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Supplementary Table 1. Genes Increased 1.5-Fold Or Greater in Response to STAT3-C in NIH3T3 Cells (Clone E and Pool)

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Supplementary Table 1. Genes Increased 1.5-Fold Or Greater in Response to STAT3-C in NIH3T3 Cells (Clone E and Pool) Supplementary Table 1. Genes increased 1.5-fold or greater in response to STAT3-C in NIH3T3 cells (Clone E and Pool). Affymetrix Fold Induction Probe LocusLink Number Number Gene Name Clone E Pool 162206_f_at 12702 SOCS-3 7.66 5.36 101457_at 16452 Janus kinase 2 6.06 2.74 99602_at 21847 TGFB inducible early growth response 5.88 4.69 98579_at 13653 Early growth response 1 5.66 4.81 94358_at 20731 serine protease inhibitor, Kazal type 4 5.59 6.96 99603_g_at 21847 TGFB inducible early growth response 5.44 4.65 92232_at 12702 SOCS-3 5.13 3.85 100309_at 17295 met proto-oncogene 3.65 2.59 95701_at 67393 Uncharacterized EST 3.55 1.86 104066_at 106522 Uncharacterized EST 3.35 2.27 103508_at 76255 Uncharacterized EST 3.24 2.25 human immunodeficiency virus type I 92484_at 15273 enhancer-binding protein 2 3.16 2.9 protein tyrosine phosphatase, non-receptor 99970_at 24000 type 21 3.15 2.17 94477_at 18676 PHD finger protein 2 3.08 1.66 93460_at 11477 activin A receptor, type 1 3 2.21 99622_at 16600 Kruppel-like factor 4 (gut) 2.95 2.47 104293_at 72038 Uncharacterized EST 2.86 1.97 solute carrier family 30 (zinc transporter), 93938_at 22782 member 1 2.83 2.12 94489_at 19243 protein tyrosine phosphatase 4a1 2.78 1.94 gap junction membrane channel protein alpha 104635_r_at 14615 7 2.76 1.7 160353_i_at Uncharacterized EST 2.73 1.72 carbon catabolite repression 4 homolog (S. 99535_at 12457 cerevisiae) 2.72 2.85 96340_at 77975 Uncharacterized EST 2.68 1.84 97893_at 21895 TATA box binding protein-like protein 2.64 1.87 96127_at 103209 Uncharacterized EST 2.58 1.96 160376_at Uncharacterized EST 2.36 1.79 102811_at 14042 exostoses (multiple) 1 2.33 1.81 96126_at 20397 sphingosine phosphate lyase 1 2.29 1.83 99440_at 18028 nuclear factor I/B 2.27 1.6 160859_s_at Uncharacterized EST 2.27 1.58 95721_at 17164 MAP kinase-activated protein kinase 2 2.26 1.46 93985_at 99929 Uncharacterized EST 2.25 1.64 CCAAT/enhancer binding protein (C/EBP), 92925_at 12608 beta 2.22 1.92 160834_at Uncharacterized EST 2.22 1.73 102955_at 18030 nuclear factor, interleukin 3, regulated 2.18 2.13 98114_at 18145 Niemann Pick type C1 2.16 1.6 95345_at 21983 trophoblast glycoprotein 2.16 2 160890_at Uncharacterized EST 2.15 1.74 160261_i_at Uncharacterized EST 2.13 1.32 93975_at 74155 Uncharacterized EST 2.12 1.56 99158_at 20409 SH3 domain protein 3 2.11 1.72 103833_at 15258 Homeodomain interacting protein kinase 2 2.11 1.39 98024_at 18045 nuclear transcription factor-Y beta 2.11 1.38 104260_at 98667 Uncharacterized EST 2.1 1.63 97821_at 52541 Uncharacterized EST 2.09 1.5 102362_i_at 16477 Jun-B oncogene 2.08 1.98 103015_at 12053 B-cell leukemia/lymphoma 6 2.07 1.91 93358_at 66235 Uncharacterized EST 2.06 1.57 96523_at 13798 Engrailed 1 2.06 1.45 92767_at 12166 Bone morphogenetic protein receptor, type 1A 2.05 1.7 104453_at 50724 Uncharacterized EST 2.04 1.63 101040_at 12334 calpain 2 2.03 1.4 96192_at 20687 Trans-acting transcription factor 3 2.03 1.86 96003_at 23942 Metastasis associated 