中國內地指定醫院列表 出版日期: 2019 年 7 月 1 日 Designated Hospital List in Mainland China Published Date: 1 Jul 2019
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Perillyl Alcohol Conjugate Downregulates O6-Methylguanin DNA Methltransferase Via Inducing Ubiquitination-De
Song et al. Cell Death and Disease (2018) 9:202 DOI 10.1038/s41419-017-0193-2 Cell Death & Disease ARTICLE Open Access Temozolomide–perillyl alcohol conjugate downregulates O6- methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer Xingguo Song1,LiXie1,2,MinghuiChang2,3,XinranGeng4,XingwuWang1,ThomasC.Chen5 and Xianrang Song 1,2 Abstract The DNA repair enzyme O6-methylguanin-DNA-methltransferase (MGMT) is able to remove products of alkylating agent such as O6-meG and emerges as a central determinant of cancer resistance to temozolomide (TMZ). Temozolomide–perillyl alcohol conjugate (TMZ–POH), a novel TMZ analog developed based on the conjugation of TMZ and POH, displayed strong anticancer potency in multiple cancer types, but seemed not to experience the chemoresistance even in cells with high MGMT expression unlike TMZ and other alkylating agents. In this study, we demonstrated TMZ–POH inhibited MGMT dependent on proteasomal pathway and this inhibition is a significant factor in its toxic effect in the non-small cell lung cancer (NSCLC) cells. 1234567890():,; 1234567890():,; Introduction such as O6-methyl-guanine (O6-meG), which trigger cell Nowadays, chemotherapy has been traditionally con- cycle-dependent DNA damage and cell death4. Although sidered as one of the standard treatment options for TMZ chemotherapy may enhance survival of cancer cancer patients, but the chemoresistance dramatically patients, intrinsic or acquired resistance to TMZ is also hinders its clinical application, especially for alkylating common and accounts for many treatment failures5, agents like temozolomide (TMZ)1. TMZ, an imidazote- because TMZ-induced DNA alkylation damage can be trazine derivative of the alkylating agent dacarbazine, was repaired by O6-methylguanin-DNA-methltransferase approved by the US FDA (Food and Drug Administration) (MGMT)6. -
Loan Agreement
CONFORMED COPY LOAN NUMBER 4794-CHA Public Disclosure Authorized Public Disclosure Authorized Loan Agreement (Chongqing Small Cities Infrastructure Improvement Project) between PEOPLE’S REPUBLIC OF CHINA Public Disclosure Authorized and INTERNATIONAL BANK FOR RECONSTRUCTION AND DEVELOPMENT Dated September 10, 2005 Public Disclosure Authorized 2 LOAN NUMBER 4794-CHA LOAN AGREEMENT AGREEMENT, dated September 10, 2005, between PEOPLE’S REPUBLIC OF CHINA (the Borrower) and INTERNATIONAL BANK FOR RECONSTRUCTION AND DEVELOPMENT (the Bank). WHEREAS (A) the Borrower, having satisfied itself as to the feasibility and priority of the project described in Schedule 2 to this Agreement (the Project), has requested the Bank to assist in the financing of the Project; (B) the Project will be carried out by Chongqing (as defined in Section 1.02) with the Borrower’s assistance and, as part of such assistance, the Borrower will make the proceeds of the loan provided for in Article II of this Agreement (the Loan) available to Chongqing, as set forth in this Agreement; and WHEREAS the Bank has agreed, on the basis, inter alia, of the foregoing, to extend the Loan to the Borrower upon the terms and conditions set forth in this Agreement and in the Project Agreement of even date herewith between the Bank and Chongqing (the Project Agreement); NOW THEREFORE the parties hereto hereby agree as follows: ARTICLE I General Conditions; Definitions Section 1.01. The “General Conditions Applicable to Loan and Guarantee Agreements for Single Currency Loans” of the Bank, dated May 30, 1995 (as amended through May 1, 2004) with the following modification (the General Conditions), constitute an integral part of this Agreement, namely, that Section 6.03(c) of the General Conditions is amended by replacing the words “corrupt or fraudulent” with the words “corrupt, fraudulent, collusive or coercive”. -
Spatiotemporal Evolution Analysis of Agricultural Non-Point Source Pollution Risks in Chongqing, China, Based on the Ito3de Model and GIS
