University of Rhode Island DigitalCommons@URI Open Access Master's Theses 1966 Some Pharmacological Properties of Trimethoxy Analogs of Pheniramine, Tripelennamine, and Diphenhydramine Ronald Otto Langner University of Rhode Island Follow this and additional works at: https://digitalcommons.uri.edu/theses Recommended Citation Langner, Ronald Otto, "Some Pharmacological Properties of Trimethoxy Analogs of Pheniramine, Tripelennamine, and Diphenhydramine" (1966). Open Access Master's Theses. Paper 200. https://digitalcommons.uri.edu/theses/200 This Thesis is brought to you for free and open access by DigitalCommons@URI. It has been accepted for inclusion in Open Access Master's Theses by an authorized administrator of DigitalCommons@URI. For more information, please contact
[email protected]. SOME PHARMACOLOGICAL PRDPERTIES OF TRIMETHOXY ANALOGS OF PHENIRAMINE,_ TRIPELENNAMINE, AND DIPHENHYDRAMINE BY RONALD OT'ID LANGNER A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FDR THE DEGREE OF MASTER OF SCIENCE IN PHARMACOLOGY UNIVERSITY OF RHODE ISLAND 1966 ABSTRACT Trimethoxy analogs of tripelennamine, diphenhydramine, and pheniramine were studied to determine the influences of the tri methoxy group on the pharmacological activity of known antihista mines. In this investigation, the ability of the parent compounds and their analogs to antagonize the histamine-induced contractions of guinea pig ilia were studied as well as their effects on the systolic blood pressure of male albino rats and on the central nervous system of mice as measured by the actophotometer. 'lhe trimethoxy analogs were comparatively weak competitive antagonists of histamine with the exception of N,N,-Diethyl-N' (2-pyridyl)-N'-(3,4,S-trimethoxybenzyl) ethylenediamine Dicyclamate (De-TMPBZ) and N,N,-Diethyl-N'-(2-pyridyl)-N'-(3,4,5-trimethoxy benzyl) ethylenediamine Disuccinate (TMPBZ) which were weak non competitive histamine antagonists.