The NIH Record

U.S. Department April 27 National of Health 1982 Institutes and Vol. XXXIV of Human Services No. 9 Health

Dr. Martin Rosenberg NIH-Produced Film on Genital Herpes Wins Flemming Award Generates Considerable Public Interest Dr. Martin Rosenberg, chief of the cellu­ lar regulation section, NCI Laboratory of Recognizing the critical need for public Biochemistry, received the 33rd annual Ar­ education about genital herpes, the Office thur S. Flemming Award on Apr. 23 in of Research Reporting and Public Re­ Washington, D.C. sponse, National Institute of Allergy and The award was presented by Dr. Flem­ Infectious Diseases, and the NIH Audiovis­ ming, former DHEW Secretary (1958-1961), ual Branch have produced Jennifer: A Re­ and by Dr. Thomas E. Malone, Acting NIH vealing Story of Genital Herpes. This 28- Director. minute film shares the experience of a young woman striving to cope with her own case of genital herpes. Segments of this film have been tele­ vised on national network shows and also on local TV news and public service pro­ grams. Jennifer has been made available to physicians, health facilities, schools and In the film, Jennifer chats with Dr. Straus, civic groups on short-term loans. The re­ whose research group has successfully used sponse to initial promotional efforts has acyclovir to prevent recurrence of herpes virus been overwhelming. To date, more than infection. 500 loan requests from schools had to be edge and understanding of the signs and booked for the fall semester. symptoms of this disease, many people Infection with the virus causing genital with herpes unintentionally transmit it to herpes is on the upswing, reaching epi­ others. demic proportions. Due to a lack of knowl- (See JENNIFER, Page 9)

Dr. Rosenberg is internationally recognized as a Intramural Program Discussed During Congressional Visit leader in the use of recombinant DNA tech­ niques to investigate the complex and overlap­ Congressman Joseph D. Early, Massa­ eral staff members visited NIH recently to ping chemical regulatory signals controlling chusetts, member of the House Appropria­ gain a firsthand look at the facilities and gene expression. tions Subcommittee on Labor, Health and research program here, and to meet with The award is one of 10 presented annu­ Human Services, and Education, and sev- the scientific and Institute Directors. ally by the Arthur S. Flemming Awards Representative Early had requested a 1- Commission and the Downtown Jaycees day visit after reviewing a report on the in­ of Washington, D.C., to honor outstanding tramural program prepared by Fredette young men and women in the Federal West, an NIH management intern, who for Government. Award recipients are under the past several months has had an as­ 40 and work in scientific and administra­ signment in the congressman's office. tive fields. His tour was aimed primarily at learning Dr. Rosenberg was cited " . .. for his more about NIH's intramu ral program-its outstanding achievements in elucidating people, facilities, problems and needs. The the chemical basis of t he reg ulation of visit began with a meeting with Ors. gene expression, and his imaginative use Thomas E. Malone, Acting NIH Director, of that knowledge for the construction of and James Wyngaarden, NIH Director-des­ new biochemical tools that expand the po­ ignate. tential for investigating important genetic After meeting with them, the four-term questions . . . . " Or. James Hofrichter (in lab coat), of the representative from Worcester spent an He received the Ph.D. degree in 1972 Laboratory ol Chemical Physics, NIADDK, ex­ hour with the Board of Scientific Directors. from Purdue University. During his thesis plains how a transient spectrometer, that uses He was informed about the quality of in­ work, he invented a means of isolating two-pulse neodymium YAG lasers in studying tramural science at NIH; about the pro­ polynucleotides containing 2', 3'-diol the time-resolved structural evolution of gram's characteristics that attract top hemoglobin, is used. This high resolution piece moieties. This method is widely used for of scientific equipment was developed within scientists to it; and how current budgetary the isolation of specific transfer RNA mol­ NIH's intramural program. Others pictured are constraints are affecting programs, per­ ecules and for the isolation of the (from I to r) Dr. Wyngaarden, Kathleen M. Griffin, sonnel, and equipment. (See DR. ROSENBERG, Page 6) Ms. West, Jan Oliver and Congressman Early. (See VISIT, Page 7) The NIH Record

P1,,1bhsheo b1wee~ly at Bethesda, Md, by the Edttonat Operat,ons Branch. 01v1s,on of Public Information, ror the 1nto,ma11on ot employees of Hle Nar,onal Jnstrtuics o l Heal!h. Department ot Heallh and Human Services. and c11cu1a1ed by 1eauest to writers ano to ,esea,cners in b1omco,ca1 a.no rc1a1co l1clds The contc;>nt 1s rcor1n1ab:e w11hout oerm1ss1on Pictures rnay be

NIH Record Otltce Bldg 31 Room 26-03. Pt,one 496 212;

Editor Je,ry Gordon

S1all Wflters w,111am B Re1nct1.ens J oyce F McCartr,y

Staff Corres.ponde,lfs CC, Barbara smakula; DCAT W1lharn Hall; DPM, Jucsy Foucne: OAG, Sue Meadows; ORA, Barbara Men1ck. ORS. Jim Doherty, FfC, Susan P Slark; NCI, Patricia A Newman. NE! Ma,sna Corbett, NHLBI, Bill Sanrters; N1A Ann 0 1ef!enbaCl'l; NlAIO Jeanne w,nnick, NIAOOK. Barba1a W eldon. NICHO, Pamela The NIH National Nutrition Month activities during March were enthusiastically received. Attend· Onscofl: NIDA. Sal ly Wdberd1n9, NfEHS, Hugh J Lee, NIGMS ance and participation ware high al the many functions planned by the NIH Nutrition Coordinating Wanda W arddeU, NIMH, Harry Bell; NlNCOS, O,ane St11a.r, Committee, with the cooperation of various 81D's, the R&W Association, the Occupational Medical NLM , Roger L Gtlkeson Service, and the GSI Cafeteria Service. Above (c), former NIH Director (1950-55) Dr. W. Henry Sebrell was the "kickoff speaker'' to the series of events. Standing next to him (I and r) are: Karen A. Do­ nato, cochairperson of the NCC Subcommittee on Nutrition Education, and Dr. Artemis P. Simop­ Conference Will Be Held oulos, chairman of the NCC. Second row (I to r) are: Drs. David A. Wolff, cochairperson of the NCC Subcommittee on Nutrition Education, Thomas P. Vogl, NCC staff, and Zekin Shakhashiri, NINCDS On Research Lab Animal Use representative to the NCC. A national workshop on the Role of Ani­ mals In Biomedical Research will be held at the New York Academy of Sciences on 19 Different Health Plans Offered to Employees Apr. 28-30. During May 3-28 'Open Season' Period Funded by the Division of Research Re­ sources and the National Heart, Lung, and The Office of Personnel Management rely solely on the contents of the chart but Blood Institute, the ultimate purpose is to has announced an "Open Season" for May should review the total brochure of the inform both scientists and the public 3-28, under the Federal Employees Health plan for a complete description of bene­ about issues arising in the use of labora­ Benefits Program. fits. Copies of all brochures are available tory animals for research. During that period, eligible employees for review through personnel offices. In addition, the workshop will be geared may enroll in 1 of 19 different plans. Per­ to inform and educate the general public sons already enrolled may change their Conditions Outlined about the importance of animal research plan, option, type of enrollment, or any in scientific and medical progress, and the The Division of Personnel Management combination of these. The NIH Record concerns of scientists about the use of emphasizes some special items regarding issue of Feb. 2 carried details on rates and animals In experimentation. the open season: listing of plans available to NIH employ­ Dr. John E. Holman, ORR project officer • No transfer fee will be imposed on ees. for the workshop, advises that the pro­ persons who change plans during the Commissioned corps personnel, em­ ceedings will be published and made avail­ open season, ployees serving under appointments lim­ • Persons who change plans will not be able for distribution. □ ited to 1 year or less, and intermittent em­ required to meet a new deductible, but will How's Your Blood Pressure? ployees are not eligible for enrollment in be entitled to transfer the deductible from the FEHBP. the losing carrier to the new carrier. Any May is High Blood Pressure Month. The Eligible employees wiJI receive a packet covered expense incurred from 1/1/82 Occupational Medical Service invites all containing the 1982 enrollment information through 7/11/82 and applied toward the employees to have their blood pressure and plan comparison chart, 1982 Bi-weekly deductible for the losing carrier will be checked. Withholding Rates, and a copy of the gov­ credited toward the 1982 deductible for the In addition to the regular OMS health ernment-wide or comprehensive medical new plan, unit offices, screenings will be conducted plan brochure in which presently enrolled. • For persons who change plans, no throughout the campus, in the Federal, Employees covered by employee organi­ preexisting condition may preclude bene­ Blair and Westwood buildings. A desk-to­ zation plans will receive a 1982 brochure fits under the new plan, and desk notice has been distributed indicat­ directly from the sponsoring organization. • The effective date of enrollment or ing specific locations. change in enrollment will be July 11. For further information, call 496-4411. □ Comparison Charts Provided After reviewing the literature, eligible Mail Registration Needed The comparison chart gives the major employees who wish to enroll or to change features of all plans. It assists employees enrollments should contact their BID reg­ For Nuclear Symposium in selecting the plan most suited to their istration assistant and obtain a Health NIH employees who plan to attend the needs. Benefits Registration Form. The names symposium on the Medical Consequences The booklet also outlines the four types and locations of the assistants are listed of Nuclear Weapons and Nuclear War, Lis­ of plans available. It itemizes major cate­ on official bulletin boards. ner Auditorium, George Washington Uni­ gories of coverage such as catastrophic Personnel offices are in the process of versity, on Tuesday, May 11 , should mail protection, doctor visits, dental, mental distributing materials on the open season their registration forms in prior to attend­ health, maternity and emergency care, at this time. Employees may contact them ing. Forms may be obtained at the FAES outpatient diagnostic tests, etc. for program information. □ Bookstore in Bldg. 10. □ The OPM requests that employees not