Spatiotemporal evolution analysis of agricultural non-point source pollution risks in Chongqing, China, based on the ITO3dE model and GIS Kang-wen ZHU Southwest University Zhi-min YANG Southwest University Lei HUANG Southwest University Yu-cheng CHEN ( [email protected] ) Southwest University Sheng ZHANG Chongqing Academy of Ecology and Environmental Sciences Hai-ling XIONG Southwest University Sheng WU Southwest University Bo LEI Chongqing Academy of Ecology and Environmental Sciences Research Article Keywords: Agricultural non-point source pollution (AGNPS), ITO3dE model, Transition matrix, Kernel density, GIS Posted Date: December 9th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-115722/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Version of Record: A version of this preprint was published at Scientic Reports on February 25th, 2021. See the published version at https://doi.org/10.1038/s41598-021-84075-2. 1 Spatiotemporal evolution analysis of agricultural non-point source pollution risks in 2 Chongqing, China, based on the ITO3dE model and GIS 3 Kang-wen ZHUa, Zhi-min YANGa, Lei HUANGa, Yu-cheng CHENa*, Sheng ZHANGb*, Hai-ling 4 XIONGc, Sheng WUc, Bo LEIb 5 aCollege of Resources and Environment, Southwest University, 400716, China 6 bChongqing Academy of Ecology and Environmental Sciences, Chongqing, 401147, China 7 cCollege of computer & information science, Southwest University, 400716, China 8 Abstract 9 To determine the risk state distribution, risk level, and risk evolution situation of agricultural non-point source 10 pollution (AGNPS), we built an ‘Input-Translate-Output’ three-dimensional evaluation (ITO3dE) model that 11 involved 12 factors under the support of GIS and analyzed the spatiotemporal evolution characteristics of AGNPS 12 risks from 2005 to 2015 in Chongqing by using GIS space matrix, kernel density analysis, and Getis-Ord Gi* analysis. -
Investigation and Analysis of Rational Drug Use of Residents In
Journal ofof ClinicalContem andporary Nursing Education Research Research Research Article Investigation and Analysis of Rational Drug Use of Residents in Changshou District of Chongqing, China Yu Jiangxia1, Fan Yongtong1*, Wu Ruizhu1, Ji Huanhuan2 1Chongqing Chemical Industry Vocational College, Chongqing, 400020, China, 2Children’s Hospital of Chongqing Medical University, Chongqing, 400020, China Abstract: The objective of this study was to acquire drugs for patients with hyperlipidemia, hypertension, the information about residents of Changshou District’s and hyperglycemia (32%), vitamins (24%), drugs for knowledge levels and their behaviors of drug use the treatment of common cold and cough (20%), and so that implementation strategies of rational drug others. Publicity of rational drug use should not be use can be formulated accordingly to promote and restricted to specific population, and knowledge of spread health education of rational drug use. Online safe drug use is supposed to be actively popularized. and offline surveys were randomly conducted about Contents of rational drug use are as follows: Guide rational drug use conditions of residents in Changshou the public to correctly understand the functions of District by questionnaires. Online questionnaires vitamins and dietary supplements strengthen publicity were sent to residents of Changshou District by of rational use of drugs such as antibiotics, antibacterial Wenjuanxing, a professional platform used for surveys. drugs, drugs for chronic diseases, cold, and cough. Offline questionnaires were mainly distributed to Focus should be given on usage and dosage of drugs, residents of communities in Changshou District. All use of antibacterial drugs, and repeated and excessive the online and offline statistics were analyzed and use of drugs caused by joint use of drugs with same counted. -
Chongqing Urban–Rural Infrastructure Development Demonstration II Project — Resettlement External Monitoring Report (No
