May 30. 1989

Vol. XU No. 11 U.S. Departmenr of Health and H uman Services

National Institutes of Health

NIH's 'Legislative Father' Director Reflects on 7½ Years at NIH Bldg. 31 Renamed; ll)' Rich McManus Honors Claude Pepper Par/ one ofa two-part ,eries Under rainy skies char were brighcened Sometime chis sumrner, NIH direccor Dr. purchasing power. During his 7 'Ii-year rerm, considerably by the music of rhe Marine Band, ]tunes B. Wyngaarden will relinquish whar rhc institutes have realized a 35-40 percent Bldg. 31 was recently renamed in honor of many consider the most powerful post in gain in purchasing power. Rep. Claude Denson Pepper (D.-Fla.). The American medicine. He will leave behind a Other statistics salure his dedication to legislative sponsor of all bur one NIH legacy t hat is ac once easily computed and stabilizing and promoting rhc advance of insciruce, Pepper was hailed as NIH's hard ro fathom. biomedical research. Boch the number and "legislative father." Easy co grasp are rhe achievements chat d uration of investigator-initiated research proj­ Hospitalized in recent weeks for a stomach numbers can capture. Arriving as dircccor on ect grams are up, a robust conscrucrion ailment, Pepper, 88, was unahle to attend the Feb. I, I 982 (though nor formally inducted program is under way on campus, vigorous ceremony rededicaring rhe 28-year-old office until Apr. 30), he gave himself the goal of and talented staff occupy virtually all top building. Speaking in his place was Sen. doubling the NIH bL1dget during his term. management positions, a full-scale assault has Edward Kennedy (D.- Mass,), who described The 1990 budget assures fulfillment of that been mounted on the AIDS epidemic and the himself as a follower in Pepper's foorsreps. ambition. most ambitious biomedical research project " Lr is a very special honor for me co be here In rhe 4 years preceding his arrival on ever attempted-the human genome on behalf of Claude Pepper," he said. "One of campus, NIH suffered a l4 pcrcem loss in (See DIRECTOR, Page JO) Claude's honors is chat he's the only congress­ man we call senaror (Pepper was a senator from Florida for 14 years; his long term in Congress followed a 12-year sriot as a lawyer in private practice). "But most Americans call him Mr. Senior Cirizen , for his extraordinary conrriburions to che elderly," Kennedy continued. "He is a cirelcss defender of Medicare and Social Securit)', and those programs are strong today (See PEPPER, Page 2 )

Pallor Parlors May Be In Consensus Panel Says 'Ban the Tan,' Declares Tanning Unhealthy NIH director Dr. James B. \'(/p1[!,aarden (I) conferJ with Sen . Edward Kennedy outside the newly ,·ededi­ ,-ated Claude Demon Peppt1· Building. Kennedy praised \Ylyngaarden. who recently a11r101mced his llr Patricia Blessing mig11atio11. for "an 011tJt,111di11g job" ar direrto1·.

Exposure to ulrraviokt radiation, whether from sunlight or canning_ parlors, damages the Still the Second Best Thing About Payday skin and is a major faccor responsible for the increasing number of skin cancers, according NIH Record Celebrates Its 40th Anniversary co a panel of experts ac a recent NIH con­ On May 20, l949, the first issue of The malaria in Ease and West Africa could share sensus development conference. N IH Rttord made its debut on the N IH equal billing with opening day of rhe NIH To reduce che risks of sun-induced damage campus. There was no front-page fanfare softball league. to rhe skin, the 14-member panel recom­ announcing its arrival on the scene. It just "There weren't as many donors running mended less exposure to midday sun, -better appeared one day, looking like it had bem regularion of and education on the hazards of around the new diamond near the main published for years. tanning parlors, and daily use of sunscreens, entrance as used to be seen cavorting on the Back then, N IH and its parent a,iscncy PHS especially in Sun Belt areas. Members of the old field (oow oblircrared by construction of were part of the Federal Security Agency, a panel also concluded that, at chis time, there the Clinical Cearcr), .. wrote the unabashedly is insufficient evidence co recommend the use face duly noted in the masrhead. The firsc nostalgic reporter, "but the season is young issuc·s banner headline read: "NIH To Help of cosmetic therapies such as Retin-A and sim­ yet. Ors. Orman Topping, F.A. Arnold, J .J. ilar compounds co diminish or reverse wrinkles Combat Disease in Africa." Griffitts, and ocher medical ballhawks will be caused by the sun. That those were more casual days is our chere any day now." "Tanning is visible evidence of injury co the re0ecced in the issue's second biggest story, Doctors cavorting' Medical ball hawks' skin," said Dr. David R. Bickers, professor headlined "Softball Again! But Where are the Surely ir was another age being described, one and chairman of the department of dermatol­ Docs?" char may even have been kinder and gentler. ogy at Case Wesrern Reserve University, who forty years ago, NIH was a comfy enough The early issues, their newsprint now yel­ outpost for ics I , 500 employees chat a scory lowed. were an informal mix of science news, (See SUNTAN, Page 4 ) about the control of rrypanosomiasis and (See RECORD, Page BJ page 2 The Record May 30, 1989

PEPPER Seven years lacer he chaired a subcommittee on wartime health and education, concluding, (Continued from Page JJ "'The volume of research which is carried out because of strong champions like Claude in the medical field should, in my opinion, Pepper." not be limited by lack of money." NIH director Dr. James B. Wyngaarden In 1948, Pepper sponsored a bill establish­ sketched a biographical profile of Pepper, ing the National Heart Institute and changing characterizing him as '"an eyewicm:ss co the the name of what was rhen the National 20th century. Institute of Health co its present plural form. '"Most of us know Sen. Pepper for his '" In shore, he christened us and went on co ardent advocacy for the cause of the elderly sponsor legislation chat created the first five of and his recenr efforts in creating the deafness the then six NIH institutes," Wyngaarden institute (NIDCD),'" said Wyngaarden. "But said. he has accomplished much, much more for Pepper believed chat NIH should have NIH and the nation." authority co grant research money co investiga­ Born on a farm near Dudleyville, Ala., Pep­ cors outside che inscitures and was instrumen­ per grew up in rural Alabama and Texas. By tal, along with philanthropist Mary Lasker, m age l 7 he was teaching high school. In I 92 l geccing larger budgets for NIH. he completed an undergraduate degree at the '"The total N lH budget in I938 was enjoyed working with him, and we wish h im $464,000 and we had 912 employees," we II as he moves on. '" W)•ngaarden recounted. "'By 1950, the year A videotape crew commined the entire cer­ Sen. Pepper lcfr che Senate, che NIH budget cmon)' ro film and captured several individual was $59 million with $43 million in grams, tributes co Pepper given by friends and associ­ and we had 2,888 employees. Much of chis ates. The cape will be presented co Pepper, exponential growth was due co Sen. Pepper's currently hospitalized in Washington. and Mary Lasker's combined efforts.'" Guests at the ceremony included Dr. James Last fall, Pepper enacted legislation estab­ Ford, chaplain of che House of Representa­ lishing a National Cencer for Biotechnology tives, who gave the invocation, former Rep. information ac the National Library of Medi­ Paul Rogers, Rep. Marrin Fcosc of Texas, and cine; it will disseminate information gained m many institute officials.- Rich McManus 0 the human genome research program. "This was a visionary bill," said Wyn­ gaarden, '"one that will impact medicine far Ken11edy ( I) a11d Wy11fl,aarde11 tllf!, 011 a rope that beyond the 20th century." unveils the 11eu1 name on Bldg . 3 I. Due 10 ii/nm. Concluding his remarks, Wyngaarden said, Rep. Claude Pepper was unable tn a/tend the cere­ '"ln 193 7 (Pepper) started the engine of che mony honorin?, him. NIH modern NlH. ln 1948 he ser the vehicle in The Record Published biweekly at Bethesda, Md.. by the Editorial motion, so that even in 1961 (the year Bldg . Operations Branch, Division of Public Information, for ,he University of Alabama. Following a brief term 3 l was first dedicated), Building 3 l was information of employees of the National Institutes of in che Army, he attended Harvard Law School already rhe Pepper Building. The Claude Health, Deparrmem of Health and Human Services, and on the post-World War I equivalent of the Denson Pepper Building scands as a lasting circulated to nonemployees by subscription only rhrough the Government Priming Office. The concem is reprintable G.l. bill, and obtained his degree in 1924. monumenr co his vision and dedication co bio­ wirhour permission. Piccures ma>' be avallablt on request. Pepper caught law at the University of medical research and chc nation's health." " For half a century," said Kennedy, "(Pep­ Use of funds for printing rhis periodical has been approved Arkansas for a year then moved co Florida, by the director of the Ofllce of Management and Budget per) has been a leading force in making NIH where he began a law practice and commenced rhrough Seprember 30, 1989. a political career chat still continues. what it is today, a worldwide symbol of excel­ lence in medical and biomedical research. His NJ H Record Office s,~ff Correspondents: Emphasis on health and human welfare CC, Ellyn Pollack name on chis building is a fitting tribute co Bldg. 31, Room 2B-03 issues marked his service in the Florida state Phone 496-2 125 DCRT, Chrisnne Pennella legislature, co which he was elected in 1929. his commitment, and a reminder co all who DRG, Sue Meadows '" H is first bill exempted the elderly from come here chat we must work even harder Editor O RR, M ichael Fluharry together co maintain and strengthen chat com­ R,chard McManu, D RS, _I 1m Doherty having co pay for fishing licenses, setting a FfC, Elizabeth Gillette Assistant Editor theme for a lifetime," Wyngaardcn recalled. mitment for rhe future . .. This building is NCJ , Parricia A. Nc:wman Anne Barber '"In 1931 he was defeated for reelection che nerve center of NIH, and in naming it for NEI, Claudia Feldman because he refused co support a bill censuring him, you are honoring che best in Cong ress, NHLBI , Blair Gately Mrs. Herbert Hoover for inviting the wife of a chc best in NIH, and the best in our Carta Garnccc NI A, Margo Warren NIAID, James Hadley newly elecred black congressman to tea at the coumry. '" Editorial Assistant N JAMS, Barbara Weldo11 White House. I chink ic is most appropriate Their speeches over, W yngaarden and Ken­ Marilyn Bt:rirnrn N IDDK, Eileen C-Orrigan that che Pepper Building houses the NIH nedy rugged on a rope chat unveiled the new N ICHD, Carol Florance Equal Employment Opportunity Office.'" name on che A wing. Earlier in cbe ceremony, 'fhe NIH Rr4rd reserves the nghc NIDR , .Mary Daum co make corrcct1ons, ch.-mges, or NJEHS, Hugh J. Lee Kennedy cold the director, who is leaving Elected in I 93 7 co the U.S. Sen ace, Pepper. ddc:dons rn submirrcd copy in NIGMS, Wanda Warddtll as one of his first official acts, sponsored legis­ NIH chis summer, that he has "done an our­ conform1ry w1ch 1ht p0licies of the NCNR, Gerry Pollen lation establishing the National Cancer standing job ac the NIH. All of us on Capitol pape, and HHS. NINOS, Carol Rowan lnsci cute. H ill arc proud of h is achievements. W e've NLM, Ro1:er L. G ilke,on page , The Record May .lO, 1989