Page2 The NIH Record April 27, 1982 Gaza Strip Study Is Basis Music, Dance, Art To Be Featured During For International Workshop Asian Pacific Heritage Week in May A 3-day international workshop on The Influence of the Environment on Leukemia and Lymphoma Subtypes will be held in ~~-~ Bldg. 31, Conf. Rm. 10, on May 5-7. The workshop originated from a series ~ of discussions between Or. Bracha Aamot, a Fogarty scholar-in-residence, and Dr. Ian Magrath, a visiting scientist in the Pediat­ ric Oncology Branch, NCI. Dr. Aamot has observed a remarkable change in the pattern of leukemia and lym­ phoma subtypes in the Gaza Strip Arabs. These patterns were associated with a dramatic increase in socioeconomic con­ ditions. The high ratio of B-cell to T-cell lymphoid neoplasms were completely re­ versed as affluence increased, according to the research done by Dr. Aamot. This, coupled with information on the epidemiology of acute lymphoblastic leu­ kemia, led Ors. Aamot and Magrath to pro­ pose a hypothesis that the environment has a major role in determining the pre­ dominant type of lymphoid malignancy.

Hypothesis Published Details about this hypothesis were pub­ lished in the British Journal of Hematol­ Love for Young and Old is this year' s theme at NIH for Asian Pacific American Heritage Week. This poster of an old Chinese man and a child is the sixth cultural theme done by Medical Arts artist ogy, February 1982. After further discus­ Alfred C. Laoang. sions with Dr. Greg O'Conor, director of the Office of International Affairs, and Dr. This year's Asian Pacific American Heri­ /ected from the audience. Robert Miller, chief, Cl inical Epidemiology tage Week, May 12-14, will have lunchtime On Friday, May 14, from 7:30 until 10:30 Branch, NCI, it was decided to propose activities featuring traditional arts and p.m. in the Masur Auditorium, Bldg. 10, this workshop in order to obtain more in­ crafts booths, and films about different performances will be offered by cultural formation regarding the spectrum of lym­ countries. As in previous years, the activ­ groups from India, China, Vietnam, In­ phoid malignancy in populations living in ities will culminate with a Friday evening donesia, and Cambodia. quite different environments. cultural program, May 14. The Bharathnatyam-a 4,000-year-old The workshop will bring together clini­ NIH employees and the general public temple dance from southern India wi II be cians, epidemiologists, immunologists, vi­ are invited to all of these events. Admis­ done, along with classical choral music; rologists, and pathologists from 12 coun­ sion ls free. Films on Bali, Indonesia, and the Fork Dance from the Gujarati dis­ tries to discuss the differing patterns of Japan, China, Singapore and Malaysia will trict will also be performed. lymphoid malignancy throughout the be shown daily from 11:30 a.m. to 1:30 p.m. The Tien Yun Chinese Youth Orchestra world, and to develop new collaborative in Bldg. 31 's Visitors Center. will play Chinese and Asian folk music. studies to investigate the reasons for There will also be a demonstration of Patio To Be Used these differences. board breaking by members of the Chuei The workshop will be jointly sponsored Traditional arts and crafts will be dis­ Ju School of Martial Arts. by F!C and NCI. Preregistration is required played in booths set up in Bldg. 31's patio The traditional Vietnamese Fan Dance and may be arranged by contacting Nancy and will feature such countries as Japan, and a folk dance depicting the Legend of Shapiro, 496- 2517. □ Cambodia, China, Malaysia, India, and the Betel will be executed by the Viet­ Burma. In case of rain, they will be moved namese Mutual Association's dancers. into the Visitors Center. Both Balinese and Javanese dances de­ On-lookers will see lkebana, the Jap­ picting ancient warrior epics will be per­ Training Tips anese art of flower arrangement done by formed by Indonesian artists. The following courses, sponsored by the members of the metropolitan lkenobu Khmer Dancers Featured Division of Personnel Management, are school. given In Bldg. 31. An explanation and demonstration of The 1,200-year-old dance tradition of traditional Japanese art will be given. For­ Cambodia will be seen with the per­ Communication Course Deadline tunate spectators might even have their formance of two folk dances done by the Skills Starts names printed in caligraphy. Khmer Classical Dance Troupe, some of Report Writing 6/1 5/3 Chinese brush painting, kite making, whom had danced with the Royal Ballet of Workshop and paper folding, along with a session on Cambodia. Writing Workshop 5/24 5/6 Chinese cooking, will also be featured. The purpose of the 10th annual NIH Principles of 6/2 5/18 Wood and stone carvings from Cam­ program is to give visibility to the contri­ Editing bodia; Burmese arts and crafts; artifacts butions made by Asian/Pacific Americans To learn more about these and other from Malaysia and Singapore; and con­ to the rich cultural diversity of the United courses in office and communication temporary handicrafts and reproductions States. skills, contact the Training Assistance of 17th and 18th century miniature paint­ The week's activities is being sponsored Branch, DPM , 496-2146. ings from India will also be on view. by the NIH Asian American Cultural Com­ Sari-wrapping from India-the art of mittee in collaboration with NIH's Division turning a piece of cloth into a full-length of Equal Opportunity. For further infor­ The only old person is he or she who no dress with shawl-will also be shown. mation about activities contact Dr. Yoke P. longer desires to learn.-Ugo Ojetti □ Models for this demonstration may be se- Loh, committee chairman, 496-3239. 0

April 27, 1982 The NIH Record Page3 material, of bacteria. As the bacteria mul­ Synthetic Growth Hormone tiply, they produce large amounts of hu­ man growth hormone. Being Tested in NICHD Studies Preliminary tests in animals showed synthetic growth hormone to be nontoxic In one of the first medical applications and as effective as natural hormone in of recombinant DNA research, doctors at stimulating growth. The safety of the syn­ the National Institute of Child Health and thetic hormone in humans was demon­ Human Development and nine other medi­ strated this past fall in a test involving a cal centers are testing synthetic human group of normal, healthy adults. growth hormone in patients with growth The effectiveness and safety of synthe­ hormone deficiency. tic growth hormone in children with About 20,000 children in the United growth hormone deficiency is now being States fail to grow at a normal rate be­ tested in patients at NICHD and nine med­ cause they do not produce enough growth ical schools. A total of two dozen children hormone. This hormone, made by the pitui­ throughout the country will receive the tary gland, is the body's main growth-pro­ !hormone during these trials. moting agent. Researchers will compare the growth In most cases, growth hormone deli­ rates of the children to those achieved in ciency occurs for no obvious reason. 1he past with natural hormone. If all goes Among the known causes are tumors, in­ well, synthetic growth hormone may be fection, radiation to the head, and head available commercially within 2 to 3 years. injury. The disorder can also be inherited. The biggest impact of synthetic growth The patient being treated at NICHD ap­ hormone will be in overcoming the parently lost the ability to make sufficient shortage of the hormone for research and growth hormone as a result of an accident medical treatment, says Dr. Barry Bercu, a 4 years ago in which she fell and hit her ped iatric endocrinologist at NICHD. head. Until that time, her father recalls, This picture is typical of a human growth hor­ With unlimited supplies of growth hor­ she and her identical twin sister had al­ mone study in which a doctor measures the mone now becoming available, research­ ways been the same height. growth progress of a petite 4-year-old treated for ers can try the hormone in children who a pituitary gland deficiency. After the accident, the patient's growth are short for reasons other than growth slowed, while her sister continued to grow fore been scarce. hormone deficiency-a population esti­ at a normal rate. Today, at age 12, she is 4 The synthetic growth hormone now mated at 100,000 in the United States. feet 3 inches tall, 4 inches shorter than her being tested is a product of genetic engi­ NICHD is planning a study this spring, sister and below normal for her age. neering, a technology developed only 9 Dr. Bercu said, in which synthetic growth Treatment for growth hormone defi­ years ago. hormone will be tested in children who are ciency consists of replacing the hormone. Scientists at Genentech Inc., a south short for various reasons, including de­ Until now, the only source of human San Francisco research firm, prepare the layed puberty and an inherited tendency growth hormone has been the pituitary hormone by inserting the human gene for toward shortness. glands of cadavers. Supplies have there- growth hormone into the DNA, or genetic -Susan Johnson·