Resettlement External Monitoring Report #7 June–December 2018 January 2019 People’s Republic of China: Chongqing Urban–Rural Infrastructure Development Demonstration II Project — Resettlement External Monitoring Report (No. 7) Prepared by the Halcrow (Chongqing) Engineering Consulting Co. Ltd. for the People’s Republic of China and the Asian Development Bank. This resettlement external monitoring report is a document of the borrower. The views expressed herein do not necessarily represent those of ADB's Board of Directors, Management, or staff, and may be preliminary in nature. In preparing any country program or strategy, financing any project, or by making any designation of or reference to a particular territory or geographic area in this document, the Asian Development Bank does not intend to make any judgments as to the legal or other status of any territory or area. ADB-Financed Chongqing Urban–Rural Infrastructure Development Demonstration Project II Resettlement External Monitoring Report (No. 7) (Jun 2018---Dec 2018) Halcrow (Chongqing) Engineering Consulting Co. Ltd. Jan 2019 I Contents Contents ................................................................................................................................................. II 1. Introduction ........................................................................................................................................ 1 1.1 Brief Introduction of the Project .................................................................................................................. -
Annual Report 2019 X
CHAPTER I Definition 2 CHAPTER XI Corporate Governance Report 102 CHAPTER II Risk Warnings 5 I. Overview of Corporate Governance 102 CHAPTER III Company Profile 6 II. General Meeting 102 I. Profile 6 III. Performance of the Directors 104 II. History 9 IV. Work Performance of Board of Directors and 111 III. Staff Profile 11 Special Committees IV. Brief Introduction of the Organs and Branches 12 V. Chairman and General Manager 123 V. Basic Information about the Industry in Which the 16 VI. Securities Transactions by the Directors, Supervisors and 125 Company Operates Senior Management VI. Business Briefings of the Company 16 VII. Performance of Duties by Independent Non-executive 125 VII. Briefings of our Subsidiaries 17 Directors VIII. Honours Awarded to the Company During the 18 VIII. Supervision on Risk Management and Internal Control 125 Reporting Period System CHAPTER IV Financial Summary 20 IX. Other Relevant Matters 128 I. Major Accounting Data of the Group 20 CHAPTER XII Internal Control 133 II. Major Financial Indexes of the Group 20 I. Establishment of Internal Control Structure 133 III. Net Capital of the Company and Relevant Risk Control 21 II. Implementation and Operation of Internal Control System 133 Indicators III. Supervision and Inspection of Internal Control 133 IV. Financial Conditions of the Group of the Latest Five Years 22 IV. Conclusion of the Assessment of Internal Control 134 CHAPTER V Chairman Statement 23 CHAPTER XIII Independent Auditor’s Report 135 CHAPTER VI Management Discussion and Analysis 25 CHAPTER XIV Notes to the Consolidated Financial 140 I. Economic and Futures Market Analysis during the 25 Statements Reporting Period Consolidated Statements of Comprehensive Income 140 II. -
Role of PARP1-Mediated Autophagy in EGFR-TKI Resistance in Non
www.nature.com/scientificreports OPEN Role of PARP1‑mediated autophagy in EGFR‑TKI resistance in non‑small cell lung cancer Zhimin Zhang1,4, Xiaojuan Lian2,4, Wei Xie1, Jin Quan2, Maojun Liao1, Yan Wu3, Zhen‑Zhou Yang3,4* & Ge Wang1,4* Resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) has become the main clinical challenge of advanced lung cancer. This research aimed to explore the role of PARP1‑ mediated autophagy in the progression of TKI therapy. PARP1‑mediated autophagy was evaluated in vitro by CCK‑8 assay, clonogenic assay, immunofuorescence, and western blot in the HCC‑827, H1975, and H1299 cells treated with icotinib (Ico), rapamycin, and AZD2281 (olaparib) alone or in combination. Our results and GEO dataset analysis confrmed that PARP1 is expressed at lower levels in TKI‑sensitive cells than in TKI‑resistant cells. Low PARP1 expression and high p62 expression were associated with good outcomes among patients with NSCLC after TKI therapy. AZD2281 and a lysosomal inhibitor reversed resistance to Ico by decreasing PARP1 and LC3 in cells, but an mTOR inhibitor did not decrease Ico resistance. The combination of AZD2281 and Ico exerted a markedly enhanced antitumor efect by reducing PARP1 expression and autophagy in vivo. Knockdown of PARP1 expression reversed the resistance to TKI by the mTOR/Akt/autophagy pathway in HCC‑827IR, H1975, and H1299 cells. PARP1‑mediated autophagy is a key pathway for TKI resistance in NSCLC cells that participates in the resistance to TKIs. Olaparib may serve as a -
