Figure S1

GFAPInd

NB +bFGF/+EGF NB -bFGF/-EGF nestin GFAP DAPI

(a) Figure S1 GFAPConst

NB +bFGF+/+EGF NB -bFGF/-EGF nestin GFAP DAPI

(b) Figure S2 +bFGF/+EGF

(a) Figure S2 -bFGF/-EGF

(b) Figure S3 #10 #1095 #1051

#1063 #1043 #1083 ~20 weeks GSCs GSC_IRs

compare

tumor-propagating capacity proliferation gene expression Supplemental Table S1. Expression patterns of nestin and GFAP in GSCs self-renewing in vitro.

GSC line nestin (%) GFAP (%)

#10 90 ± 1,9 26 ± 5,8

#1095 92 ± 5,4 1,45 ± 0,1

#1063 74,4 ± 27,9 3,14 ± 1,8

#1051 92 ± 1,3 < 1

#1043 96,7 ± 1,4 96,7 ± 1,4

#1080 99 ± 0,6 99 ± 0,6

#1083 64,5 ± 14,1 64,5 ± 14,1

G112-NB 99 ± 1,6 99 ± 1,6

Immunofluorescence staining of GSCs cultured under self-renewal promoting condition Supplemental Table S2. Gene expression analysis by Gene Ontology terms.