South Koreans Award Dr. Liljeroot Dies, NICHD Science Administrator Gold Medal to Dr. Popper He transferred to NI CH D's Population Dr. Hans Popper, a world renowned au­ and Reproduction Grants Branch of the thority on liver disease and a former long­ Center for Population Research in 1969. time grantee of the National Insti tu te of There he was responsible for reviewing Arthritis, Diabetes, and Digestive and Kid­ and evaluating progress made by research ney Diseases for many years and other In­ training grantees in population and repro­ stitutes, was recently presented the South ductive sciences. He also served for Korean Order of Civi l Merit, Mungunghwa several years as the executive secretary of Medal, by President Chun Doo-hwan. the reproductive and perinatal biology training review committee. Highest Award for Civilians Having graduated from Upsala College in 1948, Dr. Liljeroot's academic experi­ The Mungunghwa Medal, a gold medal ence included teaching at both high featuring the South Korean national school and college levels, lecturing in flower, the Rose of Sharon, is the highest physiology at Rutgers University and chair­ award that may be given to civilians by the ing the science department of Newark government of South Korea. Dr. Popper is Academy in New Jersey. He also served as the first foreign medical expert to receive an independent re~earch chemist with the the honor. American Cyanamid and Westinghouse An honorary professor at Mt. Sinai Dr. Bengt S. Liljeroot Electric Corporations. School of Medicine in his eighties, and for­ mer president of the International Associa­ Dr. Bengt S. Liljeroot, health scientist He received his M.S. from Lehigh Univer­ sity in 1950 and his doctorate in 1964. tion for the Study of Liver Disease, Dr. administrator with the Reproductive Popper began helping South Korea in 1961 Sciences Branch of NICHD's Center for Dr. Liljeroot is survived by his wife Ker­ by supplying $20,000 worth of regents and Population Research, died Mar. 13 at his stin, their daughter Cecilia Liljeroot-Whit­ apparatus to the Republic of Korea Army home. man and a son Christian, all of Bowie, Md.; Liver Research Unit. Entering Federal service at NIH in 1966, his parents Mr. and Mrs. Sture Liljeroth, a Si nee then, he has continued to support Dr. Liljeroot worked in the Health Re­ brother Peter and sister Mona Schulz, all medical programs in South Korea where of Sweden. search Facilities Branch, Division of Re­ various diseases such as cancer of the search Facilities and Resources. He as­ Expressions of sympathy may be made liver and hepatitis have prevailed as in sisted in the scientific review of grant to the Liljeroot Memorial Fund, Trinity other developing countries. □ applications for construction of health and Lutheran Church, Laurel-Bowie Rd., Bowie, mental retardation research facilities. Md. 20715.

Page4 The NIH Record April 27, 1982 NIEHS Uses Mass Spectrometers Extensively Dr. E. G. Trams, NINCDS, Dies in Plane Crash For Analyzing Environmental Chemicals Dr. Eberhard G. Trams, 56, chief of The laboratory looks something like the NINCDS's physiology and metabolism sec­ inside of a submarine, packed with high tion, Developmental and Metabolic Neurol­ technology instruments and busy people, ogy Branch, died Mar. 28 in a plane crash. The private single-engine plane in which recognizable computer terminals and less he was traveling crashed shortly after familiar clusters of electronic gear. The takeoff from a Westminster, Md., airport. scene is in the Analytical Chemistry Group laboratory of the National Institute of Envi­ Dr. Trams had been with NIH since 1958 ronmental Health Sciences. when he worked as a biochemist in the The "stars of the technological show" section on lipid chemistry of the National are four mass spectrometers, instruments Institute of Neurological Diseases and that can identify and determine levels of Bl indness, the predecessor of NINCDS. He chemical concentrations in samples as became chief of NINCDS's section on small as parts per trillion. physiology and metabolism in 1976. Although each instrument has its own Throughout his career, he traveled the personality and appearance, the spec­ U.S. and abroad as a visiting scientist and trometers are all made of polished lecturer. In he was a National Aca­ 1971, stainless steel, many control knobs and demy of Sciences exchange scholar to switches, and a complicated collection of Ors. Carol Parker (I) and Ron Hass conduct tests Eastern Europe. connecting wires. The ticking of vacuum in their NIEHS laboratory while developing new Before coming to the NIH, Dr. Trams pumps and the gentle whine of cooling instrumentation. held several positions at the George Wash­ fans combine to form their sounds. ington Un iversity School of Medicine, in­ of a Federal regulatory agency. In another There seems to be a rapport between cluding a faculty appointment in the de­ instance, they analyzed samples of ortho­ the scientists and the electronic devices chlorophenol for dioxins after a railroad partment of pharmacology. similar to that between musicians and He received his Ph.D. in physiology and accident caused a chemical spill in their musical instruments- part harmony Missouri. pathology from George Washington Uni­ versity Graduate School, and attended the and part negotiation- as problems are "These situations demonstrate the crit­ University of Berlin Medical School. traced and results pursued. ical importance of accuracy," Dr. Hass The group has adapted each of the four said. "A mistake in the identification of a According to Dr. Roscoe 0. Brady, chief spectrometer systems to perform different contaminant may lead to inappropriate ac­ of the Developmental and Metabolic Neu­ specialized applications. Each system has tion in response to a problem." rology Branch, Dr. Trams conducted exten­ what for a layman is a somewhat awe-in­ In many cases, mass spectrometry pro­ sive and impressive research on cell com­ spiring name: ultra high resolution mass vides the only technology currently avail­ munication at the biochemical level. Much spectrometer; high resolution mass spec­ able with the capability to identify envi­ of his most recent work involved the study trometer; tandem quadrupole mass spec­ ronmental chemical residues retained in of enzymes on eel I surfaces- ectoen­ trometer system; and the combined high the body from either one-t ime exposures zymes. pressure liquid chromatography system. or long-term, low-dose exposures that may He discovered a new cell product­ The capabilities of these instruments cause disease. exosomes-which are small packets of are staggering to the imagination. An ex­ As the group's reputation has spread at cell membranes that contain enzymes. ample of their highest performance can the Institute, it has been involved in three Exosomes exfoliate from the surface of distinguish molecules which differ by one major activities: support io biomedical re­ cells and appear to mediate a form of in­ part in a million. By appropriate sample search in areas as diverse as pharmacol- . tercellular communication. manipulations, analysis of impurities at ogy a.1d reproductive and developmental Dr. Trams also studied the phylogeny of the part-per-trillion level can be performed. toxicology; development of analytical neurotransmitters in the brain. His most Chemicals are introduced after evap­ teGhniques; and basic research in spec­ recent work was on the biochemistry of oration into the high vacuum system into trometry itself. manic depressive psychosis. the ion source reg ion of the instrument. With these multiple assignments, the "He was a very busy scientist," said Energy is added, converting sample mole­ group currently has to limit its efforts to Dr. Brady, "who had an outstandingly fer­ cules into changed ions. These are then analysis in support of research conducted tile and productive imagination." subjected to various electric and magnetic within the lnstitute's own laboratories. A memorial service for Dr. Trams is ten­ 1ields which separate the ions on the basis They can therefore accept no samples for tatively scheduled for sometime in late of their mass per unit charge. analysis from outside sources that fall May. For details, contact Corinne Gillis, The goal of the group, as with the Insti­ 496-5468. outside the boundaries of their existing re­ tute, is to provide and support the basic search involvements. During a typical year, research to identify agents of environ­ the NIEHS spectrometers have each been mental concern, how they are handled, used for as many as 2,500 sample runs. NIH Federal Credit Union stored and eliminated by the body, the The particular spectrometry system se­ Elects 1982 Board of Directors specific organ or system they affect, and lected to analyze a sample depends on the the diseases they cause. Learning this chemical's composition as well as the in­ New officers were recently elected to then facilitates planning for proper han­ formation that the researchers are trying serve on the 1982 board of directors for dling and control, and assists in the to learn about the chemical. The group is the NIH Federal Credit Union. prevention of environmentally related now modifying one component of its spec­ The new directors are: president, Dr. diseases. trometers, the ion source, to be able to Normand R. Goulet, NIH's regional coordi­ Though most work can be described as use a method called fast atom bombard­ nator, Office for the Protection From Re­ research, the group has performed routine ment, or FAB for short. search Risks; vice president, Otis Ducker, analysis in response to a number of envi­ " With FAB we hope to be able to ionize Director, Division of Administrative Serv­ ronmental catastrophes. For example, larger molecules to enable us to look at ices, Office of Research Services; secre­ when a chemical warehouse exploded in higher molecular weights," Dr. Hass ex­ tary, Donald F. Cypers, financial manage­ New Jersey, Dr. Ronald Hass, head of the plained. "We'd like to be able to work with ment officer, National Institute of Arthritis, ACG, and his staff, determined the amount smaller pieces of tissue samples and de­ Diabetes, and Digestive and Kidney Dis­ of the potentially poisonous dioxins that tect and identify chemicals at even lower eases; and treasurer, Robert S. Dickenson, were capt ured in air-monitoring equipment concentrations," Dr. Hass said. Office of Grants and Contracts, ORR. □ - Thomas Hawkins D

