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Book of Abstracts MYCOTOXINS and PHYCOTOXINS

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Book of Abstracts MYCOTOXINS and PHYCOTOXINS TRN I 'ZA<g700^12 - Book of Abstracts INIS-mf — 11062 AND i - 22-25 JULY 1985 SIXTH INTERNATIONAL SYMPOSIUM ON MYCOTOXINS AND PHYCOTOXINS CSIR CONFERENCE CENTRE PRETORIA REPUBLIC OF SOUTH AFRICA SIXTH INTERNATIONAL SYMPOSIUM on MYCOTOXINS AND PHYCOTOXINS ABSTRACTS 22-25 JULY 1985 CSIR CONFERENCE CENTRE PRETORIA REPUBLIC OF SOUTH AFRICA under the auspices of INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY SOUTH AFRICAN COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH and the SA Association for Food Science and Technology SA Biochemical Society SA Chemical Institute SA Society for Animal Production SA Society for Plant Pathology SA Veterinary Association with the assistance of the CSIR Symposium Secretariat S.3S1 PLENARY PRESENTATIONS Synthetic studies on fungal metabolites and other natural products G Biichi PL1 Regulation of secondary metabolism in fungi A L Demain PL 2 Biomimetic synthesis of aromatic polyketide metabolites T M Harris and C M Harris PL 3 Global significance of mycotoxins C W Hessertine PL 4 Biology of toxigenic anamorphs B Kendrick PL 5 Biochemical mechanism of action of mycotoxins K-H Kiessling PL 6 Toxins from cyanophytes belonging to the Scytonemaceae R E Moore PL 7 Sampling, sample preparation, and sampling plans for foodstuffs for mycotoxin analysis D L Park, A D Campbell, T B Whitaker, A E Pohland and J W Dickens Abstract not received Pathology of mycotoxicoses: possibilities and limits of diagnosis HBSchieffer PL 8 Toxigenesis and biosynthesis of saxitoxin analogs YShimizu PL 9 Recent structural studies on mould metabolites CHTamm PL 10 Progress towards a biosynthetic rationale of the aflatoxin pathway CATownsend PL 11 Toxicology of naturally occurring microbial toxins YUeno PL 12 Determination of mycotoxins H van Egmond and W E Paulsch PL 13 -J. •• Biosynthetic studies on some polyene mycotoxins RVteggaar PL 14 SECTION LECTURES Page Secondary metabolites produced by some Fusarium species J W ApSimon, B Blackwell, R Greenhalgh, R R King, R-M Meier, D Miller, J R J Pare and A Taylor S 1 The genetic basis of mycotoxin biosynthesis JW Bennett S2 Cyanoginosins - isolation, structure and biology D P Botes S 3 Mechanism of action for peptide toxins of freshwater cyanobacteria (blue-green algae) WWCarmichael S4 Recent studies on the immunochemical analysis of mycotoxins F S Chu S 5 A comparative study of the pathology of the ovine hepatogenous photosensitivity diseases, facial eczema and geeldikkop (tribulosis ovis), with special reference to their pathogenesis JAW Coetzer, T S Kellerman, W Sadler and G F Bath S 6 The role of tremorgenic mycotoxins in animal diseases R J Cole S 7 Lupinosis. The chemistry and biochemistry of the phomopsins J A Edgar S 8 Mycotoxin biosynthesis from di- to nonaketide precursors B Franck S 9 Mass spectrometry and n.m.r. spectroscopy of fungal extracts of some Fusarium species. R Greenhalgh Abstract not received Chemical studies relevant to the synthesis of some mycotoxins: the cyclopiazonic acids and viridamine CWHolzapfel S10 The role of aflatoxin in human cancer DPHHsieh S11 Analysis and dynamics of ochratoxin A in biological systems K Hurt S12 Synthetic studies on marine toxic polyethers - total synthesis of okadaic acid Mlsobe S13 3 Page Mycotoxicoses of livestock in South Africa TSKellerman S14 Anti-cyanoginosin-LA monoclonal antibody: preparation and characterization R Kfir, E Johannsen and D P Botes S 15 Chronic pathological effects of some fusarial toxins N P J Kriek, W F O Marasas, S J van Rensburg, B Yagen and AZJoffe S16 The analysis and occurrence of patulin in apple juices SJKubacki S17 The natural contamination of cereals by toxic trichothecenes: risk to human health H Kurata and M Ichinoe S18 Factors affecting toxin production by fungi JLacey S19 Mechanism of action of the territrems, tremorgenic mycotoxins isolated from Aspergillus terreus K H Ling, H H Liou, T C Fu, L Kuo, M C Tsai and M Y Lin S 20 Hepatic metabolism and elimination of tremorgenic mycotoxins P G Mantle S 21 Fusarium moniliforme: A mycotoxicological miasma W F O Marasas S 22 Metabolism and residues of trichothecenes in different animals and tissues CJMirocha S23 Chemistry of some cytoreactive mold metabolites - A epitetrathiodioxopiperazine and two new cytochalasans S Natori S 24 Hepatocarcinogenicity of corn screenings naturally contaminated with Fusarium moniliforme P E Nelson and T M Wilson S 25 A rationale for the control of aflatoxin in feeds D L Park, A E Pohland and L Stoloff S 26 Aflatoxic suppression of cell mediated immune responses and interaction with T-2 toxin A C Pier, M J Varman and E L Belden S 27 4 Page Mass spectrometry/mass spectrometry as a tool for the identification and quantitation