NIH Conducts First Approved Gene Transfer in Humans

Scicnrisrs ar NIH have, for rhe firsr rime in was scrut inized for 7 months by an equal gene-altered TJL co rhe patient, the sciencists an approved study, rransferred cells containing number of review committees. In chis trial, rest the solution containing rhe TIL to verify foreign genes into a human. Rosenberg, Blaese and Anderson are giving chat it is virus-free. Ar approximately L0:47 a . m. on May 22, the gene-altered TIL ro up co lO patients with In an effort co minimize risk co patients, Drs. Steven A. Rosenberg and R. M ichael advanced melanoma, a cype of skin cancer. the researchers have taken extensive precau­ Blaese of the National Cancer Jnstirucc, and The patients, whose life- expectancy is approx­ tions, including first conducting careful W. French Anderson of che National H ean, imately 90 days, have g iven wriccen consent laboratory and animal experiments. Patients Lung, and Blood lnsciture infused che first indicating that rhey have been fully informed participating in the gene transfer srndy may cancer patient with special cancer-fighting and are aware of che risks associated wirh the benefit from TIL therapy itself, which is part cells that had been altered by inserrion of a trial. of the scud)'. T he inserted gene will have no gene so rhar they can be cracked in the Lase year Rosenberg and ochers reported impacr on the therapy itself, however; ocher patient's body. By doing this, rhe researchers char T!L therapy produced remissions in more paciencs may receive benefit if the gene trans­ aim to increase their understanding of TIL than half (55 percent) of 20 patients wich fer experiment helps researchers to improve therapy. advanced melanoma. T o find our why some Tll therapy. In the future, the scienrists hope Tumor-infiltrating lymphocytes (TJL) are patients respond while ochers do not, the co enhance che effectiveness of TIL by insert­ removed from che patient's rumor and researchers arc using the rransferred gene as a ing into chem genes wirh therapeutic increased in number by bathing chem in the marker co identify chose TIL char have reached pocenrial. laborarory wirh the growth factor inter­ the patients' cancer cells. "Ultimacely, this new technique could open leukin-2 (IL- 2). When transferred, along with The researchers are using an altered mouse che door co srudics char will use gene insertion more !L- 2, co rhe patient, TIL home in on virus co carry the gene into the cell. To avoid to produce therapeutic results in a wide range the tumor from which they were derived. any potential harm, the virus has been deliber­ of diseases,·· said Dr. James Wyngaarden, Prior co approval, the landmark gene study ately crippled so that it cannot reproduce in NIH direccor.-Elaine Blume D rhe patient. In addition, before returning rhe

Greenspan Team To Deliver Kreshover Lecture, NIDR's Seventh

Oral complications of AIDS will be the lighcs rhe work of rhe Greenspans as well as topic discussed ac the L989 NIDR Seymour many ocher dental scientists on rhe forefront of J. Kreshover Lecture when Drs. Deborah and dental research. J ohn Greenspan, a husband and wife research The NIDR Kreshover Lecture series was ream from the University of California ar San scarred in 1983 co recognize outstanding Francisco (UCSF), present their lecture on accomplishments in basic and clinical research "Pathogens, Probes and Perceptions- The and co honor distinguished sciencisrs who have Story of Multidisciplinary Oral AJDS made imporcant contribucions in areas of Research." The lecture will be given Tuesday, research direccly related co che inrerests of June l3, at 2:30 p.rn., in Lipsett Amphi­ N IDR. The series was named in honor of Or. theater, Bldg. 10. Seymour J. Kreshover, who served as NIDR J ohn Greenspan heads the UCSF Oral AIDS direcror from 1966 until his retirement from Center, which focuses on research, ueacmenr the PHS Commissioned Corps in 1975. 0 of the oral manifestations of AIDS and AIDS education. Deborah Greenspan d irects the clinical unit of the center. Computers in Nursing Explored The Greenspans have made major contribu­ tions boch to oral and general AIDS research. The sixch National Conference on Computer They were among che first researchers to Technology and Nursing will be held Friday, describe AIDS symptoms in the mourh and June 23 in Masur Auditorium, Bldg. 10. discovered the unusual oral lesion known as Sponsored as a public service by rhe Clinical hairy leukoplakia, now recognized as an early Center's nursing department, the conference sign of rhe development of AIDS. The Green­ begins at 8 a. m. and ends at 4 p. m. Registra­ spans established rhe link between the lesion tion deadline is June 2. and the Epstein Barr virus. In addition, they The conference will assess rhe impact of have developed a treacmenr for hairy leuk­ technology and information system develop­ oplakia and ocher oral problems associated ment on nursing and health care delivery. with AIDS. Their extensive research encom­ Sessions will highlight previous effects of tech­ passes chc epidemiology of oral AIDS, oral nological innovations and will explore future lesions associated wirh the disease and inves­ possibilities and priorities for development, tigations involving rhe AIDS primate model. research and applicacion. On the occasion of the Kreshover Lecture, a For information and registration, call new documenrary film for public television Charmaine Cummings, director of nursing also will be previewed. Called "The Changing education, 496-1330. 0 Faces of Dentis cry," the documentary high- Dr. John Greenspan pa,;e '1 The Record May \0, 1989

SUNTAN The use of drugs to creac sun-damaged skin percent increase in UVB levels at the Earth's has become more popular because of recent surface. Studies presented at the conference