Names total elements #1051IR #1063IR #1083IR #1095IR #10IR 144 GO:0006810: transport GO:0006915: apoptosis GO:0005515: protein binding GO:0005789: endoplasmic reticulum membrane GO:0050896: response to stimulus GO:0006355: regulation of transcription, DNA-dependent GO:0007601: visual perception GO:0043565: sequence-specific DNA binding GO:0003676: nucleic acid binding GO:0007264: small GTPase mediated signal transduction GO:0006461: protein complex assembly GO:0007605: sensory perception of sound GO:0045202: synapse GO:0005730: nucleolus GO:0042475: odontogenesis of dentine-containing tooth GO:0043234: protein complex GO:0042734: presynaptic membrane GO:0006813: potassium ion transport GO:0005200: structural constituent of cytoskeleton GO:0007420: brain development GO:0030173: integral to Golgi membrane GO:0042803: protein homodimerization activity GO:0042127: regulation of cell proliferation GO:0016787: hydrolase activity GO:0030659: cytoplasmic vesicle membrane GO:0016757: transferase activity, transferring glycosyl groups GO:0005518: collagen binding GO:0001503: ossification GO:0040008: regulation of growth GO:0008134: transcription factor binding GO:0009611: response to wounding GO:0015293: symporter activity GO:0004872: receptor activity GO:0008380: RNA splicing GO:0005216: ion channel activity GO:0048306: calcium-dependent protein binding GO:0007268: synaptic transmission GO:0005575: cellular_component GO:0005622: intracellular GO:0016491: oxidoreductase activity GO:0016021: integral to membrane GO:0009055: electron carrier activity GO:0003779: actin binding GO:0008270: zinc ion binding GO:0017124: SH3 domain binding GO:0016324: apical plasma membrane GO:0006816: calcium ion transport GO:0005525: GTP binding GO:0045087: innate immune response GO:0009968: negative regulation of signal transduction GO:0008283: cell proliferation GO:0008083: growth factor activity GO:0005604: basement membrane GO:0046872: metal ion binding GO:0005516: calmodulin binding GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway GO:0005509: calcium ion binding GO:0008015: blood circulation GO:0003677: DNA binding GO:0019901: protein kinase binding GO:0007275: multicellular organismal development GO:0005578: proteinaceous extracellular matrix GO:0006886: intracellular protein transport GO:0005829: cytosol GO:0016563: transcription activator activity GO:0007186: G-protein coupled receptor protein signaling pathway GO:0006334: nucleosome assembly GO:0006357: regulation of transcription from RNA polymerase II promoter GO:0030054: cell junction GO:0005488: binding GO:0006811: ion transport GO:0031410: cytoplasmic vesicle GO:0005215: transporter activity GO:0001558: regulation of cell growth GO:0000287: magnesium ion binding GO:0045211: postsynaptic membrane GO:0016740: transferase activity GO:0005576: extracellular region GO:0008150: biological_process GO:0005769: early endosome GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0004930: G-protein coupled receptor activity GO:0005886: plasma membrane GO:0003674: molecular_function GO:0030154: cell differentiation GO:0050501: hyaluronan synthase activity GO:0007179: transforming growth factor beta receptor signaling pathway GO:0019717: synaptosome GO:0008285: negative regulation of cell proliferation GO:0012505: endomembrane system GO:0007267: cell-cell signaling GO:0005783: endoplasmic reticulum GO:0000139: Golgi membrane GO:0003924: GTPase activity GO:0009986: cell surface GO:0008152: metabolic process GO:0007417: central nervous system development GO:0016020: membrane GO:0004674: protein serine/threonine kinase activity GO:0005615: extracellular space GO:0031093: platelet alpha granule lumen GO:0006916: anti-apoptosis GO:0016337: cell-cell adhesion GO:0006457: protein folding GO:0006814: sodium ion transport GO:0005856: cytoskeleton GO:0030335: positive regulation of cell migration GO:0007528: neuromuscular junction development GO:0030199: collagen fibril organization GO:0003824: catalytic activity GO:0005624: membrane fraction GO:0007156: homophilic cell adhesion GO:0005524: ATP binding GO:0005540: hyaluronic acid binding GO:0005737: cytoplasm GO:0000166: nucleotide binding GO:0007399: nervous system development GO:0001726: ruffle GO:0004871: signal transducer activity GO:0005125: cytokine activity GO:0005882: intermediate filament GO:0030426: growth cone GO:0005529: sugar binding GO:0007165: signal transduction GO:0015031: protein transport GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0005634: nucleus GO:0007507: heart development GO:0005244: voltage-gated ion channel activity GO:0007155: cell adhesion GO:0003723: RNA binding GO:0005887: integral to plasma membrane GO:0005254: chloride channel activity GO:0005096: GTPase activator activity GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0006954: inflammatory response GO:0009887: organ morphogenesis GO:0008378: galactosyltransferase activity GO:0005201: extracellular matrix structural constituent GO:0005794: Golgi apparatus GO:0048471: perinuclear region of cytoplasm GO:0046982: protein heterodimerization activity GO:0005874: microtubule GO:0005507: copper ion binding #1051IR #1083IR #1095IR #10IR 6 GO:0045786: negative regulation of cell cycle GO:0008307: structural constituent of muscle GO:0051082: unfolded protein binding GO:0006397: mRNA processing GO:0000086: G2/M transition of mitotic cell cycle GO:0030145: manganese ion binding #1063IR #1083IR #1095IR #10IR 87 GO:0006950: response to stress GO:0044419: interspecies interaction between organisms GO:0004888: transmembrane receptor activity GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0001764: neuron migration GO:0042169: SH2 domain binding GO:0030879: mammary gland development GO:0042995: cell projection GO:0016607: nuclear speck GO:0007411: axon guidance GO:0005543: phospholipid binding GO:0003009: skeletal muscle contraction GO:0042476: odontogenesis GO:0008277: regulation of G-protein coupled receptor protein signaling pathway GO:0043197: dendritic spine GO:0004842: ubiquitin-protein ligase activity GO:0006511: ubiquitin-dependent protein catabolic process GO:0042493: response to drug GO:0007413: axonal fasciculation GO:0050806: positive regulation of synaptic transmission GO:0004725: protein tyrosine phosphatase activity GO:0030036: actin cytoskeleton organization GO:0031623: receptor internalization GO:0016042: lipid catabolic process GO:0051966: regulation of synaptic transmission, glutamatergic GO:0007218: neuropeptide signaling pathway GO:0006887: exocytosis GO:0015629: actin cytoskeleton GO:0030326: embryonic limb morphogenesis GO:0008092: cytoskeletal protein binding GO:0042472: inner ear morphogenesis GO:0005234: extracellular-glutamate-gated ion channel activity GO:0007596: blood coagulation GO:0006260: DNA replication GO:0005102: receptor binding GO:0043065: positive regulation of apoptosis GO:0008022: protein C-terminus binding GO:0005792: microsome GO:0045941: positive regulation of transcription GO:0015277: kainate selective glutamate receptor activity GO:0007018: microtubule-based movement GO:0045177: apical part of cell GO:0005654: nucleoplasm GO:0004437: inositol or phosphatidylinositol phosphatase activity GO:0001501: skeletal system development GO:0042802: identical protein binding GO:0016788: hydrolase activity, acting on ester bonds GO:0016363: nuclear matrix GO:0006936: muscle contraction GO:0003713: transcription coactivator activity GO:0051015: actin filament binding GO:0051260: protein homooligomerization GO:0009116: nucleoside metabolic process GO:0030018: Z disc GO:0030971: receptor tyrosine kinase binding GO:0003682: chromatin binding GO:0008104: protein localization GO:0007067: mitosis GO:0017111: nucleoside-triphosphatase activity GO:0051056: regulation of small GTPase mediated signal transduction GO:0016874: ligase activity GO:0030111: regulation of Wnt receptor signaling pathway GO:0001525: angiogenesis GO:0043005: neuron projection GO:0030424: axon GO:0003714: transcription corepressor activity GO:0042470: melanosome GO:0043687: post-translational protein modification GO:0007160: cell-matrix adhesion GO:0005667: transcription factor complex GO:0020037: heme binding GO:0007049: cell cycle GO:0005694: chromosome GO:0005544: calcium-dependent phospholipid binding GO:0008016: regulation of heart contraction GO:0019899: enzyme binding GO:0004859: phospholipase inhibitor activity GO:0019904: protein domain specific binding GO:0009897: external side of plasma membrane GO:0030139: endocytic vesicle GO:0051301: cell division GO:0009408: response to heat GO:0005625: soluble fraction GO:0030660: Golgi-associated vesicle membrane GO:0016459: myosin complex GO:0005975: carbohydrate metabolic process GO:0016055: Wnt receptor signaling pathway #1051IR #1063IR #1095IR #10IR 98 GO:0030674: protein binding, bridging GO:0007409: axonogenesis GO:0016481: negative regulation of transcription GO:0042310: vasoconstriction GO:0048246: macrophage chemotaxis GO:0031225: anchored to membrane GO:0006641: triglyceride metabolic process GO:0042632: cholesterol homeostasis GO:0030539: male genitalia development GO:0016323: basolateral plasma membrane GO:0008284: positive regulation of cell proliferation GO:0006958: complement activation, classical pathway GO:0005161: platelet-derived growth factor receptor binding GO:0004528: phosphodiesterase I activity GO:0007584: response to nutrient GO:0050839: cell adhesion molecule binding GO:0008233: peptidase activity GO:0006812: cation transport GO:0006869: lipid transport GO:0004867: serine-type endopeptidase inhibitor activity GO:0050656: 3'-phosphoadenosine 5'-phosphosulfate binding GO:0016477: cell migration GO:0006836: neurotransmitter transport GO:0030346: protein phosphatase 2B binding GO:0006979: response to oxidative stress GO:0006897: endocytosis GO:0008201: heparin binding GO:0030324: lung development GO:0005923: tight junction GO:0005813: centrosome GO:0019838: growth factor binding GO:0005085: guanyl-nucleotide exchange factor activity GO:0016023: cytoplasmic membrane-bounded vesicle GO:0043193: positive regulation of gene-specific transcription GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0005021: vascular endothelial growth factor receptor activity GO:0004176: ATP-dependent peptidase activity GO:0030505: inorganic diphosphate transport GO:0048008: platelet-derived growth factor receptor signaling pathway GO:0004252: serine-type endopeptidase activity GO:0030027: lamellipodium GO:0009653: anatomical structure morphogenesis GO:0007586: digestion GO:0016942: insulin-like growth factor binding protein complex GO:0008239: dipeptidyl-peptidase activity GO:0006952: defense response GO:0016192: vesicle-mediated transport GO:0016887: ATPase activity GO:0000278: mitotic cell cycle GO:0032869: cellular response to insulin stimulus GO:0045121: membrane raft GO:0006508: proteolysis GO:0042594: response to starvation GO:0030334: regulation of cell migration GO:0009725: response to hormone stimulus GO:0022900: electron transport chain GO:0001570: vasculogenesis GO:0031994: insulin-like growth factor I binding GO:0005230: extracellular ligand-gated ion channel activity GO:0007259: JAK-STAT cascade GO:0007194: negative regulation of adenylate cyclase activity GO:0001755: neural crest cell migration GO:0048662: negative regulation of smooth muscle cell proliferation GO:0008289: lipid binding GO:0045449: regulation of transcription GO:0051020: GTPase binding GO:0008219: cell death GO:0030521: androgen receptor signaling pathway GO:0006629: lipid metabolic process GO:0042981: regulation of apoptosis GO:0014912: negative regulation of smooth muscle cell migration GO:0030198: extracellular matrix organization GO:0005506: iron ion binding GO:0030500: regulation of bone mineralization GO:0030162: regulation of proteolysis GO:0007229: integrin-mediated signaling pathway GO:0005057: receptor signaling protein activity GO:0003774: motor activity GO:0004222: metalloendopeptidase activity GO:0007200: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0006796: phosphate metabolic process GO:0008168: methyltransferase activity GO:0006826: iron ion transport GO:0019722: calcium-mediated signaling GO:0006874: cellular calcium ion homeostasis GO:0042391: regulation of membrane potential GO:0005739: mitochondrion GO:0006955: immune response GO:0004551: nucleotide diphosphatase activity GO:0008217: regulation of blood pressure GO:0030528: transcription regulator activity GO:0005158: insulin receptor binding GO:0030308: negative regulation of cell growth GO:0007171: activation of transmembrane receptor protein tyrosine kinase activity GO:0005911: cell-cell junction GO:0010008: endosome membrane GO:0045599: negative regulation of fat cell differentiation GO:0006091: generation of precursor metabolites and energy #1051IR #1063IR #1083IR #10IR 2 GO:0030165: PDZ domain binding GO:0016339: calcium-dependent cell-cell adhesion #1051IR #1063IR #1083IR #1095IR 7 GO:0006917: induction of apoptosis GO:0005875: microtubule associated complex GO:0005891: voltage-gated calcium channel complex GO:0007626: locomotory behavior GO:0004896: cytokine receptor activity GO:0016301: kinase activity GO:0005245: voltage-gated calcium channel activity #1083IR #1095IR #10IR 14 GO:0003712: transcription cofactor activity GO:0008301: DNA bending activity GO:0007015: actin filament organization GO:0017153: sodium:dicarboxylate symporter activity GO:0006835: dicarboxylic acid transport GO:0005070: SH3/SH2 adaptor activity GO:0003777: microtubule motor activity GO:0015813: L-glutamate transport GO:0040007: growth GO:0007126: meiosis GO:0048468: cell development GO:0007286: spermatid development GO:0003785: actin monomer binding GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process #1051IR #1095IR #10IR 24 GO:0046627: negative regulation of insulin receptor signaling pathway GO:0016820: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0014826: vein smooth muscle contraction GO:0003707: steroid hormone receptor activity GO:0006754: ATP biosynthetic process GO:0045719: negative regulation of glycogen biosynthetic process GO:0047429: nucleoside-triphosphate diphosphatase activity GO:0043034: costamere GO:0045722: positive regulation of gluconeogenesis GO:0050427: 3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0009143: nucleoside triphosphate catabolic process GO:0050909: sensory perception of taste GO:0030730: sequestering of triglyceride GO:0001600: endothelin-B receptor activity GO:0009187: cyclic nucleotide metabolic process GO:0006885: regulation of pH GO:0006367: transcription initiation from RNA polymerase II promoter GO:0030643: cellular phosphate ion homeostasis GO:0050681: androgen receptor binding GO:0030374: ligand-dependent nuclear receptor transcription coactivator activity GO:0007187: G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007368: determination of left/right symmetry GO:0016455: RNA polymerase II transcription mediator activity GO:0046325: negative regulation of glucose import #1063IR #1095IR #10IR 304 GO:0048705: skeletal system morphogenesis GO:0043184: vascular endothelial growth factor receptor 2 binding GO:0045787: positive regulation of cell cycle GO:0032587: ruffle membrane GO:0001942: hair follicle development GO:0001540: beta-amyloid binding GO:0005770: late endosome GO:0043536: positive regulation of blood vessel endothelial cell migration GO:0043204: perikaryon GO:0019221: cytokine-mediated signaling pathway GO:0032355: response to estradiol stimulus GO:0005159: insulin-like growth factor receptor binding GO:0051291: protein heterooligomerization GO:0043627: response to estrogen stimulus GO:0042626: ATPase activity, coupled to transmembrane movement of substances GO:0032874: positive regulation of stress-activated MAPK cascade GO:0016032: viral reproduction GO:0000902: cell morphogenesis GO:0046983: protein dimerization activity GO:0008624: induction of apoptosis by extracellular signals GO:0005922: connexon complex GO:0006688: glycosphingolipid biosynthetic process GO:0031902: late endosome membrane GO:0005759: mitochondrial matrix GO:0008236: serine-type peptidase activity GO:0004197: cysteine-type endopeptidase activity GO:0043231: intracellular membrane-bounded organelle GO:0006911: phagocytosis, engulfment GO:0008009: chemokine activity GO:0008415: acyltransferase activity GO:0005778: peroxisomal membrane GO:0006805: xenobiotic metabolic process GO:0005952: cAMP-dependent protein kinase complex GO:0030425: dendrite GO:0043120: tumor necrosis factor binding GO:0006695: cholesterol biosynthetic process GO:0008603: cAMP-dependent protein kinase regulator activity GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein GO:0008147: structural constituent of bone GO:0048741: skeletal muscle fiber development GO:0001937: negative regulation of endothelial cell proliferation GO:0016702: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0007173: epidermal growth factor receptor signaling pathway GO:0015333: peptide:hydrogen symporter activity GO:0043434: response to peptide hormone stimulus GO:0006112: energy reserve metabolic process GO:0050905: neuromuscular process GO:0000776: kinetochore GO:0031557: induction of programmed cell death in response to chemical stimulus GO:0043542: endothelial cell migration GO:0044262: cellular carbohydrate metabolic process GO:0042755: eating behavior GO:0009617: response to bacterium GO:0046330: positive regulation of JNK cascade GO:0001837: epithelial to mesenchymal transition GO:0007435: salivary gland morphogenesis GO:0030307: positive regulation of cell growth GO:0048011: nerve growth factor receptor signaling pathway GO:0006919: activation of caspase activity GO:0001889: liver development GO:0031290: retinal ganglion cell axon guidance GO:0050900: leukocyte migration GO:0004623: phospholipase A2 activity GO:0008017: microtubule binding GO:0001541: ovarian follicle development GO:0006605: protein targeting GO:0001654: eye development GO:0019903: protein phosphatase binding GO:0005768: endosome GO:0043524: negative regulation of neuron apoptosis GO:0004568: chitinase activity GO:0031069: hair follicle morphogenesis GO:0019228: regulation of action potential in neuron GO:0008305: integrin complex GO:0004672: protein kinase activity GO:0008286: insulin receptor signaling pathway GO:0007190: activation of adenylate cyclase activity GO:0007204: elevation of cytosolic calcium ion concentration GO:0005771: multivesicular body GO:0005160: transforming growth factor beta receptor binding GO:0017046: peptide hormone binding GO:0016050: vesicle organization GO:0001968: fibronectin binding GO:0051726: regulation of cell cycle GO:0048168: regulation of neuronal synaptic plasticity GO:0042325: regulation of phosphorylation GO:0015175: neutral amino acid transmembrane transporter activity GO:0005089: Rho guanyl-nucleotide exchange factor activity GO:0005758: mitochondrial intermembrane space GO:0015297: antiporter activity GO:0030900: forebrain development GO:0045892: negative regulation of transcription, DNA-dependent GO:0016504: peptidase activator activity GO:0035094: response to nicotine GO:0016264: gap junction assembly GO:0016500: protein-hormone receptor activity GO:0006935: chemotaxis GO:0042110: T cell activation GO:0043525: positive regulation of neuron apoptosis GO:0006633: fatty acid biosynthetic process GO:0051384: response to glucocorticoid stimulus GO:0006643: membrane lipid metabolic process GO:0003702: RNA polymerase II transcription factor activity GO:0006663: platelet activating factor biosynthetic process GO:0042605: peptide antigen binding GO:0010718: positive regulation of epithelial to mesenchymal transition GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation GO:0004497: monooxygenase activity GO:0045726: positive regulation of integrin biosynthetic process GO:0006220: pyrimidine nucleotide metabolic process GO:0047555: 3',5'-cyclic-GMP phosphodiesterase activity GO:0030170: pyridoxal phosphate binding GO:0031418: L-ascorbic acid binding GO:0006809: nitric oxide biosynthetic process GO:0001502: cartilage condensation GO:0006974: response to DNA damage stimulus GO:0060271: cilium morphogenesis GO:0050778: positive regulation of immune response GO:0019959: interleukin-8 binding GO:0006892: post-Golgi vesicle-mediated transport GO:0031295: T cell costimulation GO:0031966: mitochondrial membrane GO:0010693: negative regulation of alkaline phosphatase activity GO:0019966: interleukin-1 binding GO:0009409: response to cold GO:0050777: negative regulation of immune response GO:0016209: antioxidant activity GO:0042542: response to hydrogen peroxide GO:0060389: pathway-restricted SMAD protein phosphorylation GO:0015334: high affinity oligopeptide transporter activity GO:0051091: positive regulation of transcription factor activity GO:0043169: cation binding GO:0005868: cytoplasmic dynein complex GO:0019216: regulation of lipid metabolic process GO:0007214: gamma-aminobutyric acid signaling pathway GO:0030315: T-tubule GO:0007215: glutamate signaling pathway GO:0030182: neuron differentiation GO:0051891: positive regulation of cardioblast differentiation GO:0000075: cell cycle checkpoint GO:0007283: spermatogenesis GO:0005802: trans-Golgi network GO:0004089: carbonate dehydratase activity GO:0022601: menstrual cycle phase GO:0051018: protein kinase A binding GO:0016829: lyase activity GO:0043531: ADP binding GO:0001938: positive regulation of endothelial cell proliferation GO:0019430: removal of superoxide radicals GO:0048678: response to axon injury GO:0005520: insulin-like growth factor binding GO:0010575: positive regulation vascular endothelial growth factor production GO:0048663: neuron fate commitment GO:0008430: selenium binding GO:0019233: sensory perception of pain GO:0043066: negative regulation of apoptosis GO:0006107: oxaloacetate metabolic process GO:0009615: response to virus GO:0005916: fascia adherens GO:0051258: protein polymerization GO:0006879: cellular iron ion homeostasis GO:0005003: ephrin receptor activity GO:0016798: hydrolase activity, acting on glycosyl bonds GO:0048103: somatic stem cell division GO:0043499: eukaryotic cell surface binding GO:0008146: sulfotransferase activity GO:0007585: respiratory gaseous exchange GO:0016568: chromatin modification GO:0045296: cadherin binding GO:0006032: chitin catabolic process GO:0009636: response to toxin GO:0051402: neuron apoptosis GO:0007623: circadian rhythm GO:0015893: drug transport GO:0005777: peroxisome GO:0009966: regulation of signal transduction GO:0008021: synaptic vesicle GO:0045669: positive regulation of osteoblast differentiation GO:0048172: regulation of short-term neuronal synaptic plasticity GO:0000187: activation of MAPK activity GO:0043195: terminal button GO:0030552: cAMP binding GO:0005925: focal adhesion GO:0005938: cell cortex GO:0004965: GABA-B receptor activity GO:0043027: caspase inhibitor activity GO:0032570: response to progesterone stimulus GO:0031012: extracellular matrix GO:0048545: response to steroid hormone stimulus GO:0005743: mitochondrial inner membrane GO:0051084: 'de novo' posttranslational protein folding GO:0003828: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0050729: positive regulation of inflammatory response GO:0043154: negative regulation of caspase activity GO:0005765: lysosomal membrane GO:0045893: positive regulation of transcription, DNA-dependent GO:0051592: response to calcium ion GO:0006006: glucose metabolic process GO:0045732: positive regulation of protein catabolic process GO:0005381: iron ion transmembrane transporter activity GO:0030097: hemopoiesis GO:0008144: drug binding GO:0019953: sexual reproduction GO:0005114: type II transforming growth factor beta receptor binding GO:0033630: positive regulation of cell adhesion mediated by integrin GO:0004143: diacylglycerol kinase activity GO:0006464: protein modification process GO:0031965: nuclear membrane GO:0016922: ligand-dependent nuclear receptor binding GO:0004046: aminoacylase activity GO:0015467: G-protein activated inward rectifier potassium channel activity GO:0015075: ion transmembrane transporter activity GO:0006469: negative regulation of protein kinase activity GO:0001947: heart looping GO:0008076: voltage-gated potassium channel complex GO:0045454: cell redox homeostasis GO:0010634: positive regulation of epithelial cell migration GO:0005080: protein kinase C binding GO:0034097: response to cytokine stimulus GO:0007010: cytoskeleton organization GO:0000785: chromatin GO:0050680: negative regulation of epithelial cell proliferation GO:0007265: Ras protein signal transduction GO:0001666: response to hypoxia GO:0009395: phospholipid catabolic process GO:0042416: dopamine biosynthetic process GO:0005905: coated pit GO:0070064: proline-rich region binding GO:0009749: response to glucose stimulus GO:0006396: RNA processing GO:0006749: glutathione metabolic process GO:0060317: cardiac epithelial to mesenchymal transition GO:0008028: monocarboxylic acid transmembrane transporter activity GO:0045778: positive regulation of ossification GO:0006096: glycolysis GO:0048666: neuron development GO:0004702: receptor signaling protein serine/threonine kinase activity GO:0008237: metallopeptidase activity GO:0031016: pancreas development GO:0060038: cardiac muscle cell proliferation GO:0048754: branching morphogenesis of a tube GO:0000165: MAPKKK cascade GO:0010038: response to metal ion GO:0050796: regulation of insulin secretion GO:0040014: regulation of multicellular organism growth GO:0030593: neutrophil chemotaxis GO:0048813: dendrite morphogenesis GO:0005198: structural molecule activity GO:0030496: midbody GO:0004177: aminopeptidase activity GO:0043043: peptide biosynthetic process GO:0000079: regulation of cyclin-dependent protein kinase activity GO:0005635: nuclear envelope GO:0032909: regulation of transforming growth factor-beta2 production GO:0006281: DNA repair GO:0060021: palate development GO:0035023: regulation of Rho protein signal transduction GO:0032147: activation of protein kinase activity GO:0015804: neutral amino acid transport GO:0000084: S phase of mitotic cell cycle GO:0042060: wound healing GO:0007154: cell communication GO:0006909: phagocytosis GO:0007050: cell cycle arrest GO:0005741: mitochondrial outer membrane GO:0051219: phosphoprotein binding GO:0005764: lysosome GO:0031901: early endosome membrane GO:0043200: response to amino acid stimulus GO:0050770: regulation of axonogenesis GO:0046320: regulation of fatty acid oxidation GO:0016567: protein ubiquitination GO:0045766: positive regulation of angiogenesis GO:0006366: transcription from RNA polymerase II promoter GO:0048469: cell maturation GO:0008373: sialyltransferase activity GO:0022857: transmembrane transporter activity GO:0008203: cholesterol metabolic process GO:0008509: anion transmembrane transporter activity GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030168: platelet activation GO:0008656: caspase activator activity GO:0044267: cellular protein metabolic process GO:0045471: response to ethanol GO:0009612: response to mechanical stimulus GO:0030100: regulation of endocytosis GO:0016564: transcription repressor activity GO:0007588: excretion GO:0006631: fatty acid metabolic process GO:0045823: positive regulation of heart contraction GO:0007040: lysosome organization GO:0006139: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process GO:0030890: positive regulation of B cell proliferation GO:0008347: glial cell migration GO:0007389: pattern specification process GO:0019825: oxygen binding GO:0000777: condensed chromosome kinetochore GO:0004857: enzyme inhibitor activity GO:0048699: generation of neurons GO:0051795: positive regulation of catagen GO:0042593: glucose homeostasis GO:0000082: G1/S transition of mitotic cell cycle GO:0007205: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0051899: membrane depolarization #1063IR #1083IR #10IR 21 GO:0030672: synaptic vesicle membrane GO:0017157: regulation of exocytosis GO:0005606: laminin-1 complex GO:0042130: negative regulation of T cell proliferation GO:0006898: receptor-mediated endocytosis GO:0005902: microvillus GO:0022891: substrate-specific transmembrane transporter activity GO:0045184: establishment of protein localization GO:0017075: syntaxin-1 binding GO:0005626: insoluble fraction GO:0000786: nucleosome GO:0042393: histone binding GO:0055085: transmembrane transport GO:0048843: negative regulation of axon extension involved in axon guidance GO:0004115: 3',5'-cyclic-AMP phosphodiesterase activity GO:0050679: positive regulation of epithelial cell proliferation GO:0014069: postsynaptic density GO:0007398: ectoderm development GO:0005546: phosphatidylinositol-4,5-bisphosphate binding GO:0043010: camera-type eye development GO:0042383: sarcolemma #1051IR #1063IR #10IR 25 GO:0005319: lipid transporter activity GO:0004889: nicotinic acetylcholine-activated cation-selective channel activity GO:0050821: protein stabilization GO:0008013: beta-catenin binding GO:0006940: regulation of smooth muscle contraction GO:0005892: nicotinic acetylcholine-gated receptor-channel complex GO:0019898: extrinsic to membrane GO:0030178: negative regulation of Wnt receptor signaling pathway GO:0034394: protein localization at cell surface GO:0005178: integrin binding GO:0030863: cortical cytoskeleton GO:0015171: amino acid transmembrane transporter activity GO:0015464: acetylcholine receptor activity GO:0045597: positive regulation of cell differentiation GO:0005912: adherens junction GO:0006865: amino acid transport GO:0006953: acute-phase response GO:0003730: mRNA 3'-UTR binding GO:0030336: negative regulation of cell migration GO:0005581: collagen GO:0060079: regulation of excitatory postsynaptic membrane potential GO:0007611: learning or memory GO:0007005: mitochondrion organization GO:0009312: oligosaccharide biosynthetic process GO:0042157: lipoprotein metabolic process #1051IR #1083IR #1095IR 13 GO:0055114: oxidation reduction GO:0003700: transcription factor activity GO:0005545: phosphatidylinositol binding GO:0006486: protein amino acid glycosylation GO:0007517: muscle development GO:0006468: protein amino acid phosphorylation GO:0007242: intracellular signaling cascade GO:0006350: transcription GO:0006470: protein amino acid dephosphorylation GO:0030955: potassium ion binding GO:0007416: synaptogenesis GO:0019941: modification-dependent protein catabolic process GO:0004653: polypeptide N-acetylgalactosaminyltransferase activity #1063IR #1083IR #1095IR 26 GO:0016327: apicolateral plasma membrane GO:0050860: negative regulation of T cell receptor signaling pathway GO:0006690: icosanoid metabolic process GO:0005042: netrin receptor activity GO:0006310: DNA recombination GO:0051233: spindle midzone GO:0008585: female gonad development GO:0005100: Rho GTPase activator activity GO:0001890: placenta development GO:0009566: fertilization GO:0001756: somitogenesis GO:0005095: GTPase inhibitor activity GO:0006914: autophagy GO:0018298: protein-chromophore linkage GO:0007269: neurotransmitter secretion GO:0005884: actin filament GO:0003950: NAD+ ADP-ribosyltransferase activity GO:0008218: bioluminescence GO:0019896: axon transport of mitochondrion GO:0042813: Wnt receptor activity GO:0030509: BMP signaling pathway GO:0019079: viral genome replication GO:0050885: neuromuscular process controlling balance GO:0009311: oligosaccharide metabolic process GO:0001504: neurotransmitter uptake GO:0043205: fibril #1051IR #1063IR #1095IR 28 GO:0007219: Notch signaling pathway GO:0001775: cell activation GO:0016310: phosphorylation GO:0043569: negative regulation of insulin-like growth factor receptor signaling pathway GO:0018108: peptidyl-tyrosine phosphorylation GO:0008499: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity GO:0017166: vinculin binding GO:0006559: L-phenylalanine catabolic process GO:0045028: purinergic nucleotide receptor activity, G-protein coupled GO:0045165: cell fate commitment GO:0007271: synaptic transmission, cholinergic GO:0005793: ER-Golgi intermediate compartment GO:0048407: platelet-derived growth factor binding GO:0030318: melanocyte differentiation GO:0001542: ovulation from ovarian follicle GO:0005249: voltage-gated potassium channel activity GO:0007422: peripheral nervous system development GO:0000155: two-component sensor activity GO:0045740: positive regulation of DNA replication GO:0008360: regulation of cell shape GO:0005179: hormone activity GO:0005018: platelet-derived growth factor alpha-receptor activity GO:0017148: negative regulation of translation GO:0004890: GABA-A receptor activity GO:0048146: positive regulation of fibroblast proliferation GO:0005328: neurotransmitter:sodium symporter activity GO:0006572: tyrosine catabolic process GO:0015269: calcium-activated potassium channel activity #1095IR #10IR 137 GO:0031227: intrinsic to endoplasmic reticulum membrane GO:0006656: phosphatidylcholine biosynthetic process GO:0015078: hydrogen ion transmembrane transporter activity GO:0048538: thymus development GO:0045860: positive regulation of protein kinase activity GO:0006108: malate metabolic process GO:0030330: DNA damage response, signal transduction by p53 class mediator GO:0004540: ribonuclease activity GO:0006094: gluconeogenesis GO:0019001: guanyl nucleotide binding GO:0009650: UV protection GO:0005388: calcium-transporting ATPase activity GO:0007252: I-kappaB phosphorylation GO:0004004: ATP-dependent RNA helicase activity GO:0007188: G-protein signaling, coupled to cAMP nucleotide second messenger GO:0032963: collagen metabolic process GO:0004386: helicase activity GO:0030101: natural killer cell activation GO:0045859: regulation of protein kinase activity GO:0030176: integral to endoplasmic reticulum membrane GO:0004322: ferroxidase activity GO:0042612: MHC class I protein complex GO:0019439: aromatic compound catabolic process GO:0030553: cGMP binding GO:0006222: UMP biosynthetic process GO:0004364: glutathione transferase activity GO:0016070: RNA metabolic process GO:0002474: antigen processing and presentation of peptide antigen via MHC class I GO:0005834: heterotrimeric G-protein complex GO:0008544: epidermis development GO:0015992: proton transport GO:0008320: protein transmembrane transporter activity GO:0000186: activation of MAPKK activity GO:0005097: Rab GTPase activator activity GO:0042645: mitochondrial nucleoid GO:0032313: regulation of Rab GTPase activity GO:0016461: unconventional myosin complex GO:0030867: rough endoplasmic reticulum membrane GO:0005391: sodium:potassium-exchanging ATPase activity GO:0005641: nuclear envelope lumen GO:0006164: purine nucleotide biosynthetic process GO:0048873: homeostasis of number of cells within a tissue GO:0001935: endothelial cell proliferation GO:0030216: keratinocyte differentiation GO:0045088: regulation of innate immune response GO:0000502: proteasome complex GO:0006509: membrane protein ectodomain proteolysis GO:0031941: filamentous actin GO:0000303: response to superoxide GO:0004104: cholinesterase activity GO:0043457: regulation of cellular respiration GO:0007565: female pregnancy GO:0016779: nucleotidyltransferase activity GO:0019861: flagellum GO:0031424: keratinization GO:0060001: minus-end directed microfilament motor activity GO:0007405: neuroblast proliferation GO:0051216: cartilage development GO:0006210: thymine catabolic process GO:0015701: bicarbonate transport GO:0006212: uracil catabolic process GO:0006825: copper ion transport GO:0014850: response to muscle activity GO:0015718: monocarboxylic acid transport GO:0004180: carboxypeptidase activity GO:0005452: inorganic anion exchanger activity GO:0048477: oogenesis GO:0014003: oligodendrocyte development GO:0043085: positive regulation of catalytic activity GO:0046920: alpha(1,3)-fucosyltransferase activity GO:0005247: voltage-gated chloride channel activity GO:0006986: response to unfolded protein GO:0019370: leukotriene biosynthetic process GO:0006214: thymidine catabolic process GO:0042254: ribosome biogenesis GO:0031638: zymogen activation GO:0045334: clathrin-coated endocytic vesicle GO:0016881: acid-amino acid ligase activity GO:0006417: regulation of translation GO:0005788: endoplasmic reticulum lumen GO:0010181: FMN binding GO:0006821: chloride transport GO:0004385: guanylate kinase activity GO:0016747: transferase activity, transferring acyl groups other than amino-acyl groups GO:0046870: cadmium ion binding GO:0008199: ferric iron binding GO:0016493: C-C chemokine receptor activity GO:0005504: fatty acid binding GO:0051539: 4 iron, 4 sulfur cluster binding GO:0005929: cilium GO:0004181: metallocarboxypeptidase activity GO:0032722: positive regulation of chemokine production GO:0006635: fatty acid beta-oxidation GO:0051046: regulation of secretion GO:0060087: relaxation of vascular smooth muscle GO:0046688: response to copper ion GO:0043588: skin development GO:0046873: metal ion transmembrane transporter activity GO:0008026: ATP-dependent helicase activity GO:0007341: penetration of zona pellucida GO:0032393: MHC class I receptor activity GO:0004866: endopeptidase inhibitor activity GO:0006207: 'de novo' pyrimidine base biosynthetic process GO:0009607: response to biotic stimulus GO:0006145: purine base catabolic process GO:0060173: limb development GO:0007254: JNK cascade GO:0019695: choline metabolic process GO:0006875: cellular metal ion homeostasis GO:0007612: learning GO:0042355: L-fucose catabolic process GO:0004693: cyclin-dependent protein kinase activity GO:0006099: tricarboxylic acid cycle GO:0030048: actin filament-based movement GO:0030520: estrogen receptor signaling pathway GO:0016591: DNA-directed RNA polymerase II, holoenzyme GO:0017113: dihydropyrimidine dehydrogenase (NADP+) activity GO:0007598: blood coagulation, extrinsic pathway GO:0045919: positive regulation of cytolysis GO:0050783: cocaine metabolic process GO:0006880: intracellular sequestering of iron ion GO:0002526: acute inflammatory response GO:0035035: histone acetyltransferase binding GO:0000302: response to reactive oxygen species GO:0051607: defense response to virus GO:0004185: serine-type carboxypeptidase activity GO:0005375: copper ion transmembrane transporter activity GO:0042102: positive regulation of T cell proliferation GO:0015501: glutamate:sodium symporter activity GO:0001533: cornified envelope GO:0006541: glutamine metabolic process GO:0008510: sodium:bicarbonate symporter activity GO:0003945: N-acetyllactosamine synthase activity GO:0019882: antigen processing and presentation GO:0008043: intracellular ferritin complex GO:0006783: heme biosynthetic process GO:0004158: dihydroorotate oxidase activity #1083IR #10IR 21 GO:0030957: Tat protein binding GO:0032420: stereocilium GO:0016595: glutamate binding GO:0030274: LIM domain binding GO:0016524: latrotoxin receptor activity GO:0016316: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity GO:0042742: defense response to bacterium GO:0045109: intermediate filament organization GO:0005903: brush border GO:0015180: L-alanine transmembrane transporter activity GO:0048808: male genitalia morphogenesis GO:0005871: kinesin complex GO:0050890: cognition GO:0032279: asymmetric synapse GO:0042113: B cell activation GO:0015808: L-alanine transport GO:0005212: structural constituent of eye lens GO:0008093: cytoskeletal adaptor activity GO:0032387: negative regulation of intracellular transport GO:0005314: high-affinity glutamate transmembrane transporter activity GO:0005876: spindle microtubule #1051IR #10IR 15 GO:0008527: taste receptor activity GO:0001678: cellular glucose homeostasis GO:0035066: positive regulation of histone acetylation GO:0046321: positive regulation of fatty acid oxidation GO:0045333: cellular respiration GO:0050873: brown fat cell differentiation GO:0005665: DNA-directed RNA polymerase II, core complex GO:0001659: temperature homeostasis GO:0005001: transmembrane receptor protein tyrosine phosphatase activity GO:0022904: respiratory electron transport chain GO:0004114: 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0045295: gamma-catenin binding GO:0004949: cannabinoid receptor activity GO:0007610: behavior GO:0018149: peptide cross-linking #1063IR #10IR 506 GO:0048812: neuron projection morphogenesis GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0010759: positive regulation of macrophage chemotaxis GO:0060070: canonical Wnt receptor signaling pathway GO:0032094: response to food GO:0030247: polysaccharide binding GO:0018279: protein N-linked glycosylation via asparagine GO:0019807: aspartoacylase activity GO:0006939: smooth muscle contraction GO:0008398: sterol 14-demethylase activity GO:0019432: triglyceride biosynthetic process GO:0070195: growth hormone receptor complex GO:0004903: growth hormone receptor activity GO:0002634: regulation of germinal center formation GO:0006928: cellular component movement GO:0006906: vesicle fusion GO:0060325: face morphogenesis GO:0048539: bone marrow development GO:0006325: chromatin organization GO:0017016: Ras GTPase binding GO:0035307: positive regulation of protein dephosphorylation GO:0046449: creatinine metabolic process GO:0008198: ferrous iron binding GO:0043101: purine-containing compound salvage GO:0042578: phosphoric ester hydrolase activity GO:0010553: negative regulation of gene-specific transcription from RNA polymerase II promoter GO:0071062: alphav-beta3 integrin-vitronectin complex GO:0005980: glycogen catabolic process GO:0046581: intercellular canaliculus GO:0007568: aging GO:0004833: tryptophan 2,3-dioxygenase activity GO:0001656: metanephros development GO:0021506: anterior neuropore closure GO:0050479: glyceryl-ether monooxygenase activity GO:0006569: tryptophan catabolic process GO:0050998: nitric-oxide synthase binding GO:0048514: blood vessel morphogenesis GO:0007517: muscle organ development GO:0050768: negative regulation of neurogenesis GO:0005901: caveola GO:0022409: positive regulation of cell-cell adhesion GO:0070836: caveola assembly GO:0002051: osteoblast fate commitment GO:0043966: histone H3 acetylation GO:0030177: positive regulation of Wnt receptor signaling pathway GO:0043403: skeletal muscle tissue regeneration GO:0070172: positive regulation of tooth mineralization GO:0002709: regulation of T cell mediated immunity GO:0002020: protease binding GO:0017154: semaphorin receptor activity GO:0010843: promoter binding GO:0004459: L-lactate dehydrogenase activity GO:0021766: hippocampus development GO:0004445: inositol-polyphosphate 5-phosphatase activity GO:0080025: phosphatidylinositol-3,5-bisphosphate binding GO:0006776: vitamin A metabolic process GO:0010596: negative regulation of endothelial cell migration GO:0044236: multicellular organismal metabolic process GO:0001676: long-chain fatty acid metabolic process GO:0010951: negative regulation of endopeptidase activity GO:0030147: natriuresis GO:0045879: negative regulation of smoothened signaling pathway GO:0042936: dipeptide transporter activity GO:0045329: carnitine biosynthetic process GO:0034755: iron ion transmembrane transport GO:0004000: adenosine deaminase activity GO:0010936: negative regulation of macrophage cytokine production GO:0051591: response to cAMP GO:0014049: positive regulation of glutamate secretion GO:0004435: phosphatidylinositol phospholipase C activity GO:0005773: vacuole GO:0048312: intracellular distribution of mitochondria GO:0007274: neuromuscular synaptic transmission GO:0009168: purine ribonucleoside monophosphate biosynthetic process GO:0030902: hindbrain development GO:0050748: negative regulation of lipoprotein metabolic process GO:0090090: negative regulation of canonical Wnt receptor signaling pathway GO:0006351: transcription, DNA-dependent GO:0007044: cell-substrate junction assembly GO:0030133: transport vesicle GO:0000216: M/G1 transition of mitotic cell cycle GO:0032809: neuronal cell body membrane GO:0004336: galactosylceramidase activity GO:0070050: neuron homeostasis GO:0071320: cellular response to cAMP GO:0045124: regulation of bone resorption GO:0010524: positive regulation of calcium ion transport into cytosol GO:0006105: succinate metabolic process GO:0043235: receptor complex GO:0043278: response to morphine GO:0006767: water-soluble vitamin metabolic process GO:0043097: pyrimidine nucleoside salvage GO:0033300: dehydroascorbic acid transporter activity GO:0021879: forebrain neuron differentiation GO:0032496: response to lipopolysaccharide GO:0016010: dystrophin-associated glycoprotein complex GO:0005262: calcium channel activity GO:0015267: channel activity GO:0090023: positive regulation of neutrophil chemotaxis GO:0030818: negative regulation of cAMP biosynthetic process GO:0070555: response to interleukin-1 GO:0003700: sequence-specific DNA binding transcription factor activity GO:0002090: regulation of receptor internalization GO:0051789: response to protein stimulus GO:0048661: positive regulation of smooth muscle cell proliferation GO:0032868: response to insulin stimulus GO:0046638: positive regulation of alpha-beta T cell differentiation GO:0050728: negative regulation of inflammatory response GO:0002021: response to dietary excess GO:0043679: axon terminus GO:0034138: toll-like receptor 3 signaling pathway GO:0060484: lung-associated mesenchyme development GO:0019442: tryptophan catabolic process to acetyl-CoA GO:0005154: epidermal growth factor receptor binding GO:0030667: secretory granule membrane GO:0031234: extrinsic to internal side of plasma membrane GO:0006066: alcohol metabolic process GO:0001934: positive regulation of protein phosphorylation GO:0006521: regulation of cellular amino acid metabolic process GO:0031995: insulin-like growth factor II binding GO:0006520: cellular amino acid metabolic process GO:0009166: nucleotide catabolic process GO:0032369: negative regulation of lipid transport GO:0051545: negative regulation of elastin biosynthetic process GO:0033555: multicellular organismal response to stress GO:0032026: response to magnesium ion GO:0010888: negative regulation of lipid storage GO:0055056: D-glucose transmembrane transporter activity GO:0016566: specific transcriptional repressor activity GO:0004943: C3a anaphylatoxin receptor activity GO:0000904: cell morphogenesis involved in differentiation GO:0007266: Rho protein signal transduction GO:0001958: endochondral ossification GO:0046545: development of primary female sexual characteristics GO:0016525: negative regulation of angiogenesis GO:0042166: acetylcholine binding GO:0043394: proteoglycan binding GO:0045596: negative regulation of cell differentiation GO:0005044: scavenger receptor activity GO:0048167: regulation of synaptic plasticity GO:0032755: positive regulation of interleukin-6 production GO:0055037: recycling endosome GO:0048487: beta-tubulin binding GO:0043526: neuroprotection GO:0090082: positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway GO:0070491: repressing transcription factor binding GO:0005088: Ras guanyl-nucleotide exchange factor activity GO:0034372: very-low-density lipoprotein particle remodeling GO:0008645: hexose transport GO:0031258: lamellipodium membrane GO:0032526: response to retinoic acid GO:0051289: protein homotetramerization GO:0048786: presynaptic active zone GO:0034976: response to endoplasmic reticulum stress GO:0042923: neuropeptide binding GO:0043409: negative regulation of MAPKKK cascade GO:0033391: chromatoid body GO:0034599: cellular response to oxidative stress GO:0015250: water channel activity GO:0030901: midbrain development GO:0006090: pyruvate metabolic process GO:0060732: positive regulation of inositol phosphate biosynthetic process GO:0004876: complement component C3a receptor activity GO:0050918: positive chemotaxis GO:0071377: cellular response to glucagon stimulus GO:0031340: positive regulation of vesicle fusion GO:0044130: negative regulation of growth of symbiont in host GO:0051149: positive regulation of muscle cell differentiation GO:0006184: GTP catabolic process GO:0008336: gamma-butyrobetaine dioxygenase activity GO:0007416: synapse assembly GO:0006766: vitamin metabolic process GO:0032983: kainate selective glutamate receptor complex GO:0048630: skeletal muscle tissue growth GO:0007492: endoderm development GO:0055086: nucleobase, nucleoside and nucleotide metabolic process GO:0002430: complement receptor mediated signaling pathway GO:0001850: complement component C3a binding GO:0042692: muscle cell differentiation GO:0051897: positive regulation of protein kinase B signaling cascade GO:0032870: cellular response to hormone stimulus GO:0014842: regulation of satellite cell proliferation GO:0006644: phospholipid metabolic process GO:0010002: cardioblast differentiation GO:0015732: prostaglandin transport GO:0001664: G-protein-coupled receptor binding GO:0003680: AT DNA binding GO:0042568: insulin-like growth factor binary complex GO:0006101: citrate metabolic process GO:0016043: cellular component organization GO:0051259: protein oligomerization GO:0016311: dephosphorylation GO:0031781: type 3 melanocortin receptor binding GO:0051403: stress-activated MAPK cascade GO:0060055: angiogenesis involved in wound healing GO:0046898: response to cycloheximide GO:0048278: vesicle docking GO:0045332: phospholipid translocation GO:0050714: positive regulation of protein secretion GO:0030819: positive regulation of cAMP biosynthetic process GO:0030301: cholesterol transport GO:0005502: 11-cis retinal binding GO:0048755: branching morphogenesis of a nerve GO:0006103: 2-oxoglutarate metabolic process GO:0006533: aspartate catabolic process GO:0006573: valine metabolic process GO:0014824: artery smooth muscle contraction GO:0001869: negative regulation of complement activation, lectin pathway GO:0034186: apolipoprotein A-I binding GO:0004806: triglyceride lipase activity GO:0015186: L-glutamine transmembrane transporter activity GO:0051234: establishment of localization GO:0045542: positive regulation of cholesterol biosynthetic process GO:0006730: one-carbon metabolic process GO:0004850: uridine phosphorylase activity GO:0060161: positive regulation of dopamine receptor signaling pathway GO:0030855: epithelial cell differentiation GO:0090050: positive regulation of cell migration involved in sprouting angiogenesis GO:0035583: negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta GO:0004620: phospholipase activity GO:0050776: regulation of immune response GO:0034329: cell junction assembly GO:0007613: memory GO:0051593: response to folic acid GO:0015101: organic cation transmembrane transporter activity GO:0016044: cellular membrane organization GO:0050660: flavin adenine dinucleotide binding GO:0008081: phosphoric diester hydrolase activity GO:0045715: negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0060463: lung lobe morphogenesis GO:0042136: neurotransmitter biosynthetic process GO:0032760: positive regulation of tumor necrosis factor production GO:0030073: insulin secretion GO:0015132: prostaglandin transmembrane transporter activity GO:0006853: carnitine shuttle GO:0048566: embryonic digestive tract development GO:0046485: ether lipid metabolic process GO:0050804: regulation of synaptic transmission GO:0015035: protein disulfide oxidoreductase activity GO:0031333: negative regulation of protein complex assembly GO:0005614: interstitial matrix GO:0060337: type I interferon-mediated signaling pathway GO:0008643: carbohydrate transport GO:0048839: inner ear development GO:0005545: 1-phosphatidylinositol binding GO:0008543: fibroblast growth factor receptor signaling pathway GO:0060346: bone trabecula formation GO:0031224: intrinsic to membrane GO:0060396: growth hormone receptor signaling pathway GO:0055114: oxidation-reduction process GO:0001933: negative regulation of protein phosphorylation GO:0007088: regulation of mitosis GO:0002092: positive regulation of receptor internalization GO:0050891: multicellular organismal water homeostasis GO:0043014: alpha-tubulin binding GO:0042567: insulin-like growth factor ternary complex GO:0001569: patterning of blood vessels GO:0016597: amino acid binding GO:0090303: positive regulation of wound healing GO:0006486: protein glycosylation GO:0010552: positive regulation of gene-specific transcription from RNA polymerase II promoter GO:0035115: embryonic forelimb morphogenesis GO:0009755: hormone-mediated signaling pathway GO:0006069: ethanol oxidation GO:0003987: acetate-CoA ligase activity GO:0002040: sprouting angiogenesis GO:0033267: axon part GO:0042637: catagen GO:0042895: antibiotic transporter activity GO:0035116: embryonic hindlimb morphogenesis GO:0007193: inhibition of adenylate cyclase activity by G-protein signaling pathway GO:0001527: microfibril GO:0030673: axolemma GO:0051482: elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger GO:0060174: limb bud formation GO:0009117: nucleotide metabolic process GO:0046135: pyrimidine nucleoside catabolic process GO:0046427: positive regulation of JAK-STAT cascade GO:0007512: adult heart development GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0047498: calcium-dependent phospholipase A2 activity GO:0031398: positive regulation of protein ubiquitination GO:0060445: branching involved in salivary gland morphogenesis GO:0046426: negative regulation of JAK-STAT cascade GO:0045671: negative regulation of osteoclast differentiation GO:0051781: positive regulation of cell division GO:0035313: wound healing, spreading of epidermal cells GO:0032582: negative regulation of gene-specific transcription GO:0046209: nitric oxide metabolic process GO:0005791: rough endoplasmic reticulum GO:0070935: 3'-UTR-mediated mRNA stabilization GO:0019841: retinol binding GO:0008202: steroid metabolic process GO:0009952: anterior/posterior pattern formation GO:0006468: protein phosphorylation GO:0034220: ion transmembrane transport GO:0001701: in utero embryonic development GO:0031115: negative regulation of microtubule polymerization GO:0008063: Toll signaling pathway GO:0014070: response to organic cyclic compound GO:0031782: type 4 melanocortin receptor binding GO:0051205: protein insertion into membrane GO:0010243: response to organic nitrogen GO:0000209: protein polyubiquitination GO:0005921: gap junction GO:0016079: synaptic vesicle exocytosis GO:0045885: positive regulation of survival gene product expression GO:0005242: inward rectifier potassium channel activity GO:0030278: regulation of ossification GO:0034707: chloride channel complex GO:0019433: triglyceride catabolic process GO:0043084: penile erection GO:0050830: defense response to Gram-positive bacterium GO:0008528: peptide receptor activity, G-protein coupled GO:0055065: metal ion homeostasis GO:0010037: response to carbon dioxide GO:0070588: calcium ion transmembrane transport GO:0007597: blood coagulation, intrinsic pathway GO:0070837: dehydroascorbic acid transport GO:0004999: vasoactive intestinal polypeptide receptor activity GO:0034134: toll-like receptor 2 signaling pathway GO:0002686: negative regulation of leukocyte migration GO:0046855: inositol phosphate dephosphorylation GO:0043691: reverse cholesterol transport GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis GO:0001944: vasculature development GO:0002224: toll-like receptor signaling pathway GO:0008160: protein tyrosine phosphatase activator activity GO:0034332: adherens junction organization GO:0015030: Cajal body GO:0048706: embryonic skeletal system development GO:0030665: clathrin coated vesicle membrane GO:0009268: response to pH GO:0016941: natriuretic peptide receptor activity GO:0004383: guanylate cyclase activity GO:0006600: creatine metabolic process GO:0033137: negative regulation of peptidyl-serine phosphorylation GO:0031315: extrinsic to mitochondrial outer membrane GO:0006154: adenosine catabolic process GO:0006921: cellular component disassembly involved in apoptosis GO:0004029: aldehyde dehydrogenase (NAD) activity GO:0045765: regulation of angiogenesis GO:0009790: embryo development GO:0034142: toll-like receptor 4 signaling pathway GO:0070256: negative regulation of mucus secretion GO:0090263: positive regulation of canonical Wnt receptor signaling pathway GO:0031783: type 5 melanocortin receptor binding GO:0010842: retina layer formation GO:0017091: AU-rich element binding GO:0030514: negative regulation of BMP signaling pathway GO:0006527: arginine catabolic process GO:0000255: allantoin metabolic process GO:0010745: negative regulation of macrophage derived foam cell differentiation GO:0016529: sarcoplasmic reticulum GO:0042220: response to cocaine GO:0070365: hepatocyte differentiation GO:0016328: lateral plasma membrane GO:0034375: high-density lipoprotein particle remodeling GO:0046847: filopodium assembly GO:0005372: water transmembrane transporter activity GO:0060666: dichotomous subdivision of terminal units involved in salivary gland branching GO:0050678: regulation of epithelial cell proliferation GO:0051549: positive regulation of keratinocyte migration GO:0042977: activation of JAK2 kinase activity GO:0045663: positive regulation of myoblast differentiation GO:0033144: negative regulation of steroid hormone receptor signaling pathway GO:0051924: regulation of calcium ion transport GO:0005881: cytoplasmic microtubule GO:0006182: cGMP biosynthetic process GO:0007184: SMAD protein import into nucleus GO:0051928: positive regulation of calcium ion transport GO:0035050: embryonic heart tube development GO:0002576: platelet degranulation GO:0048701: embryonic cranial skeleton morphogenesis GO:0004030: aldehyde dehydrogenase [NAD(P)+] activity GO:0048014: Tie receptor signaling pathway GO:0019534: toxin transporter activity GO:0045844: positive regulation of striated muscle tissue development GO:0006206: pyrimidine base metabolic process GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0002070: epithelial cell maturation GO:0005083: small GTPase regulator activity GO:0055091: phospholipid homeostasis GO:0015867: ATP transport GO:0014032: neural crest cell development GO:0031748: D1 dopamine receptor binding GO:0032580: Golgi cisterna membrane GO:0015758: glucose transport GO:0070207: protein homotrimerization GO:0032332: positive regulation of chondrocyte differentiation GO:0019441: tryptophan catabolic process to kynurenine GO:0030850: prostate gland development GO:0042487: regulation of odontogenesis of dentine-containing tooth GO:0030136: clathrin-coated vesicle GO:0003333: amino acid transmembrane transport GO:0007168: receptor guanylyl cyclase signaling pathway GO:0070742: C2H2 zinc finger domain binding GO:0060916: mesenchymal cell proliferation involved in lung development GO:0008179: adenylate cyclase binding GO:0007029: endoplasmic reticulum organization GO:0031622: positive regulation of fever generation GO:0019530: taurine metabolic process GO:0060548: negative regulation of cell death GO:0014909: smooth muscle cell migration GO:0060351: cartilage development involved in endochondral bone morphogenesis GO:0033632: regulation of cell-cell adhesion mediated by integrin GO:0030414: peptidase inhibitor activity GO:0034641: cellular nitrogen compound metabolic process GO:0010232: vascular transport GO:0000922: spindle pole GO:0060348: bone development GO:0001599: endothelin-A receptor activity GO:0035295: tube development GO:0046108: uridine metabolic process GO:0002053: positive regulation of mesenchymal cell proliferation GO:0070295: renal water absorption GO:0019905: syntaxin binding GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0007166: cell surface receptor linked signaling pathway GO:0001649: osteoblast differentiation GO:0070083: clathrin sculpted monoamine transport vesicle membrane GO:0048557: embryonic digestive tract morphogenesis GO:0031960: response to corticosteroid stimulus GO:0060416: response to growth hormone stimulus GO:0040036: regulation of fibroblast growth factor receptor signaling pathway GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0030141: stored secretory granule GO:0007162: negative regulation of cell adhesion GO:0001883: purine nucleoside binding GO:0006144: purine base metabolic process GO:0055093: response to hyperoxia GO:0030057: desmosome GO:0046716: muscle cell homeostasis GO:0010629: negative regulation of gene expression GO:0031625: ubiquitin protein ligase binding GO:0043237: laminin-1 binding GO:0071438: invadopodium membrane GO:0050750: low-density lipoprotein particle receptor binding GO:0048568: embryonic organ development GO:0010595: positive regulation of endothelial cell migration GO:0005184: neuropeptide hormone activity GO:0071398: cellular response to fatty acid GO:0034199: activation of protein kinase A activity GO:0010466: negative regulation of peptidase activity GO:0006833: water transport GO:0010628: positive regulation of gene expression GO:0042277: peptide binding GO:0010811: positive regulation of cell-substrate adhesion GO:0010716: negative regulation of extracellular matrix disassembly GO:0006549: isoleucine metabolic process GO:0033574: response to testosterone stimulus GO:0015695: organic cation transport GO:0001657: ureteric bud development GO:0033089: positive regulation of T cell differentiation in thymus GO:0044255: cellular lipid metabolic process GO:0007202: activation of phospholipase C activity GO:0030210: heparin biosynthetic process GO:0031594: neuromuscular junction GO:0040018: positive regulation of multicellular organism growth GO:0030325: adrenal gland development GO:0004439: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0003007: heart morphogenesis GO:0042787: protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0060333: interferon-gamma-mediated signaling pathway GO:0030501: positive regulation of bone mineralization GO:0046856: phosphatidylinositol dephosphorylation GO:0034704: calcium channel complex GO:0005811: lipid particle GO:0019800: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan GO:0019933: cAMP-mediated signaling GO:0035556: intracellular signal transduction GO:0009954: proximal/distal pattern formation GO:0005539: glycosaminoglycan binding GO:0004175: endopeptidase activity GO:0050881: musculoskeletal movement GO:0002063: chondrocyte development GO:0031092: platelet alpha granule membrane GO:0048019: receptor antagonist activity GO:0017137: Rab GTPase binding GO:0043190: ATP-binding cassette (ABC) transporter complex GO:0043116: negative regulation of vascular permeability GO:0004465: lipoprotein lipase activity GO:0045216: cell-cell junction organization GO:0031175: neuron projection development GO:0071346: cellular response to interferon-gamma GO:0042562: hormone binding GO:0003705: sequence-specific enhancer binding RNA polymerase II transcription factor activity GO:0048870: cell motility GO:0060523: prostate epithelial cord elongation GO:0031780: adrenocorticotropin hormone receptor binding GO:0006683: galactosylceramide catabolic process GO:0005243: gap junction channel activity GO:0090244: Wnt receptor signaling pathway involved in somitogenesis GO:0005355: glucose transmembrane transporter activity GO:0070996: type 1 melanocortin receptor binding GO:0004962: endothelin receptor activity GO:0034130: toll-like receptor 1 signaling pathway GO:0048009: insulin-like growth factor receptor signaling pathway GO:0051281: positive regulation of release of sequestered calcium ion into cytosol GO:0042523: positive regulation of tyrosine phosphorylation of Stat5 protein GO:0050955: thermoception GO:0006012: galactose metabolic process GO:0043025: neuronal cell body GO:0051602: response to electrical stimulus GO:0043252: sodium-independent organic anion transport #1083IR #1095IR 49 GO:0006959: humoral immune response GO:0021965: spinal cord ventral commissure morphogenesis GO:0005840: ribosome GO:0006414: translational elongation GO:0030071: regulation of mitotic metaphase/anaphase transition GO:0045843: negative regulation of striated muscle development GO:0042255: ribosome assembly GO:0032281: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex GO:0003705: RNA polymerase II transcription factor activity, enhancer binding GO:0006228: UTP biosynthetic process GO:0070330: aromatase activity GO:0004065: arylsulfatase activity GO:0043025: cell soma GO:0007093: mitotic cell cycle checkpoint GO:0004550: nucleoside diphosphate kinase activity GO:0043198: dendritic shaft GO:0030141: secretory granule GO:0031014: troponin T binding GO:0000090: mitotic anaphase GO:0006493: protein amino acid O-linked glycosylation GO:0007051: spindle organization GO:0045494: photoreceptor cell maintenance GO:0006183: GTP biosynthetic process GO:0003735: structural constituent of ribosome GO:0051017: actin filament bundle formation GO:0030833: regulation of actin filament polymerization GO:0051246: regulation of protein metabolic process GO:0007163: establishment or maintenance of cell polarity GO:0006928: cell motion GO:0019843: rRNA binding GO:0007569: cell aging GO:0008089: anterograde axon cargo transport GO:0045095: keratin filament GO:0005680: anaphase-promoting complex GO:0051437: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0001919: regulation of receptor recycling GO:0051436: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0048341: paraxial mesoderm formation GO:0005681: spliceosome GO:0005861: troponin complex GO:0006241: CTP biosynthetic process GO:0021542: dentate gyrus development GO:0009416: response to light stimulus GO:0001891: phagocytic cup GO:0051059: NF-kappaB binding GO:0022627: cytosolic small ribosomal subunit GO:0031175: neurite development GO:0006364: rRNA processing GO:0048015: phosphoinositide-mediated signaling #1051IR #1095IR 30 GO:0048154: S100 beta binding GO:0008109: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity GO:0042801: polo kinase kinase activity GO:0006944: membrane fusion GO:0008037: cell recognition GO:0050660: FAD binding GO:0034614: cellular response to reactive oxygen species GO:0034644: cellular response to UV GO:0007338: single fertilization GO:0006497: protein amino acid lipidation GO:0048066: pigmentation during development GO:0031402: sodium ion binding GO:0006957: complement activation, alternative pathway GO:0007497: posterior midgut development GO:0030594: neurotransmitter receptor activity GO:0030286: dynein complex GO:0042953: lipoprotein transport GO:0015662: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0031953: negative regulation of protein amino acid autophosphorylation GO:0046777: protein amino acid autophosphorylation GO:0005005: transmembrane-ephrin receptor activity GO:0000775: chromosome, centromeric region GO:0031404: chloride ion binding GO:0030866: cortical actin cytoskeleton organization GO:0001816: cytokine production GO:0042598: vesicular fraction GO:0007166: cell surface receptor linked signal transduction GO:0004864: phosphoprotein phosphatase inhibitor activity GO:0004411: homogentisate 1,2-dioxygenase activity GO:0006024: glycosaminoglycan biosynthetic process #1063IR #1095IR 179 GO:0007089: traversing start control point of mitotic cell cycle GO:0003697: single-stranded DNA binding GO:0048245: eosinophil chemotaxis GO:0010033: response to organic substance GO:0019900: kinase binding GO:0009987: cellular process GO:0005796: Golgi lumen GO:0070309: lens fiber cell morphogenesis GO:0003690: double-stranded DNA binding GO:0004860: protein kinase inhibitor activity GO:0008242: omega peptidase activity GO:0021952: central nervous system projection neuron axonogenesis GO:0014059: regulation of dopamine secretion GO:0007176: regulation of epidermal growth factor receptor activity GO:0017147: Wnt-protein binding GO:0008584: male gonad development GO:0048845: venous blood vessel morphogenesis GO:0050662: coenzyme binding GO:0008467: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity GO:0051537: 2 iron, 2 sulfur cluster binding GO:0045182: translation regulator activity GO:0043130: ubiquitin binding GO:0021680: cerebellar Purkinje cell layer development GO:0035162: embryonic hemopoiesis GO:0050659: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity GO:0008195: phosphatidate phosphatase activity GO:0007566: embryo implantation GO:0021987: cerebral cortex development GO:0019915: lipid storage GO:0004879: ligand-dependent nuclear receptor activity GO:0001508: regulation of action potential GO:0032839: dendrite cytoplasm GO:0042246: tissue regeneration GO:0042989: sequestering of actin monomers GO:0030968: endoplasmic reticulum unfolded protein response GO:0008234: cysteine-type peptidase activity GO:0005740: mitochondrial envelope GO:0007595: lactation GO:0015914: phospholipid transport GO:0060298: positive regulation of sarcomere organization GO:0000718: nucleotide-excision repair, DNA damage removal GO:0048037: cofactor binding GO:0045737: positive regulation of cyclin-dependent protein kinase activity GO:0009313: oligosaccharide catabolic process GO:0050699: WW domain binding GO:0009306: protein secretion GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0001974: blood vessel remodeling GO:0050730: regulation of peptidyl-tyrosine phosphorylation GO:0016853: isomerase activity GO:0007599: hemostasis GO:0032312: regulation of ARF GTPase activity GO:0043122: regulation of I-kappaB kinase/NF-kappaB cascade GO:0006302: double-strand break repair GO:0043407: negative regulation of MAP kinase activity GO:0006412: translation GO:0048027: mRNA 5'-UTR binding GO:0001725: stress fiber GO:0016049: cell growth GO:0031667: response to nutrient levels GO:0060042: retina morphogenesis in camera-type eye GO:0050811: GABA receptor binding GO:0060214: endocardium formation GO:0015026: coreceptor activity GO:0015807: L-amino acid transport GO:0009791: post-embryonic development GO:0030246: carbohydrate binding GO:0043406: positive regulation of MAP kinase activity GO:0008466: glycogenin glucosyltransferase activity GO:0006297: nucleotide-excision repair, DNA gap filling GO:0046620: regulation of organ growth GO:0048012: hepatocyte growth factor receptor signaling pathway GO:0005484: SNAP receptor activity GO:0021516: dorsal spinal cord development GO:0009410: response to xenobiotic stimulus GO:0008156: negative regulation of DNA replication GO:0031072: heat shock protein binding GO:0060009: Sertoli cell development GO:0007628: adult walking behavior GO:0005782: peroxisomal matrix GO:0006491: N-glycan processing GO:0032947: protein complex scaffold GO:0045768: positive regulation of anti-apoptosis GO:0004527: exonuclease activity GO:0008060: ARF GTPase activator activity GO:0042789: mRNA transcription from RNA polymerase II promoter GO:0008654: phospholipid biosynthetic process GO:0047485: protein N-terminus binding GO:0009437: carnitine metabolic process GO:0005008: hepatocyte growth factor receptor activity GO:0004221: ubiquitin thiolesterase activity GO:0030276: clathrin binding GO:0000036: acyl carrier activity GO:0030504: inorganic diphosphate transmembrane transporter activity GO:0006820: anion transport GO:0015015: heparan sulfate proteoglycan biosynthetic process, enzymatic modification GO:0004519: endonuclease activity GO:0031201: SNARE complex GO:0015271: outward rectifier potassium channel activity GO:0005978: glycogen biosynthetic process GO:0045351: type I interferon biosynthetic process GO:0030910: olfactory placode formation GO:0016758: transferase activity, transferring hexosyl groups GO:0019674: NAD metabolic process GO:0000723: telomere maintenance GO:0015459: potassium channel regulator activity GO:0016579: protein deubiquitination GO:0009058: biosynthetic process GO:0042326: negative regulation of phosphorylation GO:0004571: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0042133: neurotransmitter metabolic process GO:0043049: otic placode formation GO:0001709: cell fate determination GO:0016790: thiolester hydrolase activity GO:0008210: estrogen metabolic process GO:0003955: NAD(P)H dehydrogenase (quinone) activity GO:0050930: induction of positive chemotaxis GO:0015923: mannosidase activity GO:0001568: blood vessel development GO:0030532: small nuclear ribonucleoprotein complex GO:0042056: chemoattractant activity GO:0033872: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity GO:0060041: retina development in camera-type eye GO:0008191: metalloendopeptidase inhibitor activity GO:0005819: spindle GO:0016538: cyclin-dependent protein kinase regulator activity GO:0046329: negative regulation of JNK cascade GO:0021522: spinal cord motor neuron differentiation GO:0006516: glycoprotein catabolic process GO:0016605: PML body GO:0019319: hexose biosynthetic process GO:0004869: cysteine-type endopeptidase inhibitor activity GO:0032940: secretion by cell GO:0021702: cerebellar Purkinje cell differentiation GO:0051879: Hsp90 protein binding GO:0019864: IgG binding GO:0004128: cytochrome-b5 reductase activity GO:0000076: DNA replication checkpoint GO:0005801: cis-Golgi network GO:0008503: benzodiazepine receptor activity GO:0003993: acid phosphatase activity GO:0006665: sphingolipid metabolic process GO:0047391: alkylglycerophosphoethanolamine phosphodiesterase activity GO:0000118: histone deacetylase complex GO:0005519: cytoskeletal regulatory protein binding GO:0021915: neural tube development GO:0016126: sterol biosynthetic process GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds GO:0045807: positive regulation of endocytosis GO:0015179: L-amino acid transmembrane transporter activity GO:0060076: excitatory synapse GO:0042035: regulation of cytokine biosynthetic process GO:0008565: protein transporter activity GO:0035264: multicellular organism growth GO:0032769: negative regulation of monooxygenase activity GO:0019956: chemokine binding GO:0034341: response to interferon-gamma GO:0046928: regulation of neurotransmitter secretion GO:0017053: transcriptional repressor complex GO:0005315: inorganic phosphate transmembrane transporter activity GO:0048511: rhythmic process GO:0016197: endosome transport GO:0004683: calmodulin-dependent protein kinase activity GO:0000151: ubiquitin ligase complex GO:0004721: phosphoprotein phosphatase activity GO:0055005: ventricular cardiac myofibril development GO:0007412: axon target recognition GO:0006289: nucleotide-excision repair GO:0008379: thioredoxin peroxidase activity GO:0004622: lysophospholipase activity GO:0006044: N-acetylglucosamine metabolic process GO:0048247: lymphocyte chemotaxis GO:0051045: negative regulation of membrane protein ectodomain proteolysis GO:0008354: germ cell migration GO:0004091: carboxylesterase activity GO:0042744: hydrogen peroxide catabolic process GO:0060048: cardiac muscle contraction GO:0019867: outer membrane GO:0009925: basal plasma membrane #1051IR #1083IR 1 GO:0005499: vitamin D binding #1063IR #1083IR 25 GO:0043259: laminin-10 complex GO:0042730: fibrinolysis GO:0045103: intermediate filament-based process GO:0005099: Ras GTPase activator activity GO:0005513: detection of calcium ion GO:0043257: laminin-8 complex GO:0030666: endocytic vesicle membrane GO:0030889: negative regulation of B cell proliferation GO:0050919: negative chemotaxis GO:0045666: positive regulation of neuron differentiation GO:0045499: chemorepellent activity GO:0021545: cranial nerve development GO:0007140: male meiosis GO:0043292: contractile fiber GO:0006968: cellular defense response GO:0035249: synaptic transmission, glutamatergic GO:0002027: regulation of heart rate GO:0007499: ectoderm and mesoderm interaction GO:0042986: positive regulation of amyloid precursor protein biosynthetic process GO:0005607: laminin-2 complex GO:0001843: neural tube closure GO:0007128: meiotic prophase I GO:0001736: establishment of planar polarity GO:0009314: response to radiation GO:0042094: interleukin-2 biosynthetic process #1051IR #1063IR 10 GO:0016308: 1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0048156: tau protein binding GO:0031018: endocrine pancreas development GO:0005898: interleukin-13 receptor complex GO:0032092: positive regulation of protein binding GO:0005596: collagen type XIV GO:0048814: regulation of dendrite morphogenesis GO:0014056: regulation of acetylcholine secretion GO:0045210: FasL biosynthetic process GO:0001822: kidney development #10IR 552 GO:0008475: procollagen-lysine 5-dioxygenase activity GO:0032318: regulation of Ras GTPase activity GO:0006208: pyrimidine base catabolic process GO:0045995: regulation of embryonic development GO:0031849: olfactory receptor binding GO:0001841: neural tube formation GO:0032757: positive regulation of interleukin-8 production GO:0005913: cell-cell adherens junction GO:0016071: mRNA metabolic process GO:0032714: negative regulation of interleukin-5 production GO:0071565: nBAF complex GO:0045909: positive regulation of vasodilation GO:0032376: positive regulation of cholesterol transport GO:0007502: digestive tract mesoderm development GO:0045785: positive regulation of cell adhesion GO:0034993: SUN-KASH complex GO:0071285: cellular response to lithium ion GO:0005220: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0035590: purinergic nucleotide receptor signaling pathway GO:0010976: positive regulation of neuron projection development GO:0048625: myoblast cell fate commitment GO:0031683: G-protein beta/gamma-subunit complex binding GO:0070826: paraferritin complex GO:0016051: carbohydrate biosynthetic process GO:0051495: positive regulation of cytoskeleton organization GO:0007250: activation of NF-kappaB-inducing kinase activity GO:2000062: negative regulation of ureter smooth muscle cell differentiation GO:0031313: extrinsic to endosome membrane GO:0050434: positive regulation of viral transcription GO:0015238: drug transmembrane transporter activity GO:0060046: regulation of acrosome reaction GO:0031095: platelet dense tubular network membrane GO:0031090: organelle membrane GO:0016540: protein autoprocessing GO:0060662: salivary gland cavitation GO:0001574: ganglioside biosynthetic process GO:0060405: regulation of penile erection GO:0043410: positive regulation of MAPKKK cascade GO:0043132: NAD transport GO:0021882: regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment GO:0019985: translesion synthesis GO:0048844: artery morphogenesis GO:0030151: molybdenum ion binding GO:0048859: formation of anatomical boundary GO:0031094: platelet dense tubular network GO:0021940: positive regulation of cerebellar granule cell precursor proliferation GO:0004461: lactose synthase activity GO:0051209: release of sequestered calcium ion into cytosol GO:0009101: glycoprotein biosynthetic process GO:0060782: regulation of mesenchymal cell proliferation involved in prostate gland development GO:0010288: response to lead ion GO:0022602: ovulation cycle process GO:0001916: positive regulation of T cell mediated cytotoxicity GO:0014902: myotube differentiation GO:0008269: JAK pathway signal transduction adaptor activity GO:0043369: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment GO:0005989: lactose biosynthetic process GO:0003214: cardiac left ventricle morphogenesis GO:0071421: manganese ion transmembrane transport GO:0070447: positive regulation of oligodendrocyte progenitor proliferation GO:0030331: estrogen receptor binding GO:0030854: positive regulation of granulocyte differentiation GO:0015295: solute:hydrogen symporter activity GO:0070682: proteasome regulatory particle assembly GO:2000114: regulation of establishment of cell polarity GO:0051901: positive regulation of mitochondrial depolarization GO:0007340: acrosome reaction GO:0034141: positive regulation of toll-like receptor 3 signaling pathway GO:0034364: high-density lipoprotein particle GO:0045741: positive regulation of epidermal growth factor receptor activity GO:0046578: regulation of Ras protein signal transduction GO:0030332: cyclin binding GO:0021893: cerebral cortex GABAergic interneuron fate commitment GO:0045727: positive regulation of translation GO:0070574: cadmium ion transmembrane transport GO:0046686: response to cadmium ion GO:0031572: G2/M transition DNA damage checkpoint GO:0042733: embryonic digit morphogenesis GO:0005814: centriole GO:0004087: carbamoyl-phosphate synthase (ammonia) activity GO:0032000: positive regulation of fatty acid beta-oxidation GO:0032229: negative regulation of synaptic transmission, GABAergic GO:0051001: negative regulation of nitric-oxide synthase activity GO:0042489: negative regulation of odontogenesis of dentine-containing tooth GO:0033017: sarcoplasmic reticulum membrane GO:0031214: biomineral tissue development GO:0006801: superoxide metabolic process GO:0010042: response to manganese ion GO:0016925: protein sumoylation GO:0032648: regulation of interferon-beta production GO:0051938: L-glutamate import GO:0009331: glycerol-3-phosphate dehydrogenase complex GO:0070053: thrombospondin receptor activity GO:0006196: AMP catabolic process GO:0071223: cellular response to lipoteichoic acid GO:0055072: iron ion homeostasis GO:0003727: single-stranded RNA binding GO:0031999: negative regulation of fatty acid beta-oxidation GO:0035253: ciliary rootlet GO:0051496: positive regulation of stress fiber assembly GO:0071864: positive regulation of cell proliferation in bone marrow GO:0051894: positive regulation of focal adhesion assembly GO:0005639: integral to nuclear inner membrane GO:0045759: negative regulation of action potential GO:0050715: positive regulation of cytokine secretion GO:0071866: negative regulation of apoptosis in bone marrow GO:0006349: regulation of gene expression by genetic imprinting GO:0045136: development of secondary sexual characteristics GO:0040038: polar body extrusion after meiotic divisions GO:0005313: L-glutamate transmembrane transporter activity GO:0030388: fructose 1,6-bisphosphate metabolic process GO:0015085: calcium ion transmembrane transporter activity GO:0050829: defense response to Gram-negative bacterium GO:2000343: positive regulation of chemokine (C-X-C motif) ligand 2 production GO:0070409: carbamoyl phosphate biosynthetic process GO:0005113: patched binding GO:0005351: sugar:hydrogen symporter activity GO:0018119: peptidyl-cysteine S-nitrosylation GO:0034618: arginine binding GO:0042153: RPTP-like protein binding GO:0030155: regulation of cell adhesion GO:0004368: glycerol-3-phosphate dehydrogenase activity GO:0005795: Golgi stack GO:0008253: 5'-nucleotidase activity GO:0005094: Rho GDP-dissociation inhibitor activity GO:0016528: sarcoplasm GO:0015676: vanadium ion transport GO:0042098: T cell proliferation GO:0015631: tubulin binding GO:0004499: flavin-containing monooxygenase activity GO:0060439: trachea morphogenesis GO:0015100: vanadium ion transmembrane transporter activity GO:0015299: solute:hydrogen antiporter activity GO:0007228: positive regulation of hh target transcription factor activity GO:0043923: positive regulation by host of viral transcription GO:0035434: copper ion transmembrane transport GO:0031953: negative regulation of protein autophosphorylation GO:0046685: response to arsenic-containing substance GO:0048715: negative regulation of oligodendrocyte differentiation GO:0004835: tubulin-tyrosine ligase activity GO:0006004: fucose metabolic process GO:0006956: complement activation GO:0071548: response to dexamethasone stimulus GO:0016151: nickel ion binding GO:0045880: positive regulation of smoothened signaling pathway GO:0090022: regulation of neutrophil chemotaxis GO:0006651: diacylglycerol biosynthetic process GO:0005104: fibroblast growth factor receptor binding GO:0031981: nuclear lumen GO:0070679: inositol 1,4,5 trisphosphate binding GO:0046168: glycerol-3-phosphate catabolic process GO:0042178: xenobiotic catabolic process GO:0001660: fever generation GO:0007494: midgut development GO:0014043: negative regulation of neuron maturation GO:0035444: nickel ion transmembrane transport GO:0030131: clathrin adaptor complex GO:0050482: arachidonic acid secretion GO:0032993: protein-DNA complex GO:0061056: sclerotome development GO:0048592: eye morphogenesis GO:0090068: positive regulation of cell cycle process GO:0060783: mesenchymal smoothened signaling pathway involved in prostate gland development GO:2000357: negative regulation of kidney smooth muscle cell differentiation GO:0002793: positive regulation of peptide secretion GO:0035663: Toll-like receptor 2 binding GO:0007224: smoothened signaling pathway GO:0007132: meiotic metaphase I GO:0060406: positive regulation of penile erection GO:0015884: folic acid transport GO:0006972: hyperosmotic response GO:0045178: basal part of cell GO:0050717: positive regulation of interleukin-1 alpha secretion GO:0006649: phospholipid transfer to membrane GO:0046888: negative regulation of hormone secretion GO:0006868: glutamine transport GO:0004607: phosphatidylcholine-sterol O-acyltransferase activity GO:0060259: regulation of feeding behavior GO:0034501: protein localization to kinetochore GO:0032060: bleb assembly GO:0032348: negative regulation of aldosterone biosynthetic process GO:0043032: positive regulation of macrophage activation GO:0032224: positive regulation of synaptic transmission, cholinergic GO:0035326: enhancer binding GO:0060025: regulation of synaptic activity GO:0001658: branching involved in ureteric bud morphogenesis GO:0060428: lung epithelium development GO:0051155: positive regulation of striated muscle cell differentiation GO:0016628: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0004560: alpha-L-fucosidase activity GO:0009411: response to UV GO:0005610: laminin-5 complex GO:0043236: laminin binding GO:0010039: response to iron ion GO:0060458: right lung development GO:0060135: maternal process involved in female pregnancy GO:0007097: nuclear migration GO:0008417: fucosyltransferase activity GO:0006930: substrate-dependent cell migration, cell extension GO:0033004: negative regulation of mast cell activation GO:0048738: cardiac muscle tissue development GO:0048714: positive regulation of oligodendrocyte differentiation GO:0022408: negative regulation of cell-cell adhesion GO:0046639: negative regulation of alpha-beta T cell differentiation GO:0072568: protein kinase C delta binding GO:0035091: phosphatidylinositol binding GO:0032738: positive regulation of interleukin-15 production GO:0030049: muscle filament sliding GO:0001759: organ induction GO:0003990: acetylcholinesterase activity GO:0003032: detection of oxygen GO:0003093: regulation of glomerular filtration GO:0016344: meiotic chromosome movement towards spindle pole GO:0015116: sulfate transmembrane transporter activity GO:0050031: L-pipecolate oxidase activity GO:0050995: negative regulation of lipid catabolic process GO:0045652: regulation of megakaryocyte differentiation GO:0003407: neural retina development GO:0008272: sulfate transport GO:0016539: intein-mediated protein splicing GO:0007009: plasma membrane organization GO:0030030: cell projection organization GO:0031668: cellular response to extracellular stimulus GO:0006828: manganese ion transport GO:0042323: negative regulation of circadian sleep/wake cycle, non-REM sleep GO:0004950: chemokine receptor activity GO:0006884: cell volume homeostasis GO:0030284: estrogen receptor activity GO:0033198: response to ATP GO:0045059: positive thymic T cell selection GO:0015093: ferrous iron transmembrane transporter activity GO:0045822: negative regulation of heart contraction GO:0016514: SWI/SNF complex GO:0051712: positive regulation of killing of cells of other organism GO:0045777: positive regulation of blood pressure GO:0033077: T cell differentiation in thymus GO:0044429: mitochondrial part GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0014732: skeletal muscle atrophy GO:0005640: nuclear outer membrane GO:0005588: collagen type V GO:0004367: glycerol-3-phosphate dehydrogenase [NAD+] activity GO:0031022: nuclear migration along microfilament GO:0045776: negative regulation of blood pressure GO:0009953: dorsal/ventral pattern formation GO:0042474: middle ear morphogenesis GO:0030126: COPI vesicle coat GO:0005384: manganese ion transmembrane transporter activity GO:0048617: embryonic foregut morphogenesis GO:0008209: androgen metabolic process GO:0001955: blood vessel maturation GO:0000185: activation of MAPKKK activity GO:0046534: positive regulation of photoreceptor cell differentiation GO:0034123: positive regulation of toll-like receptor signaling pathway GO:0006839: mitochondrial transport GO:0048771: tissue remodeling GO:0004332: fructose-bisphosphate aldolase activity GO:0033265: choline binding GO:0050718: positive regulation of interleukin-1 beta secretion GO:0001614: purinergic nucleotide receptor activity GO:0060738: epithelial-mesenchymal signaling involved in prostate gland development GO:0008353: RNA polymerase II carboxy-terminal domain kinase activity GO:0045779: negative regulation of bone resorption GO:0006900: membrane budding GO:0007217: tachykinin receptor signaling pathway GO:0004931: extracellular ATP-gated cation channel activity GO:0032308: positive regulation of prostaglandin secretion GO:0006259: DNA metabolic process GO:0070097: delta-catenin binding GO:0090073: positive regulation of protein homodimerization activity GO:0001708: cell fate specification GO:0008504: monoamine transmembrane transporter activity GO:0060586: multicellular organismal iron ion homeostasis GO:0051967: negative regulation of synaptic transmission, glutamatergic GO:0005148: prolactin receptor binding GO:0047496: vesicle transport along microtubule GO:0032728: positive regulation of interferon-beta production GO:0048645: organ formation GO:0045359: positive regulation of interferon-beta biosynthetic process GO:0046486: glycerolipid metabolic process GO:0030658: transport vesicle membrane GO:0015385: sodium:hydrogen antiporter activity GO:0004301: epoxide hydrolase activity GO:0051287: NAD binding GO:0021978: telencephalon regionalization GO:0010467: gene expression GO:0001845: phagolysosome assembly GO:0042301: phosphate binding GO:0007520: myoblast fusion GO:0045410: positive regulation of interleukin-6 biosynthetic process GO:0030035: microspike assembly GO:0021772: olfactory bulb development GO:0048016: inositol phosphate-mediated signaling GO:0032228: regulation of synaptic transmission, GABAergic GO:0060020: Bergmann glial cell differentiation GO:0060054: positive regulation of epithelial cell proliferation involved in wound healing GO:0021521: ventral spinal cord interneuron specification GO:0034339: regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor GO:0044325: ion channel binding GO:0090197: positive regulation of chemokine secretion GO:0055038: recycling endosome membrane GO:0005367: myo-inositol:sodium symporter activity GO:0045356: positive regulation of interferon-alpha biosynthetic process GO:0071221: cellular response to bacterial lipopeptide GO:0008970: phospholipase A1 activity GO:0050897: cobalt ion binding GO:0007032: endosome organization GO:0035662: Toll-like receptor 4 binding GO:0071353: cellular response to interleukin-4 GO:0034145: positive regulation of toll-like receptor 4 signaling pathway GO:0007339: binding of sperm to zona pellucida GO:0045908: negative regulation of vasodilation GO:0051437: positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0072136: metanephric mesenchymal cell proliferation involved in metanephros development GO:0019532: oxalate transport GO:0045294: alpha-catenin binding GO:0009629: response to gravity GO:0051709: regulation of killing of cells of other organism GO:0006937: regulation of muscle contraction GO:0005290: L-histidine transmembrane transporter activity GO:0010983: positive regulation of high-density lipoprotein particle clearance GO:0009922: fatty acid elongase activity GO:0033602: negative regulation of dopamine secretion GO:0002866: positive regulation of acute inflammatory response to antigenic stimulus GO:0005605: basal lamina GO:0090041: negative regulation of gene-specific transcription elongation from RNA polymerase II promoter GO:0030223: neutrophil differentiation GO:0051295: establishment of meiotic spindle localization GO:0050661: NADP binding GO:0034617: tetrahydrobiopterin binding GO:0015099: nickel ion transmembrane transporter activity GO:0007418: ventral midline development GO:0010977: negative regulation of neuron projection development GO:0000050: urea cycle GO:0017034: Rap guanyl-nucleotide exchange factor activity GO:0022890: inorganic cation transmembrane transporter activity GO:0031526: brush border membrane GO:0019531: oxalate transmembrane transporter activity GO:0019290: siderophore biosynthetic process GO:0035250: UDP-galactosyltransferase activity GO:0048484: enteric nervous system development GO:0002028: regulation of sodium ion transport GO:0001530: lipopolysaccharide binding GO:0032696: negative regulation of interleukin-13 production GO:0016578: histone deubiquitination GO:0001609: adenosine receptor activity, G-protein coupled GO:0046086: adenosine biosynthetic process GO:0051436: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0090286: cytoskeletal anchoring at nuclear membrane GO:0051270: regulation of cellular component movement GO:0034230: enkephalin processing GO:2000065: negative regulation of cortisol biosynthetic process GO:0046931: pore complex assembly GO:0042761: very long-chain fatty acid biosynthetic process GO:0032900: negative regulation of neurotrophin production GO:0046653: tetrahydrofolate metabolic process GO:0016986: transcription initiation factor activity GO:0030183: B cell differentiation GO:0004517: nitric-oxide synthase activity GO:0006195: purine nucleotide catabolic process GO:0003725: double-stranded RNA binding GO:0006829: zinc ion transport GO:0014741: negative regulation of muscle hypertrophy GO:0045060: negative thymic T cell selection GO:0048589: developmental growth GO:0035665: TIRAP-dependent toll-like receptor 4 signaling pathway GO:0014050: negative regulation of glutamate secretion GO:0019240: citrulline biosynthetic process GO:0071400: cellular response to oleic acid GO:0030502: negative regulation of bone mineralization GO:0002076: osteoblast development GO:0010043: response to zinc ion GO:0008095: inositol-1,4,5-trisphosphate receptor activity GO:0033276: transcription factor TFTC complex GO:0015817: histidine transport GO:0072199: regulation of mesenchymal cell proliferation involved in ureter development GO:0015182: L-asparagine transmembrane transporter activity GO:0002087: regulation of respiratory gaseous exchange by neurological system process GO:0004513: neolactotetraosylceramide alpha-2,3-sialyltransferase activity GO:0031821: metabotropic serotonin receptor binding GO:0005218: intracellular ligand-gated calcium channel activity GO:0014054: positive regulation of gamma-aminobutyric acid secretion GO:0035338: long-chain fatty-acyl-CoA biosynthetic process GO:0032835: glomerulus development GO:0034405: response to fluid shear stress GO:0021513: spinal cord dorsal/ventral patterning GO:0030856: regulation of epithelial cell differentiation GO:0043271: negative regulation of ion transport GO:0045078: positive regulation of interferon-gamma biosynthetic process GO:0051290: protein heterotetramerization GO:0071899: negative regulation of estrogen receptor binding GO:0005131: growth hormone receptor binding GO:0071577: zinc ion transmembrane transport GO:2000063: positive regulation of ureter smooth muscle cell differentiation GO:2000358: positive regulation of kidney smooth muscle cell differentiation GO:0031527: filopodium membrane GO:0002227: innate immune response in mucosa GO:0006116: NADH oxidation GO:0048864: stem cell development GO:0050543: icosatetraenoic acid binding GO:0031685: adenosine receptor binding GO:0002320: lymphoid progenitor cell differentiation GO:0015094: lead ion transmembrane transporter activity GO:0060326: cell chemotaxis GO:0070627: ferrous iron import GO:0030574: collagen catabolic process GO:0004864: protein phosphatase inhibitor activity GO:0031117: positive regulation of microtubule depolymerization GO:0046923: ER retention sequence binding GO:0006513: protein monoubiquitination GO:0031088: platelet dense granule membrane GO:0045063: T-helper 1 cell differentiation GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0030010: establishment of cell polarity GO:0071436: sodium ion export GO:0003858: 3-hydroxybutyrate dehydrogenase activity GO:0042589: zymogen granule membrane GO:0044212: transcription regulatory region DNA binding GO:0043967: histone H4 acetylation GO:0034597: phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity GO:0016358: dendrite development GO:0034605: cellular response to heat GO:0051642: centrosome localization GO:0004095: carnitine O-palmitoyltransferase activity GO:0006612: protein targeting to membrane GO:0042307: positive regulation of protein import into nucleus GO:0060170: cilium membrane GO:0070542: response to fatty acid GO:0032059: bleb GO:0032403: protein complex binding GO:0015844: monoamine transport GO:0042100: B cell proliferation GO:0050805: negative regulation of synaptic transmission GO:0000293: ferric-chelate reductase activity GO:0016791: phosphatase activity GO:0060058: positive regulation of apoptosis involved in mammary gland involution GO:0060685: regulation of prostatic bud formation GO:0048643: positive regulation of skeletal muscle tissue development GO:0032435: negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0030099: myeloid cell differentiation GO:0031581: hemidesmosome assembly GO:0016485: protein processing GO:0003831: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity GO:0008020: G-protein coupled photoreceptor activity GO:0055118: negative regulation of cardiac muscle contraction GO:0006406: mRNA export from nucleus GO:0008540: proteasome regulatory particle, base subcomplex GO:0002064: epithelial cell development GO:0046513: ceramide biosynthetic process GO:0002162: dystroglycan binding GO:0034231: islet amyloid polypeptide processing GO:0006621: protein retention in ER lumen GO:0015106: bicarbonate transmembrane transporter activity GO:0009584: detection of visible light GO:0047291: lactosylceramide alpha-2,3-sialyltransferase activity GO:0016998: cell wall macromolecule catabolic process GO:0034626: fatty acid elongation, polyunsaturated fatty acid GO:0060447: bud outgrowth involved in lung branching GO:0060840: artery development GO:0060516: primary prostatic bud elongation GO:0042346: positive regulation of NF-kappaB import into nucleus GO:0046632: alpha-beta T cell differentiation GO:0001912: positive regulation of leukocyte mediated cytotoxicity GO:0046332: SMAD binding GO:0043615: astrocyte cell migration GO:0031100: organ regeneration GO:0033092: positive regulation of immature T cell proliferation in thymus GO:0042168: heme metabolic process GO:0001578: microtubule bundle formation GO:0000138: Golgi trans cisterna GO:2000340: positive regulation of chemokine (C-X-C motif) ligand 1 production GO:0014858: positive regulation of skeletal muscle cell proliferation GO:0030112: glycocalyx GO:0051895: negative regulation of focal adhesion assembly GO:0044344: cellular response to fibroblast growth factor stimulus GO:0048646: anatomical structure formation involved in morphogenesis GO:0007026: negative regulation of microtubule depolymerization GO:0007442: hindgut morphogenesis GO:0006470: protein dephosphorylation GO:0043401: steroid hormone mediated signaling pathway GO:0048632: negative regulation of skeletal muscle tissue growth GO:0016615: malate dehydrogenase activity GO:0045445: myoblast differentiation GO:0001948: glycoprotein binding GO:0034137: positive regulation of toll-like receptor 2 signaling pathway GO:0015684: ferrous iron transport GO:0006867: asparagine transport GO:0048821: erythrocyte development GO:0030070: insulin processing GO:0014706: striated muscle tissue development GO:0015301: anion:anion antiporter activity GO:0043268: positive regulation of potassium ion transport GO:0060459: left lung development GO:0050746: regulation of lipoprotein metabolic process GO:0021938: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0015086: cadmium ion transmembrane transporter activity GO:0004086: carbamoyl-phosphate synthase activity GO:0043279: response to alkaloid GO:0009597: detection of virus GO:0042308: negative regulation of protein import into nucleus GO:0007257: activation of JUN kinase activity GO:0006000: fructose metabolic process GO:0031464: Cul4A-RING ubiquitin ligase complex GO:0004629: phospholipase C activity GO:0010740: positive regulation of intracellular protein kinase cascade GO:0019834: phospholipase A2 inhibitor activity GO:0015081: sodium ion transmembrane transporter activity GO:0030878: thyroid gland development GO:0021904: dorsal/ventral neural tube patterning GO:0060769: positive regulation of epithelial cell proliferation involved in prostate gland development GO:0031465: Cul4B-RING ubiquitin ligase complex GO:0019395: fatty acid oxidation GO:0034435: cholesterol esterification GO:0019367: fatty acid elongation, saturated fatty acid GO:0043392: negative regulation of DNA binding GO:0043587: tongue morphogenesis GO:0008486: diphosphoinositol-polyphosphate diphosphatase activity GO:0015087: cobalt ion transmembrane transporter activity GO:0017144: drug metabolic process GO:0032244: positive regulation of nucleoside transport GO:0032795: heterotrimeric G-protein binding GO:0004402: histone acetyltransferase activity GO:0043029: T cell homeostasis GO:0003920: GMP reductase activity GO:0030914: STAGA complex GO:0015675: nickel ion transport GO:0006824: cobalt ion transport GO:0005932: microtubule basal body GO:0005385: zinc ion transmembrane transporter activity GO:0008328: ionotropic glutamate receptor complex GO:0006606: protein import into nucleus GO:0032735: positive regulation of interleukin-12 production GO:0032713: negative regulation of interleukin-4 production GO:0005272: sodium channel activity GO:0002052: positive regulation of neuroblast proliferation GO:0080125: multicellular structure septum development GO:0044254: multicellular organismal protein catabolic process GO:0032591: dendritic spine membrane GO:0048155: S100 alpha binding GO:0016705: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0030742: GTP-dependent protein binding GO:0008115: sarcosine oxidase activity GO:0015692: lead ion transport GO:0030217: T cell differentiation GO:0070779: D-aspartate import GO:0005542: folic acid binding GO:0050965: detection of temperature stimulus involved in sensory perception of pain GO:0070016: armadillo repeat domain binding GO:0055081: anion homeostasis GO:0042158: lipoprotein biosynthetic process GO:0048314: embryo sac morphogenesis GO:0005324: long-chain fatty acid transporter activity #1095IR 716 GO:0048676: axon extension involved in development GO:0032052: bile acid binding GO:0009790: embryonic development GO:0006807: nitrogen compound metabolic process GO:0007519: skeletal muscle development GO:0007212: dopamine receptor signaling pathway GO:0009434: microtubule-based flagellum GO:0010766: negative regulation of sodium ion transport GO:0005761: mitochondrial ribosome GO:0050665: hydrogen peroxide biosynthetic process GO:0004828: serine-tRNA ligase activity GO:0004017: adenylate kinase activity GO:0032781: positive regulation of ATPase activity GO:0004813: alanine-tRNA ligase activity GO:0043754: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity GO:0031105: septin complex GO:0006413: translational initiation GO:0019911: structural constituent of myelin sheath GO:0046933: hydrogen ion transporting ATP synthase activity, rotational mechanism GO:0004579: dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0042384: cilium assembly GO:0014068: positive regulation of phosphoinositide 3-kinase cascade GO:0045747: positive regulation of Notch signaling pathway GO:0019835: cytolysis GO:0043507: positive regulation of JUN kinase activity GO:0005885: Arp2/3 protein complex GO:0051603: proteolysis involved in cellular protein catabolic process GO:0009755: hormone-mediated signaling GO:0006857: oligopeptide transport GO:0051538: 3 iron, 4 sulfur cluster binding GO:0004825: methionine-tRNA ligase activity GO:0033179: proton-transporting V-type ATPase, V0 domain GO:0004347: glucose-6-phosphate isomerase activity GO:0043498: cell surface binding GO:0009086: methionine biosynthetic process GO:0003983: UTP:glucose-1-phosphate uridylyltransferase activity GO:0006694: steroid biosynthetic process GO:0008494: translation activator activity GO:0018193: peptidyl-amino acid modification GO:0047042: 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity GO:0031571: G1 DNA damage checkpoint GO:0003954: NADH dehydrogenase activity GO:0042511: positive regulation of tyrosine phosphorylation of Stat1 protein GO:0015520: tetracycline:hydrogen antiporter activity GO:0051346: negative regulation of hydrolase activity GO:0004800: thyroxine 5'-deiodinase activity GO:0003980: UDP-glucose:glycoprotein glucosyltransferase activity GO:0006590: thyroid hormone generation GO:0045636: positive regulation of melanocyte differentiation GO:0001601: peptide YY receptor activity GO:0031669: cellular response to nutrient levels GO:0051016: barbed-end actin filament capping GO:0048269: methionine adenosyltransferase complex GO:0005151: interleukin-1, Type II receptor binding GO:0035091: phosphoinositide binding GO:0004337: geranyltranstransferase activity GO:0000224: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity GO:0004984: olfactory receptor activity GO:0046902: regulation of mitochondrial membrane permeability GO:0005762: mitochondrial large ribosomal subunit GO:0016229: steroid dehydrogenase activity GO:0050815: phosphoserine binding GO:0018879: biphenyl metabolic process GO:0007369: gastrulation GO:0019902: phosphatase binding GO:0045298: tubulin complex GO:0005000: vasopressin receptor activity GO:0017183: peptidyl-diphthamide biosynthetic process from peptidyl-histidine GO:0005839: proteasome core complex GO:0005763: mitochondrial small ribosomal subunit GO:0005859: muscle myosin complex GO:0006563: L-serine metabolic process GO:0015457: auxiliary transport protein activity GO:0015272: ATP-activated inward rectifier potassium channel activity GO:0005643: nuclear pore GO:0046934: phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0001945: lymph vessel development GO:0021954: central nervous system neuron development GO:0046961: proton-transporting ATPase activity, rotational mechanism GO:0032287: myelin maintenance in the peripheral nervous system GO:0008061: chitin binding GO:0008449: N-acetylglucosamine-6-sulfatase activity GO:0045815: positive regulation of gene expression, epigenetic GO:0052171: growth or development during symbiotic interaction GO:0015450: P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0016786: selenotransferase activity GO:0019008: molybdopterin synthase complex GO:0006368: RNA elongation from RNA polymerase II promoter GO:0045475: locomotor rhythm GO:0004697: protein kinase C activity GO:0006519: cellular amino acid and derivative metabolic process GO:0045840: positive regulation of mitosis GO:0001895: retina homeostasis GO:0005942: phosphoinositide 3-kinase complex GO:0005744: mitochondrial inner membrane presequence translocase complex GO:0004905: type I interferon receptor activity GO:0006431: methionyl-tRNA aminoacylation GO:0051146: striated muscle cell differentiation GO:0002318: myeloid progenitor cell differentiation GO:0006027: glycosaminoglycan catabolic process GO:0048861: leukemia inhibitory factor signaling pathway GO:0004035: alkaline phosphatase activity GO:0035254: glutamate receptor binding GO:0004743: pyruvate kinase activity GO:0008479: queuine tRNA-ribosyltransferase activity GO:0004174: electron-transferring-flavoprotein dehydrogenase activity GO:0015904: tetracycline transport GO:0032729: positive regulation of interferon-gamma production GO:0018345: protein palmitoylation GO:0016846: carbon-sulfur lyase activity GO:0003729: mRNA binding GO:0043209: myelin sheath GO:0005851: eukaryotic translation initiation factor 2B complex GO:0050661: NADP or NADPH binding GO:0000275: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) GO:0000119: mediator complex GO:0005746: mitochondrial respiratory chain GO:0004656: procollagen-proline 4-dioxygenase activity GO:0030515: snoRNA binding GO:0042423: catecholamine biosynthetic process GO:0001817: regulation of cytokine production GO:0032038: myosin II heavy chain binding GO:0004771: sterol esterase activity GO:0015248: sterol transporter activity GO:0004569: glycoprotein endo-alpha-1,2-mannosidase activity GO:0008616: queuosine biosynthetic process GO:0006817: phosphate transport GO:0005139: interleukin-7 receptor binding GO:0051450: myoblast proliferation GO:0000247: C-8 sterol isomerase activity GO:0006122: mitochondrial electron transport, ubiquinol to cytochrome c GO:0030060: L-malate dehydrogenase activity GO:0033119: negative regulation of RNA splicing GO:0009303: rRNA transcription GO:0045648: positive regulation of erythrocyte differentiation GO:0008177: succinate dehydrogenase (ubiquinone) activity GO:0004134: 4-alpha-glucanotransferase activity GO:0045899: positive regulation of transcriptional preinitiation complex assembly GO:0019206: nucleoside kinase activity GO:0000254: C-4 methylsterol oxidase activity GO:0004504: peptidylglycine monooxygenase activity GO:0051287: NAD or NADH binding GO:0050840: extracellular matrix binding GO:0042491: auditory receptor cell differentiation GO:0008353: RNA polymerase subunit kinase activity GO:0005173: stem cell factor receptor binding GO:0006904: vesicle docking during exocytosis GO:0004587: ornithine-oxo-acid transaminase activity GO:0034464: BBSome GO:0044237: cellular metabolic process GO:0004897: ciliary neurotrophic factor receptor activity GO:0032801: receptor catabolic process GO:0006298: mismatch repair GO:0042273: ribosomal large subunit biogenesis GO:0006544: glycine metabolic process GO:0045446: endothelial cell differentiation GO:0008190: eukaryotic initiation factor 4E binding GO:0004165: dodecenoyl-CoA delta-isomerase activity GO:0003906: DNA-(apurinic or apyrimidinic site) lyase activity GO:0004008: copper-exporting ATPase activity GO:0045261: proton-transporting ATP synthase complex, catalytic core F(1) GO:0002262: myeloid cell homeostasis GO:0004487: methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0045794: negative regulation of cell volume GO:0018279: protein amino acid N-linked glycosylation via asparagine GO:0006338: chromatin remodeling GO:0060163: subpallium neuron fate commitment GO:0046677: response to antibiotic GO:0043353: enucleate erythrocyte differentiation GO:0003684: damaged DNA binding GO:0051208: sequestering of calcium ion GO:0051087: chaperone binding GO:0003887: DNA-directed DNA polymerase activity GO:0043218: compact myelin GO:0043033: isoamylase complex GO:0045947: negative regulation of translational initiation GO:0000387: spliceosomal snRNP biogenesis GO:0047021: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity GO:0005126: hematopoietin/interferon-class (D200-domain) cytokine receptor binding GO:0008299: isoprenoid biosynthetic process GO:0045239: tricarboxylic acid cycle enzyme complex GO:0020027: hemoglobin metabolic process GO:0030534: adult behavior GO:0002687: positive regulation of leukocyte migration GO:0042921: glucocorticoid receptor signaling pathway GO:0016251: general RNA polymerase II transcription factor activity GO:0008137: NADH dehydrogenase (ubiquinone) activity GO:0000380: alternative nuclear mRNA splicing, via spliceosome GO:0065002: intracellular protein transmembrane transport GO:0003706: ligand-regulated transcription factor activity GO:0019789: SUMO ligase activity GO:0019682: glyceraldehyde-3-phosphate metabolic process GO:0004521: endoribonuclease activity GO:0046854: phosphoinositide phosphorylation GO:0004921: interleukin-11 receptor activity GO:0016531: copper chaperone activity GO:0031403: lithium ion binding GO:0006924: activation-induced cell death of T cells GO:0047750: cholestenol delta-isomerase activity GO:0019209: kinase activator activity GO:0022625: cytosolic large ribosomal subunit GO:0032364: oxygen homeostasis GO:0046326: positive regulation of glucose import GO:0060052: neurofilament cytoskeleton organization GO:0043249: erythrocyte maturation GO:0004135: amylo-alpha-1,6-glucosidase activity GO:0008599: protein phosphatase type 1 regulator activity GO:0042552: myelination GO:0001932: regulation of protein amino acid phosphorylation GO:0016878: acid-thiol ligase activity GO:0055010: ventricular cardiac muscle morphogenesis GO:0002821: positive regulation of adaptive immune response GO:0060072: large conductance calcium-activated potassium channel activity GO:0005669: transcription factor TFIID complex GO:0001892: embryonic placenta development GO:0015721: bile acid and bile salt transport GO:0005784: translocon complex GO:0030641: regulation of cellular pH GO:0042759: long-chain fatty acid biosynthetic process GO:0001952: regulation of cell-matrix adhesion GO:0051920: peroxiredoxin activity GO:0006800: oxygen and reactive oxygen species metabolic process GO:0050221: prostaglandin-E2 9-reductase activity GO:0004526: ribonuclease P activity GO:0042769: DNA damage response, detection of DNA damage GO:0043039: tRNA aminoacylation GO:0030169: low-density lipoprotein binding GO:0007213: muscarinic acetylcholine receptor signaling pathway GO:0030371: translation repressor activity GO:0042541: hemoglobin biosynthetic process GO:0016081: synaptic vesicle docking during exocytosis GO:0004300: enoyl-CoA hydratase activity GO:0051318: G1 phase GO:0004634: phosphopyruvate hydratase activity GO:0004576: oligosaccharyl transferase activity GO:0004161: dimethylallyltranstransferase activity GO:0006301: postreplication repair GO:0005977: glycogen metabolic process GO:0003923: GPI-anchor transamidase activity GO:0042719: mitochondrial intermembrane space protein transporter complex GO:0005372: water transporter activity GO:0005853: eukaryotic translation elongation factor 1 complex GO:0006654: phosphatidic acid biosynthetic process GO:0033081: regulation of T cell differentiation in the thymus GO:0004064: arylesterase activity GO:0042835: BRE binding GO:0000827: inositol 1,3,4,5,6-pentakisphosphate kinase activity GO:0008324: cation transmembrane transporter activity GO:0006221: pyrimidine nucleotide biosynthetic process GO:0060088: auditory receptor cell stereocilium organization GO:0008333: endosome to lysosome transport GO:0006082: organic acid metabolic process GO:0007309: oocyte axis specification GO:0004769: steroid delta-isomerase activity GO:0006984: ER-nuclear signaling pathway GO:0031401: positive regulation of protein modification process GO:0006309: DNA fragmentation during apoptosis GO:0004924: oncostatin-M receptor activity GO:0004740: pyruvate dehydrogenase (acetyl-transferring) kinase activity GO:0043162: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0004058: aromatic-L-amino-acid decarboxylase activity GO:0000381: regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000015: phosphopyruvate hydratase complex GO:0003988: acetyl-CoA C-acyltransferase activity GO:0016254: preassembly of GPI anchor in ER membrane GO:0000389: nuclear mRNA 3'-splice site recognition GO:0032259: methylation GO:0004159: dihydrouracil dehydrogenase (NAD+) activity GO:0045738: negative regulation of DNA repair GO:0051262: protein tetramerization GO:0000210: NAD+ diphosphatase activity GO:0000781: chromosome, telomeric region GO:0006518: peptide metabolic process GO:0004137: deoxycytidine kinase activity GO:0006011: UDP-glucose metabolic process GO:0033814: propanoyl-CoA C-acyltransferase activity GO:0005072: transforming growth factor beta receptor, cytoplasmic mediator activity GO:0006789: bilirubin conjugation GO:0006529: asparagine biosynthetic process GO:0031508: centromeric heterochromatin formation GO:0031119: tRNA pseudouridine synthesis GO:0031032: actomyosin structure organization GO:0008121: ubiquinol-cytochrome-c reductase activity GO:0001844: protein insertion into mitochondrial membrane during induction of apoptosis GO:0006777: Mo-molybdopterin cofactor biosynthetic process GO:0010768: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0000105: histidine biosynthetic process GO:0006120: mitochondrial electron transport, NADH to ubiquinone GO:0005732: small nucleolar ribonucleoprotein complex GO:0019226: transmission of nerve impulse GO:0005086: ARF guanyl-nucleotide exchange factor activity GO:0019089: transmission of virus GO:0032236: positive regulation of calcium ion transport via store-operated calcium channel activity GO:0004096: catalase activity GO:0004470: malic enzyme activity GO:0051541: elastin metabolic process GO:0046685: response to arsenic GO:0045926: negative regulation of growth GO:0006467: protein thiol-disulfide exchange GO:0060083: smooth muscle contraction involved in micturition GO:0004691: cAMP-dependent protein kinase activity GO:0010613: positive regulation of cardiac muscle hypertrophy GO:0016219: GDP-dissociation stimulator activity GO:0004715: non-membrane spanning protein tyrosine kinase activity GO:0042809: vitamin D receptor binding GO:0055009: atrial cardiac muscle morphogenesis GO:0032790: ribosome disassembly GO:0015917: aminophospholipid transport GO:0008633: activation of pro-apoptotic gene products GO:0019276: UDP-N-acetylgalactosamine metabolic process GO:0043550: regulation of lipid kinase activity GO:0032862: activation of Rho GTPase activity GO:0000900: translation repressor activity, nucleic acid binding GO:0008180: signalosome GO:0070063: RNA polymerase binding GO:0003746: translation elongation factor activity GO:0001514: selenocysteine incorporation GO:0033014: tetrapyrrole biosynthetic process GO:0015321: sodium-dependent phosphate transmembrane transporter activity GO:0050847: progesterone receptor signaling pathway GO:0031674: I band GO:0016018: cyclosporin A binding GO:0004784: superoxide dismutase activity GO:0019059: initiation of viral infection GO:0008536: Ran GTPase binding GO:0010458: exit from mitosis GO:0005112: Notch binding GO:0008641: small protein activating enzyme activity GO:0046755: non-lytic virus budding GO:0006710: androgen catabolic process GO:0000049: tRNA binding GO:0005850: eukaryotic translation initiation factor 2 complex GO:0005138: interleukin-6 receptor binding GO:0050819: negative regulation of coagulation GO:0004590: orotidine-5'-phosphate decarboxylase activity GO:0017076: purine nucleotide binding GO:0006418: tRNA aminoacylation for protein translation GO:0002675: positive regulation of acute inflammatory response GO:0009249: protein lipoylation GO:0030203: glycosaminoglycan metabolic process GO:0060166: olfactory pit development GO:0004598: peptidylamidoglycolate lyase activity GO:0004647: phosphoserine phosphatase activity GO:0007220: Notch receptor processing GO:0047115: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity GO:0015991: ATP hydrolysis coupled proton transport GO:0045453: bone resorption GO:0006520: amino acid metabolic process GO:0001887: selenium metabolic process GO:0006471: protein amino acid ADP-ribosylation GO:0033857: diphosphoinositol-pentakisphosphate kinase activity GO:0048806: genitalia development GO:0004915: interleukin-6 receptor activity GO:0006106: fumarate metabolic process GO:0004861: cyclin-dependent protein kinase inhibitor activity GO:0051877: pigment granule aggregation in cell center GO:0046716: muscle maintenance GO:0004563: beta-N-acetylhexosaminidase activity GO:0000178: exosome (RNase complex) GO:0045931: positive regulation of mitotic cell cycle GO:0047804: cysteine-S-conjugate beta-lyase activity GO:0001934: positive regulation of protein amino acid phosphorylation GO:0006434: seryl-tRNA aminoacylation GO:0019871: sodium channel inhibitor activity GO:0047006: 20-alpha-hydroxysteroid dehydrogenase activity GO:0000832: inositol hexakisphosphate 5-kinase activity GO:0019752: carboxylic acid metabolic process GO:0000077: DNA damage checkpoint GO:0005498: sterol carrier activity GO:0045116: protein neddylation GO:0016407: acetyltransferase activity GO:0008831: dTDP-4-dehydrorhamnose reductase activity GO:0009982: pseudouridine synthase activity GO:0001757: somite specification GO:0033989: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity GO:0019787: small conjugating protein ligase activity GO:0000027: ribosomal large subunit assembly GO:0006110: regulation of glycolysis GO:0009165: nucleotide biosynthetic process GO:0015934: large ribosomal subunit GO:0033044: regulation of chromosome organization GO:0001888: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0043024: ribosomal small subunit binding GO:0051716: cellular response to stimulus GO:0032020: ISG15-protein conjugation GO:0004333: fumarate hydratase activity GO:0015077: monovalent inorganic cation transmembrane transporter activity GO:0006730: one-carbon compound metabolic process GO:0004556: alpha-amylase activity GO:0006778: porphyrin metabolic process GO:0017119: Golgi transport complex GO:0004190: aspartic-type endopeptidase activity GO:0046886: positive regulation of hormone biosynthetic process GO:0003874: 6-pyruvoyltetrahydropterin synthase activity GO:0004981: muscarinic acetylcholine receptor activity GO:0031118: rRNA pseudouridine synthesis GO:0006689: ganglioside catabolic process GO:0034263: autophagy in response to ER overload GO:0055007: cardiac muscle cell differentiation GO:0003743: translation initiation factor activity GO:0031698: beta-2 adrenergic receptor binding GO:0008441: 3'(2'),5'-bisphosphate nucleotidase activity GO:0008652: amino acid biosynthetic process GO:0031575: G1/S transition checkpoint GO:0031362: anchored to external side of plasma membrane GO:0000279: M phase GO:0042780: tRNA 3'-end processing GO:0051000: positive regulation of nitric-oxide synthase activity GO:0004843: ubiquitin-specific protease activity GO:0016773: phosphotransferase activity, alcohol group as acceptor GO:0006583: melanin biosynthetic process from tyrosine GO:0005678: chromatin assembly complex GO:0006970: response to osmotic stress GO:0043666: regulation of phosphoprotein phosphatase activity GO:0042787: protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0008389: coumarin 7-hydroxylase activity GO:0004105: choline-phosphate cytidylyltransferase activity GO:0043015: gamma-tubulin binding GO:0043560: insulin receptor substrate binding GO:0005751: mitochondrial respiratory chain complex IV GO:0004581: dolichyl-phosphate beta-glucosyltransferase activity GO:0008250: oligosaccharyltransferase complex GO:0000276: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) GO:0032473: external side of mitochondrial outer membrane GO:0048547: gut morphogenesis GO:0005010: insulin-like growth factor receptor activity GO:0008889: glycerophosphodiester phosphodiesterase activity GO:0015020: glucuronosyltransferase activity GO:0004132: dCMP deaminase activity GO:0032344: regulation of aldosterone metabolic process GO:0043297: apical junction assembly GO:0007184: SMAD protein nuclear translocation GO:0005534: galactose binding GO:0045039: protein import into mitochondrial inner membrane GO:0005153: interleukin-8 receptor binding GO:0016255: attachment of GPI anchor to protein GO:0004969: histamine receptor activity GO:0000307: cyclin-dependent protein kinase holoenzyme complex GO:0042171: lysophosphatidic acid acyltransferase activity GO:0004485: methylcrotonoyl-CoA carboxylase activity GO:0033180: proton-transporting V-type ATPase, V1 domain GO:0016494: C-X-C chemokine receptor activity GO:0004970: ionotropic glutamate receptor activity GO:0015446: arsenite transmembrane-transporting ATPase activity GO:0002009: morphogenesis of an epithelium GO:0004948: calcitonin receptor activity GO:0033269: internode region of axon GO:0009841: mitochondrial endopeptidase Clp complex GO:0005246: calcium channel regulator activity GO:0005686: snRNP U2 GO:0042765: GPI-anchor transamidase complex GO:0008634: negative regulation of survival gene product expression GO:0035248: alpha-1,4-N-acetylgalactosaminyltransferase activity GO:0005068: transmembrane receptor protein tyrosine kinase adaptor protein activity GO:0046839: phospholipid dephosphorylation GO:0008157: protein phosphatase 1 binding GO:0005753: mitochondrial proton-transporting ATP synthase complex GO:0042771: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0000792: heterochromatin GO:0017101: aminoacyl-tRNA synthetase multienzyme complex GO:0030586: [methionine synthase] reductase activity GO:0045837: negative regulation of membrane potential GO:0001573: ganglioside metabolic process GO:0051028: mRNA transport GO:0005579: membrane attack complex GO:0006626: protein targeting to mitochondrion GO:0008206: bile acid metabolic process GO:0004865: protein serine/threonine phosphatase inhibitor activity GO:0000398: nuclear mRNA splicing, via spliceosome GO:0021537: telencephalon development GO:0008049: male courtship behavior GO:0060081: membrane hyperpolarization GO:0006556: S-adenosylmethionine biosynthetic process GO:0015319: sodium:inorganic phosphate symporter activity GO:0006744: ubiquinone biosynthetic process GO:0021554: optic nerve development GO:0006400: tRNA modification GO:0032767: copper-dependent protein binding GO:0032467: positive regulation of cytokinesis GO:0051536: iron-sulfur cluster binding GO:0000386: second spliceosomal transesterification activity GO:0006790: sulfur metabolic process GO:0048675: axon extension GO:0006104: succinyl-CoA metabolic process GO:0000070: mitotic sister chromatid segregation GO:0012506: vesicle membrane GO:0019885: antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0042587: glycogen granule GO:0003823: antigen binding GO:0035267: NuA4 histone acetyltransferase complex GO:0007158: neuron adhesion GO:0030299: cholesterol absorption GO:0004012: phospholipid-translocating ATPase activity GO:0007281: germ cell development GO:0042296: ISG15 ligase activity GO:0048270: methionine adenosyltransferase regulator activity GO:0007400: neuroblast fate determination GO:0051881: regulation of mitochondrial membrane potential GO:0019992: diacylglycerol binding GO:0030001: metal ion transport GO:0002763: positive regulation of myeloid leukocyte differentiation GO:0000272: polysaccharide catabolic process GO:0050816: phosphothreonine binding GO:0009060: aerobic respiration GO:0007157: heterophilic cell adhesion GO:0006552: leucine catabolic process GO:0005487: nucleocytoplasmic transporter activity GO:0045668: negative regulation of osteoblast differentiation GO:0045010: actin nucleation GO:0042776: mitochondrial ATP synthesis coupled proton transport GO:0004477: methenyltetrahydrofolate cyclohydrolase activity GO:0051823: regulation of synapse structural plasticity GO:0060165: regulation of timing of subpallium neuron differentiation GO:0005900: oncostatin-M receptor complex GO:0045651: positive regulation of macrophage differentiation GO:0042221: response to chemical stimulus GO:0006360: transcription from RNA polymerase I promoter GO:0021779: oligodendrocyte cell fate commitment GO:0035173: histone kinase activity GO:0004066: asparagine synthase (glutamine-hydrolyzing) activity GO:0001516: prostaglandin biosynthetic process GO:0009396: folic acid and derivative biosynthetic process GO:0016409: palmitoyltransferase activity GO:0004311: farnesyltranstransferase activity GO:0032446: protein modification by small protein conjugation GO:0016272: prefoldin complex GO:0006020: inositol metabolic process GO:0003755: peptidyl-prolyl cis-trans isomerase activity GO:0043183: vascular endothelial growth factor receptor 1 binding GO:0018106: peptidyl-histidine phosphorylation GO:0005672: transcription factor TFIIA complex GO:0045226: extracellular polysaccharide biosynthetic process GO:0006401: RNA catabolic process GO:0006098: pentose-phosphate shunt GO:0004372: glycine hydroxymethyltransferase activity GO:0008033: tRNA processing GO:0000184: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0007193: inhibition of adenylate cyclase activity by G-protein signaling GO:0016706: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0005663: DNA replication factor C complex GO:0048147: negative regulation of fibroblast proliferation GO:0033178: proton-transporting two-sector ATPase complex, catalytic domain GO:0031323: regulation of cellular metabolic process GO:0030628: pre-mRNA 3'-splice site binding GO:0005947: mitochondrial alpha-ketoglutarate dehydrogenase complex GO:0045930: negative regulation of mitotic cell cycle GO:0008235: metalloexopeptidase activity GO:0008047: enzyme activator activity GO:0046966: thyroid hormone receptor binding GO:0000120: RNA polymerase I transcription factor complex GO:0006611: protein export from nucleus GO:0004830: tryptophan-tRNA ligase activity GO:0005674: transcription factor TFIIF complex GO:0005655: nucleolar ribonuclease P complex GO:0050790: regulation of catalytic activity GO:0004129: cytochrome-c oxidase activity GO:0004331: fructose-2,6-bisphosphate 2-phosphatase activity GO:0006265: DNA topological change GO:0060082: eye blink reflex GO:0030218: erythrocyte differentiation GO:0032391: photoreceptor connecting cilium GO:0035110: leg morphogenesis GO:0001669: acrosome GO:0016458: gene silencing GO:0030433: ER-associated protein catabolic process GO:0046541: saliva secretion GO:0004810: tRNA adenylyltransferase activity GO:0004060: arylamine N-acetyltransferase activity GO:0032402: melanosome transport GO:0003918: DNA topoisomerase (ATP-hydrolyzing) activity GO:0000038: very-long-chain fatty acid metabolic process GO:0060047: heart contraction GO:0009405: pathogenesis GO:0044445: cytosolic part GO:0006089: lactate metabolic process GO:0004588: orotate phosphoribosyltransferase activity GO:0003870: 5-aminolevulinate synthase activity GO:0004090: carbonyl reductase (NADPH) activity GO:0032027: myosin light chain binding GO:0015270: dihydropyridine-sensitive calcium channel activity GO:0002248: connective tissue replacement during inflammatory response GO:0048496: maintenance of organ identity GO:0007206: activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway GO:0050220: prostaglandin-E synthase activity GO:0015986: ATP synthesis coupled proton transport GO:0006878: cellular copper ion homeostasis GO:0003844: 1,4-alpha-glucan branching enzyme activity GO:0045582: positive regulation of T cell differentiation GO:0016805: dipeptidase activity GO:0015105: arsenite transmembrane transporter activity GO:0004597: peptide-aspartate beta-dioxygenase activity GO:0004063: aryldialkylphosphatase activity GO:0016769: transferase activity, transferring nitrogenous groups GO:0050658: RNA transport GO:0042554: superoxide release GO:0008593: regulation of Notch signaling pathway GO:0010259: multicellular organismal aging GO:0030317: sperm motility GO:0046034: ATP metabolic process GO:0018738: S-formylglutathione hydrolase activity GO:0004923: leukemia inhibitory factor receptor activity GO:0000245: spliceosome assembly GO:0004823: leucine-tRNA ligase activity GO:0042826: histone deacetylase binding GO:0004033: aldo-keto reductase activity GO:0046824: positive regulation of nucleocytoplasmic transport GO:0005890: sodium:potassium-exchanging ATPase complex GO:0000059: protein import into nucleus, docking GO:0006474: N-terminal protein amino acid acetylation GO:0008080: N-acetyltransferase activity GO:0004423: iduronate-2-sulfatase activity GO:0032012: regulation of ARF protein signal transduction GO:0042137: sequestering of neurotransmitter GO:0001786: phosphatidylserine binding GO:0005896: interleukin-6 receptor complex GO:0002026: regulation of the force of heart contraction GO:0051044: positive regulation of membrane protein ectodomain proteolysis GO:0015677: copper ion import GO:0045509: interleukin-27 receptor activity GO:0006275: regulation of DNA replication GO:0009399: nitrogen fixation GO:0004303: estradiol 17-beta-dehydrogenase activity GO:0006687: glycosphingolipid metabolic process GO:0004618: phosphoglycerate kinase activity GO:0040016: embryonic cleavage GO:0007127: meiosis I GO:0033981: D-dopachrome decarboxylase activity GO:0045541: negative regulation of cholesterol biosynthetic process GO:0004298: threonine-type endopeptidase activity GO:0005031: tumor necrosis factor receptor activity GO:0045444: fat cell differentiation GO:0032088: negative regulation of NF-kappaB transcription factor activity GO:0006449: regulation of translational termination GO:0046619: optic placode formation involved in camera-type eye GO:0006610: ribosomal protein import into nucleus GO:0003689: DNA clamp loader activity GO:0045263: proton-transporting ATP synthase complex, coupling factor F(o) GO:0004807: triose-phosphate isomerase activity GO:0004831: tyrosine-tRNA ligase activity GO:0006200: ATP catabolic process GO:0016998: cell wall catabolic process GO:0006729: tetrahydrobiopterin biosynthetic process GO:0000153: cytoplasmic ubiquitin ligase complex GO:0007608: sensory perception of smell GO:0006429: leucyl-tRNA aminoacylation GO:0046579: positive regulation of Ras protein signal transduction GO:0021530: spinal cord oligodendrocyte cell fate specification GO:0006622: protein targeting to lysosome GO:0043619: regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0016212: kynurenine-oxoglutarate transaminase activity GO:0016149: translation release factor activity, codon specific GO:0003720: telomerase activity GO:0034465: response to carbon monoxide GO:0007243: protein kinase cascade GO:0005673: transcription factor TFIIE complex GO:0015238: drug transporter activity GO:0006436: tryptophanyl-tRNA aminoacylation GO:0000175: 3'-5'-exoribonuclease activity GO:0015074: DNA integration GO:0030007: cellular potassium ion homeostasis GO:0031307: integral to mitochondrial outer membrane GO:0031672: A band GO:0001819: positive regulation of cytokine production GO:0006446: regulation of translational initiation GO:0016198: axon choice point recognition GO:0010001: glial cell differentiation GO:0003995: acyl-CoA dehydrogenase activity GO:0008038: neuron recognition GO:0004003: ATP-dependent DNA helicase activity GO:0042446: hormone biosynthetic process GO:0019829: cation-transporting ATPase activity GO:0046949: acyl-CoA biosynthetic process GO:0003701: RNA polymerase I transcription factor activity GO:0030529: ribonucleoprotein complex GO:0016226: iron-sulfur cluster assembly GO:0022010: myelination in the central nervous system GO:0004776: succinate-CoA ligase (GDP-forming) activity GO:0031252: cell leading edge GO:0004428: inositol or phosphatidylinositol kinase activity GO:0007292: female gamete generation GO:0004998: transferrin receptor activity GO:0030041: actin filament polymerization GO:0006437: tyrosyl-tRNA aminoacylation GO:0004164: diphthine synthase activity GO:0003678: DNA helicase activity GO:0005747: mitochondrial respiratory chain complex I GO:0004167: dopachrome isomerase activity GO:0006325: establishment or maintenance of chromatin architecture GO:0016303: 1-phosphatidylinositol-3-kinase activity GO:0016281: eukaryotic translation initiation factor 4F complex GO:0016810: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0030240: muscle thin filament assembly GO:0031202: RNA splicing factor activity, transesterification mechanism GO:0043022: ribosome binding GO:0045821: positive regulation of glycolysis GO:0048102: autophagic cell death GO:0006487: protein amino acid N-linked glycosylation GO:0034235: GPI anchor binding GO:0030983: mismatched DNA binding GO:0007017: microtubule-based process GO:0045730: respiratory burst GO:0019538: protein metabolic process GO:0042404: thyroid hormone catabolic process GO:0019048: virus-host interaction GO:0006942: regulation of striated muscle contraction GO:0009628: response to abiotic stimulus GO:0042149: cellular response to glucose starvation GO:0031405: lipoic acid binding GO:0003883: CTP synthase activity GO:0042623: ATPase activity, coupled GO:0005697: telomerase holoenzyme complex GO:0003857: 3-hydroxyacyl-CoA dehydrogenase activity GO:0050576: 3-keto-steroid reductase activity GO:0016818: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0021527: spinal cord association neuron differentiation GO:0006419: alanyl-tRNA aminoacylation #1083IR 51 GO:0015194: L-serine transmembrane transporter activity GO:0033596: TSC1-TSC2 complex GO:0047131: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity GO:0015184: L-cystine transmembrane transporter activity GO:0015195: L-threonine transmembrane transporter activity GO:0034590: L-hydroxyproline transmembrane transporter activity GO:0015193: L-proline transmembrane transporter activity GO:0050957: equilibrioception GO:0008392: arachidonic acid epoxygenase activity GO:0034597: phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity GO:0005883: neurofilament GO:0006166: purine ribonucleoside salvage GO:0008090: retrograde axon cargo transport GO:0008143: poly(A) binding GO:0004422: hypoxanthine phosphoribosyltransferase activity GO:0015824: proline transport GO:0015825: L-serine transport GO:0008266: poly(U) binding GO:0016814: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0046847: filopodium formation GO:0033693: neurofilament bundle assembly GO:0030201: heparan sulfate proteoglycan metabolic process GO:0031616: spindle pole centrosome GO:0003835: beta-galactoside alpha-2,6-sialyltransferase activity GO:0030516: regulation of axon extension GO:0046907: intracellular transport GO:0031223: auditory behavior GO:0000800: lateral element GO:0007098: centrosome cycle GO:0030506: ankyrin binding GO:0006913: nucleocytoplasmic transport GO:0001750: photoreceptor outer segment GO:0045162: clustering of voltage-gated sodium channels GO:0007130: synaptonemal complex assembly GO:0015826: threonine transport GO:0006536: glutamate metabolic process GO:0006996: organelle organization GO:0015811: L-cystine transport GO:0000940: outer kinetochore of condensed chromosome GO:0004926: non-G-protein coupled 7TM receptor activity GO:0007143: female meiosis GO:0005267: potassium channel activity GO:0010226: response to lithium ion GO:0010826: negative regulation of centrosome duplication GO:0005844: polysome GO:0050750: low-density lipoprotein receptor binding GO:0004971: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:0034589: hydroxyproline transport GO:0048667: cell morphogenesis involved in neuron differentiation GO:0005041: low-density lipoprotein receptor activity GO:0004908: interleukin-1 receptor activity #1051IR 38 GO:0006891: intra-Golgi vesicle-mediated transport GO:0045104: intermediate filament cytoskeleton organization GO:0005523: tropomyosin binding GO:0002891: positive regulation of immunoglobulin mediated immune response GO:0014731: spectrin-associated cytoskeleton GO:0006893: Golgi to plasma membrane transport GO:0031256: leading edge membrane GO:0015327: cystine:glutamate antiporter activity GO:0045055: regulated secretory pathway GO:0030507: spectrin binding GO:0042462: eye photoreceptor cell development GO:0030239: myofibril assembly GO:0004435: phosphoinositide phospholipase C activity GO:0005496: steroid binding GO:0000156: two-component response regulator activity GO:0008091: spectrin GO:0060084: synaptic transmission involved in micturition GO:0010839: negative regulation of keratinocyte proliferation GO:0030016: myofibril GO:0007352: zygotic determination of dorsal/ventral axis GO:0019215: intermediate filament binding GO:0030259: lipid glycosylation GO:0033005: positive regulation of mast cell activation GO:0016180: snRNA processing GO:0005577: fibrinogen complex GO:0016235: aggresome GO:0032039: integrator complex GO:0035095: behavioral response to nicotine GO:0006198: cAMP catabolic process GO:0030140: trans-Golgi network transport vesicle GO:0005024: transforming growth factor beta receptor activity GO:0000160: two-component signal transduction system (phosphorelay) GO:0060053: neurofilament cytoskeleton GO:0060369: positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0046488: phosphatidylinositol metabolic process GO:0048812: neurite morphogenesis GO:0048041: focal adhesion formation GO:0002860: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target #1063IR 694 GO:0009100: glycoprotein metabolic process GO:0034446: substrate adhesion-dependent cell spreading GO:0001921: positive regulation of receptor recycling GO:0043067: regulation of programmed cell death GO:0051707: response to other organism GO:0008652: cellular amino acid biosynthetic process GO:0001702: gastrulation with mouth forming second GO:0070244: negative regulation of thymocyte apoptosis GO:0007631: feeding behavior GO:0002001: renin secretion into blood stream GO:0046111: xanthine biosynthetic process GO:0019229: regulation of vasoconstriction GO:0044430: cytoskeletal part GO:0000724: double-strand break repair via homologous recombination GO:0035385: Roundabout signaling pathway GO:0008589: regulation of smoothened signaling pathway GO:0005451: monovalent cation:hydrogen antiporter activity GO:0019863: IgE binding GO:0019067: viral assembly, maturation, egress, and release GO:0042581: specific granule GO:0009267: cellular response to starvation GO:0030169: low-density lipoprotein particle binding GO:0001932: regulation of protein phosphorylation GO:0060347: heart trabecula formation GO:0009258: 10-formyltetrahydrofolate catabolic process GO:0090024: negative regulation of neutrophil chemotaxis GO:0060512: prostate gland morphogenesis GO:0042588: zymogen granule GO:0006270: DNA-dependent DNA replication initiation GO:0060421: positive regulation of heart growth GO:0007129: synapsis GO:0007249: I-kappaB kinase/NF-kappaB cascade GO:0015879: carnitine transport GO:0007263: nitric oxide mediated signal transduction GO:0043518: negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0034188: apolipoprotein A-I receptor activity GO:0034371: chylomicron remodeling GO:0009743: response to carbohydrate stimulus GO:0042405: nuclear inclusion body GO:0031663: lipopolysaccharide-mediated signaling pathway GO:0006379: mRNA cleavage GO:0016064: immunoglobulin mediated immune response GO:0035329: hippo signaling cascade GO:0002314: germinal center B cell differentiation GO:0001946: lymphangiogenesis GO:0071333: cellular response to glucose stimulus GO:0090103: cochlea morphogenesis GO:0045071: negative regulation of viral genome replication GO:0032494: response to peptidoglycan GO:0050772: positive regulation of axonogenesis GO:0019894: kinesin binding GO:0000123: histone acetyltransferase complex GO:0021510: spinal cord development GO:0035602: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow GO:0051930: regulation of sensory perception of pain GO:0046950: cellular ketone body metabolic process GO:0015174: basic amino acid transmembrane transporter activity GO:0002790: peptide secretion GO:0022008: neurogenesis GO:0000299: integral to membrane of membrane fraction GO:0050925: negative regulation of negative chemotaxis GO:0060527: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0030837: negative regulation of actin filament polymerization GO:0030676: Rac guanyl-nucleotide exchange factor activity GO:0040017: positive regulation of locomotion GO:0071385: cellular response to glucocorticoid stimulus GO:0035024: negative regulation of Rho protein signal transduction GO:0060412: ventricular septum morphogenesis GO:0016594: glycine binding GO:0050999: regulation of nitric-oxide synthase activity GO:0070141: response to UV-A GO:0009888: tissue development GO:0046696: lipopolysaccharide receptor complex GO:0060169: negative regulation of adenosine receptor signaling pathway GO:0007501: mesodermal cell fate specification GO:0035235: ionotropic glutamate receptor signaling pathway GO:0043046: DNA methylation involved in gamete generation GO:0008331: high voltage-gated calcium channel activity GO:0006497: protein lipidation GO:0043129: surfactant homeostasis GO:0021769: orbitofrontal cortex development GO:0046697: decidualization GO:0004123: cystathionine gamma-lyase activity GO:0015038: glutathione disulfide oxidoreductase activity GO:0042165: neurotransmitter binding GO:0048562: embryonic organ morphogenesis GO:0000062: fatty-acyl-CoA binding GO:0034752: cytosolic aryl hydrocarbon receptor complex GO:0033280: response to vitamin D GO:0045130: keratan sulfotransferase activity GO:0050727: regulation of inflammatory response GO:0004117: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity GO:0051168: nuclear export GO:0060501: positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0051225: spindle assembly GO:0060688: regulation of morphogenesis of a branching structure GO:0033691: sialic acid binding GO:0005283: sodium:amino acid symporter activity GO:0060024: rhythmic synaptic transmission GO:0034361: very-low-density lipoprotein particle GO:0070189: kynurenine metabolic process GO:0001954: positive regulation of cell-matrix adhesion GO:0001505: regulation of neurotransmitter levels GO:0016199: axon midline choice point recognition GO:0001931: uropod GO:0004500: dopamine beta-monooxygenase activity GO:0045502: dynein binding GO:0070814: hydrogen sulfide biosynthetic process GO:0047273: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity GO:0060687: regulation of branching involved in prostate gland morphogenesis GO:2000124: regulation of endocannabinoid signaling pathway GO:0008489: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity GO:0042135: neurotransmitter catabolic process GO:0046875: ephrin receptor binding GO:0008611: ether lipid biosynthetic process GO:0045907: positive regulation of vasoconstriction GO:0030544: Hsp70 protein binding GO:0046103: inosine biosynthetic process GO:0005776: autophagic vacuole GO:0009880: embryonic pattern specification GO:0045187: regulation of circadian sleep/wake cycle, sleep GO:0045190: isotype switching GO:0051497: negative regulation of stress fiber assembly GO:0032455: nerve growth factor processing GO:0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0003149: membranous septum morphogenesis GO:0001553: luteinization GO:0051041: positive regulation of calcium-independent cell-cell adhesion GO:0070493: thrombin receptor signaling pathway GO:0050667: homocysteine metabolic process GO:0010744: positive regulation of macrophage derived foam cell differentiation GO:0042339: keratan sulfate metabolic process GO:0032902: nerve growth factor production GO:0004601: peroxidase activity GO:0000722: telomere maintenance via recombination GO:0050613: delta14-sterol reductase activity GO:0000038: very long-chain fatty acid metabolic process GO:0006534: cysteine metabolic process GO:0050880: regulation of blood vessel size GO:0022028: tangential migration from the subventricular zone to the olfactory bulb GO:0052547: regulation of peptidase activity GO:0045899: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045806: negative regulation of endocytosis GO:0071222: cellular response to lipopolysaccharide GO:0016601: Rac protein signal transduction GO:0003986: acetyl-CoA hydrolase activity GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0048406: nerve growth factor binding GO:0031982: vesicle GO:0030277: maintenance of gastrointestinal epithelium GO:0048185: activin binding GO:0005976: polysaccharide metabolic process GO:0001875: lipopolysaccharide receptor activity GO:0060907: positive regulation of macrophage cytokine production GO:0016585: chromatin remodeling complex GO:0021847: ventricular zone neuroblast division GO:0009605: response to external stimulus GO:0048244: phytanoyl-CoA dioxygenase activity GO:0001518: voltage-gated sodium channel complex GO:0032507: maintenance of protein location in cell GO:0080146: L-cysteine desulfhydrase activity GO:0021696: cerebellar cortex morphogenesis GO:0055010: ventricular cardiac muscle tissue morphogenesis GO:0001741: XY body GO:0031749: D2 dopamine receptor binding GO:0048853: forebrain morphogenesis GO:0060203: clathrin sculpted glutamate transport vesicle membrane GO:0051925: regulation of calcium ion transport via voltage-gated calcium channel activity GO:0060059: embryonic retina morphogenesis in camera-type eye GO:0033688: regulation of osteoblast proliferation GO:0001662: behavioral fear response GO:0060836: lymphatic endothelial cell differentiation GO:0032589: neuron projection membrane GO:0034374: low-density lipoprotein particle remodeling GO:0046101: hypoxanthine biosynthetic process GO:0003326: pancreatic A cell fate commitment GO:0000188: inactivation of MAPK activity GO:0071504: cellular response to heparin GO:0034587: piRNA metabolic process GO:0061364: apoptosis involved in luteolysis GO:0004602: glutathione peroxidase activity GO:0002636: positive regulation of germinal center formation GO:0017059: serine C-palmitoyltransferase complex GO:0045335: phagocytic vesicle GO:0043395: heparan sulfate proteoglycan binding GO:0043621: protein self-association GO:0048554: positive regulation of metalloenzyme activity GO:0034185: apolipoprotein binding GO:0034046: poly(G) RNA binding GO:0051963: regulation of synaptogenesis GO:0021520: spinal cord motor neuron cell fate specification GO:0043522: leucine zipper domain binding GO:0015485: cholesterol binding GO:0007423: sensory organ development GO:0050910: detection of mechanical stimulus involved in sensory perception of sound GO:0003350: pulmonary myocardium development GO:0016236: macroautophagy GO:0006637: acyl-CoA metabolic process GO:0034109: homotypic cell-cell adhesion GO:0045750: positive regulation of S phase of mitotic cell cycle GO:0016772: transferase activity, transferring phosphorus-containing groups GO:0071672: negative regulation of smooth muscle cell chemotaxis GO:0030857: negative regulation of epithelial cell differentiation GO:0030240: skeletal muscle thin filament assembly GO:0004321: fatty-acyl-CoA synthase activity GO:0033631: cell-cell adhesion mediated by integrin GO:0051973: positive regulation of telomerase activity GO:0019369: arachidonic acid metabolic process GO:0042392: sphingosine-1-phosphate phosphatase activity GO:0006848: pyruvate transport GO:0048013: ephrin receptor signaling pathway GO:0043083: synaptic cleft GO:0001964: startle response GO:0010035: response to inorganic substance GO:0031513: nonmotile primary cilium GO:0048565: digestive tract development GO:0046777: protein autophosphorylation GO:0043616: keratinocyte proliferation GO:0035265: organ growth GO:0055074: calcium ion homeostasis GO:0060595: fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0071229: cellular response to acid GO:0030285: integral to synaptic vesicle membrane GO:0032488: Cdc42 protein signal transduction GO:0006471: protein ADP-ribosylation GO:0005006: epidermal growth factor receptor activity GO:0030323: respiratory tube development GO:0005548: phospholipid transporter activity GO:0060667: branch elongation involved in salivary gland morphogenesis GO:0008273: calcium, potassium:sodium antiporter activity GO:0048791: calcium ion-dependent exocytosis of neurotransmitter GO:0004441: inositol-1,4-bisphosphate 1-phosphatase activity GO:0061001: regulation of dendritic spine morphogenesis GO:0019217: regulation of fatty acid metabolic process GO:0030675: Rac GTPase activator activity GO:0003847: 1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0048268: clathrin coat assembly GO:0010942: positive regulation of cell death GO:0060414: aorta smooth muscle tissue morphogenesis GO:0035604: fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow GO:0045987: positive regulation of smooth muscle contraction GO:0004522: pancreatic ribonuclease activity GO:0008046: axon guidance receptor activity GO:0004716: receptor signaling protein tyrosine kinase activity GO:0034436: glycoprotein transport GO:0002042: cell migration involved in sprouting angiogenesis GO:0051414: response to cortisol stimulus GO:0045569: TRAIL binding GO:0042577: lipid phosphatase activity GO:0007519: skeletal muscle tissue development GO:0002903: negative regulation of B cell apoptosis GO:0043088: regulation of Cdc42 GTPase activity GO:0033484: nitric oxide homeostasis GO:0021860: pyramidal neuron development GO:0021549: cerebellum development GO:0044330: canonical Wnt receptor signaling pathway involved in positive regulation of wound healing GO:0030510: regulation of BMP signaling pathway GO:0031116: positive regulation of microtubule polymerization GO:0060349: bone morphogenesis GO:0048593: camera-type eye morphogenesis GO:0070301: cellular response to hydrogen peroxide GO:0045749: negative regulation of S phase of mitotic cell cycle GO:0090072: positive regulation of sodium ion transport via voltage-gated sodium channel activity GO:0003215: cardiac right ventricle morphogenesis GO:0015307: drug:hydrogen antiporter activity GO:0021631: optic nerve morphogenesis GO:0030849: autosome GO:0035255: ionotropic glutamate receptor binding GO:0009072: aromatic amino acid family metabolic process GO:0050966: detection of mechanical stimulus involved in sensory perception of pain GO:0051297: centrosome organization GO:0051984: positive regulation of chromosome segregation GO:0016167: glial cell line-derived neurotrophic factor receptor activity GO:0010827: regulation of glucose transport GO:0030828: positive regulation of cGMP biosynthetic process GO:0060442: branching involved in prostate gland morphogenesis GO:0030148: sphingolipid biosynthetic process GO:0032024: positive regulation of insulin secretion GO:0001960: negative regulation of cytokine-mediated signaling pathway GO:0043121: neurotrophin binding GO:0010593: negative regulation of lamellipodium assembly GO:0048730: epidermis morphogenesis GO:0060992: response to fungicide GO:0032956: regulation of actin cytoskeleton organization GO:0015227: acyl carnitine transporter activity GO:0071230: cellular response to amino acid stimulus GO:0060201: clathrin sculpted acetylcholine transport vesicle membrane GO:0045576: mast cell activation GO:0021575: hindbrain morphogenesis GO:0005681: spliceosomal complex GO:0032201: telomere maintenance via semi-conservative replication GO:0010468: regulation of gene expression GO:0008542: visual learning GO:0005369: taurine:sodium symporter activity GO:0005815: microtubule organizing center GO:0001975: response to amphetamine GO:0016290: palmitoyl-CoA hydrolase activity GO:0071445: cellular response to protein stimulus GO:0016444: somatic cell DNA recombination GO:0005477: pyruvate secondary active transmembrane transporter activity GO:0050062: long-chain-fatty-acyl-CoA reductase activity GO:0008188: neuropeptide receptor activity GO:0007589: body fluid secretion GO:0042627: chylomicron GO:0043006: activation of phospholipase A2 activity by calcium-mediated signaling GO:0048489: synaptic vesicle transport GO:0034380: high-density lipoprotein particle assembly GO:0051412: response to corticosterone stimulus GO:0042584: chromaffin granule membrane GO:0032367: intracellular cholesterol transport GO:2000096: positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway GO:0021836: chemorepulsion involved in postnatal olfactory bulb interneuron migration GO:0048169: regulation of long-term neuronal synaptic plasticity GO:0004713: protein tyrosine kinase activity GO:0070367: negative regulation of hepatocyte differentiation GO:0071363: cellular response to growth factor stimulus GO:0000979: RNA polymerase II core promoter sequence-specific DNA binding GO:0043433: negative regulation of transcription factor activity GO:0007346: regulation of mitotic cell cycle GO:0017134: fibroblast growth factor binding GO:0017156: calcium ion-dependent exocytosis GO:0050690: regulation of defense response to virus by virus GO:0004972: N-methyl-D-aspartate selective glutamate receptor activity GO:0050929: induction of negative chemotaxis GO:0016155: formyltetrahydrofolate dehydrogenase activity GO:0017129: triglyceride binding GO:0045861: negative regulation of proteolysis GO:0044328: canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration GO:0014063: negative regulation of serotonin secretion GO:0021972: corticospinal neuron axon guidance through spinal cord GO:0004502: kynurenine 3-monooxygenase activity GO:0030345: structural constituent of tooth enamel GO:0033993: response to lipid GO:0018272: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine GO:0015630: microtubule cytoskeleton GO:0046061: dATP catabolic process GO:0031146: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0071359: cellular response to dsRNA GO:0002158: osteoclast proliferation GO:0007189: activation of adenylate cyclase activity by G-protein signaling pathway GO:0048266: behavioral response to pain GO:0033700: phospholipid efflux GO:0019005: SCF ubiquitin ligase complex GO:0021891: olfactory bulb interneuron development GO:0008344: adult locomotory behavior GO:0010872: regulation of cholesterol esterification GO:0051480: cytosolic calcium ion homeostasis GO:0009720: detection of hormone stimulus GO:0040023: establishment of nucleus localization GO:0061003: positive regulation of dendritic spine morphogenesis GO:0046464: acylglycerol catabolic process GO:0005547: phosphatidylinositol-3,4,5-trisphosphate binding GO:0043186: P granule GO:0034041: sterol-transporting ATPase activity GO:0060056: mammary gland involution GO:0060915: mesenchymal cell differentiation involved in lung development GO:0005250: A-type (transient outward) potassium channel activity GO:0051668: localization within membrane GO:0048488: synaptic vesicle endocytosis GO:0042417: dopamine metabolic process GO:0060029: convergent extension involved in organogenesis GO:0042089: cytokine biosynthetic process GO:0016174: NAD(P)H oxidase activity GO:0060311: negative regulation of elastin catabolic process GO:0010332: response to gamma radiation GO:0042058: regulation of epidermal growth factor receptor signaling pathway GO:0042445: hormone metabolic process GO:0030235: nitric-oxide synthase regulator activity GO:0035555: initiation of Roundabout signal transduction GO:0019344: cysteine biosynthetic process GO:0090007: regulation of mitotic anaphase GO:0000096: sulfur amino acid metabolic process GO:0004121: cystathionine beta-lyase activity GO:0051150: regulation of smooth muscle cell differentiation GO:0010875: positive regulation of cholesterol efflux GO:0060045: positive regulation of cardiac muscle cell proliferation GO:0030595: leukocyte chemotaxis GO:0016331: morphogenesis of embryonic epithelium GO:0042059: negative regulation of epidermal growth factor receptor signaling pathway GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway GO:0000730: DNA recombinase assembly GO:0015355: secondary active monocarboxylate transmembrane transporter activity GO:0043274: phospholipase binding GO:0071805: potassium ion transmembrane transport GO:0017146: N-methyl-D-aspartate selective glutamate receptor complex GO:0051017: actin filament bundle assembly GO:0032410: negative regulation of transporter activity GO:0015068: glycine amidinotransferase activity GO:0071300: cellular response to retinoic acid GO:0005248: voltage-gated sodium channel activity GO:0008074: guanylate cyclase complex, soluble GO:0050928: negative regulation of positive chemotaxis GO:0015226: carnitine transporter activity GO:0014047: glutamate secretion GO:0006975: DNA damage induced protein phosphorylation GO:0043408: regulation of MAPKKK cascade GO:0070976: TIR domain binding GO:0046952: ketone body catabolic process GO:0032091: negative regulation of protein binding GO:0045920: negative regulation of exocytosis GO:0017127: cholesterol transporter activity GO:0008815: citrate (pro-3S)-lyase activity GO:0010952: positive regulation of peptidase activity GO:0007157: heterophilic cell-cell adhesion GO:0051605: protein maturation by peptide bond cleavage GO:0004677: DNA-dependent protein kinase activity GO:0042063: gliogenesis GO:0010044: response to aluminum ion GO:0071777: positive regulation of cell cycle cytokinesis GO:0014051: gamma-aminobutyric acid secretion GO:0035108: limb morphogenesis GO:0050544: arachidonic acid binding GO:0043113: receptor clustering GO:0030888: regulation of B cell proliferation GO:0090260: negative regulation of retinal ganglion cell axon guidance GO:0004016: adenylate cyclase activity GO:0047372: acylglycerol lipase activity GO:0031659: positive regulation of cyclin-dependent protein kinase activity involved in G1/S GO:0090288: negative regulation of cellular response to growth factor stimulus GO:0032497: detection of lipopolysaccharide GO:0030644: cellular chloride ion homeostasis GO:0050693: LBD domain binding GO:0031532: actin cytoskeleton reorganization GO:0032808: lacrimal gland development GO:0043981: histone H4-K5 acetylation GO:0033278: cell proliferation in midbrain GO:0051058: negative regulation of small GTPase mediated signal transduction GO:0017158: regulation of calcium ion-dependent exocytosis GO:0007431: salivary gland development GO:0048608: reproductive structure development GO:0046619: optic placode formation involved in camera-type eye formation GO:0010212: response to ionizing radiation GO:0051585: negative regulation of dopamine uptake GO:0008131: primary amine oxidase activity GO:0019363: pyridine nucleotide biosynthetic process GO:0007276: gamete generation GO:0051597: response to methylmercury GO:0005958: DNA-dependent protein kinase-DNA ligase 4 complex GO:0003329: pancreatic PP cell fate commitment GO:0010886: positive regulation of cholesterol storage GO:0060039: pericardium development GO:0055100: adiponectin binding GO:0016600: flotillin complex GO:0006907: pinocytosis GO:0071547: piP-body GO:0004710: MAP/ERK kinase kinase activity GO:0003956: NAD(P)+-protein-arginine ADP-ribosyltransferase activity GO:0042524: negative regulation of tyrosine phosphorylation of Stat5 protein GO:0033327: Leydig cell differentiation GO:0021754: facial nucleus development GO:0015057: thrombin receptor activity GO:0005121: Toll binding GO:0006465: signal peptide processing GO:0009651: response to salt stress GO:0047961: glycine N-acyltransferase activity GO:0015491: cation:cation antiporter activity GO:0060449: bud elongation involved in lung branching GO:0051622: negative regulation of norepinephrine uptake GO:0008406: gonad development GO:0060612: adipose tissue development GO:0001517: N-acetylglucosamine 6-O-sulfotransferase activity GO:0001561: fatty acid alpha-oxidation GO:2000016: negative regulation of determination of dorsal identity GO:0006904: vesicle docking involved in exocytosis GO:0030122: AP-2 adaptor complex GO:0016742: hydroxymethyl-, formyl- and related transferase activity GO:0050902: leukocyte adhesive activation GO:0031047: gene silencing by RNA GO:0006261: DNA-dependent DNA replication GO:0071456: cellular response to hypoxia GO:0050692: DBD domain binding GO:0070876: SOSS complex GO:0006584: catecholamine metabolic process GO:0001669: acrosomal vesicle GO:0021679: cerebellar molecular layer development GO:0032569: gene-specific transcription from RNA polymerase II promoter GO:0045773: positive regulation of axon extension GO:0010269: response to selenium ion GO:0010721: negative regulation of cell development GO:0006725: cellular aromatic compound metabolic process GO:0030273: melanin-concentrating hormone receptor activity GO:0070328: triglyceride homeostasis GO:0007387: anterior compartment pattern formation GO:0032314: regulation of Rac GTPase activity GO:0030349: syntaxin-13 binding GO:0010551: regulation of gene-specific transcription from RNA polymerase II promoter GO:0060205: cytoplasmic membrane-bounded vesicle lumen GO:0010887: negative regulation of cholesterol storage GO:0030117: membrane coat GO:0050671: positive regulation of lymphocyte proliferation GO:0048541: Peyer's patch development GO:0051612: negative regulation of serotonin uptake GO:0043069: negative regulation of programmed cell death GO:0030146: diuresis GO:0050927: positive regulation of positive chemotaxis GO:0034103: regulation of tissue remodeling GO:0050775: positive regulation of dendrite morphogenesis GO:0033563: dorsal/ventral axon guidance GO:0010890: positive regulation of sequestering of triglyceride GO:0080008: CUL4 RING ubiquitin ligase complex GO:0060313: negative regulation of blood vessel remodeling GO:0016830: carbon-carbon lyase activity GO:0045019: negative regulation of nitric oxide biosynthetic process GO:0043548: phosphatidylinositol 3-kinase binding GO:0021750: vestibular nucleus development GO:0007616: long-term memory GO:0060849: regulation of transcription involved in lymphatic endothelial cell fate commitment GO:0043206: fibril organization GO:0048846: axon extension involved in axon guidance GO:0015697: quaternary ammonium group transport GO:0018146: keratan sulfate biosynthetic process GO:0030193: regulation of blood coagulation GO:0051964: negative regulation of synaptogenesis GO:0006983: ER overload response GO:0006790: sulfur compound metabolic process GO:0006283: transcription-coupled nucleotide-excision repair GO:0060615: mammary gland bud formation GO:0003322: pancreatic A cell development GO:0061037: negative regulation of cartilage development GO:0032747: positive regulation of interleukin-23 production GO:0009346: citrate lyase complex GO:0015347: sodium-independent organic anion transmembrane transporter activity GO:0015375: glycine:sodium symporter activity GO:0034437: glycoprotein transporter activity GO:0045080: positive regulation of chemokine biosynthetic process GO:0071902: positive regulation of protein serine/threonine kinase activity GO:0031694: alpha-2A adrenergic receptor binding GO:0016486: peptide hormone processing GO:0042327: positive regulation of phosphorylation GO:0042997: negative regulation of Golgi to plasma membrane protein transport GO:0043983: histone H4-K12 acetylation GO:0035603: fibroblast growth factor receptor signaling pathway involved in hemopoiesis GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0008610: lipid biosynthetic process GO:0008266: poly(U) RNA binding GO:0005123: death receptor binding GO:0033344: cholesterol efflux GO:0045717: negative regulation of fatty acid biosynthetic process GO:0070652: HAUS complex GO:0035607: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0070100: negative regulation of chemokine-mediated signaling pathway GO:0006844: acyl carnitine transport GO:0070858: negative regulation of bile acid biosynthetic process GO:0043114: regulation of vascular permeability GO:0048495: Roundabout binding GO:0043982: histone H4-K8 acetylation GO:0030215: semaphorin receptor binding GO:0005030: neurotrophin receptor activity GO:0006271: DNA strand elongation involved in DNA replication GO:0008306: associative learning GO:0010350: cellular response to magnesium starvation GO:0030288: outer membrane-bounded periplasmic space GO:0045600: positive regulation of fat cell differentiation GO:0090136: epithelial cell-cell adhesion GO:0007256: activation of JNKK activity GO:0021590: cerebellum maturation GO:0090083: regulation of inclusion body assembly GO:0005326: neurotransmitter transporter activity GO:0001101: response to acid GO:0032914: positive regulation of transforming growth factor-beta1 production GO:0004758: serine C-palmitoyltransferase activity GO:0001950: plasma membrane enriched fraction GO:0000790: nuclear chromatin GO:0008184: glycogen phosphorylase activity GO:0071425: hemopoietic stem cell proliferation GO:0046618: drug export GO:0030032: lamellipodium assembly GO:0048066: developmental pigmentation GO:0042640: anagen GO:0044329: canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion GO:0003148: outflow tract septum morphogenesis GO:0032261: purine nucleotide salvage GO:0014823: response to activity GO:0002238: response to molecule of fungal origin GO:0007158: neuron cell-cell adhesion GO:0010040: response to iron(II) ion GO:0060407: negative regulation of penile erection GO:0010642: negative regulation of platelet-derived growth factor receptor signaling pathway GO:0051902: negative regulation of mitochondrial depolarization GO:0044424: intracellular part GO:0031177: phosphopantetheine binding GO:0042582: azurophil granule GO:0016291: acyl-CoA thioesterase activity GO:0004708: MAP kinase kinase activity GO:0006601: creatine biosynthetic process GO:0060670: branching involved in embryonic placenta morphogenesis GO:0007159: leukocyte cell-cell adhesion GO:0010711: negative regulation of collagen catabolic process GO:0003151: outflow tract morphogenesis GO:0042312: regulation of vasodilation GO:0045197: establishment or maintenance of epithelial cell apical/basal polarity GO:0000060: protein import into nucleus, translocation GO:0003851: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity GO:0070435: Shc-EGFR complex GO:0031576: G2/M transition checkpoint GO:0001836: release of cytochrome c from mitochondria GO:0030977: taurine binding GO:0071813: lipoprotein particle binding GO:0031394: positive regulation of prostaglandin biosynthetic process GO:0043405: regulation of MAP kinase activity GO:0030119: AP-type membrane coat adaptor complex GO:0043208: glycosphingolipid binding GO:0071407: cellular response to organic cyclic compound GO:0030916: otic vesicle formation GO:0008294: calcium- and calmodulin-responsive adenylate cyclase activity GO:0061202: clathrin sculpted gamma-aminobutyric acid transport vesicle membrane GO:0034765: regulation of ion transmembrane transport GO:0070372: regulation of ERK1 and ERK2 cascade GO:0032792: negative regulation of CREB transcription factor activity GO:0001967: suckling behavior GO:0008513: secondary active organic cation transmembrane transporter activity GO:0032926: negative regulation of activin receptor signaling pathway GO:0060529: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:0032353: negative regulation of hormone biosynthetic process GO:0007199: G-protein signaling, coupled to cGMP nucleotide second messenger GO:0002906: negative regulation of mature B cell apoptosis GO:0048015: phosphatidylinositol-mediated signaling GO:0060429: epithelium development GO:0042747: circadian sleep/wake cycle, REM sleep GO:0050702: interleukin-1 beta secretion GO:0015949: nucleobase, nucleoside and nucleotide interconversion GO:0071679: commissural neuron axon guidance GO:0055009: atrial cardiac muscle tissue morphogenesis GO:0055096: low-density lipoprotein particle mediated signaling GO:0002689: negative regulation of leukocyte chemotaxis GO:0010703: negative regulation of histolysis GO:0006944: cellular membrane fusion GO:0043620: regulation of transcription in response to stress GO:0071676: negative regulation of mononuclear cell migration GO:0046882: negative regulation of follicle-stimulating hormone secretion GO:0016576: histone dephosphorylation GO:0005152: interleukin-1 receptor antagonist activity GO:0008260: 3-oxoacid CoA-transferase activity GO:0048762: mesenchymal cell differentiation GO:0048841: regulation of axon extension involved in axon guidance GO:0010517: regulation of phospholipase activity GO:0055106: ubiquitin-protein ligase regulator activity GO:0009967: positive regulation of signal transduction GO:0005251: delayed rectifier potassium channel activity GO:0070830: tight junction assembly GO:0005109: frizzled binding GO:0070495: negative regulation of thrombin receptor signaling pathway GO:0032740: positive regulation of interleukin-17 production GO:0005522: profilin binding GO:0045964: positive regulation of dopamine metabolic process GO:0042805: actinin binding GO:0042987: amyloid precursor protein catabolic process GO:0050883: musculoskeletal movement, spinal reflex action GO:0004334: fumarylacetoacetase activity GO:0005007: fibroblast growth factor receptor activity GO:0007243: intracellular protein kinase cascade GO:0030282: bone mineralization GO:0050432: catecholamine secretion GO:0035067: negative regulation of histone acetylation GO:0071287: cellular response to manganese ion GO:0005657: replication fork GO:0001554: luteolysis GO:0030118: clathrin coat GO:0031045: dense core granule GO:0035413: positive regulation of catenin import into nucleus GO:0006157: deoxyadenosine catabolic process GO:0071396: cellular response to lipid GO:0032584: growth cone membrane GO:0050850: positive regulation of calcium-mediated signaling GO:0010460: positive regulation of heart rate GO:0043199: sulfate binding GO:0010453: regulation of cell fate commitment GO:0031267: small GTPase binding GO:0007388: posterior compartment specification GO:0006303: double-strand break repair via nonhomologous end joining GO:0022612: gland morphogenesis GO:0051798: positive regulation of hair follicle development GO:0043537: negative regulation of blood vessel endothelial cell migration GO:0001829: trophectodermal cell differentiation GO:0032277: negative regulation