April 27, 1982 The NIH Record Pages DR.ROSENBERG Firemen Complete Physical Assessment Program (Continued from Page 1)

5'-terminal regions of "capped" eukaryotic messenger RNA's. He became a postdoctoral fellow at Yale University from 1972-1974, where he stud­ ied the regulation of gene transcription in E. coli bacteria and conducted studies that led to new understanding of the matura­ tion of early phage messenger RNA. In 1974, Dr. Rosenberg became a staff fellow in the NCI Laboratory of Molecular Biology. In 1976, he was appointed re­ search chem ist, senior staff investigator there. Late in 1979, he moved to the Labo­ ratory of Biochemistry, and became chief of the cellular regulation section. In this position, he directs studies on the regula­ tion of gene expression in both bacterial and animal cells. Fireman Paul E. Davis has his body weight hy­ He has constructed bacterial vectors for Sometimes NIH firefighters are required to enter infernos, even during training. drostatically measured. recombinant DNA research on the produc­ tion of cellular proteins. For the last 3 years, members of the NIH In addition, as part of the program, each His work on the finely tuned mecha­ Fire Department have participated in a fireman is given a cardiac risk profile nisms that regulate the mode of action of confidential physical fitness assessment which permits a self-evaluation based on a bacterial virus made possible the isola­ program designed to determine their over­ the information obtained. It could ind icate tion of a powerful regu latory protein of the all physical and cardiovascular condition. what the probability of a heart attack or virus. This technique is now being applied Knowing their physical capacity is par­ other cardiovascular disease. to the isolation of rare cellular .proteins ticularly important to these men whose oc­ One measurement taken was to ascer­ found in cells transformed by animal cupation nationally has a 50 percent dis­ tain how well the body reacted to stress tumor viruses. ability rate due to heart attack. created on a graded treadmill. Each fire­ Dr. Rosenberg has participated in teach­ Recently, NIH firemen, whose ages man ran for a certain period of time while ing workshops sponsored by international range from the mid twenties to the late for­ EKG, blood pressure and heart rate were scientific societies. He has chaired sympo­ ties, completed the final phase of their as­ recorded. sia at meetings of the European Molecular sessment program at the Institute of Hu­ Body composition, or the amount of fat, Biology Organization and the American So­ man Performance, in Fairfax, Va. At the was measured by submerging each fire­ ciety of Biological Chemists. conclusion, each firefighter received a man in a tank of water to get a compari­ He has been elected chairman of the computer printout of his performance dur­ son of total body fat. 1983 Gordon Conference on Biological ing the various laboratory tests to measure For the test, firemen did stretching exer­ Regulatory Mechanisms . □ physiological capacity. cises, repeated several strenuous broad­ IHP is the testing service which Mont­ jumps, did pushups, pu lled down and up gomery County police, fire, and sheriff's on heavy weights, and had their feet Feeling at Home in the U.S.A. departments have used. They have also bound to the ground to see how many sit­ done evaluations for the U.S. Department ups they could do in 2 minutes. People coming from outside the U.S. of­ Indices and recorded capacities for a ten view this country as a giant maze. To of Justice and the U.S. Marine Corps. particular exercise relating either to mus­ assist those In the NIH community to ma­ Over the last few years, more and more cular strength, endurance, power, flexibil­ neuver effectively in a variety of situations private businesses and government agen­ ity, or aerobic capacity were taken. characteristic of American life, the R&W cies have turned to such services as pro­ Association will be offering a series of vided by IHP to prevent the premature re­ At the conclusion of each test cycle workshops, Feeling at Home in the U.S.A. tirement of employees due to disability, over the last 3 years, IHP furnished the Consisting of 10 weekly sessions, the according to Dr. Paul 0 . Davis, an exercise NIH firefighters with a record of their phys­ workshops will address a variety of issues. physiologist who was director of testing ical capacities along with a suggested They will be conducted by Susan Keith services for the Sports Medicine Center at physical fitness regimen tailored to each and Lucy Shahar, experienced intercultural the University of Maryland for 4 years. man's previous perform ance and personal trainers, both of whom have I ived in for­ " There has become a strong need for needs. eign countries. addressing the physical assessment of in­ " Regardless of whoever is tested in Ms. Keith and Shahar will preview work­ dividuals in the fire and police service," such a program, it's extremely important shop content at Bldg. 31, Cont. Rm. 4, on says Dr. Davis, president of IHP. His staff that people in this job be physically fit," Monday, May 17, from 5:30 to 6:30 p.m. evaluates each participant to determine said NIH Fire Chief William F. Coleman, and on Tuesday, May 18, from noon to 1 how well they perform as compared with who noted that many of the firefighters are p.m. the physical occupational standards estab­ now going into spring training to follow up Spouses are encouraged to attend. □ lished by IHP. on IHP's suggested program. □

Spend a Fun Day at Kings Dominion Federal Employment Application Program Available Kings Dominion is located 75 miles How to Apply for a Job, an individual also available for hearing impaired employ­ south of Washington, and 20 miles north learning program designed to assist em­ ees. of Richmond, Va. The park offers rides, ployees in applying for a Federal job, is Such topics as hints about vacancy an­ shows, Scooby Doo, Yogi Bear, and a dol­ now available from any BID personnel of­ nouncements; a brief explanation of the phin and sea lion show. fice or EEO office. application process; how to fill out an Tickets are available at R&W Activities The instructional package consists of a SF-171 Personnel Qualifications State­ Desk, Bldg. 31, Rm. 1A- 18.D 25- minute audiocassette tape and work­ ment; and advice on interviewing are cov­ book. A written version of the materials is ered in the program. □

Page& The NIH Record April 27, 1982 VISIT (Continued from Page 1)

After the discussions, Congressman Early was accompanied by Ors. Wyn­ gaarden, Philip S. Chen, Jr., NIH Assistant Director for Intramural Affairs, and Ken­ neth W. Sell, scientific director, National Institute of Allergy and Infectious Dis­ eases, to observe research in Bldgs. 8 and 7. While there, Congressman Early and staff met with members of the Laboratory of Parasitic Diseases and the Laboratory of Infectious Diseases, NIAID. He also learned about the planned laboratory reno­ vation program involving these older bu ildings. A noontime luncheon was hosted by Or. Richard N. Krause, Director, NIAID, at his residence. Later, the congressman visited A 15-member delegation from the Pan American Health Organ ization met recently with NHLBI staff with Dr. William A. Eaton, chief, section on to discuss plans tor cooperative efforts among scientific institutions in South America and the macromolecular biophysics, NIADDK, in Caribbean. The discussions focused on prevention and control of cardiovascular disease with spe• cial emphasis on the nutritional aspects of these diseases. The PAHO delegation, consisting of members from Brazil, Chile, Ecuador, Jamaica, Mexico, and Trinidad, were in Washington to attend a meeting on the Contribution of Dietary and Pharmacological Interventions in the Prevention and Control of Chronic Cardiovascular Diseases.