PHS Honors NIH Employees for Outstanding Achievements

NIH sraff members were recognized for Dr. Thomas S. Reese PHS Special Recognition Award for their outstanding achievements and contribu­ Chief, l.aboracory of Neurobiology Produccivicy tions at the fifteenth Annual Public Health Narional lnsciruce of Neurological D isorders Service Honor Awards Ceremony held May 24 and Stroke Dr. David W. Alling in Masur Auditorium. Dr. James 0 . Mason, "Or. Thomas S. Reese led the reseanh gro11p Special Assiscanr for Biometry, Intramural DHHS assistant secretary for heal th, assisted that rli1covered the molemlttr basis of ttxonal tram­ Research Program by D r. C. Everett Koop, U.S. surgeon gen­ port and a new type of protein. kinesin, which National Inscicuce of Allergy and Infecrious eral, and Dr. James B. Wyngaarden, N IH xenerates movements in all cells. " Diseases d irecror, presented rhe awards. "For many years o/pio11eering and 1miq11e con­ Dr. Philip E. Schambra tributions in Jtatistics and controlled clinical t,·ials, PHS Superior Service Award D irector, Fogarcy Internacional Center and notable contributions to ,·march at NIH." "for exceptional pe1for111,111ce in advancing the Stephen A. Ficca interest of the Public Health Service and the United Marianne S. Wagner Executive Officer States as Science Attache in the U.S. limbassy i11 Chief, Personnel Management Branch National Heare , Lung, and Blood Institute New Delhi." Nacional Cancer lnsticute "Pot' recognition of 011tstandi11g contrib111ions to ··For providing substa11five leadership in the the imprrwed management of the P//blic Health PHS Special Recognition Award developmellt and implementation ofa productive and Service programs at the National Instittttes of responsive personnel management program by imp,·ov­ Health .., l3enjamin E. Fulron ing organizational struclt;res and work processeJ. " Deputy Executive Officer Dr. Ronald N. Germain National Inscirnte of Child Heal ch and ASH's Special Cicacion Medical Officer Human Development National lnstirnce of Allergy and Jnfeccious "For oll/s/a11di11g leadership and managerial Doris J. Kitzmiller Diseases skills in s11pport of NJCHD program activities." Secretary, Office of the D irector "For exceptional contributions to the 11ndersta11d­ D ivision of Blood Diseases and Resources ing of the molemlar hmis of T cell antigen Dr. Gregory A. McDonald Nacional Heare , Lung, and Blood Insticute recognition through insightful studies of class l/ Senior Scaff Fellow "For consistent high q11ality pe,-for111ance and 111ajo,- histocrm,patibi!ity molecules and of T cell National lnscicute of Allergy and Infectious dedication to excellence. · · receptor polypeptides. " Diseases "For basic research in the development of a PHS Equal Opponuniry Achievemenc Award Dr. William H. Goldwater reco111bi11a11/ vaccine to prevent Rocky Mo11ntain Health Scientist Administrator spoued fever. •· J. Harrison Ager Office of the Director Equal Employment Opportunity Ma nager ;.For sNpe,-io,· colllt'ibutiom in tra115/ati11g mrrent Dr. Clarice D . Reid National Inscitute of Diabetes and D igestive and emerging Fede,-al laws rmd regulations pertain­ Acting Direccor, Division of Blood Diseases and Kidney Diseases ing to biomedical resea,·ch and training imo 11sefid and Resources "'For providing a significant leadmhip role in NIH policies and procedures.·· Nacional Heare, Lung, and Blood !nscicute the area of equal opportunity at NIH, the local ··Fo,· exreptional service in providing 011tstandi11g com11umity and in academic imtit11tiom." John P. Hartinger scientific and administrative leadership i11 the Chief, Financial Management Branch development and management of blood-related pro­ Distinguished Service Medal National Cancer Inscicute gramJ 11ital to the health of the nation.,. ''For excellent leadership in the ma1u1gement of Dr. Scuarc A. Aaronson the National Cancer lnstit11te's budget. innovative Dr. Maryann J. Roper Chief, Laboratory of Cellular and Molecular me of computer terhnology ,md mperb direc1io11 of Acting Deputy Dircccor Biology the Financial Management Brauch." Nacional Cancer lnscicuce National Cancer [nsricure "'In recognition of he,· exemplary leadenhip and ,;For 011tsta11di11g co!ltribmions in the fields of Dr. Yoke Peng Loh dio-ection of the National Cancer Program and retrrwirology , oncogenes and growth factors which Head, Section of Cellular Neurobiology exceptional contrib11tiom to the plan11ing activities have led to the understanding of the molemla,· basis National Instituce of Child H ealth and for the AIDS progrmn. •· of human cancer. ,. Human Development '·for discovery of the 111echaniJ111J by which pro­ Dr. W. Emmett Barkley hormones are processed. leading to major advanm in Director, Division of Engineering Services cell biology and to practical applicatiom in rhe Office of the Director recombinant DNA sy111hesis of hormones.·• ·'for smtained excellence in p,·oviding essential mpport to biomedical research thro1Jgh energetic leadership a11d diligent di>wtion of the NIH Divi­ sions of Safety and Engineering Service.r."

(Continued on Page 6 ) 1"'8• 6 !re Record May 30, 1989

(Continued from Page 5 ) Dr. James C. Hill Dr. Joel Moss Deputy Direcror Chief, Molecular Mechanisms Senion National lnstirnce of Allergy and Infectious National Hearr, Lung, and Blood i nstitute Dr. Alan S. Rabson Diseases "Fa,, st11dies defining 111olec11/ar mecha11is11Lr Direcror, Division of Cancer Biology "In recognitio11 of contin#ed 011tsta11ding contribu­ respomible for regulation of reuptor-mediated Stf!.nal and Diagnosis tiom 10 the directio11 . coordination and 111anage111mt m111sd11ctio11 by g11ani11e m1deotide-bi11di11g(G) pro­ Narional Cancer Institute of NIAID AIDS resectrch activities.·• teim and the effects of bacte1·ial toxins. " "In recognition of exceptional co11trib11tions to American science as both a scientist and "dmi11istr{l­ Dr. Peter M. Howley Dr. Pierre f . Renault t01· with the National Cancer Program ... Chief, Laboratory of Tumor Virus Biology Deputy Direccor National Cancer Institute National lnscicuce of Diabetes and Digcsrive Dr. John B. Robbins "Fo1· 011tsta11di11g co11trib11tio11s ill the area of and Kidney Diseases Chief, Laborarory of Developmcnral and h11111an vi1'(II carcinogenesis in sftldies 011 the mecha­ ''In recog11i1iun uf exceptional dedication, judg­ Molecular lmmuniry nisms of transformation a11d tramcriptional ment, leadership and innovation in fostering the National Institure of Child Healrh and reg11latio11 of the papil/1imc1vim1es. " mission of the Natio11al lmtitute of Diabetes and Human Development Oif!.estive and Kid11ey Diseases." D ·'For pioneering st11dies on the stmct11re and /tmc­ Dr. Harvey G. Klein tion nf bacterial virnlence factors. leading to the Chief, Deparcmenc of Transfusion Medicine New Science Journal Launched development of a new generation of vacdnes for the Clinical Center prevention of pertussis, typhoid fever "nd H. illf/11- "In recog11itio11 of his 011tsta11ding leadership, for Cytokine, a new journal, wil! be published enzae meningitis." his m11mlcttive and crucial role in advancing blood by W . B. Saunders Co. Chief edicors are Drs. relctted ,·esearch, he11101herapy and the development of Score Durum (NCI) and Gordon Duff (Univer­ Merirorious Service Medal national blood policy .. , sity of Edinburgh), with edirorial offices in Washington, D.C., and Edinburgh. Other Dr. Roberr S. Adelstein Dr. Frederick P. Li N IH members on the editorial board include Chief, Molecular Cardiology Laboratory Head, Clinical Studies Secrion Ors. Warren Leonard (NICHD), Joost National Heare , Lung, and Blood Institute National Cancer lnstirure Oppenheim (NCI), William Paul (NIAID) "For his continued outstanding contribution to "for 011/Jtanding contrib11tio11s to cancer 1·esearch. and Steven Rosenberg (NCI). A large number the st11dy of the role of contractile proteins in smooth including the linkage of 111111s11al clinical and epi­ of scientists from ocher instirutions in rhc mmcle and 111mm11sde cells .,, demiologic observations to laboratory research which United Scares, Europe, Japan, Canada and is ,·eveali11g previo11JI)' 1mk11rn1'11 111echa11is1m of Australia will also serve on the editorial board. Dr. Jeffery L. Barker h11111a 11 1'(1rfi11oge11esis. " Cytoki11e will publish original research of Chief, Laborarory of Neurophysiology high quality on molecular biology, cell biol­ National lnscirure of Neurological Disorders Dr. Preston A. Licrleron, Jr. ogy, in vivo and clinical levels. Reviews and and Srroke Deputy Direccor, National Institute of Deneal .-ibscraccs of relevanr mcccings will also be "Fr>r outstanding achievement cmd i1111011atio11 of Research published. Subject areas include interleukins, new and insightft,I strategies ill 11e11roscienre that Deputy Chief Deneal Officer, USP HS interferons, cycotoxins, hcmopoietic and have Jif!,nif,ca111ly ft1•·thered om· 11ndersta11ding of ·'For noteworthy career acro111plishme11ts and growth factors and related or new cyrokines. A the ve,·tebmte central ne,-vous sysmn." leadership initiatives which have substantially major aim of the journal will be co encourage i11/l11enred the ft1t11re of de11tal health in the U.S." communication among different specialties. Dr. Michael Boyd R. The first issue will appear in November 1989, Associate Director, Developmental Therapeu­ Dr. Donald L. Loriaux and a call for manuscripts will soon be tics Program Chief, Developmental Endocrinology Branch, annoum:ed. National Cancer Institute and Clinical Di rector For further information, contact Cytokine. •·For the development of i11novative screening sys­ National Institute of Child Health and W _ B. Saunders Co., The Curtis Cenrer, Inde­ tems for idmtifyi11g 11ew agents for treati11g cancer Human Development pendence Square West, Philadelphia, PA ,md AIDS... ·'Far exceptional research achievements and exe111- 19106-3399 (rel. 2lS-238-7800). 0 p/a,-y leadership in the developmem of an integrated Dr. Eileen G . Hasselmeyer progra111 of i11vesti!{atio11 co11a11tratil1f!. 011 the disor­ Associate Direcror for Scientific Review, ders of the endocrine system in the young." NIH R&W Picnic, June 4 NJCHD Special Assistant to the Director, NCNR Dr. Kenneth C. Lynn All R&W members and their families arc "For expe,·t advice and 011tstanding leadership in Chief, Research Dara and Management Infor­ inviccJ ro join in on the fun at the NIH assisting i11 the estahlishment of the National Cen­ mation Section R&\XI annual fam ily picnic. The event is ter for N11rsing Research, and for leadership and National lnsrirure of Deneal Research scheduled for Sunday, June 4, ar the Bethesda acco111pli,hment in the creation and development of "I 11 recog11itio11 of an effective career dedicated to Naval H ospital picnic area from noon until 6 the SI OS research program at the National providing mential dented research data to the scien­ p.m. (rain or shine), and wi ll include plenty lmtitute of Child He.t!th and H11111a11 tific commm1ity and the p11blit' at lctrge . .. Development ... of food and games for all. Tickets are $2 for R&W members or 35 for a member and fam­ ily, and can be purchased ac any R&W Gifr Shop. For more information, call 496-4600. □ page 7 The Record May \0, 1989