of gonadotropin secretion GO:0015651: quaternary ammonium group transmembrane transporter activity GO:0005068: transmembrane receptor protein tyrosine kinase adaptor activity GO:0015012: heparan sulfate proteoglycan biosynthetic process GO:0051443: positive regulation of ubiquitin-protein ligase activity GO:0042272: nuclear RNA export factor complex GO:0048286: lung alveolus development GO:0010633: negative regulation of epithelial cell migration GO:0060601: lateral sprouting from an epithelium GO:0002244: hemopoietic progenitor cell differentiation GO:0060155: platelet dense granule organization GO:0006171: cAMP biosynthetic process GO:0015802: basic amino acid transport GO:0019907: cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0048041: focal adhesion assembly GO:0002088: lens development in camera-type eye GO:0005662: DNA replication factor A complex GO:0001780: neutrophil homeostasis GO:0008045: motor axon guidance GO:0050862: positive regulation of T cell receptor signaling pathway Names total elements #1043IR #1051IR #1063IR #1095IR #10IR 70 GO:0006810: transport GO:0005515: protein binding GO:0005789: endoplasmic reticulum membrane GO:0007264: small GTPase mediated signal transduction GO:0045202: synapse GO:0005730: nucleolus GO:0006813: potassium ion transport GO:0007420: brain development GO:0042803: protein homodimerization activity GO:0016787: hydrolase activity GO:0007584: response to nutrient GO:0008233: peptidase activity GO:0001503: ossification GO:0004872: receptor activity GO:0005216: ion channel activity GO:0006979: response to oxidative stress GO:0006897: endocytosis GO:0007268: synaptic transmission GO:0005622: intracellular GO:0016021: integral to membrane GO:0004252: serine-type endopeptidase activity GO:0008270: zinc ion binding GO:0017124: SH3 domain binding GO:0005525: GTP binding GO:0008239: dipeptidyl-peptidase activity GO:0008083: growth factor activity GO:0046872: metal ion binding GO:0005516: calmodulin binding GO:0005509: calcium ion binding GO:0019901: protein kinase binding GO:0006508: proteolysis GO:0007186: G-protein coupled receptor protein signaling pathway GO:0030054: cell junction GO:0006811: ion transport GO:0005215: transporter activity GO:0000287: magnesium ion binding GO:0045211: postsynaptic membrane GO:0007259: JAK-STAT cascade GO:0016740: transferase activity GO:0005576: extracellular region GO:0008150: biological_process GO:0004930: G-protein coupled receptor activity GO:0005886: plasma membrane GO:0003674: molecular_function GO:0030154: cell differentiation GO:0007267: cell-cell signaling GO:0008289: lipid binding GO:0005783: endoplasmic reticulum GO:0003924: GTPase activity GO:0009986: cell surface GO:0008152: metabolic process GO:0016020: membrane GO:0005615: extracellular space GO:0006814: sodium ion transport GO:0005624: membrane fraction GO:0007156: homophilic cell adhesion GO:0005524: ATP binding GO:0005737: cytoplasm GO:0000166: nucleotide binding GO:0007399: nervous system development GO:0006874: cellular calcium ion homeostasis GO:0005125: cytokine activity GO:0007165: signal transduction GO:0005634: nucleus GO:0007155: cell adhesion GO:0005739: mitochondrion GO:0005887: integral to plasma membrane GO:0005254: chloride channel activity GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0005794: Golgi apparatus #1043IR #1051IR #1095IR #10IR 3 GO:0016820: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0045786: negative regulation of cell cycle GO:0006754: ATP biosynthetic process #1043IR #1063IR #1095IR #10IR 22 GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein GO:0001837: epithelial to mesenchymal transition GO:0007204: elevation of cytosolic calcium ion concentration GO:0016042: lipid catabolic process GO:0017046: peptide hormone binding GO:0042110: T cell activation GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation GO:0005234: extracellular-glutamate-gated ion channel activity GO:0015277: kainate selective glutamate receptor activity GO:0008430: selenium binding GO:0006107: oxaloacetate metabolic process GO:0042802: identical protein binding GO:0000187: activation of MAPK activity GO:0019953: sexual reproduction GO:0008076: voltage-gated potassium channel complex GO:0001666: response to hypoxia GO:0070064: proline-rich region binding GO:0004177: aminopeptidase activity GO:0007588: excretion GO:0006631: fatty acid metabolic process GO:0005625: soluble fraction GO:0007389: pattern specification process #1051IR #1063IR #1095IR #10IR 172 GO:0030674: protein binding, bridging GO:0006915: apoptosis GO:0007409: axonogenesis GO:0016481: negative regulation of transcription GO:0042310: vasoconstriction GO:0048246: macrophage chemotaxis GO:0050896: response to stimulus GO:0006355: regulation of transcription, DNA-dependent GO:0007601: visual perception GO:0031225: anchored to membrane GO:0006641: triglyceride metabolic process GO:0043565: sequence-specific DNA binding GO:0042632: cholesterol homeostasis GO:0003676: nucleic acid binding GO:0006461: protein complex assembly GO:0030539: male genitalia development GO:0007605: sensory perception of sound GO:0016323: basolateral plasma membrane GO:0042475: odontogenesis of dentine-containing tooth GO:0043234: protein complex GO:0008284: positive regulation of cell proliferation GO:0042734: presynaptic membrane GO:0006958: complement activation, classical pathway GO:0005200: structural constituent of cytoskeleton GO:0005161: platelet-derived growth factor receptor binding GO:0030173: integral to Golgi membrane GO:0042127: regulation of cell proliferation GO:0004528: phosphodiesterase I activity GO:0030659: cytoplasmic vesicle membrane GO:0016757: transferase activity, transferring glycosyl groups GO:0050839: cell adhesion molecule binding GO:0005518: collagen binding GO:0006812: cation transport GO:0040008: regulation of growth GO:0006869: lipid transport GO:0004867: serine-type endopeptidase inhibitor activity GO:0008134: transcription factor binding GO:0009611: response to wounding GO:0015293: symporter activity GO:0050656: 3'-phosphoadenosine 5'-phosphosulfate binding GO:0008380: RNA splicing GO:0016477: cell migration GO:0006836: neurotransmitter transport GO:0030346: protein phosphatase 2B binding GO:0048306: calcium-dependent protein binding GO:0008201: heparin binding GO:0030324: lung development GO:0005923: tight junction GO:0005575: cellular_component GO:0005813: centrosome GO:0019838: growth factor binding GO:0005085: guanyl-nucleotide exchange factor activity GO:0016023: cytoplasmic membrane-bounded vesicle GO:0016491: oxidoreductase activity GO:0043193: positive regulation of gene-specific transcription GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0009055: electron carrier activity GO:0005021: vascular endothelial growth factor receptor activity GO:0004176: ATP-dependent peptidase activity GO:0030505: inorganic diphosphate transport GO:0048008: platelet-derived growth factor receptor signaling pathway GO:0003779: actin binding GO:0030027: lamellipodium GO:0016324: apical plasma membrane GO:0009653: anatomical structure morphogenesis GO:0006816: calcium ion transport GO:0007586: digestion GO:0016942: insulin-like growth factor binding protein complex GO:0045087: innate immune response GO:0009968: negative regulation of signal transduction GO:0008283: cell proliferation GO:0006952: defense response GO:0005604: basement membrane GO:0016192: vesicle-mediated transport GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway GO:0016887: ATPase activity GO:0000278: mitotic cell cycle GO:0032869: cellular response to insulin stimulus GO:0008015: blood circulation GO:0045121: membrane raft GO:0003677: DNA binding GO:0007275: multicellular organismal development GO:0005578: proteinaceous extracellular matrix GO:0006886: intracellular protein transport GO:0005829: cytosol GO:0042594: response to starvation GO:0030334: regulation of cell migration GO:0009725: response to hormone stimulus GO:0022900: electron transport chain GO:0001570: vasculogenesis GO:0016563: transcription activator activity GO:0006334: nucleosome assembly GO:0006357: regulation of transcription from RNA polymerase II promoter GO:0031994: insulin-like growth factor I binding GO:0005488: binding GO:0031410: cytoplasmic vesicle GO:0005230: extracellular ligand-gated ion channel activity GO:0001558: regulation of cell growth GO:0007194: negative regulation of adenylate cyclase activity GO:0005769: early endosome GO:0001755: neural crest cell migration GO:0048662: negative regulation of smooth muscle cell proliferation GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0050501: hyaluronan synthase activity GO:0007179: transforming growth factor beta receptor signaling pathway GO:0019717: synaptosome GO:0008285: negative regulation of cell proliferation GO:0012505: endomembrane system GO:0045449: regulation of transcription GO:0051020: GTPase binding GO:0008219: cell death GO:0000139: Golgi membrane GO:0030521: androgen receptor signaling pathway GO:0006629: lipid metabolic process GO:0007417: central nervous system development GO:0042981: regulation of apoptosis GO:0004674: protein serine/threonine kinase activity GO:0014912: negative regulation of smooth muscle cell migration GO:0030198: extracellular matrix organization GO:0031093: platelet alpha granule lumen GO:0006916: anti-apoptosis GO:0016337: cell-cell adhesion GO:0006457: protein folding GO:0005506: iron ion binding GO:0030500: regulation of bone mineralization GO:0030162: regulation of proteolysis GO:0007229: integrin-mediated signaling pathway GO:0005057: receptor signaling protein activity GO:0005856: cytoskeleton GO:0030335: positive regulation of cell migration GO:0007528: neuromuscular junction development GO:0030199: collagen fibril organization GO:0003774: motor activity GO:0003824: catalytic activity GO:0004222: metalloendopeptidase activity GO:0007200: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0005540: hyaluronic acid binding GO:0006796: phosphate metabolic process GO:0008168: methyltransferase activity GO:0006826: iron ion transport GO:0019722: calcium-mediated signaling GO:0001726: ruffle GO:0004871: signal transducer activity GO:0005882: intermediate filament GO:0030426: growth cone GO:0042391: regulation of membrane potential GO:0005529: sugar binding GO:0015031: protein transport GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0007507: heart development GO:0005244: voltage-gated ion channel activity GO:0003723: RNA binding GO:0006955: immune response GO:0004551: nucleotide diphosphatase activity GO:0008217: regulation of blood pressure GO:0030528: transcription regulator activity GO:0005096: GTPase activator activity GO:0005158: insulin receptor binding GO:0006954: inflammatory response GO:0009887: organ morphogenesis GO:0008378: galactosyltransferase activity GO:0030308: negative regulation of cell growth GO:0005201: extracellular matrix structural constituent GO:0007171: activation of transmembrane receptor protein tyrosine kinase activity GO:0005911: cell-cell junction GO:0010008: endosome membrane GO:0048471: perinuclear region of cytoplasm GO:0046982: protein heterodimerization activity GO:0005874: microtubule GO:0005507: copper ion binding GO:0045599: negative regulation of fat cell differentiation GO:0006091: generation of precursor metabolites and energy #1043IR #1051IR #1063IR #10IR 1 GO:0030165: PDZ domain binding #1043IR #1051IR #1063IR #1095IR 4 GO:0007626: locomotory behavior GO:0005249: voltage-gated potassium channel activity GO:0004896: cytokine receptor activity GO:0005179: hormone activity #1043IR #1095IR #10IR 6 GO:0005391: sodium:potassium-exchanging ATPase activity GO:0019861: flagellum GO:0051216: cartilage development GO:0005929: cilium GO:0019695: choline metabolic process GO:0040007: growth #1051IR #1095IR #10IR 27 GO:0046627: negative regulation of insulin receptor signaling pathway GO:0014826: vein smooth muscle contraction GO:0003707: steroid hormone receptor activity GO:0045719: negative regulation of glycogen biosynthetic process GO:0047429: nucleoside-triphosphate diphosphatase activity GO:0043034: costamere GO:0045722: positive regulation of gluconeogenesis GO:0050427: 3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0008307: structural constituent of muscle GO:0009143: nucleoside triphosphate catabolic process GO:0050909: sensory perception of taste GO:0051082: unfolded protein binding GO:0030730: sequestering of triglyceride GO:0001600: endothelin-B receptor activity GO:0009187: cyclic nucleotide metabolic process GO:0006885: regulation of pH GO:0006397: mRNA processing GO:0006367: transcription initiation from RNA polymerase II promoter GO:0030643: cellular phosphate ion homeostasis GO:0050681: androgen receptor binding GO:0030374: ligand-dependent nuclear receptor transcription coactivator activity GO:0007187: G-protein signaling, coupled to cyclic nucleotide second messenger GO:0000086: G2/M transition of mitotic cell cycle GO:0007368: determination of left/right symmetry GO:0030145: manganese ion binding GO:0016455: RNA polymerase II transcription mediator activity GO:0046325: negative regulation of glucose import #1063IR #1095IR #10IR 369 GO:0048705: skeletal system morphogenesis GO:0043184: vascular endothelial growth factor receptor 2 binding GO:0045787: positive regulation of cell cycle GO:0032587: ruffle membrane GO:0001942: hair follicle development GO:0001540: beta-amyloid binding GO:0005770: late endosome GO:0043536: positive regulation of blood vessel endothelial cell migration GO:0006950: response to stress GO:0043204: perikaryon GO:0044419: interspecies interaction between organisms GO:0004888: transmembrane receptor activity GO:0019221: cytokine-mediated signaling pathway GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0032355: response to estradiol stimulus GO:0001764: neuron migration GO:0005159: insulin-like growth factor receptor binding GO:0051291: protein heterooligomerization GO:0043627: response to estrogen stimulus GO:0042626: ATPase activity, coupled to transmembrane movement of substances GO:0042169: SH2 domain binding GO:0032874: positive regulation of stress-activated MAPK cascade GO:0016032: viral reproduction GO:0000902: cell morphogenesis GO:0046983: protein dimerization activity GO:0008624: induction of apoptosis by extracellular signals GO:0005922: connexon complex GO:0006688: glycosphingolipid biosynthetic process GO:0031902: late endosome membrane GO:0005759: mitochondrial matrix GO:0008236: serine-type peptidase activity GO:0004197: cysteine-type endopeptidase activity GO:0043231: intracellular membrane-bounded organelle GO:0006911: phagocytosis, engulfment GO:0008009: chemokine activity GO:0008415: acyltransferase activity GO:0005778: peroxisomal membrane GO:0006805: xenobiotic metabolic process GO:0030879: mammary gland development GO:0005952: cAMP-dependent protein kinase complex GO:0030425: dendrite GO:0043120: tumor necrosis factor binding GO:0006695: cholesterol biosynthetic process GO:0042995: cell projection GO:0008603: cAMP-dependent protein kinase regulator activity GO:0016607: nuclear speck GO:0008147: structural constituent of bone GO:0048741: skeletal muscle fiber development GO:0001937: negative regulation of endothelial cell proliferation GO:0016702: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0007411: axon guidance GO:0005543: phospholipid binding GO:0007173: epidermal growth factor receptor signaling pathway GO:0015333: peptide:hydrogen symporter activity GO:0043434: response to peptide hormone stimulus GO:0006112: energy reserve metabolic process GO:0050905: neuromuscular process GO:0000776: kinetochore GO:0003009: skeletal muscle contraction GO:0042476: odontogenesis GO:0008277: regulation of G-protein coupled receptor protein signaling pathway GO:0031557: induction of programmed cell death in response to chemical stimulus GO:0043197: dendritic spine GO:0043542: endothelial cell migration GO:0044262: cellular carbohydrate metabolic process GO:0042755: eating behavior GO:0009617: response to bacterium GO:0004842: ubiquitin-protein ligase activity GO:0046330: positive regulation of JNK cascade GO:0007435: salivary gland morphogenesis GO:0030307: positive regulation of cell growth GO:0048011: nerve growth factor receptor signaling pathway GO:0006919: activation of caspase activity GO:0001889: liver development GO:0031290: retinal ganglion cell axon guidance GO:0050900: leukocyte migration GO:0004623: phospholipase A2 activity GO:0008017: microtubule binding GO:0006511: ubiquitin-dependent protein catabolic process GO:0042493: response to drug GO:0007413: axonal fasciculation GO:0001541: ovarian follicle development GO:0006605: protein targeting GO:0001654: eye development GO:0019903: protein phosphatase binding GO:0005768: endosome GO:0043524: negative regulation of neuron apoptosis GO:0050806: positive regulation of synaptic transmission GO:0004568: chitinase activity GO:0031069: hair follicle morphogenesis GO:0019228: regulation of action potential in neuron GO:0008305: integrin complex GO:0004672: protein kinase activity GO:0004725: protein tyrosine phosphatase activity GO:0030036: actin cytoskeleton organization GO:0008286: insulin receptor signaling pathway GO:0007190: activation of adenylate cyclase activity GO:0031623: receptor internalization GO:0005771: multivesicular body GO:0005160: transforming growth factor beta receptor binding GO:0016050: vesicle organization GO:0001968: fibronectin binding GO:0051726: regulation of cell cycle GO:0048168: regulation of neuronal synaptic plasticity GO:0042325: regulation of phosphorylation GO:0015175: neutral amino acid transmembrane transporter activity GO:0005089: Rho guanyl-nucleotide exchange factor activity GO:0005758: mitochondrial intermembrane space GO:0015297: antiporter activity GO:0030900: forebrain development GO:0045892: negative regulation of transcription, DNA-dependent GO:0051966: regulation of synaptic transmission, glutamatergic GO:0016504: peptidase activator activity GO:0035094: response to nicotine GO:0016264: gap junction assembly GO:0016500: protein-hormone receptor activity GO:0006935: chemotaxis GO:0043525: positive regulation of neuron apoptosis GO:0006633: fatty acid biosynthetic process GO:0051384: response to glucocorticoid stimulus GO:0007218: neuropeptide signaling pathway GO:0006643: membrane lipid metabolic process GO:0003702: RNA polymerase II transcription factor activity GO:0006663: platelet activating factor biosynthetic process GO:0042605: peptide antigen binding GO:0006887: exocytosis GO:0010718: positive regulation of epithelial to mesenchymal transition GO:0004497: monooxygenase activity GO:0015629: actin cytoskeleton GO:0045726: positive regulation of integrin biosynthetic process GO:0006220: pyrimidine nucleotide metabolic process GO:0030326: embryonic limb morphogenesis GO:0047555: 3',5'-cyclic-GMP phosphodiesterase activity GO:0030170: pyridoxal phosphate binding GO:0031418: L-ascorbic acid binding GO:0006809: nitric oxide biosynthetic process GO:0001502: cartilage condensation GO:0008092: cytoskeletal protein binding GO:0006974: response to DNA damage stimulus GO:0060271: cilium morphogenesis GO:0050778: positive regulation of immune response GO:0019959: interleukin-8 binding GO:0042472: inner ear morphogenesis GO:0006892: post-Golgi vesicle-mediated transport GO:0007596: blood coagulation GO:0031295: T cell costimulation GO:0031966: mitochondrial membrane GO:0010693: negative regulation of alkaline phosphatase activity GO:0019966: interleukin-1 binding GO:0009409: response to cold GO:0006260: DNA replication GO:0005102: receptor binding GO:0050777: negative regulation of immune response GO:0016209: antioxidant activity GO:0042542: response to hydrogen peroxide GO:0060389: pathway-restricted SMAD protein phosphorylation GO:0015334: high affinity oligopeptide transporter activity GO:0043065: positive regulation of apoptosis GO:0008022: protein C-terminus binding GO:0051091: positive regulation of transcription factor activity GO:0043169: cation binding GO:0005868: cytoplasmic dynein complex GO:0019216: regulation of lipid metabolic process GO:0007214: gamma-aminobutyric acid signaling pathway GO:0030315: T-tubule GO:0007215: glutamate signaling pathway GO:0030182: neuron differentiation GO:0051891: positive regulation of cardioblast differentiation GO:0000075: cell cycle checkpoint GO:0007283: spermatogenesis GO:0005802: trans-Golgi network GO:0004089: carbonate dehydratase activity GO:0005792: microsome GO:0045941: positive regulation of transcription GO:0022601: menstrual cycle phase GO:0051018: protein kinase A binding GO:0016829: lyase activity GO:0007018: microtubule-based movement GO:0045177: apical part of cell GO:0005654: nucleoplasm GO:0043531: ADP binding GO:0001938: positive regulation of endothelial cell proliferation GO:0019430: removal of superoxide radicals GO:0048678: response to axon injury GO:0005520: insulin-like growth factor binding GO:0010575: positive regulation vascular endothelial growth factor production GO:0048663: neuron fate commitment GO:0019233: sensory perception of pain GO:0043066: negative regulation of apoptosis GO:0009615: response to virus GO:0005916: fascia adherens GO:0004437: inositol or phosphatidylinositol phosphatase activity GO:0051258: protein polymerization GO:0006879: cellular iron ion homeostasis GO:0005003: ephrin receptor activity GO:0001501: skeletal system development GO:0016798: hydrolase activity, acting on glycosyl bonds GO:0048103: somatic stem cell division GO:0043499: eukaryotic cell surface binding GO:0008146: sulfotransferase activity GO:0007585: respiratory gaseous exchange GO:0016568: chromatin modification GO:0045296: cadherin binding GO:0006032: chitin catabolic process GO:0009636: response to toxin GO:0051402: neuron apoptosis GO:0007623: circadian rhythm GO:0015893: drug transport GO:0016788: hydrolase activity, acting on ester bonds GO:0005777: peroxisome GO:0009966: regulation of signal transduction GO:0008021: synaptic vesicle GO:0045669: positive regulation of osteoblast differentiation GO:0048172: regulation of short-term neuronal synaptic plasticity GO:0043195: terminal button GO:0016363: nuclear matrix GO:0030552: cAMP binding GO:0005925: focal adhesion GO:0006936: muscle contraction GO:0005938: cell cortex GO:0004965: GABA-B receptor activity GO:0043027: caspase inhibitor activity GO:0003713: transcription coactivator activity GO:0032570: response to progesterone stimulus GO:0031012: extracellular matrix GO:0051015: actin filament binding GO:0051260: protein homooligomerization GO:0048545: response to steroid hormone stimulus GO:0005743: mitochondrial inner membrane GO:0051084: 'de novo' posttranslational protein folding GO:0009116: nucleoside metabolic process GO:0003828: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0050729: positive regulation of inflammatory response GO:0043154: negative regulation of caspase activity GO:0005765: lysosomal membrane GO:0045893: positive regulation of transcription, DNA-dependent GO:0051592: response to calcium ion GO:0006006: glucose metabolic process GO:0030018: Z disc GO:0030971: receptor tyrosine kinase binding GO:0045732: positive regulation of protein catabolic process GO:0005381: iron ion transmembrane transporter activity GO:0003682: chromatin binding GO:0008104: protein localization GO:0007067: mitosis GO:0030097: hemopoiesis GO:0008144: drug binding GO:0005114: type II transforming growth factor beta receptor binding GO:0017111: nucleoside-triphosphatase activity GO:0033630: positive regulation of cell adhesion mediated by integrin GO:0004143: diacylglycerol kinase activity GO:0006464: protein modification process GO:0031965: nuclear membrane GO:0016922: ligand-dependent nuclear receptor binding GO:0004046: aminoacylase activity GO:0051056: regulation of small GTPase mediated signal transduction GO:0015467: G-protein activated inward rectifier potassium channel activity GO:0015075: ion transmembrane transporter activity GO:0006469: negative regulation of protein kinase activity GO:0016874: ligase activity GO:0001947: heart looping GO:0045454: cell redox homeostasis GO:0010634: positive regulation of epithelial cell migration GO:0005080: protein kinase C binding GO:0030111: regulation of Wnt receptor signaling pathway GO:0034097: response to cytokine stimulus GO:0007010: cytoskeleton organization GO:0000785: chromatin GO:0050680: negative regulation of epithelial cell proliferation GO:0001525: angiogenesis GO:0007265: Ras protein signal transduction GO:0043005: neuron projection GO:0009395: phospholipid catabolic process GO:0042416: dopamine biosynthetic process GO:0005905: coated pit GO:0030424: axon GO:0009749: response to glucose stimulus GO:0003714: transcription corepressor activity GO:0006396: RNA processing GO:0006749: glutathione metabolic process GO:0060317: cardiac epithelial to mesenchymal transition GO:0042470: melanosome GO:0008028: monocarboxylic acid transmembrane transporter activity GO:0045778: positive regulation of ossification GO:0006096: glycolysis GO:0048666: neuron development GO:0004702: receptor signaling protein serine/threonine kinase activity GO:0043687: post-translational protein modification GO:0007160: cell-matrix adhesion GO:0008237: metallopeptidase activity GO:0031016: pancreas development GO:0060038: cardiac muscle cell proliferation GO:0048754: branching morphogenesis of a tube GO:0000165: MAPKKK cascade GO:0010038: response to metal ion GO:0050796: regulation of insulin secretion GO:0005667: transcription factor complex GO:0040014: regulation of multicellular organism growth GO:0030593: neutrophil chemotaxis GO:0048813: dendrite morphogenesis GO:0005198: structural molecule activity GO:0030496: midbody GO:0043043: peptide biosynthetic process GO:0020037: heme binding GO:0007049: cell cycle GO:0005694: chromosome GO:0000079: regulation of cyclin-dependent protein kinase activity GO:0005544: calcium-dependent phospholipid binding GO:0008016: regulation of heart contraction GO:0005635: nuclear envelope GO:0032909: regulation of transforming growth factor-beta2 production GO:0006281: DNA repair GO:0060021: palate development GO:0035023: regulation of Rho protein signal transduction GO:0019899: enzyme binding GO:0032147: activation of protein kinase activity GO:0015804: neutral amino acid transport GO:0000084: S phase of mitotic cell cycle GO:0042060: wound healing GO:0007154: cell communication GO:0004859: phospholipase inhibitor activity GO:0019904: protein domain specific binding GO:0009897: external side of plasma membrane GO:0006909: phagocytosis GO:0030139: endocytic vesicle GO:0051301: cell division GO:0007050: cell cycle arrest GO:0005741: mitochondrial outer membrane GO:0051219: phosphoprotein binding GO:0005764: lysosome GO:0031901: early endosome membrane GO:0043200: response to amino acid stimulus GO:0050770: regulation of axonogenesis GO:0046320: regulation of fatty acid oxidation GO:0016567: protein ubiquitination GO:0045766: positive regulation of angiogenesis GO:0006366: transcription from RNA polymerase II promoter GO:0048469: cell maturation GO:0008373: sialyltransferase activity GO:0022857: transmembrane transporter activity GO:0008203: cholesterol metabolic process GO:0008509: anion transmembrane transporter activity GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030168: platelet activation GO:0008656: caspase activator activity GO:0044267: cellular protein metabolic process GO:0045471: response to ethanol GO:0009612: response to mechanical stimulus GO:0009408: response to heat GO:0030100: regulation of endocytosis GO:0016564: transcription repressor activity GO:0045823: positive regulation of heart contraction GO:0007040: lysosome organization GO:0006139: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process GO:0030890: positive regulation of B cell proliferation GO:0030660: Golgi-associated vesicle membrane GO:0016459: myosin complex GO:0005975: carbohydrate metabolic process GO:0016055: Wnt receptor signaling pathway GO:0008347: glial cell migration GO:0019825: oxygen binding GO:0000777: condensed chromosome kinetochore GO:0004857: enzyme inhibitor activity GO:0048699: generation of neurons GO:0051795: positive regulation of catagen GO:0042593: glucose homeostasis GO:0000082: G1/S transition of mitotic cell cycle GO:0007205: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0051899: membrane depolarization #1043IR #1063IR #10IR 21 GO:0070195: growth hormone receptor complex GO:0046449: creatinine metabolic process GO:0046581: intercellular canaliculus GO:0044236: multicellular organismal metabolic process GO:0006105: succinate metabolic process GO:0032870: cellular response to hormone stimulus GO:0006101: citrate metabolic process GO:0006103: 2-oxoglutarate metabolic process GO:0006573: valine metabolic process GO:0060396: growth hormone receptor signaling pathway GO:0045184: establishment of protein localization GO:0006600: creatine metabolic process GO:0000255: allantoin metabolic process GO:0042977: activation of JAK2 kinase activity GO:0019530: taurine metabolic process GO:0033632: regulation of cell-cell adhesion mediated by integrin GO:0006549: isoleucine metabolic process GO:0007202: activation of phospholipase C activity GO:0040018: positive regulation of multicellular organism growth GO:0048009: insulin-like growth factor receptor signaling pathway GO:0042523: positive regulation of tyrosine phosphorylation of Stat5 protein #1051IR #1063IR #10IR 26 GO:0005319: lipid transporter activity GO:0004889: nicotinic acetylcholine-activated cation-selective channel activity GO:0050821: protein stabilization GO:0008013: beta-catenin binding GO:0006940: regulation of smooth muscle contraction GO:0005892: nicotinic acetylcholine-gated receptor-channel complex GO:0019898: extrinsic to membrane GO:0030178: negative regulation of Wnt receptor signaling pathway GO:0034394: protein localization at cell surface GO:0005178: integrin binding GO:0030863: cortical cytoskeleton GO:0015171: amino acid transmembrane transporter activity GO:0015464: acetylcholine receptor activity GO:0045597: positive regulation of cell differentiation GO:0005912: adherens junction GO:0006865: amino acid transport GO:0006953: acute-phase response GO:0003730: mRNA 3'-UTR binding GO:0030336: negative regulation of cell migration GO:0005581: collagen GO:0016339: calcium-dependent cell-cell adhesion GO:0060079: regulation of excitatory postsynaptic membrane potential GO:0007611: learning or memory GO:0007005: mitochondrion organization GO:0009312: oligosaccharide biosynthetic process GO:0042157: lipoprotein metabolic process #1043IR #1051IR #1095IR 5 GO:0031402: sodium ion binding GO:0007242: intracellular signaling cascade GO:0030955: potassium ion binding GO:0031404: chloride ion binding GO:0007166: cell surface receptor linked signal transduction #1043IR #1063IR #1095IR 3 GO:0043130: ubiquitin binding GO:0008195: phosphatidate phosphatase activity GO:0009791: post-embryonic development #1051IR #1063IR #1095IR 31 GO:0007219: Notch signaling pathway GO:0006917: induction of apoptosis GO:0001775: cell activation GO:0016310: phosphorylation GO:0043569: negative regulation of insulin-like growth factor receptor signaling pathway GO:0018108: peptidyl-tyrosine phosphorylation GO:0008499: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity GO:0017166: vinculin binding GO:0006559: L-phenylalanine catabolic process GO:0045028: purinergic nucleotide receptor activity, G-protein coupled GO:0045165: cell fate commitment GO:0007271: synaptic transmission, cholinergic GO:0005875: microtubule associated complex GO:0005793: ER-Golgi intermediate compartment GO:0048407: platelet-derived growth factor binding GO:0005891: voltage-gated calcium channel complex GO:0030318: melanocyte differentiation GO:0001542: ovulation from ovarian follicle GO:0007422: peripheral nervous system development GO:0000155: two-component sensor activity GO:0045740: positive regulation of DNA replication GO:0008360: regulation of cell shape GO:0016301: kinase activity GO:0005018: platelet-derived growth factor alpha-receptor activity GO:0017148: negative regulation of translation GO:0004890: GABA-A receptor activity GO:0048146: positive regulation of fibroblast proliferation GO:0005328: neurotransmitter:sodium symporter activity GO:0005245: voltage-gated calcium channel activity GO:0006572: tyrosine catabolic process GO:0015269: calcium-activated potassium channel activity #1095IR #10IR 145 GO:0031227: intrinsic to endoplasmic reticulum membrane GO:0006656: phosphatidylcholine biosynthetic process GO:0015078: hydrogen ion transmembrane transporter activity GO:0048538: thymus development GO:0045860: positive regulation of protein kinase activity GO:0003712: transcription cofactor activity GO:0006108: malate metabolic process GO:0030330: DNA damage response, signal transduction by p53 class mediator GO:0004540: ribonuclease activity GO:0006094: gluconeogenesis GO:0008301: DNA bending activity GO:0019001: guanyl nucleotide binding GO:0009650: UV protection GO:0005388: calcium-transporting ATPase activity GO:0007252: I-kappaB phosphorylation GO:0004004: ATP-dependent RNA helicase activity GO:0007188: G-protein signaling, coupled to cAMP nucleotide second messenger GO:0032963: collagen metabolic process GO:0004386: helicase activity GO:0030101: natural killer cell activation GO:0045859: regulation of protein kinase activity GO:0030176: integral to endoplasmic reticulum membrane GO:0004322: ferroxidase activity GO:0042612: MHC class I protein complex GO:0019439: aromatic compound catabolic process GO:0030553: cGMP binding GO:0007015: actin filament organization GO:0006222: UMP biosynthetic process GO:0004364: glutathione transferase activity GO:0017153: sodium:dicarboxylate symporter activity GO:0016070: RNA metabolic process GO:0002474: antigen processing and presentation of peptide antigen via MHC class I GO:0005834: heterotrimeric G-protein complex GO:0008544: epidermis development GO:0015992: proton transport GO:0008320: protein transmembrane transporter activity GO:0000186: activation of MAPKK activity GO:0006835: dicarboxylic acid transport GO:0005097: Rab GTPase activator activity GO:0042645: mitochondrial nucleoid GO:0032313: regulation of Rab GTPase activity GO:0016461: unconventional myosin complex GO:0030867: rough endoplasmic reticulum membrane GO:0005641: nuclear envelope lumen GO:0006164: purine nucleotide biosynthetic process GO:0048873: homeostasis of number of cells within a tissue GO:0001935: endothelial cell proliferation GO:0030216: keratinocyte differentiation GO:0045088: regulation of innate immune response GO:0000502: proteasome complex GO:0006509: membrane protein ectodomain proteolysis GO:0031941: filamentous actin GO:0000303: response to superoxide GO:0004104: cholinesterase activity GO:0043457: regulation of cellular respiration GO:0007565: female pregnancy GO:0016779: nucleotidyltransferase activity GO:0031424: keratinization GO:0060001: minus-end directed microfilament motor activity GO:0007405: neuroblast proliferation GO:0006210: thymine catabolic process GO:0015701: bicarbonate transport GO:0006212: uracil catabolic process GO:0006825: copper ion transport GO:0014850: response to muscle activity GO:0005070: SH3/SH2 adaptor activity GO:0015718: monocarboxylic acid transport GO:0004180: carboxypeptidase activity GO:0005452: inorganic anion exchanger activity GO:0048477: oogenesis GO:0014003: oligodendrocyte development GO:0043085: positive regulation of catalytic activity GO:0046920: alpha(1,3)-fucosyltransferase activity GO:0005247: voltage-gated chloride channel activity GO:0006986: response to unfolded protein GO:0019370: leukotriene biosynthetic process GO:0006214: thymidine catabolic process GO:0042254: ribosome biogenesis GO:0031638: zymogen activation GO:0045334: clathrin-coated endocytic vesicle GO:0003777: microtubule motor activity GO:0016881: acid-amino acid ligase activity GO:0006417: regulation of translation GO:0005788: endoplasmic reticulum lumen GO:0010181: FMN binding GO:0006821: chloride transport GO:0004385: guanylate kinase activity GO:0016747: transferase activity, transferring acyl groups other than amino-acyl groups GO:0046870: cadmium ion binding GO:0008199: ferric iron binding GO:0016493: C-C chemokine receptor activity GO:0015813: L-glutamate transport GO:0005504: fatty acid binding GO:0051539: 4 iron, 4 sulfur cluster binding GO:0004181: metallocarboxypeptidase activity GO:0032722: positive regulation of chemokine production GO:0006635: fatty acid beta-oxidation GO:0051046: regulation of secretion GO:0060087: relaxation of vascular smooth muscle GO:0046688: response to copper ion GO:0043588: skin development GO:0046873: metal ion transmembrane transporter activity GO:0008026: ATP-dependent helicase activity GO:0007341: penetration of zona pellucida GO:0032393: MHC class I receptor activity GO:0004866: endopeptidase inhibitor activity GO:0006207: 'de novo' pyrimidine base biosynthetic process GO:0009607: response to biotic stimulus GO:0006145: purine base catabolic process GO:0060173: limb development GO:0007254: JNK cascade GO:0006875: cellular metal ion homeostasis GO:0007612: learning GO:0007126: meiosis GO:0042355: L-fucose catabolic process GO:0004693: cyclin-dependent protein kinase activity GO:0006099: tricarboxylic acid cycle GO:0030048: actin filament-based movement GO:0030520: estrogen receptor signaling pathway GO:0016591: DNA-directed RNA polymerase II, holoenzyme GO:0017113: dihydropyrimidine dehydrogenase (NADP+) activity GO:0007598: blood coagulation, extrinsic pathway GO:0045919: positive regulation of cytolysis GO:0050783: cocaine metabolic process GO:0006880: intracellular sequestering of iron ion GO:0002526: acute inflammatory response GO:0035035: histone acetyltransferase binding GO:0048468: cell development GO:0000302: response to reactive oxygen species GO:0051607: defense response to virus GO:0007286: spermatid development GO:0004185: serine-type carboxypeptidase activity GO:0005375: copper ion transmembrane transporter activity GO:0042102: positive regulation of T cell proliferation GO:0015501: glutamate:sodium symporter activity GO:0001533: cornified envelope GO:0006541: glutamine metabolic process GO:0003785: actin monomer binding GO:0008510: sodium:bicarbonate symporter activity GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0003945: N-acetyllactosamine synthase activity GO:0019882: antigen processing and presentation GO:0008043: intracellular ferritin complex GO:0006783: heme biosynthetic process GO:0004158: dihydroorotate oxidase activity #1043IR #10IR 2 GO:0043410: positive regulation of MAPKKK cascade GO:0042301: phosphate binding #1051IR #10IR 15 GO:0008527: taste receptor activity GO:0001678: cellular glucose homeostasis GO:0035066: positive regulation of histone acetylation GO:0046321: positive regulation of fatty acid oxidation GO:0045333: cellular respiration GO:0050873: brown fat cell differentiation GO:0005665: DNA-directed RNA polymerase II, core complex GO:0001659: temperature homeostasis GO:0005001: transmembrane receptor protein tyrosine phosphatase activity GO:0022904: respiratory electron transport chain GO:0004114: 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0045295: gamma-catenin binding GO:0004949: cannabinoid receptor activity GO:0007610: behavior GO:0018149: peptide cross-linking #1063IR #10IR 506 GO:0048812: neuron projection morphogenesis GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0010759: positive regulation of macrophage chemotaxis GO:0060070: canonical Wnt receptor signaling pathway GO:0032094: response to food GO:0030247: polysaccharide binding GO:0018279: protein N-linked glycosylation via asparagine GO:0019807: aspartoacylase activity GO:0006939: smooth muscle contraction GO:0008398: sterol 14-demethylase activity GO:0030672: synaptic vesicle membrane GO:0019432: triglyceride biosynthetic process GO:0004903: growth hormone receptor activity GO:0002634: regulation of germinal center formation GO:0006928: cellular component movement GO:0006906: vesicle fusion GO:0060325: face morphogenesis GO:0048539: bone marrow development GO:0006325: chromatin organization GO:0017016: Ras GTPase binding GO:0035307: positive regulation of protein dephosphorylation GO:0008198: ferrous iron binding GO:0043101: purine-containing compound salvage GO:0042578: phosphoric ester hydrolase activity GO:0010553: negative regulation of gene-specific transcription from RNA polymerase II promoter GO:0071062: alphav-beta3 integrin-vitronectin complex GO:0005980: glycogen catabolic process GO:0007568: aging GO:0004833: tryptophan 2,3-dioxygenase activity GO:0001656: metanephros development GO:0021506: anterior neuropore closure GO:0050479: glyceryl-ether monooxygenase activity GO:0006569: tryptophan catabolic process GO:0050998: nitric-oxide synthase binding GO:0048514: blood vessel morphogenesis GO:0007517: muscle organ development GO:0050768: negative regulation of neurogenesis GO:0005901: caveola GO:0022409: positive regulation of cell-cell adhesion GO:0070836: caveola assembly GO:0002051: osteoblast fate commitment GO:0043966: histone H3 acetylation GO:0030177: positive regulation of Wnt receptor signaling pathway GO:0043403: skeletal muscle tissue regeneration GO:0070172: positive regulation of tooth mineralization GO:0002709: regulation of T cell mediated immunity GO:0002020: protease binding GO:0017154: semaphorin receptor activity GO:0010843: promoter binding GO:0004459: L-lactate dehydrogenase activity GO:0021766: hippocampus development GO:0004445: inositol-polyphosphate 5-phosphatase activity GO:0080025: phosphatidylinositol-3,5-bisphosphate binding GO:0017157: regulation of exocytosis GO:0006776: vitamin A metabolic process GO:0010596: negative regulation of endothelial cell migration GO:0001676: long-chain fatty acid metabolic process GO:0010951: negative regulation of endopeptidase activity GO:0030147: natriuresis GO:0045879: negative regulation of smoothened signaling pathway GO:0042936: dipeptide transporter activity GO:0045329: carnitine biosynthetic process GO:0034755: iron ion transmembrane transport GO:0004000: adenosine deaminase activity GO:0010936: negative regulation of macrophage cytokine production GO:0051591: response to cAMP GO:0014049: positive regulation of glutamate secretion GO:0004435: phosphatidylinositol phospholipase C activity GO:0005773: vacuole GO:0048312: intracellular distribution of mitochondria GO:0007274: neuromuscular synaptic transmission GO:0009168: purine ribonucleoside monophosphate biosynthetic process GO:0030902: hindbrain development GO:0050748: negative regulation of lipoprotein metabolic process GO:0090090: negative regulation of canonical Wnt receptor signaling pathway GO:0006351: transcription, DNA-dependent GO:0007044: cell-substrate junction assembly GO:0030133: transport vesicle GO:0000216: M/G1 transition of mitotic cell cycle GO:0032809: neuronal cell body membrane GO:0004336: galactosylceramidase activity GO:0070050: neuron homeostasis GO:0071320: cellular response to cAMP GO:0045124: regulation of bone resorption GO:0010524: positive regulation of calcium ion transport into cytosol GO:0043235: receptor complex GO:0043278: response to morphine GO:0006767: water-soluble vitamin metabolic process GO:0043097: pyrimidine nucleoside salvage GO:0033300: dehydroascorbic acid transporter activity GO:0021879: forebrain neuron differentiation GO:0032496: response to lipopolysaccharide GO:0016010: dystrophin-associated glycoprotein complex GO:0005262: calcium channel activity GO:0015267: channel activity GO:0090023: positive regulation of neutrophil chemotaxis GO:0030818: negative regulation of cAMP biosynthetic process GO:0070555: response to interleukin-1 GO:0003700: sequence-specific DNA binding transcription factor activity GO:0002090: regulation of receptor internalization GO:0051789: response to protein stimulus GO:0048661: positive regulation of smooth muscle cell proliferation GO:0032868: response to insulin stimulus GO:0046638: positive regulation of alpha-beta T cell differentiation GO:0050728: negative regulation of inflammatory response GO:0002021: response to dietary excess GO:0043679: axon terminus GO:0034138: toll-like receptor 3 signaling pathway GO:0060484: lung-associated mesenchyme development GO:0019442: tryptophan catabolic process to acetyl-CoA GO:0005154: epidermal growth factor receptor binding GO:0030667: secretory granule membrane GO:0031234: extrinsic to internal side of plasma membrane GO:0006066: alcohol metabolic process GO:0001934: positive regulation of protein phosphorylation GO:0006521: regulation of cellular amino acid metabolic process GO:0031995: insulin-like growth factor II binding GO:0006520: cellular amino acid metabolic process GO:0009166: nucleotide catabolic process GO:0032369: negative regulation of lipid transport GO:0051545: negative regulation of elastin biosynthetic process GO:0033555: multicellular organismal response to stress GO:0032026: response to magnesium ion GO:0010888: negative regulation of lipid storage GO:0055056: D-glucose transmembrane transporter activity GO:0016566: specific transcriptional repressor activity GO:0004943: C3a anaphylatoxin receptor activity GO:0000904: cell morphogenesis involved in differentiation GO:0007266: Rho protein signal transduction GO:0001958: endochondral ossification GO:0046545: development of primary female sexual characteristics GO:0016525: negative regulation of angiogenesis GO:0042166: acetylcholine binding GO:0043394: proteoglycan binding GO:0045596: negative regulation of cell differentiation GO:0005044: scavenger receptor activity GO:0048167: regulation of synaptic plasticity GO:0032755: positive regulation of interleukin-6 production GO:0055037: recycling endosome GO:0048487: beta-tubulin binding GO:0043526: neuroprotection GO:0090082: positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway GO:0005606: laminin-1 complex GO:0070491: repressing transcription factor binding GO:0005088: Ras guanyl-nucleotide exchange factor activity GO:0034372: very-low-density lipoprotein particle remodeling GO:0008645: hexose transport GO:0031258: lamellipodium membrane GO:0032526: response to retinoic acid GO:0051289: protein homotetramerization GO:0048786: presynaptic active zone GO:0034976: response to endoplasmic reticulum stress GO:0042923: neuropeptide binding GO:0043409: negative regulation of MAPKKK cascade GO:0033391: chromatoid body GO:0034599: cellular response to oxidative stress GO:0015250: water channel activity GO:0030901: midbrain development GO:0006090: pyruvate metabolic process GO:0060732: positive regulation of inositol phosphate biosynthetic process GO:0004876: complement component C3a receptor activity GO:0050918: positive chemotaxis GO:0071377: cellular response to glucagon stimulus GO:0031340: positive regulation of vesicle fusion GO:0044130: negative regulation of growth of symbiont in host GO:0042130: negative regulation of T cell proliferation GO:0051149: positive regulation of muscle cell differentiation GO:0006184: GTP catabolic process GO:0008336: gamma-butyrobetaine dioxygenase activity GO:0007416: synapse assembly GO:0006766: vitamin metabolic process GO:0032983: kainate selective glutamate receptor complex GO:0048630: skeletal muscle tissue growth GO:0007492: endoderm development GO:0055086: nucleobase, nucleoside and nucleotide metabolic process GO:0002430: complement receptor mediated signaling pathway GO:0001850: complement component C3a binding GO:0042692: muscle cell differentiation GO:0051897: positive regulation of protein kinase B signaling cascade GO:0014842: regulation of satellite cell proliferation GO:0006644: phospholipid metabolic process GO:0010002: cardioblast differentiation GO:0015732: prostaglandin transport GO:0001664: G-protein-coupled receptor binding GO:0003680: AT DNA binding GO:0042568: insulin-like growth factor binary complex GO:0016043: cellular component organization GO:0051259: protein oligomerization GO:0016311: dephosphorylation GO:0031781: type 3 melanocortin receptor binding GO:0051403: stress-activated MAPK cascade GO:0060055: angiogenesis involved in wound healing GO:0046898: response to cycloheximide GO:0048278: vesicle docking GO:0045332: phospholipid translocation GO:0050714: positive regulation of protein secretion GO:0006898: receptor-mediated endocytosis GO:0030819: positive regulation of cAMP biosynthetic process GO:0030301: cholesterol transport GO:0005502: 11-cis retinal binding GO:0048755: branching morphogenesis of a nerve GO:0006533: aspartate catabolic process GO:0014824: artery smooth muscle contraction GO:0001869: negative regulation of complement activation, lectin pathway GO:0034186: apolipoprotein A-I binding GO:0004806: triglyceride lipase activity GO:0015186: L-glutamine transmembrane transporter activity GO:0051234: establishment of localization GO:0045542: positive regulation of cholesterol biosynthetic process GO:0006730: one-carbon metabolic process GO:0004850: uridine phosphorylase activity GO:0060161: positive regulation of dopamine receptor signaling pathway GO:0030855: epithelial cell differentiation GO:0090050: positive regulation of cell migration involved in sprouting angiogenesis GO:0035583: negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta GO:0004620: phospholipase activity GO:0005902: microvillus GO:0050776: regulation of immune response GO:0034329: cell junction assembly GO:0007613: memory GO:0051593: response to folic acid GO:0015101: organic cation transmembrane transporter activity GO:0016044: cellular membrane organization GO:0050660: flavin adenine dinucleotide binding GO:0008081: phosphoric diester hydrolase activity GO:0045715: negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0060463: lung lobe morphogenesis GO:0042136: neurotransmitter biosynthetic process GO:0032760: positive regulation of tumor necrosis factor production GO:0030073: insulin secretion GO:0015132: prostaglandin transmembrane transporter activity GO:0006853: carnitine shuttle GO:0048566: embryonic digestive tract development GO:0046485: ether lipid metabolic process GO:0050804: regulation of synaptic transmission GO:0015035: protein disulfide oxidoreductase activity GO:0031333: negative regulation of protein complex assembly GO:0005614: interstitial matrix GO:0060337: type I interferon-mediated signaling pathway GO:0008643: carbohydrate transport GO:0048839: inner ear development GO:0022891: substrate-specific transmembrane transporter activity GO:0005545: 1-phosphatidylinositol binding GO:0008543: fibroblast growth factor receptor signaling pathway GO:0060346: bone trabecula formation GO:0031224: intrinsic to membrane GO:0055114: oxidation-reduction process GO:0001933: negative regulation of protein phosphorylation GO:0007088: regulation of mitosis GO:0002092: positive regulation of receptor internalization GO:0050891: multicellular organismal water homeostasis GO:0043014: alpha-tubulin binding GO:0042567: insulin-like growth factor ternary complex GO:0001569: patterning of blood vessels GO:0016597: amino acid binding GO:0090303: positive regulation of wound healing GO:0006486: protein glycosylation GO:0010552: positive regulation of gene-specific transcription from RNA polymerase II promoter GO:0035115: embryonic forelimb morphogenesis GO:0009755: hormone-mediated signaling pathway GO:0006069: ethanol oxidation GO:0003987: acetate-CoA ligase activity GO:0002040: sprouting angiogenesis GO:0033267: axon part GO:0042637: catagen GO:0042895: antibiotic transporter activity GO:0035116: embryonic hindlimb morphogenesis GO:0007193: inhibition of adenylate cyclase activity by G-protein signaling pathway GO:0001527: microfibril GO:0030673: axolemma GO:0051482: elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger GO:0060174: limb bud formation GO:0009117: nucleotide metabolic process GO:0046135: pyrimidine nucleoside catabolic process GO:0046427: positive regulation of JAK-STAT cascade GO:0007512: adult heart development GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0047498: calcium-dependent phospholipase A2 activity GO:0031398: positive regulation of protein ubiquitination GO:0060445: branching involved in salivary gland morphogenesis GO:0046426: negative regulation of JAK-STAT cascade GO:0045671: negative regulation of osteoclast differentiation GO:0051781: positive regulation of cell division GO:0035313: wound healing, spreading of epidermal cells GO:0032582: negative regulation of gene-specific transcription GO:0046209: nitric oxide metabolic process GO:0005791: rough endoplasmic reticulum GO:0070935: 3'-UTR-mediated mRNA stabilization GO:0019841: retinol binding GO:0008202: steroid metabolic process GO:0009952: anterior/posterior pattern formation GO:0006468: protein phosphorylation GO:0017075: syntaxin-1 binding GO:0034220: ion transmembrane transport GO:0001701: in utero embryonic development GO:0031115: negative regulation of microtubule polymerization GO:0008063: Toll signaling pathway GO:0005626: insoluble fraction GO:0014070: response to organic cyclic compound GO:0031782: type 4 melanocortin receptor binding GO:0051205: protein insertion into membrane GO:0010243: response to organic nitrogen GO:0000209: protein polyubiquitination GO:0005921: gap junction GO:0016079: synaptic vesicle exocytosis GO:0045885: positive regulation of survival gene product expression GO:0005242: inward rectifier potassium channel activity GO:0030278: regulation of ossification GO:0034707: chloride channel complex GO:0019433: triglyceride catabolic process GO:0043084: penile erection GO:0050830: defense response to Gram-positive bacterium GO:0008528: peptide receptor activity, G-protein coupled GO:0055065: metal ion homeostasis GO:0010037: response to carbon dioxide GO:0070588: calcium ion transmembrane transport GO:0007597: blood coagulation, intrinsic pathway GO:0070837: dehydroascorbic acid transport GO:0004999: vasoactive intestinal polypeptide receptor activity GO:0034134: toll-like receptor 2 signaling pathway GO:0002686: negative regulation of leukocyte migration GO:0046855: inositol phosphate dephosphorylation GO:0043691: reverse cholesterol transport GO:0000786: nucleosome GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis GO:0001944: vasculature development GO:0002224: toll-like receptor signaling pathway GO:0008160: protein tyrosine phosphatase activator activity GO:0034332: adherens junction organization GO:0015030: Cajal body GO:0048706: embryonic skeletal system development GO:0030665: clathrin coated vesicle membrane GO:0009268: response to pH GO:0016941: natriuretic peptide receptor activity GO:0004383: guanylate cyclase activity GO:0033137: negative regulation of peptidyl-serine phosphorylation GO:0031315: extrinsic to mitochondrial outer membrane GO:0006154: adenosine catabolic process GO:0006921: cellular component disassembly involved in apoptosis GO:0004029: aldehyde dehydrogenase (NAD) activity GO:0045765: regulation of angiogenesis GO:0009790: embryo development GO:0034142: toll-like receptor 4 signaling pathway GO:0070256: negative regulation of mucus secretion GO:0090263: positive regulation of canonical Wnt receptor signaling pathway GO:0031783: type 5 melanocortin receptor binding GO:0010842: retina layer formation GO:0042393: histone binding GO:0017091: AU-rich element binding GO:0030514: negative regulation of BMP signaling pathway GO:0006527: arginine catabolic process GO:0010745: negative regulation of macrophage derived foam cell differentiation GO:0016529: sarcoplasmic reticulum GO:0042220: response to cocaine GO:0070365: hepatocyte differentiation GO:0016328: lateral plasma membrane GO:0034375: high-density lipoprotein particle remodeling GO:0046847: filopodium assembly GO:0005372: water transmembrane transporter activity GO:0060666: dichotomous subdivision of terminal units involved in salivary gland branching GO:0050678: regulation of epithelial cell proliferation GO:0051549: positive regulation of keratinocyte migration GO:0045663: positive regulation of myoblast differentiation GO:0033144: negative regulation of steroid hormone receptor signaling pathway GO:0051924: regulation of calcium ion transport GO:0005881: cytoplasmic microtubule GO:0006182: cGMP biosynthetic process GO:0007184: SMAD protein import into nucleus GO:0051928: positive regulation of calcium ion transport GO:0035050: embryonic heart tube development GO:0002576: platelet degranulation GO:0055085: transmembrane transport GO:0048701: embryonic cranial skeleton morphogenesis GO:0048843: negative regulation of axon extension involved in axon guidance GO:0004030: aldehyde dehydrogenase [NAD(P)+] activity GO:0048014: Tie receptor signaling pathway GO:0019534: toxin transporter activity GO:0045844: positive regulation of striated muscle tissue development GO:0006206: pyrimidine base metabolic process GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0002070: epithelial cell maturation GO:0004115: 3',5'-cyclic-AMP phosphodiesterase activity GO:0005083: small GTPase regulator activity GO:0055091: phospholipid homeostasis GO:0015867: ATP transport GO:0014032: neural crest cell development GO:0031748: D1 dopamine receptor binding GO:0032580: Golgi cisterna membrane GO:0015758: glucose transport GO:0070207: protein homotrimerization GO:0032332: positive regulation of chondrocyte differentiation GO:0019441: tryptophan catabolic process to kynurenine GO:0050679: positive regulation of epithelial cell proliferation GO:0030850: prostate gland development GO:0042487: regulation of odontogenesis of dentine-containing tooth GO:0030136: clathrin-coated vesicle GO:0003333: amino acid transmembrane transport GO:0014069: postsynaptic density GO:0007168: receptor guanylyl cyclase signaling pathway GO:0070742: C2H2 zinc finger domain binding GO:0060916: mesenchymal cell proliferation involved in lung development GO:0008179: adenylate cyclase binding GO:0007029: endoplasmic reticulum organization GO:0031622: positive regulation of fever generation GO:0060548: negative regulation of cell death GO:0014909: smooth muscle cell migration GO:0060351: cartilage development involved in endochondral bone morphogenesis GO:0030414: peptidase inhibitor activity GO:0034641: cellular nitrogen compound metabolic process GO:0010232: vascular transport GO:0000922: spindle pole GO:0060348: bone development GO:0001599: endothelin-A receptor activity GO:0035295: tube development GO:0046108: uridine metabolic process GO:0002053: positive regulation of mesenchymal cell proliferation GO:0070295: renal water absorption GO:0019905: syntaxin binding GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0007166: cell surface receptor linked signaling pathway GO:0001649: osteoblast differentiation GO:0070083: clathrin sculpted monoamine transport vesicle membrane GO:0048557: embryonic digestive tract morphogenesis GO:0031960: response to corticosteroid stimulus GO:0060416: response to growth hormone stimulus GO:0040036: regulation of fibroblast growth factor receptor signaling pathway GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0030141: stored secretory granule GO:0007162: negative regulation of cell adhesion GO:0001883: purine nucleoside binding GO:0006144: purine base metabolic process GO:0055093: response to hyperoxia GO:0030057: desmosome GO:0046716: muscle cell homeostasis GO:0010629: negative regulation of gene expression GO:0031625: ubiquitin protein ligase binding GO:0007398: ectoderm development GO:0043237: laminin-1 binding GO:0071438: invadopodium membrane GO:0050750: low-density lipoprotein particle receptor binding GO:0048568: embryonic organ development GO:0010595: positive regulation of endothelial cell migration GO:0005184: neuropeptide hormone activity GO:0071398: cellular response to fatty acid GO:0034199: activation of protein kinase A activity GO:0010466: negative regulation of peptidase activity GO:0006833: water transport GO:0010628: positive regulation of gene expression GO:0042277: peptide binding GO:0010811: positive regulation of cell-substrate adhesion GO:0010716: negative regulation of extracellular matrix disassembly GO:0033574: response to testosterone stimulus GO:0015695: organic cation transport GO:0001657: ureteric bud development GO:0033089: positive regulation of T cell differentiation in thymus GO:0044255: cellular lipid metabolic process GO:0030210: heparin biosynthetic process GO:0031594: neuromuscular junction GO:0030325: adrenal gland development GO:0004439: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0003007: heart morphogenesis GO:0042787: protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0060333: interferon-gamma-mediated signaling pathway GO:0030501: positive regulation of bone mineralization GO:0046856: phosphatidylinositol dephosphorylation GO:0005546: phosphatidylinositol-4,5-bisphosphate binding GO:0034704: calcium channel complex GO:0005811: lipid particle GO:0019800: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan GO:0043010: camera-type eye development GO:0019933: cAMP-mediated signaling GO:0035556: intracellular signal transduction GO:0009954: proximal/distal pattern formation GO:0005539: glycosaminoglycan binding GO:0004175: endopeptidase activity GO:0050881: musculoskeletal movement GO:0002063: chondrocyte development GO:0031092: platelet alpha granule membrane GO:0048019: receptor antagonist activity GO:0017137: Rab GTPase binding GO:0043190: ATP-binding cassette (ABC) transporter complex GO:0043116: negative regulation of vascular permeability GO:0004465: lipoprotein lipase activity GO:0045216: cell-cell junction organization GO:0031175: neuron projection development GO:0071346: cellular response to interferon-gamma GO:0042562: hormone binding GO:0003705: sequence-specific enhancer binding RNA polymerase II transcription factor activity GO:0048870: cell motility GO:0060523: prostate epithelial cord elongation GO:0031780: adrenocorticotropin hormone receptor binding GO:0006683: galactosylceramide catabolic process GO:0005243: gap junction channel activity GO:0090244: Wnt receptor signaling pathway involved in somitogenesis GO:0005355: glucose transmembrane transporter activity GO:0070996: type 1 melanocortin receptor binding GO:0004962: endothelin receptor activity GO:0034130: toll-like receptor 1 signaling pathway GO:0051281: positive regulation of release of sequestered calcium ion into cytosol GO:0050955: thermoception GO:0006012: galactose metabolic process GO:0043025: neuronal cell body GO:0051602: response to electrical stimulus GO:0042383: sarcolemma GO:0043252: sodium-independent organic anion transport #1043IR #1095IR 12 GO:0018345: protein palmitoylation GO:0032281: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex GO:0030641: regulation of cellular pH GO:0005372: water transporter activity GO:0001887: selenium metabolic process GO:0015077: monovalent inorganic cation transmembrane transporter activity GO:0008889: glycerophosphodiester phosphodiesterase activity GO:0019992: diacylglycerol binding GO:0016409: palmitoyltransferase activity GO:0030317: sperm motility GO:0005890: sodium:potassium-exchanging ATPase complex GO:0006942: regulation of striated muscle contraction #1051IR #1095IR 38 GO:0048154: S100 beta binding GO:0055114: oxidation reduction GO:0003700: transcription factor activity GO:0008109: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity GO:0042801: polo kinase kinase activity GO:0006944: membrane fusion GO:0008037: cell recognition GO:0050660: FAD binding GO:0034614: cellular response to reactive oxygen species GO:0034644: cellular response to UV GO:0007338: single fertilization GO:0006497: protein amino acid lipidation GO:0005545: phosphatidylinositol binding GO:0048066: pigmentation during development GO:0006957: complement activation, alternative pathway GO:0007497: posterior midgut development GO:0006486: protein amino acid glycosylation GO:0007517: muscle development GO:0006468: protein amino acid phosphorylation GO:0030594: neurotransmitter receptor activity GO:0030286: dynein complex GO:0042953: lipoprotein transport GO:0015662: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0031953: negative regulation of protein amino acid autophosphorylation GO:0006350: transcription GO:0046777: protein amino acid autophosphorylation GO:0006470: protein amino acid dephosphorylation GO:0005005: transmembrane-ephrin receptor activity GO:0000775: chromosome, centromeric region GO:0007416: synaptogenesis GO:0019941: modification-dependent protein catabolic process GO:0030866: cortical actin cytoskeleton organization GO:0004653: polypeptide N-acetylgalactosaminyltransferase activity GO:0001816: cytokine production GO:0042598: vesicular fraction GO:0004864: phosphoprotein phosphatase inhibitor activity GO:0004411: homogentisate 1,2-dioxygenase activity GO:0006024: glycosaminoglycan biosynthetic process #1063IR #1095IR 202 GO:0007089: traversing start control point of mitotic cell cycle GO:0003697: single-stranded DNA binding GO:0048245: eosinophil chemotaxis GO:0010033: response to organic substance GO:0019900: kinase binding GO:0009987: cellular process GO:0005796: Golgi lumen GO:0070309: lens fiber cell morphogenesis GO:0003690: double-stranded DNA binding GO:0004860: protein kinase inhibitor activity GO:0008242: omega peptidase activity GO:0021952: central nervous system projection neuron axonogenesis GO:0014059: regulation of dopamine secretion GO:0007176: regulation of epidermal growth factor receptor activity GO:0017147: Wnt-protein binding GO:0008584: male gonad development GO:0016327: apicolateral plasma membrane GO:0050860: negative regulation of T cell receptor signaling pathway GO:0048845: venous blood vessel morphogenesis GO:0050662: coenzyme binding GO:0008467: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity GO:0051537: 2 iron, 2 sulfur cluster binding GO:0045182: translation regulator activity GO:0021680: cerebellar Purkinje cell layer development GO:0006690: icosanoid metabolic process GO:0035162: embryonic hemopoiesis GO:0050659: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity GO:0007566: embryo implantation GO:0021987: cerebral cortex development GO:0019915: lipid storage GO:0004879: ligand-dependent nuclear receptor activity GO:0001508: regulation of action potential GO:0032839: dendrite cytoplasm GO:0005042: netrin receptor activity GO:0042246: tissue regeneration GO:0042989: sequestering of actin monomers GO:0030968: endoplasmic reticulum unfolded protein response GO:0008234: cysteine-type peptidase activity GO:0005740: mitochondrial envelope GO:0006310: DNA recombination GO:0007595: lactation GO:0015914: phospholipid transport GO:0060298: positive regulation of sarcomere organization GO:0000718: nucleotide-excision repair, DNA damage removal GO:0048037: cofactor binding GO:0045737: positive regulation of cyclin-dependent protein kinase activity GO:0009313: oligosaccharide catabolic process GO:0051233: spindle midzone GO:0050699: WW domain binding GO:0009306: protein secretion GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0001974: blood vessel remodeling GO:0050730: regulation of peptidyl-tyrosine phosphorylation GO:0008585: female gonad development GO:0005100: Rho GTPase activator activity GO:0016853: isomerase activity GO:0007599: hemostasis GO:0032312: regulation of ARF GTPase activity GO:0043122: regulation of I-kappaB kinase/NF-kappaB cascade GO:0006302: double-strand break repair GO:0043407: negative regulation of MAP kinase activity GO:0001890: placenta development GO:0006412: translation GO:0048027: mRNA 5'-UTR binding GO:0001725: stress fiber GO:0016049: cell growth GO:0031667: response to nutrient levels GO:0060042: retina morphogenesis in camera-type eye GO:0050811: GABA receptor binding GO:0009566: fertilization GO:0060214: endocardium formation GO:0015026: coreceptor activity GO:0015807: L-amino acid transport GO:0001756: somitogenesis GO:0005095: GTPase inhibitor activity GO:0030246: carbohydrate binding GO:0043406: positive regulation of MAP kinase activity GO:0008466: glycogenin glucosyltransferase activity GO:0006297: nucleotide-excision repair, DNA gap filling GO:0046620: regulation of organ growth GO:0048012: hepatocyte growth factor receptor signaling pathway GO:0005484: SNAP receptor activity GO:0021516: dorsal spinal cord development GO:0009410: response to xenobiotic stimulus GO:0008156: negative regulation of DNA replication GO:0031072: heat shock protein binding GO:0060009: Sertoli cell development GO:0007628: adult walking behavior GO:0005782: peroxisomal matrix GO:0006491: N-glycan processing GO:0032947: protein complex scaffold GO:0045768: positive regulation of anti-apoptosis GO:0004527: exonuclease activity GO:0006914: autophagy GO:0008060: ARF GTPase activator activity GO:0042789: mRNA transcription from RNA polymerase II promoter GO:0008654: phospholipid biosynthetic process GO:0047485: protein N-terminus binding GO:0009437: carnitine metabolic process GO:0005008: hepatocyte growth factor receptor activity GO:0004221: ubiquitin thiolesterase activity GO:0030276: clathrin binding GO:0018298: protein-chromophore linkage GO:0000036: acyl carrier activity GO:0030504: inorganic diphosphate transmembrane transporter activity GO:0006820: anion transport GO:0015015: heparan sulfate proteoglycan biosynthetic process, enzymatic modification GO:0004519: endonuclease activity GO:0031201: SNARE complex GO:0015271: outward rectifier potassium channel activity GO:0005978: glycogen biosynthetic process GO:0045351: type I interferon biosynthetic process GO:0030910: olfactory placode formation GO:0016758: transferase activity, transferring hexosyl groups GO:0019674: NAD metabolic process GO:0000723: telomere maintenance GO:0015459: potassium channel regulator activity GO:0016579: protein deubiquitination GO:0009058: biosynthetic process GO:0042326: negative regulation of phosphorylation GO:0004571: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0042133: neurotransmitter metabolic process GO:0043049: otic placode formation GO:0001709: cell fate determination GO:0016790: thiolester hydrolase activity GO:0008210: estrogen metabolic process GO:0003955: NAD(P)H dehydrogenase (quinone) activity GO:0050930: induction of positive chemotaxis GO:0015923: mannosidase activity GO:0001568: blood vessel development GO:0030532: small nuclear ribonucleoprotein complex GO:0042056: chemoattractant activity GO:0033872: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity GO:0060041: retina development in camera-type eye GO:0008191: metalloendopeptidase inhibitor activity GO:0005819: spindle GO:0016538: cyclin-dependent protein kinase regulator activity GO:0046329: negative regulation of JNK cascade GO:0021522: spinal cord motor neuron differentiation GO:0007269: neurotransmitter secretion GO:0006516: glycoprotein catabolic process GO:0005884: actin filament GO:0016605: PML body GO:0019319: hexose biosynthetic process GO:0004869: cysteine-type endopeptidase inhibitor activity GO:0032940: secretion by cell GO:0021702: cerebellar Purkinje cell differentiation GO:0051879: Hsp90 protein binding GO:0019864: IgG binding GO:0004128: cytochrome-b5 reductase activity GO:0000076: DNA replication checkpoint GO:0003950: NAD+ ADP-ribosyltransferase activity GO:0005801: cis-Golgi network GO:0008218: bioluminescence GO:0008503: benzodiazepine receptor activity GO:0003993: acid phosphatase activity GO:0019896: axon transport of mitochondrion GO:0006665: sphingolipid metabolic process GO:0047391: alkylglycerophosphoethanolamine phosphodiesterase activity GO:0042813: Wnt receptor activity GO:0030509: BMP signaling pathway GO:0000118: histone deacetylase complex GO:0005519: cytoskeletal regulatory protein binding GO:0021915: neural tube development GO:0019079: viral genome replication GO:0016126: sterol biosynthetic process GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds GO:0045807: positive regulation of endocytosis GO:0015179: L-amino acid transmembrane transporter activity GO:0060076: excitatory synapse GO:0042035: regulation of cytokine biosynthetic process GO:0050885: neuromuscular process controlling balance GO:0008565: protein transporter activity GO:0035264: multicellular organism growth GO:0032769: negative regulation of monooxygenase activity GO:0019956: chemokine binding GO:0034341: response to interferon-gamma GO:0046928: regulation of neurotransmitter secretion GO:0017053: transcriptional repressor complex GO:0005315: inorganic phosphate transmembrane transporter activity GO:0009311: oligosaccharide metabolic process GO:0048511: rhythmic process GO:0016197: endosome transport GO:0004683: calmodulin-dependent protein kinase activity GO:0000151: ubiquitin ligase complex GO:0004721: phosphoprotein phosphatase activity GO:0055005: ventricular cardiac myofibril development GO:0007412: axon target recognition GO:0006289: nucleotide-excision repair GO:0008379: thioredoxin peroxidase activity GO:0004622: lysophospholipase activity GO:0006044: N-acetylglucosamine metabolic process GO:0001504: neurotransmitter uptake GO:0048247: lymphocyte chemotaxis GO:0051045: negative regulation of membrane protein ectodomain proteolysis GO:0008354: germ cell migration GO:0004091: carboxylesterase activity GO:0042744: hydrogen peroxide catabolic process GO:0060048: cardiac muscle contraction GO:0019867: outer membrane GO:0043205: fibril GO:0009925: basal plasma membrane #1051IR #1063IR 10 GO:0016308: 1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0048156: tau protein binding GO:0031018: endocrine pancreas development GO:0005898: interleukin-13 receptor complex GO:0032092: positive regulation of protein binding GO:0005596: collagen type XIV GO:0048814: regulation of dendrite morphogenesis GO:0014056: regulation of acetylcholine secretion GO:0045210: FasL biosynthetic process GO:0001822: kidney development #10IR 571 GO:0008475: procollagen-lysine 5-dioxygenase activity GO:0032318: regulation of Ras GTPase activity GO:0006208: pyrimidine base catabolic process GO:0045995: regulation of embryonic development GO:0031849: olfactory receptor binding GO:0001841: neural tube formation GO:0032757: positive regulation of interleukin-8 production GO:0005913: cell-cell adherens junction GO:0016071: mRNA metabolic process GO:0032714: negative regulation of interleukin-5 production GO:0071565: nBAF complex GO:0045909: positive regulation of vasodilation GO:0032376: positive regulation of cholesterol transport GO:0030957: Tat protein binding GO:0007502: digestive tract mesoderm development GO:0045785: positive regulation of cell adhesion GO:0032420: stereocilium GO:0034993: SUN-KASH complex GO:0071285: cellular response to lithium ion GO:0005220: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0035590: purinergic nucleotide receptor signaling pathway GO:0010976: positive regulation of neuron projection development GO:0048625: myoblast cell fate commitment GO:0031683: G-protein beta/gamma-subunit complex binding GO:0070826: paraferritin complex GO:0016051: carbohydrate biosynthetic process GO:0051495: positive regulation of cytoskeleton organization GO:0007250: activation of NF-kappaB-inducing kinase activity GO:2000062: negative regulation of ureter smooth muscle cell differentiation GO:0031313: extrinsic to endosome membrane GO:0050434: positive regulation of viral transcription GO:0016595: glutamate binding GO:0015238: drug transmembrane transporter activity GO:0060046: regulation of acrosome reaction GO:0031095: platelet dense tubular network membrane GO:0031090: organelle membrane GO:0016540: protein autoprocessing GO:0060662: salivary gland cavitation GO:0001574: ganglioside biosynthetic process GO:0060405: regulation of penile erection GO:0043132: NAD transport GO:0021882: regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment GO:0019985: translesion synthesis GO:0048844: artery morphogenesis GO:0030151: molybdenum ion binding GO:0048859: formation of anatomical boundary GO:0031094: platelet dense tubular network GO:0021940: positive regulation of cerebellar granule cell precursor proliferation GO:0004461: lactose synthase activity GO:0051209: release of sequestered calcium ion into cytosol GO:0009101: glycoprotein biosynthetic process GO:0060782: regulation of mesenchymal cell proliferation involved in prostate gland development GO:0010288: response to lead ion GO:0022602: ovulation cycle process GO:0001916: positive regulation of T cell mediated cytotoxicity GO:0014902: myotube differentiation GO:0008269: JAK pathway signal transduction adaptor activity GO:0043369: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment GO:0005989: lactose biosynthetic process GO:0003214: cardiac left ventricle morphogenesis GO:0071421: manganese ion transmembrane transport GO:0070447: positive regulation of oligodendrocyte progenitor proliferation GO:0030331: estrogen receptor binding GO:0030854: positive regulation of granulocyte differentiation GO:0015295: solute:hydrogen symporter activity GO:0070682: proteasome regulatory particle assembly GO:2000114: regulation of establishment of cell polarity GO:0051901: positive regulation of mitochondrial depolarization GO:0007340: acrosome reaction GO:0034141: positive regulation of toll-like receptor 3 signaling pathway GO:0034364: high-density lipoprotein particle GO:0045741: positive regulation of epidermal growth factor receptor activity GO:0046578: regulation of Ras protein signal transduction GO:0030332: cyclin binding GO:0021893: cerebral cortex GABAergic interneuron fate commitment GO:0045727: positive regulation of translation GO:0070574: cadmium ion transmembrane transport GO:0046686: response to cadmium ion GO:0031572: G2/M transition DNA damage checkpoint GO:0042733: embryonic digit morphogenesis GO:0005814: centriole GO:0004087: carbamoyl-phosphate synthase (ammonia) activity GO:0032000: positive regulation of fatty acid beta-oxidation GO:0032229: negative regulation of synaptic transmission, GABAergic GO:0051001: negative regulation of nitric-oxide synthase activity GO:0042489: negative regulation of odontogenesis of dentine-containing tooth GO:0030274: LIM domain binding GO:0033017: sarcoplasmic reticulum membrane GO:0031214: biomineral tissue development GO:0006801: superoxide metabolic process GO:0010042: response to manganese ion GO:0016925: protein sumoylation GO:0032648: regulation of interferon-beta production GO:0051938: L-glutamate import GO:0009331: glycerol-3-phosphate dehydrogenase complex GO:0070053: thrombospondin receptor activity GO:0006196: AMP catabolic process GO:0071223: cellular response to lipoteichoic acid GO:0055072: iron ion homeostasis GO:0003727: single-stranded RNA binding GO:0031999: negative regulation of fatty acid beta-oxidation GO:0016524: latrotoxin receptor activity GO:0035253: ciliary rootlet GO:0051496: positive regulation of stress fiber assembly GO:0071864: positive regulation of cell proliferation in bone marrow GO:0016316: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity GO:0051894: positive regulation of focal adhesion assembly GO:0005639: integral to nuclear inner membrane GO:0045759: negative regulation of action potential GO:0050715: positive regulation of cytokine secretion GO:0071866: negative regulation of apoptosis in bone marrow GO:0006349: regulation of gene expression by genetic imprinting GO:0045136: development of secondary sexual characteristics GO:0040038: polar body extrusion after meiotic divisions GO:0005313: L-glutamate transmembrane transporter activity GO:0030388: fructose 1,6-bisphosphate metabolic process GO:0015085: calcium ion transmembrane transporter activity GO:0050829: defense response to Gram-negative bacterium GO:2000343: positive regulation of chemokine (C-X-C motif) ligand 2 production GO:0070409: carbamoyl phosphate biosynthetic process GO:0005113: patched binding GO:0005351: sugar:hydrogen symporter activity GO:0018119: peptidyl-cysteine S-nitrosylation GO:0034618: arginine binding GO:0042153: RPTP-like protein binding GO:0030155: regulation of cell adhesion GO:0004368: glycerol-3-phosphate dehydrogenase activity GO:0005795: Golgi stack GO:0008253: 5'-nucleotidase activity GO:0005094: Rho GDP-dissociation inhibitor activity GO:0016528: sarcoplasm GO:0015676: vanadium ion transport GO:0042098: T cell proliferation GO:0015631: tubulin binding GO:0004499: flavin-containing monooxygenase activity GO:0060439: trachea morphogenesis GO:0015100: vanadium ion transmembrane transporter activity GO:0015299: solute:hydrogen antiporter activity GO:0007228: positive regulation of hh target transcription factor activity GO:0043923: positive regulation by host of viral transcription GO:0035434: copper ion transmembrane transport GO:0031953: negative regulation of protein autophosphorylation GO:0046685: response to arsenic-containing substance GO:0048715: negative regulation of oligodendrocyte differentiation GO:0004835: tubulin-tyrosine ligase activity GO:0006004: fucose metabolic process GO:0006956: complement activation GO:0071548: response to dexamethasone stimulus GO:0016151: nickel ion binding GO:0045880: positive regulation of smoothened signaling pathway GO:0090022: regulation of neutrophil chemotaxis GO:0006651: diacylglycerol biosynthetic process GO:0005104: fibroblast growth factor receptor binding GO:0031981: nuclear lumen GO:0070679: inositol 1,4,5 trisphosphate binding GO:0046168: glycerol-3-phosphate catabolic process GO:0042178: xenobiotic catabolic process GO:0001660: fever generation GO:0007494: midgut development GO:0014043: negative regulation of neuron maturation GO:0035444: nickel ion transmembrane transport GO:0030131: clathrin adaptor complex GO:0050482: arachidonic acid secretion GO:0032993: protein-DNA complex GO:0061056: sclerotome development GO:0048592: eye morphogenesis GO:0090068: positive regulation of cell cycle process GO:0060783: mesenchymal smoothened signaling pathway involved in prostate gland development GO:2000357: negative regulation of kidney smooth muscle cell differentiation GO:0002793: positive regulation of peptide secretion GO:0035663: Toll-like receptor 2 binding GO:0007224: smoothened signaling pathway GO:0007132: meiotic metaphase I GO:0060406: positive regulation of penile erection GO:0015884: folic acid transport GO:0006972: hyperosmotic response GO:0045178: basal part of cell GO:0050717: positive regulation of interleukin-1 alpha secretion GO:0006649: phospholipid transfer to membrane GO:0046888: negative regulation of hormone secretion GO:0006868: glutamine transport GO:0004607: phosphatidylcholine-sterol O-acyltransferase activity GO:0060259: regulation of feeding behavior GO:0034501: protein localization to kinetochore GO:0032060: bleb assembly GO:0032348: negative regulation of aldosterone biosynthetic process GO:0043032: positive regulation of macrophage activation GO:0032224: positive regulation of synaptic transmission, cholinergic GO:0035326: enhancer binding GO:0060025: regulation of synaptic activity GO:0001658: branching involved in ureteric bud morphogenesis GO:0060428: lung epithelium development GO:0051155: positive regulation of striated muscle cell differentiation GO:0016628: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0004560: alpha-L-fucosidase activity GO:0009411: response to UV GO:0005610: laminin-5 complex GO:0043236: laminin binding GO:0010039: response to iron ion GO:0060458: right lung development GO:0060135: maternal process involved in female pregnancy GO:0007097: nuclear migration GO:0008417: fucosyltransferase activity GO:0006930: substrate-dependent cell migration, cell extension GO:0033004: negative regulation of mast cell activation GO:0048738: cardiac muscle tissue development GO:0048714: positive regulation of oligodendrocyte differentiation GO:0022408: negative regulation of cell-cell adhesion GO:0046639: negative regulation of alpha-beta T cell differentiation GO:0072568: protein kinase C delta binding GO:0035091: phosphatidylinositol binding GO:0032738: positive regulation of interleukin-15 production GO:0030049: muscle filament sliding GO:0001759: organ induction GO:0003990: acetylcholinesterase activity GO:0003032: detection of oxygen GO:0003093: regulation of glomerular filtration GO:0016344: meiotic chromosome movement towards spindle pole GO:0015116: sulfate transmembrane transporter activity GO:0050031: L-pipecolate oxidase activity GO:0050995: negative regulation of lipid catabolic process GO:0045652: regulation of megakaryocyte differentiation GO:0003407: neural retina development GO:0008272: sulfate transport GO:0016539: intein-mediated protein splicing GO:0007009: plasma membrane organization GO:0030030: cell projection organization GO:0031668: cellular response to extracellular stimulus GO:0006828: manganese ion transport GO:0042323: negative regulation of circadian sleep/wake cycle, non-REM sleep GO:0004950: chemokine receptor activity GO:0006884: cell volume homeostasis GO:0030284: estrogen receptor activity GO:0033198: response to ATP GO:0045059: positive thymic T cell selection GO:0015093: ferrous iron transmembrane transporter activity GO:0045822: negative regulation of heart contraction GO:0016514: SWI/SNF complex GO:0051712: positive regulation of killing of cells of other organism GO:0045777: positive regulation of blood pressure GO:0033077: T cell differentiation in thymus GO:0044429: mitochondrial part GO:0042742: defense response to bacterium GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0014732: skeletal muscle atrophy GO:0005640: nuclear outer membrane GO:0005588: collagen type V GO:0004367: glycerol-3-phosphate dehydrogenase [NAD+] activity GO:0031022: nuclear migration along microfilament GO:0045776: negative regulation of blood pressure GO:0009953: dorsal/ventral pattern formation GO:0042474: middle ear morphogenesis GO:0030126: COPI vesicle coat GO:0005384: manganese ion transmembrane transporter activity GO:0048617: embryonic foregut morphogenesis GO:0008209: androgen metabolic process GO:0001955: blood vessel maturation GO:0000185: activation of MAPKKK activity GO:0046534: positive regulation of photoreceptor cell differentiation GO:0034123: positive regulation of toll-like receptor signaling pathway GO:0006839: mitochondrial transport GO:0048771: tissue remodeling GO:0004332: fructose-bisphosphate aldolase activity GO:0033265: choline binding GO:0050718: positive regulation of interleukin-1 beta secretion GO:0001614: purinergic nucleotide receptor activity GO:0060738: epithelial-mesenchymal signaling involved in prostate gland development GO:0008353: RNA polymerase II carboxy-terminal domain kinase activity GO:0045779: negative regulation of bone resorption GO:0006900: membrane budding GO:0007217: tachykinin receptor signaling pathway GO:0004931: extracellular ATP-gated cation channel activity GO:0032308: positive regulation of prostaglandin secretion GO:0045109: intermediate filament organization GO:0006259: DNA metabolic process GO:0070097: delta-catenin binding GO:0090073: positive regulation of protein homodimerization activity GO:0001708: cell fate specification GO:0008504: monoamine transmembrane transporter activity GO:0060586: multicellular organismal iron ion homeostasis GO:0051967: negative regulation of synaptic transmission, glutamatergic GO:0005148: prolactin receptor binding GO:0047496: vesicle transport along microtubule GO:0032728: positive regulation of interferon-beta production GO:0048645: organ formation GO:0045359: positive regulation of interferon-beta biosynthetic process GO:0046486: glycerolipid metabolic process GO:0030658: transport vesicle membrane GO:0015385: sodium:hydrogen antiporter activity GO:0004301: epoxide hydrolase activity GO:0051287: NAD binding GO:0021978: telencephalon regionalization GO:0010467: gene expression GO:0001845: phagolysosome assembly GO:0005903: brush border GO:0007520: myoblast fusion GO:0045410: positive regulation of interleukin-6 biosynthetic process GO:0030035: microspike assembly GO:0021772: olfactory bulb development GO:0048016: inositol phosphate-mediated signaling GO:0032228: regulation of synaptic transmission, GABAergic GO:0060020: Bergmann glial cell differentiation GO:0060054: positive regulation of epithelial cell proliferation involved in wound healing GO:0021521: ventral spinal cord interneuron specification GO:0034339: regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor GO:0044325: ion channel binding GO:0015180: L-alanine transmembrane transporter activity GO:0090197: positive regulation of chemokine secretion GO:0055038: recycling endosome membrane GO:0005367: myo-inositol:sodium symporter activity GO:0045356: positive regulation of interferon-alpha biosynthetic process GO:0071221: cellular response to bacterial lipopeptide GO:0008970: phospholipase A1 activity GO:0050897: cobalt ion binding GO:0007032: endosome organization GO:0035662: Toll-like receptor 4 binding GO:0071353: cellular response to interleukin-4 GO:0034145: positive regulation of toll-like receptor 4 signaling pathway GO:0007339: binding of sperm to zona pellucida GO:0045908: negative regulation of vasodilation GO:0051437: positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0072136: metanephric mesenchymal cell proliferation involved in metanephros development GO:0019532: oxalate transport GO:0045294: alpha-catenin binding GO:0009629: response to gravity GO:0051709: regulation of killing of cells of other organism GO:0006937: regulation of muscle contraction GO:0005290: L-histidine transmembrane transporter activity GO:0010983: positive regulation of high-density lipoprotein particle clearance GO:0009922: fatty acid elongase activity GO:0033602: negative regulation of dopamine secretion GO:0002866: positive regulation of acute inflammatory response to antigenic stimulus GO:0005605: basal lamina GO:0090041: negative regulation of gene-specific transcription elongation from RNA polymerase II promoter GO:0048808: male genitalia morphogenesis GO:0030223: neutrophil differentiation GO:0051295: establishment of meiotic spindle localization GO:0050661: NADP binding GO:0034617: tetrahydrobiopterin binding GO:0015099: nickel ion transmembrane transporter activity GO:0007418: ventral midline development GO:0010977: negative regulation of neuron projection development GO:0000050: urea cycle GO:0017034: Rap guanyl-nucleotide exchange factor activity GO:0022890: inorganic cation transmembrane transporter activity GO:0031526: brush border membrane GO:0019531: oxalate transmembrane transporter activity GO:0019290: siderophore biosynthetic process GO:0035250: UDP-galactosyltransferase activity GO:0048484: enteric nervous system development GO:0002028: regulation of sodium ion transport GO:0001530: lipopolysaccharide binding GO:0032696: negative regulation of interleukin-13 production GO:0016578: histone deubiquitination GO:0001609: adenosine receptor activity, G-protein coupled GO:0046086: adenosine biosynthetic process GO:0051436: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0090286: cytoskeletal anchoring at nuclear membrane GO:0051270: regulation of cellular component movement GO:0034230: enkephalin processing GO:2000065: negative regulation of cortisol biosynthetic process GO:0046931: pore complex assembly GO:0042761: very long-chain fatty acid biosynthetic process GO:0032900: negative regulation of neurotrophin production GO:0046653: tetrahydrofolate metabolic process GO:0016986: transcription initiation factor activity GO:0030183: B cell differentiation GO:0004517: nitric-oxide synthase activity GO:0006195: purine nucleotide catabolic process GO:0005871: kinesin complex GO:0003725: double-stranded RNA binding GO:0006829: zinc ion transport GO:0014741: negative regulation of muscle hypertrophy GO:0045060: negative thymic T cell selection GO:0050890: cognition GO:0048589: developmental growth GO:0035665: TIRAP-dependent toll-like receptor 4 signaling pathway GO:0014050: negative regulation of glutamate secretion GO:0019240: citrulline biosynthetic process GO:0071400: cellular response to oleic acid GO:0030502: negative regulation of bone mineralization GO:0002076: osteoblast development GO:0010043: response to zinc ion GO:0008095: inositol-1,4,5-trisphosphate receptor activity GO:0032279: asymmetric synapse GO:0033276: transcription factor TFTC complex GO:0015817: histidine transport GO:0072199: regulation of mesenchymal cell proliferation involved in ureter development GO:0015182: L-asparagine transmembrane transporter activity GO:0002087: regulation of respiratory gaseous exchange by neurological system process GO:0004513: neolactotetraosylceramide alpha-2,3-sialyltransferase activity GO:0031821: metabotropic serotonin receptor binding GO:0005218: intracellular ligand-gated calcium channel activity GO:0014054: positive regulation of gamma-aminobutyric acid secretion GO:0035338: long-chain fatty-acyl-CoA biosynthetic process GO:0032835: glomerulus development GO:0034405: response to fluid shear stress GO:0021513: spinal cord dorsal/ventral patterning GO:0030856: regulation of epithelial cell differentiation GO:0043271: negative regulation of ion transport GO:0045078: positive regulation of interferon-gamma biosynthetic process GO:0051290: protein heterotetramerization GO:0071899: negative regulation of estrogen receptor binding GO:0005131: growth hormone receptor binding GO:0071577: zinc ion transmembrane transport GO:2000063: positive regulation of ureter smooth muscle cell differentiation GO:2000358: positive regulation of kidney smooth muscle cell differentiation GO:0031527: filopodium membrane GO:0002227: innate immune response in mucosa GO:0006116: NADH oxidation GO:0048864: stem cell development GO:0050543: icosatetraenoic acid binding GO:0031685: adenosine receptor binding GO:0002320: lymphoid progenitor cell differentiation GO:0015094: lead ion transmembrane transporter activity GO:0060326: cell chemotaxis GO:0070627: ferrous iron import GO:0030574: collagen catabolic process GO:0042113: B cell activation GO:0004864: protein phosphatase inhibitor activity GO:0031117: positive regulation of microtubule depolymerization GO:0046923: ER retention sequence binding GO:0006513: protein monoubiquitination GO:0031088: platelet dense granule membrane GO:0045063: T-helper 1 cell differentiation GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0030010: establishment of cell polarity GO:0071436: sodium ion export GO:0003858: 3-hydroxybutyrate dehydrogenase activity GO:0042589: zymogen granule membrane GO:0044212: transcription regulatory region DNA binding GO:0043967: histone H4 acetylation GO:0034597: phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity GO:0016358: dendrite development GO:0034605: cellular response to heat GO:0051642: centrosome localization GO:0004095: carnitine O-palmitoyltransferase activity GO:0006612: protein targeting to membrane GO:0042307: positive regulation of protein import into nucleus GO:0060170: cilium membrane GO:0015808: L-alanine transport GO:0070542: response to fatty acid GO:0032059: bleb GO:0032403: protein complex binding GO:0015844: monoamine transport GO:0042100: B cell proliferation GO:0050805: negative regulation of synaptic transmission GO:0000293: ferric-chelate reductase activity GO:0016791: phosphatase activity GO:0005212: structural constituent of eye lens GO:0060058: positive regulation of apoptosis involved in mammary gland involution GO:0060685: regulation of prostatic bud formation GO:0048643: positive regulation of skeletal muscle tissue development GO:0032435: negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0030099: myeloid cell differentiation GO:0031581: hemidesmosome assembly GO:0016485: protein processing GO:0003831: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity GO:0008020: G-protein coupled photoreceptor activity GO:0055118: negative regulation of cardiac muscle contraction GO:0006406: mRNA export from nucleus GO:0008540: proteasome regulatory particle, base subcomplex GO:0002064: epithelial cell development GO:0046513: ceramide biosynthetic process GO:0002162: dystroglycan binding GO:0034231: islet amyloid polypeptide processing GO:0008093: cytoskeletal adaptor activity GO:0006621: protein retention in ER lumen GO:0015106: bicarbonate transmembrane transporter activity GO:0009584: detection of visible light GO:0047291: lactosylceramide alpha-2,3-sialyltransferase activity GO:0016998: cell wall macromolecule catabolic process GO:0034626: fatty acid elongation, polyunsaturated fatty acid GO:0032387: negative regulation of intracellular transport GO:0060447: bud outgrowth involved in lung branching GO:0060840: artery development GO:0060516: primary prostatic bud elongation GO:0042346: positive regulation of NF-kappaB import into nucleus GO:0046632: alpha-beta T cell differentiation GO:0001912: positive regulation of leukocyte mediated cytotoxicity GO:0046332: SMAD binding GO:0043615: astrocyte cell migration GO:0031100: organ regeneration GO:0033092: positive regulation of immature T cell proliferation in thymus GO:0042168: heme metabolic process GO:0001578: microtubule bundle formation GO:0000138: Golgi trans cisterna GO:2000340: positive regulation of chemokine (C-X-C motif) ligand 1 production GO:0014858: positive regulation of skeletal muscle cell proliferation GO:0030112: glycocalyx GO:0051895: negative regulation of focal adhesion assembly GO:0044344: cellular response to fibroblast growth factor stimulus GO:0048646: anatomical structure formation involved in morphogenesis GO:0007026: negative regulation of microtubule depolymerization GO:0007442: hindgut morphogenesis GO:0006470: protein dephosphorylation GO:0043401: steroid hormone mediated signaling pathway GO:0048632: negative regulation of skeletal muscle tissue growth GO:0016615: malate dehydrogenase activity GO:0045445: myoblast differentiation GO:0001948: glycoprotein binding GO:0034137: positive regulation of toll-like receptor 2 signaling pathway GO:0015684: ferrous iron transport GO:0006867: asparagine transport GO:0048821: erythrocyte development GO:0030070: insulin processing GO:0014706: striated muscle tissue development GO:0015301: anion:anion antiporter activity GO:0043268: positive regulation of potassium ion transport GO:0060459: left lung development GO:0050746: regulation of lipoprotein metabolic process GO:0021938: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0015086: cadmium ion transmembrane transporter activity GO:0004086: carbamoyl-phosphate synthase activity GO:0043279: response to alkaloid GO:0009597: detection of virus GO:0042308: negative regulation of protein import into nucleus GO:0007257: activation of JUN kinase activity GO:0006000: fructose metabolic process GO:0031464: Cul4A-RING ubiquitin ligase complex GO:0004629: phospholipase C activity GO:0010740: positive regulation of intracellular protein kinase cascade GO:0019834: phospholipase A2 inhibitor activity GO:0015081: sodium ion transmembrane transporter activity GO:0030878: thyroid gland development GO:0021904: dorsal/ventral neural tube patterning GO:0060769: positive regulation of epithelial cell proliferation involved in prostate gland development GO:0031465: Cul4B-RING ubiquitin ligase complex GO:0019395: fatty acid oxidation GO:0005314: high-affinity glutamate transmembrane transporter activity GO:0034435: cholesterol esterification GO:0019367: fatty acid elongation, saturated fatty acid GO:0043392: negative regulation of DNA binding GO:0043587: tongue morphogenesis GO:0008486: diphosphoinositol-polyphosphate diphosphatase activity GO:0015087: cobalt ion transmembrane transporter activity GO:0017144: drug metabolic process GO:0032244: positive regulation of nucleoside transport GO:0032795: heterotrimeric G-protein binding GO:0004402: histone acetyltransferase activity GO:0043029: T cell homeostasis GO:0003920: GMP reductase activity GO:0005876: spindle microtubule GO:0030914: STAGA complex GO:0015675: nickel ion transport GO:0006824: cobalt ion transport GO:0005932: microtubule basal body GO:0005385: zinc ion transmembrane transporter activity GO:0008328: ionotropic glutamate receptor complex GO:0006606: protein import into nucleus GO:0032735: positive regulation of interleukin-12 production GO:0032713: negative regulation of interleukin-4 production GO:0005272: sodium channel activity GO:0002052: positive regulation of neuroblast proliferation GO:0080125: multicellular structure septum development GO:0044254: multicellular organismal protein catabolic process GO:0032591: dendritic spine membrane GO:0048155: S100 alpha binding GO:0016705: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0030742: GTP-dependent protein binding GO:0008115: sarcosine oxidase activity GO:0015692: lead ion transport GO:0030217: T cell differentiation GO:0070779: D-aspartate import GO:0005542: folic acid binding GO:0050965: detection of temperature stimulus involved in sensory perception of pain GO:0070016: armadillo repeat domain binding GO:0055081: anion homeostasis GO:0042158: lipoprotein biosynthetic process GO:0048314: embryo sac morphogenesis GO:0005324: long-chain fatty acid transporter activity #1095IR 753 GO:0048676: axon extension involved in development GO:0032052: bile acid binding GO:0009790: embryonic development GO:0006807: nitrogen compound metabolic process GO:0007519: skeletal muscle development GO:0007212: dopamine receptor signaling pathway GO:0009434: microtubule-based flagellum GO:0010766: negative regulation of sodium ion transport GO:0005761: mitochondrial ribosome GO:0050665: hydrogen peroxide biosynthetic process GO:0004828: serine-tRNA ligase activity GO:0004017: adenylate kinase activity GO:0032781: positive regulation of ATPase activity GO:0004813: alanine-tRNA ligase activity GO:0043754: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity GO:0031105: septin complex GO:0006413: translational initiation GO:0019911: structural constituent of myelin sheath GO:0046933: hydrogen ion transporting ATP synthase activity, rotational mechanism GO:0004579: dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0042384: cilium assembly GO:0014068: positive regulation of phosphoinositide 3-kinase cascade GO:0045747: positive regulation of Notch signaling pathway GO:0019835: cytolysis GO:0043507: positive regulation of JUN kinase activity GO:0005885: Arp2/3 protein complex GO:0051603: proteolysis involved in cellular protein catabolic process GO:0009755: hormone-mediated signaling GO:0006857: oligopeptide transport GO:0051538: 3 iron, 4 sulfur cluster binding GO:0004825: methionine-tRNA ligase activity GO:0033179: proton-transporting V-type ATPase, V0 domain GO:0004347: glucose-6-phosphate isomerase activity GO:0043498: cell surface binding GO:0009086: methionine biosynthetic process GO:0003983: UTP:glucose-1-phosphate uridylyltransferase activity GO:0006694: steroid biosynthetic process GO:0008494: translation activator activity GO:0018193: peptidyl-amino acid modification GO:0047042: 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity GO:0031571: G1 DNA damage checkpoint GO:0003954: NADH dehydrogenase activity GO:0042511: positive regulation of tyrosine phosphorylation of Stat1 protein GO:0015520: tetracycline:hydrogen antiporter activity GO:0051346: negative regulation of hydrolase activity GO:0006959: humoral immune response GO:0004800: thyroxine 5'-deiodinase activity GO:0003980: UDP-glucose:glycoprotein glucosyltransferase activity GO:0006590: thyroid hormone generation GO:0045636: positive regulation of melanocyte differentiation GO:0001601: peptide YY receptor activity GO:0031669: cellular response to nutrient levels GO:0051016: barbed-end actin filament capping GO:0048269: methionine adenosyltransferase complex GO:0005151: interleukin-1, Type II receptor binding GO:0035091: phosphoinositide binding GO:0004337: geranyltranstransferase activity GO:0000224: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity GO:0004984: olfactory receptor activity GO:0046902: regulation of mitochondrial membrane permeability GO:0005762: mitochondrial large ribosomal subunit GO:0016229: steroid dehydrogenase activity GO:0050815: phosphoserine binding GO:0018879: biphenyl metabolic process GO:0007369: gastrulation GO:0019902: phosphatase binding GO:0045298: tubulin complex GO:0005000: vasopressin receptor activity GO:0017183: peptidyl-diphthamide biosynthetic process from peptidyl-histidine GO:0005839: proteasome core complex GO:0005763: mitochondrial small ribosomal subunit GO:0005859: muscle myosin complex GO:0006563: L-serine metabolic process GO:0015457: auxiliary transport protein activity GO:0015272: ATP-activated inward rectifier potassium channel activity GO:0005643: nuclear pore GO:0046934: phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0001945: lymph vessel development GO:0021954: central nervous system neuron development GO:0046961: proton-transporting ATPase activity, rotational mechanism GO:0032287: myelin maintenance in the peripheral nervous system GO:0008061: chitin binding GO:0008449: N-acetylglucosamine-6-sulfatase activity GO:0045815: positive regulation of gene expression, epigenetic GO:0052171: growth or development during symbiotic interaction GO:0015450: P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0021965: spinal cord ventral commissure morphogenesis GO:0016786: selenotransferase activity GO:0019008: molybdopterin synthase complex GO:0005840: ribosome GO:0006368: RNA elongation from RNA polymerase II promoter GO:0045475: locomotor rhythm GO:0004697: protein kinase C activity GO:0006519: cellular amino acid and derivative metabolic process GO:0045840: positive regulation of mitosis GO:0001895: retina homeostasis GO:0005942: phosphoinositide 3-kinase complex GO:0005744: mitochondrial inner membrane presequence translocase complex GO:0004905: type I interferon receptor activity GO:0006431: methionyl-tRNA aminoacylation GO:0051146: striated muscle cell differentiation GO:0002318: myeloid progenitor cell differentiation GO:0006027: glycosaminoglycan catabolic process GO:0048861: leukemia inhibitory factor signaling pathway GO:0004035: alkaline phosphatase activity GO:0035254: glutamate receptor binding GO:0004743: pyruvate kinase activity GO:0008479: queuine tRNA-ribosyltransferase activity GO:0004174: electron-transferring-flavoprotein dehydrogenase activity GO:0015904: tetracycline transport GO:0032729: positive regulation of interferon-gamma production GO:0016846: carbon-sulfur lyase activity GO:0003729: mRNA binding GO:0043209: myelin sheath GO:0005851: eukaryotic translation initiation factor 2B complex GO:0050661: NADP or NADPH binding GO:0000275: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) GO:0000119: mediator complex GO:0005746: mitochondrial respiratory chain GO:0004656: procollagen-proline 4-dioxygenase activity GO:0030515: snoRNA binding GO:0042423: catecholamine biosynthetic process GO:0001817: regulation of cytokine production GO:0032038: myosin II heavy chain binding GO:0004771: sterol esterase activity GO:0015248: sterol transporter activity GO:0004569: glycoprotein endo-alpha-1,2-mannosidase activity GO:0006414: translational elongation GO:0030071: regulation of mitotic metaphase/anaphase transition GO:0008616: queuosine biosynthetic process GO:0006817: phosphate transport GO:0005139: interleukin-7 receptor binding GO:0051450: myoblast proliferation GO:0000247: C-8 sterol isomerase activity GO:0006122: mitochondrial electron transport, ubiquinol to cytochrome c GO:0030060: L-malate dehydrogenase activity GO:0033119: negative regulation of RNA splicing GO:0009303: rRNA transcription GO:0045648: positive regulation of erythrocyte differentiation GO:0008177: succinate dehydrogenase (ubiquinone) activity GO:0004134: 4-alpha-glucanotransferase activity GO:0045899: positive regulation of transcriptional preinitiation complex assembly GO:0019206: nucleoside kinase activity GO:0045843: negative regulation of striated muscle development GO:0000254: C-4 methylsterol oxidase activity GO:0004504: peptidylglycine monooxygenase activity GO:0051287: NAD or NADH binding GO:0050840: extracellular matrix binding GO:0042491: auditory receptor cell differentiation GO:0008353: RNA polymerase subunit kinase activity GO:0005173: stem cell factor receptor binding GO:0006904: vesicle docking during exocytosis GO:0004587: ornithine-oxo-acid transaminase activity GO:0034464: BBSome GO:0044237: cellular metabolic process GO:0004897: ciliary neurotrophic factor receptor activity GO:0032801: receptor catabolic process GO:0006298: mismatch repair GO:0042255: ribosome assembly GO:0042273: ribosomal large subunit biogenesis GO:0006544: glycine metabolic process GO:0045446: endothelial cell differentiation GO:0008190: eukaryotic initiation factor 4E binding GO:0004165: dodecenoyl-CoA delta-isomerase activity GO:0003906: DNA-(apurinic or apyrimidinic site) lyase activity GO:0004008: copper-exporting ATPase activity GO:0045261: proton-transporting ATP synthase complex, catalytic core F(1) GO:0002262: myeloid cell homeostasis GO:0004487: methylenetetrahydrofolate dehydrogenase (NAD+) activity GO:0045794: negative regulation of cell volume GO:0018279: protein amino acid N-linked glycosylation via asparagine GO:0006338: chromatin remodeling GO:0060163: subpallium neuron fate commitment GO:0046677: response to antibiotic GO:0043353: enucleate erythrocyte differentiation GO:0003684: damaged DNA binding GO:0051208: sequestering of calcium ion GO:0051087: chaperone binding GO:0003887: DNA-directed DNA polymerase activity GO:0043218: compact myelin GO:0043033: isoamylase complex GO:0045947: negative regulation of translational initiation GO:0000387: spliceosomal snRNP biogenesis GO:0047021: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity GO:0005126: hematopoietin/interferon-class (D200-domain) cytokine receptor binding GO:0008299: isoprenoid biosynthetic process GO:0045239: tricarboxylic acid cycle enzyme complex GO:0020027: hemoglobin metabolic process GO:0030534: adult behavior GO:0002687: positive regulation of leukocyte migration GO:0042921: glucocorticoid receptor signaling pathway GO:0016251: general RNA polymerase II transcription factor activity GO:0008137: NADH dehydrogenase (ubiquinone) activity GO:0000380: alternative nuclear mRNA splicing, via spliceosome GO:0003705: RNA polymerase II transcription factor activity, enhancer binding GO:0065002: intracellular protein transmembrane transport GO:0003706: ligand-regulated transcription factor activity GO:0019789: SUMO ligase activity GO:0019682: glyceraldehyde-3-phosphate metabolic process GO:0004521: endoribonuclease activity GO:0046854: phosphoinositide phosphorylation GO:0004921: interleukin-11 receptor activity GO:0016531: copper chaperone activity GO:0031403: lithium ion binding GO:0006924: activation-induced cell death of T cells GO:0047750: cholestenol delta-isomerase activity GO:0019209: kinase activator activity GO:0022625: cytosolic large ribosomal subunit GO:0032364: oxygen homeostasis GO:0046326: positive regulation of glucose import GO:0060052: neurofilament cytoskeleton organization GO:0043249: erythrocyte maturation GO:0004135: amylo-alpha-1,6-glucosidase activity GO:0008599: protein phosphatase type 1 regulator activity GO:0042552: myelination GO:0001932: regulation of protein amino acid phosphorylation GO:0016878: acid-thiol ligase activity GO:0055010: ventricular cardiac muscle morphogenesis GO:0002821: positive regulation of adaptive immune response GO:0060072: large conductance calcium-activated potassium channel activity GO:0005669: transcription factor TFIID complex GO:0001892: embryonic placenta development GO:0015721: bile acid and bile salt transport GO:0005784: translocon complex GO:0042759: long-chain fatty acid biosynthetic process GO:0001952: regulation of cell-matrix adhesion GO:0051920: peroxiredoxin activity GO:0006800: oxygen and reactive oxygen species metabolic process GO:0050221: prostaglandin-E2 9-reductase activity GO:0004526: ribonuclease P activity GO:0042769: DNA damage response, detection of DNA damage GO:0043039: tRNA aminoacylation GO:0030169: low-density lipoprotein binding GO:0007213: muscarinic acetylcholine receptor signaling pathway GO:0030371: translation repressor activity GO:0042541: hemoglobin biosynthetic process GO:0016081: synaptic vesicle docking during exocytosis GO:0004300: enoyl-CoA hydratase activity GO:0051318: G1 phase GO:0004634: phosphopyruvate hydratase activity GO:0004576: oligosaccharyl transferase activity GO:0006228: UTP biosynthetic process GO:0004161: dimethylallyltranstransferase activity GO:0006301: postreplication repair GO:0005977: glycogen metabolic process GO:0003923: GPI-anchor transamidase activity GO:0042719: mitochondrial intermembrane space protein transporter complex GO:0005853: eukaryotic translation elongation factor 1 complex GO:0006654: phosphatidic acid biosynthetic process GO:0033081: regulation of T cell differentiation in the thymus GO:0004064: arylesterase activity GO:0070330: aromatase activity GO:0042835: BRE binding GO:0000827: inositol 1,3,4,5,6-pentakisphosphate kinase activity GO:0008324: cation transmembrane transporter activity GO:0004065: arylsulfatase activity GO:0006221: pyrimidine nucleotide biosynthetic process GO:0060088: auditory receptor cell stereocilium organization GO:0008333: endosome to lysosome transport GO:0006082: organic acid metabolic process GO:0007309: oocyte axis specification GO:0004769: steroid delta-isomerase activity GO:0043025: cell soma GO:0006984: ER-nuclear signaling pathway GO:0031401: positive regulation of protein modification process GO:0007093: mitotic cell cycle checkpoint GO:0006309: DNA fragmentation during apoptosis GO:0004924: oncostatin-M receptor activity GO:0004550: nucleoside diphosphate kinase activity GO:0004740: pyruvate dehydrogenase (acetyl-transferring) kinase activity GO:0043162: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0004058: aromatic-L-amino-acid decarboxylase activity GO:0000381: regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000015: phosphopyruvate hydratase complex GO:0003988: acetyl-CoA C-acyltransferase activity GO:0016254: preassembly of GPI anchor in ER membrane GO:0000389: nuclear mRNA 3'-splice site recognition GO:0032259: methylation GO:0004159: dihydrouracil dehydrogenase (NAD+) activity GO:0045738: negative regulation of DNA repair GO:0051262: protein tetramerization GO:0000210: NAD+ diphosphatase activity GO:0000781: chromosome, telomeric region GO:0006518: peptide metabolic process GO:0004137: deoxycytidine kinase activity GO:0006011: UDP-glucose metabolic process GO:0033814: propanoyl-CoA C-acyltransferase activity GO:0005072: transforming growth factor beta receptor, cytoplasmic mediator activity GO:0006789: bilirubin conjugation GO:0006529: asparagine biosynthetic process GO:0031508: centromeric heterochromatin formation GO:0031119: tRNA pseudouridine synthesis GO:0031032: actomyosin structure organization GO:0008121: ubiquinol-cytochrome-c reductase activity GO:0043198: dendritic shaft GO:0001844: protein insertion into mitochondrial membrane during induction of apoptosis GO:0006777: Mo-molybdopterin cofactor biosynthetic process GO:0010768: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0030141: secretory granule GO:0000105: histidine biosynthetic process GO:0006120: mitochondrial electron transport, NADH to ubiquinone GO:0031014: troponin T binding GO:0005732: small nucleolar ribonucleoprotein complex GO:0019226: transmission of nerve impulse GO:0005086: ARF guanyl-nucleotide exchange factor activity GO:0019089: transmission of virus GO:0032236: positive regulation of calcium ion transport via store-operated calcium channel activity GO:0000090: mitotic anaphase GO:0004096: catalase activity GO:0004470: malic enzyme activity GO:0051541: elastin metabolic process GO:0046685: response to arsenic GO:0045926: negative regulation of growth GO:0006467: protein thiol-disulfide exchange GO:0060083: smooth muscle contraction involved in micturition GO:0004691: cAMP-dependent protein kinase activity GO:0010613: positive regulation of cardiac muscle hypertrophy GO:0016219: GDP-dissociation stimulator activity GO:0004715: non-membrane spanning protein tyrosine kinase activity GO:0042809: vitamin D receptor binding GO:0055009: atrial cardiac muscle morphogenesis GO:0032790: ribosome disassembly GO:0015917: aminophospholipid transport GO:0008633: activation of pro-apoptotic gene products GO:0019276: UDP-N-acetylgalactosamine metabolic process GO:0043550: regulation of lipid kinase activity GO:0032862: activation of Rho GTPase activity GO:0000900: translation repressor activity, nucleic acid binding GO:0008180: signalosome GO:0070063: RNA polymerase binding GO:0003746: translation elongation factor activity GO:0001514: selenocysteine incorporation GO:0033014: tetrapyrrole biosynthetic process GO:0015321: sodium-dependent phosphate transmembrane transporter activity GO:0006493: protein amino acid O-linked glycosylation GO:0050847: progesterone receptor signaling pathway GO:0031674: I band GO:0016018: cyclosporin A binding GO:0004784: superoxide dismutase activity GO:0019059: initiation of viral infection GO:0008536: Ran GTPase binding GO:0010458: exit from mitosis GO:0005112: Notch binding GO:0008641: small protein activating enzyme activity GO:0007051: spindle organization GO:0046755: non-lytic virus budding GO:0006710: androgen catabolic process GO:0000049: tRNA binding GO:0005850: eukaryotic translation initiation factor 2 complex GO:0005138: interleukin-6 receptor binding GO:0050819: negative regulation of coagulation GO:0004590: orotidine-5'-phosphate decarboxylase activity GO:0017076: purine nucleotide binding GO:0006418: tRNA aminoacylation for protein translation GO:0002675: positive regulation of acute inflammatory response GO:0009249: protein lipoylation GO:0030203: glycosaminoglycan metabolic process GO:0060166: olfactory pit development GO:0004598: peptidylamidoglycolate lyase activity GO:0004647: phosphoserine phosphatase activity GO:0007220: Notch receptor processing GO:0047115: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity GO:0015991: ATP hydrolysis coupled proton transport GO:0045453: bone resorption GO:0006520: amino acid metabolic process GO:0006471: protein amino acid ADP-ribosylation GO:0033857: diphosphoinositol-pentakisphosphate kinase activity GO:0048806: genitalia development GO:0004915: interleukin-6 receptor activity GO:0006106: fumarate metabolic process GO:0004861: cyclin-dependent protein kinase inhibitor activity GO:0051877: pigment granule aggregation in cell center GO:0046716: muscle maintenance GO:0004563: beta-N-acetylhexosaminidase activity GO:0045494: photoreceptor cell maintenance GO:0000178: exosome (RNase complex) GO:0045931: positive regulation of mitotic cell cycle GO:0047804: cysteine-S-conjugate beta-lyase activity GO:0001934: positive regulation of protein amino acid phosphorylation GO:0006434: seryl-tRNA aminoacylation GO:0019871: sodium channel inhibitor activity GO:0047006: 20-alpha-hydroxysteroid dehydrogenase activity GO:0000832: inositol hexakisphosphate 5-kinase activity GO:0019752: carboxylic acid metabolic process GO:0000077: DNA damage checkpoint GO:0005498: sterol carrier activity GO:0045116: protein neddylation GO:0016407: acetyltransferase activity GO:0008831: dTDP-4-dehydrorhamnose reductase activity GO:0006183: GTP biosynthetic process GO:0009982: pseudouridine synthase activity GO:0001757: somite specification GO:0033989: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity GO:0003735: structural constituent of ribosome GO:0019787: small conjugating protein ligase activity GO:0000027: ribosomal large subunit assembly GO:0006110: regulation of glycolysis GO:0009165: nucleotide biosynthetic process GO:0015934: large ribosomal subunit GO:0033044: regulation of chromosome organization GO:0001888: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0043024: ribosomal small subunit binding GO:0051716: cellular response to stimulus GO:0032020: ISG15-protein conjugation GO:0004333: fumarate hydratase activity GO:0006730: one-carbon compound metabolic process GO:0004556: alpha-amylase activity GO:0006778: porphyrin metabolic process GO:0017119: Golgi transport complex GO:0004190: aspartic-type endopeptidase activity GO:0046886: positive regulation of hormone biosynthetic process GO:0051017: actin filament bundle formation GO:0003874: 6-pyruvoyltetrahydropterin synthase activity GO:0004981: muscarinic acetylcholine receptor activity GO:0031118: rRNA pseudouridine synthesis GO:0006689: ganglioside catabolic process GO:0034263: autophagy in response to ER overload GO:0055007: cardiac muscle cell differentiation GO:0003743: translation initiation factor activity GO:0031698: beta-2 adrenergic receptor binding GO:0008441: 3'(2'),5'-bisphosphate nucleotidase activity GO:0008652: amino acid biosynthetic process GO:0031575: G1/S transition checkpoint GO:0031362: anchored to external side of plasma membrane GO:0000279: M phase GO:0042780: tRNA 3'-end processing GO:0051000: positive regulation of nitric-oxide synthase activity GO:0004843: ubiquitin-specific protease activity GO:0016773: phosphotransferase activity, alcohol group as acceptor GO:0006583: melanin biosynthetic process from tyrosine GO:0005678: chromatin assembly complex GO:0006970: response to osmotic stress GO:0043666: regulation of phosphoprotein phosphatase activity GO:0042787: protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0008389: coumarin 7-hydroxylase activity GO:0004105: choline-phosphate cytidylyltransferase activity GO:0030833: regulation of actin filament polymerization GO:0043015: gamma-tubulin binding GO:0043560: insulin receptor substrate binding GO:0005751: mitochondrial respiratory chain complex IV GO:0004581: dolichyl-phosphate beta-glucosyltransferase activity GO:0008250: oligosaccharyltransferase complex GO:0000276: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) GO:0032473: external side of mitochondrial outer membrane GO:0051246: regulation of protein metabolic process GO:0048547: gut morphogenesis GO:0005010: insulin-like growth factor receptor activity GO:0015020: glucuronosyltransferase activity GO:0004132: dCMP deaminase activity GO:0032344: regulation of aldosterone metabolic process GO:0043297: apical junction assembly GO:0007184: SMAD protein nuclear translocation GO:0005534: galactose binding GO:0045039: protein import into mitochondrial inner membrane GO:0005153: interleukin-8 receptor binding GO:0016255: attachment of GPI anchor to protein GO:0004969: histamine receptor activity GO:0000307: cyclin-dependent protein kinase holoenzyme complex GO:0042171: lysophosphatidic acid acyltransferase activity GO:0007163: establishment or maintenance of cell polarity GO:0004485: methylcrotonoyl-CoA carboxylase activity GO:0033180: proton-transporting V-type ATPase, V1 domain GO:0016494: C-X-C chemokine receptor activity GO:0006928: cell motion GO:0004970: ionotropic glutamate receptor activity GO:0015446: arsenite transmembrane-transporting ATPase activity GO:0002009: morphogenesis of an epithelium GO:0004948: calcitonin receptor activity GO:0033269: internode region of axon GO:0019843: rRNA binding GO:0009841: mitochondrial endopeptidase Clp complex GO:0005246: calcium channel regulator activity GO:0005686: snRNP U2 GO:0042765: GPI-anchor transamidase complex GO:0008634: negative regulation of survival gene product expression GO:0035248: alpha-1,4-N-acetylgalactosaminyltransferase activity GO:0005068: transmembrane receptor protein tyrosine kinase adaptor protein activity GO:0007569: cell aging GO:0046839: phospholipid dephosphorylation GO:0008157: protein phosphatase 1 binding GO:0005753: mitochondrial proton-transporting ATP synthase complex GO:0042771: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0000792: heterochromatin GO:0017101: aminoacyl-tRNA synthetase multienzyme complex GO:0030586: [methionine synthase] reductase activity GO:0045837: negative regulation of membrane potential GO:0001573: ganglioside metabolic process GO:0051028: mRNA transport GO:0005579: membrane attack complex GO:0006626: protein targeting to mitochondrion GO:0008206: bile acid metabolic process GO:0004865: protein serine/threonine phosphatase inhibitor activity GO:0000398: nuclear mRNA splicing, via spliceosome GO:0021537: telencephalon development GO:0008049: male courtship behavior GO:0060081: membrane hyperpolarization GO:0006556: S-adenosylmethionine biosynthetic process GO:0015319: sodium:inorganic phosphate symporter activity GO:0006744: ubiquinone biosynthetic process GO:0021554: optic nerve development GO:0006400: tRNA modification GO:0032767: copper-dependent protein binding GO:0032467: positive regulation of cytokinesis GO:0051536: iron-sulfur cluster binding GO:0000386: second spliceosomal transesterification activity GO:0006790: sulfur metabolic process GO:0048675: axon extension GO:0006104: succinyl-CoA metabolic process GO:0008089: anterograde axon cargo transport GO:0000070: mitotic sister chromatid segregation GO:0012506: vesicle membrane GO:0019885: antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0042587: glycogen granule GO:0003823: antigen binding GO:0035267: NuA4 histone acetyltransferase complex GO:0007158: neuron adhesion GO:0030299: cholesterol absorption GO:0004012: phospholipid-translocating ATPase activity GO:0007281: germ cell development GO:0042296: ISG15 ligase activity GO:0048270: methionine adenosyltransferase regulator activity GO:0007400: neuroblast fate determination GO:0051881: regulation of mitochondrial membrane potential GO:0030001: metal ion transport GO:0002763: positive regulation of myeloid leukocyte differentiation GO:0000272: polysaccharide catabolic process GO:0050816: phosphothreonine binding GO:0009060: aerobic respiration GO:0007157: heterophilic cell adhesion GO:0006552: leucine catabolic process GO:0005487: nucleocytoplasmic transporter activity GO:0045668: negative regulation of osteoblast differentiation GO:0045010: actin nucleation GO:0042776: mitochondrial ATP synthesis coupled proton transport GO:0004477: methenyltetrahydrofolate cyclohydrolase activity GO:0051823: regulation of synapse structural plasticity GO:0060165: regulation of timing of subpallium neuron differentiation GO:0005900: oncostatin-M receptor complex GO:0045651: positive regulation of macrophage differentiation GO:0042221: response to chemical stimulus GO:0006360: transcription from RNA polymerase I promoter GO:0021779: oligodendrocyte cell fate commitment GO:0035173: histone kinase activity GO:0004066: asparagine synthase (glutamine-hydrolyzing) activity GO:0001516: prostaglandin biosynthetic process GO:0009396: folic acid and derivative biosynthetic process GO:0004311: farnesyltranstransferase activity GO:0032446: protein modification by small protein conjugation GO:0016272: prefoldin complex GO:0006020: inositol metabolic process GO:0003755: peptidyl-prolyl cis-trans isomerase activity GO:0043183: vascular endothelial growth factor receptor 1 binding GO:0018106: peptidyl-histidine phosphorylation GO:0005672: transcription factor TFIIA complex GO:0045226: extracellular polysaccharide biosynthetic process GO:0006401: RNA catabolic process GO:0006098: pentose-phosphate shunt GO:0045095: keratin filament GO:0004372: glycine hydroxymethyltransferase activity GO:0008033: tRNA processing GO:0000184: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0007193: inhibition of adenylate cyclase activity by G-protein signaling GO:0005680: anaphase-promoting complex GO:0016706: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0005663: DNA replication factor C complex GO:0048147: negative regulation of fibroblast proliferation GO:0033178: proton-transporting two-sector ATPase complex, catalytic domain GO:0031323: regulation of cellular metabolic process GO:0030628: pre-mRNA 3'-splice site binding GO:0005947: mitochondrial alpha-ketoglutarate dehydrogenase complex GO:0045930: negative regulation of mitotic cell cycle GO:0008235: metalloexopeptidase activity GO:0008047: enzyme activator activity GO:0046966: thyroid hormone receptor binding GO:0000120: RNA polymerase I transcription factor complex GO:0006611: protein export from nucleus GO:0004830: tryptophan-tRNA ligase activity GO:0005674: transcription factor TFIIF complex GO:0005655: nucleolar ribonuclease P complex GO:0050790: regulation of catalytic activity GO:0004129: cytochrome-c oxidase activity GO:0004331: fructose-2,6-bisphosphate 2-phosphatase activity GO:0006265: DNA topological change GO:0060082: eye blink reflex GO:0030218: erythrocyte differentiation GO:0051437: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0001919: regulation of receptor recycling GO:0032391: photoreceptor connecting cilium GO:0035110: leg morphogenesis GO:0001669: acrosome GO:0016458: gene silencing GO:0030433: ER-associated protein catabolic process GO:0046541: saliva secretion GO:0004810: tRNA adenylyltransferase activity GO:0051436: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0004060: arylamine N-acetyltransferase activity GO:0032402: melanosome transport GO:0003918: DNA topoisomerase (ATP-hydrolyzing) activity GO:0000038: very-long-chain fatty acid metabolic process GO:0060047: heart contraction GO:0009405: pathogenesis GO:0048341: paraxial mesoderm formation GO:0044445: cytosolic part GO:0006089: lactate metabolic process GO:0004588: orotate phosphoribosyltransferase activity GO:0003870: 5-aminolevulinate synthase activity GO:0004090: carbonyl reductase (NADPH) activity GO:0032027: myosin light chain binding GO:0015270: dihydropyridine-sensitive calcium channel activity GO:0002248: connective tissue replacement during inflammatory response GO:0048496: maintenance of organ identity GO:0007206: activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway GO:0050220: prostaglandin-E synthase activity GO:0015986: ATP synthesis coupled proton transport GO:0006878: cellular copper ion homeostasis GO:0003844: 1,4-alpha-glucan branching enzyme activity GO:0005681: spliceosome GO:0045582: positive regulation of T cell differentiation GO:0016805: dipeptidase activity GO:0015105: arsenite transmembrane transporter activity GO:0004597: peptide-aspartate beta-dioxygenase activity GO:0004063: aryldialkylphosphatase activity GO:0016769: transferase activity, transferring nitrogenous groups GO:0050658: RNA transport GO:0042554: superoxide release GO:0008593: regulation of Notch signaling pathway GO:0010259: multicellular organismal aging GO:0005861: troponin complex GO:0046034: ATP metabolic process GO:0018738: S-formylglutathione hydrolase activity GO:0004923: leukemia inhibitory factor receptor activity GO:0000245: spliceosome assembly GO:0004823: leucine-tRNA ligase activity GO:0006241: CTP biosynthetic process GO:0021542: dentate gyrus development GO:0042826: histone deacetylase binding GO:0009416: response to light stimulus GO:0004033: aldo-keto reductase activity GO:0046824: positive regulation of nucleocytoplasmic transport GO:0000059: protein import into nucleus, docking GO:0006474: N-terminal protein amino acid acetylation GO:0008080: N-acetyltransferase activity GO:0004423: iduronate-2-sulfatase activity GO:0032012: regulation of ARF protein signal transduction GO:0042137: sequestering of neurotransmitter GO:0001786: phosphatidylserine binding GO:0005896: interleukin-6 receptor complex GO:0001891: phagocytic cup GO:0002026: regulation of the force of heart contraction GO:0051044: positive regulation of membrane protein ectodomain proteolysis GO:0015677: copper ion import GO:0045509: interleukin-27 receptor activity GO:0006275: regulation of DNA replication GO:0009399: nitrogen fixation GO:0004303: estradiol 17-beta-dehydrogenase activity GO:0051059: NF-kappaB binding GO:0006687: glycosphingolipid metabolic process GO:0004618: phosphoglycerate kinase activity GO:0040016: embryonic cleavage GO:0007127: meiosis I GO:0033981: D-dopachrome decarboxylase activity GO:0045541: negative regulation of cholesterol biosynthetic process GO:0004298: threonine-type endopeptidase activity GO:0005031: tumor necrosis factor receptor activity GO:0045444: fat cell differentiation GO:0032088: negative regulation of NF-kappaB transcription factor activity GO:0022627: cytosolic small ribosomal subunit GO:0006449: regulation of translational termination GO:0046619: optic placode formation involved in camera-type eye GO:0006610: ribosomal protein import into nucleus GO:0003689: DNA clamp loader activity GO:0045263: proton-transporting ATP synthase complex, coupling factor F(o) GO:0004807: triose-phosphate isomerase activity GO:0004831: tyrosine-tRNA ligase activity GO:0006200: ATP catabolic process GO:0016998: cell wall catabolic process GO:0006729: tetrahydrobiopterin biosynthetic process GO:0000153: cytoplasmic ubiquitin ligase complex GO:0007608: sensory perception of smell GO:0006429: leucyl-tRNA aminoacylation GO:0046579: positive regulation of Ras protein signal transduction GO:0021530: spinal cord oligodendrocyte cell fate specification GO:0006622: protein targeting to lysosome GO:0043619: regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0016212: kynurenine-oxoglutarate transaminase activity GO:0016149: translation release factor activity, codon specific GO:0003720: telomerase activity GO:0034465: response to carbon monoxide GO:0007243: protein kinase cascade GO:0005673: transcription factor TFIIE complex GO:0015238: drug transporter activity GO:0006436: tryptophanyl-tRNA aminoacylation GO:0000175: 3'-5'-exoribonuclease activity GO:0015074: DNA integration GO:0030007: cellular potassium ion homeostasis GO:0031307: integral to mitochondrial outer membrane GO:0031672: A band GO:0001819: positive regulation of cytokine production GO:0006446: regulation of translational initiation GO:0016198: axon choice point recognition GO:0010001: glial cell differentiation GO:0031175: neurite development GO:0003995: acyl-CoA dehydrogenase activity GO:0008038: neuron recognition GO:0004003: ATP-dependent DNA helicase activity GO:0042446: hormone biosynthetic process GO:0019829: cation-transporting ATPase activity GO:0046949: acyl-CoA biosynthetic process GO:0003701: RNA polymerase I transcription factor activity GO:0030529: ribonucleoprotein complex GO:0016226: iron-sulfur cluster assembly GO:0022010: myelination in the central nervous system GO:0004776: succinate-CoA ligase (GDP-forming) activity GO:0031252: cell leading edge GO:0004428: inositol or phosphatidylinositol kinase activity GO:0007292: female gamete generation GO:0004998: transferrin receptor activity GO:0030041: actin filament polymerization GO:0006437: tyrosyl-tRNA aminoacylation GO:0004164: diphthine synthase activity GO:0003678: DNA helicase activity GO:0005747: mitochondrial respiratory chain complex I GO:0004167: dopachrome isomerase activity GO:0006325: establishment or maintenance of chromatin architecture GO:0016303: 1-phosphatidylinositol-3-kinase activity GO:0016281: eukaryotic translation initiation factor 4F complex GO:0016810: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0030240: muscle thin filament assembly GO:0031202: RNA splicing factor activity, transesterification mechanism GO:0043022: ribosome binding GO:0045821: positive regulation of glycolysis GO:0006364: rRNA processing GO:0048102: autophagic cell death GO:0006487: protein amino acid N-linked glycosylation GO:0034235: GPI anchor binding GO:0030983: mismatched DNA binding GO:0007017: microtubule-based process GO:0048015: phosphoinositide-mediated signaling GO:0045730: respiratory burst GO:0019538: protein metabolic process GO:0042404: thyroid hormone catabolic process GO:0019048: virus-host interaction GO:0009628: response to abiotic stimulus GO:0042149: cellular response to glucose starvation GO:0031405: lipoic acid binding GO:0003883: CTP synthase activity GO:0042623: ATPase activity, coupled GO:0005697: telomerase holoenzyme complex GO:0003857: 3-hydroxyacyl-CoA dehydrogenase activity GO:0050576: 3-keto-steroid reductase activity GO:0016818: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0021527: spinal cord association neuron differentiation GO:0006419: alanyl-tRNA aminoacylation #1043IR 4 GO:0032060: bleb formation GO:0035025: positive regulation of Rho protein signal transduction GO:0016188: synaptic vesicle maturation GO:0001619: lysosphingolipid and lysophosphatidic acid receptor activity #1051IR 39 GO:0006891: intra-Golgi vesicle-mediated transport GO:0045104: intermediate filament cytoskeleton organization GO:0005523: tropomyosin binding GO:0002891: positive regulation of immunoglobulin mediated immune response GO:0014731: spectrin-associated cytoskeleton GO:0006893: Golgi to plasma membrane transport GO:0031256: leading edge membrane GO:0005499: vitamin D binding GO:0015327: cystine:glutamate antiporter activity GO:0045055: regulated secretory pathway GO:0030507: spectrin binding GO:0042462: eye photoreceptor cell development GO:0030239: myofibril assembly GO:0004435: phosphoinositide phospholipase C activity GO:0005496: steroid binding GO:0000156: two-component response regulator activity GO:0008091: spectrin GO:0060084: synaptic transmission involved in micturition GO:0010839: negative regulation of keratinocyte proliferation GO:0030016: myofibril GO:0007352: zygotic determination of dorsal/ventral axis GO:0019215: intermediate filament binding GO:0030259: lipid glycosylation GO:0033005: positive regulation of mast cell activation GO:0016180: snRNA processing GO:0005577: fibrinogen complex GO:0016235: aggresome GO:0032039: integrator complex GO:0035095: behavioral response to nicotine GO:0006198: cAMP catabolic process GO:0030140: trans-Golgi network transport vesicle GO:0005024: transforming growth factor beta receptor activity GO:0000160: two-component signal transduction system (phosphorelay) GO:0060053: neurofilament cytoskeleton GO:0060369: positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0046488: phosphatidylinositol metabolic process GO:0048812: neurite morphogenesis GO:0048041: focal adhesion formation GO:0002860: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target #1063IR 719 GO:0009100: glycoprotein metabolic process GO:0034446: substrate adhesion-dependent cell spreading GO:0001921: positive regulation of receptor recycling GO:0043067: regulation of programmed cell death GO:0051707: response to other organism GO:0008652: cellular amino acid biosynthetic process GO:0001702: gastrulation with mouth forming second GO:0070244: negative regulation of thymocyte apoptosis GO:0007631: feeding behavior GO:0002001: renin secretion into blood stream GO:0046111: xanthine biosynthetic process GO:0019229: regulation of vasoconstriction GO:0043259: laminin-10 complex GO:0044430: cytoskeletal part GO:0000724: double-strand break repair via homologous recombination GO:0035385: Roundabout signaling pathway GO:0008589: regulation of smoothened signaling pathway GO:0005451: monovalent cation:hydrogen antiporter activity GO:0019863: IgE binding GO:0019067: viral assembly, maturation, egress, and release GO:0042581: specific granule GO:0009267: cellular response to starvation GO:0030169: low-density lipoprotein particle binding GO:0001932: regulation of protein phosphorylation GO:0060347: heart trabecula formation GO:0009258: 10-formyltetrahydrofolate catabolic process GO:0090024: negative regulation of neutrophil chemotaxis GO:0060512: prostate gland morphogenesis GO:0042588: zymogen granule GO:0006270: DNA-dependent DNA replication initiation GO:0060421: positive regulation of heart growth GO:0007129: synapsis GO:0007249: I-kappaB kinase/NF-kappaB cascade GO:0015879: carnitine transport GO:0007263: nitric oxide mediated signal transduction GO:0043518: negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0034188: apolipoprotein A-I receptor activity GO:0034371: chylomicron remodeling GO:0009743: response to carbohydrate stimulus GO:0042405: nuclear inclusion body GO:0031663: lipopolysaccharide-mediated signaling pathway GO:0006379: mRNA cleavage GO:0016064: immunoglobulin mediated immune response GO:0035329: hippo signaling cascade GO:0002314: germinal center B cell differentiation GO:0001946: lymphangiogenesis GO:0071333: cellular response to glucose stimulus GO:0090103: cochlea morphogenesis GO:0045071: negative regulation of viral genome replication GO:0032494: response to peptidoglycan GO:0050772: positive regulation of axonogenesis GO:0019894: kinesin binding GO:0000123: histone acetyltransferase complex GO:0021510: spinal cord development GO:0035602: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow GO:0051930: regulation of sensory perception of pain GO:0046950: cellular ketone body metabolic process GO:0015174: basic amino acid transmembrane transporter activity GO:0002790: peptide secretion GO:0022008: neurogenesis GO:0000299: integral to membrane of membrane fraction GO:0050925: negative regulation of negative chemotaxis GO:0060527: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0030837: negative regulation of actin filament polymerization GO:0030676: Rac guanyl-nucleotide exchange factor activity GO:0040017: positive regulation of locomotion GO:0071385: cellular response to glucocorticoid stimulus GO:0035024: negative regulation of Rho protein signal transduction GO:0060412: ventricular septum morphogenesis GO:0016594: glycine binding GO:0050999: regulation of nitric-oxide synthase activity GO:0070141: response to UV-A GO:0009888: tissue development GO:0042730: fibrinolysis GO:0046696: lipopolysaccharide receptor complex GO:0060169: negative regulation of adenosine receptor signaling pathway GO:0007501: mesodermal cell fate specification GO:0035235: ionotropic glutamate receptor signaling pathway GO:0043046: DNA methylation involved in gamete generation GO:0008331: high voltage-gated calcium channel activity GO:0006497: protein lipidation GO:0043129: surfactant homeostasis GO:0021769: orbitofrontal cortex development GO:0046697: decidualization GO:0004123: cystathionine gamma-lyase activity GO:0015038: glutathione disulfide oxidoreductase activity GO:0042165: neurotransmitter binding GO:0048562: embryonic organ morphogenesis GO:0000062: fatty-acyl-CoA binding GO:0034752: cytosolic aryl hydrocarbon receptor complex GO:0033280: response to vitamin D GO:0045130: keratan sulfotransferase activity GO:0050727: regulation of inflammatory response GO:0004117: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity GO:0051168: nuclear export GO:0060501: positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0051225: spindle assembly GO:0060688: regulation of morphogenesis of a branching structure GO:0033691: sialic acid binding GO:0045103: intermediate filament-based process GO:0005283: sodium:amino acid symporter activity GO:0060024: rhythmic synaptic transmission GO:0034361: very-low-density lipoprotein particle GO:0070189: kynurenine metabolic process GO:0001954: positive regulation of cell-matrix adhesion GO:0001505: regulation of neurotransmitter levels GO:0016199: axon midline choice point recognition GO:0001931: uropod GO:0004500: dopamine beta-monooxygenase activity GO:0045502: dynein binding GO:0070814: hydrogen sulfide biosynthetic process GO:0047273: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity GO:0060687: regulation of branching involved in prostate gland morphogenesis GO:2000124: regulation of endocannabinoid signaling pathway GO:0008489: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity GO:0042135: neurotransmitter catabolic process GO:0046875: ephrin receptor binding GO:0008611: ether lipid biosynthetic process GO:0045907: positive regulation of vasoconstriction GO:0030544: Hsp70 protein binding GO:0046103: inosine biosynthetic process GO:0005776: autophagic vacuole GO:0009880: embryonic pattern specification GO:0045187: regulation of circadian sleep/wake cycle, sleep GO:0045190: isotype switching GO:0051497: negative regulation of stress fiber assembly GO:0032455: nerve growth factor processing GO:0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0003149: membranous septum morphogenesis GO:0001553: luteinization GO:0051041: positive regulation of calcium-independent cell-cell adhesion GO:0070493: thrombin receptor signaling pathway GO:0050667: homocysteine metabolic process GO:0010744: positive regulation of macrophage derived foam cell differentiation GO:0042339: keratan sulfate metabolic process GO:0032902: nerve growth factor production GO:0004601: peroxidase activity GO:0000722: telomere maintenance via recombination GO:0050613: delta14-sterol reductase activity GO:0000038: very long-chain fatty acid metabolic process GO:0006534: cysteine metabolic process GO:0050880: regulation of blood vessel size GO:0022028: tangential migration from the subventricular zone to the olfactory bulb GO:0052547: regulation of peptidase activity GO:0045899: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045806: negative regulation of endocytosis GO:0071222: cellular response to lipopolysaccharide GO:0016601: Rac protein signal transduction GO:0003986: acetyl-CoA hydrolase activity GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0048406: nerve growth factor binding GO:0031982: vesicle GO:0030277: maintenance of gastrointestinal epithelium GO:0005099: Ras GTPase activator activity GO:0048185: activin binding GO:0005976: polysaccharide metabolic process GO:0001875: lipopolysaccharide receptor activity GO:0060907: positive regulation of macrophage cytokine production GO:0016585: chromatin remodeling complex GO:0021847: ventricular zone neuroblast division GO:0009605: response to external stimulus GO:0048244: phytanoyl-CoA dioxygenase activity GO:0001518: voltage-gated sodium channel complex GO:0032507: maintenance of protein location in cell GO:0080146: L-cysteine desulfhydrase activity GO:0021696: cerebellar cortex morphogenesis GO:0055010: ventricular cardiac muscle tissue morphogenesis GO:0001741: XY body GO:0031749: D2 dopamine receptor binding GO:0048853: forebrain morphogenesis GO:0060203: clathrin sculpted glutamate transport vesicle membrane GO:0051925: regulation of calcium ion transport via voltage-gated calcium channel activity GO:0060059: embryonic retina morphogenesis in camera-type eye GO:0033688: regulation of osteoblast proliferation GO:0001662: behavioral fear response GO:0060836: lymphatic endothelial cell differentiation GO:0032589: neuron projection membrane GO:0034374: low-density lipoprotein particle remodeling GO:0046101: hypoxanthine biosynthetic process GO:0003326: pancreatic A cell fate commitment GO:0000188: inactivation of MAPK activity GO:0071504: cellular response to heparin GO:0034587: piRNA metabolic process GO:0061364: apoptosis involved in luteolysis GO:0004602: glutathione peroxidase activity GO:0002636: positive regulation of germinal center formation GO:0017059: serine C-palmitoyltransferase complex GO:0045335: phagocytic vesicle GO:0043395: heparan sulfate proteoglycan binding GO:0043621: protein self-association GO:0048554: positive regulation of metalloenzyme activity GO:0034185: apolipoprotein binding GO:0034046: poly(G) RNA binding GO:0051963: regulation of synaptogenesis GO:0021520: spinal cord motor neuron cell fate specification GO:0043522: leucine zipper domain binding GO:0015485: cholesterol binding GO:0007423: sensory organ development GO:0050910: detection of mechanical stimulus involved in sensory perception of sound GO:0003350: pulmonary myocardium development GO:0005513: detection of calcium ion GO:0016236: macroautophagy GO:0006637: acyl-CoA metabolic process GO:0034109: homotypic cell-cell adhesion GO:0045750: positive regulation of S phase of mitotic cell cycle GO:0016772: transferase activity, transferring phosphorus-containing groups GO:0071672: negative regulation of smooth muscle cell chemotaxis GO:0030857: negative regulation of epithelial cell differentiation GO:0030240: skeletal muscle thin filament assembly GO:0004321: fatty-acyl-CoA synthase activity GO:0033631: cell-cell adhesion mediated by integrin GO:0051973: positive regulation of telomerase activity GO:0019369: arachidonic acid metabolic process GO:0042392: sphingosine-1-phosphate phosphatase activity GO:0006848: pyruvate transport GO:0048013: ephrin receptor signaling pathway GO:0043083: synaptic cleft GO:0001964: startle response GO:0010035: response to inorganic substance GO:0031513: nonmotile primary cilium GO:0048565: digestive tract development GO:0046777: protein autophosphorylation GO:0043616: keratinocyte proliferation GO:0035265: organ growth GO:0055074: calcium ion homeostasis GO:0060595: fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0043257: laminin-8 complex GO:0071229: cellular response to acid GO:0030285: integral to synaptic vesicle membrane GO:0032488: Cdc42 protein signal transduction GO:0006471: protein ADP-ribosylation GO:0005006: epidermal growth factor receptor activity GO:0030323: respiratory tube development GO:0005548: phospholipid transporter activity GO:0060667: branch elongation involved in salivary gland morphogenesis GO:0008273: calcium, potassium:sodium antiporter activity GO:0048791: calcium ion-dependent exocytosis of neurotransmitter GO:0004441: inositol-1,4-bisphosphate 1-phosphatase activity GO:0061001: regulation of dendritic spine morphogenesis GO:0019217: regulation of fatty acid metabolic process GO:0030675: Rac GTPase activator activity GO:0003847: 1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0048268: clathrin coat assembly GO:0010942: positive regulation of cell death GO:0060414: aorta smooth muscle tissue morphogenesis GO:0035604: fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow GO:0045987: positive regulation of smooth muscle contraction GO:0004522: pancreatic ribonuclease activity GO:0008046: axon guidance receptor activity GO:0004716: receptor signaling protein tyrosine kinase activity GO:0034436: glycoprotein transport GO:0002042: cell migration involved in sprouting angiogenesis GO:0051414: response to cortisol stimulus GO:0045569: TRAIL binding GO:0042577: lipid phosphatase activity GO:0007519: skeletal muscle tissue development GO:0002903: negative regulation of B cell apoptosis GO:0043088: regulation of Cdc42 GTPase activity GO:0033484: nitric oxide homeostasis GO:0021860: pyramidal neuron development GO:0021549: cerebellum development GO:0044330: canonical Wnt receptor signaling pathway involved in positive regulation of wound healing GO:0030510: regulation of BMP signaling pathway GO:0031116: positive regulation of microtubule polymerization GO:0060349: bone morphogenesis GO:0048593: camera-type eye morphogenesis GO:0070301: cellular response to hydrogen peroxide GO:0045749: negative regulation of S phase of mitotic cell cycle GO:0090072: positive regulation of sodium ion transport via voltage-gated sodium channel activity GO:0003215: cardiac right ventricle morphogenesis GO:0015307: drug:hydrogen antiporter activity GO:0021631: optic nerve morphogenesis GO:0030849: autosome GO:0035255: ionotropic glutamate receptor binding GO:0009072: aromatic amino acid family metabolic process GO:0050966: detection of mechanical stimulus involved in sensory perception of pain GO:0051297: centrosome organization GO:0051984: positive regulation of chromosome segregation GO:0016167: glial cell line-derived neurotrophic factor receptor activity GO:0010827: regulation of glucose transport GO:0030828: positive regulation of cGMP biosynthetic process GO:0060442: branching involved in prostate gland morphogenesis GO:0030666: endocytic vesicle membrane GO:0030148: sphingolipid biosynthetic process GO:0032024: positive regulation of insulin secretion GO:0001960: negative regulation of cytokine-mediated signaling pathway GO:0043121: neurotrophin binding GO:0010593: negative regulation of lamellipodium assembly GO:0048730: epidermis morphogenesis GO:0060992: response to fungicide GO:0032956: regulation of actin cytoskeleton organization GO:0015227: acyl carnitine transporter activity GO:0071230: cellular response to amino acid stimulus GO:0060201: clathrin sculpted acetylcholine transport vesicle membrane GO:0045576: mast cell activation GO:0021575: hindbrain morphogenesis GO:0005681: spliceosomal complex GO:0032201: telomere maintenance via semi-conservative replication GO:0010468: regulation of gene expression GO:0008542: visual learning GO:0005369: taurine:sodium symporter activity GO:0005815: microtubule organizing center GO:0001975: response to amphetamine GO:0016290: palmitoyl-CoA hydrolase activity GO:0071445: cellular response to protein stimulus GO:0016444: somatic cell DNA recombination GO:0005477: pyruvate secondary active transmembrane transporter activity GO:0050062: long-chain-fatty-acyl-CoA reductase activity GO:0008188: neuropeptide receptor activity GO:0030889: negative regulation of B cell proliferation GO:0007589: body fluid secretion GO:0042627: chylomicron GO:0043006: activation of phospholipase A2 activity by calcium-mediated signaling GO:0048489: synaptic vesicle transport GO:0034380: high-density lipoprotein particle assembly GO:0051412: response to corticosterone stimulus GO:0042584: chromaffin granule membrane GO:0032367: intracellular cholesterol transport GO:2000096: positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway GO:0021836: chemorepulsion involved in postnatal olfactory bulb interneuron migration GO:0048169: regulation of long-term neuronal synaptic plasticity GO:0004713: protein tyrosine kinase activity GO:0070367: negative regulation of hepatocyte differentiation GO:0071363: cellular response to growth factor stimulus GO:0000979: RNA polymerase II core promoter sequence-specific DNA binding GO:0043433: negative regulation of transcription factor activity GO:0007346: regulation of mitotic cell cycle GO:0017134: fibroblast growth factor binding GO:0017156: calcium ion-dependent exocytosis GO:0050690: regulation of defense response to virus by virus GO:0004972: N-methyl-D-aspartate selective glutamate receptor activity GO:0050929: induction of negative chemotaxis GO:0016155: formyltetrahydrofolate dehydrogenase activity GO:0017129: triglyceride binding GO:0045861: negative regulation of proteolysis GO:0044328: canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration GO:0014063: negative regulation of serotonin secretion GO:0050919: negative chemotaxis GO:0021972: corticospinal neuron axon guidance through spinal cord GO:0004502: kynurenine 3-monooxygenase activity GO:0030345: structural constituent of tooth enamel GO:0033993: response to lipid GO:0045666: positive regulation of neuron differentiation GO:0018272: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine GO:0015630: microtubule cytoskeleton GO:0046061: dATP catabolic process GO:0031146: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0071359: cellular response to dsRNA GO:0002158: osteoclast proliferation GO:0007189: activation of adenylate cyclase activity by G-protein signaling pathway GO:0048266: behavioral response to pain GO:0033700: phospholipid efflux GO:0019005: SCF ubiquitin ligase complex GO:0021891: olfactory bulb interneuron development GO:0008344: adult locomotory behavior GO:0010872: regulation of cholesterol esterification GO:0051480: cytosolic calcium ion homeostasis GO:0009720: detection of hormone stimulus GO:0040023: establishment of nucleus localization GO:0061003: positive regulation of dendritic spine morphogenesis GO:0046464: acylglycerol catabolic process GO:0005547: phosphatidylinositol-3,4,5-trisphosphate binding GO:0043186: P granule GO:0034041: sterol-transporting ATPase activity GO:0045499: chemorepellent activity GO:0060056: mammary gland involution GO:0060915: mesenchymal cell differentiation involved in lung development GO:0005250: A-type (transient outward) potassium channel activity GO:0051668: localization within membrane GO:0048488: synaptic vesicle endocytosis GO:0042417: dopamine metabolic process GO:0060029: convergent extension involved in organogenesis GO:0042089: cytokine biosynthetic process GO:0016174: NAD(P)H oxidase activity GO:0060311: negative regulation of elastin catabolic process GO:0010332: response to gamma radiation GO:0042058: regulation of epidermal growth factor receptor signaling pathway GO:0042445: hormone metabolic process GO:0030235: nitric-oxide synthase regulator activity GO:0035555: initiation of Roundabout signal transduction GO:0019344: cysteine biosynthetic process GO:0090007: regulation of mitotic anaphase GO:0021545: cranial nerve development GO:0000096: sulfur amino acid metabolic process GO:0004121: cystathionine beta-lyase activity GO:0051150: regulation of smooth muscle cell differentiation GO:0010875: positive regulation of cholesterol efflux GO:0060045: positive regulation of cardiac muscle cell proliferation GO:0030595: leukocyte chemotaxis GO:0016331: morphogenesis of embryonic epithelium GO:0042059: negative regulation of epidermal growth factor receptor signaling pathway GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway GO:0000730: DNA recombinase assembly GO:0015355: secondary active monocarboxylate transmembrane transporter activity GO:0043274: phospholipase binding GO:0071805: potassium ion transmembrane transport GO:0017146: N-methyl-D-aspartate selective glutamate receptor complex GO:0051017: actin filament bundle assembly GO:0032410: negative regulation of transporter activity GO:0015068: glycine amidinotransferase activity GO:0071300: cellular response to retinoic acid GO:0005248: voltage-gated sodium channel activity GO:0008074: guanylate cyclase complex, soluble GO:0050928: negative regulation of positive chemotaxis GO:0015226: carnitine transporter activity GO:0007140: male meiosis GO:0014047: glutamate secretion GO:0006975: DNA damage induced protein phosphorylation GO:0043408: regulation of MAPKKK cascade GO:0070976: TIR domain binding GO:0046952: ketone body catabolic process GO:0043292: contractile fiber GO:0032091: negative regulation of protein binding GO:0045920: negative regulation of exocytosis GO:0017127: cholesterol transporter activity GO:0008815: citrate (pro-3S)-lyase activity GO:0010952: positive regulation of peptidase activity GO:0007157: heterophilic cell-cell adhesion GO:0051605: protein maturation by peptide bond cleavage GO:0004677: DNA-dependent protein kinase activity GO:0042063: gliogenesis GO:0010044: response to aluminum ion GO:0071777: positive regulation of cell cycle cytokinesis GO:0014051: gamma-aminobutyric acid secretion GO:0006968: cellular defense response GO:0035108: limb morphogenesis GO:0050544: arachidonic acid binding GO:0043113: receptor clustering GO:0030888: regulation of B cell proliferation GO:0090260: negative regulation of retinal ganglion cell axon guidance GO:0004016: adenylate cyclase activity GO:0047372: acylglycerol lipase activity GO:0031659: positive regulation of cyclin-dependent protein kinase activity involved in G1/S GO:0090288: negative regulation of cellular response to growth factor stimulus GO:0032497: detection of lipopolysaccharide GO:0030644: cellular chloride ion homeostasis GO:0050693: LBD domain binding GO:0031532: actin cytoskeleton reorganization GO:0032808: lacrimal gland development GO:0043981: histone H4-K5 acetylation GO:0033278: cell proliferation in midbrain GO:0051058: negative regulation of small GTPase mediated signal transduction GO:0017158: regulation of calcium ion-dependent exocytosis GO:0007431: salivary gland development GO:0048608: reproductive structure development GO:0046619: optic placode formation involved in camera-type eye formation GO:0010212: response to ionizing radiation GO:0051585: negative regulation of dopamine uptake GO:0008131: primary amine oxidase activity GO:0019363: pyridine nucleotide biosynthetic process GO:0007276: gamete generation GO:0051597: response to methylmercury GO:0005958: DNA-dependent protein kinase-DNA ligase 4 complex GO:0003329: pancreatic PP cell fate commitment GO:0010886: positive regulation of cholesterol storage GO:0060039: pericardium development GO:0055100: adiponectin binding GO:0016600: flotillin complex GO:0006907: pinocytosis GO:0071547: piP-body GO:0004710: MAP/ERK kinase kinase activity GO:0003956: NAD(P)+-protein-arginine ADP-ribosyltransferase activity GO:0042524: negative regulation of tyrosine phosphorylation of Stat5 protein GO:0033327: Leydig cell differentiation GO:0021754: facial nucleus development GO:0015057: thrombin receptor activity GO:0005121: Toll binding GO:0006465: signal peptide processing GO:0009651: response to salt stress GO:0047961: glycine N-acyltransferase activity GO:0015491: cation:cation antiporter activity GO:0060449: bud elongation involved in lung branching GO:0051622: negative regulation of norepinephrine uptake GO:0008406: gonad development GO:0060612: adipose tissue development GO:0001517: N-acetylglucosamine 6-O-sulfotransferase activity GO:0001561: fatty acid alpha-oxidation GO:2000016: negative regulation of determination of dorsal identity GO:0006904: vesicle docking involved in exocytosis GO:0030122: AP-2 adaptor complex GO:0016742: hydroxymethyl-, formyl- and related transferase activity GO:0050902: leukocyte adhesive activation GO:0031047: gene silencing by RNA GO:0006261: DNA-dependent DNA replication GO:0071456: cellular response to hypoxia GO:0050692: DBD domain binding GO:0070876: SOSS complex GO:0006584: catecholamine metabolic process GO:0035249: synaptic transmission, glutamatergic GO:0001669: acrosomal vesicle GO:0021679: cerebellar molecular layer development GO:0032569: gene-specific transcription from RNA polymerase II promoter GO:0045773: positive regulation of axon extension GO:0010269: response to selenium ion GO:0010721: negative regulation of cell development GO:0006725: cellular aromatic compound metabolic process GO:0030273: melanin-concentrating hormone receptor activity GO:0070328: triglyceride homeostasis GO:0007387: anterior compartment pattern formation GO:0032314: regulation of Rac GTPase activity GO:0030349: syntaxin-13 binding GO:0010551: regulation of gene-specific transcription from RNA polymerase II promoter GO:0060205: cytoplasmic membrane-bounded vesicle lumen GO:0010887: negative regulation of cholesterol storage GO:0030117: membrane coat GO:0050671: positive regulation of lymphocyte proliferation GO:0048541: Peyer's patch development GO:0051612: negative regulation of serotonin uptake GO:0043069: negative regulation of programmed cell death GO:0002027: regulation of heart rate GO:0030146: diuresis GO:0050927: positive regulation of positive chemotaxis GO:0034103: regulation of tissue remodeling GO:0050775: positive regulation of dendrite morphogenesis GO:0033563: dorsal/ventral axon guidance GO:0010890: positive regulation of sequestering of triglyceride GO:0080008: CUL4 RING ubiquitin ligase complex GO:0007499: ectoderm and mesoderm interaction GO:0060313: negative regulation of blood vessel remodeling GO:0016830: carbon-carbon lyase activity GO:0042986: positive regulation of amyloid precursor protein biosynthetic process GO:0045019: negative regulation of nitric oxide biosynthetic process GO:0043548: phosphatidylinositol 3-kinase binding GO:0021750: vestibular nucleus development GO:0007616: long-term memory GO:0060849: regulation of transcription involved in lymphatic endothelial cell fate commitment GO:0005607: laminin-2 complex GO:0043206: fibril organization GO:0048846: axon extension involved in axon guidance GO:0015697: quaternary ammonium group transport GO:0018146: keratan sulfate biosynthetic process GO:0030193: regulation of blood coagulation GO:0051964: negative regulation of synaptogenesis GO:0006983: ER overload response GO:0006790: sulfur compound metabolic process GO:0006283: transcription-coupled nucleotide-excision repair GO:0060615: mammary gland bud formation GO:0003322: pancreatic A cell development GO:0061037: negative regulation of cartilage development GO:0032747: positive regulation of interleukin-23 production GO:0009346: citrate lyase complex GO:0015347: sodium-independent organic anion transmembrane transporter activity GO:0015375: glycine:sodium symporter activity GO:0034437: glycoprotein transporter activity GO:0045080: positive regulation of chemokine biosynthetic process GO:0071902: positive regulation of protein serine/threonine kinase activity GO:0031694: alpha-2A adrenergic receptor binding GO:0016486: peptide hormone processing GO:0042327: positive regulation of phosphorylation GO:0042997: negative regulation of Golgi to plasma membrane protein transport GO:0043983: histone H4-K12 acetylation GO:0035603: fibroblast growth factor receptor signaling pathway involved in hemopoiesis GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0008610: lipid biosynthetic process GO:0008266: poly(U) RNA binding GO:0005123: death receptor binding GO:0033344: cholesterol efflux GO:0045717: negative regulation of fatty acid biosynthetic process GO:0070652: HAUS complex GO:0001843: neural tube closure GO:0035607: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0070100: negative regulation of chemokine-mediated signaling pathway GO:0006844: acyl carnitine transport GO:0070858: negative regulation of bile acid biosynthetic process GO:0043114: regulation of vascular permeability GO:0048495: Roundabout binding GO:0043982: histone H4-K8 acetylation GO:0030215: semaphorin receptor binding GO:0007128: meiotic prophase I GO:0005030: neurotrophin receptor activity GO:0006271: DNA strand elongation involved in DNA replication GO:0008306: associative learning GO:0010350: cellular response to magnesium starvation GO:0030288: outer membrane-bounded periplasmic space GO:0045600: positive regulation of fat cell differentiation GO:0090136: epithelial cell-cell adhesion GO:0007256: activation of JNKK activity GO:0021590: cerebellum maturation GO:0090083: regulation of inclusion body assembly GO:0005326: neurotransmitter transporter activity GO:0001101: response to acid GO:0032914: positive regulation of transforming growth factor-beta1 production GO:0004758: serine C-palmitoyltransferase activity GO:0001950: plasma membrane enriched fraction GO:0000790: nuclear chromatin GO:0008184: glycogen phosphorylase activity GO:0071425: hemopoietic stem cell proliferation GO:0046618: drug export GO:0030032: lamellipodium assembly GO:0048066: developmental pigmentation GO:0042640: anagen GO:0044329: canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion GO:0003148: outflow tract septum morphogenesis GO:0032261: purine nucleotide salvage GO:0014823: response to activity GO:0002238: response to molecule of fungal origin GO:0007158: neuron cell-cell adhesion GO:0010040: response to iron(II) ion GO:0060407: negative regulation of penile erection GO:0010642: negative regulation of platelet-derived growth factor receptor signaling pathway GO:0051902: negative regulation of mitochondrial depolarization GO:0044424: intracellular part GO:0031177: phosphopantetheine binding GO:0042582: azurophil granule GO:0016291: acyl-CoA thioesterase activity GO:0004708: MAP kinase kinase activity GO:0006601: creatine biosynthetic process GO:0060670: branching involved in embryonic placenta morphogenesis GO:0007159: leukocyte cell-cell adhesion GO:0010711: negative regulation of collagen catabolic process GO:0003151: outflow tract morphogenesis GO:0042312: regulation of vasodilation GO:0045197: establishment or maintenance of epithelial cell apical/basal polarity GO:0000060: protein import into nucleus, translocation GO:0003851: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity GO:0070435: Shc-EGFR complex GO:0031576: G2/M transition checkpoint GO:0001836: release of cytochrome c from mitochondria GO:0030977: taurine binding GO:0071813: lipoprotein particle binding GO:0031394: positive regulation of prostaglandin biosynthetic process GO:0043405: regulation of MAP kinase activity GO:0030119: AP-type membrane coat adaptor complex GO:0043208: glycosphingolipid binding GO:0001736: establishment of planar polarity GO:0071407: cellular response to organic cyclic compound GO:0030916: otic vesicle formation GO:0008294: calcium- and calmodulin-responsive adenylate cyclase activity GO:0061202: clathrin sculpted gamma-aminobutyric acid transport vesicle membrane GO:0034765: regulation of ion transmembrane transport GO:0070372: regulation of ERK1 and ERK2 cascade GO:0032792: negative regulation of CREB transcription factor activity GO:0001967: suckling behavior GO:0008513: secondary active organic cation transmembrane transporter activity GO:0032926: negative regulation of activin receptor signaling pathway GO:0060529: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:0032353: negative regulation of hormone biosynthetic process GO:0007199: G-protein signaling, coupled to cGMP nucleotide second messenger GO:0002906: negative regulation of mature B cell apoptosis GO:0048015: phosphatidylinositol-mediated signaling GO:0009314: response to radiation GO:0060429: epithelium development GO:0042747: circadian sleep/wake cycle, REM sleep GO:0050702: interleukin-1 beta secretion GO:0015949: nucleobase, nucleoside and nucleotide interconversion GO:0071679: commissural neuron axon guidance GO:0055009: atrial cardiac muscle tissue morphogenesis GO:0055096: low-density lipoprotein particle mediated signaling GO:0002689: negative regulation of leukocyte chemotaxis GO:0010703: negative regulation of histolysis GO:0006944: cellular membrane fusion GO:0043620: regulation of transcription in response to stress GO:0071676: negative regulation of mononuclear cell migration GO:0046882: negative regulation of follicle-stimulating hormone secretion GO:0016576: histone dephosphorylation GO:0005152: interleukin-1 receptor antagonist activity GO:0008260: 3-oxoacid CoA-transferase activity GO:0048762: mesenchymal cell differentiation GO:0048841: regulation of axon extension involved in axon guidance GO:0010517: regulation of phospholipase activity GO:0055106: ubiquitin-protein ligase regulator activity GO:0009967: positive regulation of signal transduction GO:0042094: interleukin-2 biosynthetic process GO:0005251: delayed rectifier potassium channel activity GO:0070830: tight junction assembly GO:0005109: frizzled binding GO:0070495: negative regulation of thrombin receptor signaling pathway GO:0032740: positive regulation of interleukin-17 production GO:0005522: profilin binding GO:0045964: positive regulation of dopamine metabolic process GO:0042805: actinin binding GO:0042987: amyloid precursor protein catabolic process GO:0050883: musculoskeletal movement, spinal reflex action GO:0004334: fumarylacetoacetase activity GO:0005007: fibroblast growth factor receptor activity GO:0007243: intracellular protein kinase cascade GO:0030282: bone mineralization GO:0050432: catecholamine secretion GO:0035067: negative regulation of histone acetylation GO:0071287: cellular response to manganese ion GO:0005657: replication fork GO:0001554: luteolysis GO:0030118: clathrin coat GO:0031045: dense core granule GO:0035413: positive regulation of catenin import into nucleus GO:0006157: deoxyadenosine catabolic process GO:0071396: cellular response to lipid GO:0032584: growth cone membrane GO:0050850: positive regulation of calcium-mediated signaling GO:0010460: positive regulation of heart rate GO:0043199: sulfate binding GO:0010453: regulation of cell fate commitment GO:0031267: small GTPase binding GO:0007388: posterior compartment specification GO:0006303: double-strand break repair via nonhomologous end joining GO:0022612: gland morphogenesis GO:0051798: positive regulation of hair follicle development GO:0043537: negative regulation of blood vessel endothelial cell migration GO:0001829: trophectodermal cell differentiation GO:0032277: negative regulation of gonadotropin secretion GO:0015651: quaternary ammonium group transmembrane transporter activity GO:0005068: transmembrane receptor protein tyrosine kinase adaptor activity GO:0015012: heparan sulfate proteoglycan biosynthetic process GO:0051443: positive regulation of ubiquitin-protein ligase activity GO:0042272: nuclear RNA export factor complex GO:0048286: lung alveolus development GO:0010633: negative regulation of epithelial cell migration GO:0060601: lateral sprouting from an epithelium GO:0002244: hemopoietic progenitor cell differentiation GO:0060155: platelet dense granule organization GO:0006171: cAMP biosynthetic process GO:0015802: basic amino acid transport GO:0019907: cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0048041: focal adhesion assembly GO:0002088: lens development in camera-type eye GO:0005662: DNA replication factor A complex GO:0001780: neutrophil homeostasis GO:0008045: motor axon guidance GO:0050862: positive regulation of T cell receptor signaling pathway Supplementary Table S3. Pathway analysis by Oncobox.