1-like 1 2.02 1.53 103826_at 16969 leukemia/lymphoma related factor 1.98 1.48 160326_at Uncharacterized EST 1.98 1.42 104701_at 20893 stimulated by retinoic acid 14 1.96 1.64 101002_at 54375 Ornithine decarboxylase antizyme inhibitor 1.94 1.55 100515_at 18550 proprotein convertase subtilisin/kexin type 3 1.94 1.5 160935_at Uncharacterized EST 1.92 1.89 97462_at 68036 Uncharacterized EST 1.9 1.49 100962_at 17937 Ngfi-A binding protein 2 1.88 1.93 103959_at Uncharacterized EST 1.88 1.86 99109_at 15936 immediate early response 2 1.85 1.79 96791_at Uncharacterized EST 1.85 1.46 97908_at 79046 Uncharacterized EST 1.84 1.31 transducin-like enhancer of split 1, homolog of 102425_at 21885 Drosophila E(spl) 1.84 1.61 161077_f_at Uncharacterized EST 1.84 1.45 nuclear factor of kappa light chain gene 101554_at 18035 enhancer in B-cells inhibitor, alpha 1.83 1.5 97527_at 66197 Uncharacterized EST 1.82 1.79 nuclear factor of kappa light chain gene 104149_at 18035 enhancer in B-cells inhibitor, alpha 1.81 1.56 97822_at 52541 Uncharacterized EST 1.8 1.54 95151_at 67220 Uncharacterized EST 1.8 1.25 93974_at 74155 Uncharacterized EST 1.78 1.85 97823_g_at 52541 Uncharacterized EST 1.78 1.55 103922_f_at 72017 Uncharacterized EST 1.78 1.67 95150_at 67220 Uncharacterized EST 1.76 1.29 94341_at 16468 Jumonji 1.75 1.31 99917_at 14056 Enhancer of zeste homolog 2 (Drosophila) 1.75 1.4 103520_at 22339 Vascular endothelial growth factor 1.75 1.3 92257_at 12753 circadian locomoter output cycles kaput 1.74 1.42 92867_at 54383 Early development regulator 2 (homolog of 1.73 1.49 polyhomeotic 2) 96010_at 16648 karyopherin (importin) alpha 3 1.73 1.36 93697_at 12418 Chromobox homolog 4 (Drosophila Pc class) 1.71 1.31 97463_g_at 68036 Uncharacterized EST 1.68 1.43 93187_at Uncharacterized EST 1.68 1.42 102105_f_at 19215 prostaglandin D2 synthase (21 kDa, brain) 1.67 1.37 95152_g_at 67220 Uncharacterized EST 1.66 1.31 160461_f_at Uncharacterized EST 1.64 1.52 97890_at 20393 serum/glucocorticoid regulated kinase 1.62 1.56 161774_f_at Uncharacterized EST 1.61 1.3 93093_at 17210 myeloid cell leukemia sequence 1 1.6 1.41 93976_at 12283 calcium binding protein, 39 kDa 1.59 1.29 97207_f_at 18777 Lysophospholipase 1 1.59 1.26 95571_at Zinc transporter 4 1.59 1.26 101499_at 16202 integrin linked kinase 1.58 1.47 93285_at 67603 Uncharacterized EST 1.57 1.45 102315_at Uncharacterized EST 1.57 1.43 98028_at 22160 Twist gene homolog, (Drosophila) 1.57 1.5 160808_at Uncharacterized EST 1.57 1.43 99835_at 14283 fos-like antigen 1 1.56 1.37 102309_at 54367 zinc finger protein 326 1.55 1.71 160835_i_at Uncharacterized EST 1.55 1.31 protein tyrosine phosphatase, non-receptor 100976_at 56294 type 9 1.53 1.29 97906_at 20439 seven in absentia 2 1.51 1.28 protein phosphatase 1, catalytic subunit, 101482_at 19047 gamma isoform 1.51 1.31 99399_at 11604 agouti related protein 1.51 1.26 95486_at 70547 Uncharacterized EST 1.5 1.39 102982_at Uncharacterized EST 1.5 1.39 104115_at 103554 Uncharacterized EST 1.5 1.45 104647_at 19225 prostaglandin-endoperoxide synthase 2 1.5 1.48 Supplementary Table 2. Affymetrix probes representing human orthologues of STAT3 targets identified in mouse fibroblasts. The Affymetrix chip, probe identification and gene name is shown. Affymetrix chip Probe Set Gene Hu6800 ACVR1: activin A receptor, Z22534_at