Roth Receives Honorary Degree from Italy Peer Review in Science Writing

NIDDK scientific director Dr. Jesse Roth example to them. Thar's why we thought rhe Dr. David A. Kronick, currentl y NLM 's has been awarded one of Italy's highest aca­ University of Rome should recognize him in visiting historical scholar, will speak on Tues­ demic honors, an honorary doctoral degree in this way. " day, June L3, at 2 p.m. in the Lister Hill medicine from the University of Rome. Roth As a researcher in N IDDK's Clinical Endo­ Auditorium, Bldg . 38A. His topic will be received the honor in recognition of his crinology Branch, Roth and coworkers research on insulin receptors and peptide hor­ pioneered the study of cell surface receptors. mones and for the consistent support he has In l969 Roch, rogerher with Ira Pascan, g iven to Italian researchers over the years. Dr. William Pricer and Robert Lefkowitz, was the Giorgio Teece, rector of the University of first to measure a hormone (in rhe form of Rome, presented the degree at a recent cere­ radioactively labeled ACTH) binding to a cell mony in the university's main hall. surface receptor. The concept of a cell surface "Jesse is well-known for his research on receptor represented an entirely new way of insulin receprors and conditions of insulin understanding rhe accion of hormones on resistance. He gave imperns to new ideas that target cells. have been pursued by people all over rhe Roth's laborarory was also the first co study world. His work opened a new field of the receptors for insulin and human growth hormone. In addition, their work became the model for lacer studies showing chat many other hormones also bind ro receptors on rhe surface of cells. In his pioneering studies of insulin receptors, Rorh and his collaborators, including Dr. Phillip Gorden, NIDDK direc­ cor, showed that receptors were highly Dr. Dtwid K,-onick regulated and were able to alter their sen­ sitivity in response to internal and external "Peer Review in Scientific Journalism: A His­ cues. Rorh and coworkers were the fi rst to torical Review." All N IH employees, along describe disorders of cell surface receptors in with the general public, are cord ially invited. disease stares in both animal models and in Kronick is on leave from rhe University of humans. In studies of patients with extreme Texas Health Science Center in San Antonio. insulin resistance, they described several pre­ A medical librarian and bibliographer, he is viously unrecognized conditions involving the author of History of Scientific ,md Technical defects at the level of the insulin receptor. Pe,-iodicals, the standard work on that subject. "Jesse has had a major impact on the For more information, call 496-5405. D thought processes of people in the field ," according to Dr. Simeon Taylor, a section D,-. J em Roth chief in NIDDK's Diabetes Branch. ·'Nor only research," said Dr. Dominico Andreani, presi­ has he helped many Italian scientists, bur it's dent of Italy's Endocrine Society and director always srriking ro me how many productive of the Second Medical Clinic ar rhe University researchers in the field throug hout the world of Rome. "Also, Jesse has always helped a owe a debt co Jesse." D good many Italian researchers. He was a g reat

Weicker To Address NIH Alumni

Sen. Lowell P. Weicker, Jr. , will be the Centennial celebration. T he local Washington speaker at the spring meeting of the National chapter has more than 400 members. NIHAA Institutes of Health Alumni Association recently published a newsletter, the N IHAA (NIHAA) on Thursday, June 8 from 5 co 7:30 Update, and has launched a national member­ p.m. at the Mary Woodard Lasker Center (the ship d rive. Cloister). Anyone who has worked or studied at NIH Dr. Reed V. Tuckson, commissioner of p11blic Weicker, the president and chief executive is eligible co join NIHAA. The primary goal he,dth in W a.rhi11gto11. D. C., will be the keynote officer of Research' America, will talk about is co enable former staff to maintain contact speaker al 1he program, "What To Do When a rhe newly formed nonprofit organization that with NIH and friends and colleagues in the Coworker Has AIDS.'' begi11ni11g al 10 a.Ill. rm he leads. His topic will be ''Research! Amer­ scientific community. Present NIH employees Friday. J1111e 2 in Mas11,- A11dito.-i111n. Bldg. IO. ica-An Alliance for Discoveries in Health ... can become associate members; past NIH Employees at the Westwood Bldg. and Exec11tive Light refreshments will be served and rhe cost employees can become full members. In each Plaza .rhould be aware of the addition of a 3 p. m. is $10 per person. Guests are welcome. category the membership fee is $25 per year. shuule bm leaving Bldg. IO fo r those desri11atio11s The NIHAA was reestablished as a result of For further information about rhe June 8 after the program; the res/ of 1he bus sched11/e interest expressed by alumni during the NIH event or NIHAA, call 530-0567. 0 remaim as published in the las/ Record. l"'lle 8 The Record May 50, 1989

RECORD That issue sec the mne for rhe next 28 MOLE HUNTERS UNCOVER (Continued from Page 1. ) years, when the l?ecord would adopr a for­ mality approaching char of a scholarly journal . TNT BURIED AT NIH Two NIH emp10yees, tracing award stories, personnel notes (every new The neighborliness and conviviality of the mole tunnels out of idle curiosity, employee was named in alphabetical order), l?,:cor,/'s first decade were exchanged almost recently uncovered something more R&W notices (including ubiqL1irous invita­ overnight for a more sober and serious journal­ impressive than rodent life--a tions co join rhe ·'NJH Hamsters," a rhcarcr ism char favored hard news over personal iry . small box of dynamite buried in the group) a calendar of events, and general The shifr was undoubtedly appropriate, . woods in front of N I H. notices from the institutes. given thar the instirution---11nd irs attendant The lunch hour episode involved T he second page of every issue during the bureaucracy- was growing by leaps and Murray Eden and Alvin G. McNish first few years was headlined " Research bounds. Some 7,600 employees were working of the Biophysics Se c ti on, NC I. Acciviries ... ·· and was divided into descrip- ar NJI I when the Record traded rhe shirtsleeves While walking through the wooded area between Road "A" and the main NIH road on May 10, they 6/inical ~eactions and t:olerance to £St) May 28, 1951 worked together for a long time. While we in 61tronic Scltizoplt renia spoke of scientific achievement, we d id not speak of scientists; and roo infrequently we No. 140 in a Ser~es May 18. 1955* d id not speak (sic) of the vast m1mbers of NIH people who make scientific research of folksiness for rhe blazoned robes of the possible." tions of intramural work and "Science ivory cower. The remedy was to create two new feature Elsewhere." News from rhe former category If it was a shade less serious rhan its suc­ columns. "NIH Spotlight" focused on rhe w,,s marshaled into a numbered primer with cessor, the first decade of rhe Retord was lives and personalities of NIH 'ers, many of such rid es as "Studies in Chemotherapy of norablc for irs good nature and occasional lit­ whom were women whose appeal was plainly Malaria" (No. I ) and "Studies in Amoebiasis'' erary flair. And for reporting that reflected rhe and unembarrassedly noted. (No. 2). The intramural column lasted until exuberant sexism of rhac more innocent (if For example, " A very pretty blond in t he Sept. 28, 1959, when No. 2J2-"Polyoma perhaps more ignorant) age; consider rhe story Office Services Section of NCl has attracted Cancer Virus Work Progresscs"-cnded the * Dau~ of Nerord issue the admiring glance of a phorographer more series. Two issues airer the primer series ended, on SHANNON THE MAN Oct. 27, l 959, the Record underwent the big­ gest change in its 40-year hisrory. Ir gradu­ ated ro its current d imensions (81h by LI Clash of Wits, Basket Fires inches), doubled in size from 4 to 8 pages, included 4 columns on each page instead of _:,, Often Marked Morning Staff and exchanged pedestrian newsprint for a Aug. 20. 1968 slick, matte finish that gave ir che luster of a magazine. "And Now Our Girls Are Throwing Curves," than once," characterized Helen M . Duvall in The change was page one news: "Record from page one of rhe July l , 1949 issue: the issue of June 23, 1952. Myra F. Embrey, Presents 'New Look,' More News, Science Sec­ "Yes, indeedl Those curvaceous ballplayers Miss N[H of 1955, had the following editor's tion," read the headline. you saw as you left the grounds rhe orher eve­ note appended to her profile: "(Ed. Note for " Wirh this issue, the NIH Record appt,;irs in ning were g irls ... Unofficial captain of the Men Only: Myra is neither engaged nor going new size and garb, marking che first basic newly organized club is Mrs. Dorothy Win­ sready-as of press rime, rhar is. )" T opping change in format since the Number One issue nie, NCI technician of Bldg. 6. And she them al l is chis lead scnrence from rhc NIH came off the press on May 20, L949," wrote swings a mean bac .. _ (The versatility of rhese Spotlight of Sepe. 14, 1959: "Looking more the reporter, probably editor Elizabeth D. girls is simply amazing. Ir was a most pleas­ like the gay, attractive girl nexr door than a Mok. ant assignment for chis reporter to observe.)" Doctor of Veterinary Medicine, Sara Jane On the occasion of the Remrd'.r first anniver­ Uhri ch is well-embarked on a career heretofore sary, rhc editor (probably William T. largely pursued by men." -'• Carrigan , who succeeded first editor Alexander .N if Adler) cast a critical eye on his work and ..,~ R&W NOTES offered rhe fo llowing assessment: "Glancing back ac past issues, we rhoughr ANTI-VIVISECTIONISTS Coca-Colas from R & W vending thar some things had turned our happily. The machines will now be $.10. The Rernrd had rnme ro have a good, crisp look THROWN ON DEFENSIVE rising cost of cokes and continued about ir, and generally ir had managed co Nlli research achievements were bottle losses make it impossiblefor keep people infor;11cd about the doings of our cited during r ecent Congressional R & W to continue to absorb this hearings as evidence in favor of a loss. As you know, profits from scientisrs. law to authorize the use for medical vending machine sales help to sup­ "In some wa}'S, however, we thought ir bad port recreational activities for NIH failed . in particular, the Rewrd had not research of unclaimed dogs from employees and to maintain the Pa­ achieved that sense of domestic intimaq, the District of Columbia pound. tient Welfare Fund. Apr ._29, 1957 which characterizes rhc life of people who have June 17, 1949 page 9 The Record !\fal ' .,0, I 989

