGEON TURNS SCULPTOR the BIOLOGY of BELIEF SALUTING the CLASS of ’51 Editor’S Note UNIVERSITY OF PENNSYLVANIA MEDICAL CENTER■ SUMMER 2001 The Science of Addiction SURGEON TURNS SCULPTOR THE BIOLOGY OF BELIEF SALUTING THE CLASS OF ’51 Editor’s Note Saluting Bill Kelley Holmes introduced Gail Morri- involving multiple health profession- son, M.D. ’71, Penn’s vice dean for als. Because a variety of disciplines his spring, the School of education, as “the chief architect of and competencies come into play, he Medicine held a symposium the new curriculum.” Morrison list- suggested that the various health T in honor of William N. Kelley, ed several challenges the curriculum professionals be educated together. M.D., who served for more than 10 must face. The explosion of new In fact, he feels it would be beneficial years as dean of the school and CEO knowledge forces medical schools to to have them problem-solve as teams of Penn’s Health System. “Predic- reassess what needs to be taught while in training. Like Morrison, he tions for the Next Millennium” was and learned. The curriculum must emphasized that people must be moderated by Edward W. Holmes allow different ways of “keeping educated not just for life-long learn- Jr., M.D. ’67, vice chancellor for up” and encourage students to be ing but for change as well. health sciences and dean of the self-directed learners, often by using Francis S. Collins, M.D., Ph.D., School of Medicine at the University the newest technologies. Morrison director of the National Human of California at San Diego. (Holmes recalled that Kelley had charged her Genome Research Institute, was chaired Penn’s Department of Medi- with “a fundamental restructuring” recruited to the University of Michi- cine from 1991-97, recruited by Kel- of medical education. One part of gan by Kelley when Kelley was ley.) Describing the guest of honor as that vision, she said, remains elu- chair of its Department of Internal “one of the dominant figures in sive: making it more affordable. Medicine. Collins spoke about the American medicine,” Holmes assert- P. Roy Vagelos, M.D., former impact of the human genome pro- ed that Kelley had “transformed the chairman and CEO of Merck and ject and predicted how the future School of Medicine.” Kelley, he said, former chairman of the University was “all going to play out.” By 2010, worked to make it possible to trans- trustees, sketched out the great he envisioned predictive genetic late fundamental discoveries more advantages when the universities do tests for perhaps a dozen risks; quickly into patient care; mandated the basic research, the government preimplantation diagnosis will be an innovative curriculum; encour- bears part of the cost, and industry widely available (although the lim- aged one of the premier M.D./Ph.D. does the rest of the “discovery” its of the process will be “fiercely programs in the country; and work. He cited three areas in which debated”); and the federal govern- increased Penn’s NIH research fund- such productive partnerships had ment will pass effective legislation ing until it was second among all benefited patients tremendously: against genetic discrimination. By medical schools. As dean, Kelley coronary heart disease, hepatitis B, 2020, there will be gene-based recruited 20 department chairs – and and benign prostate enlargement. designer drugs on the market for made it possible to attract the very Among the issues raised by Ken- diabetes, hypertension, and several best medical students. At the sympo- neth I. Shine, M.D., president of the other conditions. Cancer therapies sium, several prominent friends and Institute of Medicine of the National will improve significantly. colleagues spoke on topics central to Academy of Sciences, was quality of By 2030, comprehensive Kelley’s vision of an integrated acad- care. Medical institutions, he assert- genomics-based health care will be emic health system. Following are ed, had lost leadership and credibili- the norm. Individualized preventive some brief highlights. ty in the eyes of the policy makers, medicine will be available. For Samuel O. Thier, M.D., president nor had they done a good job in many diseases, the interaction of and CEO of Partners HealthCare providing access to care. Quality, he environmental factors with the System in Boston, spoke about acad- said, “represents the last remaining human genotype will be pinpoint- emic health centers as “ground zero area” where medicine can take the ed. A full computer model of the for change in health policy.” He lead and convince the public that it human cell will replace many labo- noted that in the 1990s, funding from is doing so for the public’s benefit. ratory experiments. The average life the NIH rose to unprecedented levels For that, however, medical institu- span will reach 90 years; even so, – while reimbursements from insur- tions will need accurate measure- major anti-technology movements ance