International Health Discussed During Dialogue in Washington

The Un ited States, particularly the U.S. ternational Health; Thomas E. Malone, Act­ Public Health Service, maintains an inter­ ing NIH Director; and Claude Lenfant, Di­ est in world health problems. Under multi­ rector, FIC. lateral programs with the World Health Or­ Dr. Lenfant emphasized that no country ganization, the PHS has contributed to dis­ is immune from disease and that the ease prevention and health maintenance spread of disease is a continual problem. worldwide. In recent times, he noted that influenza Cooperative projects with other coun­ originating in Asia spread to the Americas Nobel laureate Dr. Axelrod (I) and Dr. Frederick tries, either through formal bilateral agree­ K. Goodwin, scientific director, NIMH (c), confer and Europe. Previously, he added, in the with Congressman Early during his tour. ments or through informal ties, improve 19th century, cholera from Asia also the health of the people both in the United spread throughout the world. Bldg. 2. This section has for the past States and other countries by sharing re­ Dr. Malone, discussing international co­ several years been studying the basic sources and costs. operation in tropical medicine, cited the structure of the sickle cell which besides These were some issues that were dis­ special priority given by National Institute its original intent has scientific implica­ cussed during the Dialogue in Interna­ of Allergy and Infectious Diseases to filari­ tions for many other areas. tional Health held on the evening of Mar. asis, leishmaniasis, leprosy, malaria, Ors. Mortimer B. Lipsett, Director, Cli ni­ 11 at the International Club, Washington, schistosomiasis, and trypanosomiasis. cal Center, and Jack Orloff, scientific di­ D.C. He observed that in recent years, the rector, National Heart, Lung, and Blood In­ Organized by the Fogarty International proliferation of bilateral agreements with stitute, met Congressman Early at the Center, the dialogue was led by Dr. Ed­ developing countries has led to increased entrance to the new Ambulatory Care Re­ ward N. Brandt, Assistant Secretary for cooperative activity in tropical diseases re­ search Facility. During his tour, the repre­ Health, HHS, and a panel consisting of search. □ sentative and his staff witnessed an open­ Ors. John H. Bryant, Director, Office of In- heart surgical procedure. The congressional visitors were also taken to a pediatrics ward; observed how NIEHS Personnel Honored the computerized Medical Information Sys­ tem keeps accurate statistics on patients For EEO Efforts at Meeting and aids in their care; and viewed how a The National Institute of Environmental PET scanner in the Nuclear Medicine De­ Health Sciences recently hosted the an­ partment reflects the metabolic activity of nual installation meeting of the North Ca­ the brain. roli na Association of EEO Personnel, with Also, the congressman spent time with Norman Eubanks, NIEHS EEO officer pre­ Nobel laureate Dr. Julius Axelrod, chief, siding. section on pharmacology, Laboratory of At the meeting Mr. Eubanks, who has Clinical Science, NIMH, and Dr. Phi llip served three terms as association chairper­ Gorden, clinical director, NIADDK. son, and newly elected chairperson Frank Toward the end of the day, Congress­ Evans, EEO officer at Cherry Point Marine man Early met with the BID Directors in Air Station, presented award certificates to the CC Medical Board Room. He closed two NIEHS staff members. The circus comes to the NIH Toastmasters Club his tour by visiting with Dr. Alan Rabson, Dr. William W. Lawrence, NIEHS employ­ where Jerry Gordon, OD, acts as barker to intro· director, Division of Cancer Biology and duce "Fiddle-Dee-Dee," clowned by Gil Wright, ees counselor, and Alvin L. Wade, Jr., NHLBI. Diagnosis, NCI, and seeing the NCI Cen­ NIEHS personnel officer, received awards tral Animal Facility on the B2B W ing. □ for their active support in pursuit of equal Instead of lovi ng your enemies, treat employment opportunity goals. □ your friends a little better.- E. W. Howe □

April 27, 1982 The NIH Record Page 7 JC Virus: A Brain Tumor Model Dr. McConnell Receives Linked to a Rare Disease 1982 Dickson Award Dr. Harden W. McConnell, a grantee of Chances are that lurking somewhere in Clinical symptoms of PML result from the National Institute of Allergy and Infec­ your blood are antibodies for a virus called the JC virus's infection of the oligoden­ tious Diseases, received the 1982 Dickson " JC." Scientists have detected these anti­ droglla cells. These cells make myelln, a Prize for Science from Carnegie-Mellon bodies-the only evidence of an unrecog­ fatty covering that insulates the axon or University in Pittsburgh, Apr. 3. nized, prior short-term infection by JC-in trunk of the nerve cell, and assists in the The prize honors persons in the United 84 percent of the U.S. population. flow of messages sent along nerve fibers. States who have made an outstanding The National Institute of Neurological When the oligodendroglia are infected, contribution to the field of science. It was and Communicative Disorders and Stroke the myelin is destroyed in a process called established in 1969 through funds provided is studying JC because-for a small, un­ demyelination that leads to the onset of in the wills of Pittsburgh physician Joseph lucky group-the virus persists in the symptoms. z. Dickson and his wife, Agnes Fisher Quite often the PM L patient first ap­ Dickson. pears to be a classic stroke case; but as Or. McConnell, professor of chemistry at the disease progresses, many areas of the Stanford University, was presented a nervous system are involved. Eventually $10,000 check and a bronze medal for "his the patient becomes blind and demented. contributions to the development and ap­ Death usually results from infection. plication of magnetic resonance tech­ Many PML patients have giant multlnu­ niques to chemical biological problems, cleated astrocytes (cells that make up the and for his more recent contributions to supporting structure of nervous tissue) in the fields of membrane biophysics and cel­ their brains. These astrocytes have some lular Immunology." malignant characteristics. During the award ceremony, he delivered Although several PML patients have also the Dickson Prize lecture, Interfaces Be­ developed a type of cancerous brain tumor tween Physics, Chemistry, Biology and called an astrocytoma (grades 3 and 4 Mathematics. which are the most deadly kind); it is still Dr. McConnell and his colleagues are not known whether the JC virus can cause preparing reconstituted membrane vesi­ malignant tumors in man. Research is cles-"synthetic cells" having precisely under way to evaluate this possibility. defined chemical compositions and physi­ The JC virus has produced grade 3 and 4 cal properties. astrocytomas in some nonhuman pri• These cells are designed to mimic real mates. Primates inoculated with JC virus biological cells in respect to their highly Dr. Sever moderated the Slow Virus Science who do not develop tumors may be pro­ Writers Seminar. He opened the meeting with a specific interactions with other cells. brief explanation of the different persistent viral tected from disease by their immune sys­ His synthetic cells are simple and con­ infections under study by NINCDS scientists. tems, said Dr. William C. Wallen, chief of tain a small number of distinguishing mol­ the viral immunology unit. ecules (virus proteins, transplantation body, eventually causing a rare neurologi­ Dr. Wallen said he hopes that research antigens, etc.) that may be recognized as cal disease. JC's other ability to cause on the role of immunity In monkey tumor foreign by an immune system. brain tumors in animals provides one of growth will lead to the discovery of viral According to Dr. McConnell, " We are us­ the few model systems for the study of vaccines and tumor-related antigens that ing the most sophisticated techniques of brain tumors in primates. would prevent tumors. physics and chemistry to try to discover At a recent NIH science writers' semi­ Another possible benefit of the JC tumor how the immune system decides, at the nar, NINCDS Infectious Diseases Branch model research, according to Dr. William molecular level, whether a given (synthetic) chief, Dr. John L. Sever, and six scientists T. London, chief of the experimental path­ cell is 'friend' or 'foe' and how the chosen discussed current research on the biology ology section, is the development and enemies are killed. of the JC-induced primate tumor, ways to evaluation of diagnostic tests for human "In a human," he explained, " the vitality diagnose the tumors, and progressive mul­ use. and success or fai lure of these molecular tifocal leukoencephalopathy (PM L)-the Dr. London, who is conducting research signals is the difference between life and rare disease caused by JC. on owl monkeys inoculated with the JC vi­ death." The virus was first isolated in tissue cul­ rus, noted that contrast-enhanced com­ Dr. McConnell was elected to the Na­ ture in 1971 when it was named for a PML puted tomography (CT) allows for the de­ tional Academy of Sciences in 1965, and patient whose initials were " JC." tection of tumors while the animals are this year was elected a fellow of the Amer­ "Primary Infections with JC virus occur still clinically normal. ican Association for the Advancement of early in life in the majority of the popula­ Like time-lapse photography, CT scans Science. tion," said Or_ Sidney A. Houff, clinical of monkey brains over severa l days show Born in Richmond, Va., he received the neurologist with the NINCDS ln!ectious the rapidly developing tumors and such S.S. degree from George Washington Uni­ Diseases Branch. The symptoms of this characteristics as tissue death and hemor­ versity in 1947 and the Ph.D. from the Cali­ primary infection and when it occurs are rhage-even though the monkeys appear fornia Institute of Technology in 1951. He still unknown. to be healthy. Similarly, CT scans of hu­ joined the Stanford faculty in 1964, and Years later, JC can strike again-this man brains are being used to predict path­ was named Robert Eckles Swain professor time in the form of PML. People whose im­ ological changes in a tumor. of chemistry in 1979. □ mune systems are weakened by cancer, Other aspects of JC viral research were autoimmune diseases, or the use of immu­ presented at the science writers' seminar Visit The Old Country! nosuppressive drugs after organ trans­ by Dr. Eugene Major, a visiting scientist plants are the most common targets of with the viral immunology unit, and Dr. The Old Country, Busch Gardens, Wil­ PML. Nancy Miller, an expert consultant to the liamsburg, offers rides, shows, featured at­ It is uncertain whether PML patients are unit. In addition, Dr. Clarence J. Gibbs, Jr., tractions and exhibits. The Loch Ness experiencing a reactivation of the latent deputy chief of the Laboratory of Central Monster is a twisting, turning, 300-ton JC infection or are having an unrecognized Nervous System Studies, discussed trans­ double-looped roller coaster claimed by primary infection, according to Dr. Houff. missible dementias and hemorrhagic fe­ many to be the scariest ride in America. The role of the patients' deficient Immune vers with renal syndrome. Tickets can be obtained at R&W Activi­ system in the development of PML ls un­ - Diane Strlar□ ties Desk, Bldg. 31, Rm. 1A- 18. □ clear too, he said.