had since Feb. 9, 1953. Or drop by our NIH Will Install Two Cyclotrons, Its First Ones offices in Bldg. 31 , Rm . 2803. O ur record of Feb. 12, 198; l?eco,·d stories, based on subject and name. is surprisingly comprehensive.- Rich McManus Were the same sentence co appear today, commentary chat characterized its first days, the edicor would be well-embarked on the however, and by the occasion of its 10th anni­ search for his next job. versary had arrived at both a starchier sryle T he second feature, " Here and T here," and its sixth editor. FOR MEN ONLY provided a "commentary on various aspecrs of The editions of the early sixties closely Summe r at NIH, we under stand NJH life." Since bylines were nor ro appear in resem bled rhe old \Vashington Star news­ from one of our correspondents, che Rero,·d for another decade (starting midway paper-pages busy with copy, a variety of has suddenly made its appearan1:e t hrough 1960 under editor E. Kenneth Stabler headline styles and faces, and a layout whose behind T -6. Our correspondent, a and occurring haphazardly since), it is hard co chief presumption muse have been rhar no male, tells us that the f:d r ls are assign credit for the following examples of story was so unimpurranr char it couldn't wait lunching there on the grass, and rather wistfully underlines the fact curmudgeonliness. for the next issue. Pages were becoming as that the girls are alone. June I 9, I?S O

Dr. Judith Resnik, Former Staff Fellow 1-6 Routs Slcunlc In .Scented Struggle In NINCDS Lab, Selected as Astronaut A skunk lost h is bearings and Dr. Judith Resnik, former staff fellow of the NINCDS Laboratory wand e r ed into Building T-6 re­ Neurophy~iology, is one of 35 astronauts recently selected for the Spa, cently, causing quite a com motion Mar. 7, 1978 and something of a stench , Mar. 19, 19;!

From rhe informal column, "Let's Swat Phone Links President and Patient Flies": "Mayo Beach is particularly suited for Ju ly 6, 1982 fam ilies with small children and, as a matter of fact, adults unaccompanied b)' child ren are not allowed through t he admission gate. T he 95° TEMPERATURE IS water at Mayo is quite shallow and there are crammed as the campus. swings, slides, and sand boxes co temporarily For the past 30 years the Record has had a PEAK FOR TIME OFF distract ch ildren from their ultimate dest ruc­ masthead naming staff correspondents from an tion of a quiet afternoon ... ever-increasing number of bureaus, institutes General e xodus of employee s be­ From " Herc and There": "While our inter­ and divisions. In the same period there have c i u,-;,, of hot weather s hould be non­ Px1 stt• nl or rare, according to a est in nat ure is comparative!y sl ighr, we been a variety of cosmetic changes, the most pol iq· statr·m('nt by Federal Secu­ cannot help remarking with ochers on the recent having occurred in September 1985. rity A).:cncy o[[icials. E.~c,•pl for l'Xlremc eme rgency c·c111d1t1C,,,.-s , ;:rvups will be dis­ n.1ss1·d only whl'n the temperatur e CODE OF ETHICS ESTABLISHED BY CONGRESS r• ·a('ht•~ 950 a nd the humidity hits :;') Jh' rt't•t11. Congress recently established the a ccept, for himself or his family, Thus,· who s uffe r from t he heal following "Code of Ethics for Gov­ favors or benefits under circum­ :-chuuld ;.:11 lo their health unit fur e rnment Service ," listing principles stances which might be construed of conduct for all elected and ap­ by reasonable persons as influencing Jul)' 31, 19 50 pointed persons in Government: the performance of his governmental Irishman louts Snalce . Any person in Government should duties. Jan. 5. 1959 Reconnoitering Bldg. 6 Like Saint Patrick, who fear­ lessly drove the serpents o u t of Ireland, NC l's Ve rnon Riley is no large number of whippoorwills in Silver Through it all, the Record has remained pretty man to yield ground to a snake. Spring and Bethesda who have been d isturbing much the same useful organ it was when it On a recent Saturday midnight, the nig ht's repose. Comes the first shade of firs r appeared 40 years and 12 edirors ago. he met up with a five- foot black dusk and off they go into chat peculiar sad, Bur don't rake o,1r word for it. A readership fellow slithering through the foyer survey undertaken by the University of Mary­ of Bldg. 6 -- no doubt preparing to sad call which they repeat and repeat, it ease the joint in search of a tasty seems, withom interval throughom the night land's College ofJournalism in 1988 mouse or two. .. . T he whippoorwill's cry, we fee l, is mo concluded that N IH'ers read and enjoy their With fine Irish instinct, Biologist purposive for miracle; in facr, it is just newsletter. Riley promptly sent the marauder another reminder of how perfecrionisr we can If chis brief notice of our anniversary has packing. The snake, sensing the futility of trying lo outs mart a true· gee in working our ways and means of bother- piqued any reader's interest, further derails of son of Eire, offered no resistance . . ing our neighbor." l?ecord history may he gained by calling exten­ A few days earlier, another The Rernrd was soon weaned from che breezy sion 2125, t he same number rhe paper has June i';, 1951 page 10 The Record May .JO, 1989