companies and Medicare went ments, which they have not had. will arise. Finally, there will be seri- down. Simultaneously, the burden of Shine also praised interdiscipli- ous debate about humans possibly uncompensated care for AHCs grew nary research. Yet, he said, “from a “taking charge” of their evolution. heavier. It is clear, said Thier, that the policy point of view, we keep subdi- Following the symposium, the old way of organizing a medical cen- viding and subdividing and subdi- visionary gave way to the pictorial. ter “is no longer viable.” viding,” and the way research is cur- After several speakers gave In general, Thier argued, acad- rently funded does not help interdis- remarks, a portrait of the guest of eme has the important role of con- ciplinary study. He ended his honor was unveiled. The portrait tributing ideas and models for pub- remarks by raising a related “central now hangs in Biomedical Research lic discourse. Academic health cen- issue”: the growth of systems of care Building II/III, constructed during ters should “ask the questions prop- Kelley’s tenure – and one of the erly and toughly” and “make sure most visible signs of his ambitious the debates are better informed” plans for Penn’s medical school and than they often are. Health System. Cover: Charles P. O’Brien, M.D., Ph.D. Photograph by Addison Geary UNIVERSITY OF PENNSYLVANIA MEDICAL CENTER / SUMMER 2001 VOLUME XIV, NUMBER 3 CONTENTS THE SCIENCE OF In his 30 years as director of Penn’s Treatment ADDICTION Research Center, Charles P. O’Brien, M.D., 6 By Lisa J. Bain G.M.E. ’69 Ph.D., has witnessed changes in the way scientists understand addiction, thanks to advances in neurochemistry, neurophysiology, and genetics. Despite resistance among many who deliver treatment, the trend in research today is to focus on using medication to treat addiction. IN THE STYLE OF When John A. Lanzalotti, M.D. ’75, found it HOUDON increasingly difficult to make a living as a sur- 15 By John Shea geon and physician, he was able to use his artistic talents and his skills at visualizing three dimensions to develop a business as a sculptor. His chief inspiration is Jean-Antoine Houdon, known for his busts of Franklin and other Founding Fathers. A PHOTOGRAPH OF In a new book, Andrew B. Newberg, M.D. ’93, GOD? and the late Eugene D’Aquili, M.D. ’66, Ph.D., 18 By Andrew B. Newberg, M.D. reported on their quest to study spiritual experience through the latest techniques of modern medicine. Using a SPECT camera, they found that the human brain alters during intense contemplation such as Buddhist medi- tation and the prayer of Roman Catholic nuns. CELEBRATING THE The questionnaires returned this spring by CLASS OF ’51 members of the Class of 1951 suggest that 21 many of them took the words of their old dean to heart: “If the demand for your services is great, your obligation to the community is correspondingly increased.” Fifty years later, these alumni have a record of achievement in many different areas. DEPARTMENTS EDITOR’S NOTE Inside Front LETTERS 4 Saluting Bill Kelley ALUMNI NEWS 28 VITAL SIGNS 2 It Happened One Weekend Mount Sinai’s Rubenstein is named Progress Notes new EVP, dean Gene therapy reverses blindness in dogs THE LAST WORD Inside Back A new tool for the era of proteomics ACampaign Concludes STAFF JOHN R. SHEA, Ph.D. Editor LEWIS & NOBEL DESIGN Design / Art Direction ADMINISTRATORS REBECCA HARMON Chief Public Affairs Officer MARCIA L. ROBERTS Director of Medical Alumni Relations and Institutional Events Penn Medicine is published for the alumni and friends of the University of Pennsylvania Medical Center by the Office of Public Affairs. © 2001 by the Trustees of the University of Pennsylvania. All rights reserved. Address all correspondence to John Shea, Penn Medicine, 2018 Penn Tower, University of Pennsylvania Medical Center, Philadelphia, PA 19104-4385, or call (215) 662-4802, or e-mail john .shea @uphs.upenn.edu. Visit Penn Medicine’s web site: http://www.med.upenn.edu/prnews/publications/Penn_Medicine.shtml 2001/SUMMER ■ 1 VitalSigns Robert Clink tion of American Physicians and of the Association of Professors of Medicine, he has also been chair- man of the American Board of Internal Medicine. Born in South Africa, Ruben- stein received his medical degree from the University of the Witwa- tersrand in Johannesburg in 1960. After affiliations with Witwater- srand, Johannesburg General Hos- pital, and the Hammersmith Hos- pital in London, he joined the Uni- Arthur H. Rubenstein, M.B., B. Ch., will lead Penn Med. versity of Chicago in 1967. As he made clear at his campus press conference, Rubenstein has Mount Sinai’s Rubenstein As executive vice president, devoted himself to all three compo- is named new EVP, dean Rubenstein will report to Judith nents of academic medicine: educa- Rodin, Ph.D., president of the Uni- tion, research, and patient care.
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