Pathway .10_7xIR..1.10_7xIR..2.10_7xIR..31051_.7xIR1051_.7xIR1051_.7xIR1063_7xIR.1063_7xIR.1063_7xIR.1083_7xIR.1083_7xIR.1083_7xIR..1043_IR_1.1043_IR_2.1043_IR_3.1095_IR_1.1095_IR_2.1095_IR_3p_val p_fdr biocarta_role_of_mitochondria_in_apoptotic_sign -0,14958 0,108168 -0,22839 1,066769 0,815433 0,939422 -0,62127 -0,44727 -0,70964 -0,77647 0,443428 -1,0938 1,156836 0,660353 0,72009 -0,53909 -0,11533 -0,30738 2,08E-05 0,023558 NCI_Endogenous_TLR_signaling_Pathway_(cytoki 0,086121 -0,00234 0,018757 -1,03223 -0,96908 -1,15655 -1,6764 -1,48645 -1,32862 0,624465 1,010173 0,813516 -0,40502 -1,22289 -0,58846 0,169557 -0,33177 -0,0985 7,59E-05 0,023558 NCI_p75_NTR_mediated_signaling_Pathway_(neu -0,27754 -0,20711 -0,20661 0,250039 0,012991 0,86211 -1,46744 -1,47759 -1,31897 -1,08826 -0,86972 -1,63209 0,533027 0,115468 0,420156 -0,81953 -1,07129 -0,81789 8,32E-05 0,023558 NCI_PAR1_mediated_thrombin_signaling_events_ 0,019679 -0,04977 -0,08242 0,611616 0,307613 0,202424 -0,26641 -0,17778 -0,45536 -0,33794 -0,22197 -0,57981 0,165406 0,28673 0,214814 -0,62542 -0,34248 -0,28117 6,91E-05 0,023558 NCI_PAR1_mediated_thrombin_signaling_events_ 0,019679 -0,04977 -0,08242 0,611616 0,307613 0,202424 -0,26641 -0,17778 -0,45536 -0,33794 -0,22197 -0,57981 0,165406 0,28673 0,214814 -0,62542 -0,34248 -0,28117 6,91E-05 0,023558 NCI_PAR4_mediated_thrombin_signaling_events_ 0,019679 -0,04977 -0,08242 0,611616 0,307613 0,202424 -0,26641 -0,17778 -0,45536 -0,33794 -0,22197 -0,57981 0,165406 0,28673 0,214814 -0,62542 -0,34248 -0,28117 6,91E-05 0,023558 NCI_PAR4_mediated_thrombin_signaling_events_ 0,019679 -0,04977 -0,08242 0,611616 0,307613 0,202424 -0,26641 -0,17778 -0,45536 -0,33794 -0,22197 -0,57981 0,165406 0,28673 0,214814 -0,62542 -0,34248 -0,28117 6,91E-05 0,023558 NCI_Validated_targets_of_C_MYC_transcriptional -0,10294 -0,10014 -0,19995 0,133095 0,522621 0,511793 -0,68228 -0,69148 -0,95971 -0,24867 -0,08747 0,032876 0,335442 0,251899 0,490359 -0,86282 -0,39003 -0,25377 7,59E-05 0,023558 NCI_Validated_targets_of_C_MYC_transcriptional -0,09933 -0,17385 -0,01442 0,352699 1,168318 1,186986 0,190536 0,432512 -0,08448 -0,46136 -0,64404 -1,21231 0,633951 0,55121 0,433488 -1,17807 -0,42777 -0,48906 6,18E-05 0,023558 NCI_Validated_targets_of_C_MYC_transcriptional -0,0671 -0,07652 -0,05544 0,490381 1,157492 1,287886 -0,32805 -0,08286 -0,57644 -0,86208 -0,56088 -1,48117 0,421759 0,629012 0,530508 -1,87506 -0,67736 -0,99081 7,95E-05 0,023558 reactome_Glucuronidation_Main_Pathway 0,025845 0,460018 0,517806 -2,89741 -3,77714 -3,90748 2,564328 2,89228 3,803521 -0,48118 1,50309 2,955202 -0,85483 -2,34056 -3,63005 4,376273 5,064022 1,795472 6,00E-05 0,023558 KEGG_Drug_metabolism_cytochrome_P450_Main -0,13804 0,990738 0,662211 -3,11624 -3,45942 -5,35979 2,963668 2,628548 4,71111 1,749441 1,011775 4,060237 -1,19282 -3,06558 -4,31368 7,955511 6,624248 2,135931 0,000101 0,026335 KEGG_Ascorbate_and_aldarate_metabolism_Mai -0,13352 0,330468 0,478069 -2,8865 -3,36696 -4,13266 2,755773 2,889777 4,080533 -0,05015 1,02921 2,376087 -0,91114 -2,88301 -3,94868 5,370974 5,964281 1,837368 0,000123 0,027302 reactome_CDO_in_myogenesis_Main_Pathway -0,15813 -0,51278 -0,55066 2,206044 2,002585 1,134712 -1,14989 -1,05512 -1,7197 -1,37334 0,827326 -1,30725 0,714101 0,747423 1,266129 -0,44645 -1,06352 -0,88965 0,000117 0,027302 KEGG_Drug_metabolism_other_enzymes_Main_P 0,120452 0,52913 0,582473 -3,24965 -3,01768 -5,73682 1,848922 1,98581 3,624067 0,37784 1,507251 3,642203 -0,6024 -3,38571 -3,78879 5,163789 5,110386 0,050567 0,000159 0,033069 biocarta_lck_and_fyn_tyrosine_kinases_in_initiati -0,13071 0,253825 0,005441 -0,29007 -0,3834 0,068962 0,091746 -0,05249 0,685173 0,962416 0,885057 0,857877 -0,37971 -0,80498 -0,4006 0,902364 0,811811 1,30082 0,000204 0,035303 KEGG_Pentose_and_glucuronate_interconversion 0,079856 0,381208 0,398672 -4,22015 -3,9356 -6,15747 3,025307 3,180203 4,339421 -0,59183 1,22191 3,601359 -1,22485 -2,78095 -4,10165 2,135802 3,110858 -1,08992 0,000192 0,035303 reactome_SMAD2_SMAD3_SMAD4_heterotrimer 0,007194 -0,19804 -0,20729 2,29621 1,396153 1,390724 0,917773 1,006106 0,29095 -2,4387 -1,01322 -0,53424 0,540811 0,599254 0,561005 -2,7353 -2,05831 -1,19866 0,000204 0,035303 D-imyoi-inositol_3456-tetrakisphosphate_biosynth -0,08352 -0,12952 -0,10782 0,101265 0,466747 0,107686 -0,13454 -0,14139 -0,19234 -0,2983 -0,49885 -0,56025 0,067663 0,167081 -0,02826 -0,52579 -0,45567 -0,33528 0,00027 0,042085 NCI_Endogenous_TLR_signaling_Main_Pathway -0,2083 -0,03639 -0,22704 -0,49885 -0,94217 -1,34238 -3,6623 -3,40708 -3,125 2,978254 1,761968 1,199439 -1,11914 -1,88658 -0,6393 0,993109 1,135343 1,010564 0,00027 0,042085 NCI_Alpha6_beta4_integrin_ligand_interactions_M -0,15731 -0,1499 0,014382 -0,66008 -0,42603 -0,28668 -2,41016 -2,54263 -2,39151 1,262325 0,677398 0,772455 -0,47859 -0,40212 -0,45949 0,72908 0,651952 0,440399 0,000315 0,043668 NCI_LKB1_signaling_events_Pathway_(anoikis) 0,005985 -0,08613 -0,09867 0,595473 0,473353 0,097747 0,116104 0,081546 0,073613 -0,35051 0,051694 0,270603 0,435181 0,581987 0,577376 -0,41423 -0,79423 -0,72186 0,000322 0,043668 nicotine_degradation_IV -0,18208 0,226515 0,075623 -0,64075 -0,74805 -0,06078 1,129096 0,610115 1,250764 1,465354 0,304847 0,622721 -0,56572 -1,35889 -0,87041 1,698355 1,00742 0,306358 0,00035 0,043668 reactome_Constitutive_Signaling_by_NOTCH1_t_ 0,076846 0,029433 0,011175 0,529984 0,132957 0,246417 -0,87899 -0,79353 -1,04301 -0,20202 -0,00532 0,095628 0,49823 0,5019 0,632352 -0,68201 -0,45136 -0,20687 0,000337 0,043668 KEGG_Steroid_hormone_biosynthesis_Main_Path -0,02577 0,197042 0,378945 -3,15392 -4,14888 -6,04125 3,168002 2,092591 5,085098 3,921736 0,568529 4,433452 -0,24727 -2,67164 -3,19856 8,062275 8,211785 2,583512 0,000368 0,044069 NCI_Regulation_of_retinoblastoma_protein_Path -0,10954 -0,14345 -0,13561 0,043855 0,580864 -0,00318 0,644247 0,750113 0,556679 -0,83082 -0,67201 -1,00326 0,231162 0,164172 0,182089 -0,25511 -0,66023 -0,35737 0,000391 0,045106 KEGG_Notch_signaling_Main_Pathway -0,20097 0,095694 0,005506 1,078425 1,762794 1,556184 0,34296 0,796908 0,276213 -0,64188 -1,61999 -1,48763 1,394343 1,212587 1,50736 0,609676 0,207714 1,037677 0,000418 0,046547 reactome_p75NTR_negatively_regulates_cell_cyc -0,04891 -0,11963 -0,01519 -0,04347 0,470543 0,278272 -0,05932 -0,04684 -0,16922 -0,22044 -0,09581 -0,54784 0,659449 0,303915 0,593984 -1,08909 -0,9484 -0,78554 0,000484 0,05203 reactome_Amine_ligand_binding_receptors_Main -0,17773 0,123431 0,07145 -0,43871 -2,2026 -0,82668 0,537068 0,404957 0,676779 2,546742 1,754658 0,954531 -0,7921 -0,30954 -0,41963 2,077395 1,913025 1,346004 0,00051 0,052997 reactome_Eicosanoids_Main_Pathway 0,365536 0,515161 0,745429 -0,65605 -0,50885 -0,88069 -1,15745 -1,359 -0,03347 2,420064 1,826808 1,728255 0,43609 0,052085 0,643681 2,65259 2,043616 1,664627 0,000579 0,058169 biocarta_mets_affect_on_macrophage_differentia 0,036197 -0,01315 -0,13217 1,037661 0,803225 0,847009 0,268184 0,292248 -0,44865 -1,84305 -1,11256 -1,46049 0,173162 0,008597 0,364986 -2,11522 -0,98502 -0,44673 0,000633 0,058487 KEGG_Olfactory_transduction_Main_Pathway -11,3492 6,284344 1,503138 -30,7025 -29,1757 -30,8379 58,87917 50,87613 79,40178 73,48898 26,15869 36,61434 -11,6201 -19,6467 -20,1876 92,49403 70,00201 54,87789 0,000695 0,058487 NCI_PAR4_mediated_thrombin_signaling_events_ -0,21913 -0,4352 -0,37696 0,599243 0,582132 -0,01463 -2,12487 -2,07685 -2,14323 -0,74618 0,00954 -0,97181 -0,0592 0,392387 0,703571 -1,21648 -0,52496 -0,00314 0,000694 0,058487 reactome_Olfactory_Signaling_Pathway_Main_Pa -10,9742 5,953928 1,559817 -30,0493 -29,3336 -31,5494 56,35148 49,2017 76,91683 70,61092 27,39566 32,78875 -11,2339 -18,0166 -19,4064 88,65726 67,43098 55,12345 0,000631 0,058487 reactome_Synthesis_of_Leukotrienes_LT_and_Eo 0,328151 0,322715 1,044423 -0,80719 -1,31864 -0,6823 -0,83106 -1,15237 -0,01706 1,312519 0,696789 1,220214 0,25169 -0,26002 0,241687 1,925048 2,355245 1,025418 0,000675 0,058487 WNT_Pathway_Cytoskeletal_Rearrangement 0,028669 -0,0038 0,103743 0,583932 0,316612 0,397951 -0,37588 -0,23914 -0,43943 0,10985 -0,09449 -0,24 0,379035 0,256914 0,349731 -0,5388 -0,90552 -0,51975 0,000656 0,058487 Akt_Signaling_Pathway_Translation 0,139073 -0,03523 -0,0191 0,583866 0,370625 0,170789 -0,09719 0,05474 -0,5335 -0,21271 -0,40911 0,039746 0,301562 0,56512 0,574113 -1,24218 -0,72418 -0,51335 0,000718 0,058681 NCI_Regulation_of_retinoblastoma_protein_Path -0,21649 -0,36956 -0,21664 -0,22505 1,023669 -0,20141 1,64917 1,726205 1,569944 -2,45084 -1,66407 -1,95802 0,599669 0,317547 0,55966 -0,87251 -1,40661 -0,92173 0,000735 0,058681 reactome_PERK_regulates_gene_expression_Mai 0,050748 0,005902 -0,02154 0,512705 0,852566 0,436077 -0,17849 -0,1351 -0,38047 -0,40515 -0,17814 -0,41943 0,188279 0,182338 0,116177 -1,11182 -0,93274 -0,55004 0,000804 0,062645 JNK_Pathway_Gene_Expression_Apoptosis_Inflam -0,00433 -0,38992 -0,64879 2,290071 2,633478 0,724178 -1,05136 -0,83246 -1,34451 -4,78878 0,806943 -1,75191 1,764831 1,689732 3,218764 -1,21348 -2,93488 1,162334 0,000908 0,062851 KEGG_Metabolism_of_xenobiotics_by_cytochrom -0,79504 0,756295 0,161347 -6,91693 -5,58795 -7,26504 2,730761 1,541534 5,95265 2,724735 1,525547 5,963418 -0,14277 -1,2099 -4,05333 8,515152 7,44621 1,686386 0,000862 0,062851 NCI_BCR_signaling_Pathway_(ubiquitin_depende 0,2597 -0,11881 -0,11159 -0,22924 0,551391 0,518126 -0,82616 -0,62191 -1,28819 -0,93155 -0,92756 -0,9328 0,933244 0,146505 0,427983 -1,68723 -1,52785 -1,56651 0,000894 0,062851 NCI_S1P1_Pathway_(receptor_internalization) -0,02394 -0,22016 -0,07383 1,135508 0,7722 0,689745 -0,18266 -0,03355 -0,12493 -0,01756 -0,69974 -1,46546 0,021828 0,334005 0,296165 -1,39366 -0,5581 -0,34986 0,000828 0,062851 reactome_NRAGE_signals_death_through_JNK_M -0,04743 -0,76402 -0,36868 0,330815 1,813705 1,080477 -2,88199 -2,92077 -3,76756 -6,16635 -1,50951 -1,72992 1,03784 2,095558 1,516638 -3,54119 -1,59117 -0,86652 0,000906 0,062851 spermine_biosynthesis 0,04948 -0,02335 -0,04708 0,114467 -0,00984 0,22599 -0,27034 -0,25137 -0,411 -0,46226 -0,12777 -0,51907 0,295483 0,156952 0,217575 -0,67296 -0,19036 -0,21378 0,000957 0,064808 1D-imyoi-inositol_hexakisphosphate_biosynthesis -0,05598 -0,14298 -0,10449 0,106725 0,610874 0,159464 -0,35097 -0,3615 -0,49166 0,120707 -0,6478 -0,40829 0,223166 0,23516 0,000255 -0,73117 -0,68576 -0,38208 0,001053 0,067945 biocarta_granzyme_a_mediated_apoptosis_Main_ -0,04572 0,153472 0,305432 0,807314 0,872632 0,307348 0,18121 0,247863 0,554305 -1,38217 -0,55537 -0,56473 0,465972 0,438177 0,517028 -1,15294 -0,13754 0,046203 0,001178 0,067945 KEGG_Neurotrophin_signaling_Main_Pathway -0,03477 -1,68897 -1,32481 1,102899 2,25409 2,313286 -9,6683 -8,50106 -11,6057 -4,6522 -2,8921 -0,25957 1,955569 0,915712 3,304433 -10,7347 -7,31779 -4,24741 0,001133 0,067945 NCI_Regulation_of_retinoblastoma_protein_Main -0,09914 -0,43692 -0,49653 -0,22322 0,96223 0,316304 2,117785 2,463083 1,206526 -2,89433 -1,68661 -3,98987 0,942549 1,012485 1,148319 -5,82288 -3,80331 -2,62108 0,001057 0,067945 NCI_Regulation_of_retinoblastoma_protein_Path -0,12005 -0,26703 -0,17133 -0,07151 0,695636 0,712599 1,533365 1,638233 1,149673 -1,45539 -0,55618 -1,98669 0,094811 0,348145 0,486296 -2,66477 -1,51943 -0,74442 0,001166 0,067945 reactome_Constitutive_Signaling_by_NOTCH1_HD 0,298436 -0,25875 -0,3051 0,126271 0,858802 0,431607 -1,52422 -1,26603 -2,41204 -4,15988 -1,31995 -3,35808 2,209234 1,378743 2,297405 -6,8966 -4,02761 -2,87834 0,001164 0,067945 reactome_Constitutive_Signaling_by_NOTCH1_PE 0,298436 -0,25875 -0,3051 0,126271 0,858802 0,431607 -1,52422 -1,26603 -2,41204 -4,15988 -1,31995 -3,35808 2,209234 1,378743 2,297405 -6,8966 -4,02761 -2,87834 0,001164 0,067945 reactome_Purine_salvage_Main_Pathway 0,201878 -0,16699 -0,14844 0,619927 0,684092 0,825656 0,517687 0,852412 0,136251 -1,46183 -0,6593 -1,414 0,413967 0,695533 0,7728 -3,37788 -2,41143 -2,1471 0,001167 0,067945 NCI_Regulation_of_cytoplasmic_and_nuclear_SM -0,08855 -0,21052 -0,13954 0,779189 0,162475 0,416762 -0,13051 0,077696 -0,31168 -1,26013 0,224929 -0,31913 0,698156 0,912181 0,77938 -2,27264 -1,81738 -0,65942 0,001308 0,068906 NCI_Regulation_of_retinoblastoma_protein_Path -0,2356 -0,2792 -0,24783 -0,19397 0,953893 0,502318 1,623572 1,81446 1,272483 -1,46621 -1,08214 -2,90334 0,255125 0,416766 0,529936 -1,66293 -0,979 -0,31409 0,001223 0,068906 reactome_Anchoring_fibril_formation_Main_Path -0,12521 0,056589 -0,00343 -0,16972 -0,03197 -0,23793 -0,34059 -0,63405 0,049337 0,223533 0,408195 0,6631 -0,46774 -0,29023 -0,59576 1,32651 0,715208 0,891051 0,001245 0,068906 reactome_Constitutive_PI3K_AKT_Signaling_in_Ca 0,157193 -0,39356 -0,14151 0,160252 1,616971 0,437152 -0,737 -0,44209 -1,57623 -1,08606 0,581818 -1,58985 1,079349 0,886195 0,842736 -2,93566 -2,39996 -1,56985 0,001327 0,068906 reactome_NICD_traffics_to_nucleus_Main_Pathw -0,0618 -0,14062 -0,15022 0,118538 0,34086 -0,23949 0,22223 0,296818 0,048155 -1,88116 -0,9171 -0,72768 0,582068 0,032983 0,534229 -1,88633 -1,63538 -1,08067 0,001301 0,068906 reactome_Notch_HLH_transcription_Main_Pathw -0,0618 -0,14062 -0,15022 0,118538 0,34086 -0,23949 0,22223 0,296818 0,048155 -1,88116 -0,9171 -0,72768 0,582068 0,032983 0,534229 -1,88633 -1,63538 -1,08067 0,001301 0,068906 fatty_acid_alpha-oxidation_III -0,06648 -0,0885 0,008094 0,220667 0,050827 -0,10399 -0,30593 -0,29298 -0,40153 -0,48725 -0,48879 -0,18898 0,2093 0,066637 0,21226 -0,67509 -0,4079 -0,12668 0,001377 0,069186 nicotine_degradation_III -0,06118 -0,02273 0,017201 -0,63329 -0,26033 -0,10979 0,429827 0,156758 0,503847 0,338642 0,365656 0,761372 -0,15839 -0,77159 -0,42063 0,944909 1,236017 -0,01459 0,001359 0,069186 reactome_Regulation_of_Commissural_axon_pat -0,02606 -0,01774 0,010192 0,093097 -0,23232 -0,1739 -0,64778 -0,53657 -0,6346 0,474807 0,927902 0,585954 -0,58379 -0,09774 -0,39027 0,229682 0,527525 0,456529 0,001499 0,074116 Notch_Signaling_Pathway 0,251148 0,09231 0,058026 0,576489 1,954441 0,70865 0,831535 1,291969 0,691204 0,023926 0,139553 0,114096 1,21983 1,101441 1,255149 -2,45699 -2,00916 -2,11191 0,001555 0,075686 KEGG_Retinol_metabolism_Main_Pathway -0,85789 0,78026 0,881948 -7,03031 -5,83958 -8,57198 3,463409 2,658617 6,850481 5,470389 3,484999 7,576409 1,555333 -0,79091 -2,38318 12,55381 11,32114 5,00261 0,001677 0,08037 biocarta_akt_signaling_Main_Pathway -0,05334 -0,08606 -0,29587 0,309295 0,351091 0,449635 1,279718 1,228955 1,14464 -0,84878 0,21499 0,616217 0,77711 0,796107 1,064824 -0,7426 -0,25754 0,339898 0,002602 0,081203 biocarta_hypoxia_and_p53_in_the_cardiovascula 0,17616 -0,29347 -0,16128 0,995311 1,833722 1,379115 -0,14587 0,090261 -0,59405 -0,2871 -0,31218 -0,7454 0,323202 0,149647 0,159592 -3,32215 -2,07477 -1,80674 0,002699 0,081203 biocarta_il_4_signaling_Pathway_(cell_proliferatio 0,034625 0,402553 0,247747 -0,63952 0,08901 0,27129 0,255358 0,254547 0,803402 1,261456 0,70245 1,314242 0,220025 -0,28737 -0,16291 0,783041 1,223914 0,459649 0,002358 0,081203 biocarta_mechanisms_of_transcriptional_repress -0,03054 -0,12557 -0,17822 -0,19169 0,440566 0,059669 1,178278 1,27771 0,911492 -2,3437 -1,073 -1,42199 0,276079 0,205857 0,116233 -2,71955 -1,85796 -1,96015 0,00237 0,081203 biocarta_mechanisms_of_transcriptional_repress -0,03054 -0,12557 -0,17822 -0,19169 0,440566 0,059669 1,178278 1,27771 0,911492 -2,3437 -1,073 -1,42199 0,276079 0,205857 0,116233 -2,71955 -1,85796 -1,96015 0,00237 0,081203 biocarta_opposing_roles_of_aif_in_apoptosis_and 0,027813 0,017365 0,019108 0,246402 0,259977 0,248602 0,655175 0,681736 0,581776 -0,03294 -0,16302 -0,36222 0,210812 0,002706 0,166177 -0,81443 -0,6909 -0,41914 0,002472 0,081203 biocarta_opposing_roles_of_aif_in_apoptosis_and 0,027813 0,017365 0,019108 0,246402 0,259977 0,248602 0,655175 0,681736 0,581776 -0,03294 -0,16302 -0,36222 0,210812 0,002706 0,166177 -0,81443 -0,6909 -0,41914 0,002472 0,081203 biocarta_opposing_roles_of_aif_in_apoptosis_and 0,027813 0,017365 0,019108 0,246402 0,259977 0,248602 0,655175 0,681736 0,581776 -0,03294 -0,16302 -0,36222 0,210812 0,002706 0,166177 -0,81443 -0,6909 -0,41914 0,002472 0,081203 biocarta_oxidative_stress_induced_gene_express -0,15522 -0,23077 -0,17394 -0,11341 0,363098 0,127923 -0,46478 -0,38875 -0,64716 -1,14625 -0,9596 -0,11931 0,155118 0,155991 -0,00482 -0,87244 -0,14973 -0,37875 0,00273 0,081203 biocarta_role_of_erk5_in_neuronal_survival_Path -0,01449 -0,08556 -0,13897 0,048024 0,94702 0,672373 -1,0873 -1,10501 -1,53173 -1,30853 0,168758 -0,40224 0,38502 0,297202 0,6071 -2,12578 -0,86895 -0,57903 0,002175 0,081203 biocarta_sumoylation_by_ranbp2_regulates_tran 0,035442 -0,28842 -0,13322 0,677021 1,041997 0,570794 -0,06135 -0,01817 -0,62608 -1,22272 -1,39426 -1,54973 -0,07555 0,447467 0,473143 -4,20285 -2,87355 -1,9393 0,001978 0,081203 IL-10_Pathway_Stability_Determination -0,08594 -0,16094 -0,12462 -0,4609 -1,08781 -0,68747 -0,81754 -0,72131 -0,65877 0,488173 0,161437 0,453507 -0,43928 -0,66856 -0,4821 -0,51929 -0,5369 -0,16268 0,002717 0,081203 KEGG_Asthma_Main_Pathway -0,92536 0,984838 0,750134 -1,18581 1,304749 -0,46151 0,345053 -0,32538 3,118863 3,544877 2,944382 3,417157 -1,93547 -1,0916 -2,48962 7,38825 7,646953 6,278714 0,002015 0,081203 KEGG_Chemical_carcinogenesis_Main_Pathway -0,48611 0,482025 0,299496 -6,00179 -5,6727 -6,50256 2,258246 1,697655 4,608719 -0,48462 -0,4126 2,434626 0,352365 -1,16738 -4,35911 7,398341 7,438082 2,374476 0,002529 0,081203 KEGG_Glycosphingolipid_biosynthesis_ganglio_se -0,05158 -0,05223 -0,14588 0,215666 -0,00895 0,587639 -2,72306 -2,56964 -2,90637 -0,55121 -0,17887 0,123933 0,366303 0,419149 1,00047 -1,58553 -1,44862 -0,65406 0,002659 0,081203 melatonin_degradation_I -0,33032 -0,08964 -0,05181 -1,08487 0,091712 -0,75844 0,254946 0,003498 0,430858 0,472514 0,076249 1,13783 -0,72573 -0,34017 -0,28765 1,456982 1,215032 0,606843 0,002737 0,081203 methylglyoxal_degradation_I 0,006641 -0,17513 -0,0566 -0,1148 0,110834 -0,02071 0,213296 0,266281 0,16545 -0,37605 -0,10676 -0,28853 0,058353 0,262846 0,192927 -0,6134 -0,2716 -0,39179 0,001865 0,081203 NCI_Coregulation_of_Androgen_receptor_activity -0,0603 -0,09422 -0,04527 0,11928 -0,21246 0,482637 -0,45888 -0,54222 -0,61212 -1,11735 -0,94561 -0,42526 0,149743 0,239523 0,375721 -1,78485 -1,57482 -1,10153 0,00193 0,081203 NCI_Endogenous_TLR_signaling_Pathway_(regula 0,114439 0,007704 -0,06281 -0,99746 -0,79636 -0,76134 -1,23833 -1,10726 -1,00608 0,260702 0,679227 0,309124 -0,22037 -0,87356 -0,02113 2,251522 1,854248 2,245762 0,001917 0,081203 NCI_Endogenous_TLR_signaling_Pathway_(regula 0,114439 0,007704 -0,06281 -0,99746 -0,79636 -0,76134 -1,23833 -1,10726 -1,00608 0,260702 0,679227 0,309124 -0,22037 -0,87356 -0,02113 2,251522 1,854248 2,245762 0,001917 0,081203 NCI_Ephrin_B_reverse_signaling_Main_Pathway -0,11314 -0,04325 -0,21819 0,15293 1,494103 0,370099 -1,58519 -1,55369 -1,71124 -1,42465 -0,90702 -0,81251 0,444975 0,571204 0,834972 -0,0421 -0,19591 0,22203 0,001994 0,081203 NCI_IL5_mediated_signaling_events_Pathway_(re -0,14444 -0,32328 -0,04696 -0,33492 0,008625 -0,40112 0,364576 0,425323 0,454352 0,870177 0,295824 0,133588 -0,69628 -0,671 -0,43069 0,248487 0,666583 0,243117 0,001872 0,081203 NCI_Neurotrophic_factor_mediated_Trk_recepto -0,11487 -0,32096 -0,40676 -0,36682 -0,23133 0,022017 -4,09989 -3,99654 -4,51468 -1,22128 -0,61758 -1,62644 0,351863 0,507784 0,022883 -1,42663 -0,7119 -1,79564 0,001797 0,081203 NCI_Nongenotropic_Androgen_signaling_Pathway 0,029913 -0,07291 -0,14468 0,426688 -0,00662 0,243142 -0,14317 -0,05238 -0,35013 -1,14497 -0,85622 -1,11174 0,257842 0,238061 0,407285 -2,36945 -2,53801 -1,5065 0,002633 0,081203 NCI_PAR1_mediated_thrombin_signaling_events_ -0,03368 -0,17067 -0,12251 0,290093 -0,07593 0,055936 -0,64874 -0,46627 -1,07919 -1,94782 -0,52942 -1,53765 0,527148 0,602407 0,769191 -3,04092 -1,4976 -0,76503 0,002609 0,081203 NCI_Signaling_events_mediated_by_TCPTP_Main 0,127507 -0,12052 -0,08541 0,846363 -0,48473 0,026656 -1,84365 -1,64226 -2,44069 -3,3171 -1,66148 -1,32179 0,115219 1,598488 0,614203 -3,52936 -3,53357 -2,15069 0,002712 0,081203 NCI_Signaling_events_regulated_by_Ret_tyrosine -0,05739 0,153727 0,101735 -0,45755 -0,217 -0,00901 -1,6678 -1,88141 -1,46243 0,680061 -0,28615 0,869617 -0,11541 -0,33628 -0,37381 0,959401 0,434355 0,51162 0,002128 0,081203 NCI_Signaling_events_regulated_by_Ret_tyrosine -0,05739 0,153727 0,101735 -0,45755 -0,217 -0,00901 -1,6678 -1,88141 -1,46243 0,680061 -0,28615 0,869617 -0,11541 -0,33628 -0,37381 0,959401 0,434355 0,51162 0,002128 0,081203 NCI_Sumoylation_by_RanBP2_regulates_transcrip 0,049241 -0,32325 -0,18699 0,97898 1,149275 0,721621 -0,69292 -0,50709 -1,06695 -1,55076 -1,7143 -1,60274 -0,08816 0,666769 0,642648 -5,00405 -3,17105 -2,00091 0,001749 0,081203 NGF_Pathway_Actin_Polymerization_Neurite_Ou 0,042626 -0,14272 -0,23564 0,323126 0,486401 0,243973 -0,01568 0,03754 -0,21091 -0,43728 -0,88855 -0,26278 -0,08017 0,289952 0,008113 -1,26316 -0,934 -0,04972 0,002251 0,081203 Notch_Signaling_Pathway_Gene_Expression_Chro 0,137521 0,108204 0,071085 0,566124 1,531634 0,724284 1,214535 1,564542 1,322961 0,169469 0,072171 0,094197 0,697746 0,355062 0,60213 -1,00937 -1,75603 -1,35828 0,002711 0,081203 Notch_Signaling_Pathway_Transcription_of_Targe 0,137521 0,108204 0,071085 0,566124 1,531634 0,724284 1,214535 1,564542 1,322961 0,169469 0,072171 0,094197 0,697746 0,355062 0,60213 -1,00937 -1,75603 -1,35828 0,002711 0,081203 reactome_Activation_of_NOXA_and_translocation -0,02983 -0,11984 -0,10647 0,317031 0,324093 -0,15977 0,742677 0,735594 0,66342 -0,12817 0,01802 -0,3941 0,332458 0,066539 0,293166 -0,24113 -0,45857 -0,49227 0,002404 0,081203 reactome_Activation_of_PUMA_and_translocatio -0,02983 -0,11984 -0,10647 0,317031 0,324093 -0,15977 0,742677 0,735594 0,66342 -0,12817 0,01802 -0,3941 0,332458 0,066539 0,293166 -0,24113 -0,45857 -0,49227 0,002404 0,081203 reactome_CaMK_IV_mediated_phosphorylation_ 0,034595 -0,06736 -0,04585 0,226603 0,111048 0,269397 0,057308 0,051778 -0,08965 -1,11886 -0,45917 -0,4845 0,026748 -0,08834 -0,00401 -0,86819 -0,64394 -0,5757 0,002399 0,081203 reactome_G0_and_Early_G1_Main_Pathway 0,192187 -0,15086 -0,161 1,18653 1,433092 0,06572 2,838384 3,141435 2,116802 -1,70443 -0,77511 -2,02123 0,127465 0,415291 0,485978 -4,25404 -3,45457 -2,58284 0,002237 0,081203 reactome_Metabolism_of_Angiotensinogen_to_A -0,50788 -0,00558 -0,24366 -1,52273 -1,47465 -0,06621 0,228588 -0,05919 1,25462 2,226922 1,260365 1,881896 -0,19178 -0,40264 -0,0223 2,881621 2,515343 2,231536 0,002228 0,081203 reactome_Multifunctional_anion_exchangers_Ma -0,01461 -0,18217 -0,07586 -1,51667 -0,41282 -1,43484 -0,76649 -0,42688 -0,68511 3,252192 0,621878 0,780823 -0,7738 -0,52552 -0,8069 0,624024 1,03096 0,155606 0,001767 0,081203 reactome_PLC_beta_mediated_events_Main_Pat 0,282639 -0,14341 -0,13262 0,984622 1,842214 0,459844 0,007973 0,136243 -0,15701 -0,05965 0,637425 -0,31582 0,796171 0,706077 0,884993 -0,52617 -0,67273 0,35075 0,001801 0,081203 Regulation_of_Cytoskeleton_Remodeling_by_Act 0,040356 0,15441 -0,17124 0,408972 0,728413 0,693667 -1,30805 -0,68508 -2,19859 -2,97383 -1,26011 -2,76706 0,27257 0,417598 0,486318 -3,39871 -2,20052 -0,989 0,002221 0,081203 NCI_Class_I_PI3K_signaling_events_mediated_by_ 0,124782 0,074642 0,041454 0,776814 1,106506 0,220771 -1,38919 -1,20283 -1,88045 -0,69173 -0,43629 -0,13272 0,119288 0,337412 0,303082 -1,76055 -0,78325 -0,47648 0,002829 0,081308 NCI_p75_NTR_mediated_signaling_Pathway_(cell 0,034375 -0,10632 -0,01919 1,511664 0,771288 0,712369 -1,14214 -1,0956 -1,34372 -0,50793 0,452991 -0,55369 0,298692 0,157085 0,259083 -1,68948 -1,11554 -1,02811 0,002897 0,081308 reactome_Interleukin_2_signaling_Main_Pathway -0,21031 0,22216 0,160367 -1,23468 0,09779 -1,42831 0,222791 -0,37618 0,460624 1,822389 0,752917 1,282398 -0,18683 -0,68945 -0,27337 0,871486 0,295853 0,396085 0,002841 0,081308 reactome_NGF_processing_Main_Pathway -0,16621 -0,23912 -0,01481 -0,5779 -0,3693 -0,41932 -0,68978 -0,86825 -0,63888 1,045006 0,225021 0,850902 -0,17669 -0,04446 -0,00725 0,938266 0,71957 0,702815 0,002795 0,081308 reactome_Plasmalogen_biosynthesis_Main_Pathw 0,164855 -0,04833 -0,01841 0,499465 0,403955 0,516314 -1,23467 -1,05925 -1,51991 -0,66487 -0,20651 -0,835 0,028041 0,215781 0,10157 -1,82289 -1,20858 -0,84132 0,002872 0,081308 reactome_SOS_mediated_signalling_Main_Pathw -0,06919 -0,16539 -0,15149 0,228839 0,110631 -0,21716 -0,53992 -0,57281 -0,77118 -0,47192 -0,19554 -1,23045 -0,07708 0,28139 0,140775 -1,17578 -0,90892 -1,00482 0,002851 0,081308 NCI_Plasma_membrane_estrogen_receptor_signa 0,03981 -0,23077 -0,24939 0,409578 1,407064 0,888186 -0,40935 -0,45065 -0,56691 -1,12626 -0,33571 -1,09283 -0,10393 0,076133 -0,08964 -2,59999 -2,34693 -1,37253 0,002951 0,081346 NCI_Plasma_membrane_estrogen_receptor_signa 0,03981 -0,23077 -0,24939 0,409578 1,407064 0,888186 -0,40935 -0,45065 -0,56691 -1,12626 -0,33571 -1,09283 -0,10393 0,076133 -0,08964 -2,59999 -2,34693 -1,37253 0,002951 0,081346 NCI_S1P1_Main_Pathway -0,02005 -0,23685 -0,1077 0,906732 0,655889 0,419407 -0,43731 -0,24164 -0,36069 0,238526 -0,35961 -1,64299 -0,08613 0,216708 0,327804 -1,93713 -1,37266 -0,8148 0,003078 0,084115 reactome_Linoleic_acid_LA_metabolism_Main_Pa 0,021355 -0,04786 -0,04559 -0,65337 -0,36228 -0,61139 0,252845 0,228589 0,000738 1,597947 0,960794 0,835714 -0,59897 -0,53073 -0,52997 -0,56841 0,147337 0,344944 0,003127 0,084714 reactome_Transport_of_organic_anions_Main_Pa -0,11214 0,486867 0,434901 0,171633 -0,56148 -1,83683 -0,52541 -0,49783 0,065711 1,740421 0,341735 -0,28032 -0,61879 -0,57438 -1,64367 1,787401 1,802567 0,108966 0,003165 0,084979 reactome_Role_of_second_messengers_in_netrin -0,10521 -0,23628 -0,16588 0,021297 -0,46634 -0,01575 -1,44021 -1,31418 -1,20117 -1,6255 -1,72624 -2,65059 0,253259 -0,11507 -0,01865 -2,27169 -1,76511 -2,48605 0,003256 0,086683 NCI_p38_MAPK_signaling_Main_Pathway 0,114179 -0,07954 -0,07828 1,084542 0,935193 0,296963 -0,6394 -0,26754 -1,26681 -1,66386 -0,51446 -1,19279 -0,05149 0,007869 -0,28334 -2,01846 -1,97821 -1,34132 0,0033 0,087119 NCI_Netrin_mediated_signaling_events_Pathway_ -0,30656 -0,41224 -0,27616 -0,75256 0,079465 -0,30833 -2,051 -1,98966 -2,09781 -1,54093 -0,79714 -0,97457 0,360789 0,151922 0,091557 -1,5204 -1,13836 -1,13353 0,003358 0,087895 NCI_LKB1_signaling_events_Pathway_(Pathway_p 0,04113 -0,11998 -0,09654 0,636191 0,476933 -0,03471 -0,43211 -0,31267 -0,53211 -3,05836 -0,79641 -1,20277 0,289718 0,482856 0,155393 -2,46602 -2,52965 -0,96668 0,003488 0,090319 NCI_PAR1_mediated_thrombin_signaling_events_ -0,28754 -0,76407 -0,55811 0,531613 0,985669 0,085147 -3,87892 -3,52971 -4,02982 -2,39648 0,025107 -1,65994 0,279277 0,45231 1,483285 -2,14571 -0,48487 0,823022 0,003619 0,090319 reactome_ABC_family_proteins_mediated_transp -0,1613 0,341882 0,294281 -0,27249 -0,11147 -0,73757 0,714656 0,566819 1,194844 2,342973 1,293563 1,091951 0,442688 0,192458 -0,29343 3,290766 2,034527 2,54984 0,003616 0,090319 reactome_Kinesins_Main_Pathway 0,185416 -0,24208 -0,29476 1,160384 0,596642 -0,11045 0,39491 0,74351 -0,46499 -2,33285 -4,45338 -4,01363 -0,46757 -0,01901 0,203391 -4,70447 -3,16549 -1,8175 0,003624 0,090319 reactome_LRR_FLII_interacting_protein_1_LRRFIP 0,048853 -0,05635 -0,0684 -0,08546 0,239798 0,185501 -0,8095 -0,77691 -0,96842 -0,94568 -0,11804 -0,58652 0,208702 0,232896 0,358744 -0,28392 -0,20882 -0,05254 0,00355 0,090319 Tight_Junctions -0,45676 -0,05959 -0,22023 -0,54037 -2,44549 -2,34767 -3,83851 -4,43529 -2,84513 0,788183 -0,06026 -0,51839 -0,47189 -0,92495 -0,96088 1,735229 1,400901 1,480309 0,003533 0,090319 IL-2_Pathway_IL2_Gene_Expression_via_POLR1E_ -1,08591 -1,09458 -1,28446 -1,26131 0,088638 -1,46782 -4,62712 -3,89585 -5,79559 -1,49094 -2,22933 -3,16697 0,937787 0,373534 1,148767 -6,20952 -6,56523 -4,87056 0,003829 0,091047 reactome_Constitutive_Signaling_by_NOTCH1_HD 0,208887 0,089149 0,038767 0,296627 0,686674 0,434293 -0,11942 -0,06169 -0,15097 -1,5664 0,518935 -0,71481 1,005318 0,680146 0,813169 -2,58177 -1,85462 -1,1592 0,003749 0,091047 reactome_Formation_of_Senescence_Associated_ 0,25044 -0,19168 -0,17694 0,305297 0,23937 0,153014 -1,39011 -1,12626 -1,53082 -1,64258 -0,56005 0,011679 0,559631 -0,14721 0,659699 -1,48435 -1,01963 -0,63108 0,003785 0,091047 reactome_Miscellaneous_substrates_Main_Pathw 0,017428 0,353627 0,556065 -0,08406 -0,07702 -0,56761 -0,67705 -0,87782 0,385096 1,198278 0,016849 0,865471 0,357676 -0,13954 0,206959 1,492806 1,682114 1,050923 0,003813 0,091047 reactome_Thyroxine_biosynthesis_Main_Pathway -0,02683 0,144091 -0,02859 -1,03104 0,117469 -0,06248 -0,08533 -0,15443 0,573787 0,520208 0,395925 0,333536 -0,60201 -0,38138 -0,13007 1,252365 1,807767 1,242716 0,00374 0,091047 reactome_VEGF_ligand_receptor_interactions_M -0,13926 -0,00881 -0,0362 0,066174 0,375263 -0,01318 -0,26704 -0,46124 -0,19967 0,012583 -1,24582 -0,6436 0,209331 0,365398 0,229644 -0,22071 -0,36741 -0,39529 0,003703 0,091047 NCI_LPA_receptor_mediated_events_Pathway_(s -0,10951 0,079899 -0,00981 -0,03315 -0,04512 -0,67212 -0,18503 -0,28834 -0,08706 0,838569 0,540999 0,245306 -0,34488 -0,8891 -0,67678 -0,28011 0,378436 0,519508 0,00393 0,092747 NCI_GMCSF_mediated_signaling_events_Main_Pa -0,08814 -0,10661 -0,01249 -0,41792 -0,19793 -0,16701 0,228259 0,22667 0,243142 0,62259 -0,08379 0,373506 -0,09974 -0,37169 -0,18296 0,081252 0,044137 0,048959 0,004143 0,092975 NCI_IL2_signaling_events_mediated_by_STAT5_M -0,08814 -0,10661 -0,01249 -0,41792 -0,19793 -0,16701 0,228259 0,22667 0,243142 0,62259 -0,08379 0,373506 -0,09974 -0,37169 -0,18296 0,081252 0,044137 0,048959 0,004143 0,092975 NCI_IL2_signaling_events_mediated_by_STAT5_P -0,08814 -0,10661 -0,01249 -0,41792 -0,19793 -0,16701 0,228259 0,22667 0,243142 0,62259 -0,08379 0,373506 -0,09974 -0,37169 -0,18296 0,081252 0,044137 0,048959 0,004143 0,092975 NCI_IL2_signaling_events_mediated_by_STAT5_P -0,08814 -0,10661 -0,01249 -0,41792 -0,19793 -0,16701 0,228259 0,22667 0,243142 0,62259 -0,08379 0,373506 -0,09974 -0,37169 -0,18296 0,081252 0,044137 0,048959 0,004143 0,092975 reactome_FMO_oxidizes_nucleophiles_Main_Pat -0,04646 0,16072 0,175666 -0,55705 -1,07223 -0,33686 0,070366 0,022251 0,125835 1,009552 0,329642 -0,82811 -0,34366 -0,60742 -0,42534 0,14832 0,066744 0,040707 0,004026 0,092975 reactome_Transport_of_Mature_mRNA_Derived_ 0,490446 -0,00903 0,080245 2,179989 2,397256 1,487998 2,119921 3,004093 0,385801 -3,34421 -3,3053 -3,29252 0,575909 -0,03505 0,38018 -10,4717 -7,14652 -5,73848 0,004179 0,092975 reactome_Transport_of_Ribonucleoproteins_into 0,324778 -0,15474 0,058049 2,355741 2,174812 1,482774 1,60423 2,29254 0,104237 -4,28068 -2,35064 -2,12757 0,053592 0,124026 0,310148 -9,36847 -6,75906 -5,15377 0,004157 0,092975 sphingosine_and_sphingosine-1-phosphate_meta 0,051428 -0,03852 0,34413 -0,77395 -1,4062 -0,9134 -0,4752 -0,58782 -0,60528 1,771181 0,439893 0,336867 -0,22632 0,109721 -0,12432 0,605361 0,226244 1,102068 0,004036 0,092975 reactome_DSCAM_interactions_Main_Pathway 0,144341 -0,34217 -0,18591 0,300706 0,167991 0,043606 -0,63227 -0,50028 -0,8642 -1,32348 -0,87269 -2,2196 0,402938 0,166501 0,25003 -0,60345 -0,52016 -0,37295 0,004256 0,094029 biocarta_role_of_mef2d_in_t_cell_apoptosis_Mai 0,516815 0,157868 -0,0491 0,155656 0,407384 0,336715 0,414888 1,113465 -0,50472 -1,33395 -1,47793 -0,67512 0,059042 0,707609 0,336744 -2,39536 -1,82522 -1,95926 0,004426 0,094596 NCI_Glucocorticoid_receptor_regulatory_network -0,03704 -0,31682 -0,24697 0,598805 0,89566 0,908903 -0,29445 -0,382 -0,47378 -0,28131 -0,19225 0,013492 -0,3082 0,444586 0,353552 -2,52176 -1,74886 -1,31697 0,004507 0,094596 NCI_Glucocorticoid_receptor_regulatory_network -0,03704 -0,31682 -0,24697 0,598805 0,89566 0,908903 -0,29445 -0,382 -0,47378 -0,28131 -0,19225 0,013492 -0,3082 0,444586 0,353552 -2,52176 -1,74886 -1,31697 0,004507 0,094596 NCI_Glucocorticoid_receptor_regulatory_network -0,03704 -0,31682 -0,24697 0,598805 0,89566 0,908903 -0,29445 -0,382 -0,47378 -0,28131 -0,19225 0,013492 -0,3082 0,444586 0,353552 -2,52176 -1,74886 -1,31697 0,004507 0,094596 NCI_HIF_1_alpha_transcription_factor_network_M -0,10807 -0,175 -0,25129 -0,03782 0,023566 0,3025 -0,63148 -0,5289 -0,9656 -0,35288 -0,47869 -1,05672 0,194947 0,482171 0,288967 -2,61395 -1,44488 -1,16972 0,004449 0,094596 reactome_NEP_NS2_Interacts_with_the_Cellular_ 0,357428 -0,11582 0,094112 2,034069 2,035807 1,38902 1,609345 2,371502 0,164926 -4,33712 -2,83032 -2,73396 -0,10621 0,02481 0,217382 -9,53054 -6,75931 -5,08554 0,004378 0,094596 reactome_Regulation_of_Glucokinase_by_Glucok 0,201387 -0,2758 -0,01022 1,65132 1,8253 1,235129 1,688319 2,105725 0,417305 -3,59928 -2,28377 -2,09025 -0,21869 -0,3149 0,243426 -8,12196 -5,63879 -4,47365 0,004528 0,094596 reactome_Scavenging_of_heme_from_plasma_M -0,23702 0,564066 -0,08002 -0,54336 -0,10406 0,185482 0,091028 -0,47946 1,041319 2,036783 1,976368 2,067233 0,423617 0,246351 -0,07253 2,618769 1,596414 2,695202 0,004359 0,094596 spermidine_biosynthesis 0,128669 -0,04937 -0,05696 0,388103 -0,05463 0,315111 -0,15191 -0,33632 -0,33774 -0,37013 -0,12475 -0,06803 0,434467 0,135008 0,133983 -0,59469 -0,09674 -0,01395 0,004555 0,094596 reactome_Transcriptional_regulation_of_white_a 0,057783 -0,35339 -0,24365 -1,10426 0,252386 -0,16563 -1,03228 0,525359 -2,86052 -2,15163 -4,26476 -3,73671 1,420176 0,837294 2,39213 -9,1637 -6,33213 -5,27591 0,004588 0,094637 biocarta_mapkinase_signaling_Main_Pathway 0,15214 -0,49961 -0,50227 -0,49057 -0,34076 -0,24517 -2,83486 -2,0932 -5,04139 -5,45509 -1,05352 -1,69712 1,922634 1,390108 2,343973 -5,15072 -2,94417 -2,00084 0,004736 0,095054 KEGG_Base_excision_repair_Main_Pathway 0,329281 0,068826 0,02713 -0,24994 1,127527 1,523839 3,276761 3,205608 2,094358 -4,47274 -0,71899 -2,054 0,371882 0,690497 0,833234 -5,75229 -4,66845 -2,94386 0,004878 0,095054 NCI_Class_I_PI3K_signaling_events_mediated_by_ 0,086403 -0,04604 -0,09364 0,281468 1,218478 0,217666 -1,40161 -1,29057 -1,97267 -1,05161 -0,05747 0,463119 0,552525 0,712717 0,602111 -2,39242 -1,18843 -0,64496 0,004829 0,095054 NCI_PAR1_mediated_thrombin_signaling_events_ -0,09951 -0,26593 -0,20777 -0,09937 -0,01415 -0,18369 -0,84644 -0,64785 -1,20292 -1,90953 -0,48334 -1,35542 0,310586 0,547092 0,519359 -3,0816 -1,55866 -0,81713 0,004824 0,095054 NCI_PLK1_signaling_events_Pathway_(spindle_sta 0,18571 -0,02813 0,124284 0,139469 -0,02635 0,007185 1,669825 1,835299 1,093846 -1,27052 -1,48674 -1,6017 -0,00744 0,330194 0,145408 -2,01232 -1,67395 -1,14926 0,004806 0,095054 reactome_Adherens_junctions_interactions_Main -0,5524 -0,09794 -0,00472 0,137396 0,169693 -1,3007 -1,88874 -2,09796 -1,46515 1,906433 0,866096 2,503772 -1,22192 -0,4142 -0,24151 2,048107 2,178479 0,874538 0,004871 0,095054 reactome_Attachment_of_GPI_anchor_to_uPAR_ -0,07794 -0,10751 -0,19547 -0,0721 0,971666 0,024763 0,072112 0,202164 -0,17536 -1,99824 0,055405 -0,81987 0,048293 0,3402 0,370832 -1,63216 -0,60837 -0,97512 0,004711 0,095054 reactome_Nuclear_Pore_Complex_NPC_Disassem 0,38447 -0,11808 0,021443 2,194075 2,402817 1,82337 0,701465 1,567839 -0,83611 -2,89059 -2,89662 -2,81126 -0,4103 -0,2046 0,179398 -9,30201 -7,05057 -5,44757 0,00478 0,095054 reactome_Recycling_of_bile_acids_and_salts_Ma -0,39844 0,51143 0,361644 -1,2493 -0,51499 -0,80277 0,84153 0,69967 1,581011 2,737803 -0,76917 -0,39082 -0,4035 -0,85866 -1,38967 2,070843 2,843971 0,976419 0,004882 0,095054 biocarta_toll_like_receptor_Pathway_(Pathway_p 0,178805 0,021698 -0,03059 0,543159 0,034792 0,068476 -0,26047 0,040941 -0,49276 0,026016 -0,16382 -0,83672 0,270438 0,192011 0,215946 -0,46243 -0,47325 -0,22804 0,005008 0,0951 JAK-STAT_Pathway_Gene_Expression_via_MYC 0,03087 -0,12358 -0,04009 0,223182 0,903241 0,610157 0,51851 0,630217 0,387103 -0,42112 0,030341 -0,45533 -0,07591 0,11302 0,261507 -1,21189 -0,55419 -0,28237 0,005029 0,0951 KEGG_Hematopoietic_cell_lineage_Main_Pathwa -1,1086 0,040489 0,602951 -0,42635 -2,03481 0,414509 -4,83681 -7,21508 0,563654 10,38103 1,611251 4,646752 -1,23867 -1,99177 -3,45328 11,46969 5,610588 4,720999 0,004943 0,0951 reactome_Lysosphingolipid_and_LPA_receptors_M -0,34443 -0,31834 -0,09553 -0,2951 -0,3529 -0,17476 -0,03783 -0,22168 0,799437 0,310898 0,54334 1,250453 -0,16893 -1,29833 -0,47817 1,306917 1,954756 1,091384 0,004995 0,0951 reactome_NOSTRIN_mediated_eNOS_trafficking_ -0,18101 -0,19608 -0,1271 -0,7889 -0,38788 -0,27306 -1,3252 -1,35346 -1,41331 -0,18015 0,032938 0,078715 -0,38028 -0,32964 -0,68008 0,167487 -0,49596 0,112019 0,005037 0,0951 NCI_S1P3_Pathway_(Sinus_Bradycardia) 0,030714 -0,2095 -0,15502 0,607412 0,19122 0,678142 -0,0742 -0,09584 -0,14028 -0,07037 0,056787 -0,34286 0,213752 0,003448 0,342211 -1,56683 -1,7576 -1,10071 0,005115 0,095985 biocarta_deregulation_of_cdk5_in_alzheimers_dis -0,07859 -0,06435 -0,00595 0,868257 0,262168 0,847853 0,112227 0,244696 0,138115 -0,20997 -0,03135 -0,51982 0,189812 0,239974 0,282114 -0,27365 0,226516 -0,07718 0,005296 0,095987 biocarta_deregulation_of_cdk5_in_alzheimers_dis -0,07859 -0,06435 -0,00595 0,868257 0,262168 0,847853 0,112227 0,244696 0,138115 -0,20997 -0,03135 -0,51982 0,189812 0,239974 0,282114 -0,27365 0,226516 -0,07718 0,005296 0,095987 folate_polyglutamylation 0,073292 0,01128 -0,05645 -0,0763 0,446297 -0,28675 -0,04876 0,002001 -0,08448 -0,74946 -0,26734 -0,67669 0,227193 0,134056 0,391404 -0,82501 -0,60342 -0,6797 0,005192 0,095987 NCI_PLK1_signaling_events_Pathway_(cytokinesis 0,130756 0,007083 0,062405 0,223424 -0,25314 0,068334 1,230545 1,483512 0,781478 -1,02899 -1,09172 -1,46318 0,026512 0,325603 0,21573 -2,06105 -1,83567 -1,11828 0,005348 0,095987 reactome_Erythrocytes_take_up_carbon_dioxide_ -0,0874 0,208032 0,120002 -0,96361 -0,25502 -0,52759 0,284059 -0,24415 0,860653 0,597152 1,221352 1,930668 0,204114 0,250087 0,408401 2,106673 1,592503 2,253565 0,005362 0,095987 reactome_Erythrocytes_take_up_oxygen_and_re -0,0874 0,208032 0,120002 -0,96361 -0,25502 -0,52759 0,284059 -0,24415 0,860653 0,597152 1,221352 1,930668 0,204114 0,250087 0,408401 2,106673 1,592503 2,253565 0,005362 0,095987 reactome_G2_Phase_Main_Pathway -0,08932 -0,26048 -0,10224 -0,16628 0,159573 -0,703 0,390348 0,552102 0,401655 -1,85906 -1,72072 -1,77526 0,243851 0,265056 0,021071 -1,02565 -1,13714 -0,82597 0,005332 0,095987 TGF-Beta_Pathway -3,21271 -2,15567 -0,08388 -10,1033 -5,07797 -7,18603 -7,28975 -10,0646 -3,33012 7,993852 1,42469 2,679687 0,218988 -1,95174 -1,28255 7,376712 7,706526 8,720771 0,005208 0,095987 NCI_amb2_Integrin_signaling_Pathway_(positive_ -0,00687 -0,23085 -0,1408 0,593109 -0,14595 0,023577 -1,02663 -1,12979 -0,65482 -1,58094 -0,22141 -0,48169 0,501445 0,23052 0,54208 -0,16653 -0,54748 -0,09254 0,005418 0,0961 reactome_Transport_of_the_SLBP_independent_ 0,430141 -0,04215 0,041511 2,043889 2,03221 1,163618 1,868945 2,658302 0,32675 -3,42126 -2,73476 -2,88551 0,357971 -0,38361 0,101035 -9,63286 -6,58762 -5,22115 0,00543 0,0961 ATM_Pathway_Repair_and_Recombination 0,042693 -0,00306 -0,04541 0,017551 0,507643 0,492437 0,229529 0,355623 -0,06456 -0,08199 -0,54418 -0,46827 -0,03087 0,177098 0,1065 -0,60731 -0,16759 -0,10793 0,005614 0,0972 KEGG_Taurine_and_hypotaurine_metabolism_Ma 0,144846 0,119804 0,093169 -1,16202 -0,60012 -0,50087 -0,80241 -0,84586 -0,24654 0,550045 1,142322 0,048227 -0,2305 -0,03084 0,301438 1,310169 0,577037 0,861565 0,005571 0,0972 NCI_IL2_mediated_signaling_events_Pathway_(T_ -0,13716 0,408967 0,314045 -1,36494 0,073322 -1,40191 -0,31468 -0,76729 -0,12825 0,702533 0,398184 0,248033 -0,09202 -0,39198 -0,20332 1,384106 0,894274 0,989351 0,005582 0,0972 reactome_NOTCH2_intracellular_domain_regulat 0,078362 -0,08362 -0,05056 -0,15978 0,221072 -0,20914 -0,48565 -0,37465 -0,63742 -1,11971 -0,9357 -0,90779 0,427041 -0,09054 0,182531 -2,22974 -1,33507 -1,38157 0,005617 0,0972 biocarta_polyadenylation_of_mrna_Main_Pathwa 0,230794 0,058398 0,012254 0,600653 0,621984 0,446425 0,4685 0,642127 -0,03087 -0,67451 -0,49559 -0,13562 0,021085 0,428214 0,371337 -2,30722 -1,77636 -0,84072 0,005861 0,09738 GPCR_Pathway_Gene_Expression_via_JUN_NFKB 0,021399 -0,87946 -0,23106 -0,91108 2,262803 0,120907 -6,29871 -4,46163 -7,81377 -3,59442 -0,53321 -1,34012 1,090731 1,043209 2,793744 -6,46412 -6,39922 -1,35781 0,005789 0,09738 KEGG_Endocytosis_Main_Pathway -0,03054 -0,33468 -0,47162 0,076349 -0,82955 -0,18696 -1,7828 -1,46874 -2,23091 -1,29742 -1,62199 -1,35772 0,861697 0,923972 0,803004 -5,01682 -3,95663 -3,38812 0,005895 0,09738 KEGG_Fat_digestion_and_absorption_Main_Path -0,06141 0,166883 -0,03364 -0,5471 -0,60565 -0,00666 0,128447 -0,15713 0,188104 0,336931 0,241847 0,624643 0,160361 -0,36849 -0,09056 0,713779 0,55108 0,190244 0,005908 0,09738 NCI_Validated_nuclear_estrogen_receptor_alpha_ -0,3862 -0,2944 -0,41817 0,213621 0,072796 0,080886 1,092785 1,067373 0,57523 -2,48534 -0,42221 -1,77213 0,91801 0,347862 1,162283 -6,46279 -4,66157 -3,97173 0,005854 0,09738 reactome_Amino_acid_and_oligopeptide_SLC_tra -0,12255 0,33196 -0,00216 -0,66875 -0,39602 -0,98403 0,321828 0,04225 0,182234 0,686967 0,606658 -0,12707 -0,06541 -0,22539 0,100331 1,922927 1,825114 2,26736 0,005779 0,09738 reactome_Regulation_of_KIT_signaling_Main_Pat -0,36288 -0,30148 -0,19516 0,475922 0,270247 -0,01955 -1,62963 -1,89753 -1,97324 -2,54334 -0,25431 -0,30071 -0,17731 -0,0246 0,295392 -1,30201 -1,86081 -1,07237 0,005862 0,09738 reactome_Synthesis_of_IPs_in_the_nucleus_Main 0,005333 -0,1967 -0,11284 0,016281 0,37743 -0,17443 -0,82058 -0,73619 -1,20989 0,035132 -1,05847 -0,78776 0,100164 0,099447 0,047782 -1,10018 -1,49514 -1,18466 0,005724 0,09738 reactome_Transport_of_inorganic_cations_anion -0,12255 0,33196 -0,00216 -0,66875 -0,39602 -0,98403 0,321828 0,04225 0,182234 0,686967 0,606658 -0,12707 -0,06541 -0,22539 0,100331 1,922927 1,825114 2,26736 0,005779 0,09738 NCI_Coregulation_of_Androgen_receptor_activity -0,12645 -0,11874 -0,09545 -0,06794 -0,50934 0,567272 -0,36308 -0,54381 -0,67174 -1,63956 -0,50803 -0,69676 0,190798 0,412224 0,476644 -2,61629 -2,5853 -1,6137 0,005997 0,097807 reactome_G_alpha_12_13_signalling_events_Mai -0,09958 -0,9166 -0,71203 1,989534 2,694947 0,63687 -4,06944 -4,44415 -5,0175 -7,46635 -0,0014 -0,60206 0,054082 1,26693 0,343622 -7,84511 -4,99978 -2,14301 0,005973 0,097807 KEGG_Pathogenic_Escherichia_coli_infection_Ma -0,28428 -0,6319 -0,29528 0,692331 0,28552 -0,04111 -1,92879 -2,30242 -1,91968 -2,67296 -2,38937 -1,09437 -0,4785 -0,81742 -0,39245 -4,70468 -3,52368 -3,19108 0,006083 0,098694 reactome_Fatty_acids_Main_Pathway 0,310177 0,583648 0,722699 1,480539 0,304362 0,628488 -1,29072 -1,38687 0,506399 2,505423 2,047135 2,33728 -0,58579 0,04558 -0,60101 3,683586 2,38941 1,672429 0,006169 0,09886 reactome_Nuclear_import_of_Rev_protein_Main 0,39482 -0,12323 0,076102 1,951038 1,714121 1,614219 2,067484 2,781065 0,539372 -3,95498 -2,45203 -1,80008 0,093772 0,117398 0,61558 -10,159 -6,93391 -5,49036 0,00615 0,09886 reactome_PCP_CE_Main_Pathway -0,69508 -0,51323 -0,22858 0,453358 0,896581 -0,23808 1,139601 1,211839 1,711997 -4,28327 -0,85907 -1,97332 0,683539 0,787818 0,061674 -0,7957 -0,34562 -0,56969 0,006189 0,09886 NCI_Neurotrophic_factor_mediated_Trk_recepto 0,138472 -0,70691 -0,69386 -0,80868 -0,89551 0,067767 -7,23781 -7,07829 -8,57017 -4,46474 -2,71159 -3,35134 0,085157 0,257959 0,581344 -7,89142 -4,6749 -4,27351 0,006393 0,09916 NCI_Validated_nuclear_estrogen_receptor_beta_ -0,05888 -0,30978 -0,15332 0,012134 0,452261 0,08665 -0,90513 -1,08815 -1,035 -0,86855 -0,00272 -0,81625 0,780145 0,472803 0,634472 -3,59636 -2,40658 -2,53355 0,006354 0,09916 reactome_Rev_mediated_nuclear_export_of_HIV 0,427435 -0,05745 0,08486 2,147413 1,665066 1,617491 1,618489 2,461306 0,180258 -4,16698 -2,79315 -2,13829 -0,12674 0,031199 0,254493 -10,2969 -6,81652 -5,16619 0,006358 0,09916 reactome_Termination_of_O_glycan_biosynthesis -0,48375 0,51592 0,324225 -0,29686 -0,35648 0,295538 0,950961 -0,34392 1,686616 3,340558 1,008034 0,381338 -0,79144 -0,52343 -0,96667 4,534635 4,079936 3,95286 0,006313 0,09916 reactome_Transport_of_the_SLBP_Dependant_M 0,434969 -0,066 0,030105 2,014849 2,02032 1,19371 2,005039 2,770742 0,445045 -3,31598 -2,70699 -2,87576 0,374299 -0,38489 0,031008 -10,1664 -7,1018 -5,61692 0,006398 0,09916 reactome_Vpr_mediated_nuclear_import_of_PIC 0,192383 -0,31407 -0,03434 1,805007 2,040093 0,969867 1,384036 2,158988 -0,06077 -3,64747 -2,17155 -2,59151 -0,12679 -0,16625 0,101942 -9,72757 -7,39906 -5,63708 0,006277 0,09916 reactome_Histidine_catabolism_Main_Pathway -0,01125 -0,10131 0,073656 -0,56762 -0,08685 0,071222 -0,13989 -0,32595 0,137836 1,162992 -0,00175 0,485964 0,01502 -0,26375 -0,20953 1,275376 0,882077 0,66423 0,006439 0,099293 reactome_TGF_beta_receptor_signaling_activates -0,11114 -0,1674 -0,28416 0,220282 -0,10927 0,051424 -0,80663 -0,83289 -1,17437 -1,28336 -0,2668 -0,35424 0,041621 0,1802 -0,19824 -1,60979 -1,35282 -0,63631 0,006517 0,100004 Glucocorticoid_Receptor_Signaling_Pathway 2,150534 -0,44882 -0,59244 4,716058 3,742243 4,224541 5,33951 8,497734 0,343709 -10,8979 -1,59856 -2,40433 0,525157 1,58176 3,637146 -22,0783 -18,0892 -14,2953 0,006925 0,102768 IL-2_Pathway_Apoptosis_Inhibition -0,35465 -0,30087 -0,2512 0,281281 0,592189 0,295588 -0,15124 0,355057 -0,31867 0,100931 -0,90509 0,80358 0,294412 0,496006 0,822055 -2,11164 -1,4353 -0,55813 0,006899 0,102768 KEGG_Cell_cycle_Main_Pathway -0,79408 -0,32781 -0,49789 -1,49098 -0,56583 -1,71469 -9,15923 -9,54893 -7,3149 6,720622 5,865034 7,768711 0,5678 -0,30811 0,742164 8,808532 6,060961 3,263116 0,006806 0,102768 KEGG_Glycosphingolipid_biosynthesis_lacto_and_ 0,282899 -0,5024 -0,42233 2,757659 1,803323 2,484517 -1,85844 -1,87535 -2,09321 0,356948 -0,3069 -0,57764 1,1176 0,371676 0,198557 -1,07608 -1,19057 0,216445 0,006892 0,102768 NCI_Endogenous_TLR_signaling_Pathway_(respira -0,18041 -0,16465 -0,15475 -0,46039 -0,56785 -0,28175 -1,20636 -1,27114 -1,1619 1,932419 0,859575 1,235605 -0,95463 -0,8396 -0,46183 -0,11579 0,282499 -0,37639 0,006863 0,102768 reactome_Activation_of_DNA_fragmentation_fac 0,173223 -0,24193 -0,11838 0,514235 0,876514 0,78974 0,228174 0,438624 -0,00169 -0,93862 0,182976 0,585453 0,480648 0,009787 0,486525 -2,08535 -0,9403 -0,73263 0,00699 0,102768 reactome_Pre_NOTCH_Processing_in_the_Endop -0,05471 -0,07489 -0,00345 0,538556 0,112636 0,106883 0,431556 0,496095 0,158526 -0,01789 -0,20725 -0,00367 0,320305 0,132914 0,331698 -1,04813 -1,29307 -0,29844 0,006994 0,102768 reactome_Synthesis_secretion_and_inactivation_ 0,056529 0,259257 -0,02399 -0,1981 0,517954 1,000629 -1,48117 -1,63007 -1,80393 -0,19705 -0,11847 0,583634 0,933056 1,243278 0,870821 -1,38559 -1,13791 -0,12543 0,006891 0,102768 reactome_Transport_of_Mature_mRNA_derived_ 0,910998 -0,00369 0,192462 2,823239 2,038272 1,351689 2,938813 4,102156 1,028218 -5,38329 -4,57505 -4,54985 0,825803 0,026246 0,475149 -15,3554 -12,2176 -9,62745 0,006958 0,102768 Ephrin-B_Pathway -0,98651 -1,39566 -1,2429 2,092422 0,611486 0,376646 -6,33758 -6,70345 -6,60382 -6,94776 -1,37912 -0,33522 0,279957 -0,15775 1,079217 -11,7192 -9,0455 -5,07937 0,007113 0,104017 NCI_Signaling_events_mediated_by_TCPTP_Pathw 0,188932 0,005837 0,024253 0,148964 -0,49847 0,091544 -0,58929 -0,34637 -1,11796 -2,07039 -0,61134 -0,81282 0,413645 0,798779 0,432589 -2,27193 -2,26286 -1,20478 0,007166 0,104311 biocarta_ceramide_signaling_Pathway_(Pathway_ 0,215957 -0,18053 0,074708 -0,38236 -0,53307 -1,17182 -1,77974 -1,64585 -1,72666 0,451418 -0,23338 0,069964 -0,57604 -0,12529 -0,57392 -0,02264 0,028459 -0,287 0,007315 0,104749 KEGG_Alzheimer_s_disease_Main_Pathway -0,09347 -0,1221 -0,14687 0,123658 -0,23686 0,417974 -0,11891 0,108317 -0,11352 -0,38176 -0,06125 -0,25974 0,404032 0,39939 0,516198 -0,27586 -0,10309 -0,38741 0,007319 0,104749 NCI_EPHA_forward_signaling_Main_Pathway -0,37589 -0,13629 -0,29753 -1,072 -1,47225 -1,5741 -1,94089 -2,45112 -1,88565 0,468236 0,891024 0,612408 -0,71724 -0,08635 0,349539 0,785941 1,649305 1,350117 0,007331 0,104749 reactome_Displacement_of_DNA_glycosylase_by_ -0,10542 0,013628 -0,02175 0,692047 0,466498 0,42791 0,107971 -0,06117 0,204648 -0,27123 -0,17799 -0,15767 0,194245 0,03609 -0,12225 -1,68885 -1,05787 -0,51469 0,007323 0,104749 biocarta_integrin_signaling_Main_Pathway -0,20831 -0,34396 -0,50645 0,851252 1,065516 -0,38582 -2,61911 -2,20781 -2,85453 -0,66528 1,614696 -0,51399 1,820473 0,790194 1,529893 -1,20406 -0,99226 -0,72217 0,007626 0,106524 Cell_Migration_Adhesion_and_Angiogenesis_driv -0,00279 -0,07892 -0,02533 0,231901 0,576243 0,203638 -0,19466 -0,15771 -0,53815 -0,23874 0,011361 -0,37596 -0,00792 0,011748 0,011437 -0,70723 -0,39612 -0,1837 0,007542 0,106524 reactome_cell_division_Main_Pathway -0,01974 -0,1067 -0,06669 0,152148 -0,24601 -0,08624 0,619456 0,6866 0,353108 -0,34529 -0,99596 -0,68835 0,00722 0,04854 0,120613 -1,51791 -1,36319 -0,92848 0,007604 0,106524 reactome_Platelet_Adhesion_to_exposed_collage -0,10331 0,069862 0,02442 -0,55317 -0,51504 -0,2814 -0,33839 -0,57428 0,347722 -0,0338 0,232227 -0,40714 -0,11976 -0,35363 -0,08515 0,782774 0,06669 0,486878 0,007622 0,106524 reactome_U12_Dependent_Splicing_Main_Pathw 0,983231 0,16757 0,086789 2,332564 1,815558 2,679301 1,79898 2,870693 -0,04288 -6,38505 -3,70927 -3,4053 0,192147 -0,34868 0,53838 -14,2772 -11,457 -9,70218 0,007561 0,106524 biocarta_mechanism_of_protein_import_into_the 0,060584 -0,11737 -0,04717 0,045731 -0,31066 0,237994 0,199595 0,332202 -0,02914 -1,66119 -0,86031 -0,12486 0,523995 0,632204 0,809256 -3,2433 -1,6587 -1,06581 0,008079 0,107555 dolichol_and_dolichyl_phosphate_biosynthesis -0,1198 -0,14954 -0,12643 -0,26674 0,177569 -0,00913 0,049719 0,089632 -0,06786 -0,20904 -0,62243 -0,33731 -0,10966 0,011947 0,246543 -0,26555 -0,43503 -0,49919 0,008149 0,107555 KEGG_Caffeine_metabolism_Main_Pathway -0,05251 0,088169 0,197325 -0,3654 0,207714 0,072272 0,244441 -0,08891 0,177248 1,709793 0,440294 0,757601 -0,51003 -0,59056 -0,39074 0,655457 0,262271 -0,01539 0,007821 0,107555 mTOR_Pathway_Metabolism_Stress_Response_a -0,01572 -0,15891 -0,06657 -0,04972 0,757553 0,274366 -0,34762 -0,36161 -0,46524 -0,59738 -0,24016 -0,70845 0,419578 0,301531 0,487081 0,004049 0,152381 0,409781 0,008014 0,107555 NCI_Arf6_downstream_Pathway_(cortical_actin_c 0,079701 -0,00012 -0,03363 0,167213 -0,26248 0,090284 -0,78249 -0,78034 -0,96781 -0,31003 -0,38932 -0,40414 0,201666 0,093962 -0,00617 -0,50031 -0,41752 -0,42261 0,008143 0,107555 NCI_Arf6_downstream_Pathway_(lamellipodium_ 0,079701 -0,00012 -0,03363 0,167213 -0,26248 0,090284 -0,78249 -0,78034 -0,96781 -0,31003 -0,38932 -0,40414 0,201666 0,093962 -0,00617 -0,50031 -0,41752 -0,42261 0,008143 0,107555 NCI_Signaling_events_mediated_by_HDAC_Class_ 0,006264 -0,19807 -0,16777 1,320413 0,251344 0,319348 -0,71588 -0,56077 -1,29865 -0,1346 -2,24727 -0,73915 -0,13873 0,380897 0,542106 -4,42859 -3,48121 -1,91 0,007825 0,107555 reactome_Activation_of_BIM_and_translocation_ 0,069963 -0,04349 -0,01536 -0,02168 0,093568 0,377232 0,456269 0,622211 0,221012 -0,43107 -0,01488 -0,24664 0,048459 0,052857 0,149007 -0,95554 -0,80201 -0,45887 0,007915 0,107555 reactome_E2F_mediated_regulation_of_DNA_rep -0,03833 -0,0926 -0,07684 -0,01587 0,332568 -0,26394 0,66201 0,657314 0,622613 -0,43705 -0,16272 -0,46538 0,122782 -0,04107 0,093038 -0,42057 -0,59128 -0,48932 0,007888 0,107555 reactome_G1_S_Specific_Transcription_Main_Pat -0,03833 -0,0926 -0,07684 -0,01587 0,332568 -0,26394 0,66201 0,657314 0,622613 -0,43705 -0,16272 -0,46538 0,122782 -0,04107 0,093038 -0,42057 -0,59128 -0,48932 0,007888 0,107555 STAT3_Pathway_G1_to_S_Cell_Cycle_Progression -0,05936 -0,09802 -0,11764 0,43123 0,058728 -0,13633 -0,14747 -0,16128 -0,25146 0,366063 -0,44856 -0,36128 0,190855 0,178606 0,248486 -1,02623 -0,76472 -0,7802 0,008055 0,107555 threonine_degradation 0,082251 0,015268 0,038428 0,158859 0,529653 -0,27552 -0,21295 -0,11682 -0,42967 -0,18365 -0,19825 -1,52893 0,132197 0,543905 0,740366 -2,13629 -1,96195 -1,30543 0,007955 0,107555 TNF_Signaling_Pathway_Gene_Expression_and_C -0,02321 -0,17612 -0,25574 -0,4306 -0,9983 -0,31896 -1,89369 -1,18476 -2,81495 -0,88753 -2,39404 -2,62822 0,797798 0,605341 0,975541 -3,54164 -2,96388 -1,65761 0,008055 0,107555 2-deoxy-alpha-D-ribose_1-phosphate_degradation -0,0311 -0,06056 -0,09551 -0,08033 -0,24202 0,180834 -0,17648 -0,3371 -0,03572 -1,20272 -0,3177 -0,66501 0,121718 0,173741 0,119255 -0,30002 -0,54522 -0,32115 0,009369 0,107614 adenine_and_adenosine_salvage_II 0,064849 0,024979 0,025587 0,216034 0,323673 0,17127 0,081691 0,134164 -0,03481 -0,12249 0,162168 0,030705 0,046615 0,101259 0,167342 -0,56831 -0,37403 -0,37708 0,008437 0,107614 biocarta_alk_in_cardiac_myocytes_Main_Pathway -0,34088 -0,25234 -0,11889 -0,31794 -0,13526 -0,35553 -0,4537 -0,23444 -0,79698 -1,3197 -0,872 -1,00235 2,206649 2,149313 2,078248 -2,71724 -2,21416 -1,55033 0,009487 0,107614 biocarta_cycling_of_ran_in_nucleocytoplasmic_tr 0,053941 -0,09505 -0,02954 0,248452 0,111926 0,418324 -0,24175 -0,06471 -0,36995 -0,34322 -0,68529 0,133277 0,250178 0,414416 0,443616 -2,27807 -0,95218 -0,61685 0,009426 0,107614 biocarta_hop_pathway_in_cardiac_development_ -0,14471 0,005499 -0,03926 -0,30809 -0,04292 -0,25137 -0,25415 -0,46415 -0,10287 0,44302 0,178429 0,433734 0,261102 -0,20162 -0,10713 0,426672 0,732436 0,783277 0,009636 0,107614 biocarta_hop_pathway_in_cardiac_development_ -0,14471 0,005499 -0,03926 -0,30809 -0,04292 -0,25137 -0,25415 -0,46415 -0,10287 0,44302 0,178429 0,433734 0,261102 -0,20162 -0,10713 0,426672 0,732436 0,783277 0,009636 0,107614 biocarta_hop_pathway_in_cardiac_development_ -0,14471 0,005499 -0,03926 -0,30809 -0,04292 -0,25137 -0,25415 -0,46415 -0,10287 0,44302 0,178429 0,433734 0,261102 -0,20162 -0,10713 0,426672 0,732436 0,783277 0,009636 0,107614 biocarta_il_4_signaling_Pathway_(G1_phase_of_m0,019905 0,365587 0,18809 -0,74824 -0,15038 0,071738 -0,36836 -0,43367 0,167212 1,436913 1,047042 1,361308 0,302457 -0,38915 -0,16587 -0,05293 0,802718 0,097457 0,008272 0,107614 biocarta_mets_affect_on_macrophage_differentia 0,039715 0,007236 -0,02413 0,567701 0,574135 0,547768 -0,01391 0,011957 -0,13006 -0,03784 -0,18325 -0,19427 -0,01285 0,092211 0,002962 -0,49526 -0,44518 -0,21756 0,009387 0,107614 diphthamide_biosynthesis 0,04742 -0,04263 -0,02206 0,2936 0,243687 0,226057 0,236526 0,389275 -0,02033 -0,18837 -0,259 -0,04869 0,025722 0,090951 0,107471 -1,24848 -1,07906 -1,04528 0,009635 0,107614 dTMP_ide_novoi_biosynthesis_mitochondrial 0,026449 0,011495 0,031039 0,414073 0,312421 0,291067 0,528803 0,52303 0,475544 -0,19657 0,115847 -0,13391 0,160868 0,093338 0,084135 0,018489 0,090659 0,150225 0,009671 0,107614 eicosapentaenoate_biosynthesis 0,264528 0,25125 0,127366 -1,44841 0,311702 -1,43409 0,93264 0,768783 0,697554 1,117983 0,549573 1,050009 -0,24644 -0,41531 -0,54982 -0,10262 0,113253 0,746601 0,009723 0,107614 Erythropoietin_Pathway_Anti-Apoptosis 0,085006 0,025381 0,097538 0,480436 0,734788 0,03216 -1,11466 -1,32419 -1,08615 -2,15604 -0,08068 -0,64451 0,869866 0,067406 0,085099 -1,98035 -0,76332 -0,45871 0,008342 0,107614 fatty_acid_activation -0,00672 0,045611 0,14759 -0,37984 0,104341 -0,24463 0,395564 0,297717 0,242083 0,963321 0,279055 0,485837 0,205577 0,014187 -0,07623 0,197754 0,782985 0,549518 0,008266 0,107614 Glucocorticoid_Receptor_Signaling_Pathway_Hist -0,03329 -0,05165 -0,04158 -0,02958 0,12792 0,055209 -0,53125 -0,53998 -0,69812 -0,41257 -0,28084 -0,30571 -0,1032 -0,08578 -0,05851 -0,84194 -0,51605 -0,38184 0,009278 0,107614 ILK_Signaling_Pathway_Tumor_Angiogenesis -0,10001 -0,0489 -0,06487 -0,10652 0,002766 0,00606 -0,26387 -0,34718 -0,31065 0,22607 -0,6362 -0,39105 0,230999 0,236495 0,287247 -0,21155 -0,48585 -0,69061 0,008592 0,107614 KEGG_ABC_transporters_Main_Pathway -0,28561 0,084039 0,402088 -1,49852 0,079059 -0,62856 -0,30256 -0,40577 0,207189 3,223924 0,034486 1,637661 0,23392 0,222038 -0,72017 5,153429 3,512079 3,603788 0,008671 0,107614 KEGG_Fatty_acid_elongation_Main_Pathway 0,046608 -0,05252 -0,03377 -0,05323 0,256211 0,07967 0,01182 0,105241 -0,11905 -0,0237 -0,34292 -0,01992 0,189657 -0,00503 0,188833 -0,79285 -0,70333 -0,58204 0,008893 0,107614 KEGG_Phenylalanine_metabolism_Main_Pathway -0,28562 0,171187 0,073344 -0,47486 -0,90177 -0,72992 -1,73122 -2,27944 -0,79816 -0,26452 -0,39231 1,021461 -0,25079 -0,52393 -0,56353 2,706749 1,950341 1,716522 0,008516 0,107614 KEGG_Purine_metabolism_Main_Pathway 0,576859 -0,02903 -0,36178 0,84339 -1,09429 -1,00386 0,870264 2,387264 -2,93179 -7,78508 -5,263 -7,02926 2,67185 2,253051 3,493696 -20,2418 -19,2561 -17,0399 0,008328 0,107614 NCI_Aurora_B_signaling_Main_Pathway 0,469618 -0,12565 0,052225 0,805406 0,835509 1,341205 3,632505 3,847007 2,717743 -4,97778 -3,46247 -3,23141 -0,39648 -0,83039 -0,86532 -8,01654 -6,67294 -4,36848 0,008403 0,107614 NCI_Hedgehog_signaling_events_mediated_by_G -0,01794 -0,00982 -0,19392 0,3899 0,216927 -0,05568 0,702291 0,503727 0,399384 1,117376 0,44677 1,440743 -0,44617 -0,14951 -0,44311 1,273495 1,050172 1,093303 0,009638 0,107614 NCI_N_cadherin_signaling_events_Pathway_(adh 0,02114 -0,03067 -0,05961 0,584502 0,263842 0,153007 -0,0722 -0,01126 -0,20475 -0,04019 0,009251 -0,32936 0,016113 0,038722 0,017654 -0,47614 -0,26664 -0,40478 0,009863 0,107614 NCI_PLK1_signaling_events_Main_Pathway 0,612867 -0,06188 0,115313 1,093162 0,872179 -0,51027 5,3663 6,444287 3,504946 -5,81034 -5,87354 -6,53976 -0,98099 -0,20396 -0,46363 -11,7629 -7,32312 -5,42567 0,009648 0,107614 NCI_PLK1_signaling_events_Pathway_(Golgi_orga 0,20705 -0,06283 -0,02175 0,110435 0,042336 0,054141 2,395815 2,803206 1,791598 -1,93685 -1,83782 -1,95751 -0,38883 -0,06834 -0,35207 -2,55203 -1,92892 -1,28903 0,009515 0,107614 NCI_PLK1_signaling_events_Pathway_(metaphase 0,148834 0,009196 0,080593 0,080929 -0,27025 -0,04242 1,607203 1,789812 1,152761 -0,91059 -1,12437 -1,19387 -0,0525 0,202405 0,068462 -1,4916 -1,33167 -0,83677 0,009024 0,107614 NCI_PLK1_signaling_events_Pathway_(positive_re 0,169419 -0,0052 0,055559 0,174246 -0,1496 0,01191 1,538634 1,732055 1,021354 -0,88479 -1,08547 -1,16558 -0,05709 0,282031 0,097199 -2,10708 -1,77687 -1,08765 0,008239 0,107614 NCI_PLK1_signaling_events_Pathway_(regulation_ 0,20705 -0,06283 -0,02175 0,110435 0,042336 0,054141 2,395815 2,803206 1,791598 -1,93685 -1,83782 -1,95751 -0,38883 -0,06834 -0,35207 -2,55203 -1,92892 -1,28903 0,009515 0,107614 NCI_PLK1_signaling_events_Pathway_(spindle_as 0,231336 -0,07599 0,025851 0,035488 -0,06937 -0,08198 2,635639 3,015971 2,048619 -1,56488 -1,95168 -2,09911 -0,0682 -0,06356 -0,21093 -3,05872 -2,22882 -1,67854 0,009855 0,107614 NCI_PLK1_signaling_events_Pathway_(spindle_elo 0,20705 -0,06283 -0,02175 0,110435 0,042336 0,054141 2,395815 2,803206 1,791598 -1,93685 -1,83782 -1,95751 -0,38883 -0,06834 -0,35207 -2,55203 -1,92892 -1,28903 0,009515 0,107614 NCI_Sphingosine_1_phosphate_S1P_Main_Pathw -0,06937 -0,62781 -0,20192 1,027599 0,763186 1,081729 -0,56276 -0,55649 -0,29497 -1,94897 -0,01945 -1,31559 0,028218 -0,39625 0,03048 -1,01313 -0,18802 -0,2301 0,009384 0,107614 NCI_Stabilization_and_expansion_of_the_E_cadh 0,02114 -0,03067 -0,05961 0,584502 0,263842 0,153007 -0,0722 -0,01126 -0,20475 -0,04019 0,009251 -0,32936 0,016113 0,038722 0,017654 -0,47614 -0,26664 -0,40478 0,009863 0,107614 NCI_Syndecan_3_mediated_signaling_events_Pat 0,01726 0,008185 0,018636 0,127704 0,408336 0,156281 0,657481 0,590855 0,282111 -0,91074 0,046623 -1,07649 0,223369 0,345206 0,247956 -1,16135 0,133873 -0,36695 0,008451 0,107614 Notch_Signaling_Pathway_gamma_Secretase 0,113627 -0,01589 -0,01306 0,010365 0,422806 -0,01563 -0,383 -0,27257 -0,63176 -0,14554 0,067382 0,019898 0,522084 0,746379 0,653019 -1,44762 -0,25313 -0,75363 0,009311 0,107614 pyrimidine_deoxyribonucleosides_salvage -0,00646 0,010596 -0,03377 0,839857 0,64964 0,478011 0,588685 0,761877 0,671216 -0,67474 -0,40214 -0,80546 0,181638 0,019237 0,10402 0,135463 0,059425 0,123293 0,009625 0,107614 Ras_Pathway_Gene_Expression_Cell_Proliferation 0,97981 -0,62099 -0,09616 1,409499 1,029019 -0,21627 -2,62945 -1,12238 -4,76859 -6,0666 -1,7562 -2,04649 1,31399 1,141443 1,841284 -12,9758 -8,90082 -7,70351 0,008941 0,107614 reactome_Association_of_TriC_CCT_with_target_ 0,298082 -0,14092 0,136766 0,746444 0,82395 0,103498 -1,29051 -0,45686 -2,04758 -3,35733 -0,99605 -2,58509 0,066312 0,690031 0,619963 -8,04069 -4,466 -3,73325 0,009889 0,107614 reactome_Cyclin_A_Cdk2_associated_events_at_S 0,385059 -0,13649 -0,17855 0,948825 1,059985 -0,46095 0,133516 0,56139 -0,42781 -1,93029 -1,63013 -0,91098 0,16067 0,295799 -0,23029 -5,23107 -3,53348 -3,24894 0,009731 0,107614 reactome_E2F_enabled_inhibition_of_pre_replica 0,588814 0,096064 -0,0455 1,08032 0,769731 0,732311 0,717409 1,2469 -0,09938 -2,02936 -0,83714 -2,2853 -0,20359 0,153097 -0,3979 -4,22534 -2,8646 -1,31774 0,009915 0,107614 reactome_Elongation_arrest_and_recovery_Main 0,354236 -0,2417 -0,33973 0,950656 0,111812 0,242792 0,186612 0,728776 -0,73234 -3,30689 -1,80261 -1,21383 -0,28614 0,036548 0,417075 -6,59669 -5,27658 -3,74742 0,009824 0,107614 reactome_HIV_elongation_arrest_and_recovery_ 0,354236 -0,2417 -0,33973 0,950656 0,111812 0,242792 0,186612 0,728776 -0,73234 -3,30689 -1,80261 -1,21383 -0,28614 0,036548 0,417075 -6,59669 -5,27658 -3,74742 0,009824 0,107614 reactome_Organic_anion_transporters_Main_Pat -0,20688 -0,07153 0,0502 -0,19987 -0,07122 -0,14325 0,110554 -0,17492 0,285365 0,672234 0,454356 0,688079 -0,22996 0,160019 -0,14198 1,570713 0,792711 0,705015 0,009002 0,107614 reactome_Pausing_and_recovery_of_HIV_elongat 0,354236 -0,2417 -0,33973 0,950656 0,111812 0,242792 0,186612 0,728776 -0,73234 -3,30689 -1,80261 -1,21383 -0,28614 0,036548 0,417075 -6,59669 -5,27658 -3,74742 0,009824 0,107614 reactome_Polo_like_kinase_mediated_events_Ma -0,07718 -0,12352 -0,24174 0,636404 0,499747 0,202597 1,606907 2,07066 1,10368 -2,12873 -2,62738 -1,25893 -0,79778 -0,61949 -0,21916 -4,24885 -2,15101 -2,06965 0,009688 0,107614 reactome_Processing_of_Intronless_Pre_mRNAs_ 0,455305 0,055234 0,000565 1,081567 0,630544 1,180544 0,239085 0,55669 -0,47774 -1,43867 -0,83246 -0,95543 -0,00806 -0,02174 0,379132 -4,61881 -4,04142 -2,35483 0,009126 0,107614 reactome_Removal_of_the_Flap_Intermediate_fr 0,252134 0,027847 0,065368 0,160373 0,759691 0,776361 2,567337 2,93805 2,559623 -1,0036 -0,26157 -0,5505 -0,01694 -0,00185 -0,17055 -1,6015 -1,71598 -1,10767 0,009542 0,107614 reactome_Role_of_LAT2_NTAL_LAB_on_calcium_ 0,082338 0,022627 -0,14277 0,100814 -0,07539 0,048299 -0,86048 -0,93137 -1,29048 -1,2888 -1,00497 0,373415 0,601808 0,533311 0,549939 -2,67041 -1,9289 -1,56232 0,009264 0,107614 reactome_Signaling_by_NOTCH3_Main_Pathway 0,104381 0,02715 -0,04965 -0,01209 0,948188 0,449182 -0,61409 -0,52581 -0,72351 -0,01951 0,848377 0,22146 0,992779 1,108233 0,91636 -1,14852 -0,04093 -0,26971 0,008644 0,107614 reactome_snRNP_Assembly_Main_Pathway 1,299668 0,427383 0,28088 4,691047 3,605535 4,436679 1,990829 3,08403 -0,92955 -5,39383 -2,23523 -3,08316 -0,19405 -0,18704 0,105547 -16,2036 -13,1087 -10,3402 0,008878 0,107614 Role_of_Small_GTPases_in_G1-S_Transition -0,01977 -0,87932 -0,71823 -0,99769 1,125139 -0,12509 -2,30968 -1,73035 -3,72615 -3,30734 -0,6757 0,04088 1,023002 0,423479 0,824114 -6,03348 -4,05651 -2,77559 0,009631 0,107614 STAT3_Pathway_Growth_Arrest_and_Differentiat -0,70468 -0,01375 0,133965 -0,84527 -0,81959 -4,42017 -8,75159 -9,36588 -4,28118 11,36867 3,590713 2,130397 1,907408 -0,27581 -0,06328 10,69921 10,31023 7,824909 0,009773 0,107614 KEGG_Pyrimidine_metabolism_Main_Pathway 0,8552 0,040625 -0,59705 0,871252 1,717468 -1,66616 2,768879 4,411151 -0,44566 -7,43609 -7,55159 -6,93944 0,466564 0,857057 1,423587 -21,6484 -17,3121 -15,5255 0,009989 0,107666 KEGG_Ribosome_biogenesis_in_eukaryotes_Main 1,142677 -0,65822 -0,5205 3,725104 5,090237 2,476367 0,121148 1,408367 -3,95499 -7,22199 0,956531 -3,49152 1,121071 1,758065 2,079124 -22,0408 -17,2179 -14,9143 0,009973 0,107666 Regulation_of_Cytoskeleton_Remodeling_by_Pro -0,45335 -0,63488 -0,67338 2,131701 2,770415 0,606161 -3,50863 -3,44865 -4,55988 -5,55393 -0,1836 0,582979 -0,46821 0,565246 0,998597 -5,98196 -3,42716 -0,10198 0,010052 0,10797 NCI_Signaling_events_mediated_by_TCPTP_Pathw -0,08576 -0,22674 -0,18261 0,033039 -0,61785 -0,54937 -1,10374 -1,02796 -1,4094 -1,86906 -0,95788 -0,41944 0,710567 1,065072 0,764426 -2,33507 -2,40935 -1,01216 0,010152 0,108296 WNT_Pathway_Cell_Survival 0,00021 0,184683 0,074178 -0,34771 0,772603 -0,07713 -1,27716 -1,11763 -2,14083 -1,61328 -0,88688 -0,54558 1,628937 1,369534 1,227456 -1,39627 -0,66253 0,171966 0,010148 0,108296 biocarta_inhibition_of_matrix_metalloproteinases -0,14348 -0,03027 -0,04858 0,391546 0,27518 -0,21467 -0,76156 -0,65772 -0,78191 -1,19042 0,40045 -0,56691 0,221512 0,394302 0,262645 -0,51045 -0,48026 -0,15794 0,010983 0,109677 biocarta_inhibition_of_matrix_metalloproteinases -0,14348 -0,03027 -0,04858 0,391546 0,27518 -0,21467 -0,76156 -0,65772 -0,78191 -1,19042 0,40045 -0,56691 0,221512 0,394302 0,262645 -0,51045 -0,48026 -0,15794 0,010983 0,109677 biocarta_lissencephaly_gene_lis1_in_neuronal_m 0,029623 -0,05983 0,032277 0,329907 -0,28717 0,230896 -1,05757 -1,06388 -1,40948 0,096054 -0,01877 -0,14376 0,392067 0,707657 0,76089 -1,19432 -1,00015 -0,64682 0,010418 0,109677 biocarta_regulation_of_bad_phosphorylation_Ma 0,012339 -0,25715 -0,39183 0,384881 1,860818 1,244647 -2,91473 -2,88537 -3,22508 -0,38431 0,162164 -0,46508 -0,16118 -0,06278 0,070893 -2,95172 -3,02162 -2,62423 0,010824 0,109677 biocarta_role_of_ran_in_mitotic_spindle_regulati 0,14069 -0,00345 -0,05944 0,077515 -0,82657 0,599431 1,053529 1,269476 0,710973 -2,94443 -1,55177 -1,66484 0,032718 0,28952 0,305249 -3,62174 -1,81101 -1,04378 0,010874 0,109677 biocarta_the_co_stimulatory_signal_during_t_cel -0,33977 0,206284 0,025137 -0,61496 -0,74388 0,751749 0,500081 0,219926 1,104716 3,073517 -0,34585 0,940686 -0,92874 -0,61013 -0,72065 1,627099 1,744688 1,021913 0,010509 0,109677 biocarta_the_co_stimulatory_signal_during_t_cel -0,33977 0,206284 0,025137 -0,61496 -0,74388 0,751749 0,500081 0,219926 1,104716 3,073517 -0,34585 0,940686 -0,92874 -0,61013 -0,72065 1,627099 1,744688 1,021913 0,010509 0,109677 fatty_acid_biosynthesis_initiation 0,059921 -0,03397 -0,03296 -0,22938 0,098544 0,323505 0,131321 0,158175 -0,01587 -0,84042 0,017084 -0,75702 0,011973 0,005288 0,152585 -0,71354 -0,97739 -0,54901 0,010409 0,109677 NCI_IL27_mediated_signaling_events_Pathway_(c 0,012984 -0,12163 -0,04514 -0,53432 -0,21711 -0,54601 -0,42459 -0,42305 -0,57563 1,435751 0,731876 0,727491 -0,51456 0,102594 0,060895 -0,29149 0,4264 0,549103 0,011056 0,109677 NCI_IL27_mediated_signaling_events_Pathway_(M0,012984 -0,12163 -0,04514 -0,53432 -0,21711 -0,54601 -0,42459 -0,42305 -0,57563 1,435751 0,731876 0,727491 -0,51456 0,102594 0,060895 -0,29149 0,4264 0,549103 0,011056 0,109677 NCI_IL27_mediated_signaling_events_Pathway_(m0,012984 -0,12163 -0,04514 -0,53432 -0,21711 -0,54601 -0,42459 -0,42305 -0,57563 1,435751 0,731876 0,727491 -0,51456 0,102594 0,060895 -0,29149 0,4264 0,549103 0,011056 0,109677 NCI_IL27_mediated_signaling_events_Pathway_(p 0,012984 -0,12163 -0,04514 -0,53432 -0,21711 -0,54601 -0,42459 -0,42305 -0,57563 1,435751 0,731876 0,727491 -0,51456 0,102594 0,060895 -0,29149 0,4264 0,549103 0,011056 0,109677 NCI_IL27_mediated_signaling_events_Pathway_(T 0,012984 -0,12163 -0,04514 -0,53432 -0,21711 -0,54601 -0,42459 -0,42305 -0,57563 1,435751 0,731876 0,727491 -0,51456 0,102594 0,060895 -0,29149 0,4264 0,549103 0,011056 0,109677 NCI_IL27_mediated_signaling_events_Pathway_(T 0,012984 -0,12163 -0,04514 -0,53432 -0,21711 -0,54601 -0,42459 -0,42305 -0,57563 1,435751 0,731876 0,727491 -0,51456 0,102594 0,060895 -0,29149 0,4264 0,549103 0,011056 0,109677 NCI_IL27_mediated_signaling_events_Pathway_(T 0,012984 -0,12163 -0,04514 -0,53432 -0,21711 -0,54601 -0,42459 -0,42305 -0,57563 1,435751 0,731876 0,727491 -0,51456 0,102594 0,060895 -0,29149 0,4264 0,549103 0,011056 0,109677 NCI_PAR1_mediated_thrombin_signaling_events_ 0,013998 -0,01982 0,026777 0,284475 -0,48738 -0,06593 -0,69176 -0,60866 -0,87292 -1,48458 -0,79121 -1,14275 0,240137 -0,08923 0,19259 -1,62583 -0,96521 -0,54857 0,010564 0,109677 reactome_Cleavage_of_Growing_Transcript_in_th 0,96653 0,120858 0,177964 1,763779 0,487941 1,301026 1,741059 2,440904 0,679018 -3,18475 -2,48798 -2,75338 0,540758 0,445867 0,884248 -10,7086 -9,69414 -6,97032 0,01099 0,109677 reactome_mRNA_3_end_processing_Main_Pathw 0,96653 0,120858 0,177964 1,763779 0,487941 1,301026 1,741059 2,440904 0,679018 -3,18475 -2,48798 -2,75338 0,540758 0,445867 0,884248 -10,7086 -9,69414 -6,97032 0,01099 0,109677 reactome_mTOR_signalling_Main_Pathway 0,072772 0,016939 0,033611 0,212948 0,024749 0,062927 0,218504 0,276469 -0,01202 -0,4659 -0,11731 -0,02314 0,067464 0,104235 0,209511 -0,56784 -0,51659 -0,01638 0,011011 0,109677 reactome_Pausing_and_recovery_of_Tat_mediate 0,318486 -0,23163 -0,34865 1,076508 0,173073 0,248354 0,317492 0,824637 -0,51423 -3,16166 -1,39413 -0,91835 -0,3656 -0,00828 0,383445 -6,18596 -5,06896 -3,60966 0,011003 0,109677 reactome_Tat_mediated_HIV_elongation_arrest_ 0,318486 -0,23163 -0,34865 1,076508 0,173073 0,248354 0,317492 0,824637 -0,51423 -3,16166 -1,39413 -0,91835 -0,3656 -0,00828 0,383445 -6,18596 -5,06896 -3,60966 0,011003 0,109677 thyroid_hormone_metabolism_II_via_conjugation -0,10337 -0,00574 0,175506 -0,41935 -0,48307 -0,8607 0,430055 0,508188 0,71766 0,693882 0,952986 1,026469 -0,30815 -0,65116 -0,60806 -0,63792 -0,25481 -0,58666 0,010728 0,109677 NCI_PLK1_signaling_events_Pathway_(proteasom 0,106362 -0,08013 0,027002 -0,0043 -0,02841 -0,49906 1,888433 2,093129 1,424662 -1,30779 -1,32285 -1,56552 -0,19784 0,083288 -0,09691 -1,47411 -1,64645 -1,0627 0,011127 0,110036 reactome_Phosphate_bond_hydrolysis_by_NUDT 0,010831 -0,06827 -0,08702 0,158133 0,163638 0,232912 0,316189 0,258614 0,081951 -0,02323 -0,63383 -0,06005 -0,02775 0,080666 0,275952 -0,33312 -1,3949 -0,83179 0,011311 0,111496 iSi-methyl-5-thio-alpha-D-ribose_1-phosphate_de 0,021853 -0,0795 -0,11616 0,258714 -0,21706 0,078563 -0,57326 -0,28453 -0,75824 0,200794 -0,44702 -1,13594 0,308909 0,429514 0,255147 -2,22994 -1,61664 -1,54254 0,011489 0,112192 NCI_Ceramide_signaling_Pathway_(cell_survival) 0,018835 -0,32357 -0,20426 -1,01183 -0,8707 -1,30863 -1,08305 -1,19457 -0,98632 -0,68368 -0,34939 1,533667 -0,76533 -0,03461 -0,7032 0,127198 0,107376 -0,08544 0,01142 0,112192 reactome_pre_mRNA_splicing_Main_Pathway 2,689298 0,201724 0,233858 6,173484 2,703141 4,757503 5,040588 7,525929 0,903061 -11,4627 -9,95756 -8,0222 0,119875 0,74649 1,949224 -39,2152 -31,1352 -24,3315 0,011481 0,112192 biocarta_e2f1_destruction_Main_Pathway -0,02287 -0,32877 -0,15042 0,452673 1,253782 -0,59713 1,244329 1,382883 1,106027 -0,43571 -0,04478 -0,47236 0,18606 0,26733 0,267281 -1,75436 -1,79108 -1,37398 0,011542 0,112352 biocarta_il22_soluble_receptor_signaling_Main_P -0,08593 -0,14527 -0,13175 -0,31873 -0,28002 -0,38867 0,344827 0,39445 0,669215 1,533512 -0,23757 0,709611 -0,22429 -0,02974 0,004031 1,18726 1,206245 1,234506 0,011655 0,113104 gamma-linolenate_biosynthesis 0,150892 0,177895 0,184078 -0,88714 0,664263 -0,78566 0,861134 0,659702 0,871541 1,220584 0,372406 0,603893 0,221597 -0,2719 -0,54597 1,013804 0,899214 1,278504 0,011712 0,113297 biocarta_double_stranded_rna_induced_gene_ex 0,25199 0,083792 0,06813 0,498532 -0,03428 0,402966 0,015559 0,179828 -0,26697 -0,31623 -0,7743 -1,22221 -0,12771 -0,19648 0,19987 -1,68914 -1,49154 -1,12533 0,01197 0,1141 NCI_EPHA_forward_signaling_Pathway_(proteaso -0,26724 -0,00081 -0,1887 -1,87637 -1,84881 -2,15969 -1,59598 -2,02968 -1,53877 0,387703 0,211094 1,014253 -0,60528 0,015189 0,125641 0,650649 1,510705 1,03835 0,011978 0,1141 NCI_Role_of_Calcineurin_dependent_NFAT_signa -0,01904 -0,1004 -0,09619 0,489733 0,425322 0,183344 -0,25786 -0,2804 -0,27884 -0,28126 -0,02328 -0,28285 0,259287 -0,00456 0,189639 0,204191 0,274615 0,031566 0,011883 0,1141 reactome_FCERI_mediated_NF_kB_activation_Ma -0,01651 -0,21915 -0,28878 -1,08854 0,046401 0,02321 -1,5336 -1,41212 -2,39409 -1,26567 -1,3697 -1,13913 1,590445 0,666304 0,811189 -1,81121 -2,02466 -1,22389 0,011948 0,1141 reactome_Synthesis_of_Lipoxins_LX__Main_Path -0,0172 -0,14024 0,173012 -0,35865 -0,68401 -0,26988 -0,31788 -0,58482 -0,36806 1,239048 0,294167 0,031591 0,079153 -0,46114 0,258683 1,376353 1,279742 0,209247 0,011952 0,1141 arsenate_detoxification_I_glutaredoxin 0,03297 0,127774 0,094789 -0,7837 -0,48533 -0,57821 -0,4216 -0,5058 -0,47314 -0,05613 0,219963 0,330908 0,135296 0,069931 -0,03497 0,804633 0,542887 0,609805 0,012306 0,114266 biocarta_p38_mapk_signaling_Main_Pathway 0,304819 -0,09214 -0,39002 -1,27198 -1,0478 -0,0812 -0,73836 -0,23155 -1,55379 -3,17998 -2,16207 -1,94927 1,121305 0,906797 1,215449 -4,40566 -3,11187 -1,9668 0,012077 0,114266 biocarta_rna_polymerase_iii_transcription_Main_ -0,04059 -0,14082 -0,24028 0,177654 0,437381 0,111928 -0,37931 -0,18096 -0,72352 -0,48158 -0,15332 -0,02623 -0,05196 -0,00434 0,056996 -1,85489 -1,34991 -1,35872 0,012542 0,114266 biocarta_rna_polymerase_iii_transcription_Pathw -0,04059 -0,14082 -0,24028 0,177654 0,437381 0,111928 -0,37931 -0,18096 -0,72352 -0,48158 -0,15332 -0,02623 -0,05196 -0,00434 0,056996 -1,85489 -1,34991 -1,35872 0,012542 0,114266 EGF_Pathway_Cytoskeleton_Regulation -0,21933 -0,12294 -0,15489 -2,10501 -1,78869 -1,78868 -2,66933 -2,54439 -3,01748 1,123654 0,621522 0,713624 -0,90297 -0,17898 -0,352 -0,39757 -0,97284 -0,12547 0,012471 0,114266 estradiol_biosynthesis_II 0,053058 0,039003 0,030302 0,080161 -0,14865 -0,27392 -0,4631 -0,41926 -0,32887 0,046695 0,107742 -0,0185 -0,04984 -0,19306 -0,2717 0,568624 0,015917 0,027734 0,012403 0,114266 iNi-acetylglucosamine_degradation_II 0,092674 0,071035 -0,04387 -0,27441 0,434474 0,072248 -0,77095 -0,66777 -0,94086 -0,81751 -0,2002 0,030646 0,09528 0,407607 0,403787 -1,43039 -1,44912 -1,24525 0,012766 0,114266 KEGG_RNA_polymerase_Main_Pathway 0,214763 -0,31617 -0,61983 0,84403 -0,58934 -1,05716 -1,03187 -0,18305 -2,73477 -3,54 -2,24187 -2,59718 0,634251 0,745866 0,772018 -10,2518 -8,57408 -7,72549 0,012358 0,114266 KEGG_Tyrosine_metabolism_Main_Pathway -0,46213 0,127193 -0,04398 -1,81367 -2,26904 -2,5309 -3,12095 -3,23524 -1,59786 0,600302 -0,89304 -0,07024 -0,20415 0,014233 -0,40412 2,440457 2,197889 1,688943 0,012122 0,114266 NCI_ATM_Main_Pathway 0,271255 -0,21758 -0,35429 1,837255 2,716958 1,526586 1,963332 2,893046 0,358062 -0,8647 -0,52467 -0,94419 -0,61748 -0,13542 0,260216 -5,80759 -2,29112 -1,93995 0,012665 0,114266 NCI_Notch_signaling_Pathway_(skeletal_muscle_t -0,04792 -0,02998 -0,06871 0,762792 0,464434 0,375632 -1,44651 -1,3387 -1,42595 -0,10957 0,739428 0,663203 0,407714 0,408198 0,588074 -0,98651 -0,6457 -0,38031 0,012306 0,114266 NCI_Plasma_membrane_estrogen_receptor_signa 0,018699 -0,65933 -0,6053 -0,87844 1,761117 0,082511 -2,91535 -2,78581 -3,24203 -1,31096 -0,06533 -1,4736 0,16778 0,099325 0,447263 -4,92054 -4,73152 -2,80559 0,012571 0,114266 NCI_S1P1_Pathway_(negative_regulation_of_cAM 0,056278 -0,18235 -0,14105 0,012742 0,258123 0,401619 0,007031 0,148499 -0,12313 0,018232 0,043211 -0,57159 0,156628 0,08021 0,150532 -1,63459 -1,58129 -1,10062 0,012724 0,114266 NCI_S1P1_Pathway_(negative_regulation_of_T_ce 0,056278 -0,18235 -0,14105 0,012742 0,258123 0,401619 0,007031 0,148499 -0,12313 0,018232 0,043211 -0,57159 0,156628 0,08021 0,150532 -1,63459 -1,58129 -1,10062 0,012724 0,114266 NCI_S1P4_Pathway_(cell_migration) 0,164037 -0,14599 -0,09593 0,350823 0,035822 0,63532 -0,06627 0,045929 -0,14172 -0,39702 -0,03033 -0,14843 0,035322 0,196085 0,243419 -1,51811 -2,1202 -1,29448 0,012561 0,114266 NCI_S1P5_Pathway_(negative_regulation_of_cAM 0,085543 -0,09985 -0,08732 0,513253 0,103333 0,324822 -0,17717 -0,16436 -0,20324 -0,08491 0,025292 -0,31658 0,155447 -0,01922 0,182859 -1,31775 -1,64281 -0,97332 0,012211 0,114266 reactome_Activation_of_the_AP_1_family_of_tra 0,076066 -0,26951 -0,30447 -0,16786 -0,1443 -0,14831 -0,40858 -0,1069 -1,03865 -0,5828 0,022505 -0,2473 0,559492 0,423831 0,608146 -2,19886 -1,38749 -1,46248 0,012455 0,114266 reactome_Axonal_growth_stimulation_Main_Pat -0,13512 -0,08371 -0,02761 0,079397 0,385519 0,434832 -0,54884 -0,56749 -0,38057 0,03631 -0,20427 0,083489 0,265143 -0,16558 0,169445 -0,34855 -0,33969 -0,20913 0,012158 0,114266 reactome_CDC6_association_with_the_ORC_origi 0,543984 0,122047 0,047024 1,273672 1,17308 1,229503 0,881521 1,285208 0,170492 -1,12033 0,54452 -1,31621 -0,01229 0,31493 -0,10159 -3,15198 -2,19888 -0,77893 0,012731 0,114266 reactome_CREB_phosphorylation_through_the_a 0,012276 -0,09249 -0,29315 0,321925 0,079661 0,102794 -1,31853 -1,21133 -2,08014 -1,41766 0,710704 -0,88221 0,075117 0,15002 0,565955 -2,25898 -1,81736 -1,30538 0,012736 0,114266 STAT3_Pathway -4,04027 0,168779 0,75789 -7,00637 -0,18024 -9,26423 -11,5091 -15,3638 -2,27209 16,51624 0,406325 3,826103 -0,04721 -1,83427 -1,63959 27,54291 26,94116 20,66256 0,012081 0,114266 NCI_Notch_mediated_HES_HEY_network_Main_P -0,51877 -0,4646 -0,4039 -0,59646 -1,16861 -0,78083 -0,39041 -0,25349 -0,83379 -1,77284 -1,92154 -0,43201 1,401331 1,405035 1,395009 -4,21179 -3,85557 -2,62817 0,012813 0,114365 KEGG_RNA_transport_Main_Pathway 1,190681 -0,08217 0,156604 1,941598 3,196034 3,261963 2,3095 3,560917 -0,03003 -3,35138 -1,98127 -4,46883 0,305946 1,001261 1,214131 -18,7482 -16,1767 -12,9007 0,01286 0,114454 reactome_Na_Cl_dependent_neurotransmitter_t 0,07544 0,214946 0,254104 -0,54499 -0,31574 -0,53601 1,299012 0,708566 2,83842 1,808886 1,949578 -0,12164 0,091375 -0,23002 -0,646 6,304031 4,829373 4,257204 0,012944 0,114871 NCI_Reelin_signaling_Pathway_(long_term_memo -0,02941 0,184469 0,172218 -0,083 0,065209 -0,13576 -2,29717 -2,00532 -2,04824 0,767938 0,321136 -0,24557 -0,15123 -0,35331 0,069701 1,011989 1,341652 1,462039 0,013192 0,115463 NCI_Signaling_events_mediated_by_TCPTP_Pathw 0,168421 -0,03829 -0,06598 0,149203 -0,56537 -0,22384 -0,42806 -0,22881 -1,0422 -1,4541 -0,3447 -0,62955 0,57399 0,904091 0,572452 -2,98344 -2,62769 -1,6668 0,013196 0,115463 NCI_Signaling_events_mediated_by_TCPTP_Pathw 0,168421 -0,03829 -0,06598 0,149203 -0,56537 -0,22384 -0,42806 -0,22881 -1,0422 -1,4541 -0,3447 -0,62955 0,57399 0,904091 0,572452 -2,98344 -2,62769 -1,6668 0,013196 0,115463 reactome_G2_M_DNA_replication_checkpoint_M 0,110998 -0,01205 -0,00318 0,153163 0,446032 0,276832 0,954492 1,260915 0,730853 -1,77781 -1,65869 -1,01968 -0,3431 -0,347 -0,40764 -2,30414 -1,38475 -0,92403 0,013185 0,115463 reactome_Ketone_body_catabolism_Main_Pathw 0,060947 -0,04906 -0,02747 -0,0249 -0,03475 0,15925 -0,94808 -0,85676 -1,14898 -0,63282 -0,26092 0,163909 0,192192 0,063343 0,299356 -1,00815 -1,06126 -0,70467 0,013182 0,115463 NCI_BCR_signaling_Pathway_(actin_cytoskeleton_ -0,08774 0,075424 0,000289 -0,16944 -0,0506 -0,62003 -0,11203 -0,43757 -0,03725 0,18277 0,333196 -0,31166 -0,23593 -0,23013 -0,28866 0,458903 -0,27081 0,259289 0,013648 0,119087 biocarta_hypoxia_inducible_factor_in_the_cardiv 0,076446 -0,16487 -0,23945 -0,73946 0,190629 -0,01439 -0,58851 -0,36722 -1,08538 -0,69682 -0,16118 -1,25976 0,445561 0,462411 0,795387 -3,335 -2,0475 -1,85938 0,01384 0,119089 biocarta_transcription_regulation_by_methyltran -0,17719 -0,33809 -0,45349 -0,41003 0,721337 1,155902 -2,20193 -2,00209 -2,54864 -1,59726 -0,48455 -0,09046 -0,41191 -0,26884 0,255085 -3,64616 -2,40398 -1,86648 0,013691 0,119089 NCI_LPA_receptor_mediated_events_Pathway_(p -0,09681 0,076972 0,05044 0,411605 -0,19241 -0,16537 -0,00439 -0,11992 0,190223 0,647008 0,254961 0,807002 -0,25289 -0,74385 -0,58703 0,182268 0,590334 0,53708 0,013749 0,119089 NCI_Nongenotropic_Androgen_signaling_Pathway -0,11853 -0,28393 -0,30148 0,845114 0,553252 -0,48262 -0,56676 -0,26544 -0,9006 -1,70311 0,029664 -0,23889 0,17552 -0,11555 0,453569 -3,42829 -3,40903 -1,86794 0,013834 0,119089 reactome_TRAF3_dependent_IRF_activation_Mai 0,104879 -0,17621 -0,19675 0,284564 0,58122 0,466646 -0,95908 -0,90563 -1,27346 0,094915 -0,45613 -1,17401 0,319771 0,177169 0,616236 -0,11977 0,069858 0,691712 0,01382 0,119089 NCI_IL4_mediated_signaling_events_Main_Pathw -0,14598 0,147358 0,153959 -0,94885 -0,18696 -0,21113 -1,29845 -1,69587 -0,5316 1,413992 0,947168 0,575129 0,660695 -0,17751 0,265962 0,906818 1,715939 1,357538 0,01389 0,119192 NCI_HIF_2_alpha_transcription_factor_network_M -0,13883 -0,17148 -0,27203 -0,5324 -0,01383 -0,33721 -0,52657 -0,24888 -0,94256 -0,02141 -1,55269 -1,32411 0,634001 0,181242 0,684343 -3,63352 -2,3548 -1,46867 0,014011 0,119898 2-oxoisovalerate_decarboxylation_to_isobutanoy 0,093087 0,08663 0,063511 0,279854 0,612467 0,227401 0,073078 0,220325 -0,1158 0,057202 0,076366 -0,88319 0,019061 0,261326 0,510587 -2,09538 -1,97779 -1,48618 0,014191 0,120446 reactome_EPHB_mediated_forward_signaling_M 0,000152 -0,65727 -0,57051 1,201558 0,609408 0,153235 -4,66784 -4,13763 -5,61859 -2,87414 -0,0359 -0,37319 -0,13988 -0,00979 0,285977 -4,94152 -3,01827 -0,71073 0,014173 0,120446 triacylglycerol_degradation -0,33701 0,109903 0,056809 -0,17755 0,073878 0,303905 -1,7399 -1,92904 -1,51175 1,797158 1,130445 0,184225 -0,30613 -0,3866 0,111942 1,001184 1,193059 1,074761 0,014183 0,120446 NCI_ATM_Pathway_(G1_S_transition_checkpoint 0,116595 -0,28727 -0,32818 0,591518 1,771533 0,903289 1,616284 2,126956 0,373425 -0,59434 -0,68683 0,001398 -0,00031 -0,18652 -0,00875 -4,41678 -2,03681 -1,7103 0,014308 0,121113 ATM_Pathway_Cell_Survival 0,36893 -0,21109 -0,13326 1,139603 1,374421 0,820782 -0,54988 -0,02897 -0,96039 -0,23215 0,564696 -0,11175 0,187594 -0,22653 0,293839 -2,29726 -1,53947 -1,31769 0,014379 0,121386 biocarta_fas_signaling_pathway_cd95__Main_Pat 0,182262 0,135046 0,06881 -0,20834 0,293191 0,120221 0,563288 0,986593 0,326382 -0,66924 -1,04979 -1,10602 0,160885 0,248639 0,145809 -3,16026 -1,87726 -1,20755 0,016712 0,121401 biocarta_granzyme_a_mediated_apoptosis_Pathw 0,030353 0,164482 0,157429 0,235492 0,391795 -0,20609 0,224241 0,33765 0,244536 -0,7671 -0,35411 -0,34474 0,24536 0,220347 0,358042 -2,07551 -0,96067 -0,55578 0,0153 0,121401 biocarta_granzyme_a_mediated_apoptosis_Pathw 0,030353 0,164482 0,157429 0,235492 0,391795 -0,20609 0,224241 0,33765 0,244536 -0,7671 -0,35411 -0,34474 0,24536 0,220347 0,358042 -2,07551 -0,96067 -0,55578 0,0153 0,121401 biocarta_granzyme_a_mediated_apoptosis_Pathw 0,030353 0,164482 0,157429 0,235492 0,391795 -0,20609 0,224241 0,33765 0,244536 -0,7671 -0,35411 -0,34474 0,24536 0,220347 0,358042 -2,07551 -0,96067 -0,55578 0,0153 0,121401 biocarta_il_2_receptor_beta_chain_in_t_cell_acti 0,00449 -0,17422 -0,22729 0,700079 0,277798 0,05357 -0,41962 -0,29106 -0,62495 -0,21312 0,367789 -0,01446 -0,07812 0,096463 0,279234 -1,29747 -0,55573 -0,80479 0,017028 0,121401 biocarta_il_4_signaling_Pathway_(cell_survival) 0,056367 0,401077 0,262725 -0,70848 0,461131 0,325869 0,160483 0,141409 0,664166 1,390788 0,700279 1,146671 0,225186 -0,28922 -0,16519 0,492574 1,127164 0,231784 0,01685 0,121401 biocarta_regulation_of_transcriptional_activity_by 0,024025 -0,14557 -0,10572 0,574266 0,516253 0,244586 -0,34677 -0,01031 -0,3803 0,326339 -0,89068 -0,08688 0,110998 0,042134 -0,00921 -2,08522 -1,58684 -0,73009 0,015914 0,121401 biocarta_regulation_of_transcriptional_activity_by 0,024025 -0,14557 -0,10572 0,574266 0,516253 0,244586 -0,34677 -0,01031 -0,3803 0,326339 -0,89068 -0,08688 0,110998 0,042134 -0,00921 -2,08522 -1,58684 -0,73009 0,015914 0,121401 biocarta_sonic_hedgehog_receptor_ptc1_regulat 0,32248 -0,07674 -0,19408 0,147736 1,413506 0,103482 0,035594 0,578245 -0,2324 -2,16995 -0,86247 -1,3544 -0,15547 -0,20813 -0,61806 -2,75409 -1,3183 -1,79127 0,014752 0,121401 biocarta_sonic_hedgehog_receptor_ptc1_regulat 0,32248 -0,07674 -0,19408 0,147736 1,413506 0,103482 0,035594 0,578245 -0,2324 -2,16995 -0,86247 -1,3544 -0,15547 -0,20813 -0,61806 -2,75409 -1,3183 -1,79127 0,014752 0,121401 biocarta_stathmin_and_breast_cancer_resistance 0,04465 -0,26926 -0,30609 1,439739 1,322422 1,721727 -1,63589 -1,57014 -1,45002 -2,48985 -2,28748 -2,30729 -1,21177 -0,87837 -0,98445 -4,09664 -2,90488 -2,26297 0,01523 0,121401 biocarta_the_prc2_complex_sets_long_term_gen 0,07647 -0,05265 -0,14418 -0,01436 0,045574 0,00694 1,720996 1,891785 1,380216 -1,07434 -0,61285 -1,01292 -0,05968 0,02286 -0,05034 -3,18392 -2,05048 -2,01224 0,016488 0,121401 biocarta_the_prc2_complex_sets_long_term_gen 0,07647 -0,05265 -0,14418 -0,01436 0,045574 0,00694 1,720996 1,891785 1,380216 -1,07434 -0,61285 -1,01292 -0,05968 0,02286 -0,05034 -3,18392 -2,05048 -2,01224 0,016488 0,121401 biocarta_the_prc2_complex_sets_long_term_gen 0,07647 -0,05265 -0,14418 -0,01436 0,045574 0,00694 1,720996 1,891785 1,380216 -1,07434 -0,61285 -1,01292 -0,05968 0,02286 -0,05034 -3,18392 -2,05048 -2,01224 0,016488 0,121401 biocarta_transcription_factor_creb_and_its_extra 0,116096 -0,28883 -0,51872 -0,34265 1,104059 1,109945 -1,28424 -1,03466 -2,03007 -0,83117 0,406772 -1,54777 -0,48885 0,17444 0,306414 -4,02002 -2,51692 -2,02445 0,015063 0,121401 Chemotaxis_Driven_by_IL-8_and_LTB4 -0,35679 -0,54969 -0,5619 2,435585 1,887218 1,455789 -2,79742 -3,26132 -3,26073 -4,07725 1,51579 -0,06629 -0,58716 -0,36064 0,212138 -7,69321 -6,29212 -4,6599 0,016061 0,121401 Erythropoietin_Pathway_BCLXL_Gene_Expression 0,047814 0,007449 0,030407 -0,90963 -0,21188 -0,28622 0,316043 0,564588 0,337355 1,594228 -0,38444 0,007948 -0,4356 -0,83895 -0,646 -0,39606 0,241948 -0,29036 0,016232 0,121401 Extracellular_Matrix_Remodeling_during_Adhesio -0,23498 -0,22797 0,118668 -3,90117 -2,76851 -2,40434 -2,06889 -2,62162 -1,24536 -0,11944 -0,18684 -0,68729 -1,13976 0,057298 -1,4865 -0,01584 0,324632 1,11704 0,016705 0,121401 Glucocorticoid_Receptor_Signaling_Pathway_Infla 0,641238 -0,24386 -0,00237 0,269268 2,490608 0,03928 4,36103 4,875862 2,523026 -5,35484 -2,62874 -1,76831 -1,77466 0,788021 0,557925 -8,598 -6,11913 -2,60331 0,015252 0,121401 KEGG_Ether_lipid_metabolism_Main_Pathway -0,13129 -0,37662 -0,08841 -0,52898 -2,01832 -1,35685 -3,9821 -4,54237 -2,86727 0,445246 -2,10688 -0,07934 -1,52821 -0,31564 -1,6702 2,054134 3,910805 2,69236 0,015101 0,121401 KEGG_Fatty_acid_biosynthesis_Main_Pathway 0,053612 0,004849 -0,01299 -0,17981 0,032633 0,310232 0,061087 0,134319 -0,11814 -0,90253 0,083081 -0,45191 -0,05205 0,079919 0,124907 -0,9515 -1,13341 -0,84089 0,016631 0,121401 KEGG_Homologous_recombination_Main_Pathwa 0,442907 0,008429 0,183745 1,454926 0,459744 1,531704 3,388365 4,324341 2,616967 -2,4398 -1,41216 0,163712 -0,57137 0,100744 -0,14265 -3,76407 -2,59311 -1,41424 0,017085 0,121401 KEGG_Wnt_signaling_Main_Pathway -2,07056 -1,37017 -1,33818 0,799085 -1,61721 0,13486 -3,29855 -3,08859 -2,23714 -0,62409 -0,38229 0,065152 0,163628 1,396775 0,657082 -3,89875 -1,97437 -0,72453 0,015643 0,121401 NCI_Aurora_B_signaling_Pathway_(cytokinesis) 0,117952 -0,11485 -0,1764 -0,34265 0,004726 0,194318 2,051833 2,111241 1,631586 -2,42859 -2,23496 -2,46444 -0,4271 -0,64235 -1,0139 -2,91095 -2,24254 -1,90028 0,016744 0,121401 NCI_CD40_CD40L_signaling_Pathway_(B_cell_pro -0,0273 0,050749 -0,00609 0,160625 0,076526 0,094419 -0,01663 0,059532 -0,10464 -0,25754 0,145888 -0,46914 -0,0424 0,12099 -0,08117 -0,59353 -0,39306 -0,43857 0,01652 0,121401 NCI_CD40_CD40L_signaling_Pathway_(regulation_ -0,0273 0,050749 -0,00609 0,160625 0,076526 0,094419 -0,01663 0,059532 -0,10464 -0,25754 0,145888 -0,46914 -0,0424 0,12099 -0,08117 -0,59353 -0,39306 -0,43857 0,01652 0,121401 NCI_EPHA_forward_signaling_Pathway_(actin_fila -0,06268 0,150857 0,081693 -1,34405 -2,19501 -2,16625 -0,60026 -0,86923 -0,63794 0,812899 0,510617 0,288612 -0,1493 -0,0394 0,202333 1,11541 1,246241 1,461152 0,014802 0,121401 NCI_EPHA_forward_signaling_Pathway_(axon_gu -0,24359 0,034564 -0,11344 -0,9419 -2,25849 -1,80955 -1,34795 -1,74288 -1,43431 1,580802 0,941789 0,369375 -0,30641 0,112994 0,410175 0,717691 1,668831 1,301321 0,017031 0,121401 NCI_EPHA_forward_signaling_Pathway_(cell_cell_ -0,3092 0,051778 -0,05062 -1,80664 -2,4757 -2,49003 -1,40835 -1,8619 -1,21133 1,819594 1,373338 0,5423 -0,08639 0,19057 0,406348 1,29155 1,696986 1,459648 0,016098 0,121401 NCI_EPHA_forward_signaling_Pathway_(regulatio -0,3092 0,051778 -0,05062 -1,80664 -2,4757 -2,49003 -1,40835 -1,8619 -1,21133 1,819594 1,373338 0,5423 -0,08639 0,19057 0,406348 1,29155 1,696986 1,459648 0,016098 0,121401 NCI_Fc_epsilon_receptor_I_signaling_in_mast_ce -0,05319 -0,04096 0,015514 0,034138 -0,03124 0,358573 0,443835 0,378273 0,552773 0,71933 0,720765 0,640354 -0,18439 -0,1659 -0,14654 0,666722 0,179132 0,476403 0,015736 0,121401 NCI_FOXM1_transcription_factor_network_Main_ 0,17255 -0,0695 -0,05537 1,305093 0,978344 0,475277 -0,10312 0,255613 -0,89095 -0,70036 -0,62924 -0,51122 -0,64262 0,020664 0,027807 -3,68816 -1,99436 -1,76813 0,016965 0,121401 NCI_Netrin_mediated_signaling_events_Pathway_ -0,04158 -0,15526 -0,16728 -0,74755 -0,54261 -0,73948 -0,65229 -0,57929 -0,76169 -1,86579 -1,02106 -1,3259 0,491334 0,471628 0,502788 -2,09883 -2,16994 -2,0877 0,014937 0,121401 NCI_Nongenotropic_Androgen_signaling_Main_P -0,09083 -0,425 -0,51706 0,162517 0,250742 -0,6466 -0,21342 0,275868 -0,67046 -2,27034 -0,68604 -0,50691 -0,00874 -0,02666 0,367207 -4,91629 -4,51758 -2,594 0,017085 0,121401 NCI_p75_NTR_mediated_signaling_Main_Pathwa 0,43018 -0,62477 -0,30417 0,367333 -0,42383 0,140619 -5,5705 -4,65012 -6,95221 -0,92126 -0,95794 -3,53119 1,675191 0,089031 1,55538 -10,1134 -6,83356 -7,50434 0,015355 0,121401 NCI_Plasma_membrane_estrogen_receptor_signa -0,16548 -0,25704 -0,1287 -0,1777 0,113134 -0,34798 -0,88374 -0,93548 -0,77211 -1,21372 -0,47469 -0,70262 0,195343 -0,28335 -0,08574 -0,5219 -0,47767 -0,43296 0,016215 0,121401 NCI_PLK1_signaling_events_Pathway_(microtubu 0,161306 0,033745 0,139577 -0,04638 -0,29858 -0,17215 1,676283 1,876753 1,202763 -1,00452 -1,12156 -1,27907 -0,05716 0,165178 0,090105 -2,09312 -1,76931 -1,3598 0,014944 0,121401 NCI_PLK1_signaling_events_Pathway_(regulation_ 0,263421 0,06869 0,111927 -0,12595 -0,2759 -0,1226 2,561128 2,90196 1,829673 -2,83535 -3,4413 -2,51798 -0,36085 -0,01699 -0,33492 -3,48496 -2,3078 -1,75149 0,015709 0,121401 NCI_S1P2_Main_Pathway -0,06888 -0,49703 -0,66254 0,859571 0,368017 0,124729 -1,03093 -0,85165 -1,05628 -1,65189 -0,21919 -0,12278 -0,37476 -0,68097 -0,02992 -3,34235 -3,16853 -3,371 0,01707 0,121401 NCI_Signaling_events_mediated_by_HDAC_Class_ -0,29215 -0,33348 -0,51294 -0,43727 0,458697 -0,73778 -1,38154 -1,38218 -2,27503 -3,6241 -2,72645 -0,32283 0,287796 0,515964 1,167533 -10,0685 -6,79095 -4,95759 0,016333 0,121401 NCI_Signaling_events_mediated_by_TCPTP_Pathw 0,097094 -0,07661 -0,10024 -0,02711 -0,46756 -0,42183 -0,56514 -0,37763 -1,0321 -1,55336 -0,29203 -0,40638 0,645772 0,889371 0,58808 -2,60428 -2,18628 -1,45896 0,015348 0,121401 NCI_Stabilization_and_expansion_of_the_E_cadh -0,35087 -0,00233 -0,21109 1,692367 0,644221 0,401937 -1,42945 -1,89734 -1,871 -1,66529 0,185322 -0,866 -0,59793 0,438725 0,319318 -6,08897 -3,14503 -3,11458 0,015192 0,121401 NCI_TGF_beta_receptor_signaling_Pathway_(JNK_ -0,04862 -0,17 -0,09149 -0,23545 -0,2086 -0,37147 -0,54307 -0,3082 -0,80546 -1,04743 -0,74148 -0,9279 -0,00021 -0,01727 -0,07387 -1 -0,69685 -0,35993 0,016826 0,121401 RANK_Signaling_in_Osteoclasts_Pathway -0,34335 -1,13573 -1,0863 -0,52416 -1,74902 -1,44484 -3,7064 -2,38592 -4,90821 -2,02218 -3,59498 -0,82002 1,277514 1,025715 2,35441 -6,68458 -4,74264 -2,37331 0,016253 0,121401 reactome_Abortive_elongation_of_HIV_1_transcr 0,346505 -0,22322 -0,33395 0,664592 0,238312 0,14325 -0,07862 0,376862 -0,74287 -2,62806 -2,07708 -0,6182 -0,57071 -0,42494 -0,08289 -5,62791 -4,91325 -3,68587 0,016858 0,121401 reactome_Adrenaline_signalling_through_Alpha_ -0,14743 -0,01118 -0,04701 -0,27787 0,0216 -0,27157 0,087734 -0,09898 0,190002 -0,0332 0,212051 -0,04438 -0,00447 -0,17265 -0,15211 0,183164 0,265508 0,185358 0,014478 0,121401 reactome_Butyrate_Response_Factor_1_BRF1_de 0,13936 -0,28344 -0,15482 0,940122 0,098269 0,080138 -0,89214 -0,60064 -1,52012 -2,33668 -0,53134 -1,33187 0,120012 -0,03373 0,293389 -6,86453 -5,08753 -5,44067 0,016743 0,121401 reactome_Cyclin_D_associated_events_in_G1_Ma 0,473142 -0,29193 -0,34845 0,265915 1,062126 0,057272 1,239148 1,958107 -0,53241 -4,69092 -1,20014 -0,69713 0,770829 1,145843 1,214921 -11,9867 -9,50274 -6,97298 0,015972 0,121401 reactome_Cytosolic_iron_sulfur_cluster_assembly 0,143021 -0,14751 0,046249 0,184258 0,49112 -0,22052 0,190829 0,252053 0,137608 -0,87243 -2,32849 -0,10509 0,410748 0,457477 0,55012 -0,06397 -1,17657 -0,33395 0,014483 0,121401 reactome_Downregulation_of_SMAD2_3_SMAD4 0,074847 -0,17354 -0,30963 0,220709 0,665774 0,195569 1,767042 2,301775 0,959428 -1,13441 0,39938 -0,14117 1,144138 1,169426 1,061398 -6,1068 -3,57807 -2,56894 0,014929 0,121401 reactome_Formation_of_HIV_elongation_comple 1,035391 -0,21334 -0,43185 1,489198 1,295366 0,774078 -1,1444 0,050929 -2,69844 -3,51706 -1,85223 -0,50123 0,013735 0,215671 0,343316 -10,1203 -8,76036 -6,39107 0,016402 0,121401 reactome_Formation_of_RNA_Pol_II_elongation_ 1,035391 -0,21334 -0,43185 1,489198 1,295366 0,774078 -1,1444 0,050929 -2,69844 -3,51706 -1,85223 -0,50123 0,013735 0,215671 0,343316 -10,1203 -8,76036 -6,39107 0,016402 0,121401 reactome_G_alpha_i_signalling_events_Main_Pat -4,97783 0,707155 1,07292 4,094439 4,775009 1,196824 -0,30873 -6,6373 7,300131 16,29039 11,01653 9,376979 -2,45002 -3,33274 -3,74779 27,88026 25,97031 19,35888 0,016957 0,121401 reactome_Inactivation_of_Cdc42_and_Rac_Main_ -0,04124 -0,23678 -0,18087 -1,27024 -1,48183 -1,28597 -2,03071 -1,73787 -2,26881 -0,49425 -0,10239 -0,24754 -0,94189 -0,10175 -0,06966 0,239156 0,237055 1,045051 0,01633 0,121401 reactome_ISG15_antiviral_mechanism_Main_Pat 1,017519 -0,10491 0,026762 1,054416 1,698727 -0,20542 1,010563 2,325059 -1,7767 -9,40455 -1,95048 -4,4096 0,53664 0,267296 0,764088 -19,7119 -13,9897 -11,2623 0,016802 0,121401 reactome_KSRP_destabilizes_mRNA_Main_Pathw 0,36932 -0,16738 -0,19065 1,142247 0,726522 -0,13986 0,127574 0,386538 -0,72069 -2,64411 0,005646 -0,98204 0,203689 -0,00355 0,603097 -6,44676 -4,91273 -5,17243 0,0165 0,121401 reactome_Mismatch_repair_MMR_directed_by_M 0,39916 0,187464 0,13378 0,86844 0,692426 0,695997 3,126284 3,521515 2,835525 -1,68812 -0,38463 -0,22643 -0,05032 0,060821 0,090884 -3,4759 -3,34611 -2,60348 0,015689 0,121401 reactome_Mitotic_Prometaphase_Main_Pathway 1,941304 0,025181 -0,06529 2,433072 2,844146 1,373782 10,90001 12,95751 6,3193 -12,9489 -5,0737 -8,88246 -2,53464 -1,31069 -1,20012 -25,4162 -17,2564 -13,0802 0,016607 0,121401 reactome_NOTCH1_Intracellular_Domain_Regulat 0,297726 -0,28027 -0,33182 -0,31599 -0,61364 -0,58629 -0,78358 -0,47783 -1,82325 -2,23063 -1,53339 -2,62977 0,617964 0,126023 1,231171 -7,93398 -6,29619 -4,05915 0,017109 0,121401 reactome_Phosphorylation_of_CD3_and_TCR_zet -0,77074 0,594807 0,054483 -0,58402 0,439271 1,253908 -0,02387 -0,61367 1,451013 1,401797 1,638954 2,328867 -0,38797 -0,47629 -0,47734 4,657776 3,663431 4,274996 0,014917 0,121401 reactome_Post_chaperonin_tubulin_folding_Main -0,0142 -0,35234 -0,17893 0,023141 0,180988 -0,57647 -1,53124 -1,54488 -1,60267 -2,16954 -1,92773 -0,86165 0,002136 -0,46489 0,070624 -4,98494 -4,16112 -3,321 0,015337 0,121401 reactome_Regulation_of_IFNG_signaling_Main_P 0,218508 -0,14567 -0,08885 -0,11511 1,056118 0,322298 -0,04933 -0,2301 -0,26498 -1,4001 -0,34899 -0,17312 -0,30851 0,590321 0,552349 -3,12334 -2,21894 -0,4467 0,016451 0,121401 reactome_Response_to_elevated_platelet_cytoso -0,05704 -0,14828 0,076285 -0,41728 -0,45086 -0,88266 -0,09467 0,007198 0,069594 0,533945 -0,11509 -0,50209 -0,2843 -0,24978 0,152349 1,060825 1,053431 1,257453 0,016016 0,121401 reactome_RNA_Polymerase_II_Transcription_Elon 0,919513 -0,18974 -0,40438 1,268501 1,119261 0,455763 -0,9725 0,139264 -2,41162 -3,47003 -1,57558 -0,46558 0,040395 0,434839 0,507143 -9,62039 -8,09828 -5,9059 0,016667 0,121401 reactome_Signaling_by_NOTCH4_Main_Pathway 0,138662 0,164276 -0,00722 -0,36347 0,979943 0,353164 -1,01528 -0,92931 -1,03092 -0,64503 0,535642 -0,26292 0,854863 1,088783 0,852495 -1,39262 -0,0353 -0,40571 0,014803 0,121401 reactome_Synthesis_of_bile_acids_and_bile_salts -0,20933 0,065224 0,191486 -1,28538 -0,57654 -2,0381 -1,8044 -2,60163 -1,708 0,384166 0,866001 0,917714 0,527109 -0,04816 0,371553 2,88012 2,008111 1,911106 0,016677 0,121401 reactome_Synthesis_of_very_long_chain_fatty_ac 0,090511 0,209213 -0,09445 -1,72574 -2,4038 -3,06289 -0,16658 -0,38273 -0,8594 3,568077 1,298617 0,702393 -0,53481 -1,04095 -0,38428 -2,26062 -0,17676 -0,06897 0,014897 0,121401 reactome_Transcriptional_activation_of_mitocho 0,159311 -0,26338 -0,28156 -0,27145 -1,81727 0,431917 -0,26859 0,423926 -1,1828 -2,46692 -1,47592 -1,42704 0,630465 0,401413 1,434485 -5,45242 -4,14354 -2,93532 0,015418 0,121401 VEGFR2_Signaling -0,07169 -1,56163 -1,31622 -1,27731 1,698623 -0,09225 -5,94796 -3,88533 -7,50674 0,268541 -1,00789 -1,77086 1,954548 0,660876 2,523452 -9,89952 -5,45813 -1,97966 0,015454 0,121401 WNT_Pathway_Gene_Expression_via_CREB3 0,124734 -0,72412 -0,80569 2,687825 3,068213 1,19024 -1,82612 -1,66156 -2,62591 -3,89227 1,48375 -1,66587 0,046137 -0,6835 0,506734 -3,07686 -2,89763 0,200229 0,015359 0,121401 NCI_Neurotrophic_factor_mediated_Trk_recepto 0,031254 -0,36038 -0,3041 -0,91271 -0,6548 0,006267 -2,7911 -2,72606 -3,13894 -1,73399 -1,41063 -2,53644 0,23235 0,5148 0,156269 -1,34235 -0,74296 -1,20839 0,017357 0,122583 reactome_Integrin_alphaIIb_beta3_signaling_Mai -0,39157 -0,30627 -0,2722 -1,2863 -1,19393 -1,53669 -0,80192 -1,12318 -0,67562 -0,55614 0,380029 -1,64463 -0,44693 -0,40558 -1,19622 0,717781 -0,09767 0,473529 0,017383 0,122583 reactome_Telomere_C_strand_Lagging_Strand_S 0,183191 0,055898 0,077381 -0,00424 0,357256 0,296916 0,958425 1,009804 0,822916 -1,37911 -0,59904 -0,54878 0,062879 -0,10343 -0,24042 -0,61137 -0,91559 -0,53135 0,017394 0,122583 reactome_RNA_Polymerase_I_Promoter_Escape_ 0,729896 -0,06964 -0,28343 2,014962 1,454178 0,154341 -2,67581 -1,69168 -4,28109 -2,31338 -1,05702 -0,27368 0,7291 0,760573 0,992343 -10,7191 -9,00844 -7,94312 0,017439 0,122623 KEGG_Maturity_onset_diabetes_of_the_young_M -0,03911 -0,04215 -0,01135 0,012494 -0,0155 0,027492 -0,01539 0,004513 0,101975 0,45421 0,199354 0,393614 -0,0352 -0,09594 -0,02283 0,303772 0,308425 0,016521 0,017629 0,1234 reactome_Regulation_of_gene_expression_in_lat -0,03911 -0,04215 -0,01135 0,012494 -0,0155 0,027492 -0,01539 0,004513 0,101975 0,45421 0,199354 0,393614 -0,0352 -0,09594 -0,02283 0,303772 0,308425 0,016521 0,017629 0,1234 reactome_RNA_Polymerase_III_Chain_Elongation 0,100924 -0,16139 -0,43705 0,265774 -0,04805 -0,68381 -0,32709 0,237735 -1,32184 -1,80997 -0,92747 -1,65896 0,32005 0,501189 0,415488 -6,87859 -5,7123 -4,74845 0,017694 0,123577 JAK-STAT_Pathway_Nml_SOCS_BCL-XL_p21_Myc_ -3,64479 -1,18921 -0,06367 -11,2212 -5,28921 -7,43069 -10,3057 -14,5068 -2,22722 14,28711 -0,24953 0,452967 0,13768 -1,60027 -2,37499 38,04896 33,38059 29,00369 0,017754 0,123675 KEGG_Calcium_signaling_Main_Pathway -0,25136 -0,30924 -0,04037 -5,80803 -3,41562 -7,0499 -3,50503 -4,48241 -1,73457 5,076169 1,204394 1,514491 1,734953 0,867218 1,624449 9,498583 9,700175 11,10353 0,017787 0,123675 NCI_Endogenous_TLR_signaling_Pathway_(regula 0,027273 -0,11235 -0,14572 -1,00148 -1,14381 -0,79292 -2,58013 -2,30877 -2,6328 1,451665 1,73881 1,254953 -0,58746 -1,29171 -0,69342 -0,73118 -1,14121 -0,95528 0,018043 0,123799 reactome_Formation_of_HIV_1_elongation_comp 0,99964 -0,20327 -0,44077 1,61505 1,356627 0,779641 -1,01352 0,146789 -2,48033 -3,37183 -1,44374 -0,20575 -0,06572 0,170846 0,309686 -9,70956 -8,55275 -6,25331 0,018083 0,123799 reactome_Neurofascin_interactions_Main_Pathw -0,05856 -0,01988 -0,00739 -0,68757 -0,81177 -0,88977 -1,00174 -0,92949 -1,1834 -0,83669 0,261434 -0,70488 -0,55081 -0,41349 -0,34847 1,116454 1,527169 2,084449 0,017889 0,123799 reactome_RNA_Polymerase_I_Transcription_Initia 0,901802 -0,15863 -0,6072 1,430508 0,954917 -0,72742 -1,21702 -0,14801 -3,60932 -5,49026 -2,15772 -1,28711 0,636249 1,144676 1,009503 -15,2239 -12,7371 -10,9692 0,018013 0,123799 reactome_Serotonin_receptors_Main_Pathway -0,48796 -0,24375 0,072384 0,567668 -0,26972 -0,29213 0,226452 -0,10915 1,574717 1,459351 0,109243 1,540087 -0,21456 -0,59909 -0,45976 3,005984 1,33761 2,049011 0,018077 0,123799 reactome_TCF_dependent_signaling_in_response -0,20695 -0,38113 -0,24735 1,484855 0,134158 1,252665 1,608447 1,561798 1,491253 -1,12846 -0,03396 -0,51405 0,093366 0,330401 0,177566 -0,23762 0,234786 0,03222 0,01805 0,123799 reactome_Tristetraprolin_TTP_destabilizes_mRNA 0,095162 -0,32003 -0,15061 1,370799 -0,37949 0,298347 -1,01842 -0,56799 -1,53775 -2,2768 -0,56633 -1,257 0,114895 -0,15264 0,435334 -7,37963 -5,76218 -5,54085 0,017913 0,123799 biocarta_chaperones_modulate_interferon_signa 0,005813 -0,14227 -0,07978 0,262683 -0,27957 0,50588 0,257612 0,338365 -0,01379 -0,02205 -0,14424 -0,41902 0,063631 -0,01903 0,522011 -1,95305 -1,34913 -0,80178 0,018309 0,124185 biocarta_segmentation_clock_Main_Pathway 0,12007 0,141405 0,011149 0,112151 0,348285 0,218059 -1,16248 -1,25063 -1,45618 -0,16286 0,005401 -0,7839 0,337186 0,402307 0,308578 0,098515 -0,36318 0,414819 0,018559 0,124185 inositol_pyrophosphates_biosynthesis -0,09919 -0,19058 -0,11203 -0,31371 0,559142 -0,23568 -1,23715 -1,23376 -1,67969 0,30228 -1,34617 -0,69893 0,016121 0,26911 0,155551 -0,64163 -1,54618 -0,96558 0,018519 0,124185 KEGG_Intestinal_immune_network_for_IgA_prod 0,020806 -0,31488 -0,10701 -0,25742 -0,61578 -0,49949 -0,35131 -0,09839 0,137972 0,481284 0,661863 0,727033 0,10007 0,072827 -0,14016 0,410507 0,30437 -0,03034 0,018334 0,124185 NCI_Signaling_events_mediated_by_HDAC_Class_ -0,10449 0,011017 -0,20345 -0,29277 -0,33848 0,051504 1,246107 1,340328 0,907942 -2,45032 0,064897 -0,96432 0,251344 0,230127 0,426368 -4,02067 -2,95432 -2,78091 0,018605 0,124185 reactome_Adenylate_cyclase_inhibitory_Main_Pa -0,2409 -0,18123 -0,17182 0,081315 0,247536 -0,19592 -1,29086 -1,04908 -1,26931 -1,6441 -1,83012 -0,90207 0,20107 0,550265 0,495159 0,233761 -0,29067 0,21398 0,018657 0,124185 reactome_Adrenoceptors_Main_Pathway -0,24234 -0,08725 0,075076 -0,44159 -0,76006 -1,57025 -0,1867 -0,67988 0,609304 -0,0442 0,372977 -0,67886 0,146438 -0,42489 -0,60028 0,845314 1,006094 0,574861 0,018689 0,124185 reactome_Cyclin_E_associated_events_during_G1 0,408333 -0,04579 -0,12447 2,092774 2,357238 0,387764 1,245076 1,804892 0,692302 -0,7269 -0,13722 -0,04953 -0,02221 0,195985 -0,13066 -5,41658 -4,14331 -3,45619 0,018238 0,124185 reactome_Resolution_of_AP_sites_via_the_multi 0,155885 0,020055 0,081832 0,030637 0,457223 0,293967 0,644299 0,674808 0,524244 -1,41037 -0,50505 -0,01467 0,131351 -0,15857 -0,12887 -0,81526 -1,0046 -0,80735 0,018371 0,124185 reactome_RNA_Polymerase_III_Transcription_Init 0,003099 -0,33246 -0,6585 0,121739 -0,23333 -0,92683 -0,87508 -0,10756 -2,20408 -2,76685 -1,39514 -1,80526 0,238606 0,493681 0,425165 -8,96908 -7,29375 -6,21088 0,018502 0,124185 reactome_SMAC_binds_to_IAPs_Main_Pathway 0,085296 -0,02662 0,08827 0,573871 -0,11996 0,527501 -0,14519 0,005664 -0,36153 0,042436 -1,03687 -0,92388 -0,04685 -0,30736 -0,03009 -1,35874 -0,94739 -1,02892 0,018698 0,124185 reactome_SMAC_mediated_dissociation_of_IAP_ 0,085296 -0,02662 0,08827 0,573871 -0,11996 0,527501 -0,14519 0,005664 -0,36153 0,042436 -1,03687 -0,92388 -0,04685 -0,30736 -0,03009 -1,35874 -0,94739 -1,02892 0,018698 0,124185 reactome_Sodium_coupled_sulphate_di_and_tri_ -0,04396 0,133116 -0,09493 -0,3176 -0,10848 -0,12033 0,270493 0,093008 0,62608 0,263766 -0,64383 0,444956 -0,33567 -0,51241 -0,13017 0,90953 1,358014 0,93097 0,018263 0,124185 reactome_Tat_mediated_elongation_of_the_HIV_ 0,883762 -0,17967 -0,4133 1,394353 1,180522 0,461326 -0,84162 0,235124 -2,1935 -3,3248 -1,16709 -0,1701 -0,03906 0,390015 0,473513 -9,20966 -7,89066 -5,76813 0,01849 0,124185 reactome_Receptor_ligand_binding_initiates_the_ 0,159889 0,106463 0,018304 -0,26747 0,459941 -0,01443 0,084157 0,217832 -0,02634 -1,03323 0,264178 -0,28918 0,641412 0,570782 0,701331 -2,94876 -2,19786 -1,44799 0,018746 0,12424 terminal_iOi-glycans_residues_modification -0,06831 -0,37803 -0,24476 0,837818 0,046751 0,304978 -0,53366 -0,50838 -1,04605 0,213717 0,24048 -0,75991 0,030577 0,102845 0,509156 -1,53439 -3,25324 -1,58504 0,018845 0,124633 AHR_Pathway 0,340658 -0,17492 -0,18134 0,226865 -0,00791 0,674021 -1,51308 -0,66914 -2,50438 -0,7879 -1,64749 -2,40693 0,399491 0,532964 0,275576 -8,81885 -6,59528 -5,92124 0,019132 0,125203 NGF_Pathway_Gene_Expression_via_MYC_ELK1_ -0,31645 -0,31336 -0,2853 0,048285 0,383694 0,093586 -1,89744 -1,92494 -2,1539 -1,18484 0,698303 1,177471 1,074954 0,661165 1,494889 -0,91213 -1,47897 -0,59099 0,019078 0,125203 reactome_Phosphorylation_of_Emi1_Main_Pathw 0,00156 -0,1335 -0,22277 -0,12054 0,385986 -0,65838 1,483992 1,657474 1,227508 -2,12615 -1,90711 -1,33504 -0,3512 -0,16597 -0,24782 -1,4574 -1,04879 -0,71212 0,019132 0,125203 UDP-iNi-acetyl-D-galactosamine_biosynthesis_II 0,420362 0,16517 0,044679 -0,62669 0,321142 0,467908 -0,61383 -0,50209 -1,03145 -0,68216 -1,08787 -0,42926 0,063433 0,469422 0,436379 -2,4794 -2,30567 -2,13307 0,019049 0,125203 WNT_Pathway_PKC_Pathway -0,0715 -0,68083 -0,6889 0,835521 1,612946 -0,81904 -1,45815 -1,24332 -1,84879 -3,65185 0,344936 -3,35641 0,185916 -0,60041 0,52923 -3,31024 -3,14948 0,42694 0,019027 0,125203 biocarta_erk_and_pi_3_kinase_are_necessary_fo 0,076806 -0,04805 0,01452 0,138793 -0,3228 -0,20067 -0,51421 -0,47569 -0,58539 0,033207 0,438291 0,006092 -0,0471 -0,04772 -0,05052 0,142537 0,292938 0,387334 0,019237 0,125472 biocarta_inhibition_of_cellular_proliferation_by_g -0,10972 -0,55575 -0,50544 0,013394 0,809546 0,584441 -0,23075 0,356459 -1,02366 -1,19725 -0,00739 -0,22037 -0,32385 -0,39416 0,021908 -3,37837 -1,70028 -1,12131 0,019328 0,125472 KEGG_Linoleic_acid_metabolism_Main_Pathway -0,23241 0,030069 0,053331 -0,06688 -0,85182 0,08997 -0,58205 -1,27342 1,208631 0,862923 -0,46907 1,611341 -0,55747 0,200915 -0,46592 2,380261 2,925587 1,101927 0,019375 0,125472 KEGG_Ubiquitin_mediated_proteolysis_Main_Pat 1,89502 -0,74284 -0,33997 -0,14488 -0,41721 -2,14 -6,63788 -3,85335 -12,4629 -12,005 -5,96732 -8,86282 1,643584 0,999982 3,377816 -35,3642 -28,0423 -20,7942 0,019367 0,125472 oleate_biosynthesis -0,04997 0,028347 -0,26692 -0,84452 -1,52365 -0,70533 -0,24692 -0,31285 -0,31056 1,382159 0,878667 0,921596 -0,1354 0,124794 -0,25455 -0,06425 -0,10499 0,003519 0,019271 0,125472 KEGG_Transcriptional_misregulation_in_cancer_M -2,84263 -3,40064 -2,58437 -2,71501 0,031683 -1,41752 -7,09552 -8,62883 -5,6943 -1,05081 -7,22424 -1,84391 5,24428 2,783218 5,431209 -3,23416 -3,82948 -1,81791 0,019448 0,125687 NCI_Regulation_of_Telomerase_Main_Pathway 0,478543 0,099118 -0,12432 0,453137 1,251862 -1,674 0,895174 1,284738 -0,51609 -3,73982 -2,38184 -2,58331 -0,45556 0,023457 0,291515 -8,78117 -7,16066 -4,90478 0,019534 0,125978 biocarta_p53_signaling_Main_Pathway -0,0082 -0,06838 -0,1661 1,162734 1,012153 0,48484 0,84677 0,957216 0,526726 0,192278 -0,08108 -0,21602 -0,15147 0,017269 0,052433 -3,13279 -2,74881 -1,78906 0,019859 0,125987 JAK-STAT_Pathway -3,66508 -1,68571 0,034896 -12,8196 -3,99803 -9,78222 -9,56731 -13,5937 -2,38259 14,83479 1,198106 6,567884 3,01512 1,536979 3,078319 31,71731 29,50802 25,40857 0,019846 0,125987 KEGG_Amoebiasis_Main_Pathway 0,155128 -0,07008 0,058335 -1,36113 -0,6619 -1,76093 -1,28204 -1,40208 -1,11083 1,967005 -0,34624 2,01389 -0,40448 -0,86499 -0,41936 -0,127 -1,08561 -0,61855 0,019688 0,125987 KEGG_Spliceosome_Main_Pathway 3,03994 -0,02067 0,23948 6,041015 5,065914 7,385674 3,473506 6,46542 -2,11876 -7,33769 -3,87037 -5,13431 0,866227 1,006844 2,160462 -45,2818 -35,2756 -27,9174 0,019823 0,125987 mRNA_capping 0,131554 -0,1671 -0,04945 0,366489 0,454632 0,069916 -0,19563 0,025686 -0,49279 0,01384 0,198565 0,410241 0,290041 0,287484 0,214176 -1,13153 -0,7972 -0,89633 0,019599 0,125987 NCI_PLK1_signaling_events_Pathway_(regulation_ 0,159103 -0,00512 0,077764 -0,05925 -0,34794 -0,24421 1,533908 1,750683 1,069174 -0,74422 -0,95541 -1,1612 -0,06828 0,170563 0,073732 -1,7745 -1,50886 -1,00426 0,019813 0,125987 NGF_Pathway -0,95298 -1,37622 -1,42625 -1,30403 1,102722 -0,33401 -3,98349 -3,34711 -6,12485 -1,83698 -0,27653 2,215989 2,358723 2,307488 3,158898 -11,8599 -8,92634 -5,46946 0,01979 0,125987 reactome_RNA_Polymerase_III_Transcription_Init -0,02478 -0,61068 -0,76873 0,967698 0,507005 -0,02968 -1,44077 -0,71807 -2,75373 -2,51812 -0,57508 -0,87506 -0,0912 0,704844 0,198352 -10,116 -8,01073 -7,20975 0,019676 0,125987 reactome_negative_regulation_of_TCF_dependen -0,21216 -0,05912 0,076626 -1,24484 -0,35652 -1,25311 -0,69503 -0,66248 -0,09536 0,248196 0,169861 0,726119 0,276571 -0,3294 0,00311 0,973233 1,026864 0,450279 0,019906 0,126028 MAPK_Family_Pathway_Gene_Expression_via_AT 0,159025 -0,0729 -0,0998 -0,36968 -1,37187 0,474389 -0,19138 0,505371 -0,93526 -2,40217 -1,11936 -2,65816 1,000597 1,220052 1,801199 -1,85245 -2,25537 -0,39114 0,020144 0,127277 NCI_VEGFR1_specific_signals_Main_Pathway -0,09745 -0,10801 -0,24405 -0,54316 -0,09079 -0,43721 -1,95838 -2,0369 -1,92846 -0,36245 -1,88983 -0,78173 0,286632 0,251358 0,09546 -1,43965 -1,20947 -0,63471 0,020293 0,12796 reactome_mRNA_Capping_Main_Pathway 0,938406 -0,18279 -0,33228 1,145719 1,403787 0,835911 -1,38387 -0,16101 -2,70908 -3,08599 -1,4499 0,218193 0,074398 0,25999 0,044898 -9,10709 -7,63821 -6,65188 0,020377 0,12823 iNi-acetylglucosamine_degradation_I 0,102638 0,07319 -0,03448 -0,2804 0,182695 0,129882 -0,68223 -0,56263 -0,81137 -0,71621 -0,21557 -0,04143 0,047681 0,186642 0,254898 -1,30791 -1,33536 -1,10375 0,020502 0,128257 NCI_Ephrin_B_reverse_signaling_Pathway_(cell_a -0,21652 -0,13549 -0,3424 0,181566 1,460574 0,182273 -1,99624 -2,12738 -1,89052 -0,4672 -0,57491 -0,20411 0,217844 0,232949 0,55189 0,24054 -0,13479 0,030599 0,020546 0,128257 reactome_DCC_mediated_attractive_signaling_M 0,127283 -0,087 -0,30604 -0,51662 -0,07523 -0,57378 -0,89686 -0,76555 -1,31603 -2,86978 -0,67595 -1,30423 -0,2038 0,21222 0,154075 -4,2498 -3,81249 -3,22012 0,020545 0,128257 reactome_Regulation_of_APC_C_activators_betw 0,548462 -0,23282 -0,17057 -0,25641 -0,53646 -2,17795 1,286461 1,929201 -0,0948 -6,01514 -3,22914 -3,31562 -0,51352 0,140618 0,033147 -8,69097 -7,38564 -6,06311 0,020521 0,128257 AHR_Pathway_Cath_D_expression_via_SP1 0,285594 -0,01715 -0,04468 0,519027 0,478125 0,759256 -0,4468 0,070554 -0,92385 0,627761 -0,83066 -2,08184 0,305996 0,505453 -0,20324 -4,97176 -4,01487 -3,28879 0,020777 0,1294 NCI_ALK1_signaling_events_Pathway_(sprouting_ -0,09051 -0,05248 -0,1072 -0,56855 -0,31717 -0,35544 -0,56115 -0,63915 -0,72593 -0,18753 0,163941 0,378822 -0,1438 -0,11579 -0,10711 -0,03146 -0,2635 0,201674 0,020812 0,1294 reactome_RNA_Pol_II_CTD_phosphorylation_and 0,822528 -0,15919 -0,30482 0,925022 1,227682 0,517596 -1,21196 -0,07268 -2,42225 -3,03897 -1,17325 0,25384 0,101057 0,479158 0,208726 -8,60719 -6,97612 -6,1667 0,021022 0,130188 reactome_RNA_Polymerase_I_Transcription_Term 0,886905 -0,03678 -0,25902 1,657747 1,210953 -0,07016 -2,55557 -1,58304 -4,16316 -1,9828 -1,20262 -0,09199 0,789876 0,930648 1,145232 -10,7468 -8,94959 -8,04747 0,020997 0,130188 reactome_Prostanoid_ligand_receptors_Main_Pa -0,32147 0,139281 0,157778 -0,4703 -0,68967 0,045238 0,420672 -0,28216 0,980132 0,675544 -0,11956 0,18979 -0,03703 0,251689 -0,28445 1,75824 1,935408 1,341323 0,021096 0,130386 reactome_Resolution_of_Sister_Chromatid_Cohe 2,268337 0,081302 -0,02911 2,961228 2,852948 1,472445 12,54665 14,81127 7,234366 -13,5968 -4,41494 -8,90608 -2,94635 -1,44235 -1,52711 -28,1139 -19,0465 -13,7716 0,021205 0,130797 NCI_E2F_transcription_factor_network_Main_Pat -0,01658 -0,09946 -0,01659 -0,10144 0,308897 -0,11627 1,546662 1,655179 1,097928 -0,02288 -0,40978 -0,65285 -0,19373 0,05135 0,203413 -1,70489 -1,28782 -1,2229 0,021502 0,131586 reactome_IRF3_mediated_activation_of_type_1_ 0,326153 0,129205 0,085585 0,11521 0,785506 0,377395 -0,22853 -0,1949 -0,12713 -0,91929 -0,28822 -0,36686 0,265513 -0,13167 -0,09752 -0,84862 -0,60737 -0,28849 0,021454 0,131586 reactome_Mismatch_repair_MMR_directed_by_M0,388755 0,128502 0,050762 0,682935 0,606402 0,654603 2,629236 3,080112 2,299079 -1,71504 -0,07912 0,044877 0,025644 0,194066 0,222855 -3,9023 -3,77056 -2,97416 0,021497 0,131586 reactome_Processing_of_Capped_Intron_Contain 0,835436 0,095051 -0,10666 1,589859 -0,50615 -0,09602 1,924019 2,851914 0,672774 -4,85313 -3,95618 -2,2118 -0,65465 -0,31464 0,033072 -12,3345 -9,5313 -7,38011 0,021376 0,131586 Akt_Signaling_Pathway_Aggregation_and_Neurod -0,10412 -0,07057 0,364371 -0,93897 0,72359 -1,21965 1,371475 1,146622 1,682396 0,619414 1,586718 -0,11157 0,258716 0,13637 -0,268 2,218375 2,0966 2,499837 0,021981 0,131608 ILK_Signaling_Pathway_Cytoskeletal_Adhesion_Co -1,90771 -0,88878 -0,12501 -9,52615 -6,44291 -6,61156 -13,2829 -14,7223 -8,89591 3,316874 0,32788 2,91601 2,380058 0,823557 0,50692 13,31399 11,02923 9,193569 0,022076 0,131608 Mismatch_Repair_in_Eukaryotes_Pathway 0,56758 0,282244 0,239765 0,376026 0,912926 0,619673 3,909499 4,693715 3,20307 -2,81205 -0,86793 -0,30023 0,024339 0,443751 0,679864 -7,14641 -5,73188 -4,49087 0,021658 0,131608 NCI_Alpha_synuclein_signaling_Pathway_(Pathwa 0,078576 -0,02379 0,133652 -0,04908 0,14256 -0,37846 -1,1238 -1,13804 -1,11578 -0,27368 0,124571 0,480456 -0,15913 -0,10075 -0,36845 1,157755 0,418094 0,25001 0,022042 0,131608 NCI_Neurotrophic_factor_mediated_Trk_recepto -0,03984 -0,22601 -0,09168 -0,11718 0,493139 0,900564 -1,35393 -1,62365 -1,73195 -0,15857 -0,05528 -0,23491 -0,01588 0,108207 0,216531 -1,01721 -0,18703 -0,16602 0,021782 0,131608 NCI_p73_transcription_factor_network_Main_Pat -0,05123 -0,17746 -0,33416 -0,8786 0,186454 0,835142 -2,33529 -1,93301 -3,0821 -0,67935 -1,8134 -0,36521 -0,06319 -0,02865 -0,18971 -2,40667 -1,44324 -1,289 0,021754 0,131608 NCI_Signaling_events_mediated_by_VEGFR1_and -0,00555 -0,14882 -0,11884 -0,05412 -0,05645 -0,17066 -0,32662 -0,2654 -0,21929 0,707224 0,515895 0,469864 0,071048 -0,08576 0,048575 0,391474 0,293723 0,132962 0,021724 0,131608 NCI_TRAIL_signaling_Main_Pathway -0,09284 0,13284 -0,26161 0,083511 0,417997 1,267875 -0,97507 -0,9306 -1,19208 0,105826 0,850484 -0,23529 0,212277 0,323235 0,748496 -1,63816 -0,78823 -0,23885 0,022097 0,131608 reactome_A_third_proteolytic_cleavage_releases 0,028293 -0,0374 -0,03421 0,142835 0,389363 -0,22563 0,011015 0,100034 -0,19133 -0,61543 -0,11806 0,39493 0,453609 0,670977 0,583055 -1,40924 -0,06871 -0,20949 0,022096 0,131608 reactome_Formation_of_the_active_cofactor_UD 0,088099 -0,02585 -0,04643 -0,00837 0,168526 0,087769 -0,01951 0,059824 -0,27414 -0,83287 -0,382 -0,32793 -0,1138 0,021935 0,066557 -2,31011 -1,84723 -1,67672 0,021686 0,131608 reactome_Metabolism_of_polyamines_Main_Pat 0,107193 0,070891 0,068133 -0,03977 -0,23496 -0,0562 -0,1059 -0,11057 -0,25929 -0,91651 -0,27884 -0,04895 0,441509 0,274809 0,335963 -1,63259 -0,94488 -0,92345 0,021915 0,131608 reactome_Regulation_of_lipid_metabolism_by_Pe -0,16506 -0,15187 -0,0921 0,533987 -1,23788 0,736603 0,08336 0,369175 -0,30515 -1,20895 -0,64412 -0,49308 0,833877 0,384787 1,198888 -1,57363 -0,96446 -1,13699 0,021883 0,131608 tyrosine_degradation -0,04566 0,185541 -0,02733 -1,16833 -1,24515 -1,69993 0,368233 0,500349 0,616041 0,765216 -0,13623 0,368956 -0,37752 -0,05012 -0,44701 -0,29312 -0,45818 -0,34589 0,0218 0,131608 Ubiquitin-Proteasome_Dependent_Proteolysis_Pa 2,265665 0,481452 0,395151 0,083961 -2,62641 -2,87011 -2,7792 -0,70629 -8,44691 -16,0022 -3,58968 -6,90231 2,768747 4,478075 5,207812 -36,0998 -25,1598 -20,9838 0,022006 0,131608 biocarta_cell_cycle_g1_s_check_point_Main_Path 0,005043 -0,3757 -0,2156 1,713129 1,543145 -0,02576 1,391776 1,364196 0,995779 0,05176 -0,12773 -0,44198 -0,00317 -0,11518 -0,07233 -4,52914 -4,73154 -3,65485 0,022166 0,131771 reactome_Insulin_like_Growth_Factor_2_mRNA_ 0,010841 -0,05139 -0,00079 -0,16643 0,338271 -0,09942 -1,35551 -1,39904 -1,42044 -0,23856 -0,25095 -0,18258 0,212066 -0,01683 0,118256 -1,19994 -1,40431 -1,28162 0,022384 0,132671 reactome_Synthesis_of_bile_acids_and_bile_salts -0,10327 0,119523 0,055198 0,568108 -0,13272 -0,5945 -0,51092 -0,84912 -0,57653 1,232732 1,041507 0,026574 -0,34857 -0,56041 -0,31009 1,359054 -0,10457 0,476116 0,022403 0,132671 reactome_ABCA_transporters_in_lipid_homeosta -0,43719 -0,376 -0,29136 -0,2383 0,039721 -0,58538 -0,97393 -1,12607 -0,68143 0,782865 0,11627 0,629858 -0,07469 -0,35337 -0,34691 1,76779 1,407339 0,941528 0,022468 0,132805 reactome_Sphingolipid_de_novo_biosynthesis_M -0,004 -0,37431 -0,21986 -0,16335 1,21325 -0,1614 0,270239 0,53381 -0,21001 -0,59186 -0,22858 -0,97281 0,007784 -0,19046 0,479412 -4,02896 -3,7171 -1,4463 0,022656 0,133664 reactome_Cyclin_A_B1_associated_events_during 0,50241 -0,16819 -0,20853 0,586297 0,163002 -0,66179 0,894425 2,032129 0,213285 -3,10846 -2,92571 -2,01916 -0,40735 -0,39879 -0,72829 -7,52848 -4,55645 -3,58601 0,022773 0,134099 ATM_Pathway_Synaptic_Vesicle_Transport 0,026562 -0,07793 -0,09985 0,350871 0,689618 0,340865 -0,09767 0,083245 -0,24561 0,044175 0,24382 -0,02629 0,027761 -0,02649 0,026471 -0,74732 -0,60386 -0,30994 0,023014 0,135005 reactome_Sulfide_oxidation_to_sulfate_Main_Pa 0,016488 -0,03033 0,045345 -0,5561 0,003396 -0,13768 -0,00577 0,103815 -0,05918 -0,38092 0,207401 0,730311 -0,37318 -0,38865 -0,13638 0,160686 0,062454 -0,14311 0,023 0,135005 reactome_Repair_synthesis_for_gap_filling_by_D 0,335733 0,050385 0,144253 0,02798 0,803414 1,134415 3,267166 3,762054 2,878389 -0,86917 -1,31453 0,33836 -0,2063 0,102545 0,391793 -4,12863 -3,98581 -2,9432 0,023129 0,135175 reactome_Repair_synthesis_of_patch_27_30_bas 0,335733 0,050385 0,144253 0,02798 0,803414 1,134415 3,267166 3,762054 2,878389 -0,86917 -1,31453 0,33836 -0,2063 0,102545 0,391793 -4,12863 -3,98581 -2,9432 0,023129 0,135175 KEGG_Protein_export_Main_Pathway 0,577056 0,049329 0,056287 1,240589 1,21476 1,211989 -0,7042 0,149888 -1,71442 -4,31406 -0,14893 -0,23581 0,055081 -0,13955 0,080496 -9,16656 -7,63826 -5,9476 0,023211 0,135396 reactome_Nephrin_interactions_Main_Pathway -0,06285 0,013462 -0,13063 -0,00043 0,939897 0,527388 -1,95829 -1,69083 -2,49627 -0,43262 0,444974 0,273282 0,726829 0,412266 0,823578 -4,56672 -2,59556 -2,321 0,023263 0,135446 reactome_Cytosolic_sensors_of_pathogen_associ 0,25056 -0,07424 -0,36423 0,379562 0,107701 -0,81781 -0,41033 0,246497 -1,58658 -2,1945 -1,15661 -1,82715 0,06849 0,319438 0,145288 -8,00073 -6,31245 -5,22548 0,023348 0,135454 reactome_Polymerase_switching_Main_Pathway 0,54432 0,28412 0,285057 0,338348 1,019631 0,753729 3,065279 3,457548 2,237272 -2,25166 -1,98889 -0,64763 -0,40312 -0,44874 -0,19697 -5,36289 -4,39017 -3,24061 0,023473 0,135454 reactome_Polymerase_switching_on_the_C_stran 0,54432 0,28412 0,285057 0,338348 1,019631 0,753729 3,065279 3,457548 2,237272 -2,25166 -1,98889 -0,64763 -0,40312 -0,44874 -0,19697 -5,36289 -4,39017 -3,24061 0,023473 0,135454 reactome_Regulation_of_IGF_Activity_by_IGFBP_ -0,89304 -0,29224 -0,24452 -1,31486 -1,66011 -3,2906 -3,58693 -4,44306 -2,43291 0,12204 1,183643 -0,05718 -0,33186 -0,1491 0,265949 2,597629 2,2525 1,778911 0,023364 0,135454 Role_of_NTN1_in_Axon_Pathfinding -0,24027 -0,68617 -0,56826 1,140294 0,094366 1,265431 -2,58272 -2,10142 -3,79281 -3,95137 -0,1657 -2,69132 -1,59386 -1,12036 -0,04319 -10,5013 -7,65037 -5,6172 0,023482 0,135454 reactome_NrCAM_interactions_Main_Pathway 0,076145 -0,07491 0,045723 0,032941 -0,02198 0,557284 -1,93237 -1,80202 -2,20296 0,494089 -0,18196 -0,36256 0,557019 0,524892 0,680478 -0,95426 0,043262 0,183739 0,02357 0,135714 biocarta_il_3_signaling_Main_Pathway -0,28974 -0,5581 -0,33365 -0,48467 -0,51805 -0,01573 -0,26197 -0,39296 -0,30986 0,405449 0,051831 -0,16632 -0,22834 -0,93585 -0,6459 0,397481 0,526316 -0,04541 0,023661 0,135833 HIF1Alpha_Pathway_HIF1a_Degradation -0,0331 -0,01004 0,016009 -0,1486 -0,01893 -0,08579 -0,16465 -0,1423 -0,12675 0,06304 -0,03256 0,208771 -0,03163 0,082028 -0,03189 0,458169 0,500673 0,3287 0,023678 0,135833 AHR_Pathway_CYP1A1_CYP1B1_CYP1A2_AHRR_g -0,01277 -0,09123 -0,05909 0,056734 -0,16746 0,185202 -0,4263 -0,24477 -0,61337 -0,58049 -0,38962 -0,03605 -0,07847 -0,05399 0,163709 -1,82368 -1,20763 -1,40118 0,023832 0,136157 reactome_Phosphorylation_of_proteins_involved 0,095575 -0,05911 -0,01619 0,697653 1,126119 -0,07353 1,543418 1,698998 1,328322 -0,00627 0,384428 -0,30273 -0,06373 0,215121 0,208266 -1,89414 -1,83056 -1,3331 0,023829 0,136157 reactome_Phosphorylation_of_proteins_involved 0,077337 -0,17133 -0,0693 -0,00551 0,217193 -0,2462 0,285182 0,399018 0,193918 -1,37812 -0,80404 -1,31282 -0,04006 -0,08543 -0,31085 -1,19576 -0,64323 -0,12984 0,023866 0,136157 NCI_Ras_signaling_in_the_CD4_TCR_Main_Pathw -0,24981 -0,38397 -0,32721 -0,6399 -1,04347 -1,02596 -1,0641 -1,07355 -1,40884 -0,20617 0,553843 -0,53306 -0,5598 -0,26485 -0,12948 -0,40809 0,531429 0,572762 0,024057 0,136747 reactome_G_alpha_s_signalling_events_Main_Pa -2,83127 0,150676 1,296291 -1,77622 -3,05292 -3,3694 3,097697 0,159773 7,366904 5,989516 0,733135 0,647799 0,781574 0,059736 -1,50247 19,83066 15,50107 13,44149 0,024056 0,136747 biocarta_chromatin_remodeling_by_hswi_snf_atp -0,14125 -0,22867 -0,24305 0,078858 -0,28762 -0,20686 -0,09254 -0,00787 -0,32259 -0,91575 0,395286 0,470452 0,571595 0,666336 0,703112 -1,79838 -1,54113 -1,31132 0,025061 0,136958 biocarta_chromatin_remodeling_by_hswi_snf_atp -0,14125 -0,22867 -0,24305 0,078858 -0,28762 -0,20686 -0,09254 -0,00787 -0,32259 -0,91575 0,395286 0,470452 0,571595 0,666336 0,703112 -1,79838 -1,54113 -1,31132 0,025061 0,136958 biocarta_il_2_signaling_Main_Pathway -0,26006 0,106849 0,080827 -1,52365 0,023384 -1,29903 0,455024 -0,09368 0,711343 1,665108 0,597644 1,225451 -0,07433 -0,66713 -0,18013 -0,0544 -0,28176 -0,30224 0,024595 0,136958 dermatan_sulfate_biosynthesis_late_stages -0,04573 0,127329 0,179364 -1,23344 -0,54501 -0,69011 -0,17699 -0,27584 -0,34534 0,259406 0,195971 -0,00816 -0,03402 -0,41687 0,022885 0,170733 0,251816 -0,12541 0,024409 0,136958 KEGG_Cytokine_cytokine_receptor_interaction_M -0,97105 -0,05052 0,634897 -2,26301 0,679431 0,742606 2,301035 0,529991 3,23869 1,573333 1,397836 0,807492 -1,3155 0,011567 -0,43711 7,726306 6,533761 5,434467 0,024914 0,136958 KEGG_DNA_replication_Main_Pathway 0,98391 0,443379 0,44699 1,501175 1,435946 2,624909 7,90948 8,901416 6,567018 -3,63917 -2,2335 -2,28415 -1,43602 -0,88891 -0,46136 -11,0453 -8,87599 -7,18274 0,024637 0,136958 KEGG_Mismatch_repair_Main_Pathway 0,719218 0,271291 0,300779 1,369408 1,169121 1,449274 4,069369 4,937445 3,344305 -2,94021 -0,08999 -0,09888 -0,2008 0,173646 0,39544 -7,86204 -7,03365 -5,39299 0,025025 0,136958 NCI_FAS_CD95_signaling_Pathway_(cell_cycle) 0,021324 -0,04005 -0,00874 -0,06308 -0,06404 0,326995 -0,6304 -0,4668 -0,75581 -0,62216 -0,42353 -0,07418 -0,00611 -0,11292 -0,00123 -1,58568 -1,26046 -0,8305 0,024852 0,136958 NCI_S1P3_Main_Pathway -0,06187 -0,56675 -0,38706 0,481761 0,578621 0,01147 -1,96996 -1,84246 -2,12988 0,248021 0,142246 -1,06271 -0,31865 -0,38811 0,626396 -3,64914 -2,79783 -2,75128 0,025059 0,136958 RANK_Signaling_in_Osteoclasts_Pathway_Resorpt -0,57783 -0,38861 -0,56969 0,384456 -1,49336 0,729516 -0,59032 0,073858 -0,96512 0,289856 -1,50528 0,288686 0,309442 0,619669 1,344071 -3,68857 -3,07096 -2,06739 0,024498 0,136958 reactome_Amyloids_Main_Pathway -0,76783 -0,15127 -0,32488 -0,89615 -3,92561 -2,10077 3,60198 3,591853 4,05009 6,773837 2,702846 0,073576 -1,64661 -2,6111 -1,39444 -1,91125 -0,62786 -1,35381 0,024439 0,136958 reactome_Antigen_processing_Ubiquitination_Pro 3,05063 0,19069 -0,14405 -0,31826 1,332306 -2,63061 -8,71241 -6,17764 -17,4578 -16,0281 -6,67524 -9,80314 3,481237 2,913925 5,646549 -57,2924 -45,9569 -36,6646 0,024456 0,136958 reactome_CHL1_interactions_Main_Pathway -0,08188 0,064393 0,034781 -0,40681 -0,29039 -0,06853 -0,61964 -0,57499 -0,56658 1,790322 2,261346 2,171273 0,158634 0,172074 0,120672 0,169492 0,679721 0,488815 0,024797 0,136958 reactome_Formation_of_the_Early_Elongation_C 0,911781 -0,17126 -0,3986 0,982438 1,245762 0,356222 -1,23772 -0,21265 -2,42214 -2,7912 -1,85005 0,130046 -0,24417 -0,02664 0,007175 -8,65162 -7,73494 -5,84435 0,024781 0,136958 reactome_Formation_of_the_HIV_1_Early_Elonga 0,911781 -0,17126 -0,3986 0,982438 1,245762 0,356222 -1,23772 -0,21265 -2,42214 -2,7912 -1,85005 0,130046 -0,24417 -0,02664 0,007175 -8,65162 -7,73494 -5,84435 0,024781 0,136958 reactome_Netrin_mediated_repulsion_signals_M -0,27194 -0,32582 -0,19942 -0,70645 -0,25756 -0,09841 -2,24664 -2,32409 -2,10004 -1,24311 -0,47807 -0,99249 0,244479 0,152646 0,161772 -0,30893 -0,61097 -0,77233 0,024318 0,136958 reactome_temp_Immunoregulatory_interactions_ -3,21354 1,409367 1,363104 0,162511 3,892534 -0,55643 -0,05335 -4,92221 9,3031 10,1125 0,740128 6,876301 -1,34651 -2,7085 -1,84629 25,83129 17,80823 20,89311 0,024946 0,136958 reactome_Trafficking_of_GluR2_containing_AMPA 0,059086 -0,0938 -0,10929 -0,47424 -0,10473 0,326785 -0,43112 -0,66034 -0,50253 0,952162 0,542887 0,173574 -0,16797 -0,06273 0,14231 0,482074 0,716551 0,63467 0,02459 0,136958 reactome_Vasopressin_regulates_renal_water_ho -0,52715 -0,39556 -0,53622 1,633168 1,951159 -0,45862 -1,31598 -1,39187 -0,83848 -1,62976 0,718494 1,845855 0,401092 1,398684 1,667305 -1,83086 -1,83271 0,869321 0,024618 0,136958 reactome_VEGFA_VEGFR2_Pathway_Main_Pathw -0,15191 -0,98163 -1,3022 -0,69388 -0,165 -1,68301 -4,15539 -3,31781 -5,272 -0,87567 -1,6676 -1,15929 1,151971 0,461106 1,159662 -9,55306 -7,28616 -5,21957 0,024985 0,136958 Slit-Robo_Pathway -0,87972 -1,17126 -1,12141 0,641391 -2,50943 -1,23534 -5,19846 -5,20548 -5,49867 -7,93486 -2,89858 -1,68793 -0,60601 -1,52606 -0,61674 -10,6157 -7,21439 -5,61786 0,024633 0,136958 superpathway_of_melatonin_degradation -0,28365 -0,19193 0,019725 -1,39286 0,018703 -0,85895 0,032455 -0,26375 0,17956 -0,16881 -0,63445 0,75615 -0,67774 -0,23128 -0,00129 1,655241 1,419084 0,759084 0,024751 0,136958 BRCA1_Pathway_Mismatch_Repair 0,405282 0,042211 -0,0512 1,666261 1,180182 0,152898 1,521654 2,149143 0,62523 -1,00837 -0,36847 -1,20794 -0,48211 -0,27741 -0,41412 -4,51818 -3,0142 -2,9588 0,02568 0,140092 methylthiopropionate_biosynthesis 0,025579 -0,05885 -0,12156 0,042941 -0,3984 -0,09995 -0,00036 0,043338 -0,13088 -0,13478 -0,24598 -0,17474 0,280596 0,321454 0,20777 -0,85458 -0,85107 -0,8892 0,025744 0,140198 NAD_phosphorylation_and_dephosphorylation 0,024525 0,011893 0,043458 -0,11271 0,090737 0,044919 0,213049 0,21039 0,094082 -0,51565 -0,55955 -0,47893 0,073463 0,111189 -0,05317 -0,362 -0,0426 -0,05961 0,025929 0,140956 biocarta_sprouty_regulation_of_tyrosine_kinase_ 0,233167 0,207008 0,061219 0,175103 0,389988 0,511501 0,394483 0,340811 0,497701 1,114037 0,589268 0,122673 -0,06608 -0,05272 -0,3638 1,277051 1,159793 0,853307 0,026308 0,141535 BRCA1_Pathway 1,139772 -0,59178 -0,45494 2,506419 4,649848 1,275064 4,657666 6,463862 1,052229 -3,96589 0,556965 -2,17466 -1,04962 -0,08262 -0,41402 -17,4229 -12,366 -9,51938 0,026178 0,141535 ketolysis 0,118241 -0,11234 -0,08023 -0,10021 -0,38421 -0,12561 -0,7532 -0,53211 -1,01568 -1,02398 -0,21929 0,123734 0,306293 0,320077 0,490596 -1,4953 -1,23935 -1,07639 0,026185 0,141535 NCI_Nongenotropic_Androgen_signaling_Pathway -0,06005 -0,27993 -0,23695 0,934839 0,942695 -0,12351 -0,34503 -0,09647 -0,62596 -0,8916 0,685589 0,286319 0,122391 -0,08651 0,32369 -2,62929 -2,65312 -1,33572 0,026232 0,141535 reactome_Condensation_of_Prometaphase_Chro 0,166004 -0,01217 0,002321 0,393048 0,028846 0,095645 1,078766 1,293998 0,823542 -1,79571 -0,97084 -1,109 -0,49341 -0,3398 -0,40032 -2,55993 -2,05716 -0,91993 0,026276 0,141535 reactome_Regulated_proteolysis_of_p75NTR_Ma 0,221863 0,02652 -0,03203 0,051786 0,746862 -0,31746 -1,47562 -1,33053 -1,94993 -0,32164 0,148268 0,891708 1,05502 0,897442 1,109902 -1,83313 -0,84184 -1,23699 0,026253 0,141535 AHR_Pathway_PS2_Gene_expression_via_ESR1 0,270276 -0,00292 -0,05862 0,48024 0,266565 0,710747 -0,46859 0,009616 -0,99911 0,519611 -0,93092 -1,95031 0,142267 0,422466 -0,34752 -5,30961 -4,26948 -3,56191 0,026756 0,142509 glutamate_removal_from_folates 0,0484 0,023106 0,026637 -0,00265 0,048686 0,057682 0,608341 0,657028 0,456748 -0,21058 -0,13639 -0,17224 -0,00626 0,05556 -0,02918 -0,62181 -0,32079 -0,16592 0,026763 0,142509 NCI_Neurotrophic_factor_mediated_Trk_recepto 0,013046 -0,22403 -0,08138 0,464387 -0,18627 0,897696 -2,2962 -2,21043 -2,5479 -0,57984 -0,89301 -2,17442 -0,18257 -0,01892 -0,28137 -0,89667 -0,2512 -0,46815 0,026717 0,142509 reactome_HSF1_dependent_transactivation_Main -0,0716 -0,34072 -0,26301 0,278126 -0,03994 0,690889 -0,63437 -0,40913 -1,1979 0,1898 0,600171 -0,80445 0,302541 0,215604 0,124346 -1,75155 -1,61871 -0,14349 0,026595 0,142509 reactome_mRNA_decay_by_3_to_5_exoribonucle 0,228878 0,056872 -0,06959 0,76884 -0,13911 -0,05344 0,153889 0,266469 -0,39445 -1,57204 -0,51041 -0,78713 -0,03767 -0,28589 0,081799 -4,32629 -3,59304 -3,6501 0,026678 0,142509 reactome_RNA_Polymerase_III_Transcription_Init 0,080742 -0,3165 -0,63471 -0,07453 -0,40496 -1,0584 -0,69766 0,131723 -2,08102 -3,06614 -1,14772 -1,53238 0,14982 0,437965 0,372622 -9,58131 -7,97823 -6,59424 0,026541 0,142509 NCI_PAR1_mediated_thrombin_signaling_events_ -0,11229 -0,38798 -0,40883 -0,09781 0,049704 0,086902 -3,10029 -2,86304 -3,16627 -0,54052 0,84957 -0,56691 0,051119 0,269307 0,908348 -2,29071 -1,3773 -0,60808 0,02682 0,142567 biocarta_tumor_suppressor_arf_inhibits_ribosom -0,10127 -0,07435 -0,11541 0,12267 -0,35636 -0,11713 -0,09045 -0,10658 0,11695 -0,02471 0,229258 0,21649 -0,04612 -0,27064 -0,31545 0,263348 0,151773 0,12113 0,02689 0,142651 glutamate_biosynthesisdegradation -0,0512 -0,03093 -0,1623 -0,522 -0,51196 -0,36363 -0,0639 -0,00437 -0,1548 -0,66459 -0,36867 -0,39357 -0,45522 -0,49036 -0,34479 0,756623 0,766509 1,073307 0,026979 0,142651 NCI_IL6_mediated_signaling_events_Pathway_(M -0,00194 -0,12365 -0,1902 -0,29948 -0,37168 0,135323 -0,32206 -0,18388 -0,55004 -0,60315 -0,50224 0,110271 0,345695 0,460929 0,57262 -2,32881 -1,11777 -0,70414 0,027022 0,142651 reactome_Conversion_from_APC_C_Cdc20_to_AP 0,472535 -0,07023 -0,11325 -0,5154 -0,93144 -1,61848 0,427599 0,82897 -0,7435 -4,74316 -2,25978 -1,83804 -0,19998 0,279726 0,478121 -6,04516 -5,56614 -4,83777 0,027065 0,142651 reactome_Organic_anion_transport_Main_Pathw 0,070209 0,14573 0,200775 0,009552 -0,22105 0,114285 0,24445 -0,20771 0,712834 0,377317 0,516485 -0,68966 -0,33413 -0,14241 -0,20429 1,266629 1,04901 1,536639 0,027032 0,142651 reactome_GABA_A_rho_receptor_activation_Mai -0,06352 0,035494 0,188184 -0,35759 0,245868 -0,52148 -0,16245 -0,39794 0,009873 0,249455 0,670615 0,674182 0,145706 -0,55689 -0,53485 0,556859 -0,17009 -0,17217 0,027117 0,142686 NCI_PDGFR_alpha_signaling_Pathway_(JAK_STAT -0,06704 -0,09163 -0,08551 -1,71911 -1,76066 -1,49902 -2,48836 -2,40687 -2,6806 0,32782 -0,52239 0,016205 -0,10605 0,110941 -0,28764 0,6107 0,596535 1,074036 0,027224 0,143007 2-amino-3-carboxymuconate_semialdehyde_degr -0,07489 -0,06153 0,101233 -0,35969 -0,32794 -0,19969 0,153615 0,195887 0,252429 0,215016 -0,28588 -0,3208 -0,09774 -0,30328 -0,2744 -0,2714 0,357929 -0,02935 0,028266 0,14327 biocarta_b_cell_survival_Pathway_(apoptosis) 0,039807 -0,0154 -0,02531 0,177283 0,087987 -0,14153 -0,0868 0,014861 -0,18008 -0,88178 -0,52399 -0,42945 0,092424 0,004511 -0,11081 -0,27072 -0,32531 0,009207 0,029036 0,14327 biocarta_basic_mechanisms_of_sumoylation_Mai 0,244379 0,073048 0,029855 0,36518 0,215192 0,236514 0,272436 0,349359 0,197161 -0,3298 -0,20093 -0,02221 0,011434 0,298684 0,35339 -2,51569 -1,80121 -0,9899 0,028156 0,14327 biocarta_basic_mechanisms_of_sumoylation_Path 0,244379 0,073048 0,029855 0,36518 0,215192 0,236514 0,272436 0,349359 0,197161 -0,3298 -0,20093 -0,02221 0,011434 0,298684 0,35339 -2,51569 -1,80121 -0,9899 0,028156 0,14327 biocarta_cyclins_and_cell_cycle_regulation_Main_ 0,257961 -0,41038 -0,25301 2,042107 2,133069 -0,52969 1,347163 1,568048 0,81953 -1,30601 -0,60733 -0,40298 -0,01291 -0,28793 -0,82478 -6,72113 -6,14357 -4,85379 0,027844 0,14327 biocarta_role_of_U_00DF_arrestins_in_the_activa -0,65996 -0,15053 -0,03905 -1,60576 -0,77356 -1,29232 -2,48003 -3,18821 -1,56499 3,508812 2,659115 0,482218 0,260871 0,869641 0,861028 3,089347 1,399891 2,55727 0,027522 0,14327 biocarta_sumoylation_as_a_mechanism_to_modu 0,025563 -0,17203 -0,0681 0,102427 1,074983 0,740039 0,309326 0,347008 0,027797 0,420056 0,02526 -0,96125 -0,33702 -0,0408 0,224628 -2,51724 -2,31171 -1,053 0,028289 0,14327 glycerol_degradation 0,135511 0,067297 -0,03382 -0,23074 -0,16974 0,358368 -0,10631 0,267695 -0,481 -0,49832 -0,37007 -1,86397 -0,30713 -0,13573 0,115123 -1,89236 -1,76005 -1,51087 0,028633 0,14327 KEGG_mRNA_surveillance_Main_Pathway 0,523871 -0,20485 -0,1767 -0,59422 -2,32309 -0,09809 0,411011 1,069116 -0,708 -2,76016 -2,76371 -1,21931 1,000678 0,339752 1,209037 -7,17149 -5,9744 -4,5996 0,027715 0,14327 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(ac -0,11552 -0,04459 -0,09489 -0,50655 -0,12595 -0,20926 -0,31723 -0,34771 -0,3767 0,654492 0,332409 0,287082 0,036594 0,016623 0,021447 0,094467 0,084091 0,364251 0,027856 0,14327 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(a -0,1196 -0,06519 -0,06949 -0,31523 -0,18437 -0,25111 -0,08558 0,057503 -0,09893 -0,01605 -0,3721 -0,46444 0,360602 0,379895 0,314009 -0,98869 -0,80672 -0,74101 0,029024 0,14327 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(i -0,1196 -0,06519 -0,06949 -0,31523 -0,18437 -0,25111 -0,08558 0,057503 -0,09893 -0,01605 -0,3721 -0,46444 0,360602 0,379895 0,314009 -0,98869 -0,80672 -0,74101 0,029024 0,14327 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(n -0,1196 -0,06519 -0,06949 -0,31523 -0,18437 -0,25111 -0,08558 0,057503 -0,09893 -0,01605 -0,3721 -0,46444 0,360602 0,379895 0,314009 -0,98869 -0,80672 -0,74101 0,029024 0,14327 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(n -0,1196 -0,06519 -0,06949 -0,31523 -0,18437 -0,25111 -0,08558 0,057503 -0,09893 -0,01605 -0,3721 -0,46444 0,360602 0,379895 0,314009 -0,98869 -0,80672 -0,74101 0,029024 0,14327 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(n -0,1196 -0,06519 -0,06949 -0,31523 -0,18437 -0,25111 -0,08558 0,057503 -0,09893 -0,01605 -0,3721 -0,46444 0,360602 0,379895 0,314009 -0,98869 -0,80672 -0,74101 0,029024 0,14327 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(n -0,1196 -0,06519 -0,06949 -0,31523 -0,18437 -0,25111 -0,08558 0,057503 -0,09893 -0,01605 -0,3721 -0,46444 0,360602 0,379895 0,314009 -0,98869 -0,80672 -0,74101 0,029024 0,14327 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(p -0,1196 -0,06519 -0,06949 -0,31523 -0,18437 -0,25111 -0,08558 0,057503 -0,09893 -0,01605 -0,3721 -0,46444 0,360602 0,379895 0,314009 -0,98869 -0,80672 -0,74101 0,029024 0,14327 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(r -0,1196 -0,06519 -0,06949 -0,31523 -0,18437 -0,25111 -0,08558 0,057503 -0,09893 -0,01605 -0,3721 -0,46444 0,360602 0,379895 0,314009 -0,98869 -0,80672 -0,74101 0,029024 0,14327 NCI_Insulin_mediated_glucose_transport_Main_P 0,124015 -0,10802 -0,10596 0,177438 -0,30969 -1,4071 -1,1328 -0,93829 -1,30704 -2,73386 -1,03127 -1,39864 0,770529 0,191614 0,984398 -3,04513 -2,12146 -0,71872 0,02757 0,14327 NCI_LKB1_signaling_events_Pathway_(chromatin_ -0,04765 -0,05986 0,006185 -0,00072 0,161505 -0,03539 0,134204 0,155843 0,218066 0,021389 0,285733 0,362212 -0,24637 -0,09684 -0,08097 0,296296 0,497663 0,11184 0,028315 0,14327 NCI_RAC1_signaling_Pathway_(lamellipodium_ass 0,037407 -0,19156 -0,11999 -0,07238 -0,87367 -0,93385 -2,19362 -2,00138 -2,79736 -2,698 -0,62284 -1,12771 0,406603 0,485699 0,931657 -5,47203 -3,57059 -2,08457 0,028455 0,14327 NCI_RhoA_signaling_Main_Pathway 0,213321 -0,05922 -0,00764 1,56901 -0,01924 -1,16906 0,895317 1,180578 -0,03525 -1,34202 0,094758 -1,03218 1,145056 1,239872 1,34488 -2,54885 -0,71956 -0,6145 0,028912 0,14327 NCI_Validated_targets_of_C_MYC_transcriptional -0,00686 -0,11946 -0,14669 -0,32822 0,426733 0,141731 -0,53626 -0,54057 -0,73269 0,103509 -0,37715 0,234819 0,135729 0,115101 0,424389 -1,47063 -1,08936 -0,7415 0,029062 0,14327 reactome_Activation_of_BAD_and_translocation_ 0,049885 -0,09861 -0,10525 0,967602 1,641534 1,197518 -0,19293 -0,03194 -0,63104 -0,80933 0,120923 -0,60011 -0,11387 0,091615 -0,1813 -1,19306 -0,62487 0,078604 0,027822 0,14327 reactome_Activation_of_NIMA_Kinases_NEK9_NE 0,079492 0,008214 -0,07296 0,190916 0,355568 0,375726 -0,52325 -0,3331 -0,75419 0,366242 -0,97457 -0,70974 -0,37244 -0,16846 0,090096 -1,0623 -1,28724 -0,83582 0,028553 0,14327 reactome_AKT_phosphorylates_targets_in_the_c 0,153988 -0,20469 -0,12245 -0,28702 1,097188 0,000918 -0,58879 -0,46341 -1,15887 -0,11462 0,822854 -1,36371 0,353038 0,400952 0,068552 -2,12236 -2,26498 -1,75541 0,028732 0,14327 reactome_Apoptotic_cleavage_of_cellular_protei 0,184085 -0,09451 -0,02733 0,094038 0,177889 -0,31809 -1,3769 -1,23499 -1,99416 0,190847 -1,05004 -0,89581 0,050328 0,330994 0,185026 -2,16954 -1,8804 -0,59777 0,027947 0,14327 reactome_Chk1_Chk2_Cds1_mediated_inactivatio 0,184059 0,130016 0,063241 0,409357 0,827132 0,239207 1,197604 1,535808 0,855901 -1,23852 -1,39029 -1,25462 -0,53779 -0,45111 -0,39675 -2,30782 -1,12818 -0,97912 0,027893 0,14327 reactome_Digestion_of_dietary_lipid_Main_Pathw0,158324 -0,03896 0,078335 -0,58113 0,351648 0,117435 0,250687 -0,12613 0,373772 0,746227 0,170518 0,32097 0,064021 -0,12449 -0,1173 0,400385 0,837007 0,63592 0,028757 0,14327 reactome_ER_Quality_Control_Compartment_ER 0,166594 0,086705 -0,0212 0,255387 0,153523 0,41101 -0,79935 -0,4994 -1,16928 -1,08961 0,26607 -0,32501 0,018814 0,184554 0,030135 -2,89772 -2,21564 -2,33897 0,02884 0,14327 reactome_G_alpha_q_signalling_events_Main_Pa -3,33257 0,567427 0,602428 -1,89565 -1,83486 -3,241 -4,24879 -8,02586 1,916029 5,026533 1,185185 2,786882 0,378391 -1,01108 -0,93179 21,12901 20,71068 22,20085 0,027439 0,14327 reactome_Ligand_gated_ion_channel_transport_ -0,4927 -0,05794 0,31538 -0,78694 0,69113 -1,85242 0,431733 -0,04393 1,281184 1,848338 0,790759 0,626875 0,225822 -0,7544 -0,38449 1,304356 0,788096 0,6307 0,028805 0,14327 reactome_Loss_of_Nlp_from_mitotic_centrosome 1,456798 -0,08668 -0,22122 3,078252 2,067417 1,798826 0,982407 2,408618 -2,07197 -5,16235 -0,87826 -4,73259 -1,56501 -0,5671 -0,5179 -20,8349 -14,6702 -11,3576 0,027472 0,14327 reactome_Loss_of_proteins_required_for_interph 1,456798 -0,08668 -0,22122 3,078252 2,067417 1,798826 0,982407 2,408618 -2,07197 -5,16235 -0,87826 -4,73259 -1,56501 -0,5671 -0,5179 -20,8349 -14,6702 -11,3576 0,027472 0,14327 reactome_Processive_synthesis_on_the_C_strand 0,196332 0,065454 0,077095 0,128898 0,270626 0,270227 1,114897 1,165364 0,980358 -1,53159 -0,43398 -0,06882 0,050786 -0,13843 -0,13572 -0,70336 -0,91971 -0,72209 0,028526 0,14327 reactome_Role_of_DCC_in_regulating_apoptosis_ -0,03449 -0,21467 -0,07693 -1,1345 -0,29254 -0,25536 -1,10121 -1,00886 -1,1363 -1,59433 -0,99509 -1,70557 0,414931 0,420986 0,228904 -1,01319 -1,54566 -1,09793 0,029068 0,14327 reactome_SUMO_is_transferred_from_E1_to_E2_ 0,244379 0,073048 0,029855 0,36518 0,215192 0,236514 0,272436 0,349359 0,197161 -0,3298 -0,20093 -0,02221 0,011434 0,298684 0,35339 -2,51569 -1,80121 -0,9899 0,028156 0,14327 reactome_Viral_Messenger_RNA_Synthesis_Main 0,180059 -0,09488 -0,2229 0,559188 -0,5347 -0,18603 0,075849 0,462369 -0,42784 -2,35339 -1,40208 -0,19902 -0,29647 -0,16884 -0,015 -4,85121 -3,61279 -3,40843 0,028015 0,14327 superpathway_of_tryptophan_utilization -0,11602 -0,07818 0,357655 -4,40403 -0,65661 -1,62553 -2,36671 -3,4333 -1,63475 -0,31944 -1,4852 -0,55165 -0,11148 -0,47908 -1,11707 4,37298 4,598592 2,332599 0,028208 0,14327 biocarta_il_4_signaling_Main_Pathway 0,026096 0,362911 0,201697 -0,84377 0,247865 0,082096 -0,5856 -0,70963 0,016363 1,566868 1,218817 1,180922 0,464668 -0,43939 -0,10801 -0,11734 0,90437 0,064154 0,029138 0,14339 reactome_Signaling_by_FGFR_mutants_Main_Pat -0,66196 -0,41028 -0,48258 -0,90714 0,294968 -0,11651 -0,63445 -0,97756 -0,1952 -0,46856 -1,29719 -1,13923 -0,72702 -0,66365 -0,36148 -2,5313 -1,69445 -1,75291 0,02922 0,143565 reactome_Type_I_hemidesmosome_assembly_M -0,06451 0,02324 0,120335 -0,21729 -0,25711 -0,22205 -1,48643 -1,71806 -1,18071 0,031087 -0,13653 -0,60432 -0,21158 -0,08593 -0,55675 0,405551 0,229433 0,226336 0,029333 0,143892 NCI_N_cadherin_signaling_events_Pathway_(axon 0,078162 -0,01511 -0,0553 -0,05315 -0,12242 0,005388 -0,67113 -0,56808 -0,8418 -0,07367 0,637678 -0,47584 0,659628 0,693014 0,882421 -1,23747 -0,97274 -0,6804 0,029481 0,14432 reactome_ChREBP_activates_metabolic_gene_ex -0,15793 -0,09209 -0,12999 0,407896 0,171981 0,238291 -0,09226 -0,07608 0,053419 0,45096 0,210942 0,243579 0,268288 0,132877 0,164813 -0,01461 -0,20608 -0,18652 0,029513 0,14432 biocarta_thrombin_signaling_and_protease_activ 0,150201 -0,22292 -0,21111 -0,31172 -0,21673 -0,92806 -0,83799 -0,5091 -1,6239 -1,97522 -0,42847 -1,75136 -0,02556 0,085717 0,556101 -5,32979 -4,69905 -3,0553 0,029807 0,145529 NCI_Hypoxic_and_oxygen_homeostasis_regulatio 0,302387 0,089961 0,112613 -0,52529 0,091624 -0,66349 -0,23287 -0,10822 -1,19697 0,018402 -1,82119 -1,41014 0,48172 0,444849 0,87137 -4,37248 -3,44264 -2,53249 0,030057 0,146063 reactome_APC_C_Cdc20_mediated_degradation_ 0,630902 0,04917 0,102427 -0,71652 -1,21768 -1,85444 0,612119 1,095204 -0,89169 -5,65303 -3,63028 -3,21482 -0,60482 -0,07152 0,066557 -8,21219 -7,12497 -6,30307 0,030034 0,146063 reactome_Inactivation_of_APC_C_via_direct_inhi 0,630902 0,04917 0,102427 -0,71652 -1,21768 -1,85444 0,612119 1,095204 -0,89169 -5,65303 -3,63028 -3,21482 -0,60482 -0,07152 0,066557 -8,21219 -7,12497 -6,30307 0,030034 0,146063 PTEN_Pathway 0,714029 1,473616 1,878689 -2,17144 -3,63047 -1,80686 10,29532 11,73754 11,94796 -3,9408 -3,04957 -2,43131 -2,82086 -3,64467 -4,38272 18,11257 18,684 11,71539 0,030343 0,147224 reactome_PPARA_activates_gene_expression_Ma -0,04307 -0,2941 -0,25811 -0,51372 -0,78616 0,013763 0,438126 0,841945 -0,1843 -0,9451 -0,33033 -0,59525 0,321984 0,238246 1,389847 -3,85269 -2,6267 -1,75844 0,03039 0,147225 KEGG_Neuroactive_ligand_receptor_interaction_ -6,24498 0,414091 2,557524 -7,15271 -4,52634 -10,2622 -7,42151 -15,9298 6,78334 18,10035 5,39476 4,103077 5,82734 1,33884 3,823034 53,68357 48,36965 41,59832 0,030517 0,147612 reactome_ECM_proteoglycans_Main_Pathway -0,25833 -0,3482 -0,44218 -0,8401 -2,7133 -2,49224 0,842753 0,480873 1,129121 0,499511 -0,54947 -0,36075 -0,14553 -0,97401 0,381308 7,567575 7,37607 6,86525 0,030605 0,147807 Estrogen_Pathway_Gene_Expression_via_FOS_JU 0,755384 -1,24322 -0,92662 0,688338 1,492209 1,076688 -6,16244 -3,66471 -9,49141 -3,34457 -2,35826 -1,3631 0,150136 -0,15482 2,349156 -25,2655 -21,3704 -14,7265 0,030697 0,148021 CD16_Pathway_in_Natural_Killer_cells -0,02732 -0,49003 -0,45148 0,217909 -1,67541 -0,06771 -0,54216 -0,33815 -0,98502 -5,7879 -2,22193 -0,98319 -0,42887 -0,59495 -0,44905 -5,11282 -3,1544 -3,074 0,030885 0,148324 Lipoxins_Influence_on_Cell_Growth_and_Prolifer -0,28926 -0,37767 -0,41617 -0,87823 0,229991 -1,30971 -3,70161 -3,23065 -3,47191 -1,83638 -2,03113 -0,53352 -0,33658 0,718143 1,096202 -3,48148 -1,70717 -1,48638 0,030885 0,148324 reactome_Assembly_of_the_ORC_complex_at_th 0,484064 0,102181 0,040545 0,658521 0,507353 0,571978 -0,3108 0,026224 -0,86303 -1,09815 0,397227 -1,3217 -0,19338 0,11307 -0,26316 -2,36925 -1,91386 -0,74077 0,030903 0,148324 biocarta_actions_of_nitric_oxide_in_the_heart_M -0,05723 -0,32053 0,045663 -0,07183 0,992738 0,622832 -2,3495 -2,58611 -2,86258 1,305117 -1,15627 -0,29459 0,266509 0,395918 0,502441 -4,34676 -2,84872 -1,82474 0,031008 0,148601 KEGG_Pentose_phosphate_Main_Pathway 0,2059 -0,15925 0,408038 0,787867 0,34818 -0,60863 0,768393 1,228185 0,615971 -0,58976 -0,83943 -0,69044 0,293785 -0,38509 0,451726 -2,93287 -4,06046 -3,24109 0,031161 0,149103 Tumour_Infiltration_Pathway -3,79738 2,452422 2,115536 -6,60479 1,514998 0,766324 -0,64304 -5,60188 9,501274 3,429684 -1,79225 7,059493 -1,44705 -3,67495 -1,70009 34,82407 29,93556 24,4753 0,031293 0,149507 biocarta_hiv_1_nef_negative_effector_of_fas_and 0,081623 -0,21731 -0,00774 0,003474 -0,28774 -1,20843 -2,01483 -2,05136 -1,95333 0,861117 0,098518 1,58186 -0,38555 0,009615 -0,53966 -0,25126 0,320007 -0,1513 0,031356 0,149575 FGF2_Signaling_in_Epithelial-mesenchymal_trans 0,217593 -0,11205 -0,05117 0,677371 0,486593 0,471851 0,214679 0,325007 -0,47137 -0,68738 0,090694 -0,40001 -0,31094 -0,2258 -0,19788 -2,07897 -1,64106 -0,99887 0,031457 0,149828 reactome_Recruitment_of_mitotic_centrosome_p 1,732389 0,019912 -0,22395 3,176665 2,587565 2,730806 1,287658 2,8299 -2,22498 -3,81652 -0,00874 -3,09625 -1,62102 0,036037 0,340501 -21,4395 -16,5214 -11,7114 0,031691 0,150716 reactome_mRNA_decay_by_5_to_3_exoribonucle 0,551119 -0,20312 -0,15184 -0,04056 -0,17697 0,172651 -0,27499 0,052703 -1,03528 -1,44495 -0,23336 -0,37791 0,568919 0,282403 0,351381 -5,11298 -3,54704 -2,67045 0,031776 0,150889 KEGG_Protein_processing_in_endoplasmic_reticu 0,23788 0,237638 -0,16362 -0,66442 -0,41016 -1,10766 -3,1168 -2,73674 -3,748 -1,17869 -1,10119 -1,11775 1,44763 0,639638 0,964859 -5,20142 -4,78579 -3,3339 0,031855 0,151032 NCI_ATM_Pathway_(G2_M_transition_checkpoin 0,169068 -0,01198 -0,08087 1,087749 0,921587 1,011863 0,077773 0,209494 -0,40475 -1,02747 0,193981 -0,26062 -0,27251 -0,24343 -0,31469 -2,15389 -0,9253 -1,15096 0,031987 0,151174 NCI_Ceramide_signaling_Pathway_(ganglioside_b 0,008277 -0,32669 -0,18001 -1,25041 -0,96132 -1,4578 -0,9 -1,11099 -0,86722 -1,01592 -0,6145 1,516627 -0,77644 0,003369 -0,52975 0,082567 -0,03066 -0,08212 0,03203 0,151174 reactome_RNA_Polymerase_III_Transcription_Ter -0,03629 -0,43712 -0,7598 0,092219 -0,22887 -0,86337 0,4993 1,003931 -0,69747 -1,60721 -0,47941 -1,33665 0,128659 0,420716 0,324481 -8,9 -6,95548 -5,81431 0,031988 0,151174 Akt_Signaling_Pathway -10,838 -2,55463 -0,28974 -21,5847 -12,7753 -22,7742 -37,6166 -45,5935 -19,2073 26,0592 -4,2611 -2,04095 5,721482 1,655796 3,320058 61,60327 55,92625 49,39033 0,032144 0,151479 mTOR_Pathway_mRNA_Biogenesis 0,005129 -0,06534 -0,03449 0,372101 0,1095 -0,31557 -0,05677 0,071966 -0,22541 -0,24472 0,193855 -0,07511 0,108368 0,119084 0,336157 -0,76841 -0,46729 -0,61486 0,032253 0,151724 NCI_Ephrin_A_reverse_signaling_Pathway_(MAPK -0,09634 0,006563 -0,00205 -0,81255 -1,31278 -1,1534 -0,81315 -0,92684 -0,89254 0,948436 0,38704 1,021483 0,144478 0,39288 0,36205 0,493279 1,356226 0,800778 0,032342 0,151724 NCI_Ephrin_A_reverse_signaling_Pathway_(neuro -0,09634 0,006563 -0,00205 -0,81255 -1,31278 -1,1534 -0,81315 -0,92684 -0,89254 0,948436 0,38704 1,021483 0,144478 0,39288 0,36205 0,493279 1,356226 0,800778 0,032342 0,151724 AHR_Pathway_C-myc_expression_via_RELA 0,234816 -0,05011 -0,11469 0,311353 -0,0069 0,412592 -0,51006 -0,00427 -1,02 0,462475 -1,08819 -1,56449 0,17378 0,346193 -0,27174 -5,28205 -4,36774 -3,64509 0,032581 0,152389 reactome_FRS2_mediated_cascade_Main_Pathw -0,30077 -0,31103 -0,19874 -0,77556 0,338664 -0,05631 -0,62815 -0,8189 -0,17207 -0,98851 -0,56743 -0,57204 -0,33079 0,062503 -0,15434 -1,26808 -0,74918 -0,71298 0,032563 0,152389 KEGG_Chemokine_signaling_Main_Pathway -2,10481 0,089225 0,422491 -0,66339 4,638327 -0,16305 -2,58355 -5,53129 -1,00363 6,158995 4,290694 2,338311 -2,90519 -3,13718 0,005687 6,667982 8,317221 6,20243 0,032679 0,152397 NCI_Insulin_Pathway_Main_Pathway 0,110814 -0,60097 -0,7634 -0,91206 0,483151 -0,59553 -4,71318 -4,13203 -6,18655 0,82088 -0,92072 -0,51858 1,18825 1,278471 1,154462 -6,61213 -4,0563 -2,85294 0,032681 0,152397 reactome_Amino_acid_transport_across_the_pla -0,32127 0,178947 0,266661 -3,94783 -3,98412 -3,02546 -4,95722 -5,50325 -4,18166 0,536414 -0,93564 -0,07617 -0,21189 0,186543 -0,40145 1,715382 0,849689 1,567207 0,032836 0,152703 reactome_Platelet_Aggregation_Plug_Formation_ -0,20271 -0,1064 0,014098 -0,12174 -0,5657 0,083607 0,231209 -0,06694 0,804991 0,779307 0,471186 -0,04667 0,140327 -0,06661 0,146921 1,038211 0,841249 1,009957 0,032845 0,152703 reactome_Removal_of_the_Flap_Intermediate_M 0,442418 0,222251 0,203436 0,499163 1,013 1,030742 3,843263 4,336324 3,410474 -1,27188 -0,86884 -0,99777 -0,52188 -0,4551 -0,58391 -3,46883 -2,8651 -1,96316 0,032925 0,152849 Glucocorticoid_Receptor_Signaling_Pathway_Cell_ 0,193797 -0,51228 -0,32239 0,234275 -0,07014 -0,58887 -0,00558 0,330099 -0,71241 -2,68009 -0,24204 0,715611 0,080489 0,94163 0,672083 -5,51131 -3,97244 -2,32211 0,033274 0,15424 KEGG_Renin_angiotensin_system_Main_Pathway -0,06423 0,101888 -0,019 -1,71526 -1,60318 -0,47392 0,27578 -0,04659 0,898556 4,056633 1,298282 1,292501 -0,01794 0,12821 0,645815 1,32319 0,42364 -0,22306 0,033476 0,154943 androgen_biosynthesis -0,29956 0,006427 0,110968 0,315176 -0,34317 -0,32932 -0,09375 -0,19585 0,682245 1,403678 0,683938 -0,03608 -0,16006 -0,33601 0,496011 1,560599 1,525494 0,633415 0,034112 0,156246 biocarta_double_stranded_rna_induced_gene_ex 0,125285 0,188274 0,080188 0,066974 0,243892 0,124489 0,369648 0,362823 0,244549 -0,5919 -0,39349 -0,24674 -0,19753 0,026481 0,073125 -2,01364 -1,52803 -1,16749 0,034387 0,156246 GSK3_Signaling_Pathway_Protein_Synthesis 0,151765 0,30577 0,048102 -1,08986 0,006083 -0,688 -0,41622 -0,73037 -0,2861 1,574306 -0,43631 3,211932 -0,5459 0,126434 -0,11395 0,040712 -0,0713 0,872253 0,034307 0,156246 KEGG_Phagosome_Main_Pathway -0,0843 -0,55879 -0,07368 0,410036 -0,24958 -0,52773 -2,78941 -3,17064 -2,81869 -2,3308 -1,6616 -0,10237 -0,3881 -0,74716 -0,25457 -4,89496 -3,2743 -2,93273 0,034544 0,156246 NCI_ErbB2_ErbB3_signaling_events_Pathway_(ce -0,01469 0,007509 0,02971 -0,34508 -0,46923 -0,57387 0,287945 0,362184 0,275444 0,530251 0,230494 0,67319 -0,06869 0,007888 0,096837 -0,15064 -0,06263 -0,06694 0,034243 0,156246 NCI_p75_NTR_mediated_signaling_Pathway_(neu 0,082638 -0,03368 -0,1897 -0,56993 0,321952 0,215589 -2,21502 -1,57922 -2,81529 -0,29266 1,051187 -0,3295 1,345879 0,876188 1,37041 -5,38019 -3,13679 -4,37044 0,034506 0,156246 NCI_Syndecan_3_mediated_signaling_events_Ma 0,016528 -0,05529 -0,05834 0,028779 0,522692 -0,11752 1,112395 1,094584 0,826261 -0,90003 0,285229 -0,70152 0,047658 0,119409 0,06789 -1,48311 -0,11869 -0,43625 0,03427 0,156246 NCI_Trk_receptor_signaling_mediated_by_the_M 0,119832 -0,12495 -0,16996 -0,45797 -0,39609 0,076519 -0,51826 -0,16077 -0,92962 -1,34692 0,3968 -1,30712 0,136983 0,468747 0,407107 -1,53838 -0,99688 -0,7852 0,034072 0,156246 reactome_Abacavir_metabolism_Main_Pathway -0,0756 -0,10785 -0,0978 0,01448 0,299473 0,474182 0,404286 0,46648 0,272782 0,542412 -0,77165 0,657443 0,154528 0,479248 0,123712 -1,01287 -1,13418 -0,80936 0,034216 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KEGG_Cyanoamino_acid_metabolism_Main_Path 0,09777 0,079662 0,084878 -0,84545 -0,40031 -0,78035 0,588138 0,347157 0,837864 -0,33365 0,346171 0,501343 0,310537 -0,07834 0,152835 1,068605 0,533221 0,41144 0,034923 0,15675 NCI_IL23_mediated_signaling_events_Pathway_(p 0,081455 0,061066 -0,05082 -0,74599 -0,24183 -0,46566 0,13788 -0,05957 0,133325 -0,30456 -0,09693 0,408792 0,031323 0,017093 0,070131 0,716305 0,487772 0,484177 0,034913 0,15675 thiamin_salvage_III 0,001395 0,007149 -0,00941 -0,00894 -0,0582 -0,1401 0,181089 0,2689 0,103011 0,842285 0,18379 -0,25633 -0,15574 -0,12021 -0,28211 0,192733 0,386722 -0,02831 0,034834 0,15675 KEGG_Vascular_smooth_muscle_contraction_Ma -0,21093 -0,01294 -0,18112 0,411231 -0,40401 0,262048 -1,30665 -1,38203 -1,18864 -0,43412 -0,41086 -0,23673 0,312475 0,202752 0,359269 -0,05509 0,1845 -0,10231 0,035143 0,157285 reactome_Methionine_salvage_Main_Pathway 0,069014 -0,10697 -0,07538 0,203603 -0,75709 -0,10158 -0,62791 -0,32312 -0,70183 0,444372 -0,45599 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-0,58853 0,039678 0,168565 NCI_Visual_signal_transduction_Cones_Main_Pat -0,10122 0,045441 0,125061 0,500844 -0,20634 -0,21492 -0,36756 -0,16037 0,172236 1,281935 0,70068 1,615512 0,099763 -0,21117 0,046267 0,274931 0,920302 0,040651 0,03972 0,168565 S-adenosyl-L-methionine_biosynthesis 0,015097 0,025992 -0,0173 -0,06791 -0,02282 -0,0116 -0,24329 -0,04168 -0,19635 0,015984 -0,353 -0,43215 0,028223 -0,10484 -0,03342 -0,93892 -0,9468 -0,82309 0,039587 0,168565 retinoate_biosynthesis_II -0,08219 -0,07942 -0,08696 0,02645 -0,11688 0,352913 -0,19383 -0,27253 -0,27552 -0,48854 -0,17544 0,068973 0,130657 0,138294 0,212023 0,150264 0,157506 -0,37495 0,039862 0,168938 biocarta_b_cell_survival_Pathway_(cell_proliferat 0,008567 -0,03961 -0,01157 -0,03572 0,729537 0,124355 -0,10878 -0,12358 -0,31348 0,109153 0,289917 -0,02128 0,142838 0,135705 0,193266 -0,94325 -0,42698 -0,38877 0,040375 0,169483 ILK_Signaling_Pathway_Epithelial_Mesenchymal_ 0,783435 -0,01616 -0,05872 -0,75721 0,307349 0,722769 0,093719 0,363139 -0,61454 -1,36586 0,524862 -0,80658 1,656924 0,487821 0,033445 -5,85028 -5,48318 -3,16039 0,040272 0,169483 NCI_N_cadherin_signaling_events_Pathway_(regu -0,0122 -0,0583 -0,01166 0,522551 0,970841 0,241629 -1,01704 -1,03636 -1,30056 -0,14557 0,23225 -0,21508 -0,17539 -0,14768 -0,11297 -1,99375 -1,39851 -0,92328 0,040234 0,169483 reactome_Frs2_mediated_activation_Main_Pathw -0,06401 -0,13936 -0,13664 0,128566 0,27257 0,135125 -0,57315 -0,65524 -0,71077 -0,57974 0,176785 0,662944 0,220256 0,16257 0,250644 -1,95991 -1,38541 -0,77189 0,040137 0,169483 reactome_Leading_Strand_Synthesis_Main_Pathw 0,373475 0,250302 0,215449 0,334554 0,610565 0,551297 2,23435 2,408078 1,673767 -1,64739 -1,20631 -0,99605 -0,44206 -0,55668 -0,65378 -2,4787 -2,0647 -1,38684 0,040589 0,169483 reactome_NCAM_signaling_for_neurite_out_grow 0,130138 -0,10893 -0,20451 -1,064 0,105175 -0,19196 0,533264 0,832045 0,409072 -2,89636 -1,05592 -2,01481 0,113525 0,333045 0,040581 -1,45112 -0,99619 -0,39534 0,040509 0,169483 reactome_NoRC_negatively_regulates_rRNA_exp 1,105271 -0,33153 -0,86324 1,208168 1,439486 -1,65161 2,926903 4,636377 0,131488 -2,35281 -1,04541 -1,25097 0,553173 -0,22674 2,240203 -19,7866 -14,9458 -12,7795 0,040066 0,169483 reactome_Processive_synthesis_on_the_lagging_ 0,373475 0,250302 0,215449 0,334554 0,610565 0,551297 2,23435 2,408078 1,673767 -1,64739 -1,20631 -0,99605 -0,44206 -0,55668 -0,65378 -2,4787 -2,0647 -1,38684 0,040589 0,169483 reactome_Progressive_trimming_of_alpha_1_2_l 0,04367 -0,0098 -0,04945 0,286372 0,228541 0,076185 -0,88749 -0,85152 -0,79176 -0,09721 -0,07336 0,113191 0,083654 0,061845 -0,15121 -1,34636 -1,38624 -1,40401 0,040531 0,169483 reactome_Translocation_of_GLUT4_to_the_plasm 0,23843 -0,19097 -0,53532 -2,77056 -1,6693 -2,29283 -1,66657 -1,2538 -2,70558 -2,0026 -2,91388 -5,20179 0,634354 1,349528 1,64766 -12,7678 -10,0324 -7,68541 0,040241 0,169483 UDP-D-xylose_and_UDP-D-glucuronate_biosynthe 0,080718 -0,02705 -0,02511 -0,06104 -0,19477 -0,23387 -0,39075 -0,29388 -0,56628 -0,19385 -0,3279 -0,23017 0,090125 0,116917 0,235471 -0,81012 -0,58254 -0,48538 0,040583 0,169483 Inside-out_Signaling_through_Integrins -0,79206 -0,97305 -1,0318 0,657862 0,999633 0,037386 -0,33265 -0,71949 -0,77573 -1,99734 3,75815 -0,06908 0,561903 0,512073 1,449165 -3,96788 -3,82362 -1,59507 0,040759 0,169513 reactome_Mitochondrial_transcription_initiation_ 0,034751 -0,01584 -0,04643 0,000543 -0,09194 -0,00315 0,056627 0,201697 -0,05608 0,169127 -0,22122 0,282502 0,284716 0,254417 0,394414 -0,7337 -0,80702 -0,70144 0,040749 0,169513 reactome_Sperm_Oocyte_Membrane_Binding_M -0,04273 0,018015 0,039376 -0,03569 -0,2837 -0,30159 0,050907 -0,11898 0,154675 1,101509 0,137467 0,189589 -0,01931 -0,05878 0,162723 0,355481 -0,03972 0,297125 0,040667 0,169513 reactome_Activation_of_the_pre_replicative_com 0,894756 0,149506 0,508271 3,489377 2,02541 2,226539 7,263875 8,27552 5,336996 -1,5385 -1,00251 -1,9631 -1,73227 -0,65977 -1,02718 -8,72213 -6,33967 -4,13683 0,040878 0,169778 5-aminoimidazole_ribonucleotide_biosynthesis 0,088159 0,002834 -0,01113 0,309832 0,516685 0,492178 0,053917 0,134193 -0,05745 0,474361 -0,22556 -0,00687 0,055635 -0,10677 0,061817 -0,48852 -0,51634 -0,38087 0,041008 0,169865 RALB_Signaling 0,201297 0,037733 -0,03918 -0,03062 0,404657 0,016135 0,236796 0,345925 0,080961 -0,89828 -0,08621 -0,55612 -0,1343 -0,11674 0,123049 -0,63896 -0,27898 -0,29673 0,040986 0,169865 KEGG_RNA_degradation_Main_Pathway 1,269317 -0,2665 -0,61389 0,170468 -0,63388 -0,50867 -0,79711 0,723225 -4,00182 -7,25909 -1,03072 -2,32312 0,06337 0,442483 1,376145 -25,9205 -19,6151 -15,6509 0,041259 0,170461 reactome_Signaling_by_Hippo_Main_Pathway 0,127086 -0,37724 -0,01235 0,640616 0,369943 0,016112 0,100097 0,252467 -0,78117 -1,67195 0,34001 1,443494 0,223918 0,599293 0,577541 -3,27032 -3,59717 -1,90656 0,041261 0,170461 phenylethylamine_degradation_I -0,08197 0,08527 -0,01505 -0,04197 -0,0415 -0,22723 0,811745 0,616276 1,01638 -0,24385 0,817463 0,322854 -0,09304 0,072001 0,203012 0,616975 0,637772 0,54908 0,041423 0,170827 reactome_GRB2_events_in_ERBB2_signaling_Ma 0,024993 -0,07416 -0,09227 -0,36386 -0,02879 -0,13058 0,01874 0,06749 -0,16038 -0,8899 0,033104 -0,6137 -0,15686 0,063178 -0,05258 -1,29408 -0,95288 -0,99534 0,041459 0,170827 NCI_Signaling_events_mediated_by_Stem_cell_fa -0,02199 -0,14097 -0,11789 -0,17415 -0,54789 -0,86516 -0,52945 -0,37947 -0,62346 -0,31394 0,334403 0,644247 -0,21766 -0,3171 -0,14325 -0,29449 -0,32472 0,078437 0,041686 0,171433 tryptophan_degradation_X_mammalian_via_trypt 0,080779 0,056237 -0,00498 -0,46035 -0,42864 -0,20481 -0,74109 -0,72169 -0,61394 -0,68884 0,314554 -0,26129 0,211217 -0,34859 -0,23728 1,143258 1,084555 1,331307 0,041716 0,171433 biocarta_ifn_gamma_signaling_Main_Pathway 0,259547 0,105803 0,036014 -0,10149 0,056996 0,160673 0,4394 0,498059 0,122136 -0,19118 -0,40656 -0,49109 -0,00429 0,084553 0,260976 -1,70727 -1,07015 -0,40101 0,041886 0,171905 KEGG_Amino_sugar_and_nucleotide_sugar_meta 0,95688 0,452705 0,427922 -2,12591 0,047828 1,201974 -3,37701 -2,85028 -4,04968 -2,50376 -2,25403 0,077824 0,622389 0,954232 1,453934 -9,65881 -7,95616 -6,89289 0,042049 0,172154 NCI_AlphaE_beta7_integrin_cell_surface_interact 0,053725 -0,06631 0,191564 -0,59614 -0,10489 0,001277 -0,02494 -0,11951 0,20877 0,56653 -0,38114 0,919049 -0,12097 0,259338 0,249624 0,767273 1,152262 0,619606 0,042057 0,172154 NCI_ALK2_signaling_events_Main_Pathway -0,08614 -0,12968 -0,20178 0,20142 1,127071 -0,07079 -0,17074 -0,13689 -0,63944 -0,25163 0,19753 0,09732 0,176491 0,068362 -0,23104 -1,85267 -1,57391 -0,62676 0,042157 0,172333 reactome_Muscarinic_acetylcholine_receptors_M -0,03497 2,23E-05 0,0343 -0,64339 0,151015 -0,74551 -0,37328 -0,42672 -0,21015 1,24116 -0,11874 0,44412 0,468437 0,276134 0,157661 1,633841 1,441981 1,405207 0,042323 0,172785 biocarta_cdc25_and_chk1_regulatory_pathway_in 0,236752 -0,04614 0,009269 0,765273 0,729797 0,459191 0,994439 1,105066 0,769667 -0,41156 -0,15298 -0,42884 -0,22448 -0,26106 -0,20589 -1,16295 -0,85885 -0,51955 0,042525 0,173244 NCI_Aurora_A_signaling_Main_Pathway 0,189387 0,139583 -0,07108 0,040057 -1,23398 0,784521 1,928949 2,364378 1,325616 -4,10631 -3,19171 -2,74939 -0,7179 -0,06119 -0,8229 -3,84103 -1,35751 -1,24862 0,042546 0,173244 NCI_PDGFR_beta_signaling_Main_Pathway -0,60534 -0,88765 -1,10562 -0,32573 -0,34467 -1,8919 -4,05754 -3,34315 -5,9704 -2,95892 -1,23407 -2,84058 -0,74583 0,200989 0,653455 -8,64783 -4,33345 -0,61162 0,04285 0,174253 reactome_Integrin_cell_surface_interactions_Mai -0,80803 -0,46791 -0,04339 -2,16631 -2,60227 -4,21045 -3,53468 -4,71051 -2,50341 2,641663 0,083826 -0,45535 1,176671 0,014617 1,278583 6,418107 4,883282 4,40499 0,043 0,174634 NCI_BCR_signaling_Main_Pathway -0,01083 -0,23477 -0,42625 -0,204 0,994227 -0,57909 0,31484 0,760621 -0,22047 -1,95861 0,152945 -0,89593 0,569603 -1,16949 -0,06359 -4,47926 -3,58038 -2,2145 0,043074 0,174707 lipoate_biosynthesis_and_incorporation 0,100867 0,052454 -0,04364 -0,12794 -0,24009 -0,08676 -0,51984 -0,41333 -0,68677 -0,68164 -0,40306 -0,19874 -0,06539 0,030691 -0,02013 -0,89361 -0,80557 -0,93976 0,043176 0,174893 biocarta_proteasome_complex_Main_Pathway 0,994385 0,557487 0,490371 0,729651 0,90031 -0,0708 0,885106 1,199031 -0,13965 -3,38489 -0,04676 -1,21641 0,014057 0,306745 0,400287 -11,3428 -9,84552 -8,04896 0,043508 0,175325 biocarta_proteasome_complex_Pathway_(Pathwa 0,994385 0,557487 0,490371 0,729651 0,90031 -0,0708 0,885106 1,199031 -0,13965 -3,38489 -0,04676 -1,21641 0,014057 0,306745 0,400287 -11,3428 -9,84552 -8,04896 0,043508 0,175325 BRCA1_Pathway_Homologous_Recombination_Re 0,347826 0,078454 -0,05413 0,54466 1,077584 0,868157 1,363968 2,067186 0,338854 0,047111 -0,02239 0,299568 -0,25627 0,368951 0,311085 -4,94262 -2,52858 -2,4194 0,043434 0,175325 NCI_BARD1_signaling_events_Pathway_(DNA_rep 0,53369 0,183534 0,066534 0,828452 1,240774 1,154391 1,218996 1,6209 0,126984 -0,37365 -0,03843 -1,03062 -0,31535 -0,37614 -0,19196 -2,66285 -1,61421 -0,8447 0,043354 0,175325 NCI_Plasma_membrane_estrogen_receptor_signa -0,03282 -0,04566 -0,11736 -0,16982 0,802994 0,197193 0,146599 0,18996 0,145932 -0,23615 -0,50032 -0,46248 -0,2092 0,018341 -0,1072 -0,82418 -0,44858 -0,34175 0,043741 0,175811 reactome_Toll_Like_Receptor_9_TLR9_Cascade_M0,012429 -0,06361 -0,02847 0,120919 0,607733 0,709708 -0,59536 -0,47053 -0,90834 0,116766 0,530514 0,472019 0,151168 0,317585 0,043617 -1,35862 -1,59865 -1,28303 0,043703 0,175811 FGFR_Signaling 0,160438 -0,82687 -0,62511 -0,1707 0,614473 0,208287 -1,58402 -0,56215 -3,20932 -2,11264 1,609285 1,429032 1,061052 0,807812 1,622426 -7,91269 -4,17163 -3,31822 0,043906 0,176247 NCI_PDGFR_beta_signaling_Pathway_(actin_cytos -0,06814 -0,06056 -0,06342 -0,29895 0,185086 -0,07522 -0,47361 -0,43129 -0,60988 -0,16557 -0,07426 -0,02776 0,10762 0,027729 0,114772 -1,27062 -1,03201 -1,02472 0,043999 0,176394 Integrins_Signaling_in_Natural_Killer_Cells 0,190848 -0,11905 -0,2917 -1,64246 -2,78541 -2,76779 -3,68577 -3,86039 -3,26199 1,490709 1,019068 0,771136 0,332005 -0,27747 0,136713 -0,26354 -0,1742 0,801335 0,044425 0,177873 KEGG_alpha_Linolenic_acid_metabolism_Main_P -0,25407 -0,07173 -0,05644 -0,25361 -2,4245 -0,68303 -0,04262 -0,40375 1,307573 -0,63495 -1,41656 -1,21172 -1,20122 -0,66348 -1,18513 0,709002 2,383794 0,853803 0,044546 0,178125 biocarta__U_00DF_arrestins_in_gpcr_desensitizat -0,73301 -0,12375 0,030673 -1,47968 -0,47232 -0,40465 -2,22695 -2,98529 -1,14236 4,265089 3,311224 0,689419 0,532905 1,210223 1,168528 3,659184 2,053911 2,719595 0,044892 0,178547 D-imyoi-inositol_1456-tetrakisphosphate_biosynth -0,08414 -0,06775 -0,07119 -0,08176 0,205318 0,04812 0,030534 0,052567 0,178893 0,322314 0,014981 -0,24513 0,093381 0,161793 0,038153 -0,66006 -0,29293 -0,20159 0,044791 0,178547 Erythropoietin_Pathway -1,58128 -1,65805 -1,74558 0,457594 -1,4644 -2,98191 -4,95223 -4,27851 -6,07857 -4,82873 -0,60047 0,75233 1,013466 -0,94288 1,957373 -19,1281 -14,4377 -11,3237 0,044835 0,178547 NCI_IL27_mediated_signaling_events_Pathway_(p -0,01646 -0,14583 -0,08516 -0,48479 -0,27911 -0,77453 -0,61741 -0,63076 -0,79257 1,877922 0,897588 0,948258 -0,51746 0,051631 0,067773 -0,70135 0,097439 0,126439 0,044726 0,178547 reactome_Acyl_chain_remodeling_of_DAG_and_T -0,17112 -0,22946 -0,09725 -0,77177 -0,87609 0,005956 -0,85211 -0,8527 -0,90493 0,025442 -0,07099 0,227224 -0,16862 -0,20878 -0,00662 0,567135 0,141726 0,45256 0,044938 0,178547 biocarta_akt_signaling_Pathway_(Pathway_prote 0,057495 -0,07455 -0,06914 0,403803 0,918792 0,868008 -0,06366 -0,13074 -0,30896 -0,05975 0,195992 -0,27483 0,154164 -0,00224 0,07211 -0,12211 -0,08766 0,130759 0,045231 0,178749 KEGG_D_Glutamine_and_D_glutamate_metabolis -0,15116 0,032408 -0,0365 -0,15377 0,040707 -0,1979 -0,21937 -0,18048 -0,25018 -0,06364 -0,05766 -0,40854 0,185064 0,076761 0,118579 -1,35569 -0,59371 -0,52301 0,045296 0,178749 KEGG_Proximal_tubule_bicarbonate_reclamation -0,15116 0,032408 -0,0365 -0,15377 0,040707 -0,1979 -0,21937 -0,18048 -0,25018 -0,06364 -0,05766 -0,40854 0,185064 0,076761 0,118579 -1,35569 -0,59371 -0,52301 0,045296 0,178749 NCI_Netrin_mediated_signaling_events_Pathway_ -0,05442 -0,14422 -0,17698 -1,09068 -0,90072 -1,01956 -1,1609 -1,11686 -1,30941 -1,76147 -0,92474 -1,24157 0,737142 0,721796 0,785262 -2,58396 -2,54146 -2,32402 0,045333 0,178749 purine_deoxyribonucleosides_degradation -0,01168 -0,02681 -0,03171 -0,00672 -0,2568 0,182295 0,57846 0,647887 0,610253 -0,21157 -0,13967 -0,60615 0,23905 0,137233 0,034955 -0,17458 -0,22322 -0,0227 0,045088 0,178749 reactome_Orc1_removal_from_chromatin_Main_ 2,718841 0,836453 0,80894 2,444908 2,348738 -1,56021 3,699343 4,654428 -0,24753 -6,36119 0,098319 -2,21964 0,81561 1,6197 1,476888 -28,5882 -22,9818 -18,1738 0,045215 0,178749 NCI_Signaling_events_mediated_by_PRL_Main_P 0,170193 -0,09802 -0,12094 1,462454 1,07699 -0,66209 0,172282 0,540965 -0,15659 0,00214 -0,49146 -0,64499 -0,28274 0,006301 -0,41822 -4,61722 -4,25675 -3,00134 0,045739 0,17899 phytol_degradation 0,069804 -0,01735 -0,02019 0,213462 0,14781 0,314892 -0,67311 -0,60893 -0,79958 -0,02197 0,491485 0,32116 0,184066 0,174166 0,260225 -0,63533 -0,65931 -0,50969 0,045506 0,17899 reactome_Beta_oxidation_of_myristoyl_CoA_to_ 0,056981 0,086345 -0,02253 -0,31498 -0,09333 0,296278 0,215545 0,154902 0,012122 0,121978 -0,33346 0,01932 0,265154 0,206957 0,322971 -1,45866 -0,96394 -1,04832 0,045704 0,17899 reactome_Nicotinamide_salvaging_Main_Pathway 0,013015 0,114222 -0,05007 -1,45626 -0,42564 -0,95335 -0,79083 -0,88795 -0,70774 0,704171 1,250545 1,007958 0,370994 -0,02205 0,469593 0,385216 0,41756 0,577093 0,045715 0,17899 reactome_Toll_Like_Receptor_TLR6_TLR2_Cascad 0,180261 0,03468 0,147643 -0,15544 -0,15166 -0,11039 -0,21121 -0,22296 -0,01788 0,408653 0,695801 0,128401 -0,04858 -0,69304 0,078743 0,25174 -0,25812 -0,24657 0,045658 0,17899 urea_cycle -0,19723 -0,15169 -0,06524 -0,15348 -0,55109 0,11458 0,03823 -0,27841 0,095104 0,722412 -0,27809 0,075694 -0,16028 -0,04966 -0,27405 1,18853 0,262091 1,168968 0,045562 0,17899 Erythropoietin_Pathway_Cell_Survival -0,78914 -0,90687 -1,19135 1,321163 -0,0202 -0,74441 -2,63625 -2,07346 -3,71256 -2,79682 0,265592 3,475578 0,801345 -0,15659 1,690914 -8,14774 -6,11131 -5,73543 0,045928 0,179503 biocarta_role_of_parkin_in_ubiquitin_proteasom 0,064666 -0,04578 -0,03716 -0,34065 0,192401 -0,17061 -1,83182 -1,70025 -2,10782 -0,63532 -1,10399 -0,03893 0,082057 -0,01348 -0,15585 -1,8632 -1,7161 -0,59974 0,046317 0,180799 biocarta_b_cell_survival_Main_Pathway 0,055584 -0,02718 -0,07503 -0,28372 0,962923 -0,38864 0,058525 0,220037 -0,22735 -1,32634 0,009476 -0,34669 0,228642 0,339213 0,320594 -1,28956 -0,69126 0,002704 0,046988 0,182958 fatty_acid_elongation_--_saturated 0,017158 -0,03114 -0,03534 0,23314 0,101395 0,088119 -0,33095 -0,34302 -0,49785 0,283323 0,104696 -0,66382 0,055823 -0,07209 0,074628 -0,76517 -0,51 -0,30691 0,046972 0,182958 biocarta_cdk_regulation_of_dna_replication_Mai 0,958751 0,275789 0,347547 2,78513 1,886353 0,65651 3,599251 4,04907 2,350774 -0,45898 0,958009 -1,40712 -0,48419 -0,10184 -0,20134 -5,4098 -4,50856 -3,00778 0,047078 0,183076 MAPK_Family_Pathway_Chromatin_Remodelling -0,03853 -0,48632 -0,23989 0,391616 0,149673 -0,80053 1,557825 1,68926 0,76091 -0,15346 0,802697 -0,86426 0,530454 -0,23717 1,758413 -2,68619 -1,99124 -1,76371 0,047253 0,183076 NCI_Downstream_signaling_in_naive_CD8_T_cells 0,079627 0,434792 0,184254 0,073953 0,049859 0,238605 0,294997 0,029208 0,858338 1,235843 0,656252 0,028832 -0,23629 -0,45093 0,02476 0,222499 -0,08176 0,137392 0,047244 0,183076 reactome_APC_Cdc20_mediated_degradation_of_ 0,796039 0,013546 0,149749 -1,24056 -1,60029 -2,37711 1,273635 1,827475 -0,39657 -6,26907 -3,79459 -3,06555 -0,70111 -0,23134 -0,07106 -10,538 -8,83356 -7,56986 0,047156 0,183076 KEGG_GABAergic_synapse_Main_Pathway 0,588687 -0,14382 -0,17213 2,537146 2,496208 2,717257 2,511783 2,221424 1,297946 -1,38789 1,06422 0,391675 -0,46072 -1,3456 -0,81373 -7,50928 -7,75755 -6,32902 0,047396 0,183401 reactome_CREB_phosphorylation_through_the_a -0,01013 -0,15841 -0,03459 0,307995 0,229639 -0,10161 -0,01414 0,009583 -0,12568 -1,03167 -0,2021 -0,96416 -0,08626 -0,3079 -0,19027 -0,3554 -0,28655 -0,30899 0,047577 0,183872 D-mannose_degradation 0,028283 0,014698 -0,02948 0,32275 0,180183 0,075112 0,193521 0,183881 0,124692 -0,27064 0,02161 -0,0821 -0,09306 0,084832 0,098172 0,157428 -0,17471 -0,07259 0,047779 0,184006 lactose_degradation_III 0,006441 0,049182 0,018555 -0,05965 0,119935 0,072437 -0,35776 -0,34657 -0,38299 -0,26873 -0,03713 0,096674 0,024255 0,038491 -0,0132 -0,40458 -0,28933 -0,20588 0,047766 0,184006 Mitosis_Initiation 0,863659 0,30024 0,09454 0,544499 0,464415 -0,87896 -0,96177 -0,1306 -2,54674 -2,51545 -0,84028 -0,85723 -0,1531 0,124966 0,328118 -9,32116 -6,91735 -6,72384 0,047788 0,184006 BRCA1_Pathway_Chromatin_Remodeling 0,015429 -0,67376 -0,50081 0,35496 0,439432 -0,29813 0,404316 1,045825 -0,8407 -1,6277 0,351118 -0,26634 -0,2747 -0,13662 -0,07542 -6,63301 -3,85623 -2,94047 0,047878 0,184122 biocarta_role_of_mef2d_in_t_cell_apoptosis_Path 0,028251 0,09714 0,080988 -0,05505 0,209494 0,39176 0,182359 0,248713 0,217232 0,521713 -0,23894 0,700566 -0,41351 -0,15873 -0,26476 0,800802 0,470775 0,438175 0,048309 0,18516 reactome_NRIF_signals_cell_death_from_the_nu 0,379068 0,003458 0,125187 -0,03425 0,780259 0,06094 -0,31562 -0,17022 -0,71842 -0,36516 0,760041 0,489737 0,853336 0,665163 0,855376 -4,76548 -3,0147 -2,97728 0,048253 0,18516 reactome_Synthesis_of_bile_acids_and_bile_salts -0,3965 -0,10623 0,081555 -1,78362 -0,12684 -1,49698 -2,03543 -2,66465 -1,48335 0,596581 1,074844 0,298636 0,531509 -0,02717 0,635028 2,757975 1,542605 1,490107 0,048326 0,18516 biocarta_overview_of_telomerase_rna_compone -0,04039 -0,14025 -0,05504 -0,61082 -0,18595 -0,15837 0,369655 0,4537 0,03313 -0,78839 -0,23791 -0,55981 -0,16295 0,210026 0,15818 -2,41239 -1,64477 -1,27779 0,048463 0,185279 reactome_Reuptake_of_GABA_Main_Pathway 0,037342 -0,13282 0,034189 -0,05521 0,506949 0,54682 0,737466 0,909052 1,082002 0,160269 0,666861 0,335621 -0,61264 -0,43533 -0,47158 1,450755 0,966413 1,466082 0,048476 0,185279 reactome_PI3K_AKT_activation_Main_Pathway -0,20503 -0,17615 -0,18233 0,018283 0,100722 0,173602 -0,6251 -0,68443 -0,65304 0,567617 -0,07678 0,343851 0,277775 0,202511 0,364016 -1,81111 -1,18139 -0,86468 0,048649 0,185487 selenocysteine_biosynthesis 0,070497 0,034534 0,04111 0,10164 0,094118 0,461365 0,357082 0,154047 0,203614 -1,01127 -0,07664 0,124525 -0,15803 -0,14622 -0,17247 -1,03579 -1,24748 -1,16608 0,048609 0,185487 NCI_IL8_and_CXCR2_mediated_signaling_events_ -0,14915 -0,19695 0,053709 -0,40115 0,014656 -1,67357 0,02537 0,120258 0,27657 1,010931 -0,41285 -0,33509 -0,27442 -0,20009 0,218828 1,355805 1,125403 1,679976 0,048736 0,185487 reactome_Cdc20_Phospho_APC_C_mediated_deg 2,508175 0,66025 0,696199 -0,95489 -0,9625 -4,41919 1,396762 2,425627 -2,77682 -10,7198 -4,0114 -4,34255 0,367136 1,235491 1,50444 -31,1687 -25,5403 -21,463 0,048769 0,185487 biocarta_skeletal_muscle_hypertrophy_is_regulat 0,376334 0,139285 0,054088 0,653232 1,039627 -0,10119 0,038977 0,2304 -0,62602 0,397161 -0,13056 0,471981 0,092049 0,333881 0,736506 -3,15803 -2,13772 -1,32719 0,048863 0,185621 ERK_Signaling_Pathway_Gene_Expression_via_CA -0,19594 -1,14652 -1,03098 -1,88939 -0,59481 -1,40523 -0,78846 -0,14011 -2,33359 -2,0045 0,989576 -2,35287 0,651855 -0,42049 1,485778 -7,94933 -8,03741 -6,63279 0,049354 0,186254 ILK_Signaling_Pathway_Epithelial_Mesenchymal_ -2,53579 -1,07505 -0,39974 -9,11997 -5,90081 -6,67794 -13,0138 -14,1705 -8,87968 4,042289 -1,90367 2,195255 2,566612 0,97965 1,291945 10,59912 8,801721 7,10822 0,049205 0,186254 ILK_Signaling_Pathway_Migration_Vasculogenesis -2,53579 -1,07505 -0,39974 -9,11997 -5,90081 -6,67794 -13,0138 -14,1705 -8,87968 4,042289 -1,90367 2,195255 2,566612 0,97965 1,291945 10,59912 8,801721 7,10822 0,049205 0,186254 NCI_Arf6_trafficking_events_Pathway_(endocytos 0,002915 -0,20113 -0,12241 -0,11067 -0,72712 0,19796 -0,96319 -0,95961 -0,91937 -0,61246 -1,19126 -1,15103 0,325556 0,231003 0,105138 -0,34605 -0,16698 -0,41512 0,049571 0,186254 NCI_IL23_mediated_signaling_events_Pathway_(k 0,017057 0,036371 0,004857 -1,12856 -0,31191 -0,33541 0,240195 0,130468 0,358989 -0,74573 -0,57923 0,377782 -0,37171 -0,18877 0,130471 1,033903 1,062718 0,988162 0,049633 0,186254 NCI_IL23_mediated_signaling_events_Pathway_(p 0,017057 0,036371 0,004857 -1,12856 -0,31191 -0,33541 0,240195 0,130468 0,358989 -0,74573 -0,57923 0,377782 -0,37171 -0,18877 0,130471 1,033903 1,062718 0,988162 0,049633 0,186254 NCI_IL23_mediated_signaling_events_Pathway_(p 0,017057 0,036371 0,004857 -1,12856 -0,31191 -0,33541 0,240195 0,130468 0,358989 -0,74573 -0,57923 0,377782 -0,37171 -0,18877 0,130471 1,033903 1,062718 0,988162 0,049633 0,186254 NCI_IL23_mediated_signaling_events_Pathway_(p 0,017057 0,036371 0,004857 -1,12856 -0,31191 -0,33541 0,240195 0,130468 0,358989 -0,74573 -0,57923 0,377782 -0,37171 -0,18877 0,130471 1,033903 1,062718 0,988162 0,049633 0,186254 NCI_IL23_mediated_signaling_events_Pathway_(T 0,017057 0,036371 0,004857 -1,12856 -0,31191 -0,33541 0,240195 0,130468 0,358989 -0,74573 -0,57923 0,377782 -0,37171 -0,18877 0,130471 1,033903 1,062718 0,988162 0,049633 0,186254 NCI_Validated_transcriptional_targets_of_TAp63_ 0,238137 0,046146 0,286891 -0,293 -0,44335 -0,3152 -1,37493 -1,17434 -1,35431 0,796228 0,62671 -0,17378 0,132119 0,4424 0,532334 0,823752 0,866448 0,904289 0,049527 0,186254 reactome_PD_1_signaling_Main_Pathway -0,83618 0,561686 0,027327 -0,06904 -0,16834 1,1308 -0,11314 -0,97945 1,454987 0,60883 1,693673 1,794912 0,395377 0,147228 0,292883 4,950888 4,055507 4,767136 0,049688 0,186254 NCI_PLK1_signaling_events_Pathway_(G2_M_tran 0,094348 0,032238 -0,03071 -0,36891 -0,30881 -0,33851 1,20109 1,354293 0,905614 -1,55428 -1,82717 -0,92971 -0,26706 -0,25736 -0,28192 -1,80316 -1,08811 -0,97315 0,049782 0,186382 PTEN_Pathway_Adhesion_or_Migration 1,281796 0,990489 0,982687 -1,59468 0,089054 4,404653 10,96441 11,62888 10,87152 -6,32961 1,134413 4,135421 -2,52894 -3,04639 -4,74098 13,00696 15,45994 11,0645 0,04994 0,186751 KEGG_Basal_transcription_factors_Main_Pathway 1,279395 0,044055 0,121659 2,486901 1,511264 0,53309 -0,13435 1,338864 -2,42747 -0,97929 0,489995 0,659892 0,507057 0,332072 1,508112 -16,5107 -12,6466 -9,70489 0,050115 0,187182 ATM_Pathway_Apoptosis_and_Senescence 0,039989 -0,12746 -0,18471 0,665071 0,384844 0,240545 -0,05772 0,204134 -0,4567 0,317173 -0,02866 0,177343 0,064733 -0,14546 0,070778 -0,95668 -0,08267 -0,72991 0,050447 0,188195 serotonin_degradation 0,075217 -0,16864 0,098826 -1,73311 -0,6027 -1,30038 1,005824 1,006445 1,158058 0,56622 0,121762 1,131836 -0,22211 0,226523 -0,14031 -0,01147 0,179722 -0,5021 0,05075 0,189052 UDP-iNi-acetyl-D-galactosamine_biosynthesis_I 0,036613 0,030115 0,059557 0,121202 0,159693 0,268994 0,179422 0,096469 0,192161 -0,01048 -0,35028 -0,50202 0,077695 -0,04825 0,233805 0,029073 0,232837 -0,02991 0,050798 0,189052 Glucocorticoid_Receptor_Signaling_Pathway_Gen 0,40858 -0,44499 -0,03022 -0,40968 0,500132 -0,42788 0,128612 0,616811 -0,60741 -2,36607 -0,13147 0,861136 0,308907 0,404916 0,694109 -5,95996 -3,95413 -2,88905 0,051043 0,189738 biocarta_ras_independent_pathway_in_nk_cell_m 0,107657 -0,0639 0,08693 -0,20722 -0,43204 -0,23915 -0,59957 -0,48794 -0,75241 0,009897 0,446979 0,219004 0,222401 0,347864 0,266135 1,011777 1,407883 1,737157 0,051521 0,19015 choline_degradation 0,041723 -0,00701 0,018599 -0,32515 -0,38288 -0,32695 -0,01645 0,067534 -0,08588 0,677112 0,64487 0,37063 0,051853 0,046206 -0,08828 -0,36135 -0,27767 0,190192 0,051311 0,19015 NCI_Downstream_signaling_in_naive_CD8_T_cells -0,54312 -0,13526 -0,51982 0,055035 0,2512 -1,52867 -1,17766 -1,6355 -0,97875 1,450695 2,113556 1,534294 -1,17125 -1,34444 0,195122 0,128618 -0,52974 0,558185 0,051407 0,19015 NCI_Signaling_events_mediated_by_PRL_Pathway 0,00981 0,026437 0,010799 0,812519 0,59674 0,375952 -0,77098 -0,67332 -0,98587 0,024855 0,262777 -0,19697 -0,23183 -0,19981 -0,1227 -1,56824 -1,69306 -1,08852 0,051439 0,19015 reactome_Cohesin_Loading_onto_Chromatin_Ma 0,284142 -0,0044 -0,06346 0,825838 0,510342 0,559374 1,017924 1,310548 0,285414 -0,77113 0,263749 -0,42953 -0,51758 0,039285 -0,15581 -2,88892 -1,86476 -0,6102 0,051259 0,19015 reactome_Ethanol_oxidation_Main_Pathway 0,041602 0,043101 0,033937 -0,43171 -0,24886 -0,48081 1,073155 1,146044 1,180341 0,368919 -0,3257 0,459029 0,104002 0,245872 0,236158 1,54158 0,478724 0,997339 0,051486 0,19015 biocarta_role_of_egf_receptor_transactivation_by 0,1466 -0,07249 -0,00353 -0,21854 -0,41236 -0,2485 -0,18529 -0,10159 -0,25505 0,536475 -0,08454 -0,72952 -0,05408 -0,25095 0,025891 0,726869 0,479431 0,431013 0,051907 0,190897 biocarta_trefoil_factors_initiate_mucosal_healing 0,1466 -0,07249 -0,00353 -0,21854 -0,41236 -0,2485 -0,18529 -0,10159 -0,25505 0,536475 -0,08454 -0,72952 -0,05408 -0,25095 0,025891 0,726869 0,479431 0,431013 0,051907 0,190897 superpathway_of_choline_degradation_to_L-serin -0,02683 0,137112 -0,02873 -2,13181 -1,96075 -1,40365 0,426749 0,436428 0,455013 1,108681 1,25976 0,705047 0,45843 0,106355 0,078441 0,353531 -0,08732 0,079533 0,051894 0,190897 NCI_RXR_and_RAR_heterodimerization_with_oth -0,52962 -0,15106 -0,42927 -1,24724 -0,3726 -0,35627 -1,24681 -1,39974 -1,01785 -0,54315 0,619742 0,423094 -0,29863 -0,19871 0,139023 0,841888 1,239813 0,583594 0,052306 0,192138 IGF1R_Signaling_Pathway -0,12018 -1,31183 -1,37706 2,082327 2,64459 -1,02345 -13,1607 -12,2455 -15,3071 0,105618 3,31428 2,859398 1,673124 0,829689 4,4131 -13,3592 -8,52011 -4,06463 0,052419 0,192325 biocarta_sprouty_regulation_of_tyrosine_kinase_ 0,118085 -0,16959 -0,24925 -0,29915 -0,35251 -0,76725 -0,3991 -0,21505 -0,45476 -0,38056 1,039954 0,795688 -0,3484 -0,77006 -0,56697 -0,90983 -0,11445 -0,43545 0,05261 0,192746 NCI_PDGF_receptor_signaling_network_Main_Pa -0,06439 -0,13261 -0,06189 -1,28497 -1,57584 -1,38869 -1,27148 -1,07678 -1,35219 -0,59693 -1,13568 -0,28626 -0,33743 -0,29954 0,041738 0,294868 0,737635 0,861347 0,052897 0,192746 NCI_PDGF_receptor_signaling_network_Pathway_ -0,06439 -0,13261 -0,06189 -1,28497 -1,57584 -1,38869 -1,27148 -1,07678 -1,35219 -0,59693 -1,13568 -0,28626 -0,33743 -0,29954 0,041738 0,294868 0,737635 0,861347 0,052897 0,192746 p38_Signaling_Pathway_Gene_Expression_Cell_M -0,2162 -0,48566 -0,57057 -0,98793 -0,2678 -0,07955 -2,49204 -2,18138 -2,91527 -1,25358 0,634833 -0,63174 1,083894 0,762056 1,401154 -1,12158 -1,42445 -0,75297 0,052885 0,192746 reactome_ADP_signalling_through_P2Y_purinoce 0,010601 -0,18541 -0,35131 2,681912 2,271829 1,430076 0,017036 -0,21932 -0,11865 -1,52808 1,479409 1,156664 -0,38168 -0,57824 -0,35809 -3,83726 -4,24567 -2,29261 0,052822 0,192746 reactome_Phenylalanine_and_tyrosine_catabolism -0,1457 0,17285 -0,05627 -1,7946 -1,79395 -2,34205 -0,75373 -0,69122 -0,61157 0,962635 -0,31279 -0,19218 -0,69579 0,07778 -0,59338 -0,67332 -0,6775 -1,06175 0,052905 0,192746 biocarta_prion_Main_Pathway -0,1064 -0,22437 0,056222 -0,58581 -0,02534 0,535128 -3,3784 -3,45757 -3,54035 1,624862 1,287043 0,998297 -0,12264 -0,43765 -0,16741 0,393378 -0,02786 0,082914 0,053135 0,193359 NCI_C_MYC_Main_Pathway 0,225649 -0,20824 -0,25563 -0,1561 -0,08614 -0,27387 -0,1205 0,233905 -0,94794 -2,18221 0,300631 -0,07317 -0,02706 0,109343 0,001451 -5,38562 -4,85146 -4,8705 0,053401 0,1941 ATM_Pathway_Checkpoint_Activation 0,032085 -0,00474 -0,05062 0,121962 0,338306 0,092602 -0,10225 0,006427 -0,2322 0,032121 -0,00106 0,084555 0,080394 -0,01004 -0,09356 -0,6476 -0,38474 -0,18285 0,054059 0,194417 biocarta_sodd_tnfr1_signaling_Main_Pathway 0,087194 -0,1064 0,081384 -0,7196 -0,354 -1,4953 -1,16193 -1,30099 -1,05524 0,152388 0,063058 1,099683 -0,4473 0,243267 -0,32709 -0,21233 -0,01337 -0,32878 0,053608 0,194417 Caspase_Cascade_Pathway 3,280789 2,477885 2,141268 3,758587 1,912174 6,65211 15,74759 16,30248 15,77365 5,015348 6,655193 4,469758 -4,49275 -3,41959 -6,61475 8,363146 9,15555 3,472678 0,054226 0,194417 Growth_Hormone_Signaling_Pathway_Cell_Surviv -0,32317 -0,42654 -0,34271 0,708567 0,830722 0,848353 0,546766 1,165046 -0,05108 2,113818 -0,49936 1,867472 0,573669 1,128685 1,225325 -2,53226 -1,70961 -0,27251 0,053962 0,194417 Growth_Hormone_Signaling_Pathway_Glucose_U -0,49226 -0,47555 -0,24677 -0,02742 -0,23253 0,529099 1,320242 1,827232 0,922149 0,95749 -0,37749 1,255241 0,219135 0,920538 1,304912 -2,53094 -1,87075 -1,11196 0,054174 0,194417 KEGG_Malaria_Main_Pathway -0,06241 -0,02218 0,092339 -0,56064 0,183114 -0,51059 -1,41526 -1,55671 -1,3611 1,162764 0,972841 0,851022 -0,29587 -0,67801 -0,52877 -0,10147 -1,03606 -0,31523 0,054237 0,194417 malate-aspartate_shuttle -0,05733 0,023398 -0,01842 -0,06795 -0,56765 -0,31564 -0,05958 -0,01322 -0,17978 -0,71657 -0,28882 -0,1646 0,274614 0,21263 0,294448 -0,91095 -1,08258 -1,15228 0,054208 0,194417 NCI_ATM_Pathway_(apoptosis) 0,072899 0,018742 -0,02978 0,286508 0,353468 0,651282 0,147041 0,141075 -0,08983 -0,30914 0,205494 0,278005 0,026144 -0,03493 -0,12504 -0,80081 -0,37322 -0,62063 0,054176 0,194417 NCI_Canonical_NF_kappaB_Main_Pathway 0,264556 -0,5053 -0,16968 -0,65609 -0,30481 -0,80374 -2,16357 -1,54419 -2,67873 -0,27159 -1,30617 -1,1193 -0,08136 -0,13266 0,701815 -4,70446 -3,64917 -2,3489 0,054164 0,194417 