DIRECTOR "anJ I began co consider che position more Because of his extensive university back­ seriously. My friends said char I would have co ground, Wyngaarden began co perceive a role (Continued from Page I. ) cake it if I gor the offer. as director that would cake advancage of his experience as an educator and of his knowl­ initiative-has hegun under Wyngaarden's "I had a very keen awareness of how abso­ lutely crucial NIH was to che conduce of edge of both camps-government and leadership. Amid chis record of accomplishment, cwo biomedical research all over the world," he academia. chings stand out. First, it almost didn't hap­ said. "And I had a great admiration for rhe "I soon recognized a very substantial and pen. And second, the aforementioned intramural research enterprise here--ir is as dangerous gap in understanding of N IH pol­ triumphs arc nor the proudest feathers in imporranc to protect as the extramural side. It icies between the intramural administrative Wyngaarden's cap. seemed like as good a rime as any co accept a staff and t he universities," he said. " Boch were "After I announced my resignation (on Apr. new challenge." absolutely sure that rhey knew the ocher thor­ 20), some members of Congress called co A lifelong Democrat, Wyngaarden accepted oughly, but neither percepci.on was accurate." thank me for the job 1 did," said che direccor President Reagan's invicacion co direct NIH, For example, while NIH was largely in a recent interview. "l ended up thanking but he was no Reagan idealogue. unaware of the number of scientists leaving chem more for their support. They said that I "Jc wasn't one of my 061eccives co hold science and academic medicine on university brought credibility to the position and that down che federal budget," he says. campuses, the universities were likewise chey knew I wouldn't do anything foolish. I In February 1982, Wyngaarden began what unaware of che funding restrictions imposed choughc chat was kind of a nice scarcment." was co be the longest term of any N IH direc­ on NIH. Pride in having lived up co the public trust tor, save Dr. James A. Shannon, since the "The universities were policically naive,'' he emerges as Wyngaarden's most treasured suc­ 1940's. He also learned he was in for cwo big said. "They did noc realize chat our budget is cess. Bur he did not want that burden when it surprises. so rigidly organized. We have 19 budgets that was fi rsr offered. The first, he says, is "the degree to which are inscirute-specific and mechanism-specific. Former NIH deputy d irector Dr. Thomas NIH is tethered co rhe department (DHHS). le is ver)' detailed and you can't move money Malone, in introducing Wyngaarden back in around very much." 1982, said that a g lance at Wyngaardcn's Wyngaarden said a "dangerous antagonism" resume made it look "like he was being was developing between the two sides. groomed for the director's job righr from che "The universities now have a much better scare. understanding of what NIH is. Conversely, we He had been chief of the medicine depart­ have a better understanding of their ment ac Duke University for l 5 years ("\Y/e problems.•· were almost totally funded by NIH at Duke," T he director says he cook a loc of flak for he says) and had held the same pose ac the traveling around the country co give lectures University of Pennsylvania from 1965 co at universities and medical schools in his early 1967. He was a research associate at NIH years. from 1953 co 1956, serving cwo insciruces, ''Those weren't pleasure trips," he said. "I NH! and N IAMD. He had been named ro a think my liaison work has paid off. I'm cold variety of science policy boards, ranging from chat I've brought some scability co NIH . I NLH smdy sections, evaluation committees chink char·s what happens when you cry to and srndy panels co the National Academy of NJH director Dr. James B. Wly11gaanl.e11 meetJ have consistent policies chat everyone Sciences, che President's Office of Science and u-ith then Vice Presidem Gem·-ge Bush at NIH 011 understands." Technology and the President's Science Apr. 8. 1987. Wyngaardcn's appreciation of policy issues Advisory Committee; this in addition to inter­ has roots in che early l950's, when Dr. James nationally recognized research on gour and A . Shannon recruiccd him to che PHS and ro coauchorship (along with Dr. Donald lab space in the newly opened Clinical Center. Fredrickson, who immediately preceded him as NIH director) of The Metabolic Basis of le seems as though every decision is sccond­ "J was just trying to learn how co do good Inherited Diuaie. guessed, delayed or not acted on. Ir's almost science in chose days," he recalls. "I had no In shore, he was a golden candidate for the impossible for rhe director co direct because he concacr with the duties of the director, though NIH director's job. Bue he didn't wane it on himself is being directed." cwo or three times Dr. Shannon asked me co first blush. The second surprise was the ubiquity and do some favors. I knew the job involved fund­ . "Ed Brandt (then DHHS assistant secretary tenacity of special interest groups, including ing responsibilities and Congressional for health) called me ar Duke co discuss che myriad voluntary health organizations. responsibilities. NIH at that time was suffi­ job, but I declined at first," Wyngaarden "They are exrraordinarily interested in any­ cicncly small and new chat it was given a lot recalls. "It wasn't something char .I had thing that we do," he re laced . "No matter of larimde co develop." applied for." what decision you make chat favors one group, The political nature of the job became Friends and colleagues urged him re) cake you arc sure co hear about it from che others." apparenc around l960, he recalls. the offer seriously. At che rime, an inept During his first year, Wyngaarden was del­ "T he first major oversight committee was administ rator had raken over rhc Veterans uged with courtesy visits from these agencies. che Fountain Committee," said Wyngaarden, Adminisrrarion and was slashing its research ") started co wonder when chey would end who at the time was ac Duke, teaching medi­ budget co rhe bone. Fear char similar manage­ so l could gee down to doing the director's cine and biochemistry and directing a medical ment could be foisted on NIH prompted job." research craining program. Wyngaarden co heed his associates' advice. lesson three: "Much of che NIH director's ''The committee was mildly horrified ac che " My name appeared in the New York Ti111es job is representarional-co rhe Congress, co degree of freedom given to NIH-supported on a shore list of candidares," he recalled, the public and to the administration." scienriscs. There were a loc of lawyers on the pa)(e 11 The Record Maj• .W. 1989

nize char scientists are different from field Clinical Chronobiology Symposium officers"); planning and building new facilities for various instirnces-che 3,000 employees The National Institutes of Heal ch and che now in rental buildings in the area are slated International Society for Chronobiology are to occupy the Consolidated Office Building cosponsoring a symposium, "The Clinical due co be b uilt in corning years ("Bring ing Applications of Chronobiology ," co be held on people back co the campus will allow chem co Thursday, June 20, from 8:25 a.m. until 5:30 take advantage of rich contacts hcre"}--also, a p.m. in the Lipsett Amphitheater of che Clini­ new N ICHD faci lity, Bldg. 49, will scare cal Center. The conference, cosponsored by going up in June, and three new floors in N IAMS, NCI, NICHD, NIDDK, NIGMS, Bldg. 10 will help AIDS research; naming NHLBI, N IMH and NCNR, will feawre new directors for all but three institutes, and speakers from the United Scares and abroad . appointing mosr of chc deputy and associare Chronobiology is rhe scientific scudy of bio­ directors in Bldg. 1 ('" I think we have suc­ logical rhythms and their measurements by \Vyngaardm giz,e.r Presidml Ronald Reagan an ceeded in gcccing really- excellenr people"). analytical scaciscical methods. T he symposium 11pdate on AIDS research dm·ing !he president's visit Asked the hardest decision he had co make will focus on che clinical applications of chro­ hereonj11ly23. 1987. as director, Wyngaarden g ives an insight into nobiology to improve diagnosis and treatment his values: of a variety of diseases. Subject areas will in­ " When I appealed co Secretary Bowen to -elude the following: immune disorders, sleep disorders, psychiatric d isorders, cardiovascular commiccec. They understood contracts, but keep Dr. Edwin Becker from being banished ,diseases, graft vs. hose d isease, ulcer disease nor grams-in-aid." from NIH (owing co an investigation by che and cancer chemochcrapy. Wyngaarden says this was "chc first time DHHS inspeetor general char found irreg­ Chronobiology has opened new avenues in N IH was impressed wich che requirements of ularities in procurement), I had to go over the the understanding of normal functions of the accountability. The theme has been ratcheted heads of everyone above me in the depart­ body. le may have wide application in under­ up since then. Dr. Shannon's freewheeling ment. Jc was my most difficult moment. Bue standing the development of certain diseases, management style disappeared seep by seep I'm g lad .l did it." 0 and in t he treatment of many conditions with and I don't chink we'll ever see it again." drugs and ocher t herapeutic agents. Though it won't be remembered as free­ Katz Named to Sulzberger Chair The NIH has certified this symposium as wheeling, Wyngaarden's management scyle meeting the criteria for 6. 5 hours of Category bas been forceful, persistent and, at times, Dr. Stephen l. Katz, chief of NCI's Dermatology 13ranch , has been named Sulz­ J CME credit. outright stubborn. As he approaches his last To register for che symposium, contact Dr. months in office, he is about as satisfied as a bt,rger professor of dermatology ac the F. Edward Hebert School of Medicine of the Uni­ Kirc Vener, Westwood Bldg. , Rm. 5A07, man can be who, all ocher accomplishments formed Services of the Health Sciences phone 496-0754. 0 aside for the moment, chinks research is (USUHS). Dr. Jay P. Sanford, dean of che underfunded by about a billion dollars a year. med ical school, announced che appointment "We're about $ l billion short of having che that will combine the Sulzberger professorship support level of the early I 970's," he said. At with Katz's current NIH position. that rime, NIH could fund 45-50 percent of Sanford acknowledged, "_)use as Dr. Sulz­ approved grant applications. berger was a great reacher and at the forefront "We've been in the high .W's, buc we're in dermacology of what has become known as slipping well below chat now,•· he observed. technology transfer, Dr. Katz excels as a N IH is underpaying the crne cost of re­ reacher, a researcher and as a clinician." search ac about 10 percent for grants and 15 The Sulzberger chair was created in memory percent for centers, he said. "We've put vir­ of Dr. Marion B. Sulzberger, a military as tually nothing inco general extramural well as civilian leader who pioneered in the conscruetion since che l 960's." development of dermatology in che United On the bright side, che number of research Scares. project grant applications receiving funds has Katz, an internationally recognized der­ risen from 15,000 at the scare of his tenure co matologist and researcher, has been a professor Dr. Gilbert Ashu,efl of NlDDK's Labo,.atory of around 21,000 now. The average grant length of dermatology at the Hebert School of Medi­ Biochemistry and Metabolism has received the Seninr has increased by a full year in rhat rime and a cine since 1984. The Sulzberger appointment U.S. Scientist Award from the Alexander von variecy of new grant mechanisms rhar are represents USUH S's first named chair. 0 longer, renewable, and chat reach different H11111bo!d1 Fo11ndation of the Federal Republic of Cem1any in recognition for his WOl'k 011 the asialo health fields have been inscicuced. R&W Offers Harbor Cruises "On chc intramural side, I got S LO million glywprotein. a receptor found 011/y rm liver cells. for a project examining che structural biology When you cr uise che Inner Harbor on the The Humboldt Fo1111datio11. whose pmpose is to pro­ of the AIDS virus," recounted the director. Bay Lady you'll enjoy dining, dancing, lively mote the exchange of ideas a111011g American and "Thar brought about LOO scientists from ocher entertainment and a scenic cruise. Make reser­ \fl eJt German investigators and research instit11- fields inco AIDS research." vations at che R&W Activities Desk and tions, will pravide abo11t $30.000 toward Wyngaarden also counts as victories: pre­ receive a IO percent discount (applies co most Ash-welts expmre.1 for tl'ave! and a 6-111011th stay to venting Surgeon General Koop's revitalization daces). For more information, visit t he R&W cond11rt mearch al the Free University in West of the Commissioned Corps from demoralizing Accivicies Desk (Bldg. 31, Rm. B l W 30) or Berlin. scienriscs here ("We helped t he corps recog- call 496-4600. 0 page 12 The Record May 30, 1989