Page8 The NIH Record April 27, 1982 Dr. Karl A. Piez Retires From Dental Institute JENNIFER Dr. Karl A. Piez, chief of the NIDA Lab­ The researchers also demonstrated that (Continued from Page 1) oratory of Biochemistry since 1967, retired collagen is synthesized in a precursor form It is estimated that 15 to 20 million peo­ Mar. 31 after more than 30 years of service and that the precursors are distinct for the ple are afflicted with this chronic, incur­ at NIH. He has accepted a position as di­ various collagens. able infection, a number growing more rector of research and development for the Most recently, Dr. Piez has shown that than 500,000 a year. Genital herpes can be Collagen Corpora­ chemical features inherent in the collagen a recurrent, painful, lifelong condition. Not tion in Palo Alto, molecule itself may determine the struc­ only does it affect an individual physically, Calif. ture of the fibril that forms as the mole­ but psychologically as well, often causing Since 1951, he cules aggregate. depression, marital conflicts, and disrup­ has carried out or He will be concerned with developing tions in social and sexual relationships. directed studies at collagen for medical uses while working at Jennifer takes the viewer through the NIDA elucidating the Collagen Corporation. One product, a emotional experience of an individual the structure of highly concentrated solution of collagen, learning she has genital herpes, and what many connective is currently approved for clinical use to she can do about it. Admitted as a patient tissues. He correct dermal defects. On injection, the in the Clinical Center as a participant in a described the collagen assembles into collagen fibers special research project, Jennifer meets chemical structure which can restore normal tissue architec­ Dr. Stephen Straus, NIAID, chief, Medical of collagen and de- ture. Virology, and Susan Bachrach, R.N., Clini­ veloped many Dr. Piez Dr. Piez began work at NIDA in 1949 and cal Center nurse practitioner. methods used in the connective tissue then attended Northwestern University Through conversations with Dr. Straus field. where he completed his Ph.D. He has and Ms. Bachrach, Jennifer begins to un­ Dr. Piez and his associates showed that worked at NIDA since 1951, where he derstand the nature of the disease and to collagen, the major structural protein in served as a research chemist, chief of the come to grips with her anger and psycho­ skin, bone, tendon, etc., is a long rigid, protein chemistry section, and later chief logical turmoil. rod-like molecule which, linked by covalent of the Laboratory of Biochemistry. The film includes Interviews with several cross-links, forms the fibrous structures His laboratory became a major training clinical scientists engaged in genital her­ that he has referred to as the "biological center for postdoctoral fellows In connec­ pes research and treatment. Interspersed rope." tive tissue research and these scientists throughout the interviews are short scenes He and his coworkers were the first to are currently researchers at many institu­ of laboratory work, diagrams, and clinical show that lysines in collagen were enzy­ tions in the U.S. and abroad. slides of herpes lesions. matically oxidized to aldehyde groups Dr. Piez received the HEW Superior Serv­ The Occupational Medical Service, Divi­ which condense to form the cross-links. ice Award in 1966, the T. Ducket Jones sion of Safety, has scheduled showings of The cross-linking enzyme was first isolated Memorial Award in 1970, and presented the film to NIH employees as part of its and described in his laboratory. the G. Burroughs Mider Lecture in 1975. regular education series. Knowledgeable Later work led to the discovery that tis­ He has served on the editorial board for NIH staff will be available to answer ques­ sues such as cartilage, skin and blood the Journal of Biological Chemistry, as a tions. The film will be shown at 11:30 a.m. vessels contain different collagens, each member of many scientific committees, and 12:15 p.m. on the following dates: arising from distinct genes and having dis­ cochairman of numerous conferences and Monday, May 10 Bldg.1 Wilson Hall tinct functions. workshops, and as an officer and member Tuesday, May 11 Bldg, 10 Masur Auditodum Several such collagens are now known, of the board of directors for the Founda­ Thursday, May 13 wes1wood Bldg. Conf. Rm. D Tuesday, May 18 Federal Bldg. Rm. 8-119 and alterations in these collagens are tion for Advanced Education. He was pres­ Wednesday, May 12 Poolesv1\le thought to underlie several heritable dis­ ident of that organization from 1974 to Animal Ctr., 2p,m, orders of connective tissues. 1976 . □ Wednesday. May 19 NLM, Bldg. 38A Lister Hill Lisler Hill Ct1. Auditorium New Brain Tumor Pamphlet Discusses Treatment Aims The key to adequate control and preven­ tion of genital herpes is awareness by the sexually active individual of the infection's An individual's chance of developing a numbness in the arms or legs, and sei­ primary malignant brain tumor is 1 in zures. symptoms, contagious nature and lasting 22,000. There are 11 ,000 brain tumors an­ The new pamphlet discusses these effects. The OMS and NIAID staff believe that Jennifer will help more people be­ nually in the United States, with both chil­ signs, tumor diagnosis, and the different come aware of genital herpes. □ dren and adults susceptible to developing kinds of tumors that occur. Treatment al­ the growths. ternatives such as surgery, radiation and Brain tumors in children are most com­ chemotherapy are described, as are new NAS Public Hearing To Be Held mon at ages 6 to 9 while adult brain tu­ surgical techniques, including the use of On Research Personnel Needs mors usually strike between the ages of 40 high frequency sound waves and laser and 60. The reason why primary brain tu­ beams to destroy the tumors. The Committee on National Needs for mors occur is still a mystery. New methods of treatment for brain tu­ Biomedical and Behavioral Research Per­ Not all tumors are malignant however, mors are currently under study at N INCDS. sonnel of the National Research Council and surgery can remove some tumors In one process called " immune stimula­ will hold its fourth public hearing in Wash­ completely, leaving no neurological dam­ tion," the patient's tumor cells are grown ington, D.C., on June 2 at the National age. According to a new NINCDS publica­ in tissue culture and irradiated to prevent Academy of Sciences. tion, Brain Tumors: Hope Through Re­ reproduction. The cells are then injected The purpose of the hearing is to receive search, a combination of improved surgi­ back into the patient as a means of pro­ comments on the committee's 1981 report, cal techniques, better drugs and radiother­ ducing antibodies. Personnel Needs and Training for Biomedi­ apy can mean longer survival times and Other studies of brain tumor treatment cal and Behavioral Research, and to re­ richer lives for brain tumor patients. currently conducted at NINCDS and else­ ceive suggestions for the committee's fu­ Although the symptoms of a brain tumor where are outlined in the pamphlet. ture work. Persons wishing to testify are vary according to its type and location, Single copies of Brain Tumors: Hope requested to submit written statements by there are certain signs that specialists Through Research can be obtained from May 14. Address to NAS, 2101 Constitution look for: progressive unrelenting symp­ the Office of Scientific and Health Re­ Ave., Washington, D.C. 20418. toms including headache, visual com­ ports, NINCDS, Bldg. 31, Rm. 8A- 06, Comments from the floor are also wel­ plaints, motor signs such as weakness or Bethesda, Md. 20205; (301) 496-5751. □ come. Single copies of the report are avail­ able from the committee. For further infor­ mation, contact Allen Singer, 334-3186. □