of mycotoxins R D Plattner S 28 Conformation of cyclic peptides: rhizonin and phomopsin A M Potgieter S 29 Commercial detoxification of aflatoxin-contaminated peanut meal A Prevot S 30 Important lesser known toxigenic fungi C J Rabie S 31 Analysis of toxins of Fusarium moniliforme P M Scott S 32 Physiological and morphological interactions in the toxic blue-green alga (Cyanobacterium) Microcystis aeruginosa W E Scott S 33 Biosynthetic studies on microbial metabolites containing a carbon- phosphorus bond H Seto S 34 Structural and biosynthetic studies on polyketide mycotoxins and fungal metabolites T J Simpson S 35 Molecular aspects of aflatoxin B, mutagenesis and carcinogenesis A-A Stark S36 Total synthesis of corynetoxins and tunicamycins T Suami S 37 Analytical techniques for dinoflagellate toxins J J Sullivan S 38 HPLC determination of aflatoxins and mammalian aflatoxin metabolites * PGThiel S39 Sequence determination of cyclic peptides by mass spectrometry • A A Tuinman S 40 < Role of mycotoxins in endemic liver and oesophageal cancer | S J van Rensburg S 41 Biosynthetic studies on mycotoxins using multiple stable isotope labelling and n.m.r. spectroscopy J C Vederas S 42 5 Page Conformations of mycotoxins utilizing X-ray diffraction and molecular mechanics techniques W H Watson S 43 Kinetic pulse labelling in the biosynthesis of mycotoxins L O Zamir S 44 POSTER PRESENTATIONS Page B BASIC ASPECTS OF SECONDARY METABOLISM IN RELA- TION TO TOXIN PRODUCTION B1 Effect of water activity (Aw) on the production of asteltoxin by Emericella variecolor (Berk, et Br.) A E de Jesus, R M Horak, E M Lawson, and M Patel P1 B2 Effect of different antioxidants and free radical scavengers on aflatoxin production C Fanelli, A A Fabbri, S Pieretti, E Finotti, and S Passi P 2 B3 Microsomal and mitochondrial involvement in the production of aflatoxins induced by carbon tetrachloride in cultures of Asper- gillus parasiticus S Passi, M Nazzaro-Porro, E Finotti, G Panfili, A A Fabbri, and C Fanelli P3 B4 The effect of heat and radiation on germination and ochratoxin production of sclerotia of Aspergillus ochraceus N Paster, R Barkai-Golan, and R Padova P 4 B5 Production of fusarin C in liquid culture J M Farber, G W Sanders, and P M Scott P 5 B6 Zearalenone production by Fusarium species isolated from soy- beans G Vaamonde, N B Bonera, and G T Scarmato P 6 B7 Effect of culture conditions on the toxicity and chemical compo- sition of the toxin of Microcystis aeruginosa (UV 006) A J van der Westhuizen, J N Eloff, and G H J Kruger P 7 C BIOSYNTHESIS OF MYCOTOXINS AND PHYCOTOXINS C1 O-Methyltransferases and aflatoxin biosynthesis R K Berry and M F Dutton P 8 C2 Metabolism of aflatoxin B2. by Aspergillus flavus M F Dutton P 9 C3 The effect of ethanol on the metabolite production of Aspergil- lus ustus A E de Jesus, R M Horak, P S Steyn, and R Vleggaar P10 Page C4 Isolation, purification, and characterization of EC oxidase that transforms eremofortin C to PR toxin ' -' Y H Wei, S C Chang, and R D Wei P11 l; C5 A 13C n.m.r. study of the biosynthesis of secondary metabolites of Fusarium culmorum ; B A Blackwell, J D Miller, R Greenhalgh, and L Zamir P12 h C6 Biosynthesis of 3-acetyldeoxynivalenol and other metabolites '>• by Fusarium culmorum in a stirred jar fermentor J D Miller and B A Blackwell P13 E STRUCTURE AND CHEMICAL PROPERTIES OF MYCOTOX- INS AND PHYCOTOXINS E1Carbon-13 and proton resonance assignments in leucinostatin A C G Casinovi, L Radios, C Rossi, and L Tuttobello P14 E2 Structure/activity relationships of the fusarins W C A Gelderblom, P G Thiel, and K J van der Merwe P15 E3 Structure elucidation of the first naturally occurring trichothe- cene glycoside, a metabolite of Fusarium sulphureum C P Gorst-Allman, C J Rabie, P S Steyn, and R Vleggaar P16 E4 Unique insecticidal mycotoxin from Aspergillus melleus Yukawa isolated from cadaver of silkworm, Bombyx mori L T Ohtomo, H Sato, and K Yoshida P 17 E5 Quantum chemical studies of aflatoxin Bi, sterigmatocystin and versicolorin A and a comparison with their mutagenic activity R Pachter and P S Steyn P18 E6 Unexpected cyclizations upon oxidation of diplodiatoxin M Potgieter and P S Steyn P19 E7 Chemical reactions of the penitrems F R van Heerden, P S Steyn, and R Vleggaar P 20 E8 Trichothecenes from Fusarium compactum C M Maes, R M Horak, W F O Marasas, C J Rabie, P S Steyn, and R Vleggaar P 21 E9 Some secondary metabolites of Fusarium culmorum and F. roseum R Greenhalgh, R-M Meier, D Levandier, B A Blackwell, J D Miller, A Taylor, and J W ApSimon P 22 Page E10 Reduction in levels of deoxynivalenol and its fate in contami- nated soft wheat after chemical treatment J C Young, L Subryan, and D Potts P 23 E11 Some mycotoxin structures determined by X-ray crystallo- graphy at the NCRL J L M Dillen and P H van Rooyen P 24 G ANALYSIS OF MYCOTOXINS AND PHYCOTOXINS
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