12th Annual Institute Challenge Relays Draw 500 Pounding Feet

A coral of 250 runners participated in the 12th annual lnsticute Challenge Relays held May 17 in front of Bldg. I, sponsored b>• the NIH Health's Angels Running Club. Under skies that turned from gray co blue just before N IH deputy d irector Dr. W illiam Raub fi red a srarcer's pistol for the first heat, runners of var>•ing ability began their circuit of Bldg. 1. The all-female team, NJMH"s "Fusion in a \Vi1111ers of the mixed team competition we,·e (f,·ont . Shoe," which included Ingrid Hutter, Anne from I) Steve Miiler, Tony Brown, Charles Argo/f. Andrews, Jennifer Spahn, Celeste Baucom and J anette Lagros, won ics division in the very At rear are (f,·om I) Cathy Mcl~ellan and Alison fi ne rime of 16:30. \Viehman. The second heat, started by Sgc. Reginald G lenn of the N IH Police, was contested by the all-male teams and the more experienced mixed teams. T he male division was won by NlDR's 1989 "Mal Declusions" with Peter Burbelos, Lloyd 12th ANNUAL NIH INSTITUTE Mitchell, Jack Shawver, Lou Mocca and Pierre CHALLENGE RELAYS Savagner in a very fast time of 12:26, the swiftest rime run by any ream at this year·s TIME TEAM NAME INST. race. MIXED TEAMS "Tony's Striding Aces" of NINDS won the 13:08 Tony's Srriding Aces NINOS mixed ream division in 13:08, the third fast­ 14: l4 Cardio Express NJHFC est overall time. Members included Cathy Some 250 runnerJ ( i11cl11di11g the 111a11 pictured l<'i:.16 Recepcors cc Mclellan, Alison Wichman, Steve Miller, above a11d the UI0/1/an below) crossed the fi11ish line 14:43 Hot Fooces OD Tony Brown and Charles Argoff. at the relap. which were spomored by the NIH 14:44 Second Messengers NINOS Special thanks are again extended co the Health's Angels R111mi11g Cl11b. 15:27 Pulse Chase NHLBI many volunteers who make t his race possible 15:32 Pavement Epithelium NEI 15:38 Myosin cc each year.-Peter Pentchev 15:4 I Mega Dosers cc 15:45 Roll ing Thunder DFM 15:54 Urine Good Hands NHLBI 15:55 Microbes FDA 15:59 Or.I Six NIDR 16:07 Hean Throbs NHLBI 16: 14 I.ab Genetics NCI 16:25 Slowest Common Denominators N IH 16:29 Sloth Factors NCI 16:4 I TATA NHLBI 16:48 Champions DCRT 16:56 Pensioners N IAID 17:00 Epirnphs NCI 17: 18 Unaerobics N IMH 17:36 NIGMS NIGMS 17:46 Transp0n Pht!nOmtnon DRS 17:48 Occa Bombers NCI 17:53 Sherry's Nickles DCRT 17:55 Guys and Bases OSHB 18:0 I Dempsey's Dumplings ORG/ RRB 18:04 Troy OD 18:20 Be,wties and Bc:asts NHLBI 19 :06 Motility Faccors NCJ 19: 10 Fusion in Shoe NIMH Phoros: Ernie Branson, DRS D,dn'r Hnish Budge It NCI Alu•ayJ m,cial in the relays is skill in passing the baton. aJ these 11110 r1111111:rJ demo,utmte. iY.lf:C I l The Record May lO, 1989

ALL-FEMALE TEAMS

16.l 0 Fusion in Shoe N IM H 16:50 Hoc Dot Blots NIAID

ALL-MALE TEAMS

12:26 Mal Declusions NIDR 12:4'1 lmmunoselect NIAID l_l: 18 No Mean Feet DRS 13:49 Bio-Blowouts NCJ 14 : 12 Metabolites NCI 14: 17 Gu)'s aod Hicks NIMH l'i:45 Necrotic lc.'Sions NIAID 15:04 Horners NIAMS 15:09 Tic Now NCI 15. 19 Aussie Skipper-s NIAID 15:23 Feet of Endurance DRS 16:0 1 Five Pads NCI 16:52 Slugs NIAMS Dido'c Finish Pos Packe rs cc

A11 exhamted Lo11 Mocca pmses the baton to teammate Lloyd Mitchell in tt wh111i11g effort for the men .

Win11in//, the all-m,tle diviJion were (front. from I) J ack Sh,nuver. Lou Mocca and Urtyd Mitt-hell. At rear are (ji-0111 I) Peter B11rbelos and Pierre Saw,gner.

The ttl!-female division winners were (from. fro111 I) J ennifer Spahn, Janette Lagros. Celeste Bauco111 . At rear are (from I) Ingrid Hutter and Anne Andrews.

NIH dfp1tty director Dr. \'Viiliam Ra11b starts th; 12th annual Inte,·institute Challenge Relays with a pistol shot.

Spectators gathe,·ed at the start/finish line in front of Bldg. 1 lo cheer their favo,·ite teams to victo1-y. page 14 The Record May .,0, 1989

Vermund Heads AIDS NINOS Lab Chief Moves from Campus to Canvas Epidemiology Branch

An authority on the epidemiology of parasi­ After 34 years of making science his career tic diseases and sexually transmitted diseases, and rhe arts his hobby, Dr. William Adel­ Dr. Sten H . Vermund has been named chief man, chief of che N INOS Laboracory of of the Epidemiology Branch in the AIDS pro­ Biophysics since 197 l, has decided co rear­ gram of N IAID. range his priorities. The 61-year-old The Epidemiology Branch plans, imple­ neurophysiologist is retiring from the National ments and dircets a wide range of domestic lnsrirute of Neurological Disorders and Stroke, and international research activities involving moving co the Massachusetts seaside cown of studies describing rhe natural history of Falmouth, and making a fullrime career of HIV-l and re lated rerroviral infeccions. In painting with oils, acrylics and watercolors. addition, the branch administers invescigaror­ Neurophysiology, however, will not be initiated research grants in A1DS, HJY-related overshadowed entirely by hi s new career. diseases and opportunistic infections. Falmouth by no coincidence is only 4 miles Prior ro coming co NIH, Vermund was from the Woods H ole Marine Biological Labo­ assistant professor of epidemiology and social ratory where Adelman directed che daily medicine and pediatrics at Albert Einstein operations of the section on neural membranes College of Medicine in Bronx, N.Y. as pare of his NINDS responsibilities. Adel­ In addition, he served as a visiting medical man plans co continue his association with professor at City University of New York MBL. Medical School, and was adjunct assistant pro­ He is also editing a book on the g iant axon fessor of public health (epidemiology) at both of the squid, t he focus of mosc of his own Dr. William Adelman srndics as well as of many investigations he has overseen during his tenure as lab chief. prize-winning equations. This revision incor­ The squid's axon is a favored subject of nerve porates t he scrucrural and functional relations function studies because of its size. Adelman's between neurons and Schwann cells (a type of research has advanced scientific understanding cell that surrounds the neuron). of t he basic biophysics of nerve function , Adelman's investigations have also led co especially excitable membranes and sodium improved research techniques. For example, he and potassium channels. J evcloped several new methods for analysis of ln 1985, Adelman received a PHS Special structural images of nerve cells. Recognition Award for, among ocher accom­ Adelman received his B.S. from Fordham plishments, developing a new method for University, his M.S. from the University of studying soJium channel gating kinetics. He Vermont and his Ph.D. in physiology from also helped devise a major revision- and the University of Rochester.-Ka,hy improvement-of the Hodgkin-Huxley N obel Kranzfclder D Bowling Leagues Forming Government Day at Stadium The Bethesda Naval Bowling Center invites D,·. Sten Vemumd Government employees, their families and NI H'ets co join its 1989 summer league play. friends are invited to join in ·'Government All leagL1cs begin bowling che week of )Ltne 5 Columbia University and Cornell Universiry Employees Day '89" ac Memorial Stadium on and bowl for 10 weeks. For more information Medical College. Sunday, June 18 . See the Orioles vs. Oakland call che Bowling Center, 295- 2034. D Vcrmund earned his medical degree in 1977 (game time l :35 p.m.) at S 1 off che regular from Albert Einstein College of Medjcine. H e priced $6. 50 rickets. Plus receive a free Ori­ Volunteer Health Workers Wanted went on co complete a master of science oles 22 oz. travel mug. Order forms for the specially priced tickers can be picked up at degree in 198 l focusing on community health Mobile Medical Care has served the medi­ in. developing countries at the London School any R&W Gift Shop. T ickers should be or­ cally indigent of Montgomery Councy through of Hyg iene and Tropical Medicine. He also dered before June 5. Call 496-4600 for 7 clinics in southern Montgomery County holds a diploma of public health from the more information. D since 1968. Volunteer physicians, nurses and Royal Institute of Public Health and H ygiene sraff give medical care in afternoon and eve­ in London. In 1987, he received a master of ning clinics. Volunteers are protected by philosophy degree in epidemiology from Atlantic City Trip Maryland law. Physicians also are given free Columbia University. Presencly, Vermund is a malpractice insurance for their clinic work. candidate for a doccorate in epidemiology at Cash in on an Atlantic City trip Jui:-. ; ~ er Physicians who do only volunteer work in Columbia. July 8. Buses leave NIH Bldg. 3 IC at 7 a.m. Maryland may have cheir medical license for The author of m any scientific articles and sharp and return at approximately IO p.m. free. Nurses, laboratory technicians and book chapters, Vermund is a member of the Cost is $23/person (coin package and casino co adm111iscrative sraff are also needed. lf you Society for Epidemiologic Research, American be announced). Sig n up ac the R&W can lw 1p. pk s.: nil Mobile Medical Care, Academy of Pediatrics, and the American Activities Desk or an R&W Gift Shop. For 4,,0 ; ~~-,.. P,· ',m Hawley (work Society for Tropical Medicine and H ygiene. D more information call 496-4600. D '' .(. .1-858 I ). 0 rage I~ The Record May 30. 1989