2020 INTERIM REPORT Corporate Information (Continued)
INTERIM REPORT CONTENTS Corporate Information 2 Chairman’s Statement 4 Management Discussion and Analysis 7 Corporate Governance 32 Disclosure of the Interests Information 34 Other Information 40 Review Report on the Interim Financial Information 45 Consolidated Statement of Comprehensive Income 46 Consolidated Statement of Financial Position 48 Consolidated Statement of Changes in Equity 50 Condensed Consolidated Cash Flow Statement 53 Notes to the Unaudited Interim Financial Statements 54 Corporate Information BOARD OF DIRECTORS NOMINATION COMMITTEE Executive Directors Mr. Yi Xiaodi (Chairman) Mr. Yi Xiaodi (Chairman) Mr. Gu Yunchang Mr. Fan Xiaochong (Vice Chairman) Mr. Wang Bo Non-executive Directors JOINT COMPANY SECRETARIES Ms. Fan Xiaohua Mr. Tsang Ho Yin Mr. Wang Gongquan Mr. He Jie Independent non-executive Directors COMPANY’S WEBSITE Mr. Gu Yunchang www.ss100.com.cn Mr. Ng Fook Ai, Victor Mr. Wang Bo AUTHORISED REPRESENTATIVES AUDIT COMMITTEE Mr. Yi Xiaodi Mr. Tsang Ho Yin Mr. Ng Fook Ai, Victor (Chairman) Mr. Gu Yunchang Mr. Wang Bo REGISTERED OFFICE 190 Elgin Avenue REMUNERATION COMMITTEE George Town, Grand Cayman KY1–9005 Mr. Wang Bo (Chairman) Cayman Islands Mr. Fan Xiaochong Mr. Gu Yunchang 2 2020 INTERIM REPORT Corporate Information (Continued) HEAD OFFICE PRINCIPAL BANKS Tower D, Floor 12 Agricultural Bank of China No. 2 Guang Hua Road China Everbright Bank Beijing 100026 China Minsheng Banking Corp., Ltd. PRC China Zheshang Bank Co., Ltd. Hua Xia Bank Co., Ltd. PRINCIPAL PLACE OF BUSINESS IN HONG KONG HONG KONG BRANCH SHARE 39/F, Gloucester Tower, REGISTRAR AND TRANSFER OFFICE The Landmark, 15 Queen’s Road Central, Computershare Hong Kong Investor Services Limited Hong Kong Shops 1712–1716, 17th Floor, Hopewell Centre PRC 183 Queen’s Road East Wanchai Hong Kong LEGAL ADVISER PRC Morrison & Foerster PRINCIPAL SHARE REGISTRAR AND AUDITOR TRANSFER OFFICE KPMG SMP Partners (Cayman) Limited 8th Floor, Prince’s Building Royal Bank House – 3rd Floor 10 Chater Road 24 Shedden Road Central P.O. -
Download Thesis
This electronic thesis or dissertation has been downloaded from the King’s Research Portal at https://kclpure.kcl.ac.uk/portal/ Across the Geo-political Landscape Chinese Women Intellectuals’ Political Networks in the Wartime Era 1937-1949 Guo, Xiangwei Awarding institution: King's College London The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without proper acknowledgement. END USER LICENCE AGREEMENT Unless another licence is stated on the immediately following page this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence. https://creativecommons.org/licenses/by-nc-nd/4.0/ You are free to copy, distribute and transmit the work Under the following conditions: Attribution: You must attribute the work in the manner specified by the author (but not in any way that suggests that they endorse you or your use of the work). Non Commercial: You may not use this work for commercial purposes. No Derivative Works - You may not alter, transform, or build upon this work. Any of these conditions can be waived if you receive permission from the author. Your fair dealings and other rights are in no way affected by the above. Take down policy If you believe that this document breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 30. Sep. 2021 Across the Geo-political Landscape: Chinese Women Intellectuals’ Political -
Printmgr File
DIRECTORS, SUPERVISORS AND PARTIES INVOLVED IN THE GLOBAL OFFERING DIRECTORS Name Address Nationality Executive Directors Sun Nengyi No. 2-301 Block 6 Chinese Gulousi Village Nanan District Chongqing City China He Yong 6-2 Unit 3 Chinese No. 1 Yuanbao Village Shuangqiao District Chongqing City China Liao Shaohua No. 12 to No. 130 Chinese Jingjian Village Huaxi Town Banan District Chongqing City China Chen Xianzheng 9-4 Unit 1 Chinese No. 8 Gulouwu Village Nanan District Chongqing City China Non-executive Directors Huang Yong 4-5 Block 25 Chinese No. 1111 Jinkai Road Yubei District Chongqing City China Yu Gang 23-1 Chinese No. 26 Danlong Road Nanan District