reactome_Activation_of_NF_kappaB_in_B_cells_M1,906999 0,608919 0,565419 0,144433 0,2808 -1,97286 0,343482 0,987814 -2,26486 -3,83602 -0,43694 -1,4598 1,469534 1,487903 2,05791 -21,1593 -17,1242 -14,4951 0,053816 0,194417 reactome_HuR_stabilizes_mRNA_Main_Pathway -0,02567 -0,20941 -0,13806 -0,38652 -0,44671 -0,54264 -0,98217 -0,78421 -1,16331 -1,25291 -0,34075 -0,47193 0,219846 0,260701 0,260773 -1,93557 -1,11171 -0,50966 0,054154 0,194417 reactome_Unwinding_of_DNA_Main_Pathway 0,444186 0,280814 0,221851 1,06419 0,950988 1,03887 3,727469 4,024205 3,018052 -0,98363 -0,64777 -0,79692 -0,55774 -0,77813 -0,43478 -3,44668 -1,90862 -1,87697 0,05415 0,194417 reactome_Formation_of_tubulin_folding_interme 0,187032 -0,35117 0,064293 0,143804 -0,66459 -0,97791 -1,53765 -1,39717 -1,73892 -2,11378 -1,58119 -0,91077 -0,26644 -0,58967 -0,23704 -7,09876 -5,43006 -4,70574 0,054486 0,194785 reactome_JNK_c_Jun_kinases_phosphorylation_a 0,132735 0,187801 0,069541 -0,28688 -0,12301 0,198385 0,194167 0,362447 -0,15485 -1,00899 0,157474 -0,15117 0,552425 0,378384 0,574297 -0,73368 -0,68148 -0,04231 0,054527 0,194785 reactome_Purine_ribonucleoside_monophosphat 0,186922 0,07855 0,027472 -0,5395 0,123213 -0,12859 -0,22698 0,011915 -0,64305 -0,22091 -0,36551 -1,03132 -0,07985 0,053386 0,331776 -2,91744 -2,36867 -1,67927 0,054498 0,194785 BRCA1_Pathway_Growth_Promoting_Genes_hTe 0,060939 -0,01354 -0,06223 0,548078 0,739161 0,154625 0,247518 0,527654 -0,13229 0,500146 0,11908 0,011833 -0,05245 0,050078 0,013126 -1,4546 -0,69733 -1,06115 0,05476 0,194946 NCI_VEGF_and_VEGFR_signaling_network_Main_ -0,10015 -0,02816 -0,05211 -0,5512 0,14072 -0,05347 -2,36148 -2,55627 -2,2511 0,357872 -1,58557 -0,78666 0,555705 0,522741 0,138797 -0,50567 -0,36723 -0,56854 0,054718 0,194946 reactome_Signaling_by_ERBB4_Main_Pathway -0,03073 -0,00881 0,463769 -1,22585 -1,26726 -2,021 -0,85345 -0,72287 -0,51367 0,741781 0,420989 -0,39239 -0,08265 0,100383 -0,07902 0,253275 -0,3153 -0,06347 0,054729 0,194946 biocarta_rb_tumor_suppressor_checkpoint_signa 0,22795 -0,06159 -0,00379 1,147786 0,575863 0,660238 1,278616 1,399848 1,032368 -0,03484 -0,03018 -0,41643 -0,10838 -0,27062 -0,05783 -0,95313 -0,6136 -0,40794 0,05517 0,196021 PAK_Pathway_Actin_Organization -6,07835 -1,57477 -0,44427 -10,8094 -3,37466 -10,2683 -7,52142 -11,69 0,0509 7,937854 -7,92645 -2,26322 -0,49337 -0,56851 0,723669 21,66689 15,85709 14,09732 0,055251 0,196021 PAK_Pathway_Cell_Survival -6,07835 -1,57477 -0,44427 -10,8094 -3,37466 -10,2683 -7,52142 -11,69 0,0509 7,937854 -7,92645 -2,26322 -0,49337 -0,56851 0,723669 21,66689 15,85709 14,09732 0,055251 0,196021 NCI_PDGFR_alpha_signaling_Pathway_(positive_r -0,09039 -0,17898 -0,1199 -1,9739 -2,2246 -1,53881 -3,38559 -3,28705 -3,63102 0,208856 -0,39032 0,149531 -0,18469 -0,12781 -0,41573 -0,66379 -0,34301 0,351751 0,05549 0,1962 NCI_PDGFR_alpha_signaling_Pathway_(Ras_prote -0,09039 -0,17898 -0,1199 -1,9739 -2,2246 -1,53881 -3,38559 -3,28705 -3,63102 0,208856 -0,39032 0,149531 -0,18469 -0,12781 -0,41573 -0,66379 -0,34301 0,351751 0,05549 0,1962 reactome_Activation_of_ATR_in_response_to_re 1,240083 0,09202 0,474231 3,366832 2,463728 1,283359 6,563608 8,117043 4,413987 -0,2199 -1,12418 -1,27128 -1,39485 -0,77546 -0,60746 -13,3404 -8,97841 -6,52365 0,055405 0,1962 adenine_and_adenosine_salvage_III -0,08544 -0,11765 -0,02288 -0,21692 -0,2268 0,049327 0,835816 0,892037 0,823728 -0,47499 0,088985 -0,54732 0,132485 0,233508 0,093682 -0,32196 -0,28474 -0,14056 0,055582 0,1963 reactome_Fatty_Acyl_CoA_Biosynthesis_Main_Pa 0,012127 -0,04741 -0,00024 -0,1182 -0,05871 0,144447 0,23402 0,189041 0,063071 -0,20268 0,35706 -0,58111 0,148941 -0,10102 0,0866 -1,00661 -0,78105 -0,77555 0,055807 0,196874 4-hydroxy-2-nonenal_detoxification -0,10445 0,000717 -0,02233 -1,72552 -1,09734 -1,27173 0,227374 0,2256 0,14316 0,548294 0,440475 0,489634 -0,25183 -0,13964 -0,26614 -0,24164 -0,85742 -0,97682 0,056006 0,197353 NCI_Regulation_of_RhoA_activity_Main_Pathway -0,40959 -0,40366 -0,35474 -1,17382 -0,24619 -0,07886 -0,13748 -0,72057 -0,40816 -5,36896 -0,53125 -1,21824 1,632196 0,821411 1,158561 -0,10257 -1,09622 -0,39951 0,056218 0,197876 reactome_DAP12_interactions_Main_Pathway -0,47491 0,597115 0,51402 0,601417 0,963828 0,745812 0,032451 -0,65681 0,948348 1,851036 1,438435 0,937915 -0,91172 -0,66588 -1,3095 1,196475 0,752268 1,511951 0,056358 0,198142 NCI_N_cadherin_signaling_events_Main_Pathway 0,001298 -0,30148 -0,25256 0,284488 0,355419 -0,97994 -1,89514 -1,69302 -2,62854 -0,22759 2,148383 -1,0081 0,981274 0,779407 1,449908 -6,96182 -5,08728 -4,40864 0,056508 0,198448 reactome_Recruitment_of_NuMA_to_mitotic_cen 0,265726 0,106971 -0,08341 -0,2956 0,069662 0,623186 0,986636 1,308905 0,267647 -0,18269 -0,74373 0,197986 -0,13479 0,034713 0,410095 -2,97605 -2,45675 -1,33524 0,056578 0,19847 reactome_SHC_mediated_signalling_Main_Pathw -0,09155 -0,18802 -0,20877 -0,78936 -0,49548 -0,68426 -0,99 -1,0206 -1,18436 -1,14095 -0,1511 -0,8803 0,447379 0,22681 0,384518 -2,39386 -1,75934 -1,2861 0,056728 0,19877 JNK_Pathway -3,6082 -2,12946 -1,08726 -8,33034 -0,45001 -9,2171 -16,6522 -19,6459 -11,1399 4,046286 0,333153 2,232949 1,850391 0,79858 1,87132 13,29095 10,36902 16,68205 0,056868 0,199001 NCI_Fanconi_anemia_Main_Pathway 1,052801 -0,03427 -0,14218 3,551318 4,489723 2,983087 5,423072 7,074588 2,868044 -1,09143 1,830296 0,08753 -1,43243 -0,97732 -0,60203 -13,7361 -9,19783 -6,49434 0,057113 0,199001 NCI_Retinoic_acid_receptors_mediated_signaling_ 0,109247 -0,21667 -0,64458 -1,08552 -0,47715 -0,86878 -1,31907 -0,62481 -2,40604 -1,78758 -0,44003 -1,74257 -0,3963 -0,0547 0,292856 -6,82207 -3,84363 -4,27801 0,056957 0,199001 reactome_APC_C_Cdh1_mediated_degradation_o 2,405971 0,754787 0,615376 -0,445 -0,9025 -3,71332 2,459821 3,215457 -1,50293 -9,00763 -2,35936 -1,87907 0,571597 1,36037 1,961534 -29,2586 -24,6815 -20,8731 0,057103 0,199001 reactome_CDT1_association_with_the_CDC6_ORC 2,355588 0,880501 0,651836 1,453911 1,190041 -1,54211 1,795403 2,6119 -1,66888 -4,81 1,062108 -1,0179 1,119674 1,814551 1,742981 -25,2368 -20,0479 -16,1461 0,057015 0,199001 NCI_HIV_1_Nef_Negative_effector_of_Fas_and_T 0,01944 -0,17415 -0,02507 0,095651 -0,31136 -1,09041 -1,75936 -1,78273 -1,71311 0,883782 0,16785 1,57001 -0,29855 0,055206 -0,43053 -0,39195 0,31262 -0,24029 0,057804 0,199313 reactome_Asymmetric_localization_of_PCP_prote -0,24267 -0,47784 -0,24406 -0,80987 0,075756 -1,35617 0,558722 0,634573 0,56032 -2,99283 -0,72249 -0,6274 0,28966 0,860351 0,207435 -2,25546 -1,29019 -0,88402 0,057802 0,199313 reactome_HIV_Transcription_Initiation_Main_Pat 0,87022 -0,27695 -0,19789 1,98279 0,774052 -0,57882 -0,74578 0,501956 -2,85716 -2,48982 -0,40108 1,194933 -0,18917 -0,1787 0,717003 -15,504 -12,3249 -10,075 0,057842 0,199313 reactome_RNA_Polymerase_II_HIV_Promoter_Es 0,87022 -0,27695 -0,19789 1,98279 0,774052 -0,57882 -0,74578 0,501956 -2,85716 -2,48982 -0,40108 1,194933 -0,18917 -0,1787 0,717003 -15,504 -12,3249 -10,075 0,057842 0,199313 reactome_RNA_Polymerase_II_Promoter_Escape_ 0,87022 -0,27695 -0,19789 1,98279 0,774052 -0,57882 -0,74578 0,501956 -2,85716 -2,48982 -0,40108 1,194933 -0,18917 -0,1787 0,717003 -15,504 -12,3249 -10,075 0,057842 0,199313 reactome_RNA_Polymerase_II_Transcription_Init 0,87022 -0,27695 -0,19789 1,98279 0,774052 -0,57882 -0,74578 0,501956 -2,85716 -2,48982 -0,40108 1,194933 -0,18917 -0,1787 0,717003 -15,504 -12,3249 -10,075 0,057842 0,199313 reactome_RNA_Polymerase_II_Transcription_Init 0,87022 -0,27695 -0,19789 1,98279 0,774052 -0,57882 -0,74578 0,501956 -2,85716 -2,48982 -0,40108 1,194933 -0,18917 -0,1787 0,717003 -15,504 -12,3249 -10,075 0,057842 0,199313 reactome_RNA_Polymerase_II_Transcription_Pre 0,87022 -0,27695 -0,19789 1,98279 0,774052 -0,57882 -0,74578 0,501956 -2,85716 -2,48982 -0,40108 1,194933 -0,18917 -0,1787 0,717003 -15,504 -12,3249 -10,075 0,057842 0,199313 reactome_SUMO_is_conjugated_to_E1_UBA2_SA 0,267992 0,13045 0,07724 0,263707 0,267056 0,10062 0,302089 0,420046 0,19468 -0,33611 -0,021 0,001122 -0,04199 0,150074 0,122334 -2,23069 -1,67595 -0,875 0,057294 0,199313 reactome_Transcription_of_the_HIV_genome_Ma 0,87022 -0,27695 -0,19789 1,98279 0,774052 -0,57882 -0,74578 0,501956 -2,85716 -2,48982 -0,40108 1,194933 -0,18917 -0,1787 0,717003 -15,504 -12,3249 -10,075 0,057842 0,199313 KEGG_p53_signaling_Main_Pathway 0,223202 0,052597 0,022036 1,032201 1,354099 0,962458 0,095142 0,467506 -0,5846 1,005626 0,128935 0,019311 -0,19453 -0,03504 0,126225 -2,0439 -0,88994 -1,25982 0,058078 0,199903 Base_Excision_Repair_Pathway 0,435849 0,099325 0,082888 -1,74703 -0,85077 0,451106 0,119293 0,779629 -0,45223 -2,78047 0,572306 -0,67295 0,627644 1,209835 1,417713 -4,82073 -4,21846 -3,57267 0,058338 0,199914 biocarta_transcription_regulation_by_methyltran -0,11786 -0,16665 -0,2846 -0,42718 -0,07292 0,382027 -1,20038 -1,04961 -1,41156 -0,48609 -0,07135 -0,17388 0,237758 0,135894 0,41456 -0,84564 -0,13449 0,179773 0,058333 0,199914 biocarta_transcription_regulation_by_methyltran -0,11786 -0,16665 -0,2846 -0,42718 -0,07292 0,382027 -1,20038 -1,04961 -1,41156 -0,48609 -0,07135 -0,17388 0,237758 0,135894 0,41456 -0,84564 -0,13449 0,179773 0,058333 0,199914 reactome_Synthesis_of_UDP_N_acetyl_glucosam 0,196013 0,030854 0,040002 0,36085 0,021387 0,377803 -0,76572 -0,59456 -1,01214 0,23709 -0,36212 0,32665 -0,02078 0,430718 -0,06821 -2,25118 -1,7301 -1,54159 0,058247 0,199914 reactome_STING_mediated_induction_of_host_im -0,05894 0,069173 0,037137 0,24271 0,109597 -0,25514 -0,309 -0,24327 -0,48302 0,789281 0,728051 0,46576 -0,08811 -0,22501 -0,25997 -0,10469 -0,09149 0,164865 0,058531 0,200355 NCI_Calcineurin_regulated_NFAT_dependent_tra -0,8115 -0,73595 -0,73113 -0,46731 -0,35399 -0,67725 -0,97888 -1,42212 -0,9007 1,806267 1,541078 0,943929 -0,8113 -0,0533 0,234639 0,342579 0,812461 0,573129 0,05866 0,200576 NCI_Regulation_of_nuclear_beta_catenin_signalin -0,29448 -0,71712 -0,67192 -0,6238 -1,66595 -2,14121 -1,06913 -0,74288 -1,61318 -0,54419 -1,81359 -1,7021 0,751669 0,424645 2,182353 -6,30536 -4,76696 -2,75497 0,058748 0,200656 biocarta_akap95_role_in_mitosis_and_chromosom -0,10214 -0,32888 -0,29247 -1,18874 -0,06344 -0,99663 0,384279 0,431154 -0,40966 -1,7649 -1,72811 -0,90242 -0,86088 -0,40394 -0,11936 -6,17229 -4,82003 -4,74901 0,059364 0,202097 biocarta_akap95_role_in_mitosis_and_chromosom -0,10214 -0,32888 -0,29247 -1,18874 -0,06344 -0,99663 0,384279 0,431154 -0,40966 -1,7649 -1,72811 -0,90242 -0,86088 -0,40394 -0,11936 -6,17229 -4,82003 -4,74901 0,059364 0,202097 biocarta_akap95_role_in_mitosis_and_chromosom -0,10214 -0,32888 -0,29247 -1,18874 -0,06344 -0,99663 0,384279 0,431154 -0,40966 -1,7649 -1,72811 -0,90242 -0,86088 -0,40394 -0,11936 -6,17229 -4,82003 -4,74901 0,059364 0,202097 NCI_BARD1_signaling_events_Main_Pathway 0,683326 0,270689 0,139361 0,942241 1,396527 1,020392 1,135758 1,629662 -0,13776 -0,75818 -0,26757 -1,1988 -0,56691 -0,5579 -0,46216 -3,78499 -2,21437 -1,32173 0,059618 0,20274 p38_Signaling_Pathway -8,42645 -2,92108 -2,295 -15,3597 -5,93265 -17,6572 -26,6932 -32,7037 -14,2863 17,40455 -7,15985 -4,42269 3,395538 1,437381 3,217676 34,42606 30,79891 30,3324 0,059818 0,203198 KEGG_Type_I_diabetes_mellitus_Main_Pathway -0,03177 1,095744 0,346206 -1,96643 -0,36065 1,295544 -0,26392 -1,10363 1,988795 2,207332 -1,10377 2,151641 0,55828 1,19678 0,301099 3,275232 3,923309 5,144905 0,059989 0,203553 NCI_p53_Main_Pathway 0,623416 -0,15815 -0,24671 1,077851 1,427934 0,475879 -0,82952 0,026406 -2,45168 -0,77071 0,801914 -0,38108 -0,63829 -0,11934 -0,01189 -10,3232 -6,99617 -6,89349 0,060053 0,203553 KEGG_Rheumatoid_arthritis_Main_Pathway -0,16381 -0,01543 -0,03785 -0,73525 -0,37464 0,205384 0,334104 0,311909 0,500731 1,623422 -1,03053 -0,12818 -0,52249 -0,05903 -0,34921 1,003966 1,168027 0,597435 0,060409 0,204536 reactome_Synthesis_of_IP3_and_IP4_in_the_cyto -0,01022 -0,11309 0,097576 -0,2108 -0,9374 0,057068 -0,05546 -0,39921 -0,5155 0,016024 0,474008 0,098155 -0,15522 0,17402 0,085666 0,378899 0,569122 0,792572 0,060535 0,204739 NCI_Signaling_events_regulated_by_Ret_tyrosine -0,01757 0,113825 0,065089 -0,41519 -0,18208 0,067482 -2,16129 -2,2742 -2,02698 0,372716 -0,35977 0,949496 -0,00295 -0,1921 -0,18773 0,104638 -0,24685 0,386181 0,060635 0,204858 reactome_Telomere_Extension_By_Telomerase_M -0,20303 -0,31576 -0,31917 -0,20939 -0,04307 0,001343 0,148237 0,291208 -0,12019 -0,3271 0,627717 -0,3475 -0,17638 0,166824 0,026607 -1,31042 -1,15232 -0,85319 0,061116 0,206257 biocarta_pelp1_modulation_of_estrogen_recepto -0,04853 -0,10033 -0,07917 0,134012 0,465835 0,430286 -0,47655 -0,49347 -0,52507 -0,01233 -0,38813 0,02097 0,052752 0,174501 0,093475 0,105097 -0,02454 0,542604 0,061398 0,206508 HIF1Alpha_Pathway_Gene_Expression_via_JUN_C -0,126 -0,44885 -0,30843 0,305781 1,374061 -0,28615 -1,65692 -1,3574 -1,82597 -0,14232 0,017419 1,379694 0,676801 -0,00742 0,281634 -2,8401 -2,209 -0,69388 0,061424 0,206508 KEGG_Glycosaminoglycan_biosynthesis_heparan_ -0,72832 -0,38879 -0,91086 0,337878 -1,23843 -0,71371 -0,22329 -0,09979 -0,19246 -2,03928 -0,9212 0,670949 1,339781 -0,31167 0,395242 -1,33486 -1,77677 -1,66453 0,06144 0,206508 reactome_Transcription_coupled_NER_TC_NER__ 0,045929 -0,1528 -0,19551 0,317261 -0,69533 -0,42363 -0,15698 0,227206 -0,50236 -1,60857 -1,05964 0,19338 -0,38672 -0,23051 -0,14238 -3,97554 -3,01083 -2,73586 0,061455 0,206508 biocarta_nfkb_activation_by_nontypeable_hemop 0,182521 -0,35788 -0,18085 0,543997 0,886284 0,642198 -1,20541 -0,85465 -1,4333 1,425175 0,652558 -0,06722 0,382711 0,010931 0,673848 -0,37469 -0,76023 -0,63581 0,061897 0,207769 L-carnitine_biosynthesis 0,046739 -0,10469 -0,16363 0,13154 -0,53789 -0,16005 1,112482 1,244622 0,79516 -0,1076 0,097492 -0,32069 0,28098 0,233789 0,463482 -1,80918 -0,81962 -0,83968 0,062059 0,207968 reactome_O_glycosylation_of_TSR_domain_conta -0,92872 -0,421 0,131881 -2,38441 -1,05186 -1,81428 -3,22503 -3,3495 -0,79466 1,160697 1,232556 -0,08674 0,801912 0,555305 1,350278 6,165091 5,254711 3,08858 0,06209 0,207968 biocarta_fc_epsilon_receptor_i_signaling_in_mast -0,05042 -0,25519 -0,12912 -0,27351 -0,54537 -0,77939 -0,48815 -0,39573 -0,43421 -0,13234 0,254666 0,537519 0,114656 -0,14655 0,006843 -0,04937 0,135588 0,407951 0,062547 0,208601 NCI_Validated_transcriptional_targets_of_TAp63_ 0,200149 0,088743 0,291474 -0,44851 -0,62642 -0,39308 -1,63415 -1,50228 -1,60489 0,892152 0,626856 -0,09247 0,18603 0,513488 0,564641 0,75353 0,911497 0,794223 0,062491 0,208601 NCI_Validated_transcriptional_targets_of_TAp63_ 0,200149 0,088743 0,291474 -0,44851 -0,62642 -0,39308 -1,63415 -1,50228 -1,60489 0,892152 0,626856 -0,09247 0,18603 0,513488 0,564641 0,75353 0,911497 0,794223 0,062491 0,208601 reactome_APC_C_Cdc20_mediated_degradation_ 0,681226 -0,01923 0,021608 -0,86466 -1,15237 -2,22948 1,371633 1,913446 -0,06283 -4,95189 -2,06579 -1,8958 -0,62076 -0,12759 -0,03283 -9,73117 -8,44034 -7,06358 0,062384 0,208601 reactome_Antigen_activates_B_Cell_Receptor_BC -0,00321 -0,19294 0,07708 0,906602 1,395185 -0,08302 0,418016 -0,1866 0,658152 -0,48384 0,161884 0,688301 0,253027 -0,57765 0,07275 -2,13011 -1,33586 -1,83636 0,062722 0,208962 NCI_p75_NTR_mediated_signaling_Pathway_(acti -0,03409 0,096822 0,065579 0,504357 0,547527 0,691753 -0,56754 -0,58134 -0,63079 -0,30777 0,633578 0,19864 0,149383 -0,071 -0,05775 -0,70268 -0,30817 -0,50637 0,062814 0,209043 biocarta_atm_signaling_Main_Pathway -0,00254 -0,11244 -0,25558 2,078005 1,629631 1,387654 0,725681 1,383184 0,125382 -0,20613 0,725178 0,061228 -0,30092 -0,49703 -0,44546 -3,02962 -1,43019 -1,40425 0,063383 0,209594 biocarta_induction_of_apoptosis_through_dr3_an -0,00164 -0,13568 -0,07256 -0,87791 -1,06305 -1,83957 -1,84177 -1,67317 -1,58831 0,03159 -0,19657 1,351515 0,082067 -0,05772 -0,38587 -0,05945 -0,1484 -0,43655 0,063107 0,209594 isoleucine_degradation 0,203953 0,08497 0,131978 -0,49664 0,844384 0,524457 0,823011 1,05954 0,476942 0,160184 -0,08282 -0,2118 -0,17133 0,289337 0,237966 -4,31752 -3,30747 -2,75257 0,063348 0,209594 KEGG_Carbohydrate_digestion_and_absorption_M -0,09827 -0,02245 0,027533 -0,71492 0,250572 -0,82404 0,131842 0,158115 0,674349 -0,49544 0,247829 0,048 -0,02709 -0,13931 0,292392 1,863585 1,751055 1,517117 0,063264 0,209594 reactome_Cyclin_B2_mediated_events_Main_Pat 0,214585 0,125996 0,1196 0,062339 -0,2643 -0,50437 0,836191 1,064885 0,609901 -0,36305 -1,79408 -1,07688 -0,05095 -0,17191 0,050906 -1,91981 -1,02142 -0,99262 0,063315 0,209594 reactome_Transport_of_nucleosides_and_free_p -0,32029 0,06725 -0,10092 0,315387 -0,96357 -0,16291 0,409953 0,247994 0,929661 0,231607 0,558019 0,515873 0,143968 0,322507 0,182239 2,360804 1,573687 1,483408 0,063335 0,209594 KEGG_Cholinergic_synapse_Main_Pathway -0,2968 -0,72759 -0,83281 3,093657 3,204382 1,371454 1,521131 1,590951 0,450293 -0,26907 2,085231 1,425413 -1,23331 -0,33978 0,156031 -7,5913 -5,70611 -2,45647 0,063452 0,209601 biocarta_cxcr4_signaling_Main_Pathway -0,15601 -0,03214 -0,15908 0,6875 -0,2381 -0,30801 -0,62056 -0,41278 -0,70528 1,435044 -0,35096 -0,6764 0,095005 0,290534 0,741343 -4,23134 -4,27702 -3,05947 0,063794 0,210507 KEGG_Cysteine_and_methionine_metabolism_Ma 0,114011 -0,06486 -0,17815 -0,01757 -1,44688 -0,37385 0,332414 0,854007 0,112053 -0,65115 -0,42422 -0,17788 0,758535 0,54477 0,561249 -4,14974 -3,58893 -3,0104 0,063877 0,210557 Akt_Pathway_Regulation_by_GH -0,47618 -0,90417 -0,86136 -0,21703 0,253018 -1,99535 -2,60222 -2,31877 -4,06182 -1,3412 1,007199 0,460563 0,457861 1,011197 1,635643 -7,58086 -4,35719 -3,23674 0,064095 0,210829 reactome_Negative_regulation_of_the_PI3K_AKT 0,024036 -0,03634 -0,16464 1,09177 1,434595 0,320719 -1,52513 -1,52283 -1,99845 0,298444 0,508725 -0,23331 0,342355 0,001382 0,274888 -0,08811 -0,54921 0,478443 0,06404 0,210829 NCI_LKB1_signaling_events_Main_Pathway -0,00856 -0,29772 -0,32859 -0,0786 0,230726 -1,94629 -0,95072 -0,60286 -1,03333 -2,55298 0,702289 -0,44695 0,679951 0,823207 0,407361 -3,25696 -3,32727 -2,29658 0,064165 0,210837 NCI_IL8_and_CXCR1_mediated_signaling_events_ -0,08674 -0,19752 0,128439 -0,30894 0,053143 -1,23793 -0,2129 -0,1573 -0,03748 1,416681 -0,10592 0,353673 -0,06463 0,198227 0,442608 0,879197 0,834981 1,204852 0,064323 0,211134 biocarta_sprouty_regulation_of_tyrosine_kinase_ 0,039008 0,108183 0,00149 0,207674 0,344658 0,017658 0,618155 0,697972 0,746449 -0,12855 0,073621 0,196377 -0,38796 -0,33218 -0,51098 0,779132 0,962773 0,473373 0,064648 0,211318 EGF_Pathway_EGFR_Endocytosis -0,02604 -0,06643 -0,11898 -0,04667 0,111245 -0,37447 0,7073 0,832661 0,43897 -1,12635 -0,31777 -0,40029 -0,19259 -0,26738 -0,08914 -0,73618 -0,57206 -0,43287 0,064922 0,211318 NCI_Endogenous_TLR_signaling_Pathway_(regula 0,051097 0,10742 -0,00329 -0,01732 0,041911 -0,51113 -1,26509 -1,06988 -0,84825 0,967153 1,099421 0,135295 -0,27681 -0,79845 -0,00907 0,118526 -0,50376 -0,28491 0,064721 0,211318 NCI_Endogenous_TLR_signaling_Pathway_(regula 0,051097 0,10742 -0,00329 -0,01732 0,041911 -0,51113 -1,26509 -1,06988 -0,84825 0,967153 1,099421 0,135295 -0,27681 -0,79845 -0,00907 0,118526 -0,50376 -0,28491 0,064721 0,211318 NCI_Notch_signaling_Main_Pathway -0,06372 0,061452 -0,2903 -1,19687 1,093209 0,733191 -0,5269 0,038211 -1,60615 -0,65785 -0,09501 -0,8655 -0,17636 0,101511 -0,03199 -6,23335 -2,87967 -2,20102 0,064533 0,211318 NCI_PDGFR_beta_signaling_Pathway_(ruffle_orga -0,18735 -0,32044 -0,50864 0,461905 -0,9512 -0,69934 -1,1794 -1,19625 -1,84495 -1,22604 -0,26269 -0,38454 -0,35138 0,03775 0,926499 -7,94705 -4,81014 -3,03291 0,064912 0,211318 reactome_The_NLRP3_inflammasome_Main_Path 0,128001 0,068229 0,114187 -0,40039 0,104777 -0,99742 -0,15965 -0,28499 -0,3945 -1,08463 -0,58253 -1,57678 -0,12417 -0,37979 0,22641 -2,87184 -1,99474 -2,1476 0,064573 0,211318 VEGF_Pathway_Focal_Adhesion_Turnover 0,006604 0,000506 -0,08566 -0,9518 -0,25452 -0,43763 -0,80132 -0,79721 -0,80796 0,294548 0,456176 0,028402 0,25351 0,161917 0,099159 0,710757 0,758533 0,254914 0,064898 0,211318 adenosine_nucleotides_degradation -0,0234 0,037719 -0,07417 0,737858 0,103224 -0,5396 1,054295 1,110858 0,926491 -0,93038 -0,50858 -0,46333 0,268831 -0,09306 0,229286 -0,4423 -0,41264 0,016561 0,065305 0,212115 NCI_Fanconi_anemia_Pathway_(Sister_Chromatid 0,682763 -0,03141 -0,11221 1,766635 2,421504 0,92055 3,382572 4,492792 1,865857 -0,00636 0,686862 -0,11306 -0,60376 -0,6093 -0,2323 -9,19215 -6,40569 -4,5781 0,065306 0,212115 reactome_Cross_presentation_of_soluble_exogen 1,6159 0,97878 0,786763 -0,45418 0,241129 -1,63379 0,411122 0,628184 -1,88759 -1,69131 -1,0124 -0,28787 1,40486 2,064265 1,93001 -17,7568 -15,1256 -12,5959 0,065371 0,212115 KEGG_Retrograde_endocannabinoid_signaling_M 0,727065 -0,00692 0,074612 2,85372 2,210547 2,051358 2,070762 2,167626 1,422245 0,380055 2,887366 -0,03883 0,278834 -0,60898 -0,05701 -5,99232 -6,64199 -4,12579 0,065864 0,21305 reactome_Calmodulin_induced_events_Main_Pat 0,000123 -0,21533 -0,00985 -0,32837 -0,45095 -0,70203 -0,38688 -0,27899 -0,29826 -0,30035 -0,23586 -0,59102 -0,37682 -0,23679 0,027291 0,269441 0,194784 0,359894 0,06573 0,21305 reactome_Creatine_metabolism_Main_Pathway 0,031768 -0,10947 -0,04933 -0,00249 0,485788 0,62259 -0,84324 -0,76972 -0,55481 1,313853 0,453456 0,452856 -1,56912 -1,07644 -0,89363 0,709071 0,578384 0,830822 0,065834 0,21305 CXC_Chemokine_Receptor_Pathway -0,38844 -0,88405 -0,95747 1,558982 0,771686 -0,53976 -2,97371 -3,00305 -3,60361 -2,04071 0,262608 1,730995 -0,9667 -0,61979 0,244048 -6,98164 -5,99226 -3,21994 0,06609 0,213337 reactome_Synthesis_of_PIPs_at_the_ER_membra 0,05161 0,054825 -0,04948 0,131192 0,172425 0,252947 -0,7277 -0,61593 -0,94034 -0,15486 -0,2479 -0,06221 -0,25486 -0,13804 -0,17166 -1,28502 -1,06047 -0,73083 0,066022 0,213337 reactome_Synthesis_of_PIPs_at_the_early_endos 0,217438 -0,14291 -0,27543 -0,821 -1,17007 0,049118 -0,61206 -0,09274 -1,27558 -3,06329 -1,44412 -1,66661 -0,66581 -0,30528 -0,45956 -2,87514 -2,01039 -1,6268 0,066179 0,213402 NCI_IFN_gamma_Main_Pathway 0,322933 -0,18998 -0,41785 0,431562 0,250275 0,134149 -1,5953 -1,00031 -2,4664 -1,96981 0,82606 -0,62501 -0,2639 -0,17603 0,739348 -3,74179 -1,61173 -0,06575 0,066365 0,213782 NCI_S1P5_Main_Pathway 0,034551 -0,07978 -0,10855 0,70878 -0,00176 0,182091 -0,31761 -0,27942 -0,3018 -0,2068 0,562503 -0,29288 -0,04204 -0,34879 -0,00203 -2,01666 -2,32522 -1,83009 0,066678 0,214346 reactome_PI3K_events_in_ERBB2_signaling_Main -0,05955 -0,05612 -0,15368 -0,23868 -0,01561 0,232846 0,029581 0,063931 -0,09788 -0,14143 0,042228 0,244725 0,084129 0,108984 0,194216 -1,07709 -0,52887 -0,39653 0,066636 0,214346 citrulline-nitric_oxide_cycle -0,16151 -0,18874 -0,0133 -0,04983 -0,04315 -0,082 0,092833 -0,19395 0,179881 0,313329 -0,02688 -0,09878 -0,16286 -0,10133 -0,22785 1,033319 0,359586 1,396155 0,066836 0,214632 KEGG_Proteasome_Main_Pathway 1,77627 0,922599 0,658617 0,284535 0,317422 -1,43064 0,532361 0,753085 -1,73926 -3,13149 -0,12226 0,021837 0,882516 1,322374 1,903584 -19,1806 -15,4618 -13,211 0,067016 0,21487 reactome_Autodegradation_of_Cdh1_by_Cdh1_A 2,31402 0,817295 0,728042 -0,14654 -1,38967 -3,18341 0,210327 1,045725 -3,30972 -8,25168 -1,18961 -0,73043 0,631856 1,208523 2,021438 -27,1482 -22,7212 -18,7846 0,067108 0,21487 reactome_Ubiquitin_Mediated_Degradation_of_P 1,887268 0,77981 0,664337 0,486015 0,460324 -1,79377 0,826119 1,38112 -1,98912 -3,63638 -0,13494 -0,37011 0,894464 1,209453 1,606055 -22,9196 -18,4026 -15,3718 0,067186 0,21487 valine_degradation 0,257045 0,052825 0,113141 0,154985 0,723101 -0,03245 1,180032 1,584944 0,561322 0,283558 0,66937 -1,12039 -0,24431 0,118741 0,427724 -4,10403 -3,58939 -2,81677 0,067135 0,21487 KEGG_Vitamin_digestion_and_absorption_Main_ -0,31587 -0,37713 -0,06932 -0,75768 1,051608 0,129824 0,215967 -0,26228 0,762976 2,080326 0,933453 0,381207 -0,39188 0,41585 0,137352 3,067632 2,752488 1,63503 0,067485 0,215304 NCI_Trk_receptor_signaling_mediated_by_the_M 0,489026 -0,18542 -0,19561 -0,62805 0,113404 0,178312 -1,34364 -0,77123 -2,76619 -2,65649 0,962902 -2,01481 -1,06758 0,416039 -0,15422 -5,84231 -3,3649 -3,46286 0,067418 0,215304 reactome_p53_Dependent_G1_DNA_Damage_Re 0,25296 0,00605 0,00666 0,815478 1,401306 -0,30459 1,261426 1,325821 0,984402 0,140679 0,92485 0,135809 0,046771 0,298656 0,251165 -2,04422 -2,06848 -1,67691 0,067529 0,215304 D-imyoi-inositol-5-phosphate_metabolism -0,0305 -0,1876 -0,09496 0,265412 0,720205 -0,2366 -0,24531 0,093605 -0,65527 -2,44913 -0,2799 -0,69006 0,665809 0,190867 0,96753 0,241074 0,080594 0,887786 0,068256 0,215399 IL-2_Pathway_Apoptosis -0,01779 -0,04014 0,039423 0,114022 -0,2575 -0,35388 0,241156 0,066566 0,162079 0,314201 0,544888 0,086688 0,175726 -0,05255 0,108306 0,809531 0,448 -0,1141 0,06831 0,215399 KEGG_Apoptosis_Main_Pathway 0,067904 0,120341 0,101508 -0,95432 -0,55305 -1,9931 -5,13071 -4,94047 -4,72576 6,048309 2,230934 4,803765 1,293576 0,333489 -0,10385 -0,06886 0,818921 -0,57313 0,068183 0,215399 KEGG_Gastric_acid_secretion_Main_Pathway -0,57303 -0,08104 -0,16377 -2,85563 -2,31839 -2,64106 -0,67539 -0,41107 -0,07688 1,608992 -0,57499 -0,03789 0,317432 1,638675 0,945624 4,246517 4,270637 3,522834 0,06814 0,215399 KEGG_Nucleotide_excision_repair_Main_Pathway 1,11947 -0,24128 -0,34018 -0,4117 1,498933 1,978623 1,298116 3,202186 -0,93447 -0,80817 0,155262 1,74046 -0,43548 0,527165 0,78903 -16,9843 -15,8438 -12,5337 0,068241 0,215399 NCI_PDGFR_beta_signaling_Pathway_(focal_adhe 0,099922 0,029599 0,043592 0,037354 0,069746 -0,34046 -0,25629 -0,23107 -0,36699 -0,98141 -0,30992 0,234613 -0,0488 0,238847 -0,06316 -1,28381 -0,97247 -0,8132 0,068006 0,215399 reactome_Activation_of_G_protein_gated_Potass -0,20437 -0,26192 -0,37996 0,507273 0,656392 0,001307 -0,049 -0,21358 -0,13445 -1,31066 1,104416 0,66541 -0,12443 -0,14546 0,260389 -2,0758 -1,9248 -0,98977 0,068059 0,215399 reactome_degradation_of_DVL_Main_Pathway 1,663868 0,769387 0,669533 -0,6052 -0,09021 -2,864 0,154989 0,612364 -2,36527 -4,57359 -0,40897 -0,64837 1,401732 1,346834 2,158084 -22,7979 -18,1775 -15,5044 0,068319 0,215399 reactome_Inhibition_of_voltage_gated_Ca2_chan -0,20437 -0,26192 -0,37996 0,507273 0,656392 0,001307 -0,049 -0,21358 -0,13445 -1,31066 1,104416 0,66541 -0,12443 -0,14546 0,260389 -2,0758 -1,9248 -0,98977 0,068059 0,215399 reactome_Pregnenolone_biosynthesis_Main_Path 0,075191 -0,04654 0,029012 0,261382 -0,78048 0,968928 0,099478 0,542162 0,279215 0,679441 -0,28435 -0,5017 -0,08089 0,048628 0,506802 -2,17404 -2,52087 -2,70746 0,06775 0,215399 reactome_Transport_of_nucleotide_sugars_Main 0,272682 -0,10759 0,026106 -0,45172 -1,11543 -0,26949 -0,80748 -0,61014 -1,27655 -0,86596 -1,14328 -1,71502 0,136937 0,434839 -0,22087 -2,35821 -1,35444 -1,55483 0,067922 0,215399 biocarta_signaling_pathway_from_g_protein_fam 0,068988 -0,4664 -0,44633 0,910937 -0,44709 -0,51957 -1,43527 -0,99421 -1,86404 -2,12022 -0,92659 -1,83176 -1,65739 -1,501 -0,31888 -5,93006 -5,28633 -3,03378 0,068501 0,215754 KEGG_HTLV_I_infection_Main_Pathway 1,926471 0,995383 0,631473 2,143177 1,018538 3,174528 1,795536 2,909653 -1,37395 -1,33312 2,345403 -0,84102 -0,06395 -0,60851 0,556687 -8,86738 -7,06077 -6,17962 0,068906 0,216811 Chemokine_Pathway_Gene_Expression_and_Apo 0,154548 -0,16997 -0,09933 0,429731 -0,46226 -0,69384 -0,5413 -0,17396 -0,8105 -1,31457 0,524145 -0,60848 0,401281 0,167688 0,417334 -1,3786 -1,52953 -0,84289 0,069544 0,216846 glycine_betaine_degradation -0,15376 0,130128 -0,01944 -0,91954 -1,15455 -0,46339 -0,06407 -0,18509 0,088024 0,310137 0,035832 -0,01871 0,273418 0,165943 0,266659 1,430623 0,693026 0,553398 0,069196 0,216846 IGF1R_Signaling_Pathway_Cell_Survival -0,036 0,009311 -0,0941 0,341122 0,280609 -0,43897 -1,34251 -1,40115 -2,04691 -0,10421 0,40107 -0,246 0,226763 0,159378 0,236494 -3,01021 -1,92129 -0,97185 0,069534 0,216846 NCI_IL27_mediated_signaling_events_Main_Pathw0,006425 -0,32476 -0,01426 -0,93583 -0,43131 -1,27415 -0,58911 -0,53498 -0,68775 1,840059 1,130417 0,910197 -0,51649 -0,07275 0,192863 -0,76988 0,017483 -0,77181 0,069468 0,216846 PTEN_Pathway_Angiogenesis_and_Tumorigenesis -2,61834 -0,71965 -0,31397 -8,70053 -6,03993 -5,17202 -1,91174 -3,48844 2,693364 -0,24131 -5,79072 -3,09129 2,431619 -0,36826 -0,36009 28,91484 26,82718 23,19761 0,069256 0,216846 PTEN_Pathway_Ca2+_Signaling -2,61834 -0,71965 -0,31397 -8,70053 -6,03993 -5,17202 -1,91174 -3,48844 2,693364 -0,24131 -5,79072 -3,09129 2,431619 -0,36826 -0,36009 28,91484 26,82718 23,19761 0,069256 0,216846 reactome_G_protein_activation_Main_Pathway -0,10991 -0,15746 -0,41734 2,144294 2,076146 1,15748 -0,0669 -0,32314 0,220296 -1,47086 1,354031 0,652581 -0,20593 -0,3756 -0,47271 -1,94605 -3,4582 -0,41178 0,069416 0,216846 VEGF_Pathway_Actin_Reorganization -0,32453 -0,34327 -0,42787 0,259251 -0,48357 -0,0665 -1,36692 -1,29665 -1,25035 -0,95958 -0,27562 0,627215 0,632883 0,21509 0,805135 -0,2932 -0,12567 -0,1391 0,069366 0,216846 VEGF_Pathway_Cell_Migration -0,32453 -0,34327 -0,42787 0,259251 -0,48357 -0,0665 -1,36692 -1,29665 -1,25035 -0,95958 -0,27562 0,627215 0,632883 0,21509 0,805135 -0,2932 -0,12567 -0,1391 0,069366 0,216846 NCI_Proteoglycan_syndecan_mediated_signaling_ -0,08333 -0,20903 -0,16736 -0,18398 -0,2745 -0,25883 -0,05106 -0,04386 -0,16452 -0,50004 -0,43564 -0,2314 -0,1589 -0,03417 0,016441 -0,38708 -0,38635 -0,16107 0,069651 0,216963 histidine_degradation -0,01954 -0,09374 -0,01267 0,017268 0,248484 0,259027 -0,02822 -0,06733 0,197402 0,428685 0,411502 0,352656 0,003761 -0,15651 -0,15612 0,694461 0,646638 0,114981 0,06988 0,217331 reactome_APC_C_Cdc20_mediated_degradation_ 2,327659 0,779413 0,717772 -0,70514 -1,16208 -3,99087 1,048784 1,831857 -2,74004 -7,84716 -1,1493 -1,59376 0,607016 1,305473 1,917762 -28,5624 -24,1619 -20,5485 0,069978 0,217331 zymosterol_biosynthesis 0,188121 0,111334 -0,07583 1,154265 0,603864 1,231654 0,292412 0,4004 0,050955 0,617436 0,0492 1,302808 -0,19903 0,183267 0,204231 -2,67589 -2,43903 -1,77442 0,069957 0,217331 NCI_p53_Pathway_(proteasomal_ubiquitin_depen 0,003291 -0,10156 -0,10872 0,037352 0,43306 0,04052 -0,13416 -0,07064 -0,26402 0,320497 0,025203 -0,21924 -0,18194 -0,04508 -0,01274 -1,264 -1,00089 -0,86155 0,070084 0,217443 reactome_SCF_Skp2_mediated_degradation_of_p 2,237099 0,627308 0,700361 0,525919 0,935846 -2,77285 1,872491 2,620151 -1,00901 -5,33774 0,572209 -0,3605 0,724467 1,266536 1,596859 -25,6878 -21,4334 -17,0276 0,070583 0,218773 reactome_Signalling_to_RAS_Main_Pathway -0,13016 -0,24268 -0,20198 -0,98339 -0,42849 -0,41337 -0,88994 -1,08973 -0,92699 -1,12879 -0,29372 -0,34122 0,654101 0,291742 0,527813 -2,21125 -1,46705 -0,88965 0,070738 0,219036 biocarta_apoptotic_signaling_in_response_to_dna 0,186959 0,041244 -0,03625 0,119104 0,208901 0,533358 -0,71358 -0,45801 -0,9994 0,830232 -0,49278 -0,78176 0,108946 -0,05315 -0,35749 -2,29958 -1,66702 -1,44624 0,071182 0,219795 NCI_E_cadherin_signaling_in_the_nascent_adher 0,186697 -0,04572 0,03202 -0,03977 -0,37553 -0,27003 -0,17832 -0,02799 -0,43186 -1,07153 -0,5434 -0,06798 -0,17504 0,205886 -0,12935 -1,59522 -1,37345 -1,02219 0,071283 0,219795 NCI_Glucocorticoid_receptor_regulatory_network -0,04722 -0,29009 -0,25777 -0,73566 0,091537 -0,07935 -1,05927 -0,82274 -1,52461 -0,75574 -0,67716 0,492482 -0,73264 0,327491 0,674839 -5,34612 -4,52461 -2,87322 0,071093 0,219795 NCI_Role_of_Calcineurin_dependent_NFAT_signa -0,01372 -0,47546 -0,26213 -0,75529 -1,35993 -1,48695 -2,73989 -2,59885 -3,26606 -2,68828 -0,53206 -2,55117 0,765306 0,714719 1,589645 -3,77791 -2,19542 -0,66814 0,071276 0,219795 reactome_Retinoid_metabolism_and_transport_M -0,84474 -0,15676 0,305868 -1,15617 0,564727 -1,05455 -2,36332 -3,38995 -1,37821 0,095594 0,560498 -0,49994 0,313282 0,089359 -0,62923 5,770847 5,600671 3,009264 0,071336 0,219795 NCI_mTOR_signaling_Pathway_(Pathway_rRNA_t 0,182389 0,022472 -0,02022 0,623156 0,860208 -0,64821 -0,36285 -0,28933 -0,98636 0,969532 0,539576 -0,3958 0,367343 0,526354 0,636297 -1,94744 -1,96984 -1,13813 0,071912 0,221351 reactome_Astrocytic_Glutamate_Glutamine_Upta -0,07055 0,179871 0,025928 -0,52941 -0,25169 -0,3897 -1,25705 -1,21569 -1,60375 0,690068 0,628882 0,276449 -0,0731 0,016823 0,326073 -0,47094 0,032639 0,465091 0,072099 0,221707 superpathway_of_inositol_phosphate_compound -0,55422 -0,71219 -0,779 -1,22802 -1,15979 -0,2803 -0,45877 0,33656 -1,85889 0,199987 -1,47735 0,484458 -0,32452 0,667186 0,888125 -6,69355 -5,52517 -4,13745 0,072684 0,223286 reactome_GRB2_events_in_EGFR_signaling_Main 0,061213 -0,12489 -0,09101 -0,61156 -0,27751 -0,58518 0,506253 0,645646 0,242779 -1,38911 -0,15963 -0,91255 -0,17222 -0,05413 0,079091 -1,96924 -1,45208 -1,32531 0,072764 0,223309 NCI_IL5_mediated_signaling_events_Pathway_(pr -0,0563 -0,21668 -0,03447 0,083006 0,206554 -0,23411 0,136316 0,198653 0,21121 0,247587 0,379609 -0,23992 -0,59654 -0,29931 -0,24773 0,167235 0,622446 0,194159 0,072911 0,223542 GSK3_Signaling_Pathway_b-CTNN_Degradation 1,262924 0,66358 0,648814 1,197572 -0,04402 -0,57426 -0,43301 -0,16523 -2,1063 -3,08372 1,216508 0,354747 0,450047 0,803731 1,020258 -14,5023 -11,9736 -10,1166 0,073252 0,223926 JAK-STAT_Pathway_JAK_Degradation -1,26292 -0,66358 -0,64881 -1,19757 0,044024 0,574259 0,433011 0,165226 2,106302 3,083723 -1,21651 -0,35475 -0,45005 -0,80373 -1,02026 14,50233 11,97356 10,1166 0,073252 0,223926 reactome_RSK_activation_Main_Pathway 0,073044 0,042511 -0,09948 0,028082 -0,10115 -0,314 -1,196 -1,19484 -1,69286 -0,95526 0,681436 0,046008 0,228314 0,08706 0,417977 -2,30727 -2,14501 -1,92858 0,073176 0,223926 NCI_ALK1_signaling_events_Pathway_(endothelia -0,01979 0,076168 -0,00932 0,010232 -0,00208 -0,03462 -0,59454 -0,56887 -0,83324 -1,46106 -0,30422 -0,34727 0,106846 0,023065 0,197818 -0,84859 -0,24872 0,279745 0,073393 0,224136 histamine_degradation -0,012 -0,12271 0,021678 0,346269 0,020701 0,275136 -0,17499 -0,17588 -0,18676 0,097057 -0,46224 -0,11402 -0,02644 -0,20242 0,098791 -0,49026 -0,24176 0,123664 0,073957 0,225261 reactome_Autodegradation_of_the_E3_ubiquitin_ 1,828489 0,721673 0,610783 0,325523 0,331794 -1,88917 0,603417 1,10196 -2,12041 -3,4094 0,677478 0,302838 1,098065 1,395586 1,80175 -22,1374 -17,9903 -15,3144 0,07405 0,225261 reactome_Interconversion_of_polyamines_Main_ -0,00101 -0,08148 0,017604 -0,85121 -0,92247 -0,69002 -0,67793 -0,6502 -0,72317 -0,06908 0,233523 0,163133 0,128223 -0,08954 0,009974 -0,23806 -0,03172 0,290623 0,073962 0,225261 reactome_Pyrimidine_biosynthesis_Main_Pathwa 0,098477 0,041969 0,056947 0,232629 0,412977 0,178681 0,411525 0,485602 0,17778 -0,42795 0,53747 -0,05304 0,008133 -0,1585 0,096919 -1,66047 -0,85826 -0,8784 0,074002 0,225261 Estrogen_Pathway_Vasodilatation 0,090281 0,007924 0,015206 -0,35439 0,05132 0,242373 0,084225 -0,01032 0,083732 -0,18588 0,317239 0,109956 -0,03822 -0,01133 -0,13723 0,521848 0,4007 0,291144 0,074503 0,225976 KEGG_Morphine_addiction_Main_Pathway -0,6354 -0,13251 -0,12691 -2,65258 -2,52943 -2,68636 -1,68362 -1,29065 -1,0907 1,228606 -1,85492 0,191112 -0,09653 1,194654 1,439564 4,73489 5,001265 4,120235 0,074496 0,225976 Ras_Pathway -4,11879 -4,77347 -3,10831 -4,88884 -0,33346 -7,95321 -19,3715 -19,6999 -18,3648 -0,422 -5,48546 -7,87628 6,179047 6,131652 8,176454 -10,0838 -8,51264 -0,45549 0,074365 0,225976 NCI_Regulation_of_nuclear_SMAD2_3_signaling_ -0,2474 -0,16136 -0,47743 -0,77495 -0,74324 0,095398 -2,89816 -3,12424 -3,31608 -0,08129 -0,47982 -0,24895 -0,45313 -0,20851 -0,06737 2,489354 2,171623 1,3704 0,074746 0,226493 ErbB_Family_Pathway_Translation 0,033482 -0,05188 0,004434 0,080418 0,381772 -0,29725 0,099466 0,161997 -0,06601 0,127539 0,403956 -0,02032 0,2166 0,257591 0,404308 -0,90488 -0,44578 -0,54104 0,07532 0,227915 ERK_Signaling_Pathway -10,3004 -3,88195 -1,83813 -26,6048 -11,4392 -21,7881 -26,0252 -31,9828 -12,0155 9,17472 -6,67821 -7,91583 4,975392 3,836504 5,207329 42,6101 35,71193 36,10656 0,075362 0,227915 allopregnanolone_biosynthesis -0,01307 -0,10817 -0,03099 0,391989 0,297074 0,057789 0,0688 -0,00849 0,244664 0,203065 -0,22122 0,039617 0,183311 0,117624 0,314906 0,346632 0,316187 0,081912 0,075539 0,228023 NCI_Retinoic_acid_receptors_mediated_signaling_ 0,009276 -0,09158 -0,57254 -0,78037 0,194374 -0,54798 -2,03788 -1,38281 -2,66108 -1,29912 -0,31487 -0,10965 -0,61019 0,158424 0,167052 -4,26153 -2,27071 -2,61381 0,075544 0,228023 biocarta_double_stranded_rna_induced_gene_ex 0,146847 -0,02621 0,023614 0,06996 -0,24214 0,130087 -0,32321 -0,12537 -0,49194 -0,40853 -0,78054 -1,3553 -0,13782 -0,16378 0,014355 -0,3394 -0,55829 -0,17149 0,075821 0,228433 heme_biosynthesis_from_uroporphyrinogen-III_I 0,087043 -0,06176 0,02151 -0,28649 -0,31592 -0,01466 -0,19057 -0,1632 -0,34433 -0,30799 -1,04377 -0,83099 -0,1269 -0,22065 -0,25705 -0,69029 -0,85264 -0,99271 0,076046 0,228433 KEGG_Protein_digestion_and_absorption_Main_P -1,9537 -0,72266 1,07642 -7,69536 -2,7634 -3,88901 -3,81382 -5,6622 0,459239 1,548735 -4,20964 -1,14212 1,064342 1,449439 0,910694 16,39823 12,59445 9,701853 0,075885 0,228433 NCI_Integrin_linked_kinase_signaling_Pathway_(c 0,151351 0,008911 0,060832 0,676246 1,198672 0,63884 -1,55348 -1,66352 -1,95235 -0,67003 1,328955 0,937027 -0,07929 0,470753 -0,19941 -3,29136 -2,93308 -2,13328 0,076047 0,228433 NCI_TCR_signaling_in_naive_CD4_T_cells_Pathwa -0,1748 -0,0129 0,155793 0,464299 -0,23226 0,254445 -0,08446 -0,42525 0,277788 1,665838 0,170809 0,181639 -0,10207 -0,28845 0,380247 1,336726 1,012796 0,840503 0,075984 0,228433 NCI_Nectin_adhesion_Pathway_(positive_regulati 0,089682 -0,08289 -0,0833 -0,2969 -0,43359 -0,12548 -0,22084 -0,13221 -0,39283 -1,52774 -0,54583 0,013443 -0,13741 0,151633 -0,03562 -1,49787 -0,95935 -0,747 0,076122 0,228439 biocarta_role_of_erk5_in_neuronal_survival_Mai -0,17996 -0,49743 -0,41554 -0,63875 -0,14506 -0,15626 -2,79169 -2,78783 -3,26349 -1,3348 0,889759 0,097683 0,532949 -0,19434 0,572437 -4,56865 -2,15832 -2,18532 0,076204 0,228464 KEGG_Influenza_A_Main_Pathway -0,434 0,477631 0,668226 2,586087 -1,36022 1,232958 1,931428 1,055944 3,155396 2,756306 0,462822 -3,04057 -2,20386 -1,99918 -3,00026 5,558758 5,253877 3,808126 0,076476 0,228732 protein_iOi-iNi-acetyl-glucosylation -0,04264 -0,00943 -0,01213 -0,06382 -0,10961 -0,0827 -0,21874 -0,2315 -0,1356 0,164477 0,017504 0,123304 0,115947 0,113467 0,087017 0,559657 0,45875 0,326524 0,076482 0,228732 reactome_Folding_of_actin_by_CCT_TriC_Main_P 0,247347 0,04363 0,11163 -0,03596 -0,24846 -0,59442 -0,21603 0,055391 -0,59294 -1,00635 -0,02533 -0,24978 0,055775 0,201244 0,213077 -4,28375 -3,32507 -2,98697 0,076513 0,228732 biocarta_regulation_of_eif2_Main_Pathway 0,219854 0,206324 0,092769 -0,53229 -0,04407 -0,28199 0,393359 0,364189 -0,26471 -0,22737 -1,89212 -0,20491 -0,66142 0,332077 0,281959 -3,8613 -2,76751 -2,8702 0,077292 0,230616 Lipoxins_Influence_on_Neutrophil_Chemotaxis 0,057417 -0,23627 -0,1882 -0,13169 -0,36124 -0,57616 -0,048 0,044426 -0,51029 -1,52551 -0,45015 -0,11609 -0,28904 -0,15909 -0,20779 -2,48259 -1,81266 -1,47444 0,077289 0,230616 NCI_IL6_mediated_signaling_events_Main_Pathw 0,049771 -0,31845 -0,38739 -1,32163 -0,10526 -0,22224 0,478204 0,545585 -0,06448 -0,74228 -0,75337 -0,87397 0,212887 0,669991 0,789012 -1,6116 -1,11898 -0,64292 0,077643 0,231443 reactome_Adrenaline_noradrenaline_inhibits_ins -0,21542 -0,19717 -0,40469 2,125292 2,00023 0,883294 -0,1357 -0,43374 -0,10883 -1,68803 1,238367 0,586381 -0,62505 -0,53212 -0,59801 -2,49565 -2,77102 -1,42111 0,07796 0,232167 IL-10_Pathway_Translational_Modulation 0,238738 -0,20108 -0,13268 -0,70324 -1,28077 -1,19813 -0,41374 -0,22342 -0,30148 0,796029 0,719586 0,416691 0,153158 -0,26194 -0,08812 -0,77578 -0,47294 -0,31749 0,078072 0,232278 NCI_S1P4_Main_Pathway 0,146635 -0,20093 -0,17484 0,599229 -0,28752 -0,07449 -0,31933 -0,17354 -0,38516 -0,50373 0,890097 -0,7331 -0,04852 -0,35626 0,076691 -2,98967 -3,23849 -2,588 0,078168 0,232342 reactome_CDK_mediated_phosphorylation_and_ 1,856037 0,77427 0,70655 0,16798 0,60454 -2,38825 1,667938 2,121202 -1,08097 -3,17493 0,571798 0,300571 0,957878 1,502742 1,871675 -22,8293 -18,7868 -15,8599 0,078289 0,232478 reactome_SCF_beta_TrCP_mediated_degradation 1,875388 0,70138 0,558559 -0,00848 0,113035 -3,31287 1,035939 1,548848 -1,68792 -4,26638 0,024451 -0,43764 0,719042 1,251116 1,741846 -22,1994 -18,3607 -15,1385 0,078571 0,232872 reactome_Vif_mediated_degradation_of_APOBEC 1,906543 0,836046 0,730805 -0,12787 0,372589 -2,12004 0,410703 0,960109 -2,4099 -3,78303 0,35258 -0,11754 0,796179 1,16189 1,549178 -23,1488 -18,8502 -15,9757 0,078554 0,232872 CDP-diacylglycerol_biosynthesis 0,000849 -0,26694 -0,32255 -0,81611 -0,87683 -1,81528 0,126945 0,95662 -0,79374 -1,20678 -0,8821 -1,56593 -0,18807 0,002131 0,986515 -4,65723 -3,72895 -3,19427 0,078691 0,233006 KEGG_Fanconi_anemia_Main_Pathway 0,482206 0,497431 0,42763 -0,46556 -0,75164 0,675683 -0,97171 -1,1957 -1,35133 -1,11428 -0,91432 0,396912 0,957426 1,325442 1,351774 -2,03712 -0,38615 -1,14415 0,078866 0,233083 reactome_Translocation_of_ZAP_70_to_Immuno -0,86986 0,445125 0,130456 -0,31768 1,089813 2,025019 0,137075 -0,58777 1,729652 0,780649 0,963205 1,967407 -0,36212 -0,36168 -0,45223 4,695311 3,46817 4,271582 0,078866 0,233083 biocarta_sonic_hedgehog_receptor_ptc1_regulat 0,049736 -0,01727 -0,1107 -0,38733 0,255899 -0,13706 0,591611 0,796348 0,410082 -1,39056 -0,49593 -1,16419 -0,39057 -0,35857 -0,48555 -1,17096 -0,74427 -0,86392 0,079135 0,233248 KEGG_Adherens_junction_Main_Pathway -0,1498 0,433183 0,393865 0,093615 -1,18327 -1,40771 3,331061 2,804931 3,804696 0,269146 -0,52487 0,033412 -1,01061 0,483233 0,576077 1,837319 1,274135 0,499706 0,079285 0,233248 KEGG_Legionellosis_Main_Pathway -0,03115 -0,08749 0,021318 -0,91599 -0,07428 -0,47035 -1,79821 -1,92913 -1,75313 1,541216 0,444051 1,115102 -0,19724 -0,80294 -0,12203 -0,30634 -1,1615 -0,16278 0,079447 0,233248 KEGG_Porphyrin_and_chlorophyll_metabolism_M 0,08213 0,004826 0,019818 -0,23474 0,162772 0,604072 -0,32856 -0,30977 -0,80689 0,60394 0,525145 0,790881 0,850538 0,458363 0,701581 -1,69467 -1,9471 -3,04271 0,079286 0,233248 NCI_CXCR3_mediated_signaling_events_Pathway_ -0,37897 0,033928 0,245171 0,386395 0,43604 0,123947 0,919018 1,036117 1,082888 1,467191 0,983628 -0,1969 -0,68606 -0,31925 -0,05247 1,387399 1,963282 0,043103 0,079394 0,233248 NCI_CXCR3_mediated_signaling_events_Pathway_ -0,37897 0,033928 0,245171 0,386395 0,43604 0,123947 0,919018 1,036117 1,082888 1,467191 0,983628 -0,1969 -0,68606 -0,31925 -0,05247 1,387399 1,963282 0,043103 0,079394 0,233248 reactome_ER_Phagosome_Main_Pathway 2,217647 1,055795 0,860299 -0,08922 -0,51849 -2,15805 0,042692 0,684948 -2,8544 -3,24437 1,118977 -0,12538 1,852107 1,791657 2,870009 -29,4899 -24,2067 -19,9622 0,0794 0,233248 biocarta_akt_signaling_Pathway_(apoptosis) -0,03718 -0,10918 -0,15991 0,241786 1,124777 0,897134 0,051193 -0,10285 -0,02161 -0,30303 0,367827 0,14429 0,14373 0,195925 0,176731 0,077084 0,324008 0,309884 0,079714 0,233373 biocarta_akt_signaling_Pathway_(cell_survival) -0,03718 -0,10918 -0,15991 0,241786 1,124777 0,897134 0,051193 -0,10285 -0,02161 -0,30303 0,367827 0,14429 0,14373 0,195925 0,176731 0,077084 0,324008 0,309884 0,079714 0,233373 reactome_Interferon_gamma_signaling_Main_Pa 0,311676 0,00859 -0,08153 0,235842 -0,07291 0,22869 -0,48862 -0,17727 -0,87573 -0,12674 -0,22614 -1,39832 0,144574 0,073578 0,275624 -0,63656 0,004542 0,247394 0,079652 0,233373 biocarta_keratinocyte_differentiation_Pathway_(k 0,037014 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ATM_Pathway 0,301022 -0,52983 -0,60015 3,091113 2,978566 1,981373 -0,77665 0,162865 -1,83674 1,193389 1,259922 0,969679 -0,05727 -0,30965 0,564131 -2,95349 -0,1858 -0,0898 0,085034 0,241458 FLT3_Signaling_Pathway -0,21982 -1,29766 -0,97159 -0,10682 -0,77011 -1,49406 -3,34215 -2,13179 -4,81653 -2,05602 2,538282 2,168187 0,851641 0,915271 2,317535 -11,3918 -8,27308 -7,84866 0,085309 0,241579 reactome_Calnexin_calreticulin_cycle_Main_Path 0,066637 -0,00516 -0,02146 0,241525 0,178255 0,149482 -0,06915 -0,00981 -0,18502 -0,29739 0,082026 0,422452 -0,06915 -0,13049 -0,02626 -2,20771 -1,8711 -1,49078 0,08524 0,241579 reactome_S6K1_mediated_signalling_Main_Pathw 0,072709 -0,04385 0,039261 0,317242 0,128058 -0,05767 0,254676 0,331268 0,056672 0,029256 0,590119 0,205338 0,154729 0,260169 0,440841 -0,92275 -0,63649 -0,307 0,085172 0,241579 reactome_Signaling_by_constitutively_active_EGF 0,036076 -0,21634 -0,28064 -0,50008 -0,20122 -0,59702 -0,05177 0,064832 -0,58871 -1,2603 0,481573 -0,76915 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-23,4158 -19,0404 -16,2228 0,086602 0,242812 reactome_SLBP_independent_Processing_of_Hist 0,59046 0,206315 0,00227 0,327078 0,476781 0,161544 0,10681 0,438752 -0,52717 -0,23132 -0,45934 0,276446 0,064383 -0,19899 -0,19704 -2,92346 -3,07877 -1,80913 0,086542 0,242812 KEGG_cAMP_signaling_Main_Pathway -1,7422 0,033911 0,214333 -0,99811 0,65825 -2,70687 -0,23681 0,438152 -0,88259 3,853473 -1,64297 6,521342 2,794511 2,111208 2,322201 11,71226 11,73096 14,9019 0,087057 0,243461 MAPK_Signaling_Pathway_Gene_Expression_Apo 0,037501 -0,11013 -0,14304 -0,81094 0,291877 -0,18732 -0,45833 -0,02745 -0,70164 -0,31628 0,687621 -0,76308 0,446948 -0,04198 0,548305 -2,50907 -1,64063 -1,39759 0,08713 0,243461 reactome_Dual_incision_reaction_in_TC_NER_Ma 0,700794 -0,11602 -0,41208 -0,16393 0,108348 0,079768 -1,76792 -0,52666 -3,0997 -1,67484 -0,26318 1,70728 -0,08594 0,235162 -0,01056 -9,97227 -8,61075 -6,82121 0,087146 0,243461 reactome_Formation_of_transcription_coupled_N 0,700794 -0,11602 -0,41208 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0,08824 0,245638 biocarta_protein_kinase_a_at_the_centrosome_M -0,11091 -0,2032 -0,30331 0,013502 -0,0645 -0,29355 -0,44006 -0,30822 -0,89559 -0,57756 0,250669 -0,66756 -0,60138 -0,48509 -0,08819 -4,22709 -3,4615 -2,7622 0,088642 0,245781 biocarta_role_of_nicotinic_acetylcholine_recepto -0,03634 0,060886 -0,09341 -0,60532 0,107733 -0,95837 -0,5162 -0,74121 -0,3476 0,325816 1,104317 0,216109 0,120052 0,183668 0,362108 0,23236 0,476897 0,886031 0,088597 0,245781 KEGG_RIG_I_like_receptor_signaling_Main_Pathw 0,675468 -0,37286 -0,15904 -0,67946 -0,04142 0,04906 -3,18529 -2,22536 -3,6319 0,635144 -0,96715 -0,09533 0,257617 -0,14878 0,402043 -5,50593 -5,4519 -3,94025 0,088403 0,245781 NCI_ErbB1_downstream_signaling_Pathway_(ruff -0,01104 -0,17311 -0,23905 -0,29476 -0,98205 -1,24435 -1,3205 -1,19733 -1,88511 -1,90599 -0,09233 -0,90477 -0,11792 -0,23967 0,30246 -6,92429 -4,96643 -3,57231 0,088686 0,245781 reactome_Activation_of_gene_expression_by_SR 0,548426 -0,25295 -0,1653 -0,57177 -1,44836 0,902722 2,522068 3,149408 1,107115 -1,43336 0,689211 -0,99138 -0,08277 -0,05716 0,778538 -9,64647 -6,13264 -4,55851 0,088663 0,245781 biocarta_nuclear_receptors_coordinate_the_activ -0,03879 -0,08939 -0,16076 -0,62089 -0,8366 -0,24524 -0,63531 -0,53197 -0,86351 -0,68183 -0,25012 -0,6017 0,345529 0,227064 0,415734 -2,25895 -1,04766 -1,33499 0,089019 0,245849 KEGG_Leishmaniasis_Main_Pathway 0,552298 -0,54011 -0,08233 -0,81738 0,647342 1,18324 -3,9178 -3,64739 -3,81462 -0,02785 -1,4327 -0,07687 0,287339 -1,11652 0,91034 -1,43491 -2,42221 -1,25563 0,088929 0,245849 NCI_LKB1_signaling_events_Pathway_(ATP_biosy 0,011165 -0,06708 -0,02383 -0,10642 0,125025 -0,41503 0,063348 0,099779 -0,04527 -0,49691 0,097978 0,342203 0,10256 0,404241 0,298525 -0,99969 -0,90329 -0,63176 0,089263 0,245849 NCI_LKB1_signaling_events_Pathway_(ATP_meta 0,011165 -0,06708 -0,02383 -0,10642 0,125025 -0,41503 0,063348 0,099779 -0,04527 -0,49691 0,097978 0,342203 0,10256 0,404241 0,298525 -0,99969 -0,90329 -0,63176 0,089263 0,245849 NCI_LKB1_signaling_events_Pathway_(Wnt_recep 0,011165 -0,06708 -0,02383 -0,10642 0,125025 -0,41503 0,063348 0,099779 -0,04527 -0,49691 0,097978 0,342203 0,10256 0,404241 0,298525 -0,99969 -0,90329 -0,63176 0,089263 0,245849 pentose_phosphate_pathway_oxidative_branch -0,0438 -0,12218 -0,06519 0,3801 -0,29094 -0,62079 -0,26242 -0,27931 -0,36224 0,04203 -0,07661 -0,33216 0,225909 0,105465 0,327619 -0,74479 -0,95114 -1,29349 0,088903 0,245849 reactome_Vpu_mediated_degradation_of_CD4_M 1,88007 0,778451 0,702484 -0,29925 -0,18231 -2,87834 0,521974 1,043055 -2,14222 -3,59379 0,540406 -0,05709 0,808216 1,242827 1,885146 -22,1265 -18,3403 -14,9813 0,089073 0,245849 NCI_Alpha_synuclein_signaling_Pathway_(Pathwa 0,039581 -0,03532 0,137248 0,235918 0,311121 -0,13081 -1,1386 -1,10291 -1,0912 -0,21792 0,346939 0,639754 -0,16275 -0,10129 -0,14078 1,145468 0,296075 0,315442 0,090001 0,245924 NCI_Alpha_synuclein_signaling_Pathway_(Pathwa 0,039581 -0,03532 0,137248 0,235918 0,311121 -0,13081 -1,1386 -1,10291 -1,0912 -0,21792 0,346939 0,639754 -0,16275 -0,10129 -0,14078 1,145468 0,296075 0,315442 0,090001 0,245924 NCI_Signaling_events_mediated_by_focal_adhesi 0,291439 -0,22254 -0,33002 -1,83854 -0,02142 -2,46871 -4,13689 -3,26101 -5,4844 -2,32907 0,129482 -0,11462 1,955057 1,704806 2,589533 -8,14625 -4,89205 -2,81727 0,089612 0,245924 NGF_Pathway_Neuronal_Survival -0,48897 -0,34086 -0,29636 0,401667 0,891914 0,74718 0,60346 1,044899 0,291105 1,442318 0,352746 1,343152 0,066929 0,034348 0,456969 -4,15876 -2,82987 -2,30817 0,090001 0,245924 reactome_Degradation_of_beta_catenin_by_the_ 2,283596 0,668413 0,644542 0,417216 -0,51486 -3,29057 -0,04593 0,754731 -3,33166 -3,28258 0,964686 -0,41912 1,061552 1,469859 1,889272 -26,0493 -21,4659 -17,3458 0,089569 0,245924 reactome_IRAK1_recruits_IKK_complex_Main_Pa 0,105255 -0,13445 -0,05676 0,108377 -0,56111 0,26156 -0,50491 -0,31212 -0,80769 -0,58223 -0,89856 -1,03202 0,466055 0,168478 0,468959 0,129825 -0,21728 0,36674 0,089911 0,245924 reactome_IRAK1_recruits_IKK_complex_upon_TL 0,105255 -0,13445 -0,05676 0,108377 -0,56111 0,26156 -0,50491 -0,31212 -0,80769 -0,58223 -0,89856 -1,03202 0,466055 0,168478 0,468959 0,129825 -0,21728 0,36674 0,089911 0,245924 reactome_Purine_catabolism_Main_Pathway 0,084165 0,32011 -0,1006 1,093149 0,388193 0,372485 -0,13784 -0,07284 -0,0402 -0,01413 -0,90128 0,336658 0,009822 -0,56854 0,044969 -0,87398 -0,99295 -0,68825 0,089931 0,245924 reactome_Vitamins_Main_Pathway -0,081 -0,03074 -0,10228 -0,94179 0,14142 0,418997 0,356186 -0,06546 0,290586 0,891016 0,552944 0,535827 0,323645 -0,1415 -0,10286 1,169256 0,307608 0,506347 0,089628 0,245924 NCI_Signaling_events_mediated_by_VEGFR1_and -0,10258 -0,2309 -0,15981 -0,3581 -0,45497 -1,70225 -1,47606 -1,30803 -1,59286 -0,02931 0,824702 0,351581 -0,15772 -0,56727 -0,04526 -0,62922 -0,24888 0,132396 0,090432 0,246454 PAK_Pathway_Lamelliopodia_and_Filopodia_Outg -6,36884 -1,87237 -0,91737 -10,6611 -3,69352 -10,6839 -8,77404 -12,9273 -1,18557 5,27824 -9,22688 -2,74083 0,237679 -0,10087 1,37655 20,65218 14,78112 13,48459 0,090282 0,246454 Target_drugs_pathway -0,73225 -1,1257 -1,30393 -4,71055 -1,28546 -7,63317 -9,17628 -11,2101 -10,1876 -5,31212 -6,83095 -1,37397 1,529617 -0,07807 2,213632 -17,0231 -13,326 -9,39576 0,090354 0,246454 NCI_N_cadherin_signaling_events_Pathway_(gap_ -0,04993 -0,12786 -0,01887 0,255838 0,504862 0,214975 0,477311 0,401832 0,164702 -0,15504 0,939482 0,155043 -0,11476 -0,19179 0,158569 -3,48687 -2,5645 -2,37265 0,090758 0,246909 reactome_Synthesis_secretion_and_deacylation_ 0,66839 -0,03177 -0,04825 -0,63973 1,123727 0,712132 -2,85332 -2,37823 -3,27795 -0,30276 0,014982 0,789283 -0,27214 0,561846 0,02385 -4,0589 -3,66059 -2,46623 0,090707 0,246909 NCI_p53_Pathway_(apoptosis) 0,556625 -0,21107 -0,28624 1,257214 1,420154 0,389832 -0,76289 0,098695 -2,25799 -0,38301 1,69391 0,518369 -0,75375 -0,18402 0,016337 -9,35947 -6,41235 -6,1478 0,090838 0,246913 NCI_Ephrin_A_reverse_signaling_Main_Pathway -0,07909 0,012739 -0,00722 -0,90928 -1,52127 -1,33145 -0,92673 -0,99716 -1,07472 0,543524 0,118009 0,926123 0,217022 0,437096 0,431902 0,020772 0,998924 0,531973 0,091702 0,248394 NCI_Ephrin_A_reverse_signaling_Pathway_(beta_ -0,07909 0,012739 -0,00722 -0,90928 -1,52127 -1,33145 -0,92673 -0,99716 -1,07472 0,543524 0,118009 0,926123 0,217022 0,437096 0,431902 0,020772 0,998924 0,531973 0,091702 0,248394 reactome_disassembly_of_the_destruction_comp -0,14925 -0,71816 -0,34291 0,549795 -0,49826 -0,49355 0,107838 0,328918 0,055315 -0,35177 1,116664 0,406968 0,830237 0,335571 0,425163 -2,58846 -1,46388 -1,20626 0,091525 0,248394 reactome_SLBP_Dependent_Processing_of_Replic 0,595288 0,182462 -0,00914 0,298038 0,464892 0,191636 0,242905 0,551192 -0,40887 -0,12604 -0,43157 0,286194 0,080711 -0,20026 -0,26707 -3,45704 -3,59295 -2,20491 0,09166 0,248394 reactome_Resolution_of_AP_sites_via_the_single -0,08326 -0,10044 -0,10044 -0,46235 -0,24783 -0,35411 0,251291 0,290618 0,088184 -1,00279 -0,21103 -0,53014 0,050922 0,188136 0,32239 -0,53221 -0,49064 -0,43274 0,091808 0,248464 cAMP_Pathway_Degradation_of_Cell_Cycle_Regu -0,56283 -0,24097 -0,14489 0,156149 1,698602 1,18519 -0,95884 -1,1209 -0,16716 0,926057 0,679504 1,101446 -1,11002 -0,78829 -0,9247 4,086037 3,547623 3,667398 0,091958 0,248655 biocarta_role_of_brca1_brca2_and_atr_in_cancer 0,362883 -0,07883 -0,10598 0,909184 1,007714 0,693886 0,636387 1,438212 -0,56965 0,815006 0,466118 -0,1413 -0,30835 -0,02331 -0,16373 -5,26807 -2,46511 -2,18934 0,092235 0,249187 NCI_C_MYB_transcription_factor_network_Main_ -0,47355 -0,57451 -0,53488 -1,35522 -0,23947 -1,16116 -2,04599 -2,01518 -2,75114 0,129541 0,601263 -0,66083 0,631782 1,109733 0,988264 -4,33811 -3,8479 -2,31329 0,092533 0,249774 biocarta_role_of_egf_receptor_transactivation_by -0,19385 -0,43184 -0,39591 0,06088 -0,1902 -0,80792 -0,2923 -0,03063 -0,63553 -1,18687 -0,03088 0,161734 -0,02362 -0,29797 0,180769 -1,52548 -1,04526 -0,86079 0,092972 0,249876 NCI_TNF_receptor_signaling_pathway__Pathway_ 0,068314 -0,028 -0,15954 -0,61773 -0,08766 -1,67885 -2,13356 -1,80783 -2,27798 -1,8923 -0,62639 -1,73428 0,62802 0,443881 0,491533 -2,21853 -1,41655 -0,90111 0,092769 0,249876 reactome_Scavenging_by_Class_B_Receptors_Ma -0,09737 -0,01622 0,144689 0,209126 0,2727 0,253292 0,22843 0,105699 0,482878 0,638405 0,510321 0,098372 -0,21768 -0,08919 -0,41891 0,680884 0,388145 0,169945 0,092873 0,249876 reactome_Signaling_by_FGFR1_fusion_mutants_M 0,08847 -0,07079 -0,17974 -0,55473 0,115909 -0,38135 -0,11253 0,30077 -0,68395 -0,68892 -0,24035 0,480716 0,185121 0,048858 0,265486 -3,35105 -2,34467 -1,79148 0,092966 0,249876 UTP_and_CTP_dephosphorylation_II 0,057171 -0,05204 0,008941 -0,40533 -0,4578 -0,40395 0,985983 1,105974 0,824656 -0,83856 -1,39256 -0,11665 0,268845 0,648157 0,550347 -0,90916 -0,36535 -0,55045 0,092824 0,249876 Cytokine_Network_Pathway 1,200634 1,110728 1,505894 -1,83924 1,167263 -3,19184 0,861777 -0,43923 2,473116 2,579422 1,670353 3,278213 1,512841 2,415727 2,415074 5,149672 4,191444 1,63317 0,093582 0,250437 NCI_CDC42_signaling_events_Main_Pathway -0,07266 -0,2501 -0,65241 -1,32951 -1,4675 -1,76963 -2,80824 -1,92771 -4,62545 -1,78453 0,356846 0,304154 0,51966 0,991943 1,817331 -13,2255 -9,33571 -7,12086 0,09354 0,250437 NCI_Fanconi_anemia_Pathway_(G1_S_transition_ 0,08103 -0,06303 -0,05072 0,319203 0,533876 0,470666 -0,1071 0,140621 -0,44573 -0,50765 0,463648 0,255109 -0,28188 -0,13012 -0,16791 -1,7341 -1,14939 -0,77292 0,093299 0,250437 reactome_Conjugation_of_salicylate_with_glycine -0,13522 0,0725 0,067356 -0,33724 0,442314 0,53277 0,834569 0,972252 0,97696 1,473226 0,165938 0,433134 0,263256 -0,18536 -0,32265 1,874462 0,985781 0,28655 0,093441 0,250437 TNF_Signaling_Pathway 0,255449 -0,42069 -0,36541 -0,37504 -0,82885 -1,95845 -4,13428 -2,91055 -5,68567 0,551314 -2,41733 -1,45543 -0,0032 0,478311 -0,32755 -8,0118 -6,07948 -4,48719 0,093368 0,250437 reactome_Synthesis_of_PIPs_at_the_late_endoso 0,225106 -0,00364 -0,08398 -0,25085 -0,69579 -0,26927 -0,31624 0,005313 -0,62656 -3,11667 -1,58069 -0,53796 0,163384 0,720397 0,359469 -1,16926 -0,29811 -0,1207 0,093801 0,250806 KEGG_Viral_carcinogenesis_Main_Pathway 1,289553 -0,65916 -1,20437 -4,56745 -3,67582 -5,759 0,29636 2,384663 -3,29989 -2,01863 -4,08268 -6,38934 0,088298 -0,89064 3,521927 -32,9865 -25,2826 -18,9192 0,093996 0,251114 KEGG_TGF_beta_signaling_Main_Pathway 0,427831 -0,26468 -0,48648 3,30158 2,652977 1,756966 2,28521 2,690491 -0,17065 1,735556 2,343054 2,457586 0,44984 -0,05071 -0,30671 -4,78038 -5,28745 -3,57167 0,094698 0,252341 NCI_LPA_receptor_mediated_events_Pathway_(p -0,01217 -0,08563 -0,01472 0,127948 -0,01568 -0,05222 0,09574 0,241798 0,054072 -0,21187 0,185783 -0,30484 0,170284 0,180061 0,13414 0,081077 0,014293 0,101936 0,094575 0,252341 reactome_Downregulation_of_ERBB4_signaling_M0,205415 0,0443 0,020393 -0,33018 0,328868 -0,17471 0,208449 0,378966 -0,12941 -0,40544 0,176507 0,032367 0,10826 0,072442 0,094417 -3,80951 -2,68919 -2,11078 0,094699 0,252341 Interferon_Pathway_Gene_Expression_via_HIST1 0,514799 -0,45737 -0,1544 0,852574 1,220849 0,440724 2,392738 2,932912 1,594128 1,539519 1,207515 -0,93237 0,413551 -0,80211 1,111385 -2,29169 -1,67691 -1,5926 0,094924 0,25251 Ras_Signaling -0,2669 -0,47794 -0,16685 -2,80481 0,118656 -2,23521 -5,89125 -6,10332 -5,96512 1,846873 -1,36562 0,500894 0,05959 -0,10609 -0,15652 0,094425 1,258683 1,60999 0,094859 0,25251 KEGG_Colorectal_cancer_Main_Pathway -0,31045 -0,45717 -0,65919 0,05294 1,055926 0,321885 -0,69389 -0,11215 -1,71053 1,385643 1,076457 0,911366 -0,05264 0,558616 0,461711 -5,59817 -3,44722 -2,95039 0,095338 0,253178 reactome_Inhibition_of_replication_initiation_of_ 0,178895 -0,00068 0,119702 0,186079 0,544293 -0,13246 2,101665 2,365864 1,527113 -0,73982 -0,29926 -0,57898 -0,61619 -0,60678 -0,44961 -4,0153 -3,10217 -2,32045 0,095332 0,253178 GSK3_Signaling_Pathway_Gene_Expression_via_C 2,068004 1,09778 0,751708 -0,80354 0,483725 -0,94606 0,970376 0,943176 -1,04791 -1,464 0,446448 0,889622 1,327826 1,771546 1,677008 -14,8561 -11,857 -9,37962 0,095599 0,253183 histamine_biosynthesis -0,16112 -0,10034 -0,03763 0,384757 -0,00243 0,01318 0,012872 0,059099 0,053889 0,184592 -0,03268 -0,34116 0,028233 0,016241 0,044741 -0,28464 0,178521 -0,06845 0,095748 0,253183 KEGG_Cardiac_muscle_contraction_Main_Pathwa 0,170934 -0,08027 0,030474 -0,86632 -1,60547 0,112074 -0,71645 -1,13175 -0,82643 0,152625 0,186539 -0,52557 -0,26101 0,036802 -0,19698 0,304375 0,278931 0,314753 0,095828 0,253183 L-dopachrome_biosynthesis 0,02499 0,005789 0,057236 -0,21735 -0,02654 -0,05853 -0,02336 -0,02569 0,030678 0,608155 -0,11543 -0,05783 0,003667 0,046102 0,05641 0,328428 0,19633 0,051255 0,095613 0,253183 reactome_temp_Nuclear_Receptor_transcription_ -0,90683 -0,27195 -0,67324 -4,01338 -1,55961 -2,97626 -0,03597 -0,85459 0,003059 -1,84508 0,043681 -0,10244 -0,75169 -1,48493 0,226031 0,035869 0,457472 -0,90252 0,095704 0,253183 S-reticuline_biosynthesis 0,02499 0,005789 0,057236 -0,21735 -0,02654 -0,05853 -0,02336 -0,02569 0,030678 0,608155 -0,11543 -0,05783 0,003667 0,046102 0,05641 0,328428 0,19633 0,051255 0,095613 0,253183 reactome_FGFR1b_ligand_binding_and_activation -0,13785 -0,11372 -0,06774 -0,16891 0,523033 0,150733 -0,4234 -0,44138 -0,13375 0,111627 -1,10247 0,037021 -0,00341 -0,46393 0,041672 -0,4358 -0,67032 -0,55994 0,096063 0,25359 reactome_Oxidative_Stress_Induced_Senescence 0,151529 -0,54929 -0,72878 -3,12699 -2,01536 -2,4821 0,265811 0,988049 -1,39067 -3,84993 -0,42908 -1,47661 2,298041 1,654019 1,545809 -7,71914 -6,27807 -4,74701 0,09645 0,254395 Ras_Pathway_CDC42_Pathway 0,03253 -0,10284 -0,18186 0,452262 0,478045 0,538365 -0,13858 -0,05065 -0,41134 -0,02634 0,222275 0,486889 -0,14078 0,039149 -0,26831 -1,53588 -1,00644 -0,3312 0,09665 0,254608 reactome_cGMP_effects_Main_Pathway -0,19966 0,421205 0,039357 -1,82126 -1,08611 -2,3672 -0,25868 -0,22897 0,078137 1,548701 -0,54791 -0,3164 0,89589 1,177527 0,998033 3,982035 2,960566 2,722992 0,096694 0,254608 KEGG_Pyruvate_metabolism_Main_Pathway 0,484742 0,338526 0,200072 -0,72512 -0,39785 -2,57341 1,665044 2,214079 1,122211 -1,83257 1,043977 -0,90729 0,875074 1,515012 1,010592 -9,19595 -9,04094 -6,87853 0,097125 0,25516 reactome_Synthesis_of_PE_Main_Pathway -0,0589 -0,0233 -0,07976 0,011683 0,407178 -0,0585 -0,63447 -0,51747 -0,58154 -0,04089 -0,13202 -0,18909 -0,84101 -0,69229 -0,33871 0,355153 1,154775 0,785212 0,097149 0,25516 trehalose_degradation -0,0913 -0,05113 -0,10243 -0,50902 -0,13308 -0,37684 0,570572 0,543422 0,530418 0,082651 0,079305 -0,35364 -0,05387 0,162606 0,00768 0,979694 0,607444 0,231569 0,097039 0,25516 EGF_Pathway_Rab5_Regulation_Pathway 0,021027 0,074954 0,007466 0,251296 0,266557 0,212586 0,512224 0,521773 0,40457 -0,25716 0,230509 -0,52932 -0,20315 -0,02516 -0,05562 -0,32018 -0,19611 -0,1564 0,097662 0,256075 reactome_Regulation_of_gene_expression_by_Hy -0,09425 -0,12545 -0,17677 -0,48407 -0,13898 -0,5892 -0,61496 -0,74744 -0,94966 0,08547 -0,23639 -0,07843 0,434028 0,194966 0,475564 -1,89279 -1,68337 -0,98646 0,097612 0,256075 Transport_between_Cytoplasm_and_Mitochondr -0,02382 -0,07768 -0,01629 0,033951 0,48783 -0,01468 -0,43238 -0,41848 -0,63983 -0,18765 -0,30385 0,266153 0,266218 0,095046 -0,08461 -0,1964 -0,04118 0,052876 0,097812 0,256253 reactome_Synthesis_of_Prostaglandins_PG_and_ 0,015673 0,186838 0,147651 -2,34327 -1,04281 -2,24066 -0,73295 -0,90589 -0,66599 0,284722 0,547559 0,657079 0,395449 0,004941 1,109802 1,166187 1,141177 0,368417 0,098026 0,256598 biocarta_trka_receptor_signaling_Pathway_(cell_g 0,036844 -0,01723 -0,07572 -0,17332 0,72482 0,320766 -0,08537 -0,07371 -0,3174 0,395064 0,425208 0,322089 0,212651 0,160115 0,201692 -1,36902 -0,70657 -0,58663 0,098579 0,256733 NCI_IFN_gamma_Pathway_(Antibacterial_Respon 0,267972 -0,00782 -0,15235 -0,12461 -0,26529 -0,01588 -0,00085 0,338265 -0,42712 -1,42863 -0,0962 -1,39375 -0,06271 -0,12058 0,322483 -2,03719 -0,75858 0,32423 0,098737 0,256733 NCI_IFN_gamma_Pathway_(antigen_processing_a 0,267972 -0,00782 -0,15235 -0,12461 -0,26529 -0,01588 -0,00085 0,338265 -0,42712 -1,42863 -0,0962 -1,39375 -0,06271 -0,12058 0,322483 -2,03719 -0,75858 0,32423 0,098737 0,256733 NCI_IFN_gamma_Pathway_(antigen_processing_a 0,267972 -0,00782 -0,15235 -0,12461 -0,26529 -0,01588 -0,00085 0,338265 -0,42712 -1,42863 -0,0962 -1,39375 -0,06271 -0,12058 0,322483 -2,03719 -0,75858 0,32423 0,098737 0,256733 NCI_IFN_gamma_Pathway_(Antiviral_Response) 0,267972 -0,00782 -0,15235 -0,12461 -0,26529 -0,01588 -0,00085 0,338265 -0,42712 -1,42863 -0,0962 -1,39375 -0,06271 -0,12058 0,322483 -2,03719 -0,75858 0,32423 0,098737 0,256733 NCI_IFN_gamma_Pathway_(apoptosis) 0,267972 -0,00782 -0,15235 -0,12461 -0,26529 -0,01588 -0,00085 0,338265 -0,42712 -1,42863 -0,0962 -1,39375 -0,06271 -0,12058 0,322483 -2,03719 -0,75858 0,32423 0,098737 0,256733 NCI_IFN_gamma_Pathway_(Immunoregulation) 0,267972 -0,00782 -0,15235 -0,12461 -0,26529 -0,01588 -0,00085 0,338265 -0,42712 -1,42863 -0,0962 -1,39375 -0,06271 -0,12058 0,322483 -2,03719 -0,75858 0,32423 0,098737 0,256733 NCI_IFN_gamma_Pathway_(negative_regulation_ 0,267972 -0,00782 -0,15235 -0,12461 -0,26529 -0,01588 -0,00085 0,338265 -0,42712 -1,42863 -0,0962 -1,39375 -0,06271 -0,12058 0,322483 -2,03719 -0,75858 0,32423 0,098737 0,256733 heparan_sulfate_biosynthesis -0,93713 -0,61057 -1,01327 1,520653 -2,47589 -0,31099 -0,41412 -0,24616 -0,52454 -1,32971 -0,67354 -0,6808 1,147929 -0,14235 1,21125 -0,937 -1,3703 -2,23179 0,098875 0,256877 reactome_CRMPs_in_Sema3A_signaling_Main_Pa -0,09333 -0,17099 -0,22267 -0,00858 0,030106 -0,493 -3,65196 -3,5893 -4,12024 -1,72123 -1,13363 -0,65175 0,258545 0,14877 0,210456 -0,24293 -0,40625 0,727028 0,099253 0,257643 2-oxobutanoate_degradation 0,284915 0,23801 0,110633 -0,35579 -0,08359 -0,10635 0,253075 0,506532 -0,40604 -0,04341 0,521085 -0,27647 0,04386 0,242976 0,68689 -4,62279 -4,0348 -3,69364 0,099451 0,257944 NCI_ErbB1_downstream_signaling_Pathway_(lam 0,057037 0,090769 0,190948 0,346145 -1,31081 -0,50895 0,752229 0,82217 1,005877 -0,3021 -0,67326 0,428064 0,09536 -0,14522 0,068751 1,691601 0,86399 0,920743 0,099768 0,258551 Akt_Signaling_Pathway_Glycogen_Synthesis_and_ 0,0047 -0,04736 0,346364 -0,65453 0,362012 -1,19283 0,216119 0,156849 0,399195 0,230058 1,234605 -0,34303 0,283455 0,267537 0,066147 0,318709 1,133311 1,062286 0,099975 0,258871 NCI_CDC42_signaling_events_Pathway_(actin_cyt -0,26405 -0,24817 -0,37419 -0,22253 -0,5069 -0,6094 -2,38553 -2,2793 -2,42361 -1,01642 0,58639 -0,65301 -0,08395 -0,22905 0,11201 -2,91838 -2,05594 -1,46146 0,100357 0,259482 NCI_EPO_signaling_Main_Pathway -0,37619 -0,3697 -0,49864 -0,78317 0,148655 -0,39579 -2,03808 -2,08749 -2,46629 -1,09283 0,280603 0,512473 -0,53758 -0,26449 0,115584 -5,46351 -4,07039 -3,87321 0,100377 0,259482 KEGG_Other_types_of_O_glycan_biosynthesis_M -0,46487 -0,60544 -0,54084 0,095725 0,256369 1,510894 -0,9111 -0,52606 -1,5466 2,235183 1,805979 -0,07095 0,574762 -0,25556 1,188513 -2,39423 -5,00852 -3,20543 0,100935 0,259885 NCI_Endogenous_TLR_signaling_Pathway_(regula -0,32409 -0,17398 -0,24713 -0,40084 0,323502 -0,24391 -2,82854 -2,67452 -2,6938 2,34904 1,368383 1,031301 -1,02903 -1,11974 -0,5697 -0,55166 -0,60145 -0,70804 0,101219 0,259885 NCI_Endogenous_TLR_signaling_Pathway_(regula -0,32409 -0,17398 -0,24713 -0,40084 0,323502 -0,24391 -2,82854 -2,67452 -2,6938 2,34904 1,368383 1,031301 -1,02903 -1,11974 -0,5697 -0,55166 -0,60145 -0,70804 0,101219 0,259885 NCI_Endogenous_TLR_signaling_Pathway_(regula -0,32409 -0,17398 -0,24713 -0,40084 0,323502 -0,24391 -2,82854 -2,67452 -2,6938 2,34904 1,368383 1,031301 -1,02903 -1,11974 -0,5697 -0,55166 -0,60145 -0,70804 0,101219 0,259885 NCI_IL1_mediated_signaling_events_Main_Pathw 0,295541 -0,38444 -0,21978 0,9554 1,192051 -0,35842 -1,95478 -1,48483 -2,80584 0,993191 0,975312 0,689061 0,558538 0,270795 0,151335 -2,13311 -2,6272 -1,6559 0,100975 0,259885 NCI_IL8_and_CXCR1_mediated_signaling_events_ -0,14873 -0,13398 0,118017 -0,23717 0,22579 -0,04209 -2,18139 -2,52572 -1,64571 1,110141 -0,14312 -0,72782 -0,63258 0,127942 0,375015 1,961409 2,34081 2,155764 0,101001 0,259885 PTEN_Pathway_Apoptosis 0,019592 -0,21292 -0,11634 1,084475 -0,25968 -0,06193 -0,16136 -0,47467 0,152907 0,964161 -0,25698 -0,1534 -0,43106 -0,54668 -0,60641 1,79584 1,522736 1,238216 0,101284 0,259885 reactome_Hedgehog_ligand_biogenesis_Main_Pa 1,710887 0,658509 0,424037 -1,1835 0,409808 -2,7658 1,010292 1,402462 -1,47731 -2,42314 0,679691 0,471512 0,901122 0,784127 1,747407 -22,9959 -19,0276 -15,8672 0,100789 0,259885 reactome_Transport_of_fatty_acids_Main_Pathw -0,06188 -0,1522 -0,10951 -0,0643 -0,10232 0,318033 -0,13357 -0,18887 -0,05811 0,897616 0,345275 0,270119 -0,04464 -0,22602 -0,06155 0,560623 0,346498 -0,1079 0,100834 0,259885 reactome_TRAF6_mediated_IRF7_activation_in_T -0,06988 -0,11339 -0,13324 0,57208 0,859666 0,144991 -1,10758 -1,04015 -1,42347 0,334861 0,910532 0,131837 0,011033 -0,11028 -0,03527 -1,63478 -1,32705 -1,03618 0,101452 0,260102 Erythropoietin_Pathway_GPI_Hidrolysis_and_Ca2 -0,17241 0,081909 0,008897 -0,34506 -0,00994 -0,3467 0,105313 0,157503 0,386277 0,360292 0,270526 -0,14547 -0,06013 -0,43801 -0,30959 -0,47047 -0,00966 -0,36277 0,101716 0,260564 tryptophan_degradation -0,08983 0,104197 0,233325 -0,83311 -1,01542 -0,39682 -1,65616 -2,11402 -1,42552 -0,95939 -0,58097 -1,0754 0,077313 -0,79728 -0,63964 0,375181 1,159274 -0,10388 0,102129 0,261406 cAMP_Pathway_Metabolic_Energy -0,46233 -0,45347 -0,53799 1,993461 2,234162 2,165925 1,280656 1,537395 0,869449 0,006818 1,74019 2,353821 -0,78859 -0,44974 -0,00337 -4,59529 -3,69335 -1,66734 0,102238 0,261471 reactome_NCAM1_interactions_Main_Pathway -0,8731 -0,29786 -0,11411 -1,67445 -2,39821 -2,37199 -1,72298 -2,20667 0,126361 0,346997 -2,37956 -2,16906 0,596276 -0,70679 0,969429 7,750076 6,550261 6,379387 0,102492 0,261907 biocarta_phospholipids_as_signalling_intermediar 0,036617 -0,13556 -0,10237 0,238521 0,061386 -0,20809 0,331175 0,435178 0,031596 1,114358 0,195946 -0,85273 -0,27045 0,259449 0,185227 -3,59171 -3,49736 -2,1678 0,103033 0,26217 ILK_Signaling_Pathway_Actin_Polymerization_Cyt -0,02251 -0,02282 -0,07009 -0,55695 -0,14949 -0,85054 -1,90696 -2,13237 -2,04164 -1,15228 0,39209 0,46333 0,976934 1,004271 0,672407 -2,10059 -1,64088 -1,55452 0,102774 0,26217 KEGG_Primary_immunodeficiency_Main_Pathway -0,01521 0,769918 0,419643 -1,0325 0,937128 0,471164 2,316793 1,533215 4,708772 2,96651 1,342779 -2,52461 0,558952 -0,92182 0,526108 4,70467 2,927664 2,843131 0,103185 0,26217 NCI_Ephrin_B_reverse_signaling_Pathway_(angio -0,23105 -0,15547 -0,28193 0,375074 1,481115 0,225756 -2,1315 -2,33832 -1,91821 -0,41795 -0,66206 -0,41188 0,168142 0,15729 0,437955 1,133432 0,429428 0,409945 0,10307 0,26217 NCI_Ephrin_B_reverse_signaling_Pathway_(endot -0,23105 -0,15547 -0,28193 0,375074 1,481115 0,225756 -2,1315 -2,33832 -1,91821 -0,41795 -0,66206 -0,41188 0,168142 0,15729 0,437955 1,133432 0,429428 0,409945 0,10307 0,26217 reactome_Activation_of_PKB_Main_Pathway -0,0406 -0,06564 -0,11818 0,335371 0,620402 0,550841 -1,5023 -1,49121 -1,63484 0,638884 0,740665 0,189063 0,320157 -0,19154 0,129657 -0,8101 -1,17445 -0,57758 0,10307 0,26217 reactome_PKA_mediated_phosphorylation_of_CR -0,05236 -0,09582 -0,05305 -0,01753 0,072809 -0,31911 -0,12819 -0,03912 -0,16291 -0,17167 -0,40999 0,135532 -0,2541 -0,1573 0,139187 -1,34351 -1,04516 -0,76056 0,103147 0,26217 biocarta_regulators_of_bone_mineralization_Mai -0,01781 -0,0889 0,140181 -1,77415 -0,81777 -1,73219 1,102475 0,750746 1,170914 -0,64817 -0,53759 0,522222 -0,15394 0,201554 0,233603 0,917657 0,395197 0,156222 0,103323 0,262198 reactome_Ca_activated_K_channels_Main_Pathw -0,30134 -0,06801 -0,10288 -0,29247 0,08899 -0,45719 -0,71799 -0,78314 -0,26942 1,792295 0,163493 0,771302 0,68874 1,182697 0,630465 3,775293 2,962244 3,491239 0,103364 0,262198 mTOR_Pathway_Translation_Elongation 0,363685 0,134941 0,08697 -0,34114 0,043497 -0,64752 -0,07341 0,254242 -0,69984 -0,00973 -0,02445 -0,6677 0,129649 -0,0603 0,323443 -4,78974 -3,88294 -3,66323 0,103494 0,262315 NGF_Pathway_Neurite_Outgrowth_and_Different -0,5888 -0,49916 -0,32634 0,025919 0,974647 0,893486 0,046052 0,27944 -0,02388 1,559197 0,215773 2,162075 0,518729 0,276987 0,751941 -3,84273 -2,33188 -1,549 0,103758 0,262668 TGF-Beta_Pathway_Epithelial_Mesenchymal_Tran -0,32488 -0,23736 -0,24184 0,218646 0,228394 0,560306 0,50295 1,008533 0,1469 1,008053 -0,27383 1,290146 -0,18351 0,105393 0,462103 -3,65928 -2,70472 -1,98436 0,103802 0,262668 biocarta_apoptotic_signaling_in_response_to_dna 0,233497 0,084593 0,017156 0,03447 -0,05355 0,171369 -0,44556 -0,18759 -0,71636 0,837188 -0,59751 -1,03332 0,01028 -0,05788 -0,29776 -2,30166 -1,78898 -1,69971 0,103988 0,26271 reactome_Androgen_biosynthesis_Main_Pathway -0,32645 0,053156 -0,15166 0,548186 -0,03212 -0,13204 0,349984 0,085612 0,891162 1,797698 1,304023 0,373147 0,225329 -0,36725 0,078248 0,682727 0,4805 0,392143 0,103911 0,26271 Chromatin_Pathway 0,000624 -0,37135 -0,16675 0,07607 0,056531 -0,25766 0,365633 0,618467 -0,34146 -1,2015 0,794829 0,404875 -0,32442 0,069712 -0,10113 -5,05685 -3,50859 -2,62967 0,104176 0,262973 gamma-glutamyl_cycle 0,003621 0,000185 -0,05143 0,136756 0,097403 0,307142 -0,43185 -0,46682 -0,59081 0,262006 0,492348 0,702706 0,367848 0,472781 0,421705 -0,64336 -0,26744 -0,15448 0,104642 0,26368 NCI_Alpha4_beta1_integrin_signaling_events_Pat -0,09421 0,065369 -0,15754 -1,64401 -0,12757 -1,71171 0,308538 0,440974 0,205858 0,058836 0,614019 -0,09321 -0,34302 -0,29924 -0,0627 -0,80974 -0,05311 -0,12114 0,104548 0,26368 PTEN_Pathway_Neuronal_Survival -0,24036 0,189166 0,092994 0,247449 0,643576 0,018901 -0,85442 -0,89357 -0,53833 0,815516 0,000471 -0,4652 -0,05017 -0,29339 -0,22829 2,22297 2,055068 1,967067 0,10471 0,26368 heme_degradation 0,070861 -0,06439 -0,08849 0,551273 -0,17233 -0,33124 -0,45901 -0,36876 -0,38631 -0,15076 -0,12748 -0,86005 -0,10841 0,325053 -0,09131 -0,26236 -0,66235 -0,32594 0,104834 0,263779 KEGG_Proteoglycans_in_cancer_Main_Pathway -2,46792 -2,96356 -2,19412 -1,22548 -0,54436 -3,04829 -7,33226 -7,51648 -7,22763 -3,39775 2,796454 0,880009 0,943314 2,072909 1,642286 -9,24556 -3,6265 -1,40811 0,10531 0,264122 reactome_CREB_phosphorylation_Main_Pathway 0,086486 -0,22905 -0,17808 -0,40449 -0,88079 -0,5086 -0,8113 -0,56948 -1,17507 -1,34227 0,137474 -0,66518 -0,02819 0,258863 0,198502 -1,75617 -1,52742 -1,43227 0,105118 0,264122 reactome_Establishment_of_Sister_Chromatid_Co 0,466773 0,074808 0,090125 0,816315 0,352538 0,5329 2,256283 2,512923 1,212699 -1,32438 0,623947 -0,27205 -0,54472 -0,04307 -0,28747 -3,11162 -1,90738 -0,71962 0,105233 0,264122 reactome_Sialic_acid_metabolism_Main_Pathway 0,132412 -0,24515 -0,03888 0,455032 -1,01839 0,841511 -4,65714 -4,35067 -5,17131 0,068556 0,226298 0,3027 0,580833 0,662 0,372754 -1,94302 -1,41977 -0,23912 0,105219 0,264122 reactome_Synthesis_of_bile_acids_and_bile_salts -0,38557 0,002195 0,127838 -2,38757 -0,47207 -1,14447 -1,35526 -1,78522 -0,64434 -0,61277 0,114211 0,753703 1,14869 0,294317 0,412097 2,888594 2,874763 1,901514 0,105565 0,264549 Akt_Signaling_Pathway_Regulation_of_Na+_Trans 0,086324 -0,06935 0,021033 0,013769 0,527934 0,360053 -0,67008 -0,67876 -0,86323 -0,22839 -0,5893 -0,96809 -0,03061 0,155528 0,142381 0,198323 0,255448 0,390781 0,105879 0,264923 Chemokine_Ligand_2_Signaling -0,49608 -0,44319 -0,67677 0,253852 -1,83007 -0,26763 -2,46219 -2,50125 -2,8693 -1,6935 -1,85029 0,795198 -0,46272 -0,53148 -0,32421 -3,43641 -2,9814 -2,37839 0,106092 0,264923 reactome_Aflatoxin_activation_and_detoxification 0,128508 0,099754 -0,07126 -0,85229 -0,37103 -1,29467 0,040962 -0,35863 0,023135 0,667612 0,176738 0,953255 0,535854 0,498434 0,41428 1,019021 0,783449 0,446287 0,106036 0,264923 reactome_TRAIL_signaling_Main_Pathway -8,86E-05 -0,01219 0,021648 -0,41145 -0,38427 -0,76664 -0,9035 -0,77402 -0,68787 -0,4431 0,207656 0,660886 0,486441 -0,07853 -0,12112 0,535459 0,502113 -0,0355 0,106139 0,264923 tRNA_charging 0,846928 -0,15459 0,084043 -1,1971 -0,88116 -1,80458 -1,79126 -1,18364 -3,97659 -0,61648 0,031555 1,520309 0,990606 1,543084 1,485221 -16,5555 -13,9672 -11,3639 0,106001 0,264923 glutamine_degradationglutamate_biosynthesis -0,08577 0,108817 -0,007 -0,03345 0,110209 -0,03251 -0,51992 -0,46347 -0,5579 0,069017 -0,46165 -0,29718 0,165443 0,010045 -0,0097 -0,44748 0,017057 0,093368 0,106557 0,265754 Hypoxia_induced_EMT_in_cancer_and_fibrosis_3 -0,02415 -0,30301 -0,14619 -0,23066 0,281732 -0,11584 -1,95502 -1,75641 -1,6739 -0,15952 -0,06588 0,472655 0,261161 0,395719 0,130538 -0,00549 -1,18022 -0,25596 0,106915 0,26622 RhoB_Signaling -0,08265 -0,05047 -0,10115 -0,25948 0,584665 -0,49804 -0,85426 -0,8777 -0,87337 -1,12042 0,37888 -0,23517 0,182732 0,227583 0,490482 -0,57687 -0,19417 -0,43307 0,1069 0,26622 KEGG_AMPK_signaling_Main_Pathway 0,577424 -0,0332 0,708517 -5,46747 -4,82825 -3,65937 -1,37557 -1,18633 -1,26288 -3,459 -1,1838 -1,36756 -1,03791 -1,52251 -2,33058 -0,95967 -3,82479 -3,71923 0,107043 0,266326 NCI_Aurora_A_signaling_Pathway_(proteasomal_ -0,09003 0,01447 -0,08224 -0,18347 -0,33301 0,02873 0,947441 0,909111 0,900386 -1,467 -0,89948 -0,99278 -0,16011 -0,0716 -0,01724 -0,47433 0,022778 -0,14458 0,107245 0,266614 KEGG_Pancreatic_secretion_Main_Pathway 0,066985 -0,26843 0,204408 -0,59557 0,714466 -1,5001 -0,95436 -0,95432 -0,72704 1,654173 -0,44132 0,780968 0,489108 0,792079 1,122914 3,400601 3,169251 3,788986 0,107624 0,267345 BRCA1_Pathway_E2_Responsive_Genes 0,247401 0,208864 0,260123 -0,15887 0,151453 -0,22293 0,519844 0,541202 0,408639 2,041761 1,873177 0,861841 -0,59103 -0,58651 -0,71497 -0,82759 -0,85609 -0,80214 0,108369 0,268198 glycolysis 0,139678 -0,03344 -0,09362 -0,29786 0,863588 -0,03574 -0,97083 -0,93769 -0,70136 -1,85435 0,585989 -0,23224 0,47837 -0,12827 0,245304 -0,13349 -0,84314 -0,34969 0,108578 0,268198 itrans_transi-farnesyl_diphosphate_biosynthesis 0,17613 0,059534 0,031715 0,043209 0,183318 0,686177 0,60332 0,738072 0,453787 -0,59308 0,41903 0,128205 -0,17867 -0,24414 -0,04154 -2,39943 -1,36276 -1,20471 0,108327 0,268198 KEGG_Insulin_secretion_Main_Pathway -1,05782 -0,38393 -0,05458 -1,0266 -2,15416 -2,42246 -0,80565 -0,8416 -0,002 -0,01831 -3,30148 -0,51893 -0,59816 0,214573 1,514219 9,036762 8,516124 9,716367 0,108145 0,268198 NCI_CD40_CD40L_signaling_Pathway_(B_cell_affi 0,037412 0,041113 -0,00937 0,066307 -0,51509 -0,17001 -0,36482 -0,24772 -0,62167 -0,82871 0,638019 -0,41223 0,35798 0,366944 0,142805 -0,91258 -0,73617 -1,14419 0,108564 0,268198 NCI_CD40_CD40L_signaling_Pathway_(plasma_ce 0,037412 0,041113 -0,00937 0,066307 -0,51509 -0,17001 -0,36482 -0,24772 -0,62167 -0,82871 0,638019 -0,41223 0,35798 0,366944 0,142805 -0,91258 -0,73617 -1,14419 0,108564 0,268198 NCI_Integrin_linked_kinase_signaling_Main_Pathw -0,07003 -0,28984 -0,50964 0,652101 0,514919 0,129117 -2,49892 -2,59459 -3,32422 -0,81205 2,94164 1,885252 0,304182 0,641618 0,549787 -8,68383 -7,01097 -5,0265 0,108432 0,268198 NCI_PDGFR_beta_signaling_Pathway_(chemotaxis -0,19371 -0,1207 -0,14996 0,398212 0,813177 0,25903 0,629692 0,504336 0,643193 -0,31756 -0,14736 -0,27623 -0,14232 -0,32487 0,334938 -0,0417 0,083145 0,21689 0,108938 0,268198 NCI_Signaling_events_mediated_by_Stem_cell_fa 0,059879 0,051511 0,047507 -0,18495 -0,31454 -0,22144 -0,19593 -0,1666 -0,48692 -0,41861 -0,31999 -0,32367 -0,11103 -0,12878 -0,06406 -1,57031 -2,11087 -1,34274 0,108817 0,268198 reactome_Endosomal_Sorting_Complex_Required 0,49666 -0,26898 -0,22753 -2,14194 -1,31848 -0,65753 1,410957 1,810517 0,544366 -1,95715 -1,56198 -1,47608 -0,51765 -0,78101 -0,01111 -9,78512 -7,75133 -6,03928 0,108899 0,268198 reactome_Heme_biosynthesis_Main_Pathway 0,230845 0,0554 0,080093 -0,02948 -0,18813 0,864204 0,081905 0,126698 -0,44593 -0,09663 0,292091 0,247944 0,314522 -0,05854 0,049005 -1,08214 -1,27605 -1,67616 0,108826 0,268198 reactome_The_retinoid_cycle_in_cones_daylight_ -0,1775 -0,05642 0,169225 -1,11789 0,147302 0,346893 0,399604 0,237814 0,310773 -0,6468 0,098402 -0,57038 -0,51109 -0,67346 -0,80531 0,404219 0,348243 1,157197 0,109001 0,268198 reactome_Deadenylation_of_mRNA_Main_Pathw 0,326402 0,080922 0,223645 -0,46368 -0,52148 -1,3737 -0,1905 0,455349 -1,2777 -1,66639 1,073325 -0,97714 0,599933 0,406795 0,75403 -7,97194 -5,07729 -3,84223 0,109352 0,268848 KEGG_Huntington_s_disease_Main_Pathway 0,178658 -0,12373 -0,00134 0,292588 0,727611 0,279343 -0,57732 -0,46341 -0,85501 -1,48322 -0,19698 -0,29124 0,672603 0,45897 0,704944 0,47911 0,869688 1,089785 0,109943 0,269877 reactome_Synthesis_of_glycosylphosphatidylinosi 0,8172 0,254103 0,348757 1,185794 -0,25515 0,6431 1,432728 2,230114 0,23037 -1,79302 -0,70967 0,097118 -0,96415 -0,48447 -0,59026 -5,00593 -3,54658 -3,13073 0,109858 0,269877 NCI_ATM_Pathway_(double_strand_break_repair 0,074457 -0,27221 -0,23547 -0,13169 0,807192 0,302525 0,097217 0,437251 -0,53752 0,114403 0,246825 0,310489 -0,23929 -0,17291 0,057144 -2,17965 -1,23722 -0,86144 0,110117 0,270091 reactome_Clearance_of_Nuclear_Envelope_Mem -0,01757 0,068574 0,060175 -0,55351 0,032572 0,510582 0,432615 0,60149 0,280914 -0,63574 0,407053 -1,16871 -0,0187 -0,42207 0,004538 -1,37051 -1,26071 -0,99508 0,110343 0,270432 NCI_CDC42_signaling_events_Pathway_(retrograd -0,00851 -0,11084 -0,08937 0,147012 -0,32376 -0,19682 -1,1487 -1,20201 -1,42503 -0,86638 0,255521 -0,21085 -0,3074 -0,47323 0,008304 -3,96934 -2,74443 -2,06175 0,110657 0,270988 KEGG_mTOR_signaling_Main_Pathway -0,85741 -0,05099 -0,27694 -1,63204 0,018864 0,589878 -0,23685 -0,70768 0,580809 1,884852 -2,00431 1,132028 -0,21595 0,14721 -0,32384 4,351048 3,195849 2,159035 0,111287 0,272315 reactome_Eukaryotic_Translation_Elongation_Ma -0,09928 -0,14731 -0,21658 0,402379 -0,44485 -0,06619 0,347943 0,332224 0,359062 -0,30694 -0,06817 -0,03876 0,066982 -0,40946 -0,25091 -1,24431 -1,68998 -0,9739 0,111615 0,272905 Chemotaxis_Driven_by_CCL2 0,057255 -0,40989 -0,48368 2,582332 0,790287 0,89399 -0,75055 -0,91204 -1,85115 -3,05694 2,152016 1,98331 -1,2629 -1,38916 -0,37902 -8,23737 -7,39929 -4,96747 0,111743 0,273003 Akt_Signaling_Pathway_Cell_Cycle_Progression -0,12111 -0,16922 0,277631 -1,44915 -0,17611 -1,24429 0,315424 0,333155 0,575767 0,34573 0,875976 -0,61658 0,57818 0,426384 0,212346 0,701023 1,468099 1,585697 0,111881 0,273127 reactome_NADE_modulates_death_signalling_Ma -0,04083 -0,04292 0,032505 0,156519 0,379991 0,237268 -0,28958 -0,33196 -0,33657 0,227829 0,357462 0,429376 0,190776 -0,01651 0,147984 -0,67944 -0,51077 -0,24798 0,112065 0,27336 thio-molybdenum_cofactor_biosynthesis -0,0477 0,06853 -0,03507 0,071495 -0,2722 -0,3159 -0,00484 0,009704 0,052787 0,000885 -0,09719 -0,04357 -0,21081 -0,33028 0,093872 -0,01879 0,313761 -0,14091 0,11243 0,274037 cAMP_Pathway_Endothelial_Cell_Regulation 0,525567 0,596894 0,515999 -1,60527 -0,78726 -1,50375 1,855336 2,398003 1,877904 2,222931 0,491943 -0,5457 -1,02468 -0,76696 -0,0879 -1,3311 -1,74714 -1,71904 0,112761 0,274393 NCI_FAS_CD95_signaling_Main_Pathway 0,146411 0,080064 -0,46822 -0,82128 1,239429 0,724277 -0,16467 0,17246 -0,82451 0,741658 1,192006 1,086217 0,738294 0,131301 0,682086 -5,53381 -4,57239 -2,51848 0,113017 0,274393 NCI_Stabilization_and_expansion_of_the_E_cadh -0,02616 -0,03828 -0,10053 0,392579 0,190342 -0,61003 -2,19119 -2,00928 -2,81753 -0,20382 1,093901 0,685242 0,071812 0,553299 0,560491 -5,88062 -3,31376 -3,19121 0,112996 0,274393 reactome_Regulation_of_AMPK_activity_via_LKB 0,096099 -0,27734 -0,24958 -0,88075 -0,31545 -2,13665 -0,21552 0,072656 -0,85899 -2,6292 -0,66004 -0,27733 0,071798 0,324698 0,113571 -4,22008 -3,42895 -2,797 0,11281 0,274393 superpathway_of_methionine_degradation 0,393317 0,508726 0,294896 -0,63046 -0,47606 -0,38757 0,123214 0,520363 -0,70319 -0,42529 -0,03176 -0,68164 -0,13221 -0,18583 0,83748 -6,24509 -5,94945 -5,34628 0,112856 0,274393 KEGG_Glycine_serine_and_threonine_metabolism 0,12377 0,227839 0,359259 -2,31651 -1,34794 -2,57976 1,075233 0,949843 1,28876 2,944032 1,133642 3,212064 -0,25823 0,105541 0,52722 -1,25117 -2,32206 -0,86379 0,11311 0,274406 cholesterol_biosynthesis_I 0,310437 0,187066 -0,00041 1,935505 1,364305 2,584686 1,248235 1,397201 0,837745 0,499059 1,052252 1,780455 -0,57348 -0,28607 -0,41056 -4,80282 -3,72672 -3,04301 0,1142 0,27619 cholesterol_biosynthesis_II_via_2425-dihydrolano 0,310437 0,187066 -0,00041 1,935505 1,364305 2,584686 1,248235 1,397201 0,837745 0,499059 1,052252 1,780455 -0,57348 -0,28607 -0,41056 -4,80282 -3,72672 -3,04301 0,1142 0,27619 cholesterol_biosynthesis_III_via_desmosterol 0,310437 0,187066 -0,00041 1,935505 1,364305 2,584686 1,248235 1,397201 0,837745 0,499059 1,052252 1,780455 -0,57348 -0,28607 -0,41056 -4,80282 -3,72672 -3,04301 0,1142 0,27619 purine_ribonucleosides_degradation_to_ribose-1 -0,05101 -0,03394 0,01092 -0,0756 -0,17983 -0,00701 0,806768 0,91589 0,81312 -0,63251 0,361007 -0,58698 0,102873 0,171613 -0,05583 -0,36754 -0,33112 -0,2388 0,113961 0,27619 NCI_Arf6_downstream_Main_Pathway 0,088835 -0,04851 -0,09971 -0,05261 -0,70381 -1,20365 -1,17636 -1,04775 -1,43454 -0,04004 -1,37396 -0,78737 0,456564 0,541104 0,27578 -2,03655 -1,57452 -1,10521 0,114767 0,277347 formaldehyde_oxidation 0,069792 0,083181 0,002666 -0,12425 -0,2661 -0,19452 -0,01037 0,113063 -0,11034 -0,72453 0,13163 -0,34735 -0,16457 0,112995 -0,10948 -1,45586 -1,41269 -0,92929 0,115986 0,280047 JAK-STAT_Pathway_Akt_Pathway -0,31477 -0,33318 -0,25585 0,333177 1,100297 0,904512 0,997875 1,548474 0,525771 1,174202 0,360131 1,239588 -0,4005 -0,05128 0,441787 -3,79412 -2,30988 -1,41309 0,116064 0,280047 biocarta_aspirin_blocks_signaling_pathway_involv 0,070837 -0,19015 -0,28395 -0,59125 -0,98899 -0,7432 0,312909 0,426265 0,103239 -1,04739 0,15366 0,4959 0,547037 0,568378 0,841151 -2,99221 -3,40919 -2,27442 0,116168 0,280079 HGF_Pathway_Anoikis -0,50074 -0,6078 -0,53911 -0,16562 -0,15723 0,497668 -0,95177 -0,16293 -2,01881 0,972039 0,149554 1,894638 0,230764 0,350141 0,982217 -4,95187 -2,80256 -2,12934 0,116869 0,281553 reactome_Signaling_by_SCF_KIT_Main_Pathway -0,09329 -0,23307 -0,12057 0,515215 0,341296 0,525075 -0,41108 -0,49603 -0,63451 0,695932 0,084117 1,121323 -0,56681 0,166184 0,215736 -3,27502 -3,601 -2,02331 0,116979 0,2816 KEGG_Salivary_secretion_Main_Pathway -0,09739 0,029977 -0,0004 -1,05503 -0,3658 0,927889 0,452486 0,152479 0,641039 -0,48109 0,045563 0,430738 -0,44284 -0,33589 -0,21301 1,711539 0,814935 0,534637 0,117196 0,281903 reactome_Membrane_binding_and_targetting_of 0,143573 -0,10348 -0,1751 -0,45932 -0,727 -0,06132 0,922501 1,126729 0,727593 -0,76248 -0,39394 -0,44833 -0,24593 -0,64181 0,148325 -3,81332 -3,13121 -2,10828 0,117694 0,282883 reactome_RNA_Polymerase_I_Chain_Elongation_ 0,89935 0,00951 -0,60647 0,900025 -0,50431 -2,76979 2,552614 4,025622 0,453458 -0,31191 -0,06672 -0,06599 -0,212 -0,71434 1,095894 -14,6896 -11,0269 -10,3373 0,11791 0,283183 NCI_Arf6_trafficking_events_Pathway_(membran -0,1288 -0,29338 -0,2453 0,327625 -0,75198 -0,75569 -0,24139 -0,24549 -0,52788 0,291112 -0,51512 -0,64025 0,729085 0,559732 0,210231 -0,9881 -0,95285 -0,79434 0,118176 0,283259 reactome_COPI_Mediated_Transport_Main_Path 0,159369 0,00531 -0,10622 -0,08704 -0,06301 0,101763 -0,23763 0,060274 -0,57064 -1,45055 0,665607 0,106178 -0,3168 -0,36306 -0,10591 -3,61783 -2,94791 -2,37897 0,118214 0,283259 reactome_Detoxification_of_Reactive_Oxygen_Sp 0,421474 -0,08145 -0,10407 1,206958 0,637354 -0,38431 0,622994 1,128773 0,317812 0,260767 0,855427 -0,34921 -0,29197 -1,36468 -0,10195 -8,61709 -7,15093 -6,09326 0,118065 0,283259 reactome_Voltage_gated_Potassium_channels_M -0,59476 -0,34069 0,433102 -1,25772 0,76492 -1,151 -1,57631 -2,16191 0,76235 0,045189 -1,18727 -1,02318 0,775702 -0,75811 1,286898 11,55982 9,425794 11,01081 0,119097 0,285156 KEGG_Viral_myocarditis_Main_Pathway 0,081168 0,052285 0,111775 0,053806 0,075667 0,635384 -0,78468 -0,53205 -0,94621 0,237476 -0,49175 -0,71523 -0,16833 -0,26739 -0,32147 -1,30273 -1,08876 -0,39913 0,119433 0,28574 NCI_Signaling_mediated_by_p38_alpha_and_p38_ 0,366373 -0,65662 -0,7379 -2,06866 -0,86202 -1,5082 -2,49006 -2,33617 -3,60102 -1,73779 0,294035 -1,40924 0,985234 0,174056 0,787132 -5,46466 -3,84181 -2,99829 0,119627 0,285984 ascorbate_recycling_cytosolic 0,034196 0,123611 -0,01659 -0,29795 -0,00437 0,197368 -1,3606 -1,3413 -1,60045 -0,24426 -0,0204 -0,35694 -0,15347 0,007951 0,032297 -0,37617 -0,64516 -0,52751 0,119942 0,286518 KEGG_Glutamatergic_synapse_Main_Pathway 0,23018 -0,11848 0,331255 -2,28066 -2,77278 -3,75289 -4,54743 -3,69922 -3,57719 0,570884 -2,26819 -0,89932 0,884708 1,68551 1,705576 5,019201 7,523414 5,200161 0,120059 0,286578 TCA_cycle 0,528699 0,233276 0,029171 -1,15307 -0,61 -1,26065 0,476874 0,940723 -0,38735 -2,90086 0,211998 -0,25568 -0,42475 -0,13968 -0,15707 -8,80234 -8,40734 -8,13764 0,120216 0,286733 methionine_degradation 0,055721 0,082329 0,013246 -0,1606 -0,15144 0,104954 0,128648 0,303429 0,110998 0,301727 -0,5496 -0,31041 -0,0278 -0,21579 -0,05198 -1,28909 -1,27055 -1,09904 0,120958 0,287931 NCI_Arf6_trafficking_events_Main_Pathway -0,19624 -0,14758 -0,31381 -0,46093 -1,34797 -1,10263 -4,28049 -4,27616 -5,62059 0,952674 -0,92919 0,609236 0,867075 0,930665 0,488606 -7,57712 -5,32189 -4,92986 0,120921 0,287931 reactome_Ca2_Main_Pathway -0,23537 -0,53892 -0,34213 2,374142 2,745094 0,630458 0,060878 -0,09222 0,410782 -4,48314 1,019559 0,485827 -0,0064 0,781871 -0,09095 0,330416 -0,06573 1,955325 0,120996 0,287931 NCI_BARD1_signaling_events_Pathway_(protein_ 0,082519 0,070634 0,022526 0,532548 -0,12551 0,868903 -0,69175 -0,55947 -1,08598 -0,42093 -0,08072 -0,16543 0,002734 -0,29013 -0,15505 -1,30745 -0,45894 -0,08832 0,121457 0,288807 reactome_Hyaluronan_uptake_and_degradation_ 0,07666 0,230991 0,187668 -0,10291 0,385739 -0,78033 -1,34307 -1,32469 -1,38447 0,720727 0,347316 0,640035 -0,1056 0,170375 0,1808 0,029999 0,332023 -0,01169 0,121688 0,289137 NCI_Class_I_PI3K_signaling_events_Pathway_(cel -0,02893 -0,14706 -0,24068 -0,54064 0,152903 0,492573 -0,71098 -0,7699 -0,99696 -0,39874 0,014044 -0,34991 -0,25156 0,472742 0,206554 -1,29644 -0,36756 0,273884 0,121979 0,289607 reactome_Gastrin_CREB_signalling_pathway_via_ -0,08813 -0,15182 -0,13235 -0,15104 -0,5853 -0,64803 -0,9058 -0,84063 -1,07629 -1,07147 0,25841 -0,13948 0,258497 0,325096 0,522874 -1,27857 -1,05527 -0,87648 0,122146 0,289782 125-dihydroxyvitamin_Dsub3sub_biosynthesis -0,09547 -0,09773 -0,10926 0,031495 0,045845 0,248999 -0,2256 -0,13243 -0,25032 0,761285 0,80995 0,719607 0,019868 -0,03713 -0,23619 -0,0934 0,111558 0,348655 0,12237 0,289873 NCI_IL5_mediated_signaling_events_Main_Pathw -0,10117 -0,32562 -0,09827 -0,52643 -0,00807 -0,40148 0,36864 0,51206 0,349198 0,889156 0,394104 0,47082 -0,54478 -0,45593 -0,12237 -1,0496 -0,10404 -0,08851 0,122347 0,289873 biocarta_yaci_and_bcma_stimulation_of_b_cell_i 0,262432 -0,24432 0,085543 -1,22687 -1,2722 -1,25555 -0,45475 -0,15605 -0,20493 0,889436 0,354453 0,332163 0,352278 0,180433 0,129622 0,047296 -0,17389 -0,51791 0,12315 0,291415 reactome_Signal_attenuation_Main_Pathway -0,08823 -0,23666 -0,24044 -0,14516 -0,39402 -1,21305 -1,77197 -1,97911 -2,02571 -0,2317 -0,89282 -1,07599 0,694625 0,426817 0,644912 -1,35538 -1,10729 -0,09904 0,123208 0,291415 KEGG_Nicotine_addiction_Main_Pathway -0,81359 0,395947 0,734079 0,012691 0,376724 -0,99628 -4,56861 -4,84069 -3,01025 2,957703 1,989793 0,59619 3,270261 2,228153 2,586664 13,21335 10,79824 10,63424 0,123624 0,292117 NCI_DNA_PK_pathway_in_nonhomologous_end_ 0,219849 0,099445 0,057695 0,329901 0,420543 0,107088 0,013763 0,189073 -0,27148 -0,11142 0,044698 -0,40729 -0,35895 -0,08135 -0,09005 -1,32544 -0,75896 -0,35411 0,123693 0,292117 biocarta_ahr_signal_transduction_Main_Pathway 0,013691 -0,00034 -0,06062 -0,02379 -0,22195 -0,00042 -0,65915 -0,58683 -0,75865 0,636127 -0,26659 -0,02507 0,366243 0,217258 -0,18784 -1,67397 -1,54293 -1,13164 0,124137 0,292361 biocarta_atm_signaling_Pathway_(DNA_repair) -0,03096 -0,1079 -0,10059 1,306572 0,987244 0,675584 0,381374 0,684051 0,220399 0,127446 1,003589 0,148094 -0,08444 -0,31752 -0,35304 -1,51471 -1,18469 -0,82443 0,12424 0,292361 biocarta_fmlp_induced_chemokine_gene_express -0,1125 -0,37594 -0,10317 0,020708 -0,58089 -0,86621 0,332476 0,924959 0,112331 0,181951 1,098096 -2,20444 -0,96891 -0,4253 0,390481 1,547325 1,503409 2,19189 0,124184 0,292361 reactome_CREB_phosphorylation_through_the_a -0,21474 -0,14105 -0,1094 -0,11382 0,198807 -0,53763 -0,71488 -0,54192 -0,74004 -0,27854 -0,77389 0,014024 0,007296 0,139951 0,490412 -0,48441 -0,19386 -0,04541 0,124265 0,292361 reactome_Metal_ion_SLC_transporters_Main_Pat -0,14308 0,008554 -0,23503 -0,83892 -0,02894 -0,51922 -1,03134 -1,0191 -1,40591 0,078231 0,491573 -0,17597 0,296528 0,428762 0,017563 -3,40588 -3,42766 -3,13188 0,124165 0,292361 NCI_RhoA_signaling_Pathway_(Golgi_organization 0,04093 0,054508 0,030899 -0,09262 -0,22224 -0,42841 0,119263 0,157536 0,128925 -0,42329 -0,11284 -0,6472 0,039402 -0,01882 -0,0036 -0,68792 -0,63941 -0,70232 0,124384 