type I X68560_at SP3: Sp3 transcription factor BCL6: B-cell CLL/lymphoma 6 U00115_at (zinc finger protein 51) PTPN21: protein tyrosine phosphatase, non-receptor X79510_at type 21 PTPN21: protein tyrosine phosphatase, non-receptor X79510_at type 21 PTPN21: protein tyrosine phosphatase, non-receptor RC_AA421778_at type 21 S79639_at EXT1: exostoses (multiple) 1 SGPL1: sphingosine-1- RC_AA459381_at phosphate lyase 1 PTP4A1: protein tyrosine phosphatase type IVA, U48296_at member 1 BMPR1A: bone morphogenetic protein Z22535_at receptor, type IA BMPR1A: bone morphogenetic protein N34737_s_at receptor, type IA X16707_at FOSL1: FOS-like antigen 1 MET: met proto-oncogene (hepatocyte growth factor AA129547_at receptor) EGR1: early growth response X52541_at 1 U85193_at NFIB: nuclear factor I/B U70862_at NFIB: nuclear factor I/B RC_AA425309_at NFIB: nuclear factor I/B KLF4: Kruppel-like factor 4 U70663_at (gut) KLF4: Kruppel-like factor 4 RC_AA621680_at (gut) X51345_at JUNB: jun B proto-oncogene RC_AA292228_at SOCS3 PAK2: p21 (CDKN1A)- U25975_at activated kinase 2 PAK2: p21 (CDKN1A)- U24153_at activated kinase 2 M32977_s_at VEGF: vascular endothelial growth factor VEGF: vascular endothelial M27281_at growth factor HIVEP2: human immunodeficiency virus type I X65644_at enhancer binding protein 2 MAPKAPK2: mitogen- activated protein kinase- X75346_s_at activated protein kinase 2 MAPKAPK2: mitogen- activated protein kinase- W58725_at activated protein kinase 2 MAPKAPK2: mitogen- activated protein kinase- U12779_at activated protein kinase 2 CAPN2: calpain 2, (m/II) large M23254_at subunit NPC1: Niemann-Pick disease, AF002020_at type C1 NFIL3: nuclear factor, U26173_s_at interleukin 3 regulated TPBG: trophoblast Z29083_at glycoprotein TIEG: TGFB inducible early S81439_at growth response NFYB: nuclear transcription X59710_at factor Y, beta NFYB: nuclear transcription X59710_at factor Y, beta MCL1: myeloid cell leukemia L08246_at sequence 1 (BCL2-related) W58709_at PHF2: PHD finger protein 2 OSTF1: osteoclast stimulating U63717_at factor 1 Affymetrix chip Probe Set Gene U95 ACVR1: activin A receptor, 39764_at type I BCL6: B-cell CLL/lymphoma 6 40091_at (zinc finger protein 51) BMPR1A: bone morphogenetic protein 39565_at receptor, type IA CAPN2: calpain 2, (m/II) large 37001_at subunit EGR1: early growth response 789_at 1 32164_at EXT1: exostoses (multiple) 1 222_at EXT1: exostoses (multiple) 1 32271_at FOSL1: FOS-like antigen 1 37468_at JAK2 32786_at JUNB: jun B proto-oncogene KLF4: Kruppel-like factor 4 36214_at (gut) MAPKAPK2: mitogen- activated protein kinase- 36180_s_at activated protein kinase 2 MAPKAPK2: mitogen- activated protein kinase- 36179_at activated protein kinase 2 MAPKAPK2: mitogen- activated protein kinase- 1469_at activated protein kinase 2 MAPKAPK2: mitogen- activated protein kinase- 1439_s_at activated protein kinase 2 MCL1: myeloid cell leukemia 33146_at sequence 1 (BCL2-related) MCL1: myeloid cell leukemia 277_at sequence 1 (BCL2-related) MET: met proto-oncogene (hepatocyte growth factor 35684_at receptor) 463_g_at NFIB: nuclear factor I/B 462_at NFIB: nuclear factor I/B 34720_at NFIB: nuclear factor I/B NFIL3: nuclear factor, 37544_at interleukin 3 regulated NFYB: nuclear transcription 37928_at factor Y, beta NPC1:
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