April 27, 1982 The NIH Record Page9 Dr. Joseph Tully To Win Two Mycoplasma Awards Genetic Mechanism for Cancer Formation Described Dr. Joseph G. Tully, National Institute of Allergy and Infectious Diseases, will re­ The first molecular evidence for a muta­ ceive two awards this year for his research tion- a gene structure change- in human on mycoplasmas-a group of filterable, cells turned cancerous by a chemical has wall-free microbes that produce disease in been provided by National Cancer Institute humans, animals, plants, and insects. scientists. Dr. Tully, chief, mycoplasma section, In t he past, there have been many re­ Laboratory of Molecular Microbiology, re­ ports of alterations in the products of ceived the J. Roger Porter Award of the genes, such as proteins, in chemically in­ U.S. Federation for Culture Collection dur­ duced cancer cells. These protein modifi­ ing the recent meeting of the American So­ cations have been associated with ciety for Mlcroblology. Next September, he changes in cell appearance, but these will receive the Klieneberger-Nobel Award changes have never been direct ly traced to of the International Organization for Myco­ alterations in the gene itself. plasmology. Until now, evidence for genetic altera­ He is the first recipient of the USFCC tions causing changes in cancer cells has award for "his outstanding research on the been indirect. Data from model systems taxonomy of mycoplasmas and contribu­ such as the Ames test have shown muta• tions to the characterization and preserva­ tions in the cells of bacteria after expo­ tion of this special category of microorga­ sure to a cancer-causing chemical. nisms." Dr. Tully is currently conducting research on mycoplasmas at the Frederick Cancer Research Evidence of these mutations has been The federation intends to give this seen as cancer-like changes, not in bac· award of $1 ,000 and a certificate annually Facility in the NIAID Laboratory of Molecular Microbiology. teria, but instead in an imals or mammalian to microbiologists contributing signif i­ cells grown in a laboratory. cantly to USFCC objectives. Using a newly developed culture me­ In order to establish a direct, causal The IOM Award is named for Dr. Emmy dium designed to grow spiroplasmas, Dr. relationship between mutation and cancer Klieneberger-Nobel, a pioneer in myco­ Tully and his colleagues have been able to formation, it is necessary to demonstrate plasma research. It is also given in recog­ isolate two strains of a new mycoplasma that some agent can cause genetic as well nition of outstanding research in myco­ from urethral specimens of patients with as cancer-like changes within the same plasmology. nongonococcal urethritis. They hope to type of cell. Dr. Tully's contributions to the f ield are show the role of these strains in human Dr. Takeo Kakunaga and coworkers have numerous. In 1972, while collaborating disease. done that by demonstrating a gene muta­ with French workers, he identified and Dr. Tully chaired the organizing commit­ tion associated with cancer formation or carefully defined the first cultivated mem­ tee of the International Organization for carcinogenesis in normal human fibro­ ber of a new group of mycoplasmas, the Mycoplasmology and served as IOM chair­ blasts, called KO cells, derived from con­ spiroplasmas man from 1976 to 1978. In 1980 he received nective tissue turned cancerous by a Since then, he has isolated and identi­ an honorary doctoral degree from the Uni­ chemical. fied other members of the group: the first versity of Borde<1ux II , France. This work was reported by Drs. Hiroshi spiroplasma found to produce an experi­ He joined NIAID in 1962 as a research Hamada, John Leavitt, and Takeo Ka­ mental neurologic and ocular disease in microbiologist in the Laboratory of Bacte­ kunaga in the June 1981 Proceedings of vertebrates, and a number of tick-borne rial Diseases, and became chief of the my­ the National Academy of Sciences, vol. 78, spi roplasmas. coplasma section, Laboratory of Microbiol­ no. 6, pages 3634-3638. □ ogy in 1968 . □ Neuropharmacology Is Subject Nurse Mary D. Thompson Ends 28-Year CC Career Of Dr. Potter's Research Dr. Pamela E. Potter, a graduate of Dal­ After 28 years of nursing at the Clinical partment, said, " Mary Thompson has been housie University, Halifax, Nova Scotia, Center, the deputy chief of the CC's Nurs­ an invaluable nursing resource at the CC Canada, began an international research ing Department, Mary D. Thompson, retired for many years. Her presence as a leader fellowship of the Fogarty International on Apr. 3. has been vital in its growth." Center at the National Institute of Mental Ms. Thompson began her career in the Health under the preceptorship of Dr. E. CC as a staff nurse. Later, she was pro­ Costa in February. Her research is on moted to night supervisor and head nurse. neuropharmacology. □ In 1975, she was appointed chief of the Heart and Lung Nursing Service, and as­ Want To Go Horsing Around? sumed the position of deputy chief in 1977. R&W is sponsoring a horseback rid ing One of the highlights of her career was weekend, May 14-16 at Deep Creek Lake a 1972 nursing conference on myasthenia in western Maryland. Cost is $84 per per­ gravis, a disease characterized by muscu­ son, which includes boarding, unlimited lar fatigue and weakness. She served as horseback riding and a hayride. The trip is its coordinator. limited to 20 persons. Commenting on her lengthy service at Reservations can be made at R&W Desk, the CC, Ms. Thompson said, " I would like Bldg. 31, Rm. 1A-18. □ to feel that I have contributed to the pres­ ervation of the caring attitude here. I hope Stop Smoking! that it will never change. Despite the re­ The Employee Assistance Program will search going on, there is tremendous con­ present another Stop Smoking program be­ cern for the patients. The concept of truly ginning May 12 to run six consecutive respecting individuals as human beings is Wednesdays from 12:30 p.m. to 1:30 p.m. outstanding in the CC." Nurse Thompson holds up a farewell gift. She in Bldg. 31, Rm. 828-35. At the farewell party for the retiring dep­ played a key role in the ACRF planning as a For further information, call Morris uty chief, Rena M. Murtha, chief of the de- member of the committee making inspections at other medical centers throughout the country. Schapiro, 496- 441 1. □

Page 10 The NIH Record April 27, 1982 Three CC Nurses Receive Awards for Exemplary Service NIH's Betty Ford Retires; Clinical Center nurses Michelle Maher, and removing the mucus or by going Moves to Hilton Head Dorothy Belling, and June McCalla were through an opening in a connecting piece " There may have been a few headaches recently presented with individual awards in the respirator itself, while maintaining along the way, but it was never boring." from their colleagues in the Nursi ng De­ the patient on the machine. That's how Betty Ford, recently retired partment for special achievements. Using both procedures, each patient secretary to the NIADDK clinical director, was sustained on a 2-hour interval be­ summed up 28 years of government serv­ Nurse of the Year tween suctions performed so a compar­ i,ce at the NIH. " It has been a privilege to Ms. Maher, a nurse specialist in the ison could be done. The study proved that work with such brilliant people," she said. Cancer Nursing Service, was selected although it took longer to suction patients Mrs. Ford came to NIH In 1956 as a part­ Nurse of the Year, an award honoring a while maintaining them on the respirator time medical transcriber in the Clinical professional nurse actively engaged in than it did when they separated from ii, Center. From 1961 to 1967, she worked In nursing at the CC. their blood oxygen levels were signifi­ the National Heart Institute as secretary to The recipient, nominated for this award cantly higher on the respirator. Ors. J. 0. Davis and Jack Orloff. In 1967, by her peers, is recognized for her contri­ Her research entitled The Effect on Ar­ she joined NIADDK as secretary to the bution to the care of patients in a research terial Gases of the Use of a Portex Swivel c hief of the Arthritis and Rheumatism environment. Adaptor to Maintain Respirator Connection Branch, Dr. John Decker. Ms. Maher, who has worked in the CC During Suctioning, is the first published When Dr. Decker was named clinical di­ for 13 years, was selected because of her study on the subject. rector in 1976, she accompanied him to involvement in total parenteral nutrition Distinguished Nurse Award the new post, where she remained to as­ (TPN), a method of providing nutrients to sist the current clinical director, Dr. Phillip patients intravenously through a central The Distinguished Nurse Award was Gord en. venous catheter. presented to Ms. Mccalla, a CC employee She is the nurse specialist on the TPN for over 30 years. The honor is given to Witnessed Research Benefits team, and it is her responsibility to see recognize a professional nurse whose con­ Mrs. Ford said it has been especially that specific nutrients are given properly tribution to nursing goes beyond her reg­ gratifying to witness how research devel­ to patients. ular CC duties and merits commendation. opment has benefitted patients, citing as A c lin ical nurse specialist/practitioner in Nursing Research Award an example the greatly improved prognosis the Pediatric Oncology Section of the for patients with systemic lupus erythema­ Also honored was Ms. Belling, a clinical Cancer Nursing Service, Ms. McCalla re• tosus. nurse who works in the Heart and Lung ceived the award for her contributions to " When I first joined the Arthritis Insti­ Nursing Service. She is the first recipient pediatric nursing at the CC as well as lo­ tute, medical science could do little for of the Nursing Research Award-cited for cally and nationally. I upus patients. Now almost all patients her contributions to the practice of bed• Her responsibilities include the provi• with lupus respond to treatment and leave side nursing in the CC through nursing sion of health care and preventive serv­ t he Clinical Center with hope for the fu­ research. ices. This covers patient and family coun­ ture." Ms. Bell ing, a CC employee for 21 years, seling in child growth and development, Before joining NIH, Mrs. Ford worked on conducted a 9-month study on two tech­ nutrition, common illness, accidents and Capitol Hill for several years. niques of suctioning mucus from patients child rearing. She and her husband, Pat, a retired CPA, while on respirators. This was done by All of the awards were presented by have moved to Hilton Head Island, S.C. □ separating the patient from the respirator, Mary Thompson, deputy chief, and Rena inserting a plastic tube into the trachea, Murtha, chief, CC Nursing Department. LJ