Chongqing City China 61 DIRECTORS, SUPERVISORS AND PARTIES INVOLVED IN THE GLOBAL OFFERING Name Address Nationality Yang Jingpu 3-2 Block 1 Chinese No. 46-1 Yanyu Castle Nanan District Chongqing City China Wu Jian Unit 1 Chinese No. 9 Daijia Village Yuzhong District Chongqing City China Independent non-executive Directors Lo Wah Wai Duplex C, 19th and 20th Floor Chinese Tower 1, The Astrid 180 Argyle Street Ha Tan Wei Kowloon Hong Kong Ren Xiaochang No. 1 on Level 4 Chinese Unit 1 Block 25 Zhujiang Garden Jiulongpo District Chongqing City China Kong Weiliang 16-4 Chinese No. 2-128 Beixia Road Beibei District Chongqing City China 62 DIRECTORS, SUPERVISORS AND PARTIES INVOLVED IN THE GLOBAL OFFERING Name Address Nationality SUPERVISORS Duan Rongsheng 15-3 Chinese No. 155 Zhongshansan Road Yuzhong District Chongqing City China Ye Zusheng 7-2 Chinese No. 385 Xinhua Road Shizhong District Chongqing City Sichuan Province China Wang Rongxue 1-2 Chinese No. -
Geographical Overview of the Three Gorges Dam and Reservoir, China—Geologic Hazards and Environmental Impacts
Geographical Overview of the Three Gorges Dam and Reservoir, China—Geologic Hazards and Environmental Impacts Open-File Report 2008–1241 U.S. Department of the Interior U.S. Geological Survey Geographical Overview of the Three Gorges Dam and Reservoir, China— Geologic Hazards and Environmental Impacts By Lynn M. Highland Open-File Report 2008–1241 U.S. Department of the Interior U.S. Geological Survey U.S. Department of the Interior DIRK KEMPTHORNE, Secretary U.S. Geological Survey Mark D. Myers, Director U.S. Geological Survey, Reston, Virginia: 2008 For product and ordering information: World Wide Web: http://www.usgs.gov/pubprod Telephone: 1-888-ASK-USGS For more information on the USGS—the Federal source for science about the Earth, its natural and living resources, natural hazards, and the environment: World Wide Web: http://www.usgs.gov Telephone: 1-888-ASK-USGS Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Although this report is in the public domain, permission must be secured from the individual copyright owners to reproduce any copyrighted materials contained within this report. Suggested citation: Highland, L.M., 2008, Geographical overview of the Three Gorges dam and reservoir, China—Geologic hazards and environmental impacts: U.S. Geological Survey Open-File Report 2008–1241, 79 p. http://pubs.usgs.gov/of/2008/1241/ iii Contents Slide 1...............................................................................................................................................................1 -
National Reports on Wetlands in South China Sea
United Nations UNEP/GEF South China Sea Global Environment Environment Programme Project Facility “Reversing Environmental Degradation Trends in the South China Sea and Gulf of Thailand” National Reports on Wetlands in South China Sea First published in Thailand in 2008 by the United Nations Environment Programme. Copyright © 2008, United Nations Environment Programme This publication may be reproduced in whole or in part and in any form for educational or non-profit purposes without special permission from the copyright holder provided acknowledgement of the source is made. UNEP would appreciate receiving a copy of any publication that uses this publicationas a source. No use of this publication may be made for resale or for any other commercial purpose without prior permission in writing from the United Nations Environment Programme. UNEP/GEF Project Co-ordinating Unit, United Nations Environment Programme, UN Building, 2nd Floor Block B, Rajdamnern Avenue, Bangkok 10200, Thailand. Tel. +66 2 288 1886 Fax. +66 2 288 1094 http://www.unepscs.org DISCLAIMER: The contents of this report do not necessarily reflect the views and policies of UNEP or the GEF. The designations employed and the presentations do not imply the expression of any opinion whatsoever on the part of UNEP, of the GEF, or of any cooperating organisation concerning the legal status of any country, territory, city or area, of its authorities, or of the delineation of its territories or boundaries. Cover Photo: A vast coastal estuary in Koh Kong Province of Cambodia. Photo by Mr. Koch Savath. For citation purposes this document may be cited as: UNEP, 2008.