~ TRAINING TIPS John Roderick Heller, Jr., Dies, Former NCI Chief ~ The NIH Training Center of rhe Division of Dr. J ohn Roderick Heller, Jr., 84, director bating cancer morbidity and mortality." Personnel Management offers the following: of the National Cancer Institute from 1948 co Heller left Sloan Kettering prematurely l 960 and president and chief executive officer after a paralyzing stroke, but remained active Co11rse1 and Programs Dates of Memorial Sloan Kettering Cancer Center as a consultant to the American Cancer Sociery Management a11d Supervisory 496-6371 from 1960 to 196/4, died in Bethesda, Md., and as a consulcanc on international affairs for Arritudes: How They Affecr Producuvity 7/1 1 May 4 of a stroke. NCI until 1980, when he retired. Crear,ve Uasics for Changing Workplaces 7/ I 2 The period during which Heller directed He was born in Fair Play, S.C., and was a Working Wi1h Personal Diffrrencts: l'v!BTI NCI was one of large budget expansion. NCJ's graduate of Clemson University and the Applications for Professional Developrncnr 7/ 19 appropriation jumped from $ l.8 million in Emory University School of Medicine. After Office OperaliollS Training 496-62 l l l947, the year before he became director, tO his inremship and residency, he joined che lnrroduccion to Working ar NIH for New S l l l million in 1961, the year after be left. Georgia scare department of health for a brief S,,pporr Scaff 6/ I 9 During his term as director, the medical perio

NOW AVAILABLE ON SHARE TRAINING FY 89 Training Center courses. NIH Tops Bestseller List

Access Wylbur and enter SHA RE Three of the ren most popular government Moms and Infants Needed TRAINING. First time users only, enter: books during April are NIH publications, x fr &ags2ugL.@@share(secup) on fi le37 according rn a Government Printing Office list The NICHD seeks nonemplo}•ed mothers published recently by the Washington Times with a first-born, healthy infant no older than newspaper. 5 months to parricipace in a study of social The NIH federal bestsellers are the National and cognitive development in infancy. Par­ Library of Medicine's C111111dated Index Medicm. ticipation involves two brief visits to mother NIH'ers Win Writing Prizes Vol. 29. 1988, which ranked first, and two and baby in the home. For more information, Narional Heare, Lung, and Blood pamphlets, call Rebecca Abrookin, 496-6832. D NIH rook three first place prizes in the fifth-ranked Eating to Luwer Your Blood Cho­ 1989 writing competition sponsored recently lesterol and eighth-ranked So You Have High by the mid-Atlantic chapter of the American Blood Cholesterol. D Medical Writers Assoc iation. Elaine Baldwin of the Office of Communi­ cations, NIAID, won first place in the category of booklets/brochures for a profes­ sional audience for her entry, "The Edge of Discovery." This brochure also won the D.C. Chapter and Internacional Award from the Society for Technical Communication. Mary Sullivan of the Office of Communica­ tions, OD, won first place in the category of booklets/brochures for a general audience for her entry. the women's health issue of News and feat11res from NIH. Writer Hugh McIntosh assisted with the issue. Patricia Newman of NCI's Office of Com­ munications won first place in che category of articles for a general audience with her encry, "The Cancer You Can See," published in The \'(lor/d Book Health and Medical Annual. And anorher NIH'er, Maureen Mylander of 0D's Office of Communications, has been installed as the new president of AMWA's NLH'ers bid on goods and services at the Patie111 Emergency F11nd A11ction, which recently raised more than mid-Atlantic chapter. D $10,000. The a11ction. which celebrated its fifth year, helps raise money for the patients at the Clinical Center. G11e1t Services , Inc. gracio11Jly donated the food sold at the a11ctio11. pa.~e 16 The Record May lO, 1989

Everything Down But Arrests Campus Crime Rate Falls; Security Branch, Employees Credited

The crime rare on the NIH campus has "We have gotten just superb cooperation property has declined by more than half com­ dipped some 2 5 percent below char for the out of che administration of the hospital," pared co last year. "The CC is doing extremely same 9-monch period lase year, and is down enthused Sweat. "They have spent the money well," said che chief. about 31 percenc for che first half of fiscal (co support Crime Watch, an employee Police recovered more than $25,000 worth 1989, said Jim Swear, chief of rhe Security security awareness program), made employees of scolen government and personal property in Branch, DS. available for lectures by our staff, posted signs the first half of chis fiscal year, Swear note

NIH Reaches Out to Native Americans Interested in Research Careers

Lase month, NIH and the Indian H ealth Northern Arizona University, who delivered Service (IHS) launched a new outreach effort che meeting's keynote address. co acquaint American Indian and Native Score's speech was encicled, "Future Native Alaska scudents with career opportunities and American Caretakers of the Cellular Environ­ training programs in biomedical research. ment." In the speech, he encouraged Native The new federal outreach effort got under­ American scudents to become involved in sci­ way Apr. 23 at a symposium in Phoenix, entific endeavors while also retaining their Ariz. , encitled, "Exploring Tomorrow's Fron­ connection to traditional American Indian tiers. " This .J-day event-designed as an cul rnrc. introduction to the various career paths and During the program, representatives from support programs in the biomedical and the various NIH inscicures and divisinns, as behavioral disciplines---accracted more than ... well as !HS components, the Food and Drug 300 hig h school, college and g raduate stu­ ,' Administration, and the Alcohol , Drug Abuse dents of American Indian and Native Alaskan and Meneal Health Administration discussed descent and their educators. research opportunities with students and their Students traveled from as far away as teachers. Maine, North Carolina, Californ ia and That evening, a variety of singers, dancers Alaska- from such universities as Dartmouth '.,.\./'I and drummers- all wearing native dress, and and Stanford-co actend chis first-ever fed­ representing che major cribes-parcicipaced m r • • ~"~ erally sponsored meeting for American Indian .,( . '· ' , J.::,;../4 a traditional Pow Wow . and Alaska Nacive scudenrs inreresced in pur­ As the symposium's closing event, con­ suing biomedical research careers. .~A~'- ference attendees visited cwo nearby research A traditional Pow \\1/(>I V was a highlight of the "The occasion marked the beginning of facilities: the Sacaton Service Unit at the Gila 3-day even/. what promises co be a productive collaboration River Indian Reservation, which houses between che NIH, !HS and Native American The symposium featured an incerescing IDDK and NIDR research faci lities; and the students," sa1•s program organizer Dr. Jay blend of traditional and modern American Phoenix Indian Medical Center, a large !HS Moskowitz, NIH associate d irector for science Indian culture. For insrance, on opening day, hospital that also houses an NIDDK research pol icy and legislation and acting director of side-by-side on chc program dais were Paul unit. D the National Institute on Deafness and Ocher Ortega, a Mescalero Apache medicine man Communicative Disorders. "1 look forward to who offered a traditional Jndian prayer, and the continued development and enhancement cell biologist Dr. Tacheeni Scocc, a member of of the program in future years." the Navajo tribe and an associate professor at l ~- ( iOVF.RNMFNT PRINTIN( , 0 1-FICl!. 1~9- 201- ""(fJ/80017