Fair To Be Held by NIAID Visiting Scientist The NIAID women's subcommittee is co­ Program Participants ordinating the Second Annual Multi-Cul­ Sponsored by Fogarty International Center tural Awareness Fair to be held July 14 (Bastille Day) from 5 to 8 p.m. in the Bldg. 3122 Dr. Arun Kumar Attri, India, Laboratory of 31 cafeteria. The entire NIH community is Biochemical Pharmacology. Sponsor: Dr. Allen Minton, NIADDK, Bg. 4, Rm. 8127. invited to participate with displays, acts, 3122 Dr. Norio Sasaki, Japan, Laboratory of Bio· contributions of ethnic foods, or assist­ chemical Pharmacology. Sponsor: Dr. Matthew ance in planning and attendance. Rechler, NIADOK, Bg. 4, Rm . B114. "The original fair in August 1981 was in­ 3123 Dr. Fritz Buchthal, Denmark, Medical Neu• tended to give students a glimpse of the rology Branch. Sponsor: Dr. Thomas N. Chase, ethnic diversity of the NIH community," El· NINCDS, Bg. 10, Rm . 4N245. nora Jackson, women's subcommittee 3125 Dr. Atul Sahai, India, Laboratory of Patho• manager, explained. It featured crafts, physiology. Sponsor: Dr. David Salomon, NCI, arts, dance, drama, songs and foods repre­ Bg. 10, Rm. 5B55. senting the diverse ethnic heritages of NIH 3/29 Dr. Ken-ichi Tominga, Japan, Laboratory of employees and others who serve NIH. Socio•environmental Studies. Sponsor: Or. Carmi Schooler, NIMH, Bg. 31, Rm. 4C21. A series of planning meetings is under David L. Mineo, a recent graduate of the NIH 3/30 Dr. Wei•Chao Ni, Taiwan, Laboratory of way. The coordinators encourage anyone S tride Program, was selected by American Uni­ Biochemistry. Sponsor: Dr. Charles Huang, who wishes to help with any aspect of versity to receive the Financial Executive lnsti- NHLBI, Bg. 3, Rm. 218 staging the event to attend these brown­ 1ute's award in recognition of his outstanding academic achievement in finance. Mr. Mineo 3/31 Dr. Krzysztof Wlodarski, Poland, Laboratory bag sessions. They are scheduled for 11 :30 of Biological Structure. Sponsor: Or. A. H. Reddi, ,graduated magna cum laude in 1981 and is a a.m., Apr. 22 and May 20 in Rm. 7A-24; member of the Phi Kappa Phi honor society. He NIDA, Bg. 30, Rm. 207. June 17 and June 24 in Rm. 2A-52; all in 4/1 Dr. Christian Krarup, Denmark, Medical received his job training In the Grants Manage­ Neurology Branch. Sponsor: Dr. Thomas N. Bldg. 31, and for July 1 and 8, location to ment Office of the National Institute on Aging. Chase, NINCDS, Bg. 10, Rm. 5N222. be announced. His future career Interests are to continue his 4/1 Dr. Aldan McEldulf, United Kingdom, In addition, persons interested in provid­ work with the NIA while pursuing an MBA in Diabetes Branch. Sponsor: Dr. Jesse Roth, ing entertainment, demonstrations, dis­ either finance or business-government relations. NIADDK, Bg. 10, Rm . 8S243. plays or foods may do so by calling Mrs. Jackson at 496-10 1 2. □

April 27, 1982 The NIH Record Page11 Ors. Davies and Potter Will Present Dr. Michael Cole Receives Annual R. E. Dyer Lecture, May 12 1982 Oral Science Award An International Association for Dental Dr. David Davies, chief, molecular struc• been completely visualized by X-ray dif• Research panel selected Dr. Michael F. ture section, Laboratory of Molecular Bi· fraction. Cole, a research investigator with the Na• ology, National Institute of Arthritis, Dia­ He has been a member of the National tlonal Caries Program, National Institute of betes, and Digestive and Kidney Diseases, Academy of Sciences in biochemistry Dental Research, to receive the 1982 Oral and Dr. Michael Potter, chief, immuno­ since 1978. Science Research Award. chemistry section, Laboratory of Cell Bi­ Dr. Potter will discuss mechanisms of The presentation took place Mar. 18 dur­ ology, National Cancer Institute, will pre­ diversity in a series of closely related anti­ ing the association's 60th general session sent the R.E. Dyer Lecture on Wednesday, body molecules, in particular the galac­ held in New Orleans. The award, spon­ May 12, at 8:15 p.m. in the Clinical Center tan-bindlng myeloma proteins, which are a sored by Procter and Gamble Company, is Masur Auditorium. family of mouse antibodies that bind to presented annually to promising young in­ The two-part lecture is entitled The the same antigen. vestigators under age 35 who have made Three-Dimensional Structure of the Anti­ In the course of his research career, he outstanding contributions in the field of body Molecule: Specificity and Diversity. has concentrated on the study of the dental research. Dr. Davies will focus on the three• plasmacytomas in mice, tumors that pro­ dimensional structure of the antigen­ duce antibody molecules. Over a period of binding fragments of mouse myeloma pro­ 28 years, he created a system of plasma teins with known binding specificities. cell tumors that have been used for most Using X-ray crystallography, he analyzes of the fundamental studies in immuno­ X-ray diffraction patterns of the specimen globulins, making possible the develop­ molecule. ment of hybrldoma technology. Dr. Davies has been Involved in protein His work has included the pathogenesis structure determinations since the earliest of plasma cell tumors, and the genetics, days of this research. He collaborated on structure, and diversity of antibody mole­ the high resolution structure of myoglobin, cules. He is currently studying the anti­ the first protein to have its three-di­ gen-binding properties of myeloma pro­ mensional structure described. teins, which may have clinical application He has also worked on the structure and In the rapidly growing field of monoclonal physical chemistry of many synthetic antibody research. polynucleotides, such as Poly (I & C) which Dr. Potter received the U.S. Public became model systems for studying nu­ Health Service Meritorious Service Award Dr. Cole began his research career at the Royal cleic acids. His section has also deter­ in 1969 and the Distinguished Service College of Surgeons in England, where he mined the structure of two proteolytic en• Medal in 1981. During the past year he was studied the ettect of cariostatic agents on the zymes, gamma-chymotrypsin and an acid elected to the National Academy of Sci­ chemical and microbial composition of dental protease from R. chinesis. ences in microbiology and immunology. plaque in monkeys. The Dyer Lecture was established in Dr. Davies' current interest in immuno­ Much of Dr. Cole's research has focused 1950 to honor former NIH Director Dr. globulins was sparked by Dr. William Terry on the role of immunoglobulins in plaque Rolla E. Dyer. The lectureship is awarded of NCI, who introduced him to the field of and saliva, and their role in dental caries. annually to scientists who have made an myeloma proteins and their potential for Since joining NCP, he has extensively outstanding contribution to knowledge in a crystallography. This original protein is studied host defense factors in plaque field of medical science.n still the only antibody molecule that has fluid obtained from chi ldren and adults to determine how the host regulates the pathogenic potential of plaque microor­ Jack Turlik Retires as NHLBI Contracts Chief ganisms. He is currently studying the ability of Jack Turlik, chief, contracts operations nlzed throughout NIH. During his NHLBI various routes and regimens of immuniza­ tenure, he was active In personnel man­ branch, Division of Extramural Affairs1 tion to induce secretory lgA antibody NHLBI, retired recently after 32 years of agement and contracting. against not only Streptococcus mutans, government service. but also other mucosal pathogens, such His Federal career Included service in as Escherichia coli. the U.S. Navy during World War II and 11 Dr. Cole received his dental degree and years with the U.S. Treasury Department. Ph.D. degree In microbiology from the Uni­ In 1961, he entered NIH as an assistant versity of London. He also has a master's employment officer. degree in immunology from Brunel Univer­ The following year he joined the Na­ sity, London. tional Heart Institute as administrative Dr. Cole was the first to use plaque fluid officer fonhe Office of the Director, a to study bacterial metabolism in plaque. position he held until 1965. At that time, He has been actively involved in develop­ he became program contracts officer of ing a vaccine against dental caries, em­ the Artificial Heart Program, and was in­ ploying both primate/rodent models and strumental in the development of this mul· human volunteers. tidisclpllned contracts program. He and a colleague at the Institute of He assumed the duties of deputy chief, Dental Research, University of Alabama in Contracts Operations Branch, in March Birmingham, are credited with first de­ 1973. Mr. Turlik also assisted in the devel­ scribing the direct bactericidal action of opment and implementation of the the innate mucosa! immune factor lacto­ NHLBl's contracting policies and proce­ ferrin, and demonstrated the abi lily of se­ dures. In July 1981, he became chief of the cretory lgM antibody to compensate for branch. In addition to his meaningful contribution to the the absence of SlgA antibody in the saliva Mr. Turlik's professional abilities and application of NIH procurement regulations and of some selectively-lgA-deficient sub· valuable contributions were widely recog- personnel management over the years, Mr. Turlik jects.D was noted tor his sense of humor and pleasing personality. US GOVERNMENT PRINTING OFFICE 1982-341•t34/16

Page 12 The NIH Record April 27, 1982