0,292421 KEGG_Aldosterone_regulated_sodium_reabsorpt -0,22149 -0,09499 -0,04071 -0,95811 0,092154 0,229951 -0,38133 -0,44544 -0,28106 2,06291 0,340122 0,956618 -0,5367 0,271783 0,146334 -0,0475 0,410047 0,173523 0,124853 0,293157 L-dopa_degradation -0,00067 -0,05655 -0,00989 -0,15492 0,029713 0,101154 -0,23246 -0,23768 -0,20226 -0,09219 -0,10213 -0,06483 0,093236 -0,03767 0,057107 -0,07356 -0,06518 -0,06625 0,125187 0,293157 NCI_ATM_Pathway_(chromatin_remodeling) -0,02024 -0,3092 -0,25652 -0,45934 0,434989 -0,04597 0,064268 0,340453 -0,48033 -0,53553 -0,05246 0,428531 -0,19512 -0,22805 -0,05696 -2,03104 -1,15251 -0,99712 0,125356 0,293157 reactome_Interleukin_receptor_SHC_signaling_M -0,14944 0,281279 0,162677 -0,77522 -0,29791 -0,92308 -0,27775 -0,74087 -0,08151 -0,24341 0,968738 0,867093 0,343105 0,013301 0,266777 -0,16157 0,288405 -0,08752 0,124924 0,293157 reactome_RMTs_methylate_histone_arginines_M 0,486639 -0,26317 -0,32691 1,328037 0,499312 0,801738 1,424208 2,218765 0,670263 0,737911 2,09005 -0,75165 -1,39167 -0,33999 0,607336 -7,39242 -6,08142 -3,71113 0,125266 0,293157 superpathway_of_pyrimidine_deoxyribonucleotid 0,371001 0,118886 0,021631 -0,57395 0,204654 -0,63914 2,224649 2,474799 1,174022 -0,18876 2,235129 1,163305 1,001629 1,317117 1,494807 -6,96306 -5,54717 -4,54204 0,125125 0,293157 TRAF_Pathway_Cell_Survival -0,33419 -0,23969 -0,22555 0,210482 0,223238 0,2774 0,487794 0,930759 0,355997 0,942085 0,232617 1,606212 0,240092 0,295419 0,654659 -2,75431 -1,98382 -1,66651 0,125289 0,293157 ATM_Pathway_DNA_repair 0,188782 -0,06959 -0,04805 0,276867 0,820053 0,199125 1,132032 1,420043 0,481532 -0,37412 -0,02431 -0,58174 -0,52143 -0,51544 -0,43341 -2,37902 -1,53515 -0,71637 0,126022 0,294446 NCI_ATR_signaling_Main_Pathway 0,924549 0,320463 0,24593 0,772432 0,709393 0,284222 2,423016 3,513193 1,180826 2,072261 -0,18159 0,125955 -0,48139 0,322683 0,726886 -9,25079 -6,03051 -4,56458 0,126097 0,294446 biocarta_keratinocyte_differentiation_Pathway_(a 0,13471 0,363479 0,183722 -0,96381 -0,005 0,642763 0,515076 0,428344 0,515055 -1,38011 -1,42321 -2,14682 0,48682 0,597034 0,336865 -0,02163 -0,35239 0,433856 0,12792 0,2945 biocarta_phospholipids_as_signalling_intermediar 0,013982 -0,17695 -0,08817 0,317843 -0,07728 -0,20011 0,274424 0,325287 0,02117 1,273386 0,081228 -1,37456 -0,47055 0,078117 -0,01074 -3,01122 -3,24032 -1,97116 0,127884 0,2945 biocarta_phospholipids_as_signalling_intermediar 0,013982 -0,17695 -0,08817 0,317843 -0,07728 -0,20011 0,274424 0,325287 0,02117 1,273386 0,081228 -1,37456 -0,47055 0,078117 -0,01074 -3,01122 -3,24032 -1,97116 0,127884 0,2945 biocarta_tgf_beta_signaling_Main_Pathway 0,110031 -0,174 -0,24828 -0,55408 -0,61981 0,149189 0,625516 0,848746 0,101696 -0,70966 -0,25871 -0,14869 -0,10992 0,306598 0,196426 -0,94376 -0,93253 -0,72637 0,126721 0,2945 biocarta_wnt_signaling_Main_Pathway 0,048075 0,077425 -0,05754 -0,20414 0,724997 -0,29855 -0,23441 -0,37471 -0,38837 1,494659 0,74411 0,689501 0,261863 0,184456 0,68962 1,276185 0,291002 1,444198 0,127708 0,2945 KEGG_One_carbon_pool_by_folate_Main_Pathwa 0,651546 0,055074 -0,06914 -1,37533 -0,19581 -1,11472 0,660471 1,310029 -0,09273 -0,84028 0,689652 -0,86574 0,389036 0,375725 0,667547 -7,07933 -5,72713 -4,42251 0,126936 0,2945 NCI_ATR_signaling_Pathway_(regulation_of_doub 0,805553 0,219997 0,176439 0,487031 0,844864 0,515997 2,143048 3,093501 0,866927 1,514054 0,574353 0,57241 -0,37285 0,281278 0,578944 -9,17206 -6,3334 -4,70003 0,128011 0,2945 NCI_Endogenous_TLR_signaling_Pathway_(cell_m -0,00639 -0,0484 -0,01952 -0,43459 -1,00886 -0,4377 -1,33618 -1,12629 -1,67764 1,587624 1,540782 1,11784 -0,46464 -0,67679 -0,71304 -1,36568 -1,20094 -1,17589 0,127197 0,2945 NCI_Endogenous_TLR_signaling_Pathway_(regula -0,00639 -0,0484 -0,01952 -0,43459 -1,00886 -0,4377 -1,33618 -1,12629 -1,67764 1,587624 1,540782 1,11784 -0,46464 -0,67679 -0,71304 -1,36568 -1,20094 -1,17589 0,127197 0,2945 NCI_LPA_receptor_mediated_events_Pathway_(a 0,104012 -0,0888 -0,20414 0,383017 -0,39321 -0,22407 -0,13997 -0,08944 -0,10891 -0,54121 -0,08803 -0,29164 -0,41457 -0,47099 -0,29296 -2,49344 -2,27321 -1,65216 0,127819 0,2945 NCI_LPA_receptor_mediated_events_Pathway_(M 0,104012 -0,0888 -0,20414 0,383017 -0,39321 -0,22407 -0,13997 -0,08944 -0,10891 -0,54121 -0,08803 -0,29164 -0,41457 -0,47099 -0,29296 -2,49344 -2,27321 -1,65216 0,127819 0,2945 NCI_LPA_receptor_mediated_events_Pathway_(p 0,104012 -0,0888 -0,20414 0,383017 -0,39321 -0,22407 -0,13997 -0,08944 -0,10891 -0,54121 -0,08803 -0,29164 -0,41457 -0,47099 -0,29296 -2,49344 -2,27321 -1,65216 0,127819 0,2945 NCI_Trk_receptor_signaling_mediated_by_PI3K_a -0,02783 -0,20912 -0,30407 -0,93804 0,220414 0,377445 -0,82242 -0,8289 -1,26032 0,082844 0,782453 0,019551 0,128475 0,119389 0,191797 -4,04676 -2,34954 -2,21456 0,126625 0,2945 NCI_Trk_receptor_signaling_mediated_by_PI3K_a -0,02783 -0,20912 -0,30407 -0,93804 0,220414 0,377445 -0,82242 -0,8289 -1,26032 0,082844 0,782453 0,019551 0,128475 0,119389 0,191797 -4,04676 -2,34954 -2,21456 0,126625 0,2945 reactome_Abacavir_transmembrane_transport_M 0,187761 0,335547 0,3157 0,340247 -0,02441 -0,53717 0,187584 -0,00557 0,393536 1,101228 1,142326 0,387475 0,995889 0,708399 0,467959 1,696571 2,020988 0,389214 0,127672 0,2945 reactome_Citric_acid_cycle_TCA_cycle__Main_Pa 0,540386 0,279722 0,104842 -0,81456 0,017545 -1,0525 0,902173 1,377356 0,085514 -2,69384 0,851345 0,242965 -0,38369 -0,22248 -0,20553 -8,99193 -8,39212 -8,1653 0,126509 0,2945 reactome_mitochondrial_fatty_acid_beta_oxidati 0,144487 0,123338 0,036592 -0,16567 -0,2668 0,097822 0,530057 0,614161 0,111303 0,212971 0,007869 0,0628 0,093719 0,148915 0,142911 -2,52258 -1,93743 -1,72851 0,127744 0,2945 reactome_Organic_cation_transport_Main_Pathw 0,256499 0,495084 0,023326 -0,42934 0,19621 -0,73601 -1,50973 -1,51576 -1,29466 0,565867 1,254893 0,021353 1,01329 0,566151 0,365685 1,836373 2,142756 0,351871 0,126377 0,2945 Regulation_of_Angiogenesis_by_Interleukin-8 -0,19761 -0,14291 -0,23228 -0,14247 0,140675 -0,07472 -1,67693 -1,68923 -2,0238 0,270078 -0,31224 -0,35087 0,051518 0,129017 -0,47967 -0,53012 -0,55169 -0,37563 0,127023 0,2945 VEGF_Pathway_Cell_Survival -0,3799 -0,25517 -0,26843 0,236688 0,665499 0,546393 0,560416 0,880811 0,249823 0,910492 0,189409 2,081477 0,100399 0,201926 0,625886 -3,43559 -2,1767 -1,65297 0,126773 0,2945 acyl_carrier_protein_metabolism 0,017651 0,014977 0,023092 0,262878 0,208982 0,192184 0,028452 -0,00188 -0,04021 0,040389 0,08282 0,071152 -0,04634 -0,11017 -0,11053 -0,38311 -0,3563 -0,36212 0,128363 0,295093 NCI_Glypican_1_network_Pathway_(BMP_signalin -0,19738 0,144514 -0,17398 -0,46524 -0,85281 -0,99581 -2,2505 -2,2944 -1,82314 1,765331 0,472363 -0,87823 -0,13835 0,462511 0,424741 0,369111 1,066802 0,352681 0,128833 0,295767 reactome_Beta_oxidation_of_lauroyl_CoA_to_de 0,098112 0,061908 0,049729 -0,21679 0,143379 0,090403 0,632574 0,639525 0,431672 0,698591 -0,14525 0,493722 0,290803 0,178269 0,1608 -2,52733 -1,99062 -2,22837 0,128846 0,295767 biocarta_fc_epsilon_receptor_i_signaling_in_mast 0,092194 0,35993 0,206648 -0,06269 0,609627 -0,85428 0,142758 -0,06686 0,304198 0,598417 -0,35356 -0,61156 -0,56309 -1,07104 -0,34642 0,195278 0,162593 0,129899 0,12914 0,296223 reactome_Activation_of_BID_and_translocation_t -0,1391 -0,09854 -0,02422 0,123757 0,589309 0,483436 -0,46021 -0,31589 -0,41412 -0,50188 0,322726 -0,10192 0,006988 -0,04242 -0,08276 -0,11381 -0,08513 0,245451 0,129304 0,29638 KEGG_Propanoate_metabolism_Main_Pathway 0,824094 0,214157 0,2559 0,336051 0,16226 0,035872 1,915456 2,653518 0,205602 0,264582 0,757515 1,969946 0,030289 0,476387 0,464465 -10,7133 -8,62261 -8,05908 0,129545 0,296715 NCI_ErbB_receptor_signaling_network_Main_Pat -0,04759 0,108379 0,345247 -2,40763 -2,16405 -3,73317 -1,016 -1,01573 -0,73115 1,539029 -0,00287 -0,83433 0,386749 0,600152 0,909202 0,908398 0,15881 1,352567 0,129886 0,297275 reactome_Collagen_biosynthesis_and_modifying_ -1,02837 -0,71572 0,011165 -3,25202 -2,81436 -3,836 -1,69267 -3,13683 1,082162 -2,04794 -2,56552 -1,78404 0,647223 -0,10197 0,471907 5,473129 5,351938 3,789626 0,12998 0,297275 biocarta_nf_kb_signaling_Pathway_(Pathway_pro 0,164825 -0,06238 0,197789 -0,34085 -1,37618 -2,53447 -3,70714 -3,37215 -3,70848 1,576769 0,310124 1,214454 -0,29221 -0,74241 -0,93734 -1,74495 -1,66545 -1,57414 0,130784 0,298499 FLT3_Signaling_Pathway_Translation -0,01277 -0,08401 -0,06703 0,282189 -1,00858 -0,5026 -0,98572 -0,89594 -1,26837 -2,17814 0,520855 0,232588 -0,31652 0,261323 0,327158 -2,24819 -2,40003 -2,14247 0,130803 0,298499 KEGG_Epstein_Barr_virus_infection_Main_Pathw -0,17291 -0,64764 -0,24728 -1,14872 -0,41141 -1,11438 -1,44171 -1,03291 -2,14353 -0,85502 -1,33248 0,380669 1,291914 0,123817 1,59036 -1,66456 -2,60488 -0,83343 0,130762 0,298499 Role_of_Rho_GTPases_in_of_Actin_Cytoskeleton_ -0,76241 -0,42703 -0,70258 -0,83986 -3,69039 -1,18367 -3,27101 -3,85898 -2,51275 -2,00075 -2,5155 -1,3891 0,479673 0,522532 0,351107 -4,44964 -4,35202 -2,19298 0,130972 0,298666 NCI_Syndecan_2_mediated_signaling_events_Ma 0,008443 -0,42454 -0,50401 -1,23963 -1,85309 -0,66031 -2,22361 -2,22427 -2,42425 2,308186 3,354398 0,782025 -1,21335 -0,82764 -0,65948 -1,40973 -2,09384 -2,01112 0,131504 0,299659 purine_deoxyribonucleosides_salvage -0,01864 -0,12318 -0,24417 0,022078 -0,3255 0,609814 -0,4747 -0,45925 -0,92133 0,959215 1,194474 0,905501 0,330971 0,251316 0,509815 -4,56644 -4,55162 -3,94733 0,131672 0,299823 Chemotaxis_Driven_by_CCR4 -0,13494 -0,51891 -0,5147 3,549574 3,159497 0,925819 -2,6446 -3,05482 -2,31243 0,534003 2,584948 1,978326 -0,15903 0,662867 0,282815 -1,49895 -1,92296 0,287423 0,131802 0,299899 NCI_Fanconi_anemia_Pathway_(regulation_of_do 0,888072 -0,04481 -0,07694 1,629733 2,743058 1,518419 4,565409 5,92467 2,462418 0,464079 1,999881 1,260344 -1,41652 -0,8048 -0,45326 -11,4217 -7,98599 -5,97301 0,13225 0,300701 pyrimidine_ribonucleosides_degradation -0,34098 -0,09045 0,007149 -0,08636 -0,01625 -0,82024 -1,2955 -1,45173 -1,01084 0,093604 -0,08277 -0,14017 -0,64997 -0,37297 -0,41679 0,243812 0,082961 -0,87307 0,132583 0,301236 Caspase_Cascade_Pathway_DNA_Fragmentation 0,122253 -0,04364 -0,08255 0,114606 -0,00846 -0,1615 -0,24879 -0,16134 -0,32109 0,225628 -0,43681 0,222641 0,241028 -0,1628 -0,18748 -1,48872 -1,24466 -0,92435 0,133086 0,301947 KEGG_Natural_killer_cell_mediated_cytotoxicity_ -0,87418 -0,25622 -0,67096 1,347636 4,966592 -0,19346 -4,91876 -5,07104 -3,94502 2,898447 3,132081 3,491117 -3,32635 -1,9157 -1,16779 2,482947 4,510036 6,223623 0,133089 0,301947 NCI_ErbB2_ErbB3_signaling_events_Pathway_(ac 0,07544 0,038417 -0,07116 -0,53321 0,190118 -0,12037 0,0058 0,138413 -0,26124 -0,02203 -0,12454 0,113286 0,06143 0,088513 0,16924 -1,95488 -1,23848 -1,02079 0,133286 0,302173 reactome_Regulation_of_cholesterol_biosynthesi 0,255457 -0,08977 -0,04199 -0,84761 -0,44491 -1,0545 -0,99454 -0,58862 -1,5565 -2,28389 -0,57899 -0,20312 -0,58016 -0,26516 0,005506 -5,40045 -3,70185 -2,9454 0,133821 0,303165 KEGG_Shigellosis_Main_Pathway -0,09585 -0,57896 -0,50914 -1,06401 -2,38889 -1,67965 -0,94865 -0,69815 -1,6827 -3,96258 0,13254 0,472274 0,393633 0,086542 0,894095 -6,34143 -5,32537 -4,3601 0,134194 0,303789 UDP-iNi-acetyl-D-glucosamine_biosynthesis_II 0,186023 0,066745 0,068919 0,160514 -0,14342 0,197511 -0,27312 -0,10685 -0,51377 0,430353 -0,21349 0,206238 -0,14 0,321979 -0,01901 -1,72441 -1,35968 -1,22288 0,135404 0,306307 NCI_Trk_receptor_signaling_mediated_by_PI3K_a -0,00963 0,015058 -0,01383 0,17246 0,06236 -0,12042 0,131449 0,125957 0,091831 0,107201 0,068105 -0,30615 0,002512 -0,1164 -0,01154 -0,48458 -0,28632 -0,30996 0,135575 0,30647 KEGG_Alcoholism_Main_Pathway -0,49681 -0,74164 -0,5861 2,791966 3,898143 1,564837 -1,54207 -1,45055 -1,61482 -3,58861 1,775075 -0,56609 -0,30869 -0,31845 0,571487 0,210536 1,030096 2,189659 0,136571 0,308274 NCI_Ceramide_signaling_Pathway_(negative_regu -0,01246 -0,36165 -0,2067 -0,92304 -0,62828 -1,17237 -0,95313 -1,04037 -0,94219 -0,88672 -0,46274 1,422666 -0,78225 0,03007 -0,68375 -0,64591 -0,52759 -0,5678 0,13654 0,308274 reactome_HS_GAG_biosynthesis_Main_Pathway -1,07165 -0,8425 -1,02479 0,218513 -2,11071 -1,68399 -0,64466 -0,84823 -0,72197 -1,47478 -1,21611 -2,07806 1,353672 -0,6483 0,324194 -0,34198 -2,08679 -2,53755 0,136798 0,308563 PRPP_biosynthesis 0,016436 -0,0859 0,043131 0,566318 0,3005 0,388946 0,449124 0,422823 0,372391 -0,71559 1,058764 0,262405 0,083888 0,091281 0,115635 -0,41943 -0,31545 -0,19753 0,137007 0,308811 reactome_Endogenous_sterols_Main_Pathway -0,56021 -0,24566 0,083171 1,164078 -0,47896 -0,35959 -2,23419 -3,04517 -1,72329 2,222236 -0,50156 0,100103 -0,04811 -1,06793 -0,06804 4,361724 0,894239 1,145887 0,137112 0,308823 NCI_CDC42_signaling_events_Pathway_(Pathway_ 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-1,71997 0,702297 -39,2505 -34,217 -30,1484 0,138548 0,310933 NCI_CXCR4_mediated_signaling_events_Pathway_ -0,04147 -0,12762 -0,22718 0,244049 -1,1247 -0,6847 0,184293 0,177979 -0,34992 -0,30369 -0,64746 -0,51158 -0,63989 0,159264 0,518823 -3,57493 -2,09127 -1,5269 0,138733 0,310976 reactome_Cleavage_of_the_damaged_purine_Ma -0,01997 0,067805 0,004594 0,548822 0,414784 -0,03601 -0,05762 -0,09353 0,074361 -0,68569 -0,22787 -0,42432 0,170342 -0,00422 -0,01639 0,316375 0,263772 0,185424 0,138866 0,310976 reactome_Recognition_and_association_of_DNA_ -0,01997 0,067805 0,004594 0,548822 0,414784 -0,03601 -0,05762 -0,09353 0,074361 -0,68569 -0,22787 -0,42432 0,170342 -0,00422 -0,01639 0,316375 0,263772 0,185424 0,138866 0,310976 heme_biosynthesis 0,074432 -0,10851 0,006638 -0,12671 -0,52696 -0,07247 -0,52965 -0,51411 -0,6031 -0,60826 -0,94658 -0,36905 -0,08627 -0,34855 0,015589 -0,29154 -0,70106 -1,01707 0,139066 0,3112 biocarta_spliceosomal_assembly_Main_Pathway 0,315095 -0,01332 0,1753 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0,314793 KEGG_Mineral_absorption_Main_Pathway 0,010189 -0,04326 0,037383 -0,12514 -0,2211 0,011829 -0,14467 -0,2724 -0,17747 -0,13733 0,11854 -0,39224 -0,10328 -0,2112 0,009012 0,05142 0,224413 0,27757 0,141741 0,315736 NCI_Signaling_events_mediated_by_VEGFR1_and 0,081689 -0,41785 -0,4092 -0,72578 0,791978 0,680141 -4,14558 -3,95249 -4,67689 1,909394 0,599519 0,494202 0,187465 0,213535 0,28501 -4,88835 -3,42506 -3,05951 0,141904 0,315736 NCI_TCR_signaling_in_naive_CD8_T_cells_Main_P -0,39346 0,515138 0,284516 -0,65161 0,186774 1,502173 2,513411 2,627111 3,643577 0,595748 -1,36517 2,391037 -1,41145 -1,67837 -0,63296 1,19418 0,344373 0,806958 0,141864 0,315736 Akt_Signaling_Pathway_NFAT_degradation -0,39812 -0,51711 0,020323 -0,36068 1,052592 -0,69715 -0,0718 0,120265 -0,22829 1,014173 0,24555 0,701444 0,534835 0,639236 0,615832 -3,11745 -1,528 -0,78786 0,142223 0,315925 Cell_Adhesion_Regulated_by_CDHs -0,31447 -0,09586 -0,61415 -1,08386 -2,66316 -1,92803 -3,93179 -3,86498 -4,15917 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NCI_Plasma_membrane_estrogen_receptor_signa -0,09875 -0,13949 -0,01532 0,368077 0,455984 0,295053 -0,37434 -0,48171 -0,39122 -0,04126 0,131578 0,030536 0,009602 -0,07086 -0,07855 -0,02268 0,028366 0,060989 0,143015 0,316625 KEGG_Non_alcoholic_fatty_liver_disease_NAFLD_ 0,149114 -0,06115 -0,26529 -1,37156 -0,97208 0,051986 -1,74436 -1,00745 -2,45958 -0,43729 -1,45981 0,230704 0,29879 0,139439 -0,07356 -5,50046 -3,51053 -2,163 0,14327 0,316964 IP3_Pathway_Gene_Expression_via_CREB3_NFAT 0,29874 -0,20321 -0,18141 1,216094 1,286294 1,476769 -1,89134 -1,52409 -2,54241 -3,20411 0,593273 -1,97438 -0,3932 -0,68897 0,323919 -0,79797 0,451237 1,378259 0,14351 0,317143 NCI_PLK1_signaling_events_Pathway_(chromosom0,036779 0,018355 -0,07069 -0,10383 -0,39212 -0,39398 0,604786 0,662168 0,476789 -0,72516 -0,90078 -0,40679 -0,13054 -0,00585 0,047866 -0,55743 -0,49418 -0,25832 0,143563 0,317143 reactome_Nitric_oxide_stimulates_guanylate_cyc -0,04133 -0,04184 0,009847 -0,78071 -0,59646 0,086226 0,149614 -0,07113 -0,03034 -0,59693 0,262733 -0,03892 -0,28303 -0,39578 -0,35617 0,044214 -0,47324 -0,43273 0,143758 0,317143 reactome_Role_of_Abl_in_Robo_Slit_signaling_M -0,03368 -0,05203 -0,06484 0,0072 -0,44926 -1,11642 -2,86749 -2,67679 -2,96313 -0,55313 -0,3693 -0,96301 -0,28862 0,232851 -0,02241 -2,08519 -1,38238 -1,28995 0,143664 0,317143 biocarta_role_of_mal_in_rho_mediated_activatio -0,04944 -0,3435 -0,43151 0,382267 0,542188 -0,95376 -0,54125 -0,2086 -0,90076 -1,12539 0,753774 -0,49969 -0,0372 -0,06129 -0,10497 -1,80287 -1,22836 -0,20858 0,144331 0,317163 Caspase_Cascade_Pathway_Activated_Tissue_Tra -0,89498 -0,38749 -0,47984 0,124169 -0,15541 -0,11521 -0,9698 -1,3937 0,755955 1,154434 2,032754 -3,42845 0,593322 -0,10141 -0,35597 8,664748 7,332935 6,670394 0,144122 0,317163 Cellular_Apoptosis_Pathway_DNA_Fragmentation -0,03682 -0,11868 -0,09972 0,006235 0,022657 -0,87219 -0,07196 -0,14632 0,020619 -0,38098 -0,54492 -0,33153 0,618094 0,114379 0,455046 -0,31206 -1,01413 -0,10322 0,143999 0,317163 Mitochondrial_Apoptosis_Pathway_Gene_Expres 0,192926 -0,06261 -0,02165 0,032822 -0,1639 0,001791 -0,0831 0,16123 -0,45618 -0,09241 0,521678 0,140762 0,133025 -0,00573 0,245153 -1,69006 -1,70072 -1,04067 0,144006 0,317163 NCI_ATF_2_transcription_factor_network_Main_ 0,035502 -0,31119 -0,2888 -0,40116 -0,24367 -1,21867 -0,99632 -0,47468 -1,71677 -0,30214 0,698021 -0,95716 0,353698 0,430572 0,624387 -2,92004 -1,78336 -1,24545 0,14448 0,317163 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(m -0,0916 -0,08439 -0,10295 -0,54144 -0,31195 -0,50374 -0,275 -0,09436 -0,31976 0,167679 -0,22369 -0,57068 0,471471 0,436378 0,357914 -1,093 -0,87445 -0,76789 0,144286 0,317163 sucrose_degradation -0,05387 0,088762 0,121302 0,620334 0,505024 -0,5572 0,774741 0,61986 0,686734 1,846927 -0,11038 1,07263 -0,06927 0,207611 -0,21938 0,854268 0,250113 0,611208 0,144415 0,317163 reactome_Switching_of_origins_to_a_post_replic 0,296229 0,20164 0,237263 0,648276 0,011318 0,174634 1,940386 2,017272 1,580751 -0,44004 -0,40896 -0,51328 -0,35739 -0,46524 -0,29208 -1,41901 -1,0948 -1,05241 0,144811 0,317667 biocarta_il_7_signal_transduction_Pathway_(cell_ 0,034459 0,121336 0,075791 0,077531 0,489551 0,226778 0,234072 0,262704 0,52531 0,226865 0,639571 0,275891 0,124998 0,210518 0,279884 1,322661 1,077123 0,70008 0,144923 0,317689 Hedgehog_Signaling_in_Mammals_no_Tubulin_P 0,355534 -0,23738 -0,34699 2,114371 1,200339 1,94575 1,430403 0,837943 1,149805 -0,63689 1,804118 1,665286 0,248958 -1,00102 -0,59041 -2,55259 -4,15685 -1,6329 0,145731 0,318562 NCI_TGF_beta_receptor_signaling_Main_Pathway -0,11531 -0,49219 -0,36124 0,868516 2,029188 0,934831 3,097241 2,959403 2,506279 0,532026 1,792517 1,594882 0,006399 -0,28425 0,448027 -1,26378 -1,56645 -1,62905 0,145604 0,318562 reactome_Dermatan_sulfate_biosynthesis_Main_ -0,33041 -0,15055 -0,21053 -0,7086 -0,11871 -0,06004 2,848428 2,872374 2,649186 -0,26975 -0,73089 0,371274 0,126224 0,145797 0,736618 4,199931 4,162572 3,799605 0,145706 0,318562 reactome_EGFR_downregulation_Main_Pathway 0,111444 -0,45621 -0,4634 -0,2459 -0,03675 -1,4832 0,510441 0,883936 -0,41376 -2,83073 1,013691 1,209774 -0,18284 -0,10292 0,223075 -6,60218 -4,47665 -3,68258 0,145561 0,318562 Regulation_of_Cytoskeleton_Remodeling_by_TGF -1,06768 -1,76509 -1,58414 -4,01738 -3,88075 -5,29327 -9,30437 -9,24146 -10,0003 -3,5596 -2,31634 -0,17558 2,390424 2,460403 1,944977 -12,8843 -7,55418 -7,3992 0,146091 0,319125 NCI_Signaling_events_mediated_by_Stem_cell_fa -0,00368 0,091422 0,069299 -0,54848 -0,46777 -0,19635 -0,48834 -0,60879 -0,5901 -0,48254 -0,47104 -0,53787 -0,11685 -0,11146 -0,10838 -1,33785 -1,79772 -1,29408 0,146348 0,319462 reactome_ATF6_alpha_activates_chaperones_Ma 0,054893 -0,017 -0,09661 0,063755 0,044316 -0,23671 -0,40605 -0,31837 -0,60914 -0,80195 0,316259 0,419482 0,076448 -0,07115 -0,064 -1,56695 -1,42015 -0,74674 0,146858 0,320352 NCI_CDC42_signaling_events_Pathway_(neuron_p -0,25169 -0,12658 -0,32012 -0,87858 -0,65155 -0,44634 -1,05166 -0,99867 -0,991 0,209473 0,132497 -0,44894 0,144253 0,197797 0,14156 0,653363 0,890963 0,492825 0,147085 0,320399 reactome_SUMO_is_proteolytically_processed_M 0,299911 0,038965 -0,02671 0,000996 -0,00312 0,154702 0,178986 0,373967 -0,19705 0,046553 0,518963 0,483542 -0,08437 0,404491 0,109955 -3,34427 -2,60949 -1,56243 0,14702 0,320399 reactome_SHC1_events_in_EGFR_signaling_Main 0,046494 -0,16185 -0,15067 -0,72028 -0,5169 -0,78473 -0,11746 -0,04257 -0,39341 -1,21365 0,18496 -0,86549 -0,08979 -0,15592 0,076124 -2,80521 -1,87327 -1,6875 0,147447 0,320963 reactome_Downregulation_of_TGF_beta_recepto 0,050498 -0,1909 -0,1804 -1,45874 -1,74796 -2,63592 -3,29273 -3,09879 -4,27554 -2,50583 -1,4937 -0,69883 0,608982 0,487663 0,798267 -6,56117 -5,07631 -2,8975 0,147596 0,321062 KEGG_Circadian_rhythm_Main_Pathway -0,00845 -0,01418 0,076072 -0,35576 -0,03448 0,606871 0,50373 0,332852 0,33342 -0,07032 -0,12646 -0,61689 0,096055 0,644216 -0,11787 -0,18016 -0,19471 -0,23059 0,147731 0,321133 reactome_Assembly_of_the_RAD51_ssDNA_nucle 0,004455 -0,05059 -0,06407 -0,1028 0,127673 0,433114 0,933821 1,094969 0,907534 1,210292 -1,09237 0,047025 0,21979 0,425826 0,352916 -0,46913 -0,17451 -0,29257 0,148162 0,321619 reactome_The_canonical_retinoid_cycle_in_rods_ -0,11342 0,116986 0,405731 -0,2035 0,761936 -0,07481 1,080878 0,784694 2,083664 0,983246 -1,33824 0,002597 0,408803 0,164642 0,026576 4,167015 3,856185 3,147061 0,148161 0,321619 ATM_Pathway_Cell_Cycle_Checkpoint_Control -0,00379 -0,0634 -0,09178 0,290489 0,594585 0,571485 -0,47887 -0,3661 -0,64127 0,131357 0,407165 0,276164 0,024778 -0,08526 -0,16186 -0,77457 -0,41875 -0,11444 0,148446 0,322012 Akt_Signaling_Pathway_NF-kB_pathway 0,129439 -0,20504 0,312429 -1,19451 0,156676 -1,124 0,215008 0,324593 0,277129 0,705922 1,060824 -0,89486 0,512493 0,271906 0,202842 0,419744 0,884193 1,17899 0,14865 0,322164 reactome_Cholesterol_biosynthesis_Main_Pathw 0,529328 0,345353 0,039604 1,919904 1,789472 2,776515 2,285289 2,709142 1,798853 0,5715 2,039572 1,880357 -0,57335 -0,42712 -0,66637 -6,68452 -4,40181 -3,86414 0,148723 0,322164 NCI_Aurora_A_signaling_Pathway_(regulation_of_ -0,00975 -0,02606 -0,12287 -0,19045 -0,28534 0,093971 0,762133 0,811736 0,666111 -1,19918 -1,05684 -0,90756 -0,31437 -0,19292 -0,05691 -0,27914 -0,04495 -0,20125 0,148836 0,322186 heparan_sulfate_biosynthesis_late_stages -0,70712 -0,40079 -0,73698 0,960139 -2,50701 -0,96428 -1,12315 -0,93945 -1,16447 -0,49683 -0,02097 -0,8496 0,998854 -0,03551 1,028468 -1,89178 -2,68969 -2,54161 0,14903 0,32238 Akt_Signaling_Pathway_Synaptic_Transmission -0,55572 -0,06447 0,483447 -2,85904 -3,35683 -3,49453 -2,21984 -2,41341 -1,9409 1,943826 1,593165 -0,76401 2,904837 2,321885 2,554701 6,009597 5,767568 5,270834 0,149408 0,322402 Rac1_Signaling 0,019946 -0,2513 -0,24702 -0,19512 -1,58671 -0,72052 -0,86102 -0,78222 -1,34649 -1,98111 -0,04846 0,407003 -0,32275 -0,29078 0,389716 -5,33273 -4,06538 -3,08475 0,149514 0,322402 reactome_Hyaluronan_biosynthesis_and_export_ -0,11616 -0,10748 -0,02174 -1,35651 -1,18131 -0,86075 -0,75389 -0,71984 -0,74447 -0,83279 -0,79526 -0,54618 0,191004 0,121435 0,334264 1,616582 1,616349 1,40086 0,149557 0,322402 reactome_The_fatty_acid_cycling_model_Main_P -0,11051 -0,01658 -0,00299 0,025619 -0,55758 -0,07717 -0,11461 -0,31492 0,227161 1,058376 0,329548 -0,01144 0,386892 -0,09767 -0,01242 0,252217 0,374685 0,019788 0,149526 0,322402 reactome_The_proton_buffering_model_Main_P -0,11051 -0,01658 -0,00299 0,025619 -0,55758 -0,07717 -0,11461 -0,31492 0,227161 1,058376 0,329548 -0,01144 0,386892 -0,09767 -0,01242 0,252217 0,374685 0,019788 0,149526 0,322402 NCI_Alternative_NF_kappaB_Main_Pathway -0,12288 -0,05543 0,04437 0,418586 0,155887 0,636835 -0,09228 -0,14307 -0,17068 0,222758 0,159527 -0,8147 0,355035 0,197487 0,262733 0,412496 0,347434 0,663023 0,149842 0,322569 NCI_Alternative_NF_kappaB_Pathway_(regulation -0,12288 -0,05543 0,04437 0,418586 0,155887 0,636835 -0,09228 -0,14307 -0,17068 0,222758 0,159527 -0,8147 0,355035 0,197487 0,262733 0,412496 0,347434 0,663023 0,149842 0,322569 NCI_Nephrin_Neph1_signaling_in_the_kidney_po 0,458411 0,49309 0,216338 -0,57603 -0,93911 -0,05892 0,810096 1,170675 -0,10041 0,038816 -0,68855 -0,40849 0,147609 0,081345 0,330648 -5,4495 -3,63946 -3,12946 0,150266 0,323035 reactome_Glutamate_Neurotransmitter_Release_ -0,14742 -0,28281 -0,17347 -1,09028 -1,4998 -2,29134 -2,88463 -2,92194 -3,0891 -2,48186 -2,44819 -2,22011 -0,20302 -0,57753 0,086098 6,107524 5,349251 5,97608 0,150259 0,323035 Akt_Signaling_Pathway_AR_mediated_apoptosis 0,056168 -0,12277 0,310806 -1,10351 0,444881 -1,42866 0,040691 0,017982 0,220743 0,771645 1,875064 0,051848 0,547804 0,476529 0,100758 -0,1277 0,805807 0,883112 0,1505 0,323092 KEGG_Arachidonic_acid_metabolism_Main_Pathw -0,78706 0,787769 0,579076 1,094406 -2,79145 -0,6145 -0,86249 -1,54949 2,059584 0,387391 -0,26697 3,694206 -0,17253 1,860385 0,645187 3,85643 2,633291 1,224304 0,150427 0,323092 NCI_ATR_signaling_Pathway_(response_to_G2_M 0,709282 0,148968 0,120988 0,672875 0,387428 -0,06191 1,65765 2,547863 0,583786 1,780286 0,308221 0,402776 -0,29181 0,039173 0,453755 -8,60419 -6,22105 -4,53891 0,15066 0,323214 biocarta_the_igf_1_receptor_and_longevity_Path -0,00489 -0,06334 -0,11899 -0,36451 0,455996 0,384107 -0,3084 -0,12304 -0,51028 0,078573 0,850435 0,290568 0,186148 -0,22213 -0,00506 -2,13205 -2,008 -1,71275 0,151893 0,324444 biocarta_the_igf_1_receptor_and_longevity_Path -0,00489 -0,06334 -0,11899 -0,36451 0,455996 0,384107 -0,3084 -0,12304 -0,51028 0,078573 0,850435 0,290568 0,186148 -0,22213 -0,00506 -2,13205 -2,008 -1,71275 0,151893 0,324444 ILK_Signaling_Pathway_Opsonization -0,06758 -0,05571 -0,09406 -0,77835 -0,91945 -0,86351 -0,65758 -0,56164 -0,72737 0,497909 0,161261 0,707711 -0,0447 0,0093 0,083864 -0,67885 -0,3606 -0,4547 0,151693 0,324444 NCI_Validated_transcriptional_targets_of_deltaNp 0,406492 -0,05135 0,195344 0,109558 0,356505 -0,01512 0,600152 0,581942 0,480907 0,567704 1,081655 -0,30519 0,345735 0,608482 0,757963 -1,10612 -0,97043 -0,21555 0,151963 0,324444 PTEN_Pathway_Synaptic_Transmission -1,00008 -0,44823 -0,55813 -0,76406 -1,27147 -0,04255 8,015228 7,702723 8,684655 -1,50624 -3,66755 -2,4318 -0,38152 -1,17833 -1,32512 11,26212 11,54496 9,133756 0,151397 0,324444 reactome_Budding_and_maturation_of_HIV_virio 0,307447 -0,25608 -0,11067 -2,05917 -1,41132 -0,70478 0,697037 1,006702 0,025721 -0,89523 -0,98763 -1,44906 -0,36691 -0,47866 0,229508 -7,83383 -6,12093 -4,35604 0,151933 0,324444 reactome_DARPP_32_events_Main_Pathway 0,097587 -0,24492 -0,08059 -0,67544 -0,08868 -0,14756 -1,10318 -0,72674 -1,48072 -2,56891 0,495614 -0,01605 -0,91604 -0,65589 -0,21319 -4,18088 -3,9672 -2,60104 0,151649 0,324444 biocarta_chaperones_modulate_interferon_signa 0,111691 0,020317 0,027588 -0,11721 -0,23345 0,471327 -0,02131 0,069219 -0,24508 0,039803 -0,01368 -0,4686 -0,08758 -0,18814 0,262776 -1,35739 -0,7449 -0,19819 0,15224 0,324751 biocarta_rac1_cell_motility_signaling_Pathway_(p -0,25628 -0,16256 0,059602 -0,38569 -0,54703 0,155884 -0,89107 -1,35829 -0,8137 0,74922 0,231863 1,383212 0,46888 0,52018 0,362747 2,080626 0,448235 0,620219 0,152419 0,324751 reactome_Dopamine_receptors_Main_Pathway -0,31785 -0,04161 -0,17632 -0,17171 -0,05392 -0,40262 0,077177 -0,0223 0,458108 0,0313 0,286523 0,207942 0,352231 0,358197 0,298464 1,490106 1,884529 1,458318 0,152401 0,324751 ATM_Pathway_S-phase_arrest 0,088571 -3,95E-05 0,001444 0,351852 0,438027 0,382865 -0,14104 0,040892 -0,32427 -0,19022 0,508823 -0,02814 -0,21381 -0,2028 -0,13334 -1,04542 -0,75117 -0,4211 0,153353 0,325619 NCI_Lissencephaly_gene_LIS1_in_neuronal_migra 0,082691 -0,08027 -0,05572 0,174861 0,037938 -0,05859 -0,21214 -0,0706 -0,42869 0,414243 0,139792 -0,08431 0,021936 -0,02135 0,075063 -0,82373 -0,96843 -0,48041 0,15307 0,325619 reactome_Dual_incision_reaction_in_GG_NER_M 0,657558 -0,14289 -0,28266 -0,58444 0,64598 0,822506 -0,88061 0,15764 -1,61029 0,889797 0,637579 2,161194 0,131785 0,359498 0,209765 -6,38574 -6,35246 -4,87191 0,153294 0,325619 reactome_Fanconi_Anemia_Main_Pathway 0,665582 0,098852 0,128853 0,307532 1,287157 0,115205 2,875042 3,302105 1,899227 -1,06336 0,631197 -0,54595 -0,86484 -0,65763 -0,64496 -4,84398 -3,52667 -2,32793 0,152976 0,325619 reactome_Formation_of_incision_complex_in_GG 0,657558 -0,14289 -0,28266 -0,58444 0,64598 0,822506 -0,88061 0,15764 -1,61029 0,889797 0,637579 2,161194 0,131785 0,359498 0,209765 -6,38574 -6,35246 -4,87191 0,153294 0,325619 reactome_Pyruvate_metabolism_Main_Pathway 0,342534 0,172329 0,10158 -0,35212 -0,04147 -1,44627 0,446356 0,636348 0,100028 -1,16281 -0,88519 -0,1541 -0,11066 -0,19296 -0,20745 -4,4091 -3,66738 -2,64501 0,153454 0,325619 Interferon_Pathway 1,399882 -0,81693 0,13091 -1,161 1,857382 -3,53923 3,079937 4,130779 1,104081 2,698673 4,179266 1,822897 3,573218 3,398159 7,075194 -10,1347 -7,17284 -6,3604 0,153718 0,325958 KEGG_Measles_Main_Pathway 0,271769 -0,27137 -0,07695 -0,93582 1,917692 -0,04925 -1,94991 -1,68296 -2,56119 -0,11768 0,249523 -0,09051 0,117421 -0,28667 0,184943 -1,65688 -3,17171 -1,14501 0,153925 0,326174 reactome_alpha_linolenic_acid_ALA_metabolism_ 0,188622 -0,00596 0,134163 -0,82351 -0,44339 -0,41623 0,237967 0,366331 -0,39465 1,94534 1,597774 1,635893 -1,09335 -0,9043 -0,78389 -2,63674 -1,34067 -0,91993 0,154575 0,326663 reactome_Beta_oxidation_of_decanoyl_CoA_to_o 0,131647 -0,00907 0,035917 0,099857 0,406845 -0,18356 0,803379 0,978253 0,544474 0,559042 0,117271 0,475032 -0,03358 0,00993 -0,17692 -3,15827 -2,69813 -2,55993 0,154554 0,326663 reactome_Beta_oxidation_of_octanoyl_CoA_to_h 0,131647 -0,00907 0,035917 0,099857 0,406845 -0,18356 0,803379 0,978253 0,544474 0,559042 0,117271 0,475032 -0,03358 0,00993 -0,17692 -3,15827 -2,69813 -2,55993 0,154554 0,326663 reactome_Vasopressin_like_receptors_Main_Path -0,19746 0,113484 0,140668 0,216346 0,458653 -0,23872 -0,01354 -0,1241 0,371233 0,42667 1,013849 -0,6416 -0,05655 0,156213 0,260746 1,329329 1,15052 1,804632 0,154268 0,326663 NCI_Integrin_linked_kinase_signaling_Pathway_(m 0,037003 0,052532 0,013897 0,033479 -0,13245 -0,13521 -0,546 -0,52091 -0,69081 -0,67646 0,074867 -0,13339 -0,14323 -0,12299 -0,06843 -0,89819 -0,51774 -0,62578 0,154684 0,326672 biocarta_the_igf_1_receptor_and_longevity_Main 0,050951 -0,20726 -0,25669 -0,22253 0,448963 0,003678 -1,49436 -1,15235 -1,95732 0,756158 0,677845 0,626855 0,348374 -0,14797 0,136905 -3,89755 -2,99698 -2,19764 0,155708 0,328612 NCI_PLK2_and_PLK4_events_Main_Pathway 0,129823 0,039757 -0,0146 -0,49326 -0,5027 -0,40061 -1,18231 -1,05615 -1,39043 -0,37297 -0,12136 -0,16771 0,443967 0,533188 0,593374 -1,28652 -1,0046 -0,79121 0,155935 0,328645 NCI_PLK2_and_PLK4_events_Pathway_(regulation 0,129823 0,039757 -0,0146 -0,49326 -0,5027 -0,40061 -1,18231 -1,05615 -1,39043 -0,37297 -0,12136 -0,16771 0,443967 0,533188 0,593374 -1,28652 -1,0046 -0,79121 0,155935 0,328645 KEGG_Valine_leucine_and_isoleucine_biosynthes -0,09654 -0,13291 -0,10688 -0,01825 -0,21018 -0,28229 -0,62349 -0,62748 -0,5737 0,502743 0,429437 -0,45313 -0,13378 0,143209 0,248009 0,756844 0,309411 0,588577 0,156178 0,328935 KEGG_NF_kappa_B_signaling_Main_Pathway -0,34733 -0,57599 -0,10751 -2,25526 -1,26063 -4,04186 -3,59931 -3,64238 -2,44648 2,97213 -1,70747 3,719406 0,569841 -0,71075 -0,07378 -0,70345 -1,43484 -0,82567 0,156725 0,329337 NCI_PDGFR_beta_signaling_Pathway_(cell_migrat -0,18008 -0,24091 -0,27585 -0,2922 0,345281 -0,04511 -0,15152 -0,11351 -0,15583 -0,27961 0,410977 -0,62642 0,07869 0,036029 0,156256 -0,25037 0,083066 0,016992 0,156687 0,329337 reactome_EGFR_interacts_with_phospholipase_C 0,026592 -0,03567 -0,01258 -0,07523 -0,18636 -0,57503 0,618961 0,704113 0,494984 -0,39201 -0,12463 -0,605 -0,01285 -0,23371 0,120132 -1,15974 -0,78552 -0,63993 0,156747 0,329337 reactome_Presynaptic_function_of_Kainate_rece -0,11945 -0,21758 -0,24285 2,242951 3,00216 1,282011 0,469486 0,314218 0,433272 -1,53262 1,607489 1,869544 -0,36409 -0,13237 0,139989 -0,8703 -1,04387 0,380107 0,156792 0,329337 CCR3_Pathway_in_Eosinophils 0,094802 -0,28699 -0,21204 3,030786 1,518059 0,212363 -0,5881 -0,88888 -0,64991 -3,08324 2,639875 0,450515 -1,95524 -0,91839 -0,67716 -6,02133 -4,91871 -2,96664 0,157655 0,330481 reactome_Antigen_Presentation_Folding_assemb 0,655531 0,091289 0,182448 -0,84284 -0,61509 -1,16285 -2,96939 -2,58032 -3,74574 0,724438 2,591261 0,541222 0,906507 1,058735 1,38407 -12,4768 -10,0661 -8,12116 0,157482 0,330481 reactome_Prostacyclin_signalling_through_prosta -0,07351 -0,04127 -0,19291 1,374168 1,118671 0,409589 0,038859 -0,24759 0,098077 -1,19414 0,927718 0,961665 -0,26209 -0,19195 -0,08462 -1,12857 -1,15757 0,034578 0,15764 0,330481 KEGG_Dopaminergic_synapse_Main_Pathway -0,62425 -0,5115 -0,43269 3,442745 4,792519 -0,46889 -1,80537 -1,44609 -2,16478 -1,30862 0,88628 0,604029 1,190393 0,178493 2,375039 0,859329 1,556295 3,146294 0,158055 0,330814 NCI_Fanconi_anemia_Pathway_(DNA_repair) 0,200464 0,100584 0,099074 0,710585 0,279246 0,946859 0,412411 0,536014 0,177327 -0,61402 0,272546 -0,00608 -0,32904 0,004971 -0,09919 -0,75974 -0,3287 0,028116 0,158132 0,330814 reactome_ADP_signalling_through_P2Y_purinoce 0,082898 -0,31152 -0,44452 1,068098 0,588688 -0,0499 0,431962 0,291717 0,084488 -2,34316 1,016147 0,707619 -0,99581 -0,65396 -0,65665 -3,65414 -3,07305 -1,85009 0,157925 0,330814 NCI_TCR_signaling_in_naive_CD8_T_cells_Pathwa 0,001925 0,146448 0,000952 -0,12829 -0,60939 -0,43996 0,604206 0,676042 0,935677 -0,44863 -0,16793 -0,4572 -0,2739 -0,37592 -0,12464 0,030096 -0,54068 0,082227 0,158469 0,331073 reactome_temp_Post-translational_modification_ -1,12339 0,479286 0,871222 -1,53124 1,844127 -0,54697 -1,10084 -2,46331 0,778865 -7,13281 -0,58499 0,387017 -1,39053 -1,86095 -0,93338 9,663837 9,550499 9,122257 0,158443 0,331073 NCI_ErbB4_signaling_events_Pathway_(neural_cr -0,11767 -0,00855 -0,02921 -1,27025 -1,03881 -1,62865 0,501106 0,470305 0,392731 0,207799 -0,19115 0,052516 0,300182 0,284276 0,221893 0,255269 0,116523 0,433981 0,159131 0,331346 NCI_Plasma_membrane_estrogen_receptor_signa -0,01239 -0,0052 -0,04381 -0,15188 -0,3626 -0,40512 -0,31745 -0,22607 -0,34263 0,206129 -0,09136 -0,50323 0,105027 0,208221 0,182002 -1,2407 -0,98032 -0,68028 0,158931 0,331346 NCI_Plasma_membrane_estrogen_receptor_signa -0,01239 -0,0052 -0,04381 -0,15188 -0,3626 -0,40512 -0,31745 -0,22607 -0,34263 0,206129 -0,09136 -0,50323 0,105027 0,208221 0,182002 -1,2407 -0,98032 -0,68028 0,158931 0,331346 NCI_Plasma_membrane_estrogen_receptor_signa -0,01239 -0,0052 -0,04381 -0,15188 -0,3626 -0,40512 -0,31745 -0,22607 -0,34263 0,206129 -0,09136 -0,50323 0,105027 0,208221 0,182002 -1,2407 -0,98032 -0,68028 0,158931 0,331346 reactome_Glucose_transport_Main_Pathway -0,27557 -0,09995 -0,08938 -1,40625 -1,21279 -2,05814 0,58719 0,239213 0,752112 -0,64414 1,028365 1,00925 0,28638 0,49072 0,60295 0,81906 0,077476 0,461975 0,159052 0,331346 NCI_Beta3_integrin_cell_surface_interactions_Ma -0,91928 -0,61711 -0,31033 -2,61758 -3,47383 -2,50679 -7,22132 -7,34164 -6,41432 1,835289 0,669981 -0,09571 1,309698 0,779703 1,490558 2,586611 2,451861 1,293079 0,159753 0,332197 pyrimidine_deoxyribonucleotides_ide_novoi_bios 0,244392 0,051762 -0,14844 -0,24719 -0,16296 0,042507 1,309423 1,439863 0,502155 0,42274 2,43464 0,948884 0,749806 1,021776 1,168331 -5,02397 -3,85845 -3,20303 0,15965 0,332197 RANK_Signaling_in_Osteoclasts_Pathway_Inhibitio -0,3922 -0,64317 -0,4185 -0,60447 -0,24715 -0,23546 -1,16563 -0,44343 -1,76202 0,087498 -0,21558 1,975437 0,001404 0,089384 0,591028 -4,4818 -3,64014 -2,40892 0,159986 0,332458 biocarta_how_does_salmonella_hijack_a_cell_Ma -0,00272 -0,20053 -0,24123 -0,32439 -1,23479 -0,12434 -0,95241 -0,69195 -1,37216 -0,93423 0,249324 -0,65377 -0,57276 -0,33192 -0,16228 -4,52913 -3,78485 -2,39207 0,160555 0,332532 biocarta_how_does_salmonella_hijack_a_cell_Pat -0,00272 -0,20053 -0,24123 -0,32439 -1,23479 -0,12434 -0,95241 -0,69195 -1,37216 -0,93423 0,249324 -0,65377 -0,57276 -0,33192 -0,16228 -4,52913 -3,78485 -2,39207 0,160555 0,332532 NCI_Plexin_D1_Signaling_Pathway_(focal_adhesio -0,07835 -0,11635 -0,11676 0,05598 0,068789 0,014747 -0,29946 -0,21934 -0,21079 -0,40716 -0,72154 -1,20419 0,236381 0,421889 0,35116 0,5332 0,571886 0,4056 0,16053 0,332532 NCI_Plexin_D1_Signaling_Pathway_(regulation_of -0,07835 -0,11635 -0,11676 0,05598 0,068789 0,014747 -0,29946 -0,21934 -0,21079 -0,40716 -0,72154 -1,20419 0,236381 0,421889 0,35116 0,5332 0,571886 0,4056 0,16053 0,332532 Neuronal_Development_Induced_by_CDK5 -0,44798 -0,86513 -0,51588 -2,63193 -4,74945 -1,51491 -7,08057 -6,8355 -8,48555 -4,20462 -0,62197 -0,70797 -0,88613 -1,22717 0,891193 -18,5105 -11,3957 -9,3298 0,160243 0,332532 reactome_Regulation_of_signaling_by_NODAL_M -0,04832 -0,03304 0,090679 -0,16333 -0,2609 -0,67662 0,572781 0,517676 0,989915 -0,65675 -0,35014 -0,22454 0,224988 -0,18023 0,233722 1,640795 1,478534 1,11692 0,160814 0,332848 cAMP_Pathway_Axonal_Growth 0,125226 0,142483 0,027402 0,142634 -0,68997 -0,95788 -1,57471 -1,38836 -1,80004 -1,63505 -1,16185 -0,76974 -0,27848 -0,09775 0,259463 -2,48759 -1,24677 -0,24751 0,161343 0,33316 KEGG_MicroRNAs_in_cancer_Main_Pathway 0,869106 2,180588 3,593383 5,254203 7,797126 5,650673 2,132258 2,438616 6,608363 5,757505 2,270461 0,559288 -3,44289 -4,6388 -3,96579 22,5722 12,84488 4,134161 0,16118 0,33316 KEGG_Primary_bile_acid_biosynthesis_Main_Path -0,10396 0,257604 0,323687 -2,7132 -0,39344 -1,20235 -0,80056 -1,32448 -0,55323 -0,60414 0,104785 -0,07917 0,155744 -0,41792 0,361993 0,468504 0,028579 0,147236 0,161393 0,33316 NCI_Regulation_of_Androgen_receptor_activity_P -0,10583 -0,06756 -0,25927 0,33731 -0,25722 0,629787 0,319989 0,484055 -0,41888 -0,96763 -0,48781 -0,36315 0,124843 0,279773 0,445197 -0,10693 0,793612 0,833871 0,16109 0,33316 NCI_BCR_signaling_Pathway_(re_entry_into_mito -0,22884 0,204784 0,129953 0,978243 0,582375 -0,22589 1,51937 1,056559 2,040875 0,347741 0,501151 0,666802 -0,36242 -0,71993 -0,2409 1,756466 0,132936 0,927441 0,162042 0,334111 reactome_Class_C_3_Metabotropic_glutamate_p 0,196906 0,272883 0,403441 1,263422 3,486272 2,940104 0,209434 0,034351 -0,14906 6,136125 5,207912 3,786545 -0,54288 -0,64044 -1,98481 1,744752 2,267469 2,218189 0,162068 0,334111 biocarta_alternative_complement_Main_Pathway 0,001293 0,394007 0,460791 -0,90293 -0,26769 1,219315 0,599241 0,44364 1,097891 -0,14092 -0,33513 0,257106 -1,02717 -1,06017 -1,10576 0,088156 0,140735 -0,06074 0,162241 0,334216 Mitochondrial_Apoptosis_Pathway_Depolarizatio 0,248481 0,067913 0,028493 0,056361 -0,19567 0,451576 0,053353 0,212551 -0,28941 -0,0181 0,746231 0,139151 0,117347 0,101125 0,210267 -1,51356 -1,64635 -0,91006 0,162334 0,334216 BRCA1_Pathway_Base_Excission_Repair -0,00676 -0,04436 -0,02535 0,666724 0,188953 -0,43947 0,598244 0,592696 0,374389 0,127465 0,297228 0,237836 0,287282 0,214277 0,32106 -0,47093 -0,41528 -0,20613 0,162454 0,334242 ErbB_Family_Pathway_Gene_Expression_via_JUN -0,21837 -0,58539 -0,47386 0,060553 -1,17159 -1,49568 -0,43804 0,294094 -0,87009 -1,40935 0,664955 -1,58055 0,464013 0,075448 0,717018 -2,44617 -1,71033 -0,74273 0,162597 0,334317 reactome_MHC_class_II_antigen_presentation_M 0,055517 0,049077 -0,3365 -4,33778 -1,82135 -2,2995 -8,34624 -6,91684 -9,8056 -3,50153 -0,81051 -1,16199 -0,04973 0,67121 1,999869 -12,9272 -9,97769 -4,69904 0,162705 0,334319 superpathway_of_purine_nucleotide_salvage 0,01197 -0,47962 -0,43059 -0,2795 -0,64331 -0,60657 1,540433 1,862742 0,824266 0,874401 2,822004 0,671376 0,455472 0,82418 1,405892 -7,26214 -6,18511 -5,15731 0,162959 0,334618 reactome_MyD88_independent_cascade_Main_P -0,1642 -0,11946 -0,22106 -1,14333 -0,93797 -0,9429 -1,95891 -1,77407 -2,2742 1,888752 1,72194 1,852325 -0,28499 -0,48175 -0,72147 -1,29104 -1,74826 -1,70366 0,163978 0,33649 reactome_G_beta_gamma_signalling_through_PL -0,0822 -0,18759 -0,22926 2,131446 2,717865 1,11607 0,234008 0,04351 0,22795 -1,4846 1,517539 1,524585 -0,41043 -0,26556 -0,09805 -1,07755 -1,2438 0,134536 0,164087 0,336492 KEGG_Hepatitis_C_Main_Pathway 0,631228 -0,54209 -0,372 -1,38088 -0,31713 -1,81202 -2,53577 -1,49012 -3,65375 1,282537 0,618628 -0,14476 0,920413 0,829052 1,172791 -7,41368 -6,37822 -5,18862 0,164836 0,337806 reactome_Generation_of_second_messenger_mo -0,95182 0,315516 0,3687 -0,25104 1,278358 2,168611 -1,4809 -2,29429 0,060998 0,323823 1,33503 1,875525 0,223645 0,488816 0,771702 5,712299 4,615831 5,790729 0,16508 0,338082 reactome_Gap_junction_degradation_Main_Path -0,0376 0,028143 0,006976 -0,10649 -0,30131 -0,49085 -2,38412 -2,2224 -2,43421 -1,34708 0,519158 -0,44722 0,031252 0,176603 0,301914 -1,09808 -0,96897 -0,40355 0,165544 0,33881 KEGG_Glycosaminoglycan_degradation_Main_Pat -0,04458 -0,06692 0,037903 -2,44636 -2,0551 -1,4506 -2,17473 -2,12306 -1,8588 2,183502 0,78578 1,530713 -0,4099 -0,87547 0,10243 -2,42769 -1,60666 -2,24018 0,165765 0,338817 resolvin_D_biosynthesis 0,00836 -0,0326 0,174881 -0,17837 -0,6135 -0,41461 -0,00912 -0,17897 0,077902 0,449813 0,557545 0,811472 0,337415 0,291403 0,316293 0,047224 0,457651 -0,13526 0,165754 0,338817 NCI_amb2_Integrin_signaling_Pathway_(actin_fila -0,00762 -0,12299 -0,1065 0,9763 0,18573 0,626987 -0,25308 -0,20816 0,035624 0,356671 -0,36524 -0,35395 -0,1239 -0,03945 0,028932 0,258262 -0,28726 0,343526 0,16628 0,339425 reactome_HDMs_demethylate_histones_Main_Pa 0,171944 -0,19199 -0,3031 -1,07221 -0,97931 0,295953 1,237076 1,691738 0,400988 -0,73648 0,988626 0,484886 0,690025 0,596564 1,115106 -2,84062 -1,95892 -2,30848 0,166233 0,339425 pyruvate_decarboxylation_to_acetyl_CoA 0,196874 0,10866 0,065896 -0,53973 -0,2181 -0,67413 0,214226 0,299547 0,072067 -0,91838 -0,34904 -0,63799 -0,17401 -0,0603 -0,12713 -2,35313 -1,79586 -1,24414 0,166683 0,340024 reactome_Chylomicron_mediated_lipid_transport -0,45577 -0,16511 0,049356 -1,03946 -0,27194 -1,18891 -2,28537 -2,846 -1,86257 1,076718 0,65952 -0,71128 0,388992 0,691103 0,299594 0,812994 1,301932 1,171637 0,167735 0,341946 biocarta_ras_independent_pathway_in_nk_cell_m 0,023785 -0,35788 0,251588 1,159194 1,953607 1,790386 1,340309 1,26867 1,449907 -0,029 -2,04322 -0,37234 1,543847 2,680774 1,168694 3,075375 2,809803 3,249453 0,168075 0,341969 HGF_Pathway_PKC_Pathway -0,25832 -0,24395 -0,04079 -1,02273 -1,1833 -1,52989 -1,21988 -1,08476 -0,97037 0,726371 0,571168 -0,23668 -0,12246 -0,28787 0,080397 -0,85506 -0,91265 -0,48259 0,168066 0,341969 reactome_Alpha_oxidation_of_phytanate_Main_ 0,020214 -0,09344 -0,02995 0,188288 0,347288 0,35251 -0,02675 0,113416 0,006424 -0,17084 0,46434 0,056896 0,005211 -0,46586 -0,37395 -1,14674 -1,29543 -1,13627 0,167859 0,341969 NCI_SHP2_signaling_Main_Pathway 0,271182 -0,39313 -0,23353 -0,83915 -1,02487 -1,84624 -4,64468 -4,92994 -4,87463 0,644327 -1,98467 -1,37915 0,678144 0,139261 1,230662 -4,53227 -2,60769 -1,70475 0,168362 0,342328 reactome_Sperm_Motility_And_Taxes_Main_Path 0,010695 0,223955 0,31924 0,408172 -0,01917 0,461161 -0,09612 -0,54728 0,232674 0,263482 0,102311 -0,00063 -0,34863 0,223745 -0,2077 1,307789 0,793382 0,328034 0,168542 0,342471 KEGG_Citrate_cycle_TCA_cycle__Main_Pathway 0,696985 0,290194 0,162902 -1,68683 -1,06898 -2,49595 1,374626 1,937477 0,379898 -2,50259 0,5988 -1,18707 -0,51788 -0,3468 -0,33422 -10,9005 -10,5961 -10,2568 0,16915 0,343483 biocarta_eukaryotic_protein_translation_Main_Pa 0,390631 0,365341 0,255419 -0,13188 0,190206 -0,77759 0,101276 0,354885 -0,58352 0,130416 0,144077 -0,27033 0,130771 -0,12928 0,106519 -6,02672 -4,16529 -2,68592 0,169357 0,34368 biocarta_erk_and_pi_3_kinase_are_necessary_fo 0,284574 0,217319 0,324852 0,198813 -0,1055 1,001191 2,001627 1,85539 2,002561 0,35348 -0,51359 0,191204 -1,55392 -1,0043 -1,45527 0,048281 0,19238 0,585693 0,169553 0,343853 GPCR_Pathway -1,62009 -3,35342 -2,04174 -7,99777 -0,4226 -5,10867 -15,2071 -13,9426 -16,1499 -6,29592 -5,33025 -7,6056 1,491534 2,390933 5,302866 -9,80593 -6,06014 3,311557 0,169915 0,344364 NCI_VEGFR3_signaling_in_lymphatic_endothelium 0,111923 -0,12538 -0,09954 -0,81257 0,27116 -0,39738 -0,82847 -0,91727 -1,15508 0,222146 0,574239 -0,0288 0,43191 0,247314 0,356926 -3,11543 -1,60463 -1,84071 0,17106 0,346233 reactome_Beta_catenin_phosphorylation_cascade 0,494021 0,030388 -0,057 0,391754 -0,17754 -0,4741 -0,64632 -0,35974 -1,16387 -0,29056 0,476032 0,43151 0,299219 0,28592 0,087531 -2,49528 -2,07853 -1,24322 0,171014 0,346233 reactome_PLC_gamma1_signalling_Main_Pathwa -0,04824 -0,0396 -0,00705 -0,02157 0,129351 0,150474 0,231508 0,056826 0,3492 0,119355 -0,07451 0,232931 0,209234 -0,05147 0,131756 -0,30197 0,005975 0,086485 0,171587 0,347073 biocarta_calcium_signaling_by_hbx_of_hepatitis_ -0,12306 -0,10054 -0,06178 0,356149 0,614943 0,554331 0,182853 0,137255 0,346122 -0,2361 0,437313 0,458475 -0,34877 -0,51809 -0,32747 1,628345 1,552248 1,137234 0,172212 0,348113 reactome_Oxygen_dependent_proline_hydroxyla 0,288294 -0,04847 0,010004 -0,83117 -0,47764 -1,36718 0,167158 0,263535 -0,50247 -0,23113 0,42011 -0,40128 -0,04395 0,110268 0,464754 -6,19401 -5,48921 -4,02316 0,17261 0,348689 dolichyl-diphosphooligosaccharide_biosynthesis 0,152394 0,064652 -0,00744 0,610214 0,119369 -0,11468 0,732322 1,030885 0,398584 0,365045 1,204101 0,363373 0,069807 -0,00644 -0,13277 -4,4987 -2,77692 -3,03153 0,17292 0,348864 Growth_Hormone_Signaling_Pathway -0,66585 -0,90013 -0,63042 0,048548 -2,75385 -2,86226 -0,79446 0,150153 -1,54402 1,270417 0,293293 -0,85304 1,618883 0,90872 2,058453 -7,53473 -6,29017 -3,58201 0,172846 0,348864 reactome_Rho_GTPase_cycle_Main_Pathway 0,294999 -1,0803 -0,53341 -0,72504 -2,03996 -2,66451 -7,11658 -6,77495 -8,803 -3,06292 0,681753 1,661567 -0,63427 -0,47751 0,834374 -14,6451 -10,4 -7,71992 0,173185 0,349172 biocarta_tsp_1_induced_apoptosis_in_microvascu -0,16774 -0,16173 -0,21471 -0,35306 -0,27305 -0,73205 -0,42304 -0,18302 -0,64309 -0,31704 -0,28398 -0,12656 9,81E-05 0,012209 0,192256 -1,78641 -0,55712 -1,1269 0,173869 0,349646 CMP-iNi-acetylneuraminate_biosynthesis_I_eukar 0,159743 0,025302 0,028706 -0,05048 0,230602 -0,00298 -0,23849 -0,14189 -0,50529 0,038796 0,195849 0,06999 -0,19346 0,165789 -0,389 -1,74588 -1,66858 -1,44386 0,173707 0,349646 NCI_ATR_signaling_Pathway_(Pathway_negative_ 0,700304 0,160149 0,138758 0,500554 0,679516 0,097946 1,603218 2,484906 0,557866 1,637974 0,859369 0,796537 -0,35461 -0,02747 0,361586 -8,34284 -6,08662 -4,49931 0,1736 0,349646 reactome_Conjugation_of_benzoate_with_glycine -0,10974 -0,00932 0,01505 -0,08622 0,212547 0,35317 1,005122 1,153121 1,023864 0,494837 0,081137 0,266849 0,507705 -0,02947 -0,22656 1,480098 1,387501 0,470504 0,173847 0,349646 superpathway_of_pyrimidine_ribonucleotides_ide 0,205792 0,151659 0,124606 -0,64241 0,050636 -0,58243 0,665096 0,822486 -0,03358 0,559563 1,581587 1,111234 0,851125 0,791473 1,086017 -5,41195 -4,67399 -3,93506 0,174247 0,35018 NCI_RAC1_signaling_Main_Pathway -0,19809 -0,18971 -0,34086 -3,22929 -1,62661 -2,39775 -1,46263 -1,18732 -2,57498 -2,58078 -0,17752 -0,05065 0,760353 0,736337 1,88483 -9,12493 -6,18037 -5,04431 0,174545 0,350553 NCI_Signaling_events_mediated_by_VEGFR1_and 0,091365 -0,33665 -0,33823 -0,70571 0,856641 0,719268 -3,72407 -3,54386 -4,45952 1,819786 0,797537 0,392401 -0,02894 0,069679 -0,01097 -5,06901 -3,58078 -3,03612 0,174757 0,350647 reactome_BH3_only_proteins_associate_with_an -0,19239 -0,20938 -0,13312 0,050082 0,698026 0,645819 -0,25065 -0,25112 -0,32067 -0,06013 0,286165 0,198733 0,02467 0,255302 -0,07941 0,012264 0,1042 0,334311 0,174817 0,350647 biocarta_regulation_of_map_kinase_pathways_th 0,292863 0,161525 0,067677 -0,31141 0,248148 -0,17272 0,615705 0,767194 0,252231 -0,418 0,11534 -1,17217 -0,06352 0,339083 0,064977 -0,81044 -0,27785 -0,27925 0,174946 0,350681 reactome_IKK_complex_recruitment_mediated_b 0,258584 -0,0159 0,096419 -0,31877 -0,52163 -0,16891 -0,17273 0,042939 -0,44632 0,354334 -0,28635 -0,13573 -0,02515 -0,19152 0,091312 -0,04892 -0,29264 -0,12806 0,175885 0,352335 NCI_FGF_signaling_Pathway_(MAPKKK_cascade) 0,050247 0,095663 0,12473 0,353596 0,179657 0,249079 0,247913 0,108535 0,374995 0,535757 0,528255 -0,24584 0,197499 0,11374 0,095601 1,201097 0,82519 0,74683 0,176601 0,353543 biocarta_ca_calmodulin_dependent_protein_kina -0,10099 -0,27544 -0,19585 0,260907 0,407879 0,468323 -0,21511 -0,1069 -0,44503 -0,91676 -0,06894 -1,75748 0,010576 -0,10676 0,064783 0,404512 0,493784 0,599903 0,176894 0,353771 KEGG_Starch_and_sucrose_metabolism_Main_Pa -0,26574 -0,27618 0,109463 -8,32631 -9,75999 -12,6919 3,339387 3,432275 4,162043 -4,50858 1,532553 2,60551 0,54968 -1,75368 -2,26245 -4,9864 -4,81373 -8,00085 0,176943 0,353771 NCI_Insulin_Pathway_Pathway_(negative_regulat 0,189969 -0,045 -0,04116 0,159672 0,042708 0,015406 -0,7678 -0,70733 -1,03954 0,664271 0,113385 -0,2164 -0,05077 0,00464 0,068935 -1,87126 -1,54367 -0,59245 0,177403 0,354465 Growth_Hormone_Signaling_Pathway_Gene_Exp -0,53319 -0,85515 -0,71429 -0,71095 -3,65328 -2,87775 -0,35214 0,801564 -1,11185 -0,16203 0,884742 -1,84616 1,307628 0,749968 1,8723 -8,65827 -7,26108 -4,61277 0,177814 0,35483 KEGG_SNARE_interactions_in_vesicular_transpor 0,11048 -0,01458 0,059862 0,227329 0,316941 -0,04783 -0,38606 -0,03304 -0,85035 0,511686 0,605006 0,858128 -0,12257 0,127758 0,206428 -2,6654 -2,6384 -2,42951 0,1777 0,35483 reactome_Toxicity_of_botulinum_toxin_type_E_B -0,14071 0,038156 0,017494 0,024632 -0,17559 -0,36155 -0,72321 -0,76195 -0,70437 -1,03875 -0,01499 -0,77566 -0,06343 0,080475 -0,19465 2,069472 2,503778 2,574462 0,178239 0,355451 NCI_ALK1_signaling_events_Main_Pathway -0,52633 -0,11057 -0,2789 -0,73186 -0,58306 -0,86841 -2,88993 -2,90573 -3,63996 -0,71951 -0,67529 -0,09556 -0,03167 -0,09591 -0,54002 -3,45556 -2,91975 -1,14591 0,179451 0,357182 TGF-Beta_Pathway_Transciption_Arrested_Growt 0,038693 -0,06578 0,117416 0,362661 -0,88281 -1,0886 -0,42544 -0,13482 -1,1856 -0,92663 1,016053 -0,72316 0,294018 -0,08572 0,116572 -3,77711 -3,05653 -2,19625 0,179401 0,357182 TGF-Beta_Pathway_Transciption_Cell_Growth_an 0,038693 -0,06578 0,117416 0,362661 -0,88281 -1,0886 -0,42544 -0,13482 -1,1856 -0,92663 1,016053 -0,72316 0,294018 -0,08572 0,116572 -3,77711 -3,05653 -2,19625 0,179401 0,357182 KEGG_Thyroid_hormone_synthesis_Main_Pathwa -0,05982 -0,00876 0,056499 -0,65592 -0,02409 0,164652 0,175351 0,003738 0,450756 0,634964 0,394687 -0,01077 0,38167 0,368886 0,387416 1,144997 0,74087 0,932967 0,179604 0,357257 KEGG_Oxidative_phosphorylation_Main_Pathway 1,623809 0,315101 0,421454 -4,32872 -6,79706 -4,4817 1,229243 2,181121 -2,25703 -6,11141 2,948322 -2,15605 -2,12007 -2,25113 -0,49742 -40,3101 -35,1806 -32,259 0,179802 0,357397 reactome_FCERI_mediated_MAPK_activation_Ma -0,00696 -0,05706 0,11957 -1,04492 -0,8198 -0,50292 -1,1476 -1,18159 -2,25361 -1,18487 0,298625 0,303384 0,476368 0,887619 0,873345 -3,08131 -2,24804 -1,26663 0,179903 0,357397 KEGG_Amphetamine_addiction_Main_Pathway 0,046845 -0,28976 -0,2281 1,62312 1,638678 2,503697 0,312303 0,454783 0,036745 -3,90763 -1,11311 -1,94463 -0,5436 -0,33354 0,090754 0,868886 1,884687 1,91725 0,180418 0,358066 NCI_HIV_1_Nef_Negative_effector_of_Fas_and_T 0,21032 0,092993 0,058915 -0,01313 0,00526 -0,09046 -1,4673 -1,05375 -1,66336 0,618922 -1,42344 -0,2461 0,005207 -0,40729 -0,61423 -2,69647 -1,96748 -1,56036 0,18047 0,358066 biocarta_signal_dependent_regulation_of_myoge 0,044532 0,043879 -0,04633 -0,06967 -0,13512 -0,29074 -1,55949 -1,61061 -1,60734 -1,26787 -0,1714 -0,30563 0,272903 0,108752 -0,17393 -0,26414 -0,72337 0,081596 0,180679 0,358167 FN1_Influence_on_Cell_Motility_via_Integrins -0,41448 -0,72891 -0,54852 -2,49804 -2,16598 -2,07018 -4,51196 -4,07198 -5,6014 -2,10146 -1,43994 0,285869 -0,11066 -0,06852 0,327362 -8,80948 -6,30941 -4,84766 0,181243 0,358167 NCI_DNA_PK_pathway_in_nonhomologous_end_ 0,176167 -0,01763 0,033455 0,614557 0,05151 -0,08061 -0,48631 -0,25981 -0,90648 -0,08888 0,6027 -0,35226 -0,56018 -0,06699 0,039327 -2,34222 -1,56683 -0,9355 0,18094 0,358167 NCI_mTOR_signaling_Main_Pathway 0,479429 -0,33544 -0,53452 -1,27633 -0,95899 -4,28191 -5,01922 -4,3398 -7,03693 -0,05235 -0,56594 -2,81188 0,724478 0,215324 1,039225 -9,79901 -7,31764 -4,38949 0,181257 0,358167 NCI_Posttranslational_regulation_of_adherens_ju -0,36735 -0,30929 -0,25392 -1,18197 -0,7685 -1,45516 -9,72631 -9,76895 -9,89368 -1,79049 0,778159 1,938006 1,247002 0,39763 0,758203 -5,18237 -3,65627 -4,92626 0,181326 0,358167 reactome_CS_DS_degradation_Main_Pathway -0,29719 -0,30679 -0,27223 -0,84859 -0,10313 0,107045 1,591393 1,689854 1,803249 0,924504 -0,64905 1,810431 0,79994 0,664632 1,634512 4,320026 4,142498 3,579828 0,181069 0,358167 reactome_Vitamin_C_ascorbate_metabolism_Ma -0,09735 -0,18259 -0,17252 -0,62668 0,285198 -0,13434 -0,95923 -0,91581 -1,15526 0,278943 0,27655 0,021518 0,635902 0,346923 0,280403 -0,56476 -0,49373 -0,70783 0,181032 0,358167 biocarta_pdgf_signaling_Main_Pathway -0,10503 -0,39286 -0,51007 -1,90237 -2,70321 -2,88509 -1,59045 -1,1148 -2,25435 -0,92008 0,33295 -0,15229 -0,20534 -0,61036 -0,06991 -2,8103 -0,469 0,376398 0,181463 0,358211 reactome_CD28_dependent_PI3K_Akt_signaling_ -0,32761 -0,26799 -0,29717 -1,36238 0,369283 0,387649 1,516755 1,689598 0,97283 0,163435 -0,82551 0,061011 0,111569 1,281665 0,885645 -2,10593 0,311936 0,031803 0,182307 0,359476 reactome_Regulation_of_innate_immune_respon -0,27695 -0,24246 -0,25272 -1,07832 -1,39307 -1,05576 -0,11433 -0,26803 -0,2529 1,316094 0,001177 -0,61665 -0,66706 -0,38189 -0,72172 -1,454 -1,39281 -0,98838 0,182334 0,359476 reactome_Glycoprotein_hormones_Main_Pathwa 0,091968 0,417454 0,294035 0,624566 0,610457 0,444637 0,209867 0,136177 0,409396 0,441397 0,75257 0,148262 -0,14166 0,174117 -0,69576 0,589546 1,024148 0,877476 0,182517 0,359608 Interferon_Pathway_Transciption -0,19911 -0,47688 -0,41527 -1,15067 -0,044 -1,13317 -0,16295 0,685312 -0,97382 0,087278 0,544627 1,200563 0,080543 0,497816 0,90704 -5,65986 -4,4845 -3,03989 0,183629 0,36157 biocarta_ucalpain_and_friends_in_cell_spread_M -0,21169 -0,22101 -0,41052 -0,91102 -0,64022 -1,16053 -2,18142 -1,94772 -2,30854 -0,86016 0,877803 -1,06119 0,455897 -0,00179 0,112183 -2,45694 -2,63549 -2,29449 0,183892 0,36163 reactome_negative_regulation_of_TCF_dependen 0,006472 0,0967 -0,02872 0,066693 -0,09384 0,043693 0,215442 0,183147 0,232515 0,157965 -0,02868 0,093469 0,305141 0,184845 0,322951 -0,38491 0,363502 -0,31218 0,183881 0,36163 Mitochondrial_Apoptosis_Pathway_DNA_Fragme -0,05888 -0,07435 -0,03647 0,205864 0,109458 -0,60851 0,373231 0,307083 0,427867 0,017042 0,064088 -0,24992 0,430502 0,090177 0,33517 -0,22101 -0,57713 -0,19103 0,184459 0,361684 NCI_amb2_Integrin_signaling_Main_Pathway -0,22797 -0,23617 0,039544 0,269461 0,238631 0,118025 -3,86649 -4,06117 -2,97256 0,551702 -1,23959 -0,94954 0,521448 0,953551 0,324228 1,061125 -0,24162 1,098632 0,184049 0,361684 NCI_DNA_PK_pathway_in_nonhomologous_end_ 0,287979 0,010487 0,051431 0,417057 0,114882 0,208787 -0,5292 -0,35093 -0,99974 -0,30212 0,559634 -0,18541 -0,51826 -0,07271 -0,03919 -2,18567 -1,32745 -0,7802 0,184616 0,361684 Neuronal_Intermediate_Filaments -0,00987 -0,13542 -0,0643 -0,13952 -1,08239 -0,42276 -0,81377 -0,9123 -0,9085 -2,10807 -0,45411 -0,35 -0,12455 -0,15314 0,133896 -1,21353 -0,97367 -0,99488 0,184564 0,361684 reactome_DNA_replication_initiation_Main_Pathw0,245434 0,229906 0,191441 0,317557 0,289854 0,810993 1,926168 2,111887 1,359596 -0,17918 -0,8091 -0,39413 -0,81704 -0,49663 -0,40978 -2,08324 -1,34839 -0,96125 0,184498 0,361684 reactome_Telomere_C_strand_synthesis_initiatio 0,245434 0,229906 0,191441 0,317557 0,289854 0,810993 1,926168 2,111887 1,359596 -0,17918 -0,8091 -0,39413 -0,81704 -0,49663 -0,40978 -2,08324 -1,34839 -0,96125 0,184498 0,361684 reactome_Relaxin_receptors_Main_Pathway 0,0524 0,126263 -0,07919 -0,02689 -0,01509 -0,46523 -0,17794 -0,30868 0,003767 0,933757 -0,21064 0,416348 -0,01535 -0,00313 -0,0817 -0,34127 0,026274 0,005394 0,185247 0,362693 KEGG_Glycosaminoglycan_biosynthesis_keratan_ -0,13816 -0,10167 -0,44372 1,506109 0,365225 2,393713 -1,82113 -1,94734 -2,03409 1,337092 1,09429 -0,75181 -0,5032 -0,44356 -0,09833 -1,75224 -1,67455 -0,33755 0,185395 0,362754 reactome_Branched_chain_amino_acid_catabolis 0,488952 0,138466 0,137054 0,178246 0,065539 -0,71632 1,276418 1,885677 0,138466 0,364449 1,897588 0,056131 -0,22288 0,39659 0,4518 -6,39571 -5,48034 -4,38655 0,186003 0,363715 glutaryl-CoA_degradation 0,030669 -0,0649 0,021266 -0,21872 0,338653 0,620294 0,23935 0,185854 0,292495 -0,14593 -0,29902 0,312764 -0,15621 -0,07198 -0,14439 -0,53182 -0,45257 -0,46214 0,186853 0,364568 NCI_N_cadherin_signaling_events_Pathway_(lame -0,0533 -0,06879 -0,09455 -0,01174 0,797557 0,039938 -0,36648 -0,38125 -0,66563 0,372111 0,964098 0,572058 -0,09131 -0,074 0,03194 -3,01565 -2,08434 -1,58466 0,186868 0,364568 PRL_Pathway -0,95026 -1,12238 -1,32865 1,434441 1,32365 -1,7917 -4,11607 -4,51532 -5,29244 2,358692 -0,80696 4,346858 -0,94182 0,395187 0,393284 -8,30897 -5,90395 -5,35672 0,187024 0,364568 reactome_Deposition_of_new_CENPA_containing 0,754548 0,064418 -0,13469 0,366748 0,279094 -0,73045 7,509824 8,431211 5,577711 0,367841 0,764367 -0,90715 -1,49334 -1,26946 -0,13568 -12,164 -7,31686 -6,52064 0,186574 0,364568 reactome_TRAF6_mediated_induction_of_TAK1_ 0,167036 -0,04342 -0,02383 -0,76867 -0,88744 -0,90272 0,223377 0,390346 -0,15073 -0,74596 0,085295 -0,36852 0,231007 0,264238 0,142693 -3,45967 -2,81412 -2,3666 0,18692 0,364568 biocarta_human_cytomegalovirus_and_map_kina 0,111309 -0,20158 -0,3353 -0,40195 0,219453 -0,47178 0,050975 0,350204 -0,65313 -0,38259 1,173664 1,251903 0,142583 0,403935 0,482727 -4,0641 -2,68035 -2,32474 0,187697 0,365013 NCI_Beta1_integrin_cell_surface_interactions_Ma -1,41367 -0,93467 -0,77072 -5,34221 -6,96752 -5,67914 -7,97496 -8,69363 -6,95346 1,379577 0,081013 0,328234 1,377796 0,40127 0,498502 1,159539 -0,61881 -1,49009 0,187412 0,365013 purine_nucleotides_ide_novoi_biosynthesis 0,124982 -0,2984 -0,43281 -0,21865 -0,24459 -0,70856 0,483439 0,742639 -0,33514 1,803319 2,264578 0,436146 0,209448 0,159697 0,997795 -7,73456 -7,14804 -5,76368 0,187721 0,365013 UTP_and_CTP_ide_novoi_biosynthesis 0,13738 0,1276 0,041779 -0,82461 -0,45347 -0,34865 0,626804 0,726954 -0,02938 0,828686 1,261693 0,698042 0,76359 0,87089 1,030895 -4,75766 -4,13349 -3,55018 0,187597 0,365013 KEGG_Pertussis_Main_Pathway 0,258582 -0,28892 -0,49935 -0,10865 0,058856 -1,50778 -2,83514 -2,22686 -3,74787 -0,02839 0,685871 0,836835 0,404526 -0,30197 -0,23505 -5,61445 -5,38014 -4,61367 0,188062 0,365301 reactome_Recycling_pathway_of_L1_Main_Pathw 0,337143 -0,01474 -0,16485 -0,13193 -0,5401 -0,95466 -2,92335 -2,63019 -4,0319 -1,55099 0,971912 -1,7421 -0,30275 -0,59733 0,148319 -3,54775 -2,81097 -1,81038 0,188104 0,365301 HIF1Alpha_Pathway_NOS_Pathway -0,28265 -0,38419 -0,30301 0,28471 0,859589 -0,53135 -1,2374 -1,10145 -1,20933 0,424346 -0,11615 0,939036 0,599478 -0,01083 -0,01326 -1,51815 -1,30264 0,217194 0,188391 0,365403 HIF1Alpha_Pathway_VEGF_Pathway -0,28265 -0,38419 -0,30301 0,28471 0,859589 -0,53135 -1,2374 -1,10145 -1,20933 0,424346 -0,11615 0,939036 0,599478 -0,01083 -0,01326 -1,51815 -1,30264 0,217194 0,188391 0,365403 Akt_Signaling_Pathway_Proto-Oncogenic_and_RT -0,02358 -0,16723 0,318774 -1,37508 0,471961 -1,12554 0,464341 0,37109 0,573745 0,699283 1,747049 0,023647 0,51417 0,381363 0,098533 -0,11582 0,423491 0,715391 0,188763 0,365897 KEGG_Adrenergic_signaling_in_cardiomyocytes_M -1,74591 -0,91782 -0,87076 -3,38281 -1,06368 -3,33949 -1,70054 -2,98638 0,199762 -2,8017 -1,32471 -4,6971 0,487278 1,918208 1,838128 16,00031 14,50736 16,49244 0,189141 0,366402 reactome_Terminal_pathway_of_complement_M 0,050998 0,222492 0,209417 -0,53156 0,127318 0,83479 0,608717 0,623153 0,913571 -0,31638 0,280605 0,352663 -1,07045 -0,97623 -1,00854 -0,32571 0,214936 -0,25787 0,189789 0,367428 NCI_Alpha_synuclein_signaling_Main_Pathway -0,07372 -0,25247 0,027448 0,065898 1,469789 0,412 -1,72216 -2,03116 -1,76718 -1,50818 -0,02281 0,495974 0,128915 0,629676 1,148887 1,636737 0,092625 0,840658 0,190532 0,36841 NCI_Aurora_C_signaling_Main_Pathway 0,091599 0,004394 -0,03599 0,236953 0,032259 0,120542 0,662355 0,729076 0,695623 -0,40587 -0,23056 -0,34104 -0,06435 -0,2139 -0,26217 -0,06706 -0,21661 -0,24767 0,190512 0,36841 NCI_Plasma_membrane_estrogen_receptor_signa -0,01829 -0,01741 -0,04178 0,33192 0,375471 0,169649 0,137812 0,145784 0,173793 -0,31012 -0,16591 -0,57054 -0,31568 -0,20432 -0,17642 -0,07514 -0,11768 -0,1722 0,190743 0,368588 pyrimidine_deoxyribonucleotides_biosynthesis_fr 0,203753 0,05255 -0,11665 -0,63838 -0,26465 -0,00246 0,854057 0,966974 0,034514 1,143982 2,552056 0,949979 1,023936 1,006767 1,407881 -5,60919 -4,39699 -3,64332 0,191063 0,368977 eumelanin_biosynthesis 0,190975 0,099297 0,299426 -0,45236 0,607414 0,158667 0,000884 -0,11101 -0,12245 0,794721 -0,14498 0,418208 -0,6105 -0,56573 -0,27376 0,020656 -0,08457 -0,39162 0,191571 0,369501 reactome_Degradation_of_cysteine_and_homocy 0,10275 0,125516 0,141399 -0,42951 -0,11705 -0,64293 0,510908 0,574118 0,29074 0,715885 0,310575 0,689497 -0,33583 -0,11914 -0,00175 -0,66763 -0,7974 -0,48595 0,191505 0,369501 cAMP_Pathway -6,93506 -3,4101 -1,693 -11,904 -6,04124 -13,6583 -25,2078 -28,676 -18,298 1,050086 -2,72317 -10,9501 3,970001 1,726879 7,07777 26,44164 21,41325 21,29186 0,191919 0,369943 NCI_Canonical_Wnt_signaling_Main_Pathway -0,25949 -0,46728 -0,41177 -0,59772 -1,04906 -0,96028 -1,44017 -1,33142 -1,89729 1,123296 -0,59912 -1,10013 0,378402 0,859856 0,488932 -2,10561 -2,38069 -1,10822 0,192166 0,370189 Akt_Signaling_Pathway_NO_production 0,095264 -0,13421 0,313246 -1,59692 0,392815 -1,09671 0,247582 0,103858 0,359702 0,103763 1,620288 -0,17909 0,633533 0,563268 0,13746 0,299677 0,995912 1,050663 0,19304 0,371645 cysteine_biosynthesis 0,050481 0,181394 0,073909 -0,21317 -0,0454 -0,00709 0,168315 0,256311 0,20778 0,425876 -0,45735 -0,12035 0,099355 -0,33385 0,101689 -1,27941 -1,47889 -1,05316 0,194135 0,373521 KEGG_Glycerolipid_metabolism_Main_Pathway -0,05041 0,274483 0,007327 -2,97124 -1,80394 -2,29191 1,0062 1,120842 0,413636 3,664245 0,995948 1,490645 0,38244 0,265401 1,48558 -1,90828 -0,84174 0,130037 0,194631 0,373783 reactome_Regulation_of_pyruvate_dehydrogenas 0,044397 -0,01168 0,002081 -2,35992 -1,67523 -2,18373 1,011125 1,019103 0,680015 -1,4146 -1,3071 -0,65002 1,256258 0,96101 1,211866 -5,26153 -4,37021 -3,50994 0,194424 0,373783 reactome_Trafficking_of_AMPA_receptors_Main_ -0,2332 -0,38454 -0,28063 0,865018 0,247424 1,23118 -0,85057 -0,67319 -1,11038 -0,10684 0,210183 -2,08418 0,183304 0,248778 0,424137 0,294605 0,749383 1,826935 0,194614 0,373783 reactome_Interleukin_7_signaling_Main_Pathway -0,25227 -0,08916 -0,0431 -1,97275 -0,96558 -0,90189 0,003535 0,177594 0,34941 0,94533 0,670925 1,045534 0,570422 -0,25 0,054955 -0,60998 -0,40666 -0,97025 0,194824 0,373923 KEGG_Sphingolipid_signaling_Main_Pathway -0,7248 -0,55866 -0,45036 -0,24734 1,182214 -3,87367 -0,69209 -0,87796 -0,43715 -0,96305 -0,59443 -1,43507 -2,20731 -0,45856 -0,37527 1,221619 2,424572 3,635679 0,195646 0,37527 HGF_Pathway_Cell_Cycle_Progression -0,18311 -0,2892 -0,36916 -0,39735 -0,9879 -0,23356 -1,19577 -0,92012 -1,69279 -0,23733 -0,16235 0,445731 0,049907 -0,13763 0,262803 -2,62651 -1,5802 -1,83434 0,196706 0,377069 reactome_Thrombin_signalling_through_proteina -0,33198 -0,64932 -0,62849 0,706996 1,381298 0,614857 -2,12977 -2,29519 -2,08875 -0,82123 1,921297 1,465644 -0,29911 -0,05393 0,323719 -1,50909 -0,95541 -0,0135 0,197203 0,377791 NCI_Nephrin_Neph1_signaling_in_the_kidney_po 0,073412 0,035436 -0,18013 -0,70006 -0,41027 -0,21739 -0,13421 0,051539 -0,60899 0,045296 -0,21976 -0,11814 -0,11306 0,13976 0,118169 -2,59275 -1,89134 -1,3573 0,19789 0,377945 PAK_Pathway -6,96767 -1,47325 -1,02202 -14,024 -5,85363 -11,1892 -17,8155 -22,4615 -9,7999 4,132367 -12,0989 -4,67579 2,365553 2,81153 3,562776 19,22551 12,01506 15,95865 0,197761 0,377945 PTEN_Pathway_Proliferation -0,8579 -0,13313 -0,15541 -2,44837 -2,72834 -0,34661 7,324681 7,124187 8,402838 -0,40221 -6,41443 -4,46454 1,182425 0,343514 0,052654 16,32861 15,59735 11,73493 0,197539 0,377945 PTEN_Pathway_Protein_Synthesis -0,01174 0,050407 0,010543 -0,14938 -0,00965 0,351828 -0,19434 -0,27513 -0,07322 0,001794 -0,40613 -0,14725 -0,21144 -0,25945 -0,4066 0,614412 0,349026 0,313177 0,19775 0,377945 reactome_Opioid_Signalling_Main_Pathway -0,15305 0,052551 0,014673 -0,02466 0,013286 -0,07885 0,04059 -0,10691 0,29912 -0,02739 -0,17722 0,028952 0,068015 -0,00552 -0,32207 0,774621 -0,09007 0,602515 0,197792 0,377945 cAMP_Pathway_Cell_Survival -0,15161 -0,35385 -0,13555 0,743676 0,740987 -1,5554 -2,67875 -2,63981 -2,64139 -4,52785 -1,65518 -0,51581 -1,06909 -0,71953 -0,12653 -1,94125 -1,76214 0,339634 0,198072 0,37806 NCI_Nectin_adhesion_Pathway_(positive_regulati 0,005047 -0,10937 -0,14759 -0,60353 -0,24823 -0,87317 -0,06142 0,031323 -0,15477 0,005021 -0,16318 -0,04853 -0,20392 -0,05393 -0,20759 -0,46227 -0,3579 -0,2548 0,199232 0,37984 superpathway_of_D-imyoi-inositol_145-trisphosp 0,250655 -0,2869 -0,05118 -0,14021 -0,51572 0,510358 -2,91048 -2,71219 -3,94485 0,174731 -0,29822 -0,676 -0,68382 -0,21482 -0,75429 -2,24413 -2,64835 -2,12088 0,199248 0,37984 biocarta_role_of_brca1_brca2_and_atr_in_cancer 0,242484 -0,08915 -0,07578 0,974986 0,716669 0,303764 0,296755 0,917842 -0,48118 1,088424 0,567701 -0,17857 -0,27179 -0,41921 -0,39149 -3,52964 -1,63032 -1,55024 0,200682 0,381645 KEGG_cGMP_PKG_signaling_Main_Pathway -1,10948 -0,44637 -0,47759 1,819094 5,487164 2,49477 -3,46516 -3,31558 -3,50037 0,430415 -1,84743 -0,7228 -0,17849 0,4859 2,231215 2,975662 1,965901 4,595463 0,200459 0,381645 NCI_BCR_signaling_Pathway_(cell_survival) -0,15349 0,073956 -0,00286 0,560982 0,215259 -0,16422 -0,06297 -0,37591 0,324963 0,38001 0,109172 0,314602 -0,27364 -0,62067 -0,32388 0,84939 -0,1002 0,121923 0,200685 0,381645 NCI_RhoA_signaling_Pathway_(actin_filament_de 0,080198 -0,01035 -0,001 0,333727 -0,0025 0,070655 0,164141 0,20106 -0,00672 -0,44277 -0,26498 -0,2828 -0,2825 -0,05767 -0,1657 -0,69242 -0,11872 0,079732 0,200509 0,381645 BRCA1_Pathway_NHEJ_DSB_Repair 0,135036 -0,03394 -0,09291 0,511902 0,754329 0,199871 0,079685 0,548235 -0,55155 0,539454 0,439468 0,507977 -0,32537 -0,13016 -0,27302 -2,56491 -1,33493 -1,46294 0,201481 0,381993 NCI_Ceramide_signaling_Pathway_(regulation_of_ -0,02648 -0,0752 -0,09834 -0,7799 0,04352 -0,42636 -1,24917 -1,13397 -1,48853 -0,46817 -1,1532 0,299415 0,242874 -0,20476 0,223231 -0,89612 -1,11955 -0,73036 0,201244 0,381993 NCI_Plexin_D1_Signaling_Pathway_(cell_adhesion -0,06977 -0,10958 -0,26199 0,288711 -1,02986 0,059534 -3,22305 -3,0866 -3,77634 0,796159 0,840167 0,254843 0,58279 0,574877 0,217013 -1,97909 -1,88647 -2,25614 0,201373 0,381993 reactome_Biosynthesis_of_the_N_glycan_precurs 0,179804 0,034333 -0,01077 0,444082 0,420503 0,40118 0,501232 1,048987 -0,36913 -0,84076 2,66747 0,052637 -0,61174 -0,63851 -0,28155 -5,53626 -4,13328 -4,34037 0,201035 0,381993 reactome_EGFR_Transactivation_by_Gastrin_Mai 0,067097 -0,12337 -0,10032 -0,74875 -1,05157 -0,75442 -0,37773 -0,21127 -0,47585 -0,95943 0,248568 -0,83755 0,069039 0,066304 0,144534 -2,3838 -2,3196 -2,0422 0,201245 0,381993 reactome_G_beta_gamma_signalling_through_PI -0,37457 -0,23783 -0,39484 2,383537 1,992169 1,467491 -0,1783 -0,61391 -0,24267 -0,52224 1,805564 1,492935 -0,70644 -0,41213 -0,31997 -1,99449 -1,45121 -0,20551 0,201645 0,382071 biocarta_tnfr1_signaling_Main_Pathway 0,173504 -0,05319 0,177817 -0,75222 -0,27606 -1,68097 -1,38543 -1,42148 -1,41608 -1,05624 0,337363 1,237407 -0,36673 0,074799 -0,40209 -0,80597 -0,35069 -0,63685 0,202089 0,38235 inosine-5-phosphate_biosynthesis 0,088596 -5,34E-05 -0,01488 -0,44723 -0,01598 -0,67938 -0,23747 -0,14095 -0,39169 -0,78429 -0,12449 -1,00705 -0,26185 -0,12912 -0,05033 -1,16449 -1,02083 -0,77448 0,202161 0,38235 WNT_Pathway_Cell_Fate_Proliferation_Differenti -1,93625 -1,60671 -1,58544 0,320447 1,535653 1,93813 0,674138 0,429741 2,37638 1,581679 0,849944 1,518692 0,617611 -0,46727 -0,07107 12,55383 7,863539 9,168931 0,202146 0,38235 NGF_Pathway_Apoptosis -0,03332 -0,1687 -0,11846 0,15896 0,337863 0,317918 -0,34962 -0,35049 -0,56382 0,758247 1,114342 0,363018 0,928319 0,481563 1,032157 0,504513 -0,18878 0,100538 0,202371 0,382515 PTEN_Pathway_Proliferation_CyclinA2_Geminin_A -0,24167 0,056037 0,07594 0,212859 -1,57776 -2,31862 -1,20972 -1,11136 -1,44191 -0,21808 -0,37892 1,430459 -0,87444 0,419628 1,033586 0,889099 1,181368 -0,18986 0,203154 0,38315 PTEN_Pathway_Senescence_Ets2_p16 -0,24167 0,056037 0,07594 0,212859 -1,57776 -2,31862 -1,20972 -1,11136 -1,44191 -0,21808 -0,37892 1,430459 -0,87444 0,419628 1,033586 0,889099 1,181368 -0,18986 0,203154 0,38315 reactome_Activated_NOTCH1_Transmits_Signal_t 0,304155 -0,04368 -0,18489 -1,8839 -0,08666 -0,72802 0,351691 0,665669 0,14837 -2,51207 0,822894 -0,14007 0,886838 0,907475 0,892594 -4,11424 -1,39204 -1,18257 0,203087 0,38315 reactome_Elevation_of_cytosolic_Ca2_levels_Mai -0,02305 -0,20464 -0,06831 -0,30712 0,5373 -0,18433 -0,29953 -0,36531 -0,32267 1,374694 0,137952 -0,32923 0,331544 -0,13782 0,079954 1,039237 1,056172 0,4997 0,203199 0,38315 reactome_Thromboxane_signalling_through_TP_ 0,010832 -0,20361 -0,29937 1,941017 2,254703 1,086915 -0,59056 -0,90205 -0,66069 -1,74732 1,090267 0,729334 -0,86628 -0,69281 -0,42551 -1,6735 -1,43348 0,251785 0,203355 0,383213 KEGG_Vasopressin_regulated_water_reabsorptio -0,28123 -0,30568 -0,3622 -0,47418 -0,48279 -1,37662 0,073997 0,264532 0,335745 -0,78533 -0,29536 0,766059 -0,62377 -0,47831 0,610823 -0,39542 0,351245 1,116034 0,203941 0,384084 ATM_Pathway_NF-kB_Pathway 0,061021 0,010379 -0,01444 0,481122 0,103658 0,183026 0,180701 0,268175 0,111708 -0,03189 0,405407 -0,20297 -0,25473 0,03879 -0,20848 -0,77259 -0,45954 -0,40245 0,205161 0,385421 KEGG_Insulin_signaling_Main_Pathway -0,75261 -0,63782 -1,03059 0,060914 -0,18229 -2,87613 -2,42101 -2,38307 -2,89829 0,011052 1,096915 1,515045 1,36669 0,224515 1,840209 -7,15875 -3,69895 -2,0489 0,205689 0,385421 KEGG_Pancreatic_cancer_Main_Pathway -0,15151 -0,17211 -0,45051 0,313019 0,68445 0,988986 -2,22741 -1,89786 -3,47728 1,203282 2,130344 3,212774 0,649492 0,71523 0,770538 -5,8674 -3,0564 -2,23044 0,205056 0,385421 NCI_LPA_receptor_mediated_events_Pathway_(c -0,07628 -0,01632 -0,10905 -0,36749 -0,48196 -0,49423 0,397337 0,381775 0,271305 -0,91257 0,29359 -0,08295 0,1838 -0,10292 0,000332 -1,86104 -1,31494 -1,10967 0,20479 0,385421 NCI_N_cadherin_signaling_events_Pathway_(axon -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 NCI_N_cadherin_signaling_events_Pathway_(card -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 NCI_N_cadherin_signaling_events_Pathway_(cort -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 NCI_N_cadherin_signaling_events_Pathway_(end -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 NCI_N_cadherin_signaling_events_Pathway_(long -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 NCI_N_cadherin_signaling_events_Pathway_(prot -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 NCI_N_cadherin_signaling_events_Pathway_(regu -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 NCI_N_cadherin_signaling_events_Pathway_(regu -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 NCI_N_cadherin_signaling_events_Pathway_(syna -0,06783 -0,08878 -0,03408 0,181768 0,818098 0,08342 -0,50174 -0,59219 -0,69332 0,421355 0,876944 0,364292 -0,14101 -0,14965 -0,08199 -2,12276 -1,52012 -1,20532 0,206506 0,385421 reactome_Meiotic_recombination_Main_Pathway 0,6918 0,023792 -0,03401 2,203436 -0,19794 -0,5167 8,326969 9,341505 6,470394 2,73511 1,988063 -0,98675 -0,64395 -0,57366 0,41459 -9,68589 -5,57517 -6,26386 0,206256 0,385421 reactome_Pentose_phosphate_pathway_hexose_ 0,148083 -0,12212 -0,07805 0,232029 -0,48423 -1,49431 -0,1077 -0,13732 -0,42764 -0,46287 -0,75385 -0,93807 0,121161 -0,1076 0,149948 -1,53415 -1,08036 -1,75622 0,205574 0,385421 bile_acid_biosynthesis_neutral_pathway -0,27433 -0,17483 0,03221 -2,34321 0,355515 -0,25436 -1,35056 -1,52267 -1,04384 1,329842 1,6515 0,822128 0,588987 -0,92395 0,189983 -0,01911 -0,62217 0,011246 0,20781 0,387621 NCI_Lissencephaly_gene_LIS1_in_neuronal_migra 0,320213 -0,25604 -0,09212 -0,19354 -1,04476 -0,15625 -2,16036 -1,86417 -2,78319 1,73068 -0,55183 -0,46392 0,038443 0,5726 0,79314 -3,0914 -2,54904 -1,81634 0,207947 0,387645 NCI_Alpha4_beta1_integrin_signaling_events_Pat -0,19773 -0,08093 -0,31581 -1,52423 -2,28949 -2,28864 -1,90588 -1,65035 -1,95418 1,993212 1,097385 0,657545 0,53916 0,437032 0,455597 -0,79712 -0,80086 -0,50218 0,208148 0,387788 IL-2_Pathway -2,14774 -0,72564 -1,65134 -3,13161 -0,3728 -2,87538 -6,27915 -5,90939 -7,22598 -0,21477 1,910815 4,565612 1,45694 1,236852 3,260545 -12,6522 -8,93689 -5,58884 0,208368 0,387966 reactome_Cytosolic_tRNA_aminoacylation_Main_ 0,779439 0,072595 0,207667 -1,70739 -1,31981 -1,26301 -2,24508 -1,83143 -3,58611 0,360573 1,11037 1,431594 0,292192 0,382041 0,378509 -14,2767 -11,1394 -9,49268 0,208626 0,388215 ILK_Signaling_Pathway_MMP2_MMP9_Gene_Exp -0,55335 -0,56003 -0,76067 -1,74348 -0,21904 -1,72518 -3,0223 -2,69591 -3,48747 -0,33 -0,49238 0,218372 0,547391 0,240798 0,147942 -3,40067 -3,24134 -2,28747 0,208903 0,388265 ILK_Signaling_Pathway_Tissue_Morphogenesis -0,55335 -0,56003 -0,76067 -1,74348 -0,21904 -1,72518 -3,0223 -2,69591 -3,48747 -0,33 -0,49238 0,218372 0,547391 0,240798 0,147942 -3,40067 -3,24134 -2,28747 0,208903 0,388265 cAMP_Pathway_Regulation_of_Cytoskeleton -0,07163 0,055702 0,064426 -0,29633 0,884969 0,906324 -1,13426 -1,07402 -1,00347 -0,54189 0,735642 0,272147 -0,46245 -0,1777 -0,11681 -1,84456 -0,85698 -0,99538 0,210439 0,389726 NCI_IL4_mediated_signaling_events_Pathway_(T_ -0,01555 -0,0012 -0,00137 -0,02657 0,026123 -0,04422 -0,12236 -0,16283 -0,01161 0,000622 0,173946 -0,01282 0,15705 -0,04839 0,060152 0,226058 0,198402 0,194562 0,2102 0,389726 NCI_IL4_mediated_signaling_events_Pathway_(T_ -0,01555 -0,0012 -0,00137 -0,02657 0,026123 -0,04422 -0,12236 -0,16283 -0,01161 0,000622 0,173946 -0,01282 0,15705 -0,04839 0,060152 0,226058 0,198402 0,194562 0,2102 0,389726 NCI_IL4_mediated_signaling_events_Pathway_(T_ -0,01555 -0,0012 -0,00137 -0,02657 0,026123 -0,04422 -0,12236 -0,16283 -0,01161 0,000622 0,173946 -0,01282 0,15705 -0,04839 0,060152 0,226058 0,198402 0,194562 0,2102 0,389726 NCI_Integrin_linked_kinase_signaling_Pathway_(D 0,049729 -0,00249 0,013205 0,656602 1,006292 0,260586 -2,02776 -2,18081 -2,33223 0,285557 2,114393 1,491658 0,221814 0,550022 0,104746 -2,45817 -2,38371 -1,57312 0,209967 0,389726 reactome_Signaling_by_NODAL_Main_Pathway -0,17631 0,288715 0,235011 0,267066 -0,20075 -0,07793 -1,77624 -1,87567 -1,66118 0,30377 -0,42789 -1,48306 0,212997 0,236333 0,371534 0,223442 -0,13157 -0,11448 0,210346 0,389726 reactome_VEGF_binds_to_VEGFR_leading_to_rec 0,046211 0,04796 0,025342 -0,2625 0,020972 0,268834 -0,51528 -0,61163 -0,41387 0,887624 0,032031 -0,31479 0,185137 0,100483 -0,01787 0,590222 0,604611 0,273655 0,210569 0,389734 reactome_HATs_acetylate_histones_Main_Pathw 0,653181 -0,36293 -0,79481 -1,72156 -1,37703 -3,8016 5,975545 7,571185 3,281165 -0,83389 2,983765 -1,09653 -0,53196 0,898418 1,598921 -14,8012 -10,8773 -8,36849 0,211008 0,390314 p38_Signaling_Pathway_Actin_Cytoskeleton_Reor -0,04767 -0,16118 -0,19803 -0,35015 -0,50395 0,035341 -0,16122 -0,09804 -0,23169 0,114391 0,336459 0,19861 0,280161 0,142957 0,428469 -1,43723 -0,82995 -0,8415 0,211206 0,390449 Chemotaxis_of_Immune_Cells_During_Allergic_A -0,25032 -0,491 -0,55967 3,356645 2,623927 0,176382 -2,72989 -3,07626 -2,30945 0,472498 2,503598 2,203195 0,011038 0,649144 0,356964 -1,31866 -1,04626 0,43999 0,211601 0,390947 biocarta_epo_signaling_Main_Pathway -0,2088 -0,16422 -0,07888 -1,0856 -0,35191 -0,56015 -0,04207 0,003823 0,064148 0,812388 0,304793 -0,02498 -0,47979 -0,96964 -0,54551 -1,82951 -0,72205 -0,7751 0,211752 0,390994 L-glutamine_tRNA_biosynthesis 0,152062 0,051148 0,046071 -0,21759 -0,18323 -0,41868 -0,07167 0,082755 -0,19198 -0,65719 -0,65951 -0,0744 -0,02683 -0,04551 0,067888 -0,72098 -0,46687 -0,54323 0,212601 0,392329 biocarta_rac1_cell_motility_signaling_Main_Pathw -0,282 -0,26496 -0,07314 -1,82911 -1,96837 -0,73593 -2,59364 -2,80127 -2,92011 0,065076 0,474354 1,628207 1,052281 1,416712 1,110879 2,071074 1,339319 2,404212 0,212876 0,392604 KEGG_Non_homologous_end_joining_Main_Path 0,449026 0,02836 0,211084 0,187311 0,274457 0,313797 -0,84654 -0,4847 -1,44598 -0,18594 0,489375 0,006617 -0,61776 -0,20316 0,193718 -2,44514 -1,83657 -1,03967 0,213337 0,393191 pyrimidine_deoxyribonucleotide_phosphorylation 0,017651 0,09022 -0,02959 -0,60489 -0,05005 -0,04782 0,26338 0,285942 -0,30003 1,133401 1,898846 0,624391 0,743978 0,801836 0,80084 -3,76696 -3,50896 -2,89237 0,213573 0,393191 reactome_Negative_regulation_of_FGFR_signalin -0,50057 -0,42472 -0,17657 -1,00721 0,292069 -0,37594 -0,75479 -1,09938 0,268608 -0,53627 -1,11921 -0,01438 -0,8272 -0,43224 -0,74514 -2,47809 -1,82544 -1,53631 0,213568 0,393191 NCI_IL8_and_CXCR2_mediated_signaling_events_ -0,05152 -0,11537 -0,15965 -0,3173 0,066418 -0,19784 -2,89672 -2,9654 -2,66484 -0,34949 0,29927 -1,01939 -0,21828 -0,41317 0,045941 -2,30657 -0,52697 -0,51408 0,21384 0,393451 biocarta_erk_and_pi_3_kinase_are_necessary_fo 0,332011 0,231039 0,390831 0,567814 -0,46342 1,133982 1,652869 1,542931 1,462657 -0,35414 0,104682 0,170069 -1,63077 -1,01847 -1,46591 -0,30623 0,315038 0,743018 0,214415 0,394258 NCI_Signaling_events_mediated_by_VEGFR1_and -0,02093 0,013017 -0,02333 0,0945 0,129041 -0,3016 0,137274 0,13941 0,102089 -0,14714 -0,35538 -0,4313 0,097816 0,009791 0,008174 0,044292 0,022822 -0,0702 0,214532 0,394258 estradiol_biosynthesis_I 0,187201 0,054171 0,126432 0,434679 0,257008 0,252426 0,058354 0,109339 -0,00122 0,168066 0,035891 0,505376 -0,12333 -0,03977 -0,32968 -0,84029 -1,29049 -1,33295 0,214943 0,394548 NCI_FGF_signaling_Pathway_(cell_migration) 0,069932 0,090218 0,090594 0,368847 -0,07678 0,438678 0,637585 0,598159 0,568474 -0,07382 -0,46638 -0,21858 0,029833 0,168065 0,142601 0,138847 0,248812 0,367131 0,214882 0,394548 reactome_Gap_junction_assembly_Main_Pathwa -0,47311 -0,11829 -0,46552 0,552271 1,20886 -0,79855 0,416355 -0,23204 1,965146 0,433211 0,610968 0,551624 0,270545 0,332742 0,038879 3,161193 2,443781 2,552191 0,215515 0,395364 Akt_Signaling_Pathway_Blood_cell_differentiation -0,01381 -0,11453 0,251415 -1,17442 0,507388 -1,56755 0,164284 0,033892 0,35442 0,560983 1,620332 0,462987 0,658744 0,623633 0,277838 0,147237 0,750449 0,730538 0,215999 0,395444 biocarta_influence_of_ras_and_rho_proteins_on_ 0,193454 -0,27161 -0,15541 -0,45963 0,098177 -0,24926 -0,96977 -0,55205 -1,48923 0,589248 0,836903 0,105519 0,065325 -0,18332 0,300328 -0,3843 -0,05524 0,638285 0,216999 0,395444 biocarta_lissencephaly_gene_lis1_in_neuronal_m 0,004719 0,012634 0,003382 -0,22169 -1,50251 0,22208 -1,03371 -1,01128 -1,47786 0,358162 -0,00648 0,168905 0,445678 0,840014 0,921599 -1,86185 -1,53512 -1,67952 0,216796 0,395444 ILK_Signaling_Pathway_Cell_Adhesion -0,0463 -0,04276 -0,07755 -0,36632 -0,56509 -0,48402 -0,844 -0,75718 -0,88829 0,455757 0,098799 0,775945 0,006892 0,063092 0,127964 -0,44086 -0,24238 -0,2411 0,216969 0,395444 ILK_Signaling_Pathway_Regulation_of_Junction_A -0,0463 -0,04276 -0,07755 -0,36632 -0,56509 -0,48402 -0,844 -0,75718 -0,88829 0,455757 0,098799 0,775945 0,006892 0,063092 0,127964 -0,44086 -0,24238 -0,2411 0,216969 0,395444 ILK_Signaling_Pathway_Wound_Healing -0,0463 -0,04276 -0,07755 -0,36632 -0,56509 -0,48402 -0,844 -0,75718 -0,88829 0,455757 0,098799 0,775945 0,006892 0,063092 0,127964 -0,44086 -0,24238 -0,2411 0,216969 0,395444 KEGG_Sphingolipid_metabolism_Main_Pathway -0,27534 -0,53848 -0,25836 0,022748 -0,0204 -1,49078 -5,47764 -4,9355 -5,61256 -1,62288 -1,36835 -0,06877 -0,83958 -0,83893 -0,65938 -2,75388 -3,10937 -0,8708 0,215774 0,395444 Mitochondrial_Apoptosis_Pathway_Apoptosis -0,03787 -0,03901 0,00699 -0,16931 -0,18527 -0,79039 -0,16092 -0,14945 -0,15324 0,164977 0,814943 -0,08952 0,711569 -0,26753 0,266953 -2,5912 -2,66372 -1,92911 0,216115 0,395444 NCI_Glypican_1_network_Pathway_(cell_growth) -0,20475 0,137654 -0,1976 -0,61144 -1,16519 -1,14229 -2,32124 -2,38528 -1,98771 1,45482 0,571825 -0,71916 0,043868 0,489345 0,644621 -0,02816 0,902599 0,141232 0,217412 0,395444 NCI_Glypican_1_network_Pathway_(fibroblast_gr -0,20475 0,137654 -0,1976 -0,61144 -1,16519 -1,14229 -2,32124 -2,38528 -1,98771 1,45482 0,571825 -0,71916 0,043868 0,489345 0,644621 -0,02816 0,902599 0,141232 0,217412 0,395444 NCI_Syndecan_4_mediated_signaling_events_Pat -0,05723 -0,26649 -0,0583 0,640766 0,38709 0,869915 -0,05059 0,04249 -0,21673 -0,28227 -0,11835 -1,18049 -0,68325 -0,52933 -0,03571 -0,62988 0,06911 -0,00913 0,217139 0,395444 reactome_Activated_point_mutants_of_FGFR2_M -0,54665 -0,24509 -0,14265 -0,70153 0,434572 -0,13915 0,372055 -0,03051 1,090906 0,990009 -1,35842 -0,41159 -0,92111 -0,94507 -0,77745 0,50599 0,334456 0,010869 0,217462 0,395444 reactome_Interleukin_1_signaling_Main_Pathway 0,514558 -0,22435 -0,10019 -0,68624 -1,18062 -1,81931 -2,14231 -1,84044 -3,50235 -1,0476 -2,05744 -1,74003 -0,27218 0,312706 -0,00313 -2,96446 -2,34238 -1,37125 0,216411 0,395444 reactome_Senescence_Associated_Secretory_Phe 0,439014 -0,41969 -0,80399 -1,33083 -4,05997 -4,91606 1,468819 2,190447 -0,28914 -3,67137 -1,64694 -0,68348 -0,37787 -0,08445 1,417913 -10,822 -8,95726 -7,7381 0,216341 0,395444 reactome_Synthesis_of_15_eicosatetraenoic_acid -0,00925 0,063926 -0,08162 -0,12464 -0,18094 0,122177 -0,28136 -0,25296 -0,13788 0,170033 0,005135 0,650204 -0,12739 -0,26512 0,046944 -0,08377 -0,06339 -0,23955 0,216705 0,395444 reactome_Molecules_associated_with_elastic_fib -1,00708 -0,34112 -0,64795 0,202478 -0,89761 -0,26463 1,042226 0,895543 1,162495 0,378027 -0,33127 -0,13743 -0,25345 -0,31236 0,066635 1,730042 1,375206 0,919977 0,217664 0,395579 beta-alanine_degradation -0,02157 0,006869 -0,0466 -0,16784 -0,08947 0,027934 0,514861 0,597244 0,380718 0,079937 0,113741 -0,00751 -0,07709 -0,10481 -0,03904 -0,13471 -0,2308 0,102924 0,218862 0,396028 biocarta_role_of_ppar_gamma_coactivators_in_o -0,09487 0,040076 -0,04891 -0,74475 -0,55923 -0,06483 -0,09334 -0,07535 -0,10433 -0,54032 -0,53884 -0,83756 0,242127 0,3985 0,272613 -0,89383 -0,26922 -0,19079 0,218928 0,396028 biocarta_role_of_ppar_gamma_coactivators_in_o -0,09487 0,040076 -0,04891 -0,74475 -0,55923 -0,06483 -0,09334 -0,07535 -0,10433 -0,54032 -0,53884 -0,83756 0,242127 0,3985 0,272613 -0,89383 -0,26922 -0,19079 0,218928 0,396028 KEGG_Inositol_phosphate_metabolism_Main_Pat -0,22796 -0,88978 -0,64133 -0,88377 -2,37327 -1,55478 -2,17386 -1,55031 -3,76939 -0,9073 -0,92041 -2,45577 -1,30816 -0,60053 0,464953 -4,8086 -3,66274 -2,45588 0,218294 0,396028 KEGG_Nitrogen_metabolism_Main_Pathway 0,05479 -0,0195 0,056921 -0,23187 -0,16622 -0,02145 0,705537 0,820604 0,679245 -0,2544 0,512791 0,015195 -0,10624 -0,04572 0,343137 -1,68033 -0,88748 -1,05143 0,218629 0,396028 KEGG_Ubiquinone_and_other_terpenoid_quinon 0,215318 0,119892 0,079585 0,118699 0,147117 -0,10342 0,517179 0,601254 0,187443 -0,11053 0,821878 -0,16963 -0,04043 0,149141 -0,19147 -1,37187 -1,16969 -1,9065 0,218079 0,396028 reactome_Retrograde_neurotrophin_signalling_M -0,01316 -0,12631 0,033038 -0,3449 -0,01661 -0,88751 -2,13927 -2,24414 -2,32236 -0,28997 0,885842 0,724022 0,483984 -0,00719 0,758326 0,261054 0,833114 1,171153 0,21867 0,396028 superpathway_of_cholesterol_biosynthesis 0,429918 0,287924 0,004873 2,191999 1,649916 3,429732 2,679151 2,687081 2,090887 0,663985 2,625731 3,291173 -0,92502 -0,74332 -0,87474 -7,9616 -5,09862 -4,4737 0,218717 0,396028 PLAU-mediated_Signaling_Events_During_Cell_Ad -0,38804 -0,6094 -0,73584 -1,77663 -1,38287 -0,81113 -0,21458 0,144845 -0,92136 0,527421 0,171315 1,526771 0,080383 0,316313 1,050344 -7,68056 -6,12184 -4,17308 0,219433 0,396711 biocarta_calcium_signaling_by_hbx_of_hepatitis_ -0,22292 -0,49329 -0,42234 -0,18485 -0,20481 -0,1225 -0,9453 -0,82144 -1,10838 -1,24083 0,521973 0,745528 -0,42115 -0,8089 -0,55385 -0,49705 0,839933 0,319135 0,220028 0,397507 reactome_Gluconeogenesis_Main_Pathway -0,09966 0,037884 0,025925 -1,44069 -1,2888 -2,37081 0,377005 0,485558 0,109686 -0,14741 -1,58554 -0,91837 -0,09465 -0,3431 0,500667 -5,28345 -5,59131 -4,72689 0,220128 0,397507 HGF_Pathway_Cell_Scattering -0,41976 -0,3654 -0,33744 -0,47917 0,109033 0,114473 -0,65748 -0,19308 -1,05788 1,473515 0,655982 1,745188 0,061585 0,267255 0,42893 -4,54013 -3,84727 -2,74891 0,220389 0,397517 HGF_Pathway_Cell_Survival -0,41976 -0,3654 -0,33744 -0,47917 0,109033 0,114473 -0,65748 -0,19308 -1,05788 1,473515 0,655982 1,745188 0,061585 0,267255 0,42893 -4,54013 -3,84727 -2,74891 0,220389 0,397517 ATM_Pathway_Apoptosis -0,11861 -0,06702 -0,13591 0,265807 0,184032 0,316706 0,295141 0,419961 0,216014 -0,00771 0,218205 0,058075 -0,10032 -0,1323 -0,15406 -0,3044 -0,1891 -0,08815 0,221445 0,399191 NCI_DNA_PK_pathway_in_nonhomologous_end_ 0,431139 0,01615 0,185841 0,430946 0,045662 0,338582 -0,81156 -0,53043 -1,3001 0,156549 0,093882 -0,46566 -0,62372 -0,23092 0,195345 -1,69299 -1,27712 -0,57387 0,221905 0,399788 reactome_Ion_transport_by_P_type_ATPases_Ma -0,36045 0,53048 -0,05649 1,412309 2,839254 2,273557 -0,90043 -1,09825 -0,83321 -1,19078 -1,37867 0,744467 1,811057 2,35074 1,875549 3,072945 3,998227 4,486265 0,222655 0,400907 cAMP_Pathway_Gene_Expression_via_NFKB2_CR -0,52488 -0,47868 -0,29999 -0,37977 0,14818 -0,52839 -2,32206 -2,00244 -2,69089 -3,03919 0,447667 1,586889 -0,38317 -0,25162 0,466238 -1,77012 -2,53562 -0,7039 0,223292 0,401823 NCI_Signaling_events_mediated_by_Stem_cell_fa 0,037936 0,042226 0,073119 -0,30404 -0,4594 -0,44638 -0,16076 -0,15301 -0,44546 -0,27195 -0,36323 -0,28137 -0,11214 -0,33649 -0,00205 -1,39289 -2,27577 -1,49438 0,223546 0,40197 NCI_VEGFR3_signaling_in_lymphatic_endothelium -0,05306 -0,04487 0,126791 -0,08998 -0,15703 0,255268 -0,60441 -0,73196 -0,59178 0,113799 0,309204 -0,01158 0,181921 0,017689 -0,06694 -0,89618 -0,45616 -0,56953 0,223632 0,40197 biocarta_role_of_pi3k_subunit_p85_in_regulation 0,044707 -0,13353 -0,12464 -0,10871 -1,04814 -0,17117 -0,73396 -0,59592 -1,04527 -0,77337 0,251595 -0,13703 -0,47902 -0,41087 -0,21309 -3,80432 -3,05932 -2,01422 0,223852 0,402133 biocarta_regulation_of_ck1_cdk5_by_type_1_glut -0,03599 0,016137 -0,15888 0,55621 0,684657 -0,60616 0,66731 0,482119 0,426966 1,801505 0,904481 0,682939 1,036158 0,734885 0,855673 2,305024 1,785639 2,354067 0,224222 0,402334 KEGG_Progesterone_mediated_oocyte_maturatio 0,207289 0,176727 -0,118 -1,17104 -1,6499 -2,2239 0,704497 0,94398 -0,11749 -1,27003 -2,43983 -2,305 -0,58485 -0,42297 0,531844 -4,54688 -3,50016 -2,37236 0,224141 0,402334 biocarta_rac1_cell_motility_signaling_Pathway_(a -0,03912 -0,13185 -0,0315 -0,41469 -0,09967 -0,339 -0,3646 -0,36929 -0,49503 -0,20222 -0,04952 0,100155 0,317771 0,387515 0,224084 0,804749 1,09247 1,367207 0,224856 0,40272 NCI_ATM_Pathway_(Pathway_rRNA_transcription -0,02089 -0,21978 -0,22112 -0,12921 0,534377 0,22079 0,197396 0,378463 -0,21592 -0,41746 0,126407 0,519164 -0,22517 -0,33538 -0,2442 -1,3342 -0,60964 -0,65652 0,225371 0,40272 NCI_RAC1_signaling_Pathway_(positive_regulatio -0,02459 0,049092 -0,06208 -0,19688 -0,01506 -0,11315 -0,25465 -0,2147 -0,34987 0,062513 0,124676 0,263786 0,240871 0,068834 0,177278 -0,95052 -0,75134 -0,24639 0,224577 0,40272 NCI_Stabilization_and_expansion_of_the_E_cadh 0,067669 0,071368 0,058191 0,318874 0,123146 -0,26453 -0,8281 -0,7148 -1,15109 0,348332 0,615035 0,603843 -0,40155 -0,01641 0,039008 -3,1949 -2,58637 -2,48919 0,225471 0,40272 NCI_Thromboxane_A2_receptor_signaling_Pathw -0,10794 0,036314 0,024808 0,004055 -0,13966 -0,40986 -0,2603 -0,40376 -0,13109 -1,09947 -0,00453 0,018561 -0,10131 -0,28095 -0,16394 -1,17795 -0,86434 -0,58013 0,22536 0,40272 NCI_Validated_transcriptional_targets_of_AP1_fa -0,13105 -0,1126 -0,20336 0,027838 -0,1225 -0,16197 -0,31502 -0,27412 -0,27757 -0,15383 -0,07631 0,568137 -0,0923 0,099812 0,168345 -0,54053 -0,5972 -0,31 0,22478 0,40272 reactome_Acyl_chain_remodelling_of_PI_Main_P -0,18152 0,094117 -0,04675 -0,86539 -1,38951 -1,64879 -0,34559 -0,52407 0,281835 -1,40399 -1,28101 -0,10117 -0,12777 -0,08834 -0,2062 0,225168 0,243421 0,01322 0,225285 0,40272 reactome_FGFR2c_ligand_binding_and_activation -0,39989 -0,19959 -0,03848 -0,64062 -0,11678 -0,63306 -0,63399 -0,99368 -0,04396 0,482779 -0,78948 -0,06711 -0,27919 -0,22615 -0,33524 -0,13997 0,223989 -0,60399 0,225453 0,40272 NCI_IGF1_Pathway_(positive_regulation_of_MAP 0,018142 -0,02623 -0,01184 0,034353 0,607254 0,475789 -0,34673 -0,50654 -0,512 0,702149 0,460685 0,090979 0,25219 0,137001 0,12761 -0,55665 -0,02535 0,107545 0,22563 0,402772 reactome_Toll_Like_Receptor_4_TLR4_Cascade_M -0,24595 -0,39292 -0,26266 -1,3776 -1,50928 -1,58577 -3,5526 -3,08007 -3,86341 0,358202 1,223992 0,363221 -0,30559 -0,77952 -0,38596 -2,00608 -1,54986 -1,53953 0,225952 0,403116 NCI_Regulation_of_nuclear_SMAD2_3_signaling_ -0,32516 -0,22917 -0,48813 -0,51459 -0,55674 0,643895 -3,11953 -3,29633 -3,51318 -0,27479 -0,89124 -0,36171 -0,26885 -0,20814 -0,1693 2,861983 2,037331 1,708256 0,226252 0,40319 p53_Signaling_Pathway -0,11286 -0,40838 -0,40022 0,62042 0,650679 -0,31996 -2,07881 -1,31102 -3,65835 1,585933 1,83225 2,85445 1,411988 1,115952 1,484721 -3,58321 -1,78949 -0,74508 0,226234 0,40319 NCI_Signaling_events_mediated_by_Stem_cell_fa -0,06613 -0,03236 0,001231 -0,61989 -0,35823 -0,66543 -0,64236 -0,71925 -0,80289 -0,341 -0,40677 -0,28299 -0,03449 -0,13196 0,077305 -1,19644 -2,09505 -1,34604 0,226394 0,403212 MAPK_Family_Pathway -3,10537 -2,72269 -1,45174 -10,618 -2,55003 -9,32422 -8,27252 -10,2363 -5,9018 4,557499 -3,3391 -1,49096 2,989393 1,329194 3,512085 3,81077 6,724565 10,49358 0,226889 0,403862 ITGA4-mediated_Cell_Adhesion_and_Migration 0,196593 -0,29697 -0,36419 -0,99032 -2,95629 -1,67513 -0,06442 0,160832 -0,88209 -2,95371 -0,14849 0,112262 -0,29776 -0,34205 -0,14388 -7,66743 -5,8622 -5,56208 0,227731 0,404943 reactome_Nuclear_signaling_by_ERBB4_Main_Pa 0,055036 -0,2171 -0,12308 -0,37445 0,491195 -0,069 0,04834 0,138133 -0,26594 0,281405 0,755232 1,027765 0,272302 0,55812 0,650712 -1,76534 -0,56766 -0,89596 0,227756 0,404943 NCI_ErbB4_signaling_events_Pathway_(epithelial_ -0,24426 0,003101 -0,03331 -2,04215 -1,78273 -1,23865 -0,66146 -0,84454 -0,84262 -0,24135 -0,38884 0,074774 0,017704 -0,084 0,141781 -0,81176 -0,57532 -0,27341 0,228085 0,405065 NCI_Fc_epsilon_receptor_I_signaling_in_mast_ce 0,000604 0,075929 0,379844 -0,03375 -1,66013 2,045649 -0,37795 -0,60456 -0,51091 -0,43969 -0,22499 -1,52157 -1,34597 0,291373 -0,49521 -2,76202 -2,23455 -3,16118 0,228054 0,405065 cAMP_Pathway_Lipolysis -0,1283 -0,01737 -0,033 -0,09856 0,73763 0,322888 -1,10674 -1,0566 -1,05288 -1,24966 0,205002 0,215002 -0,72136 -0,45399 -0,1187 -1,28901 -0,987 -0,59065 0,228608 0,405531 reactome_Classical_antibody_mediated_complem -0,15631 0,06575 -0,13906 0,314523 -0,01652 0,007671 -0,33937 -0,54451 -0,01561 0,621869 -0,48547 0,453466 0,298792 0,533357 -0,00069 1,952267 1,425888 1,415815 0,228492 0,405531 biocarta_y_branching_of_actin_filaments_Main_P 0,234567 -0,15583 -0,14157 -0,12439 -1,47659 -0,7946 -0,82651 -0,49017 -1,34941 -0,81142 0,775985 -1,01019 -0,69489 -0,55144 -0,30293 -6,33143 -5,44463 -3,37353 0,228784 0,405613 NCI_IGF1_Main_Pathway -0,03276 -0,1066 -0,32779 -0,40715 1,119234 -0,82249 -1,86858 -1,88362 -2,09578 1,302213 1,289997 1,195959 1,517369 0,926319 1,254956 -2,58351 -1,06456 -0,94255 0,22935 0,406386 reactome_Presynaptic_phase_of_homologous_DN -0,06926 -0,09448 -0,07915 0,228031 0,075021 0,339914 0,789191 0,931398 0,922568 1,138029 -0,59265 0,396677 0,147843 0,168532 0,152076 -0,38291 -0,31773 -0,42169 0,229672 0,406724 NCI_Integrin_linked_kinase_signaling_Pathway_(s -0,04831 -0,16829 -0,23355 -0,31673 -0,37598 -0,34075 0,038338 0,009735 -0,10658 -0,49309 0,396836 0,649996 -0,09724 0,137099 -0,08006 -2,30952 -2,23142 -1,51372 0,229847 0,406804 reactome_Hypusinylation_Main_Pathway -0,18287 -0,06327 0,000621 0,105442 -0,13446 -0,33654 -0,26904 -0,15932 -0,23903 0,401553 0,149935 -0,43665 -0,13121 -0,11404 0,144448 -1,26659 -0,76315 -0,69698 0,230498 0,407724 leucine_degradation 0,266419 0,149993 -0,03556 -0,24698 -0,14735 -0,88635 0,096924 0,326391 -0,42694 0,737002 0,697172 -0,0248 0,203715 0,027307 0,437987 -3,66917 -3,47896 -3,10591 0,231226 0,408779 NCI_N_cadherin_signaling_events_Pathway_(actin -0,06125 -0,08612 -0,13686 -0,15359 0,723693 0,030241 -0,60161 -0,63888 -0,91084 0,726575 0,802925 0,69885 0,080364 -0,19045 0,009802 -3,12543 -2,04662 -1,61643 0,231447 0,408938 biocarta_visceral_fat_deposits_and_the_metabol -0,00159 0,022476 -0,06966 -0,20336 0,298872 0,180299 0,06949 -0,02574 0,093458 -0,23318 -0,44274 0,190772 -0,16632 0,04664 -0,2486 -0,28826 -0,27049 -0,3576 0,232917 0,411302 PTEN_Pathway_Migration -0,98985 -0,04152 -0,05325 -2,32026 -2,48352 -0,22879 7,059303 6,9246 8,017753 -1,49832 -6,25354 -5,47027 1,574615 0,297328 0,312977 16,74307 16,68566 12,93001 0,23334 0,411815 KEGG_Ras_signaling_Main_Pathway -2,59868 -3,38859 -2,4382 -4,4813 -3,38622 -5,2717 -15,446 -15,8572 -15,2827 -3,87528 -7,47805 -0,09955 2,863632 3,362836 4,740845 -7,08786 -2,69992 2,192027 0,233998 0,412742 NCI_ErbB2_ErbB3_signaling_events_Pathway_(ap 0,071526 0,07814 -0,0385 -0,49264 0,108923 -0,27727 -0,0908 -0,00514 -0,4142 0,094299 -0,0261 0,462399 0,159434 0,07002 0,220223 -2,08827 -1,26723 -1,06584 0,235273 0,414522 NCI_Nephrin_Neph1_signaling_in_the_kidney_po 0,071526 0,07814 -0,0385 -0,49264 0,108923 -0,27727 -0,0908 -0,00514 -0,4142 0,094299 -0,0261 0,462399 0,159434 0,07002 0,220223 -2,08827 -1,26723 -1,06584 0,235273 0,414522 guanosine_deoxyribonucleotides_ide_novoi_biosy 0,226424 0,037244 -0,09481 -0,44676 -0,38438 0,056651 0,492484 0,672782 -0,1474 1,059459 2,037838 0,714404 0,664428 0,615965 0,976321 -4,31746 -3,38548 -2,93378 0,235937 0,415457 NCI_FAS_CD95_signaling_Pathway_(cell_migratio -0,07203 -0,04084 -0,19272 -0,36414 0,784835 -0,07219 -0,18884 -0,19755 -0,26423 0,609194 0,022992 0,686277 0,071765 0,160851 0,184763 -1,6186 -0,9275 -0,52277 0,236284 0,415833 NCI_CXCR3_mediated_signaling_events_Main_Pa -0,10195 -0,26233 -0,26789 -0,24089 1,030484 -0,59592 -1,40279 -0,83029 -2,28898 0,868349 2,607303 0,133772 -0,4383 0,309651 1,281197 -4,62449 -2,01003 -3,39586 0,23685 0,416594 biocarta_g_secretase_mediated_erbb4_signaling_ 0,038418 -0,07605 0,201459 -0,46851 -1,51984 -2,09233 -0,11896 0,025641 -0,19775 -0,17124 -0,44904 -1,47404 0,479987 0,262519 0,470137 1,539131 1,186945 1,117234 0,237174 0,416897 reactome_Na_dependent_glucose_transporters_ 0,056638 0,07656 0,031088 0,560261 -0,30673 0,531 0,006717 -0,04325 0,473496 -0,64912 -0,23716 -1,04645 0,385361 0,006156 -0,05129 0,612729 0,203043 0,186666 0,23729 0,416897 NCI_N_cadherin_signaling_events_Pathway_(regu 0,064181 -0,06976 -0,04467 -0,12078 0,980845 -0,10357 -1,04164 -0,94456 -1,36121 0,841156 1,055985 0,697736 -0,06751 -0,3642 -0,30243 -4,47939 -3,3084 -2,89986 0,237517 0,41706 biocarta_map_kinase_inactivation_of_smrt_corep 0,198917 -0,08804 -0,10272 -0,91235 -1,22067 -0,58146 -0,04486 0,235682 -0,43403 -1,33632 0,326639 -1,36091 -0,25292 -0,02075 0,226791 -3,35135 -2,12477 -1,53889 0,237868 0,417383 NCI_Effects_of_Botulinum_toxin_Main_Pathway -0,12797 -0,12963 -0,17692 -0,29429 -0,22814 -0,15444 -0,6767 -0,64557 -0,69805 -0,61705 -0,2069 -0,38219 0,540573 0,260967 0,172305 2,595787 2,181962 3,083152 0,23837 0,417383 NCI_IL12_signaling_mediated_by_STAT4_Pathway 0,035023 -0,0613 0,073115 0,32895 0,076979 0,068208 -0,16214 -0,06527 0,047963 -0,34019 -0,1756 -0,15913 -0,07345 0,101914 0,245658 0,435168 0,418776 -0,36667 0,238349 0,417383 NCI_IL12_signaling_mediated_by_STAT4_Pathway 0,035023 -0,0613 0,073115 0,32895 0,076979 0,068208 -0,16214 -0,06527 0,047963 -0,34019 -0,1756 -0,15913 -0,07345 0,101914 0,245658 0,435168 0,418776 -0,36667 0,238349 0,417383 NCI_IL12_signaling_mediated_by_STAT4_Pathway 0,035023 -0,0613 0,073115 0,32895 0,076979 0,068208 -0,16214 -0,06527 0,047963 -0,34019 -0,1756 -0,15913 -0,07345 0,101914 0,245658 0,435168 0,418776 -0,36667 0,238349 0,417383 biocarta_nf_kb_signaling_Main_Pathway 0,144591 -0,12324 0,09627 -1,17139 -1,24778 -2,92005 -4,4699 -4,03442 -4,64353 1,558078 -0,52375 1,954806 -0,06875 -0,91929 -0,71258 -2,14422 -2,39981 -1,93014 0,240001 0,420003 NCI_Arf6_trafficking_events_Pathway_(calcium_io -0,05741 -0,17209 -0,09454 0,116429 -0,41848 -0,75684 -0,81641 -0,92804 -1,31722 1,017874 0,28522 0,608165 0,348388 0,449792 0,341901 -2,92793 -2,17684 -1,99788 0,241114 0,421713 FAK_Pathway 0,407814 -0,77785 -1,03808 -1,2472 -0,28545 -1,73467 -2,61608 -1,86571 -5,19981 -0,04206 2,890047 1,281754 1,20999 1,38949 2,444251 -8,53207 -4,78384 -1,39465 0,241452 0,422066 biocarta_ctcf_first_multivalent_nuclear_factor_M -0,32428 -0,41519 -0,30931 -0,36985 -0,40493 -0,55219 0,70816 0,548275 -0,19081 0,46326 0,551363 0,572149 0,830357 1,007309 0,883856 -1,77604 -1,29449 0,085173 0,241644 0,422166 Akt_Signaling_Pathway_Genetic_Stability -0,05332 -0,18421 0,256345 -1,5636 -0,07065 -1,6985 -0,08558 -0,18031 0,129796 0,350055 1,383576 -0,08114 0,728481 0,719772 0,362431 0,119209 0,740366 0,780329 0,242532 0,423033 biocarta_bone_remodeling_Pathway_(osteoclast_ -0,34572 -0,23944 -0,22463 0,463041 0,58668 0,411102 -0,64431 -0,93904 -0,43093 -0,20059 -0,7083 0,219846 -0,13084 -0,18641 0,155853 0,607725 0,354382 0,353673 0,242453 0,423033 KEGG_Glyoxylate_and_dicarboxylate_metabolism 0,098824 -0,03818 -0,049 -0,99272 0,07846 -1,49164 0,552219 0,276012 0,54177 1,002843 0,736453 2,835202 -0,24409 -0,4854 -0,49697 -2,02043 -0,98248 -1,20457 0,242548 0,423033 reactome_SHC1_events_in_ERBB4_signaling_Mai -0,05668 -0,06921 0,310593 -1,45074 -1,28672 -1,89652 -1,94593 -1,92175 -1,71339 0,526553 0,991421 -0,66018 -0,14171 0,179089 -0,26624 -1,20162 -1,19016 -1,09103 0,242922 0,423448 phosphatidylethanolamine_biosynthesis_II 0,081515 -0,06615 0,039462 -0,27121 0,42278 -0,61271 -0,27117 -0,09575 -0,39894 0,154111 -0,01362 0,226426 -0,47628 -0,21123 -0,05598 -0,41738 0,225968 -0,16582 0,243194 0,423515 reactome_PECAM1_interactions_Main_Pathway -0,1791 -0,03792 0,110568 -0,09395 -0,35823 -0,13452 -1,45086 -1,71091 -1,7203 -0,571 0,647386 -0,09014 -0,1118 -0,13181 0,521095 -1,77307 -0,71849 -0,70586 0,243232 0,423515 D-imyoi-inositol_145-trisphosphate_biosynthesis -0,11105 -0,24022 -0,58613 -0,53916 -0,97334 -1,4861 0,812652 1,007302 0,303718 -1,44725 -0,48836 0,210005 0,495424 0,217516 0,961642 -1,76512 -1,50376 -1,07812 0,244171 0,424911 biocarta_nfat_and_hypertrophy_of_the_heart__M -0,29883 -0,54317 -0,20095 -1,92729 1,659244 1,655554 -2,19906 -2,22056 -1,9113 -1,08548 0,123406 -0,42806 0,426749 -0,24255 0,340649 -1,06301 -0,53405 0,288303 0,245005 0,426126 VEGF_Pathway_Gene_Expression_and_Cell_Prolif 0,026203 -0,06128 -0,04521 0,350471 -0,09734 -0,62455 -0,47755 -0,07042 -0,86668 -1,80311 0,744663 0,002901 0,220033 0,231977 0,560825 -0,69564 -0,56541 0,151579 0,245199 0,426224 glutathione-mediated_detoxification -0,46737 0,268558 0,205032 -3,85718 -2,99802 -2,93861 2,002051 2,015028 1,277243 2,18718 0,886664 1,416274 -1,01938 -0,7487 0,355778 -3,37001 -3,80475 -3,19353 0,246265 0,4276 reactome_Extrinsic_Pathway_Main_Pathway 0,116999 0,025918 0,166136 -0,48215 -0,71248 0,464041 0,376316 0,26631 0,451977 -0,54505 -0,51908 0,043193 0,009352 0,20532 -0,07786 -1,31997 -0,66862 -0,9159 0,246352 0,4276 reactome_Processing_of_DNA_ends_prior_to_en 0,123725 0,028412 0,029662 0,48612 -0,02976 -0,27516 0,182775 0,303632 -0,06377 -0,23963 0,104804 -0,53393 -0,23863 -0,17339 -0,26649 -1,51345 -0,56743 -0,4885 0,246402 0,4276 geranylgeranyldiphosphate_biosynthesis 0,028741 -0,03527 -0,02281 0,01264 -0,05806 0,237277 -0,0406 -0,03143 -0,1332 0,145625 0,315315 0,234735 -0,01538 0,023156 0,09042 -0,84351 -0,42491 -0,43373 0,247486 0,429243 Regulation_of_Repulsive_Axonal_Pathfinding -0,73567 -1,30673 -1,0788 -2,79406 -4,30608 -4,19098 -6,25984 -6,40873 -7,36602 -7,08979 -1,80476 -0,54661 -0,61031 -0,55835 0,156899 -10,3324 -6,63816 -4,44478 0,247879 0,429685 cAMP_Pathway_Glycogen_Synthesis -0,13998 -0,12964 0,043081 -0,57779 0,864747 0,706154 -0,94113 -0,80564 -0,93079 -2,10446 -0,32307 -0,08131 -1,03891 -0,72256 -0,22025 -1,34594 -1,14629 -0,66601 0,250176 0,432716 NCI_Arf6_trafficking_events_Pathway_(clathrin_c -0,06664 -0,1236 -0,08553 0,065506 -0,46516 -0,86154 -0,87388 -0,98827 -1,44095 1,04953 0,291285 0,656274 0,401076 0,546595 0,419406 -3,14169 -2,33604 -2,00636 0,249912 0,432716 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(ap -0,01808 0,038984 0,053496 -0,40625 -0,11887 0,053029 -0,56007 -0,45785 -0,62624 -0,15207 0,226533 -0,13169 0,11223 -0,00933 -0,15699 -0,92553 -0,99633 -0,77771 0,250184 0,432716 stearate_biosynthesis 0,01959 -0,04504 -0,02375 -0,94153 -0,96256 -0,67717 -0,26213 -0,37124 -0,492 1,534369 0,46409 0,775629 0,504969 0,382889 0,024985 -0,63436 -0,36444 -0,37317 0,249775 0,432716 folate_transformations 0,230143 0,095438 -0,18256 -0,71097 -0,63277 -0,824 -0,55234 -0,22976 -0,71228 0,245946 0,268597 -0,54511 0,190664 0,343752 0,362184 -3,09108 -2,44137 -1,84089 0,250335 0,432737 NCI_PLK3_signaling_events_Main_Pathway -0,00491 0,000871 -0,11216 0,566773 0,387691 0,045867 -0,18524 0,125968 -0,31539 0,890076 -0,44834 -0,08565 -0,11428 0,0295 0,217202 -0,20651 0,272878 -0,45964 0,250593 0,432944 reactome_Attenuation_phase_Main_Pathway -0,1609 -0,35752 -0,1688 -0,40036 -0,11309 0,439651 -0,83558 -0,59783 -1,29032 0,404758 0,705496 0,134366 0,082302 -0,31412 -0,34399 -2,34881 -2,30642 -1,22484 0,25095 0,43332 aspirin-triggered_lipoxin_biosynthesis -0,10575 0,100289 0,117501 -0,25555 -0,78326 -0,67069 0,002974 -0,04074 -0,07354 0,483459 -0,06243 -0,15748 0,097187 0,194707 0,360054 0,174474 0,289371 -0,09319 0,251855 0,434161 aspirin_triggered_resolvin_D_biosynthesis -0,10575 0,100289 0,117501 -0,25555 -0,78326 -0,67069 0,002974 -0,04074 -0,07354 0,483459 -0,06243 -0,15748 0,097187 0,194707 0,360054 0,174474 0,289371 -0,09319 0,251855 0,434161 aspirin_triggered_resolvin_E_biosynthesis -0,10575 0,100289 0,117501 -0,25555 -0,78326 -0,67069 0,002974 -0,04074 -0,07354 0,483459 -0,06243 -0,15748 0,097187 0,194707 0,360054 0,174474 0,289371 -0,09319 0,251855 0,434161 mTOR_Pathway_Mitochondria_Proliferation_and_ 0,010669 0,002331 -0,06066 -0,86649 -0,60097 -1,09477 -0,14038 -0,02619 -0,2692 0,332188 0,231152 0,115935 0,038339 -0,0125 0,079792 -0,9322 -0,43214 -0,24617 0,252845 0,435626 KEGG_D_Arginine_and_D_ornithine_metabolism_ 0,00197 0,146176 0,132876 0,214507 0,109759 0,208573 0,091478 0,049983 0,149941 0,360213 -0,10989 0,218568 -0,05179 0,006726 0,159 0,775789 0,086964 0,426597 0,253159 0,435925 HIF1Alpha_Pathway_p53_Hypoxia_Pathway -0,2742 -0,28597 -0,14821 -0,24176 0,981634 -0,64112 -0,24058 -0,22167 0,116134 0,225152 0,364121 2,487286 1,01142 0,602866 0,031876 2,190611 1,082918 1,969616 0,253354 0,436021 biocarta_activation_of_pkc_through_g_protein_c -0,23364 -0,13286 -0,1107 -0,00188 1,417992 -0,31378 -0,88689 -0,92892 -0,69802 1,091475 0,78176 -0,49293 0,034894 -0,08033 0,464442 2,192456 1,540545 2,471669 0,253497 0,436026 reactome_p130Cas_linkage_to_MAPK_signaling_f -0,31412 -0,19808 -0,12633 -1,11866 0,083699 -0,72507 -0,75858 -0,84818 -0,67759 -0,16315 0,148563 -0,9232 -0,09131 -0,3025 -0,80975 0,182295 -0,37685 -0,26739 0,253799 0,436064 reactome_Regulation_of_the_Fanconi_anemia_M 0,176996 -0,04293 0,12229 0,033734 0,2466 -0,01342 1,124906 1,280768 0,996189 -0,59675 1,018968 0,406372 -0,21059 -0,08957 0,011624 -2,54542 -1,63452 -1,10578 0,253753 0,436064 KEGG_Selenocompound_metabolism_Main_Path 0,244478 0,149659 0,164052 0,164683 0,225993 -0,21359 0,520845 0,608221 0,065139 -0,5315 0,035046 0,363087 -0,61951 -0,76532 -0,39927 -3,05544 -3,20116 -2,35298 0,254345 0,436762 FLT3_Signaling_Pathway_Transcription_via_ELK3_ 0,407223 -0,52753 -0,38108 -1,1782 -1,15707 -2,60709 -1,73618 -0,8483 -2,98277 -3,14103 2,556226 -0,27617 0,373827 0,014723 1,324594 -6,01895 -4,56912 -4,91294 0,254881 0,437441 glycine_biosynthesisdegradation -0,01949 0,056156 0,035623 -0,17156 -0,00316 -0,1628 0,045956 -0,0129 0,344009 0,598285 -0,41244 0,526758 0,118505 0,257139 0,279557 0,67183 0,273647 0,253436 0,257373 0,441474 progesterone_biosynthesis -0,195 0,012547 0,167193 -0,01482 -0,13369 -0,08175 0,010772 0,094304 0,28697 0,468305 -0,08142 -0,17765 -0,26497 0,124313 0,218224 0,600147 0,057621 0,154816 0,25772 0,441583 superoxide_radicals_degradation -0,02721 -0,02613 -0,10374 -0,38469 -0,28937 0,019858 -0,08777 0,161615 -0,16519 -0,36573 0,512381 0,176245 0,023199 -0,30658 -0,09281 -1,65591 -1,86565 -1,50547 0,25758 0,441583 NCI_EPO_signaling_Pathway_(beta_integrin_med -0,17413 -0,13983 -0,03474 0,063546 0,459134 0,484682 -0,41852 -0,50818 -0,44519 -0,7109 -0,09987 0,080072 -0,4765 -0,051 -0,29321 -0,58611 -0,28385 0,194988 0,258303 0,442339 PTEN_Pathway_Genomic_Stability -0,91031 -0,3493 -0,41926 -0,0441 -0,39914 0,753124 7,139926 6,865355 7,394548 -2,12363 -4,23786 -2,98325 0,167101 -0,50532 -0,45735 12,57745 12,54918 10,99454 0,258692 0,442761 KEGG_Ribosome_Main_Pathway 4,50151 1,193301 0,633905 -9,89544 -10,2319 -13,3445 10,17568 12,28188 5,011719 -7,66409 6,610717 2,75473 -1,55269 -0,97057 1,689133 -64,7002 -54,6785 -49,4675 0,259366 0,443249 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(D 0,070926 0,014995 0,065494 -0,44917 -0,10656 -0,25931 -0,39321 -0,20338 -0,42456 -0,05807 -0,18342 0,013025 0,203112 0,035525 -0,26979 -1,71821 -1,10773 -0,93217 0,259236 0,443249 NCI_IL3_mediated_signaling_events_Main_Pathw -0,1005 -0,38032 -0,17683 -0,53428 -0,34981 -0,2471 -0,22467 -0,40349 -0,34482 0,710941 0,061041 -0,4403 -0,02435 -0,67238 -0,21866 -0,62126 -0,2455 -0,19393 0,259404 0,443249 VEGF_Pathway -0,84614 -1,18571 -1,21659 -3,90379 -2,77191 -3,31776 -3,1438 -2,31047 -4,00163 -2,03018 0,641044 0,313444 1,802602 1,028757 2,485111 -9,45714 -5,96716 -4,36149 0,259715 0,443537 UMP_biosynthesis 0,068412 0,024059 0,082827 0,182203 0,504107 -0,23377 0,038292 0,095532 -0,0042 -0,26912 0,319894 0,413193 0,087536 -0,07942 0,055122 -0,65429 -0,5405 -0,38488 0,26004 0,44385 reactome_Free_fatty_acid_receptors_Main_Pathw -0,27103 -0,06595 -0,08483 -0,08117 0,238492 0,449582 0,19225 0,029888 0,700235 0,347125 -0,02477 -0,35572 -0,02604 0,009497 0,519629 2,085937 2,000253 2,106979 0,260264 0,443989 Regulation_of_Cell_Migration_and_Proliferation_ -0,49694 -0,61821 -0,75997 2,889869 2,258742 -0,65894 -1,67797 -1,76141 -1,53406 -2,49194 1,377521 2,282648 -0,80581 -0,91605 -0,23722 -1,97361 -2,27408 -0,60698 0,260604 0,444326 KEGG_Chagas_disease_American_trypanosomiasi 0,66375 0,034648 0,030431 -0,57282 0,274616 -0,17383 -4,45579 -4,21714 -4,65089 0,418227 1,43221 0,922305 1,088624 -0,62771 1,231162 -4,0695 -3,6468 -1,98922 0,260874 0,444542 KEGG_Fructose_and_mannose_metabolism_Main -0,03016 0,268403 0,432509 -0,59314 -0,91421 -0,17575 -2,30332 -2,08679 -2,04326 2,880389 1,098578 2,35258 0,785321 0,157118 0,200154 -0,14792 -1,71664 -0,31776 0,2614 0,444784 reactome_Glycogen_breakdown_glycogenolysis__ 0,08123 -0,17062 0,335176 -0,95654 0,223531 -0,99777 -0,9046 -0,5318 -1,17516 -0,92151 1,286082 0,471426 1,070465 0,136699 0,957477 -2,52399 -1,49582 -2,53661 0,261586 0,444784 reactome_TGFBR1_KD_Mutants_in_Cancer_Main -0,08192 -0,07527 -0,11554 -0,77384 -0,81586 -0,44127 -0,70143 -0,7865 -1,00396 0,111314 0,043771 0,458287 -0,13364 0,009317 -0,08925 -0,62006 -0,84211 -0,17296 0,261587 0,444784 reactome_TGFBR2_Kinase_Domain_Mutants_in_C -0,08192 -0,07527 -0,11554 -0,77384 -0,81586 -0,44127 -0,70143 -0,7865 -1,00396 0,111314 0,043771 0,458287 -0,13364 0,009317 -0,08925 -0,62006 -0,84211 -0,17296 0,261587 0,444784 lipoxin_biosynthesis 0,022321 -0,06119 0,132489 -0,04511 -0,40823 -0,24859 0,080149 -0,25473 0,150475 0,159285 0,569676 0,736099 0,359349 0,437335 0,405319 0,394652 0,718314 0,027762 0,263425 0,447664 IGF1R_Signaling_Pathway_Protein_Synthesis 0,348816 0,249353 0,104749 0,357153 -0,03946 -0,70241 -0,04725 0,283975 -0,70528 0,488565 0,334957 -0,46517 -0,64609 -0,25543 0,009387 -3,61525 -3,00613 -2,5248 0,264061 0,4485 HGF_Pathway_Regulation_of_Cytoskeleton_Cell_ 0,00804 -0,33184 -0,44809 -1,2298 -0,65217 -0,66738 0,213058 0,387717 -0,32128 -1,24252 0,110048 -0,08781 -0,64761 0,068281 -0,05911 -3,75914 -2,20045 -1,87215 0,264469 0,448949 NCI_ErbB2_ErbB3_signaling_events_Pathway_(ce 0,216589 0,041812 -0,04576 -0,15111 -0,78237 -0,01669 0,422326 0,692346 -0,09048 -0,2561 0,683616 0,338499 -0,04525 0,089746 0,107949 -2,6562 -2,26667 -2,00571 0,264666 0,449039 NCI_Trk_receptor_signaling_mediated_by_the_M -0,0242 -0,17138 -0,12835 -0,01661 -0,08668 -0,38207 -1,10611 -0,9635 -1,26057 0,325741 1,066996 0,445829 -0,27499 0,060293 -0,10319 -0,65921 -0,21139 0,021842 0,265403 0,449955 PTEN_Pathway_Cell_Cycle -1,1748 -0,47863 -0,49303 -0,94338 -1,19215 -0,12322 7,010394 6,9548 7,59945 -1,93451 -4,57506 -5,23907 0,257127 -0,66036 -0,32482 11,82021 12,54643 11,36081 0,26564 0,449955 PTEN_Pathway_Growth -1,1748 -0,47863 -0,49303 -0,94338 -1,19215 -0,12322 7,010394 6,9548 7,59945 -1,93451 -4,57506 -5,23907 0,257127 -0,66036 -0,32482 11,82021 12,54643 11,36081 0,26564 0,449955 reactome_Dimerization_of_procaspase_8_Main_ 0,038329 -0,03007 -0,0645 -0,58207 -0,62893 -2,18319 -1,27419 -0,93699 -1,12342 0,126763 -0,72916 1,01275 -0,135 0,255632 -0,24505 -0,61013 -0,55182 -0,28484 0,266015 0,450101 reactome_Regulation_by_c_FLIP_Main_Pathway 0,038329 -0,03007 -0,0645 -0,58207 -0,62893 -2,18319 -1,27419 -0,93699 -1,12342 0,126763 -0,72916 1,01275 -0,135 0,255632 -0,24505 -0,61013 -0,55182 -0,28484 0,266015 0,450101 MAPK_Family_Pathway_Translation -0,09729 -0,04865 -0,21495 0,107693 0,082472 -0,81166 -0,58013 -0,60637 -0,56918 -0,74258 -0,29709 -1,35487 0,666514 0,211574 0,521225 -0,03124 0,168819 0,760814 0,266193 0,450157 KEGG_Renal_cell_carcinoma_Main_Pathway -0,29852 -0,41565 -0,4879 -1,81676 -1,26611 -0,81014 -1,87738 -1,65336 -2,1079 0,13984 -0,4194 2,462778 0,388133 0,839383 1,023469 -6,23976 -4,30825 -3,55391 0,267737 0,451589 MAPK_Family_Pathway_Cytoskeleton 0,062271 -0,2609 -0,18498 0,298147 -0,19807 0,088757 -0,41001 -0,25745 -0,28798 0,661027 0,3705 0,096684 0,506771 -0,15518 0,307546 -0,65701 -0,35363 -0,30296 0,267361 0,451589 reactome_AKT_mediated_inactivation_of_FOXO1 -0,03539 -0,117 -0,04903 0,150988 0,527747 0,313231 0,173285 0,219361 0,022247 -0,20746 0,263043 -0,04772 -0,01541 -0,14394 -0,13319 -0,15806 0,035911 0,077179 0,267764 0,451589 reactome_Signal_transduction_by_L1_Main_Path -0,0563 -0,15635 -0,27161 -1,08569 -0,71932 -1,37397 -1,25397 -0,89375 -1,26298 -0,07799 -0,03874 -0,16856 -0,00231 -0,33872 -0,19477 -1,10779 -0,79226 -0,2084 0,267629 0,451589 the_visual_cycle_I_vertebrates 0,05006 -0,24933 0,04473 -1,11369 -0,22256 -1,03817 0,497604 0,858127 0,601628 -0,58552 -0,21365 -1,03148 0,599389 0,236248 -0,19269 1,087425 1,382245 0,992169 0,267417 0,451589 biocarta_attenuation_of_gpcr_signaling_Main_Pa -0,03599 -0,27141 -0,20115 -0,71147 -0,22102 -0,10685 -1,93863 -1,94421 -1,8712 -0,42093 -0,14192 -0,05486 -0,81689 -0,6553 0,019339 -2,45382 -2,28925 -1,70764 0,268772 0,453043 biocarta_activation_of_pkc_through_g_protein_c 0,032264 -0,07643 -0,02636 -0,12511 0,502642 -0,56262 -0,38247 -0,33452 -0,33803 0,374931 0,104056 0,047206 0,297389 -0,17204 0,32852 0,801719 0,547837 0,679959 0,269391 0,453841 biocarta_role_of_egf_receptor_transactivation_by -0,09285 -0,62188 -0,48383 -0,30407 -0,92542 -1,14177 -1,0171 -0,65748 -1,47866 -0,94907 0,018818 -0,31884 -0,15198 -0,79132 0,126315 -2,60792 -1,80112 -1,66047 0,2697 0,454117 biocarta_keratinocyte_differentiation_Main_Path 0,280019 -0,2877 -0,08596 -2,93196 -2,11919 -1,6492 -2,88663 -2,16609 -3,01815 -0,99587 -3,25848 -4,15562 0,609047 0,69596 0,920152 -4,08818 -2,00135 -1,43759 0,270407 0,455061 NCI_Signaling_events_mediated_by_Stem_cell_fa 0,019619 -0,45915 -0,54107 -1,60963 -0,21457 -0,78939 -4,76409 -4,54651 -5,70125 1,406415 1,636691 0,965957 -0,35331 -0,61204 0,571802 -7,57375 -7,69266 -6,63306 0,271735 0,457049 Role_of_KITLG_in_Haematopoiesis -0,75657 -0,83978 -0,86653 -0,03852 -1,71936 -3,12732 -6,20592 -6,42349 -7,60077 2,767441 1,805639 2,837492 -0,20061 0,866881 2,310548 -11,6899 -9,71876 -7,15143 0,272048 0,457328 reactome_FCGR_activation_Main_Pathway -0,13018 0,028722 0,07062 -0,02169 -0,23725 0,908557 0,220735 -0,17887 0,533738 0,996948 -0,15201 1,518398 0,234978 0,595671 0,277522 1,531756 0,766857 0,921867 0,272419 0,457458 tryptophan_degradation_to_2-amino-3-carboxym -0,01494 0,165722 0,132092 -0,47342 -0,68748 -0,19713 -1,80978 -2,30991 -1,67795 -1,17441 -0,29509 -0,7546 0,175051 -0,49401 -0,36524 0,646581 0,801345 -0,07453 0,272344 0,457458 phenylalanine_degradationtyrosine_biosynthesis 0,005943 0,051541 0,037358 0,16828 0,027438 -0,12514 0,413223 0,448853 0,451467 0,153658 -0,22044 -0,17501 -0,15134 -0,16605 -0,11388 0,1427 0,192918 0,011622 0,272624 0,457556 BRCA1_Pathway_Nucleotide_Excission_Repair 0,083864 -0,07145 -0,03963 0,230483 -0,1013 0,054805 0,098676 0,31394 -0,10788 0,64846 -0,01364 0,324457 0,35329 0,281775 0,226668 -0,06684 -0,37159 -0,15806 0,272978 0,457903 adenosine_deoxyribonucleotides_ide_novoi_biosy 0,079183 0,084535 -0,04546 -0,31565 -0,31698 0,099225 -0,25013 -0,21245 -0,70545 1,171059 1,781098 0,896813 0,599303 0,496131 0,75954 -3,47286 -2,98527 -2,59605 0,273661 0,458555 CMP_phosphorylation 0,070765 0,085571 -0,03586 -0,3775 -0,21078 0,139136 0,128311 0,19028 -0,42362 1,238293 2,206448 0,876395 0,654973 0,62128 0,683266 -3,69252 -3,42024 -2,88603 0,273604 0,458555 NCI_Regulation_of_RAC1_activity_Main_Pathway 0,347016 -0,00842 -0,01155 -3,06076 -1,05447 -1,73471 -2,3624 -2,27975 -2,74349 -2,52528 0,435881 -1,13556 -0,07695 1,343621 1,130044 -4,35908 -3,90266 -3,98373 0,275407 0,460985 reactome_Reduction_of_cytosolic_Ca_levels_Mai -0,13868 -0,10845 0,029907 0,229783 1,482562 0,176 -0,93503 -1,27501 -0,87724 -2,42149 -1,1714 -1,30458 -0,19426 0,252155 0,058626 1,059191 0,894762 1,281678 0,275359 0,460985 KEGG_Steroid_biosynthesis_Main_Pathway 0,349984 0,247456 -0,04269 1,037641 1,216786 0,93408 1,514101 1,849859 1,243155 1,161631 1,63432 1,647518 -0,47292 -0,43036 -0,62306 -4,94309 -3,60303 -3,33955 0,275878 0,461526 biocarta_t_cell_receptor_signaling_Pathway_(Pat -0,02838 -0,15546 -0,0206 -0,0274 -0,20171 -0,90681 -0,30932 -0,36239 -0,21409 -0,25121 0,010579 -0,66665 0,19047 -0,12793 0,112218 0,464492 0,707935 0,821355 0,276333 0,46179 tRNA_splicing -0,07017 -0,03429 -0,13757 -0,45659 0,589028 0,416858 0,268846 0,322397 0,155635 0,207567 0,342901 -0,34312 -0,31763 -0,30786 -0,3113 -1,24072 -0,89193 -1,14599 0,276267 0,46179 reactome_The_activation_of_arylsulfatases_Main -0,26017 -0,21807 0,107279 0,528092 0,056023 0,049954 -2,06819 -1,68525 -1,8177 1,694214 0,003777 0,059424 0,072332 0,133274 0,463436 -0,20457 -1,26416 -0,96568 0,276691 0,462141 biocarta_wnt_lrp6_signalling_Main_Pathway -0,11991 -0,00469 0,083314 -0,45839 0,443913 -0,13344 -0,53742 -0,4998 -0,2087 -0,97784 -0,31225 -0,14312 0,357644 0,048551 0,018495 -0,1009 0,221874 -0,04325 0,277838 0,463093 NCI_Signaling_events_mediated_by_Hepatocyte_ -0,32649 -1,11603 -1,55551 -3,71466 -2,27596 -3,22593 -7,59551 -6,46025 -9,0205 -2,87635 1,271461 -0,66959 2,102356 1,219744 2,234649 -8,79526 -4,3388 -2,34337 0,277868 0,463093 palmitate_biosynthesis -0,11159 -0,04991 -0,25495 -0,22043 -0,55716 0,385429 -0,97568 -1,06533 -1,33639 0,329919 0,515819 -0,40109 0,033062 0,176707 0,088005 -0,64243 -0,93986 -0,72686 0,278004 0,463093 reactome_Nonhomologous_End_joining_NHEJ__M0,172332 0,06027 0,032887 0,288563 -0,27088 -0,14036 -0,60678 -0,43581 -0,90309 -0,46485 0,273751 0,030974 -0,44184 -0,23356 -0,24833 -2,3445 -1,45594 -1,20844 0,277644 0,463093 reactome_Norepinephrine_Neurotransmitter_Re -0,1807 -0,53102 -0,0974 -0,61085 -0,63455 -1,39596 -2,86081 -2,86733 -2,60946 -2,48399 -2,28594 -1,89796 0,324516 -0,0347 0,411283 6,309236 5,868177 5,484202 0,277517 0,463093 KEGG_Peroxisome_Main_Pathway 0,777599 -0,46819 -0,41942 -1,83012 -0,48043 -1,95267 -1,46617 -0,2468 -3,13831 -3,16692 1,921183 4,839928 -0,33387 -1,87058 0,440411 -15,2273 -11,9919 -9,7458 0,278704 0,46401 reactome_Carnitine_synthesis_Main_Pathway 0,128953 -0,10421 -0,16828 -0,11639 -0,60407 -0,40218 1,581486 1,80648 1,247827 0,068839 0,184661 -0,16689 0,382636 0,176512 0,304095 -1,56927 -0,58769 -0,68605 0,278905 0,464096 Ephrin-mediated_Signaling_Events_During_Cell_A 0,419455 -0,01258 0,147419 -0,83841 -2,4149 -0,83313 -3,76954 -3,82465 -3,99453 -0,42876 0,574808 -1,2747 0,027359 0,150774 0,522672 -1,07953 -0,14794 2,548749 0,280115 0,464888 mucin_core_1_and_core_2_iOi-glycosylation -0,39728 -0,56024 -0,35323 -0,8102 0,931757 0,027726 1,584882 0,877878 1,424262 -0,16383 -1,41709 -0,46656 -0,1043 1,58282 1,163892 0,994718 0,920946 0,894908 0,279795 0,464888 NCI_S1P2_Pathway_(regulation_of_vascular_perm -0,08538 -0,14777 -0,1423 0,110397 -0,15544 -0,55387 -0,73794 -0,67814 -0,49969 -0,62705 0,301177 0,113212 0,0605 -0,23692 0,10338 -0,64518 -0,55976 -0,99439 0,27984 0,464888 PTEN_Pathway_Cell_Survival 0,048561 0,002127 0,135256 -0,31177 -0,8707 0,16864 0,568913 0,629485 1,132855 0,167491 -1,29856 -1,234 0,032368 0,080578 -0,12015 2,498448 1,417829 1,218811 0,280575 0,464888 reactome_Dopamine_Neurotransmitter_Release_ -0,41261 -0,78673 -0,46757 -0,04881 -0,37749 -0,67987 -3,15232 -3,12109 -2,79848 -2,70866 -2,06673 -1,3275 -0,10735 -0,51643 0,181166 6,477042 6,010625 6,489581 0,280538 0,464888 reactome_Glycogen_synthesis_Main_Pathway 0,361563 0,088268 0,315987 -0,31112 -0,36728 -2,59505 -0,56143 -0,2251 -0,97384 -0,09168 0,279864 0,783218 0,395129 0,600916 0,481473 -5,77425 -4,45997 -4,39767 0,280147 0,464888 reactome_Serotonin_and_melatonin_biosynthesi 0,000649 -0,01788 0,065379 0,197153 0,015428 0,085016 -0,10055 -0,23734 0,25546 -0,78062 -0,49938 -0,06163 0,160749 -0,28429 -0,0665 1,697807 1,41008 1,748913 0,279889 0,464888 reactome_Serotonin_Neurotransmitter_Release_ -0,41261 -0,78673 -0,46757 -0,04881 -0,37749 -0,67987 -3,15232 -3,12109 -2,79848 -2,70866 -2,06673 -1,3275 -0,10735 -0,51643 0,181166 6,477042 6,010625 6,489581 0,280538 0,464888 HMGB1_signaling_through_RAGE -0,16714 -0,65094 -0,38726 -2,52603 0,196273 -0,64065 -3,62586 -3,10881 -4,41997 -1,74578 1,057729 0,377536 1,445687 0,41989 1,70801 -2,82707 -1,84266 -0,62778 0,281042 0,465065 IL-2_Pathway_Gene_Expression_via_FYN_LYN_RP 0,135209 0,419375 0,274091 -0,49453 0,678686 -0,64605 -0,1607 -0,58786 -0,60047 0,723771 1,570661 1,4268 0,281578 -0,06204 0,159252 -0,45676 -0,38852 -0,51256 0,281279 0,465065 reactome_Synthesis_of_PIPs_at_the_Golgi_memb -0,21173 -0,06177 -0,25483 -0,23385 -1,18229 -0,46763 -0,15568 0,292875 -0,6923 -1,84279 -1,09093 -0,65118 -1,27701 -0,97915 -0,53795 -3,03132 -1,57201 -2,19886 0,280881 0,465065 TRAF_Pathway_Direct_Antimicrobial_Response_a -0,15982 0,142709 -0,00725 -0,52223 -1,23458 0,074156 0,253187 0,17279 0,162715 0,121758 -0,71155 -0,35121 0,262979 0,682513 0,501078 -0,95359 -1,01972 -0,88141 0,281269 0,465065 reactome_Acetylcholine_Neurotransmitter_Relea -0,26921 -0,47001 -0,32752 -0,08121 -0,82432 -1,71586 -2,56986 -2,53742 -2,44995 -2,54628 -1,9534 -2,02357 0,352367 -0,0632 0,19959 6,064433 5,456639 5,599845 0,281491 0,46517 BRCA1_Pathway_G1_S_arrest 0,134437 0,02553 -0,03551 0,239466 0,617266 -0,29119 -0,15043 0,111182 -0,51563 0,582869 0,298096 0,317843 0,003729 0,1215 -0,03219 -1,16034 -0,62109 -0,97235 0,282678 0,466884 reactome_Pre_NOTCH_Processing_in_Golgi_Main -0,23236 -0,22956 -0,08776 0,412447 1,347662 1,129078 0,285667 0,378728 0,477069 0,641132 -0,44118 -0,75253 0,390565 -0,22131 0,00992 1,319431 -0,24119 1,10953 0,283606 0,467958 reactome_Regulation_of_actin_dynamics_for_pha -0,23996 -0,81392 -0,73549 -1,91658 -2,29013 -3,18376 -2,57315 -2,30117 -3,12195 0,830862 -1,34302 2,154883 1,257272 1,434178 1,854898 -9,27231 -6,80087 -3,47471 0,283629 0,467958 biocarta_phospholipids_as_signalling_intermediar 0,007474 -0,12786 -0,1183 -0,0285 -0,3642 -0,75626 -0,71273 -0,55043 -0,87588 -0,30069 0,479541 0,633608 -0,13288 -0,28829 -0,06691 -0,5494 -0,55955 -0,16066 0,284908 0,468919 biocarta_phospholipids_as_signalling_intermediar 0,007474 -0,12786 -0,1183 -0,0285 -0,3642 -0,75626 -0,71273 -0,55043 -0,87588 -0,30069 0,479541 0,633608 -0,13288 -0,28829 -0,06691 -0,5494 -0,55955 -0,16066 0,284908 0,468919 NCI_Endothelins_Pathway_(regulation_of_vascula 0,007474 -0,12786 -0,1183 -0,0285 -0,3642 -0,75626 -0,71273 -0,55043 -0,87588 -0,30069 0,479541 0,633608 -0,13288 -0,28829 -0,06691 -0,5494 -0,55955 -0,16066 0,284908 0,468919 reactome_Activation_of_C3_and_C5_Main_Pathw 0,083176 0,115839 0,080377 0,286374 -0,06349 0,501196 0,132126 0,268502 0,245969 -0,13629 -0,94878 -0,00074 -0,34674 -0,39922 -0,40575 -0,71157 -0,91612 -0,38417 0,284964 0,468919 reactome_Sema4D_induced_cell_migration_and_ -0,19092 -0,33638 -0,55112 -1,13004 -0,6847 -0,79869 -1,40818 -1,18305 -1,77864 -0,7756 -0,50359 -0,81917 0,218713 0,379284 -0,15796 -1,31404 -1,12219 -0,49216 0,284689 0,468919 reactome_Xenobiotics_Main_Pathway -0,23311 0,089887 -0,2034 2,196565 1,371452 0,352524 -0,48673 -1,15443 0,814815 1,650942 2,363944 3,332677 0,256839 0,870624 0,536482 4,080054 2,207422 1,099272 0,286476 0,471158 biocarta_regulation_of_spermatogenesis_by_crem -0,02777 0,149752 0,095427 -0,57153 -0,83628 -0,67885 0,162244 -0,05429 0,063615 0,92708 0,02729 -0,40757 0,249704 0,164607 0,525649 0,028921 0,193189 -0,01302 0,286925 0,471399 PTEN_Pathway_Differentiation -1,156 -0,4243 -0,45137 -1,03249 -1,06306 0,065697 7,161949 7,068319 7,791915 -1,75448 -4,76164 -5,57122 0,372096 -0,52302 -0,28179 11,8021 12,59512 11,25553 0,286855 0,471399 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(po 0,139088 0,008821 -0,09293 -0,02395 0,027895 -0,31447 -0,58577 -0,49379 -0,77997 0,129112 0,544645 0,413886 0,010566 -0,08799 -0,08503 -2,25188 -1,82039 -1,36167 0,28895 0,474475 reactome_EPH_ephrin_mediated_repulsion_of_c -0,40204 -0,41789 -0,59306 0,056506 -1,12147 -2,15742 -4,59594 -4,92682 -5,44433 0,730889 3,871373 2,952077 0,62747 1,279691 1,676488 -0,76916 1,788951 1,566502 0,289524 0,475167 reactome_Glutathione_synthesis_and_recycling_M0,007447 -0,01355 -0,0649 -0,30781 -0,11847 0,051238 -0,25352 -0,14291 -0,45469 0,135483 0,606114 0,609441 0,405282 0,573662 0,29806 -1,1246 -0,49601 -0,61493 0,289853 0,475456 NCI_E_cadherin_signaling_in_the_nascent_adher 0,100422 -0,21079 0,092962 -1,94696 0,716387 -2,20127 -0,98096 -0,70545 -1,42687 -0,51549 0,202941 1,33816 -0,63803 0,19125 -0,064 -8,83174 -5,95068 -4,98941 0,290121 0,475645 reactome_Early_Phase_of_HIV_Life_Cycle_Main_ 0,041973 0,069889 0,055435 -0,2653 -0,13534 -0,27591 0,707349 0,772752 0,673576 -0,64805 0,474291 0,808483 -0,1178 -0,15361 0,034379 -0,3161 -0,10182 -0,24004 0,290405 0,475861 reactome_RIG_I_MDA5_mediated_induction_of_ 0,199698 0,097613 0,083919 0,466055 -0,22934 0,019606 0,087974 0,337145 0,046744 0,76025 0,248148 0,231088 -0,19371 0,26422 0,363016 -1,63242 -0,84597 -0,8954 0,291071 0,476701 biocarta_mcalpain_and_friends_in_cell_motility_M0,003573 -0,35548 -0,40051 -1,41565 -2,90665 -3,01844 -0,19011 0,162281 -0,55667 -0,78019 0,60176 -1,35707 0,635745 -0,23566 -0,11295 -0,88367 -1,00062 0,459895 0,292333 0,47834 KEGG_Chronic_myeloid_leukemia_Main_Pathway -0,49959 -0,80518 -1,10227 -2,44301 -0,56219 -1,13517 -4,88094 -4,14094 -6,14252 -1,00057 0,236764 2,242505 0,540783 -0,10264 1,06213 -6,81175 -3,97764 -2,18297 0,292405 0,47834 KEGG_Systemic_lupus_erythematosus_Main_Path 0,102335 0,15673 0,072799 0,151532 -0,16308 -0,03352 -0,90672 -0,85406 -0,403 0,191443 -1,16504 -0,33154 0,222316 0,386274 -0,56907 1,913177 1,188176 1,237152 0,292532 0,47834 biocarta_west_nile_virus_Main_Pathway 0,226082 0,136343 0,070985 0,031133 -0,3558 -0,01962 -0,31506 -0,06103 -0,64596 0,934215 -0,29664 -0,48084 -0,03042 -0,25335 -0,41096 -2,46986 -1,88815 -1,72894 0,29305 0,478434 biocarta_west_nile_virus_Pathway_(apoptosis) 0,226082 0,136343 0,070985 0,031133 -0,3558 -0,01962 -0,31506 -0,06103 -0,64596 0,934215 -0,29664 -0,48084 -0,03042 -0,25335 -0,41096 -2,46986 -1,88815 -1,72894 0,29305 0,478434 NCI_FGF_signaling_Main_Pathway 0,037413 0,342523 0,37531 0,532451 -0,00455 1,05817 0,724841 0,51864 0,958111 0,974599 0,496494 -0,43745 0,26105 0,261206 0,012317 1,943916 1,438369 0,883592 0,292945 0,478434 biocarta_caspase_cascade_in_apoptosis_Pathway -0,30269 0,20348 0,032075 0,025489 -0,45753 0,262375 0,924878 0,848578 1,203096 0,439995 0,465893 0,745349 0,169439 0,255522 0,432211 0,765664 0,37659 0,013787 0,293521 0,478952 reactome_Signaling_by_activated_point_mutants -0,46232 -0,23342 -0,13583 -0,46435 -0,26639 -0,3357 -0,61554 -0,96482 -0,26193 1,020705 -0,35001 0,243025 0,073011 -0,17034 -0,27415 -0,05054 0,220295 -0,62357 0,293861 0,479255 NCI_Plexin_D1_Signaling_Main_Pathway -0,14463 -0,26274 -0,40349 -0,22325 -1,51432 -0,65961 -2,59871 -2,36879 -3,13163 0,741138 0,492553 -0,55541 0,828481 1,252509 0,864491 -1,3355 -1,10847 -1,75324 0,29586 0,482263 ERK_Signaling_Pathway_Cell_Survival 0,165241 0,038883 -0,11778 -0,36205 -1,01993 -1,00381 -0,88472 -0,67307 -1,40156 -1,2767 0,427938 -0,65744 0,195535 0,154247 0,244553 -1,67989 -1,85151 -1,4385 0,296745 0,483453 KEGG_Inflammatory_mediator_regulation_of_TR -0,57762 -1,22069 -0,56708 0,562797 1,140986 -0,14366 -0,5218 -0,41214 0,320443 2,203844 1,765332 0,261256 0,610572 0,960437 2,577796 4,831529 5,677502 6,520169 0,297214 0,483657 reactome_Downstream_signal_transduction_Mai 0,076702 -0,26197 -0,30633 -0,99606 0,690591 -1,3886 -0,84147 -0,52325 -0,91668 0,537759 0,181136 0,739236 0,189692 -0,32439 0,419349 -4,37422 -3,0608 -2,47657 0,297336 0,483657 reactome_LDL_endocytosis_Main_Pathway 0,061875 0,224368 0,333683 -0,29466 -0,12394 -0,28339 0,126712 -0,24262 0,325087 0,563047 0,059436 -0,23975 0,417936 0,533705 -0,15613 0,490655 0,279984 0,073421 0,297304 0,483657 4-hydroxybenzoate_biosynthesis -0,03148 0,024319 0,006746 0,162311 -0,1479 0,138878 -0,00184 0,043466 0,230683 -0,1641 0,422144 0,383445 -0,0098 0,204529 -0,11389 0,446824 -0,0355 0,263747 0,297819 0,484182 KEGG_Regulation_of_actin_cytoskeleton_Main_P 0,860403 1,324296 0,781025 3,819722 -0,82 3,781448 4,807455 3,603306 5,025406 -7,2285 -3,48823 -7,74845 1,157171 -0,84331 -0,9794 4,705852 3,804575 -0,97416 0,29797 0,484182 NCI_FAS_CD95_signaling_Pathway_(release_of_cy -0,00961 0,022427 -0,07184 -0,0391 0,169882 0,44299 -0,53138 -0,42456 -0,66934 -0,34582 -0,0097 0,307692 -0,16611 -0,11657 -0,31019 -0,94925 -0,57915 -0,02875 0,298263 0,484405 biocarta_pten_dependent_cell_cycle_arrest_and_ 0,042359 0,010872 0,000608 -0,65897 -0,30227 -0,63251 0,145503 0,007345 -0,02527 -0,37342 -0,7441 -0,32692 0,496357 0,238983 0,479772 -0,66569 -0,41569 -0,51792 0,298481 0,484507 pyridoxal_5-phosphate_salvage -0,09119 -0,07215 -0,09926 -0,1776 0,141665 0,274622 0,059666 0,003538 -0,08118 0,562199 0,072658 0,908197 -0,0885 0,057769 0,033233 0,155572 0,017931 0,190686 0,298776 0,484732 CDC42_Pathway -0,14062 -0,50963 -0,28551 -1,97085 -2,33872 -1,65545 -2,78177 -2,28683 -3,45539 -4,60232 0,210854 -0,04743 0,27149 0,430657 0,900114 -5,48601 -2,63933 -1,91493 0,299511 0,485673 reactome_Acyl_chain_remodelling_of_PC_Main_ -0,14416 0,032399 -0,19782 -0,26325 -0,85193 -1,14695 -1,38937 -1,25755 -0,84554 -0,58923 -1,19052 -0,61627 -0,13926 0,034696 0,002818 -1,78016 -0,74815 -1,00141 0,300677 0,487055 reactome_Asparagine_N_linked_glycosylation_Ma 0,253085 0,162865 0,137742 -0,12743 -0,50502 0,535549 0,322281 0,323237 0,234748 0,646324 0,534925 0,491241 -0,11144 -0,07449 -0,00397 -2,87058 -2,62549 -2,26813 0,300662 0,487055 biocarta_rho_cell_motility_signaling_Pathway_(ac -0,14797 -0,14661 -0,16798 -0,27352 -0,60676 -0,59642 -0,632 -0,77172 -0,68305 0,350143 0,023874 0,087026 0,046059 -0,0969 -0,16494 -0,52239 -0,35088 -0,29977 0,301014 0,487168 NCI_EPHA2_forward_signaling_Main_Pathway -0,18447 -0,05132 -0,24029 -0,54286 0,437142 -0,84042 -1,2525 -1,23031 -1,54582 0,547959 0,769326 0,954232 0,519227 0,393842 0,152666 -2,53124 -1,88666 -1,97114 0,301442 0,487168 reactome_Beta_oxidation_of_palmitoyl_CoA_to_ 0,073 0,014935 -0,02741 -0,42707 -0,25967 -0,44764 0,253905 0,316866 0,068965 -0,32143 -0,23858 0,35789 0,17422 -0,0144 0,075063 -1,4041 -1,05123 -0,97241 0,301137 0,487168 reactome_IRAK2_mediated_activation_of_TAK1_c 0,169334 -0,02947 -0,02552 -0,93981 -1,24448 -1,21578 -0,04765 0,075573 -0,46701 -0,90259 0,098613 -0,2806 0,184096 0,301451 0,197663 -3,35641 -2,71169 -2,43654 0,301528 0,487168 reactome_IRAK2_mediated_activation_of_TAK1_c 0,169334 -0,02947 -0,02552 -0,93981 -1,24448 -1,21578 -0,04765 0,075573 -0,46701 -0,90259 0,098613 -0,2806 0,184096 0,301451 0,197663 -3,35641 -2,71169 -2,43654 0,301528 0,487168 KEGG_Mucin_type_O_Glycan_biosynthesis_Main_ -0,65941 -0,65482 -0,42406 -2,30844 -0,25697 -0,89631 0,930873 0,412586 0,614189 -0,6936 -1,64997 -2,37414 -0,91095 1,598752 1,115548 -1,35033 -0,83958 -0,19611 0,30249 0,488216 NCI_FAS_CD95_signaling_Pathway_(neuron_proje 0,082205 0,108153 0,007104 -0,41501 -0,0299 0,240969 -0,34701 -0,23621 -0,46175 -0,24056 -0,10327 -0,0471 -0,20628 -0,14166 -0,39693 -1,70677 -1,17345 -0,63804 0,302385 0,488216 KEGG_Butirosin_and_neomycin_biosynthesis_Ma -0,02894 0,044679 0,069429 -1,23948 -0,52977 -0,00054 -0,37847 -0,71947 -0,35856 -0,46615 0,226302 0,586197 0,379324 0,111825 0,397658 0,335881 0,124118 0,593798 0,30378 0,489536 reactome_2_LTR_circle_formation_Main_Pathwa -0,01426 -0,17469 -0,11069 -0,19273 -0,42249 -0,61002 -0,85329 -0,6354 -1,09291 -0,09874 0,428832 -0,21982 -0,39877 -0,28899 -0,1852 -2,84088 -2,20027 -1,82097 0,30377 0,489536 STAT3_Pathway_Anti-Apoptosis -0,04247 -0,11515 -0,07179 0,099435 0,551333 -0,1149 -0,32823 -0,37378 -0,26767 0,58752 0,202328 0,147986 -0,05481 -0,00482 0,141539 -0,39562 -0,3268 -0,49494 0,303568 0,489536 NCI_CXCR4_mediated_signaling_events_Pathway_ 0,053194 -0,14815 -0,06275 -0,57005 -0,32087 -0,21555 -0,19888 -0,10573 -0,5005 -0,08693 -0,17174 -0,24723 0,14652 0,334429 0,207214 0,430214 0,556274 0,978916 0,30495 0,490147 NCI_Syndecan_1_mediated_signaling_events_Pat -0,68002 -0,75047 -0,22677 -1,73949 -2,26175 -2,10081 -0,27736 -0,97508 0,93213 -2,12646 -1,45408 -0,21403 0,201483 0,440331 0,760274 2,941996 2,306135 0,822496 0,305103 0,490147 NCI_Syndecan_1_mediated_signaling_events_Pat -0,68002 -0,75047 -0,22677 -1,73949 -2,26175 -2,10081 -0,27736 -0,97508 0,93213 -2,12646 -1,45408 -0,21403 0,201483 0,440331 0,760274 2,941996 2,306135 0,822496 0,305103 0,490147 NCI_Syndecan_1_mediated_signaling_events_Pat -0,68002 -0,75047 -0,22677 -1,73949 -2,26175 -2,10081 -0,27736 -0,97508 0,93213 -2,12646 -1,45408 -0,21403 0,201483 0,440331 0,760274 2,941996 2,306135 0,822496 0,305103 0,490147 Nitric_Oxide_Pathway_in_Skeletal_Muscle -0,02909 0,028891 -0,1872 -2,52931 -1,23311 -1,83566 -1,20618 -1,50767 -0,01152 -1,31191 -1,30663 -0,40437 1,417043 0,358673 0,870955 2,178168 1,866833 2,698667 0,304808 0,490147 p53_Signaling_Pathway_Inhibition_of_IGF1R_mTO 0,0085 -0,02724 -0,02963 0,332899 -0,00847 0,104167 0,080666 0,07828 0,040808 0,308876 0,180739 0,071281 0,209676 0,107608 0,200128 0,179443 0,132705 -0,00295 0,304677 0,490147 reactome_GAB1_signalosome_Main_Pathway -0,00672 -0,17069 -0,32267 -0,75634 -0,55527 -0,70064 -0,21691 -0,14787 -0,54045 -0,84198 0,448345 -0,12797 0,330833 0,310617 0,757844 -1,87688 -0,88639 -0,47302 0,305581 0,490663 reactome_Vitamin_B2_riboflavin_metabolism_Ma -0,2811 -0,25977 -0,03964 -1,21944 -1,3915 -1,7332 -0,20637 -0,30859 -0,39507 0,29086 0,146642 1,307357 -0,07505 0,205105 0,152152 -0,88362 -1,25158 -0,88333 0,305942 0,490988 biocarta_role_of_pi3k_subunit_p85_in_regulation 0,138639 -0,08251 0,046881 -0,29347 -0,21265 -0,07085 -0,02155 0,049204 -0,28645 -0,40051 -0,42557 0,10977 0,232888 0,471398 0,28351 1,128417 1,243252 1,487196 0,306187 0,491129 Interleukin-8-induced_Cell_Adhesion_and_Migrat 0,156198 -0,2635 -0,06861 1,310124 0,597945 -0,07508 -1,53503 -1,55517 -1,39757 0,36924 0,656848 -0,17245 0,309279 0,378924 0,395305 0,251907 0,612372 0,65955 0,306422 0,491254 KEGG_Glycosaminoglycan_biosynthesis_chondroi 0,01078 -0,30876 -0,27544 0,51472 -0,56434 -0,23421 -0,8018 -0,81856 -1,20504 -2,73511 -1,97927 0,072758 -0,18802 0,005052 0,552021 -0,32277 1,447443 -0,06456 0,307378 0,492533 reactome_Prolactin_receptor_signaling_Main_Pat -0,03162 -0,02046 0,036751 -0,06669 -0,48669 -0,33247 0,353448 0,230324 0,289404 1,349352 -0,56188 0,056154 -0,33377 -0,37509 -0,09689 -0,78332 -0,47882 -0,03254 0,30778 0,492923 NCI_ALK1_signaling_events_Pathway_(endothelia -0,09101 0,008694 -0,06847 -0,36684 -0,52506 -0,33987 -0,97165 -0,98944 -1,3085 -1,35696 -0,28406 -0,23551 0,03482 0,04279 0,158461 -1,07408 -0,53186 0,170062 0,307968 0,492971 reactome_Inositol_transporters_Main_Pathway 0,055352 0,162541 0,161342 0,85381 -0,24649 0,686433 0,12522 0,075403 0,630924 -1,30467 -0,98181 -1,44363 0,263588 -0,18548 -0,20064 0,900186 0,353102 0,554068 0,308412 0,493402 reactome_Synthesis_of_Dolichyl_phosphate_Mai -0,11002 -0,16644 -0,16963 -0,08514 0,002279 -0,40959 0,181034 0,211631 0,029175 0,051105 -0,24132 -0,32411 -0,28063 -0,35621 -0,03293 0,234172 -0,13081 -0,00718 0,308554 0,493402 biocarta_cd40l_signaling_Main_Pathway 0,332514 0,204061 0,198488 -0,06262 -0,53206 0,205487 -0,07771 -0,11606 -0,05522 0,144772 -0,0871 -0,15708 0,30251 -0,06582 0,30285 -0,83515 -1,10692 -0,50241 0,309419 0,493517 biocarta_cd40l_signaling_Pathway_(Pathway_pro 0,332514 0,204061 0,198488 -0,06262 -0,53206 0,205487 -0,07771 -0,11606 -0,05522 0,144772 -0,0871 -0,15708 0,30251 -0,06582 0,30285 -0,83515 -1,10692 -0,50241 0,309419 0,493517 Hedgehog_Signaling_in_Mammals_Pathway -0,56765 -0,48424 -0,82566 1,427425 2,656011 0,768336 -2,4931 -2,3254 -2,14687 -1,97917 -0,35082 -0,65872 -0,41663 -0,1894 -0,14455 1,968801 0,497826 2,2019 0,309202 0,493517 KEGG_HIF_1_signaling_Main_Pathway -0,3172 -0,24051 -0,48236 -0,3521 -0,70825 -4,01562 0,245735 0,748948 -0,17071 1,020039 0,861351 -0,66994 -0,16045 -1,17697 0,380453 -2,45735 -0,29358 0,639407 0,309344 0,493517 NCI_Signaling_events_mediated_by_focal_adhesi 0,164928 0,133189 0,223932 -0,27701 -0,24224 0,086641 0,110191 0,3217 -0,20755 -0,26419 0,409434 0,072365 0,535425 0,498159 0,503684 0,652878 1,124066 1,392377 0,308867 0,493517 NCI_Nongenotropic_Androgen_signaling_Pathway 0,075399 -0,05421 -0,15748 -0,38217 -0,50378 -0,18066 0,346054 0,510091 0,071123 -0,17519 -0,21235 -0,11379 -0,26752 -0,07 -0,07051 -1,55781 -1,21855 -0,78039 0,309761 0,493689 reactome_NGF_independant_TRKA_activation_M -0,12341 -0,21365 0,036732 0,576998 0,695613 1,212204 0,370761 0,324468 0,532795 0,001223 -0,11437 0,302162 -0,0009 0,186489 0,335674 0,628115 0,992784 0,79518 0,309843 0,493689 ILK_Signaling_Pathway_Induced_Cell_Proliferatio 0,392306 -0,00251 0,084378 0,019335 0,095667 0,173713 0,051005 0,407552 -0,11519 -0,42732 0,456155 -0,2983 0,040155 0,037113 0,020004 -0,23771 -0,52108 0,00298 0,310351 0,494245 NCI_Arf6_trafficking_events_Pathway_(cell_adhes -0,0158 -0,05935 -0,16771 0,291924 -1,19631 -0,18188 -2,86131 -2,74524 -3,36333 1,033019 0,707563 0,419997 0,398078 0,484287 0,05406 -2,29426 -2,42351 -2,56613 0,31105 0,495105 KEGG_Endometrial_cancer_Main_Pathway -0,40294 -0,53552 -0,75429 -0,90954 -0,40556 -0,68227 -0,06666 0,191565 -1,08023 -0,45439 0,317533 2,546377 -0,45979 -0,32595 0,384777 -6,17547 -3,73469 -2,76088 0,312262 0,49678 fatty_acid_alpha-oxidation 0,023905 -0,09368 -0,00463 -0,16577 0,143476 -0,03162 -0,03905 0,10322 -0,02449 -0,15114 0,509658 0,166248 -0,02853 -0,24201 -0,19119 -1,31051 -1,06489 -0,9242 0,313221 0,497589 NCI_LPA_receptor_mediated_events_Main_Pathw 0,006675 -0,60778 -0,77036 -1,03342 -0,57226 -2,30463 -1,30749 -1,5048 -1,71093 0,104642 0,198705 -0,63142 -0,62264 -2,36049 -0,91967 -9,49864 -6,9404 -5,90316 0,313182 0,497589 reactome_SRP_dependent_cotranslational_prote 3,365634 0,97318 0,420392 -7,74917 -9,6999 -12,1988 7,91839 9,517691 4,355825 -6,68275 6,455631 4,47922 -2,20359 -1,6545 1,066834 -54,3925 -45,8768 -38,4068 0,31325 0,497589 reactome_Signaling_by_activated_point_mutants -0,26068 -0,2933 -0,10628 -1,01886 -0,91214 -1,38903 -0,71136 -0,85245 -0,29669 -0,17825 -0,38081 0,400721 0,125594 0,044209 0,11678 -0,30605 -0,03724 -0,51882 0,314037 0,498587 KEGG_N_Glycan_biosynthesis_Main_Pathway 0,347782 -0,54532 -0,33512 0,22987 0,138778 -0,96148 -0,72087 -0,28878 -1,97373 1,13527 4,322744 0,971612 -0,85837 -1,23975 -0,81112 -10,9236 -9,38899 -8,86425 0,314336 0,498806 biocarta_activation_of_camp_dependent_protein -0,7449 -0,07253 -0,05372 -1,33239 0,233989 0,062567 -1,50585 -2,3629 -0,576 3,486206 1,984049 -0,4859 -0,25786 0,885777 0,682171 1,225777 -0,25691 0,622839 0,314797 0,499284 reactome_G2_M_DNA_damage_checkpoint_Main 0,121618 -0,01516 0,006325 0,673749 0,695222 0,544615 -0,00645 0,259647 -0,23043 0,473049 0,711471 0,116676 -0,14384 -0,40816 -0,39448 -1,43609 -0,8676 -0,62055 0,315102 0,499513 reactome_Inhibition_of_TSC_complex_formation_ -0,05994 -0,0202 -0,03131 -0,38832 -0,4357 -0,35673 -0,2478 -0,22428 -0,27606 -0,40118 0,80185 -0,07019 0,134633 -0,05736 0,040007 -0,05389 -0,0449 -0,30251 0,316388 0,501297 coenzyme_A_biosynthesis -0,01037 -0,05346 0,126027 0,429761 -0,4986 -0,28671 0,141639 0,099565 0,153484 -0,1456 0,054537 0,082971 0,513039 -0,01385 -0,14742 -0,47322 -0,63723 -0,86667 0,316784 0,501669 biocarta_nitric_oxide_signaling_Main_Pathway 0,026718 0,236712 0,244941 2,03746 1,631886 1,543789 0,804172 0,934465 1,089546 1,936881 0,87677 -0,43434 0,200394 -0,16164 -0,18588 4,049948 3,96057 3,530626 0,317449 0,501702 NCI_BARD1_signaling_events_Pathway_(DNA_dam0,100595 0,03242 0,035579 0,352745 0,434231 0,377147 -0,05115 0,157846 -0,22585 0,075248 0,595761 0,27604 -0,26625 -0,23772 -0,14453 -1,1216 -0,78082 -0,58915 0,317319 0,501702 NCI_IL8_and_CXCR1_mediated_signaling_events_ 0,00839 0,125834 0,000869 0,074982 0,124376 0,581567 -0,88918 -1,12174 -0,65727 0,446759 -0,00283 -0,52991 -0,31532 -0,30811 -0,18697 0,51059 0,764176 0,414559 0,317339 0,501702 NCI_Syndecan_1_mediated_signaling_events_Ma -0,8644 -0,93593 -0,42243 -2,79158 -3,19797 -2,78047 -2,17369 -2,82094 -0,85652 -1,64686 -0,82812 0,460758 0,405889 0,571733 0,7976 1,529276 0,816667 -0,27749 0,317432 0,501702 Calcium2+_Signaling 0,130041 -0,1774 -0,26311 -0,11632 -0,2373 -0,44783 -0,90933 -0,72137 -1,60697 -2,10011 -0,43813 -2,19635 -0,26143 -0,69539 -0,02669 -0,80686 -0,19822 0,329568 0,31764 0,501748 biocarta_stress_induction_of_hsp_regulation_Pat -0,04192 -0,07132 -0,01569 -0,23771 -0,08025 0,238032 -0,28922 -0,22182 0,118678 -0,03205 0,092266 0,084422 0,178505 -0,04416 -0,07046 0,027 0,345963 0,503356 0,319287 0,503839 biocarta_stress_induction_of_hsp_regulation_Pat -0,04192 -0,07132 -0,01569 -0,23771 -0,08025 0,238032 -0,28922 -0,22182 0,118678 -0,03205 0,092266 0,084422 0,178505 -0,04416 -0,07046 0,027 0,345963 0,503356 0,319287 0,503839 serotonin_and_melatonin_biosynthesis 0,14127 -0,09342 0,218107 -0,10536 -0,86514 -0,41063 -1,5502 -1,75154 -1,2724 -0,28509 -0,78545 -0,22345 0,425408 0,169112 0,366967 1,096476 0,865006 1,331281 0,320027 0,504752 Akt_Signaling_Pathway_Elevation_of_Glucose_Im -0,0916 -0,20838 0,373081 -1,37555 0,371393 -1,26673 0,22418 0,094386 0,404121 0,009285 1,327149 -0,21552 0,579088 0,540815 0,396363 0,101344 0,837496 0,770875 0,320518 0,505271 biocarta_rho_cell_motility_signaling_Main_Pathw -0,40114 -0,24246 -0,07455 -1,92825 -2,67177 -1,88872 -1,52902 -2,00399 -1,49705 -1,08247 0,430004 0,81104 0,666056 0,274179 0,578796 0,510198 -0,49554 -0,66214 0,321188 0,50607 guanosine_nucleotides_ide_novoi_biosynthesis 0,201724 -0,09312 -0,11618 -0,58498 -0,65034 -0,5689 0,538811 0,772315 -0,06654 1,623036 2,545126 1,406566 0,760666 0,841203 1,138071 -5,53242 -4,39349 -3,99977 0,321571 0,506161 NCI_Signaling_events_mediated_by_VEGFR1_and 0,380317 -0,94037 -1,11399 -1,85657 -0,13023 -0,9346 -7,06076 -6,23406 -8,29599 3,452502 0,680358 0,947683 0,121396 -0,14787 0,65311 -8,10775 -6,52827 -4,76348 0,321484 0,506161 reactome_DNA_Damage_Telomere_Stress_Induc 0,078741 -0,39104 -0,80598 1,126794 -0,1836 -1,10663 3,94949 4,733369 2,702025 2,593194 1,031856 0,537785 -0,26083 -0,57018 0,927169 -5,59477 -2,59878 -3,47013 0,322189 0,506878 reactome_Activation_of_the_phototransduction_ -0,08967 -0,08376 0,054018 0,567705 1,192073 0,303157 0,368664 0,045518 0,983851 1,5515 0,883893 -0,77515 -0,41311 -0,68481 -0,68313 1,393168 0,059045 1,292396 0,322652 0,507351 biocarta_activation_of_csk_by_camp_dependent_ -0,60337 -0,32982 -0,19899 -0,74075 0,098041 -0,20838 -1,90313 -2,55872 -1,82544 2,485592 1,323415 -0,92439 0,595499 1,90365 1,324825 -0,19007 -1,47307 -0,98343 0,322947 0,507558 GDP-L-fucose_biosynthesis_II_from_L-fucose 0,032652 -0,02017 -0,05243 0,035463 -0,24522 0,354709 0,182349 0,266712 0,122655 0,320098 -0,00788 -0,10762 0,249022 0,054936 0,097951 -0,4142 -0,05287 0,131099 0,323836 0,508698 reactome_betaKlotho_mediated_ligand_binding_ -0,09221 -0,07457 -0,03871 -0,19057 -0,08129 0,152497 -0,09775 -0,19307 0,27709 -0,16055 -0,01875 -0,30941 -0,05321 0,323335 -0,19556 0,8404 0,615652 0,709469 0,324243 0,509081 biocarta_pkc_catalyzed_phosphorylation_of_inhib -0,07539 -0,44999 -0,07028 1,39011 0,618437 0,230157 -1,30939 -1,77041 -1,59846 -0,77393 0,179018 0,052172 -0,14883 -0,69371 0,021236 0,069619 -0,22853 0,421931 0,324749 0,509486 PTEN_Pathway_DNA_Repair -0,7196 -0,20027 -0,29384 0,067175 -0,27899 1,396797 7,84556 7,750374 8,072527 -1,85657 -5,25083 -2,96589 0,34206 0,043987 0,113845 12,42158 12,72394 11,46969 0,324828 0,509486 biocarta_multiple_antiapoptotic_pathways_from_ 0,115403 -0,14737 -0,15555 -0,16241 -0,10779 -0,51012 -1,39919 -1,10934 -1,45161 0,186868 -0,27443 0,137829 -0,01086 -0,13354 -0,12967 -1,73217 -1,20897 -0,67269 0,325543 0,509838 KEGG_Small_cell_lung_cancer_Main_Pathway -0,34267 -0,55884 -0,36836 -2,866 -1,82858 -1,13774 -3,36564 -3,26586 -4,05838 3,56742 -0,31738 2,949326 -0,84905 -0,40019 -0,0223 -2,55151 -2,69468 -2,38067 0,325312 0,509838 KEGG_Synaptic_vesicle_cycle_Main_Pathway -0,15787 -0,06377 -0,2143 0,103358 -0,10534 -0,12682 -1,68341 -1,69035 -1,6536 -1,01363 -0,55886 -0,52007 0,264753 0,364945 0,13576 2,844159 2,470979 3,849544 0,325508 0,509838 CDK5_Pathway_in_Central_Nervous_System -0,82828 -0,82496 -0,98977 -1,0565 -0,41783 -0,61336 -4,68759 -4,25803 -4,6595 -0,7959 0,770099 2,348741 -0,60169 -0,19543 0,398251 -4,46857 -2,69502 -2,75166 0,326667 0,511084 reactome_ATP_sensitive_Potassium_channels_M 0,027806 0,054611 0,239098 -0,45599 0,449891 -0,07429 0,606794 0,746934 0,725309 0,629343 -0,00462 -0,12989 0,404036 0,075985 0,306731 0,780411 0,613201 0,514053 0,326597 0,511084 NCI_Stabilization_and_expansion_of_the_E_cadh -0,08899 0,153502 0,047202 0,441354 0,044749 -0,308 -1,06847 -1,22477 -1,11941 -0,10961 0,841395 0,300878 -0,30823 0,115344 -0,07324 -2,23788 -1,06118 -1,05222 0,326831 0,511084 reactome_GP1b_IX_V_activation_signalling_Main -0,13589 -0,15022 -0,07192 -0,23314 -0,6291 -0,27212 -0,25487 -0,51303 0,183211 0,581474 0,440991 -0,04263 0,246299 -0,13157 0,11948 -0,27427 -0,31978 0,13327 0,327126 0,511288 NCI_CXCR4_mediated_signaling_events_Pathway_ -0,03145 -0,05789 -0,06576 -0,03331 -0,26203 -0,26062 0,045073 0,035593 0,048906 -0,24123 -0,17729 0,025834 -0,14597 -0,09257 -0,16758 -0,29038 -0,11813 -0,01275 0,328114 0,512575 NCI_LPA_receptor_mediated_events_Pathway_(c 0,415805 -0,03885 -0,10601 0,399073 -0,7121 0,207287 0,82116 0,6938 0,547692 0,087771 0,950694 0,005463 -0,56192 -1,2997 -1,02626 -5,18402 -4,74507 -3,86886 0,328282 0,51258 wybutosine_biosynthesis 0,09889 0,123971 0,007504 0,020834 0,061703 -0,89894 0,35715 0,597239 0,073657 -0,40989 -0,12757 0,51323 0,282178 -0,01142 0,245793 -1,40483 -0,95187 -0,7663 0,32846 0,512602 reactome_PI_3K_cascade_Main_Pathway -0,66069 -0,43157 -0,28567 -1,06988 0,240262 0,027715 -1,12085 -1,50467 -0,03255 0,071379 -1,21873 -0,20433 -0,33896 -0,08613 -0,25285 -0,84042 -0,45706 -0,27086 0,329182 0,513471 biocarta_erk1_erk2_mapk_signaling_Main_Pathw -0,2811 -0,42432 -0,52227 -1,52961 -1,45072 -1,83473 -1,44792 -1,52242 -1,4856 0,245443 1,571622 0,750421 0,452519 -0,10951 0,745137 -1,10351 -0,64332 -0,24463 0,330135 0,514701 catecholamine_biosynthesis -0,12405 -0,00092 -0,01465 0,142131 -0,23413 0,048971 -0,19018 -0,03366 0,429079 -0,80911 -0,35603 -1,06788 -0,02075 -0,20078 -0,44994 1,228522 1,500726 1,887488 0,331223 0,515295 NCI_EPO_signaling_Pathway_(cell_proliferation) 0,15748 0,146824 0,064917 -0,30541 -0,31753 0,049426 -0,09628 -0,08871 -0,2912 -0,47464 0,212756 -0,30337 -0,15021 -0,12242 -0,011 -1,13186 -0,64633 -0,97928 0,331344 0,515295 NCI_Signaling_events_mediated_by_focal_adhesi 0,081542 0,077688 0,03105 -0,30065 -0,34319 -0,06612 0,406729 0,633525 0,134457 -0,52614 0,021304 0,171174 0,283427 0,220353 0,315155 -0,84903 -0,17097 -0,1764 0,331068 0,515295 purine_nucleotides_degradation 0,01413 -0,09076 -0,11976 0,485732 -0,01889 -1,15232 0,961115 1,096422 0,690549 0,16711 0,104568 -0,05613 0,448712 0,208972 0,429308 -0,76574 -0,84461 -0,47244 0,330946 0,515295 reactome_Catecholamine_biosynthesis_Main_Pat -0,12405 -0,00092 -0,01465 0,142131 -0,23413 0,048971 -0,19018 -0,03366 0,429079 -0,80911 -0,35603 -1,06788 -0,02075 -0,20078 -0,44994 1,228522 1,500726 1,887488 0,331223 0,515295 NCI_Angiopoietin_receptor_Tie2_mediated_signa 0,057119 -0,16926 -0,25531 -0,85526 -0,89966 -0,59007 -2,28469 -2,42403 -2,39471 1,144713 -0,1523 -1,10622 0,147099 -0,30719 -0,06326 -0,8373 -0,44984 0,493468 0,331511 0,515298 reactome_Cleavage_of_the_damaged_pyrimidine -0,09404 -0,06315 -0,03581 0,020732 -0,31104 0,289485 0,12667 -0,0124 0,11043 0,399125 0,128886 0,341407 -0,02963 0,046923 -0,0863 -1,47688 -0,90318 -0,39659 0,332939 0,517001 reactome_Recognition_and_association_of_DNA_ -0,09404 -0,06315 -0,03581 0,020732 -0,31104 0,289485 0,12667 -0,0124 0,11043 0,399125 0,128886 0,341407 -0,02963 0,046923 -0,0863 -1,47688 -0,90318 -0,39659 0,332939 0,517001 NCI_Regulation_of_nuclear_SMAD2_3_signaling_ -0,05959 -0,10127 -0,1192 0,261332 -0,11971 -0,02485 -0,24838 -0,26581 -0,2421 -0,09801 0,281304 0,283868 0,006815 0,129559 0,115156 0,014936 -0,36014 -0,07449 0,334177 0,518408 reactome_Proton_oligopeptide_cotransporters_M 0,007366 -0,0949 -0,04464 -0,57564 -0,24118 0,042563 0,944751 1,027904 0,876739 -0,3912 0,040975 0,119062 0,116615 0,243972 -0,10849 -0,46587 -0,6871 -0,73104 0,33407 0,518408 NCI_Integrins_in_angiogenesis_Pathway_(angioge -0,0825 -0,18281 0,046799 -2,7901 -2,74816 -2,85113 -3,2732 -3,22552 -3,39008 1,29151 -0,55314 -0,41448 0,720733 0,934377 0,759463 -0,74919 -0,22995 -0,22255 0,335216 0,519761 C20_prostanoid_biosynthesis -0,18233 0,231876 0,022047 -1,24833 -1,01733 -1,04217 -0,37065 -0,52359 -0,12542 -0,4014 -0,02775 0,704345 0,345151 0,568652 0,794901 0,433011 0,06751 0,492951 0,336331 0,52123 reactome_Cation_coupled_Chloride_cotransporte -0,29951 -0,17317 -0,03665 0,138573 0,32093 0,123998 -0,14893 -0,11892 0,028367 0,277588 -0,27954 1,083246 0,090769 0,071232 0,333313 0,466217 1,344056 1,385009 0,3372 0,522285 reactome_formation_of_the_beta_catenin_TCF_t -0,0302 -0,5341 -0,74208 -0,27445 -0,7715 -3,57949 4,048434 4,874556 2,825707 1,970397 1,341214 -0,05629 0,041293 -0,64686 1,196777 -9,17791 -6,33134 -5,56384 0,337435 0,522285 reactome_Oncogene_Induced_Senescence_Main_ 0,161415 0,21175 0,182155 2,04201 0,270879 0,623927 0,464838 0,278264 0,974556 2,338018 2,075413 2,347418 -0,29073 -0,44607 -0,19137 -0,24767 0,446785 0,165051 0,337515 0,522285 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(nu 0,059968 0,045056 0,034521 -0,42324 -0,22958 -0,04127 -0,47722 -0,28986 -0,56405 0,249604 -0,02826 -0,00454 0,021529 -0,03216 -0,32834 -1,92402 -1,31609 -1,16452 0,33805 0,522849 NCI_Osteopontin_mediated_events_Main_Pathw 0,019934 -0,38245 -0,50951 -1,12249 -1,8999 -2,17963 -2,49525 -1,88537 -3,37955 -0,23627 -1,34445 -1,29498 0,148943 0,29306 0,455405 -4,02688 -2,77336 -1,76075 0,338215 0,522849 reactome_Small_interfering_RNA_siRNA_biogene 0,089711 -0,09105 -0,06929 -1,35516 -0,72098 -1,23353 0,443704 0,502819 0,051851 -1,28498 -0,60893 -0,97673 0,464919 0,609322 0,46067 -1,30321 -1,19702 -1,05394 0,338518 0,523057 KEGG_Antigen_processing_and_presentation_Ma -0,52113 0,066436 0,517757 -3,19118 -4,17841 -1,66611 -1,41571 -2,12701 -0,26352 1,214032 1,8978 -1,20036 -0,87062 -1,95836 -0,25687 -3,63915 -4,34961 -3,56436 0,340287 0,525137 NCI_Signaling_events_mediated_by_the_Hedgeho -0,05191 -0,07167 -0,09445 -0,22695 0,338816 -0,03129 0,011959 -0,04633 0,181578 0,550348 0,260195 -0,36697 -0,0027 -0,25251 0,025064 0,171502 0,295807 0,204817 0,340238 0,525137 reactome_Coenzyme_A_biosynthesis_Main_Pathw0,035128 -0,19584 0,070542 0,359998 -0,4578 -0,42903 0,258008 0,297102 0,071125 0,151301 0,58026 -0,146 0,578062 0,229853 -0,09054 -0,5596 -0,70964 -1,11885 0,340434 0,525137 reactome_COPII_Coat_Protein_2_Mediated_Vesic 0,163766 -0,14483 0,028537 -1,25721 -0,92013 -1,01592 -1,45791 -1,20494 -1,79419 -1,11807 0,111489 -0,71365 -0,37815 0,013044 -0,13845 -3,65604 -2,542 -2,21844 0,340539 0,525137 NCI_PDGFR_alpha_signaling_Main_Pathway -0,24781 -0,33042 -0,59422 -2,31013 -2,51918 -2,12871 -3,44292 -3,29156 -3,85001 -0,25287 -1,61748 0,059633 0,044942 -0,3551 -0,10484 -2,09248 -0,77906 -0,18213 0,341213 0,525917 NCI_Alpha4_beta1_integrin_signaling_events_Ma -0,18556 -0,06833 -0,31574 -1,12089 -0,25154 -1,63187 -0,59354 -0,12391 -0,71635 1,10699 0,590582 1,208935 -0,8838 -0,24208 -0,55348 -2,74408 -1,31927 -1,06809 0,342581 0,526203 NCI_Arf6_trafficking_events_Pathway_(positive_r -0,05456 -0,17294 -0,12069 -0,35969 -0,86583 0,014415 -0,1399 -0,14751 -0,23059 -0,019 -0,24283 -0,17598 0,201963 0,086316 -0,00687 -0,79392 -0,71028 -0,87939 0,342397 0,526203 NCI_N_cadherin_signaling_events_Pathway_(apo -0,08134 -0,10135 -0,07301 -0,20876 0,437767 -0,28315 -0,5035 -0,59935 -0,7459 0,353488 0,941533 0,611949 0,120681 0,021884 0,188229 -1,96754 -1,29818 -0,96575 0,342278 0,526203 NCI_Rapid_glucocorticoid_signaling_Main_Pathwa -0,05386 -0,10083 -0,10924 -0,68993 -0,68647 -0,64078 -0,46755 -0,37695 -0,45661 -1,07799 -0,74642 -0,86927 0,240735 -0,18059 -0,02837 -0,7053 -0,6058 -0,53614 0,34201 0,526203 NCI_Rapid_glucocorticoid_signaling_Pathway_(glu -0,05386 -0,10083 -0,10924 -0,68993 -0,68647 -0,64078 -0,46755 -0,37695 -0,45661 -1,07799 -0,74642 -0,86927 0,240735 -0,18059 -0,02837 -0,7053 -0,6058 -0,53614 0,34201 0,526203 reactome_Phospholipase_C_mediated_cascade_M -0,65059 -0,32049 -0,10917 -0,70109 0,283311 -0,40205 -0,5255 -1,04985 0,721716 0,627359 -1,11924 -0,83509 -0,53303 -0,45569 -0,64468 0,606847 0,466698 -0,05885 0,342577 0,526203 urate_biosynthesisinosine_5-phosphate_degradat -0,03019 -0,09664 0,028366 -0,17 -0,29803 -1,12428 0,014865 -0,03895 -0,08245 0,859219 0,591905 0,984624 0,240434 0,189628 0,299502 -0,35426 -0,11342 -0,61348 0,342145 0,526203 molybdenum_cofactor_biosynthesis -0,0496 -0,06758 -0,10701 -0,0499 -0,03195 0,401575 0,550013 0,638302 0,280351 1,243953 0,509342 0,854982 0,326899 0,166161 0,216457 -1,41925 -1,31593 -1,01253 0,344152 0,528355 Akt_Signaling_Pathway_NF-kB_dependent_transc -0,03302 -0,20254 0,247423 -1,35409 0,196628 -1,41291 0,329634 0,166298 0,328264 0,269996 1,236658 -0,42996 0,569573 0,712994 0,260518 -0,27811 0,801986 0,797709 0,344829 0,52841 Cytoskeleton_Reorganization -1,09796 -1,05188 -1,02429 -4,74986 -4,8171 -3,22077 -6,80235 -6,96631 -7,12882 -0,13426 -4,17031 1,571226 0,992012 1,804627 1,547986 -9,7813 -7,59999 -5,40497 0,345036 0,52841 D-galactose_degradation_V_Leloir_pathway -0,02458 0,049945 0,162018 -0,36385 -0,31813 -0,38964 0,63887 0,736132 0,579298 -1,78644 -0,07548 -0,39246 -0,24464 -0,15924 0,056904 -0,80857 -0,58019 -0,56258 0,345018 0,52841 KEGG_Ovarian_steroidogenesis_Main_Pathway -0,53567 0,318087 0,103511 -0,55456 -2,37491 -2,02896 -1,37684 -1,49259 -0,65864 -1,99985 -1,45279 -0,21635 0,160605 1,344803 0,449967 1,993803 2,320753 1,938837 0,344504 0,52841 reactome_GABA_synthesis_release_reuptake_and -0,40992 -0,24621 -0,37497 -0,57565 -0,27782 -0,81216 -1,56501 -1,48924 -1,55032 -1,80508 -1,78826 -1,19824 0,126933 0,114507 0,265218 3,778929 3,72355 4,317915 0,344833 0,52841 KEGG_Histidine_metabolism_Main_Pathway -0,20112 -0,30848 -0,07071 -1,37998 -0,9162 -0,39947 -0,7388 -1,25804 -0,02215 -0,73366 -1,20493 0,30565 0,914021 0,307219 0,326118 1,341082 1,460546 2,227899 0,34667 0,530391 reactome_Nonsense_Mediated_Decay_NMD_enh 3,28858 0,616226 0,391713 -9,47393 -11,013 -13,267 8,279847 10,1308 4,622431 -5,2684 4,853203 2,563655 -1,16325 -0,86292 1,673355 -49,6248 -41,72 -35,9503 0,346611 0,530391 KEGG_Other_glycan_degradation_Main_Pathway 0,256543 0,312059 0,173775 -1,24633 -1,90341 -1,22981 -1,43942 -1,23252 -1,70569 0,536667 -1,24353 1,192965 -0,10111 -0,62093 0,326535 -1,23318 -1,47295 -1,4786 0,347531 0,531448 biocarta_rac1_cell_motility_signaling_Pathway_(a -0,33939 -0,1752 -0,03919 -0,6331 -0,59654 0,680961 -0,95116 -1,35862 -0,85329 -0,42968 0,210118 0,661934 0,227125 0,264735 0,221154 2,265884 0,26178 0,921033 0,347961 0,531844 NCI_Direct_p53_effectors_Main_Pathway -0,03012 0,034037 -0,04512 1,001422 0,667809 0,451775 -0,47746 -0,62758 -0,67041 -0,03254 0,349449 0,017327 -0,30784 -0,12502 -0,08899 0,136362 0,15042 -0,18415 0,348952 0,532575 NCI_Thromboxane_A2_receptor_signaling_Pathw -0,1987 -0,1149 0,0125 -0,64531 -1,06199 -1,06288 -0,78478 -1,09208 -0,38638 -1,38285 -0,59252 -0,61515 -0,81802 -0,46778 -0,07102 -1,14142 -0,40704 0,361873 0,348646 0,532575 p38_Signaling_Pathway_Translation 0,090264 -0,01773 -0,21349 -0,16676 -0,16886 -0,24512 -0,27554 -0,33953 -0,32978 0,067501 0,318777 -0,02055 0,10498 0,250595 0,306687 -0,65232 -0,17797 -0,49795 0,348914 0,532575 Akt_Signaling_Pathway_Induction_of_Chromatin_ -0,00345 -0,1567 0,301261 -1,19442 0,472632 -1,36479 0,168405 0,141973 0,343453 0,492288 1,186026 -0,56272 0,55514 0,563619 0,176526 -0,27849 0,908676 0,654251 0,349201 0,532694 Akt_Signaling_Pathway_Tumor_Supression -0,04761 -0,15395 0,270499 -1,33909 0,196047 -1,21965 -0,2066 -0,29841 0,032135 0,115633 1,093403 -0,3686 0,681252 0,601863 0,31431 0,021471 0,789592 0,804747 0,349798 0,533343 KEGG_African_trypanosomiasis_Main_Pathway 0,155723 -0,15776 0,071293 -0,19451 0,262671 -1,14384 -0,45874 -0,30617 -0,46178 -0,79917 -0,32813 -1,12396 0,069961 0,204415 0,686532 1,84251 2,064464 2,596421 0,350542 0,533758 NCI_amb2_Integrin_signaling_Pathway_(leukocyt -0,08811 -0,28561 -0,136 0,52422 -0,28689 -0,10154 -0,50785 -0,71657 0,054571 -0,76381 -0,14739 -0,42312 0,765538 0,209843 0,882268 1,081146 0,471662 0,84023 0,350288 0,533758 NCI_Regulation_of_Androgen_receptor_activity_M -0,15408 -0,07071 -0,26782 0,272874 -0,27632 0,693717 0,20908 0,359611 -0,42934 -0,98599 -0,59308 -0,63299 0,004003 0,328389 0,302909 0,007808 1,077244 1,165461 0,350584 0,533758 reactome_Synthesis_of_dolichyl_phosphate_man 0,005056 -0,05986 0,019309 0,216764 -0,27521 -0,448 0,2413 0,223865 0,185978 -0,29074 0,483729 -0,05158 0,095333 0,016334 0,081569 -0,96166 -0,61071 -0,54087 0,350891 0,533965 NCI_Alpha_synuclein_signaling_Pathway_(neuron -0,16891 -0,25262 -0,00289 0,03734 1,652863 0,47345 -2,48043 -2,66156 -2,22166 -0,70657 -0,39863 -0,09357 -0,16982 0,256148 0,602205 1,507669 0,008051 1,236863 0,351104 0,534027 biocarta_nerve_growth_factor_pathway_ngf__M -0,24667 -0,41835 -0,45923 -0,17201 -0,55323 -0,35946 -0,73208 -0,52456 -1,09745 -0,39738 0,544564 0,750872 0,145338 -0,43818 0,149273 -2,7012 -1,16072 -0,90248 0,351759 0,534763 creatine_biosynthesis 0,036106 0,009506 0,010513 0,209704 0,120941 0,1564 -1,02044 -0,94652 -1,0919 0,525804 0,059501 0,107248 -0,75023 -0,5527 -0,46938 -0,40028 -0,28292 -0,25345 0,351943 0,534782 KEGG_Epithelial_cell_signaling_in_Helicobacter_p 0,166388 -0,14257 0,021351 -0,85891 0,313806 -0,02388 -1,04953 -0,74595 -1,39776 0,538224 -1,01054 0,235538 0,547141 0,046459 0,570554 1,488873 1,038885 1,614434 0,352926 0,535688 KEGG_Lipoic_acid_metabolism_Main_Pathway 0,070546 0,115036 0,012247 0,187629 -0,51622 -0,2859 -0,33219 -0,25882 -0,57727 -0,95718 -0,569 -0,12589 -0,05793 -0,15186 -0,00978 -0,25057 -0,38427 -0,49049 0,353166 0,535688 NCI_Nectin_adhesion_Main_Pathway 0,002399 -0,05743 -0,01794 -1,31067 -0,62878 -1,67155 -1,70447 -1,53394 -2,10777 -0,194 0,16891 1,415812 0,411886 0,67229 0,920568 -4,17892 -3,19183 -3,18524 0,353227 0,535688 reactome_Scavenging_by_Class_F_Receptors_Ma -0,07343 -0,02467 0,058334 0,177919 0,576359 0,525846 0,010616 0,019808 0,099342 0,293249 0,383114 0,550155 -0,25981 0,189475 -0,27372 -1,02576 -0,48025 -0,17598 0,352818 0,535688 biocarta_rho_cell_motility_signaling_Pathway_(ac -0,26762 -0,16272 0,04273 -1,58534 -1,83829 -1,14049 -0,47441 -0,84442 -0,31575 -1,27462 0,559702 0,656258 0,58848 0,382397 0,71335 1,134626 0,026552 -0,31967 0,353872 0,536208 biocarta_the_igf_1_receptor_and_longevity_Path 0,061583 -0,13444 -0,04551 0,423515 0,016655 -0,25143 -1,35567 -1,28956 -1,59366 0,772586 -0,35144 0,157198 0,146737 0,031856 0,044622 -1,01645 -0,49161 0,046051 0,354235 0,536208 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(JN 0,004557 0,081079 0,097354 -0,34112 0,004729 0,12651 -0,55905 -0,40096 -0,56352 0,149396 0,175164 -0,03914 -0,08704 -0,06836 -0,29356 -1,22452 -1,20357 -0,90018 0,354431 0,536208 NCI_Regulation_of_nuclear_SMAD2_3_signaling_ -0,70734 -0,54629 -0,43968 0,211802 -0,83553 0,07964 -3,44377 -4,02684 -3,07501 -1,41229 -1,80572 -1,29952 -0,3327 -0,37653 -0,01516 5,294803 3,346512 3,548116 0,354389 0,536208 reactome_Rap1_signalling_Main_Pathway -0,1156 -0,08173 -0,09725 -0,48092 -0,18989 -1,50928 -0,43325 -0,42145 -0,66268 -2,63599 -1,24341 -0,48426 -0,2593 -0,09383 -0,22354 -1,48873 -0,95759 -0,15865 0,354357 0,536208 biocarta_aspirin_blocks_signaling_pathway_involv 0,037534 -0,32408 -0,3124 -1,10808 -1,38875 -1,83243 -0,32308 -0,09746 -0,42353 -1,1291 0,109929 0,092987 0,526618 0,335175 0,885493 -2,68941 -3,08976 -2,01961 0,355234 0,536381 ILK_Signaling_Pathway_Cell_Cycle_Proliferation -0,53653 -0,50242 -0,2547 -0,47365 0,002531 -0,14601 -3,63616 -3,07764 -3,25981 2,54225 0,24139 3,382412 0,285167 0,455274 1,113465 -4,01753 -3,53579 -3,33607 0,354977 0,536381 ILK_Signaling_Pathway_G2_Phase_Arrest -0,53653 -0,50242 -0,2547 -0,47365 0,002531 -0,14601 -3,63616 -3,07764 -3,25981 2,54225 0,24139 3,382412 0,285167 0,455274 1,113465 -4,01753 -3,53579 -3,33607 0,354977 0,536381 mitochondrial_L-carnitine_shuttle -0,0116 -0,05454 -0,01501 -0,48021 -0,90115 -0,55055 -0,60934 -0,56014 -0,57438 0,063141 0,098131 -0,03292 0,350558 -0,04806 -0,24403 -0,27569 -0,51836 -0,35519 0,355212 0,536381 Akt_Signaling_Pathway_Enhancement_of_Breast_ 0,004984 -0,14213 0,29804 -1,24253 0,341495 -1,33909 0,163357 0,114177 0,27597 0,289644 1,303049 -0,28904 0,671756 0,574602 0,274695 -0,22217 0,595212 0,759519 0,355938 0,537005 KEGG_Serotonergic_synapse_Main_Pathway 0,148482 0,336506 0,056955 3,381722 3,042291 1,896393 1,558087 0,674015 2,472084 -2,06921 1,361835 1,60008 -0,16668 -0,01585 -0,04066 1,357533 -0,37662 2,665174 0,356308 0,537005 NCI_CD40_CD40L_signaling_Main_Pathway 0,185324 0,090654 -0,20854 -1,82041 -1,61855 -0,55564 -1,19298 -0,52089 -1,88755 -0,54707 0,413729 0,710943 1,125259 0,646113 1,238881 -3,36603 -2,84363 -2,49099 0,356429 0,537005 reactome_p75NTR_recruits_signalling_complexes 0,159003 -0,13095 -0,00432 -0,55958 -0,33662 -1,05722 -1,42145 -1,39978 -1,69825 0,90524 0,30254 0,594766 0,648071 -0,18105 0,240995 -3,71571 -3,19916 -2,26744 0,356483 0,537005 thiosulfate_disproportionation_III_rhodanese -0,00876 -0,0381 0,020979 -0,1981 0,195713 0,20233 0,138417 0,130078 0,128377 0,540588 0,079711 0,604878 -0,05756 -0,0554 -0,152 -0,00626 -0,17076 -0,1196 0,356509 0,537005 EGF_Pathway -0,96763 -1,05956 -1,17006 -4,22271 -1,96404 -2,42503 -4,77341 -3,54351 -6,86154 1,988643 0,043507 -1,60861 -0,03625 0,733774 1,237301 -10,7736 -7,95349 -2,30313 0,357233 0,537835 KEGG_Taste_transduction_Main_Pathway -0,36361 0,049571 -0,17249 -0,56901 -0,1554 -0,718 -1,4047 -1,46259 -1,07324 -1,80974 -0,40492 1,022725 -0,51637 0,238744 -0,10304 0,838247 0,097134 0,794071 0,358532 0,539161 protein_citrullination -0,06173 0,015652 0,130054 0,840189 0,911486 0,42612 -0,11721 -0,24163 0,366732 -0,42987 -0,0297 -0,02233 0,125929 0,17676 0,105043 0,836967 0,870673 0,725347 0,358328 0,539161 reactome_Vitamins_B6_activation_to_pyridoxal_p -0,08548 -0,07695 -0,02381 -0,06986 0,623865 0,010651 0,184508 0,107142 0,201704 0,592315 0,207323 0,341195 -0,03321 0,06646 -0,18758 0,549469 -0,00887 0,392697 0,358633 0,539161 reactome_Beta_oxidation_of_pristanoyl_CoA_Ma 0,172807 0,03039 -0,02517 -1,00537 -0,4768 0,239487 -0,52196 -0,35175 -0,73647 -0,69721 -0,24147 0,451387 0,470064 0,435965 0,785511 -0,88525 -0,62013 -0,24969 0,359601 0,540355 biocarta_role_of_brca1_brca2_and_atr_in_cancer 0,078466 -0,10677 -0,10325 0,3004 0,408777 0,157267 -0,45558 -0,12306 -0,77414 0,383962 0,975432 0,585976 -0,10545 -0,17584 -0,29634 -2,00392 -1,31045 -1,03811 0,35997 0,54051 NCI_IL12_mediated_signaling_events_Main_Pathw0,066231 0,086905 0,310966 -3,14789 -0,90846 -1,99025 0,285254 -0,54939 0,216524 0,078287 -0,45136 0,244093 0,877798 0,417839 1,530005 0,670364 0,096331 0,79488 0,360051 0,54051 reactome_TRAF6_Mediated_Induction_of_proinf 0,227171 0,054573 0,064455 -0,32753 -0,39251 -0,56984 0,417012 0,428903 0,233663 -0,14463 0,586906 0,403653 0,094986 0,07073 0,101822 -2,52008 -2,00645 -1,75506 0,361322 0,542157 NCI_E_cadherin_signaling_in_the_nascent_adher 0,025669 0,015452 0,03647 -0,39819 -0,39114 -1,08201 -0,86732 -0,7489 -1,18154 -0,19011 1,058433 0,321951 -0,43016 -0,1018 -0,16561 -4,47849 -3,48119 -3,10434 0,361622 0,542346 EGF_Pathway_IP3_Signaling -0,00527 -0,01366 -0,06179 -0,2401 -0,13845 -0,86375 0,946791 1,021281 0,726306 -0,37174 -0,20169 -0,76243 0,093014 -0,23202 0,146893 -0,81337 -0,72647 -0,47589 0,362057 0,542737 NCI_Atypical_NF_kappaB_Pathway_(Pathway_deg -0,03545 -0,08537 -0,10669 -0,82582 0,366664 -0,3955 -0,47219 -0,35408 -0,66799 -0,32837 -1,22147 0,717266 0,361661 -0,07746 0,26214 -0,43593 -0,78114 -0,45643 0,362345 0,542907 KEGG_Long_term_potentiation_Main_Pathway 0,289962 -0,2282 -0,05761 1,578254 2,152269 -0,3209 -5,26475 -4,71199 -5,90855 -4,1799 0,966364 -0,80885 -0,97716 -0,52622 0,285079 -1,85153 0,494099 2,011125 0,362999 0,543357 NCI_Urokinase_type_plasminogen_activator_uPA -0,04411 -0,04404 -0,13763 0,103906 -0,36996 0,528429 -1,20655 -1,2212 -0,95218 -1,06457 -0,51621 -0,83755 -0,01451 0,060566 0,12836 -0,05736 0,671346 0,709966 0,36316 0,543357 reactome_Arachidonate_production_from_DAG_ -0,08295 -0,12192 -0,0472 -0,05813 -0,25716 -0,63014 -0,68706 -0,64933 -0,80182 -0,17912 0,127505 -0,30482 -0,03808 0,143404 0,265942 0,487594 0,339465 0,270291 0,363168 0,543357 NCI_E_cadherin_signaling_in_the_nascent_adher -0,06351 -0,00736 -0,02201 -0,47816 0,597167 -0,52001 0,568318 0,673637 0,613297 0,790224 0,307412 -0,07981 -0,80691 -0,45332 -0,41448 -1,07576 -0,68213 -0,02874 0,364876 0,54565 NCI_mTOR_signaling_Pathway_(regulation_of_act 0,071162 -0,02004 -0,05338 -0,3218 -0,45646 -0,55963 -0,88198 -0,9154 -1,03198 -0,11091 -0,21356 -0,64962 0,241948 0,66361 0,662011 -0,41281 -0,27586 -0,09421 0,366148 0,547027 NCI_mTOR_signaling_Pathway_(regulation_of_pr 0,071162 -0,02004 -0,05338 -0,3218 -0,45646 -0,55963 -0,88198 -0,9154 -1,03198 -0,11091 -0,21356 -0,64962 0,241948 0,66361 0,662011 -0,41281 -0,27586 -0,09421 0,366148 0,547027 KEGG_Regulation_of_autophagy_Main_Pathway 0,382555 0,11396 -0,07304 0,288706 -0,09113 -0,15957 -1,78758 -1,64699 -2,28654 1,179024 1,916474 0,868958 0,046632 0,185986 0,331402 -4,08133 -3,04364 -2,35962 0,366735 0,547642 NCI_Regulation_of_Androgen_receptor_activity_P 0,048728 0,034852 0,004348 0,234694 -0,02089 0,173526 0,095353 0,057553 0,12989 0,459602 0,084635 0,130126 0,10557 0,030892 -0,01745 0,137486 0,233591 0,155086 0,367506 0,54853 guanosine_ribonucleotides_ide_novoi_biosynthes 0,054482 -0,04583 -0,06683 -0,45387 -0,58294 -0,52633 -0,2038 -0,11292 -0,62458 1,734637 2,288386 1,588975 0,69554 0,721369 0,92129 -4,68782 -3,99329 -3,66203 0,368568 0,549851 KEGG_Pantothenate_and_CoA_biosynthesis_Main 0,141919 -0,20112 0,454024 -0,43969 -2,01833 -2,93049 0,59612 0,428976 0,585322 -0,54998 0,322967 0,171228 0,312416 -0,17509 -0,79025 -0,81521 -1,84507 -1,79398 0,369375 0,550791 Ras_Pathway_RhoA_Pathway 0,087038 -0,1039 -0,20429 0,485378 0,375547 0,073823 -0,21905 -0,22909 -0,68311 0,979464 0,457591 1,257151 -0,06699 -0,00796 -0,27528 -2,00171 -1,62691 -1,35288 0,371486 0,553674 phosphatidylcholine_biosynthesis 0,098883 -0,01299 0,004056 -0,61595 -0,18682 0,110058 -0,2477 -0,14976 -0,50837 -1,26165 0,182244 0,412478 -0,58775 -0,42336 -0,33265 -2,74447 -1,56307 -1,34031 0,371727 0,553721 reactome_Class_A_1_Rhodopsin_like_receptors__ -0,7749 -0,04958 -0,13344 0,433406 -1,32948 -1,00626 0,216069 -0,34983 1,19692 1,860441 -1,54138 -0,0659 0,858395 1,023105 0,883569 3,521936 1,924725 2,41265 0,371873 0,553721 biocarta_growth_hormone_signaling_Main_Pathw -0,31174 -0,4364 -0,23098 -0,99961 -1,28066 -2,62298 -0,27997 -0,376 -0,55272 1,716266 0,527038 -0,23148 0,778396 0,231411 1,06362 -0,99873 0,195857 0,983975 0,372894 0,554494 reactome_Toxicity_of_botulinum_toxin_type_D_B -0,07001 0,204879 0,10533 0,392064 0,117744 -0,64227 -0,0435 -0,06565 -0,14503 -0,916 -0,99086 -0,86704 0,773904 0,517845 0,541304 0,464688 1,008819 0,897481 0,372926 0,554494 reactome_Toxicity_of_botulinum_toxin_type_F_B -0,07001 0,204879 0,10533 0,392064 0,117744 -0,64227 -0,0435 -0,06565 -0,14503 -0,916 -0,99086 -0,86704 0,773904 0,517845 0,541304 0,464688 1,008819 0,897481 0,372926 0,554494 reactome_Hormone_sensitive_lipase_HSL_mediat -0,32682 -0,33291 -0,13322 -0,19458 -0,44876 -1,37513 -2,74325 -2,49328 -2,8543 0,590901 -0,78917 0,099721 -0,53644 -0,64801 0,02959 -0,98075 -0,8711 0,184327 0,373667 0,55533 KEGG_Valine_leucine_and_isoleucine_degradatio 0,853746 0,086041 0,485523 -1,05522 -0,5393 -3,1715 3,559683 4,298119 1,189346 2,254783 4,36531 3,452267 0,395002 0,390913 0,468396 -15,6205 -12,3766 -10,7123 0,375152 0,557214 Regulation_of_Cell_Migration_by_Platelet-derived -0,10906 -0,42335 -0,28577 -1,4228 -1,27626 -1,99549 -2,24757 -1,80401 -2,67922 -0,07065 -0,95648 0,438389 -0,25688 -0,13896 0,333458 -1,70007 -0,41662 -0,05555 0,375292 0,557214 reactome_Synthesis_of_PG_Main_Pathway 0,071508 -0,07449 -0,05941 -0,03804 -0,29903 -1,06878 -0,48146 -0,73311 -0,67362 0,649916 -0,41308 0,332368 0,60332 0,2265 0,475567 0,568077 0,516807 0,629729 0,375776 0,557667 KEGG_Bacterial_invasion_of_epithelial_cells_Main -0,50047 -0,8897 -1,27065 -4,93431 -4,45532 -4,45836 -3,49142 -3,15652 -4,2622 -2,12914 -1,96207 0,508228 0,40828 -0,2078 1,71173 -10,8954 -9,23869 -6,68209 0,376051 0,55781 glutamate_dependent_acid_resistance -0,00238 0,039714 -0,05851 -0,56533 -0,08009 0,169032 -0,36702 -0,30397 -0,25168 0,342721 0,578902 -0,19772 0,114373 -0,01992 0,136747 -0,26121 0,301389 0,077607 0,378999 0,561393 NCI_IL23_mediated_signaling_events_Main_Pathw 0,05913 -0,08591 -0,08355 -2,22229 -0,4208 -1,24386 -0,70772 -0,44878 -0,71993 -0,44879 -1,29303 1,456747 -0,31048 -0,67694 0,451895 -0,59117 -0,65795 -1,17244 0,379008 0,561393 Role_of_Cholinergic_Receptors_in_Migration_of_ 0,123229 0,123559 -0,03814 -0,42613 0,356202 -0,12844 -0,062 -0,00319 -0,21161 -0,10325 -0,3276 -0,67856 0,024346 0,198828 -0,10775 0,646847 1,202015 0,779085 0,378818 0,561393 KEGG_Aminoacyl_tRNA_biosynthesis_Main_Pathw0,155281 -0,05468 0,100888 -0,02643 -0,16003 -0,7618 0,037278 0,117797 -0,27445 0,708628 -0,21181 0,58101 0,025578 0,034241 0,061002 -1,95651 -1,93753 -1,84915 0,37949 0,56184 NCI_N_cadherin_signaling_events_Pathway_(myo -0,21493 -0,03502 0,00399 0,044239 0,935038 -0,05972 -1,14444 -1,33751 -1,04583 0,895897 1,374661 0,368202 -0,00527 -0,20118 -0,07645 -1,98805 -1,46139 -1,39442 0,379794 0,562023 NCI_p73_transcription_factor_network_Pathway_ -0,18742 -0,18854 -0,42417 -0,78681 -0,58868 0,31699 -1,9434 -1,44957 -2,39852 -0,11415 -1,55219 -0,01034 -0,14634 -0,2133 0,040604 -0,96827 -0,19447 -0,34911 0,380222 0,56239 KEGG_Arrhythmogenic_right_ventricular_cardiom -0,27193 -0,24255 -0,13254 -0,33666 -0,07143 -0,70727 -0,29851 -0,23728 -0,26743 0,918606 1,059231 0,69207 0,233588 0,367603 0,795888 -2,0577 -2,23208 -1,06867 0,380882 0,562718 reactome_MEK_activation_Main_Pathway -0,0686 -0,15517 -0,17912 -0,20362 -0,22219 -0,61659 -0,70061 -0,54597 -0,95442 -0,98133 0,471339 0,311352 -0,39901 -0,36056 -0,18291 -1,85202 -1,65536 -1,32652 0,380987 0,562718 reactome_RAF_phosphorylates_MEK_Main_Pathw -0,0686 -0,15517 -0,17912 -0,20362 -0,22219 -0,61659 -0,70061 -0,54597 -0,95442 -0,98133 0,471339 0,311352 -0,39901 -0,36056 -0,18291 -1,85202 -1,65536 -1,32652 0,380987 0,562718 KEGG_Phototransduction_Main_Pathway 0,09359 0,126099 -0,10776 0,719306 0,829519 0,227935 0,55792 0,426897 0,866791 1,140971 0,651854 0,168411 0,130991 0,446249 0,365373 0,300731 -1,54944 0,93866 0,381333 0,562963 reactome_Synthesis_of_pyrophosphates_in_the_ -0,18883 -0,06698 -0,05184 -0,51797 0,526159 -0,13473 -1,12233 -1,26787 -1,437 1,150576 -0,58927 -0,13943 0,076245 0,526997 0,414183 -0,06997 -0,65325 -0,03768 0,381705 0,563246 KEGG_Vibrio_cholerae_infection_Main_Pathway -0,36643 -0,16446 -0,22314 -1,14974 -1,55911 -1,16626 -0,25876 0,027875 -0,12463 0,051012 0,100106 0,846698 0,075367 0,134454 0,15 -1,08912 -0,76337 -0,57661 0,38198 0,563385 NCI_Regulation_of_CDC42_activity_Main_Pathwa -0,05181 -0,42491 -0,47546 -2,33711 -3,31534 -2,60448 -0,79366 -0,23876 -1,39321 -0,57599 0,602443 -0,16929 -0,42438 0,394082 0,542211 -2,67419 -1,60661 0,057882 0,383168 0,564334 NCI_Thromboxane_A2_receptor_signaling_Main_ -0,38762 -0,36974 -0,05317 -1,78066 -2,25649 -1,56179 0,077305 -0,44272 0,464392 -2,32149 -1,00904 -1,20838 -0,91215 -0,91151 -0,15046 -1,98277 -0,76905 0,130862 0,382992 0,564334 reactome_FGFR1c_ligand_binding_and_activation -0,24717 -0,28073 -0,06736 -0,62833 -0,53181 -1,02246 -0,7096 -0,84529 -0,24411 -0,11039 -0,4454 0,153064 -0,1361 -0,12733 -0,15344 -0,46126 -0,25919 -0,75839 0,382953 0,564334 NCI_CDC42_signaling_events_Pathway_(regulatio -0,23807 -0,12068 -0,29413 -0,24507 -0,38039 -0,3032 -0,98531 -0,82503 -0,93904 0,19517 0,1446 -0,30513 0,056113 0,125653 -0,06955 0,167461 0,190852 -0,06755 0,383373 0,56437 ATM_Pathway_S-phase_progression 0,100775 0,057317 0,027774 0,763 0,235135 0,832794 0,266214 0,37472 -0,02276 0,087915 -0,21224 -0,35883 -0,0825 -0,19897 -0,22873 -0,43402 0,321032 0,554954 0,383808 0,564743 KEGG_Dilated_cardiomyopathy_Main_Pathway -0,00564 -0,26446 0,044368 -0,87873 -0,95245 0,88317 -0,76364 -1,2665 -0,3621 0,338963 -0,02969 -1,7674 0,05754 0,507206 0,165462 2,123521 1,646874 1,679392 0,384172 0,564745 KEGG_Hypertrophic_cardiomyopathy_HCM__Mai -0,00564 -0,26446 0,044368 -0,87873 -0,95245 0,88317 -0,76364 -1,2665 -0,3621 0,338963 -0,02969 -1,7674 0,05754 0,507206 0,165462 2,123521 1,646874 1,679392 0,384172 0,564745 NCI_a6b1_and_a6b4_Integrin_signaling_Pathway_ 0,012874 0,035557 0,04616 -0,15647 -0,19008 -0,61081 -0,72137 -0,69203 -0,80881 -0,41724 -0,00643 -0,15529 -0,10923 -0,0237 -0,03207 -1,21964 -0,87878 -0,53216 0,384362 0,564758 L-kynurenine_degradation -0,11579 0,187798 0,182529 -0,69533 -0,48863 -0,02275 -0,30018 -0,66246 -0,16537 -1,61144 -0,85492 -1,64044 0,010379 -0,95 -0,91029 0,758084 1,515738 0,153311 0,386165 0,567074 NCI_Class_I_PI3K_signaling_events_mediated_by_ 0,01545 -0,00502 -0,19519 0,070059 -0,47202 -0,03337 -0,45041 -0,38266 -0,56988 0,212016 0,374681 0,097918 -0,15556 -0,25635 -0,40917 -0,4817 -0,62983 -0,16506 0,386302 0,567074 reactome_GTP_hydrolysis_and_joining_of_the_60 3,347792 1,355295 0,816484 -8,88391 -11,3327 -13,1635 8,22366 9,915061 4,42298 -4,39742 7,461781 4,96995 -2,29631 -1,63653 1,052358 -54,695 -45,003 -38,2095 0,386987 0,567812 biocarta_skeletal_muscle_hypertrophy_is_regulat 0,210451 0,159555 0,070731 -0,08929 -0,26879 -0,713 0,764382 0,886838 0,467137 0,243493 -0,0428 0,174823 -0,45254 -0,3861 0,120476 -2,88542 -2,15102 -2,06488 0,387468 0,567982 TSPANs_Influence_on_Integrin-based_Cell_Migra -0,07261 -0,25771 -0,51288 -1,48814 -4,47459 -1,83456 -7,28826 -6,7699 -8,65574 -2,5969 0,344647 -0,61745 -0,77149 -1,39511 -0,71175 -9,71958 -7,65998 -6,20992 0,387368 0,567982 biocarta_cell_cycle_g2_m_checkpoint_Pathway_( 0,11739 0,007474 0,011975 0,416058 0,624927 0,246951 0,260642 0,479998 -0,05707 0,56299 0,635933 0,43159 -0,19765 -0,20441 -0,22649 -1,37453 -0,94019 -0,72185 0,388484 0,569204 biocarta_role_of_erbb2_in_signal_transduction_a -0,06213 -0,34175 -0,54939 -2,28448 -1,4225 -2,36308 -0,83132 -0,7616 -1,45537 0,145579 1,508244 1,291373 0,168773 -0,33249 0,437139 -2,7232 -1,86844 -0,6643 0,388697 0,569248 reactome_Pyrimidine_catabolism_Main_Pathway -0,42781 0,086071 -0,03041 -0,07756 0,809657 -1,22967 -0,95543 -1,05209 -0,44476 0,5113 -0,37311 0,014105 -0,62101 -0,44701 -0,00703 0,715634 0,380962 -0,62889 0,388975 0,569388 Junctional_Cell_Adhesion_in_Endothelium -0,4014 -0,25479 -0,12888 -0,7305 -1,04375 -2,27604 -0,83043 -1,31737 -0,95165 1,379098 0,260652 -0,13443 1,838391 0,850191 2,343593 -3,27793 -1,60058 -1,36539 0,389635 0,570085 IL-10_Pathway_IL-10_Responsive_Genes_Transcri -0,12692 -0,35259 -0,33213 -0,12913 -0,30758 -0,46915 1,219225 1,893608 0,893645 2,784676 0,883027 1,866511 0,769412 0,502844 1,112876 -4,13188 -2,29079 -2,32895 0,390965 0,571496 IL-10_Pathway_Inflammatory_Cytokine_Genes_Ex -0,12692 -0,35259 -0,33213 -0,12913 -0,30758 -0,46915 1,219225 1,893608 0,893645 2,784676 0,883027 1,866511 0,769412 0,502844 1,112876 -4,13188 -2,29079 -2,32895 0,390965 0,571496 reactome_Synthesis_of_5_eicosatetraenoic_acids -0,10482 -0,06624 0,015334 0,336759 -0,80896 0,487633 -0,29925 -0,39287 0,032762 0,393108 0,803672 0,724844 0,096108 -0,26291 0,035329 0,0677 0,322897 -0,44618 0,391253 0,571648 reactome_eNOS_activation_Main_Pathway 0,124318 -0,07619 -0,01586 -0,90709 -0,44029 -0,35692 -1,05923 -1,0589 -1,4723 0,157357 0,176904 0,275874 -0,50263 -0,24692 -0,64497 -1,38962 -1,20687 -0,80165 0,39155 0,571814 BRCA1_Pathway_Cell_Cycle_Arrest_DNA_Repair_ 0,108332 0,021866 -0,032 0,671595 0,317872 0,006742 0,33726 0,622465 -0,03104 1,027442 0,362946 0,271397 0,02627 -0,00524 0,063816 -0,92014 -0,26329 -0,74617 0,391823 0,571944 reactome_Downregulation_of_ERBB2_ERBB3_sig 0,26524 -0,12807 -0,05724 -0,33932 0,483981 -0,70329 -0,1382 -0,07642 -0,78841 0,491525 1,429025 0,963202 -0,0531 0,077172 0,010776 -3,98899 -2,893 -2,05408 0,393305 0,573839 Akt_Signaling_Pathway_Acetylation_of_proteins -0,02743 -0,18176 0,243291 -1,16131 0,370528 -1,27001 0,061919 0,02362 0,138129 0,379252 1,338398 -0,07718 0,791479 0,614017 0,392781 -0,18282 0,552932 0,955832 0,393952 0,574245 KEGG_Non_small_cell_lung_cancer_Main_Pathwa -0,55018 -0,73063 -0,80578 -0,97047 0,178006 -1,80212 -1,08854 -0,49092 -2,03753 -0,09708 0,322567 1,087463 0,186088 -0,34071 0,974932 -4,79086 -1,8279 -0,70851 0,393863 0,574245 dermatan_sulfate_degradation_metazoa 0,049434 -2,07E-05 0,048733 -1,48106 -0,84799 -0,94445 -0,53658 -0,44702 -0,52181 1,631018 -0,3023 0,599696 -0,14254 -0,212 0,192134 -1,28543 -1,09456 -1,50358 0,395251 0,575355 NCI_PAR1_mediated_thrombin_signaling_events_ -0,09624 -0,37217 -0,17185 0,678671 0,889144 -0,38883 -0,91155 -0,70001 -0,81286 -0,16568 -1,2855 -1,64507 -0,12317 -0,10736 0,426716 0,503824 0,780169 1,473308 0,394928 0,575355 reactome_Laminin_interactions_Main_Pathway -0,16782 -0,171 -0,11618 -0,67788 -1,84659 -1,09893 -4,40258 -4,64322 -4,75404 2,3122 1,47713 0,218339 -0,42321 -0,23054 -0,64313 -1,96635 -2,22986 -2,11989 0,395268 0,575355 reactome_Chondroitin_sulfate_biosynthesis_Main -0,17896 -0,39789 -0,28844 -0,20271 -0,22904 -0,393 0,030101 -0,25665 0,120877 -0,39261 -1,66069 0,360264 0,105319 0,576072 1,691165 3,381763 4,214223 3,50667 0,395787 0,575654 reactome_Lysine_catabolism_Main_Pathway 0,175685 0,057265 0,079488 -0,61755 -0,91505 -0,95368 1,030297 1,280331 0,591674 -0,04771 1,14968 1,109591 -0,2602 0,123946 -0,2155 -1,821 -1,33497 -0,64888 0,395843 0,575654 KEGG_Phenylalanine_tyrosine_and_tryptophan_b -0,07712 0,046873 0,062889 0,192673 -0,63197 -0,28188 0,254803 0,310668 0,524261 0,322431 0,136537 1,042131 0,005649 0,254439 0,0476 -0,0388 -0,24427 -0,35682 0,397479 0,576886 reactome_binding_of_TCF_LEF_CTNNB1_to_targe -0,17289 -0,1844 -0,127 -0,27011 -0,34905 -0,74234 -0,33521 -0,20277 -0,35703 0,649005 0,931656 0,847155 0,136458 0,373346 0,783955 -2,16146 -2,35998 -1,23581 0,397368 0,576886 reactome_Formation_of_the_ternary_complex_a 1,352488 0,684484 0,291812 -4,75616 -4,83099 -5,49404 3,981531 4,831749 2,387973 -2,53652 3,400178 2,678264 -1,14494 -1,74469 0,036927 -24,9793 -21,397 -17,8987 0,397043 0,576886 reactome_Release_of_eIF4E_Main_Pathway 0,085117 0,109203 0,022044 -0,26623 0,202968 -0,47943 0,345854 0,387841 0,057356 0,025845 -0,52043 -0,67478 0,479987 -0,13409 0,204994 -0,60619 -0,19614 0,286827 0,397616 0,576886 reactome_Scavenging_by_Class_A_Receptors_Ma -0,20647 0,016766 0,230752 -0,16279 0,601149 0,409396 -0,20621 -0,49239 0,288508 0,567284 -0,16684 0,627199 0,058045 0,244281 -0,14736 1,103916 0,618986 0,21479 0,397343 0,576886 biocarta_insulin_signaling_Main_Pathway -0,0023 -0,25644 -0,21634 -0,24811 -0,2355 -0,97327 -1,43196 -1,50636 -1,72861 1,026325 0,449783 -0,396 0,416118 0,264229 0,461348 -2,27608 -1,00835 -0,81353 0,398605 0,577514 KEGG_Allograft_rejection_Main_Pathway -0,00014 0,06814 -0,05993 -0,12348 0,106456 0,059927 0,021723 0,089755 0,107456 -0,04193 -0,27879 0,067829 -0,16284 0,076734 -0,05821 -0,47756 -0,27573 0,183761 0,398597 0,577514 reactome_Ribosomal_scanning_and_start_codon_ 1,693714 0,990572 0,593714 -4,30094 -4,93888 -5,68948 3,648939 4,653776 1,610179 -1,69892 4,302291 3,006627 -0,886 -1,85892 0,228382 -27,754 -23,0958 -18,8006 0,398336 0,577514 KEGG_Sulfur_relay_system_Main_Pathway -0,0825 -0,15511 -0,12838 -0,21264 0,680441 0,523628 0,403437 0,38671 0,192887 2,349812 0,496907 0,397337 0,27556 0,129042 0,044721 -1,19858 -1,5335 -1,28667 0,400718 0,580305 reactome_AKT_phosphorylates_targets_in_the_n -0,08948 -0,18509 -0,01597 0,239168 0,457641 0,20137 0,284331 0,330652 0,137567 -0,5668 0,109258 -0,13356 0,231981 -0,14737 0,094021 0,193385 0,547282 0,60792 0,40096 0,580387 KEGG_Osteoclast_differentiation_Main_Pathway -2,33664 -0,48855 -0,64763 0,825069 -1,18444 2,050523 -2,44489 -3,95254 -0,60984 -2,05592 -0,60598 0,471163 -0,09442 -0,6704 1,216978 6,073547 6,214303 7,466999 0,402865 0,580887 NCI_Arf6_downstream_Pathway_(liver_developm 0,006941 -0,05848 -0,0376 -0,07168 -0,39179 0,073645 -0,03055 -0,04361 -0,05806 -0,16693 -0,25344 -0,28603 0,151555 0,077987 0,016693 0,027073 -0,03148 -0,11837 0,402985 0,580887 NCI_Arf6_downstream_Pathway_(myoblast_fusio 0,006941 -0,05848 -0,0376 -0,07168 -0,39179 0,073645 -0,03055 -0,04361 -0,05806 -0,16693 -0,25344 -0,28603 0,151555 0,077987 0,016693 0,027073 -0,03148 -0,11837 0,402985 0,580887 NCI_Arf6_downstream_Pathway_(regulation_of_e 0,006941 -0,05848 -0,0376 -0,07168 -0,39179 0,073645 -0,03055 -0,04361 -0,05806 -0,16693 -0,25344 -0,28603 0,151555 0,077987 0,016693 0,027073 -0,03148 -0,11837 0,402985 0,580887 NCI_Arf6_downstream_Pathway_(substrate_adhe 0,006941 -0,05848 -0,0376 -0,07168 -0,39179 0,073645 -0,03055 -0,04361 -0,05806 -0,16693 -0,25344 -0,28603 0,151555 0,077987 0,016693 0,027073 -0,03148 -0,11837 0,402985 0,580887 NCI_Arf6_trafficking_events_Pathway_(clathrin_in 0,013882 -0,11696 -0,0752 -0,14336 -0,78358 0,14729 -0,0611 -0,08722 -0,11611 -0,33387 -0,50688 -0,57205 0,303111 0,155974 0,033386 0,054147 -0,06295 -0,23674 0,402985 0,580887 NCI_Arf6_trafficking_events_Pathway_(positive_r 0,013882 -0,11696 -0,0752 -0,14336 -0,78358 0,14729 -0,0611 -0,08722 -0,11611 -0,33387 -0,50688 -0,57205 0,303111 0,155974 0,033386 0,054147 -0,06295 -0,23674 0,402985 0,580887 NCI_Arf6_trafficking_events_Pathway_(receptor_ 0,013882 -0,11696 -0,0752 -0,14336 -0,78358 0,14729 -0,0611 -0,08722 -0,11611 -0,33387 -0,50688 -0,57205 0,303111 0,155974 0,033386 0,054147 -0,06295 -0,23674 0,402985 0,580887 reactome_Initiation_of_Nuclear_Envelope_Reform -0,02834 0,003157 -0,00038 -1,0898 -0,36716 -0,16871 0,082654 0,380365 -0,15116 -0,35163 0,925366 -1,05421 -0,05044 -0,49416 0,040853 -2,42011 -1,90089 -1,48102 0,402291 0,580887 reactome_The_AIM2_inflammasome_Main_Pathw -0,04249 -0,04058 -0,21416 0,057578 -0,95042 -0,88918 0,729455 0,694489 0,618259 -0,11755 -0,18024 -0,62912 -0,32497 -0,01399 0,463581 0,679842 0,075343 0,014484 0,403397 0,581212 KEGG_VEGF_signaling_Main_Pathway -0,30689 -0,61052 -0,66077 -1,44199 -1,90929 -2,24365 -1,44233 -1,16027 -1,27909 -0,89575 0,837894 1,026645 -0,59618 -0,82956 0,371559 -3,64566 -1,00278 -0,08634 0,403778 0,581493 biocarta_endocytotic_role_of_ndk_phosphins_an 0,129653 -0,12821 0,161837 1,439735 0,665773 1,139717 -2,15255 -1,83863 -2,36119 -0,19945 1,150975 -0,28964 -0,40935 -0,71001 -0,49124 -0,84774 -0,30615 -0,56997 0,405235 0,582819 glucocorticoid_biosynthesis -0,19976 -0,3001 -0,01891 0,492777 -0,09597 0,198431 0,123972 -0,15845 0,478501 -0,00549 -0,39181 -0,32353 -0,14029 -0,30454 -0,12051 1,384252 1,194216 0,708986 0,404921 0,582819 NCI_CXCR4_mediated_signaling_events_Pathway_ -0,26865 -0,43559 -0,16965 -1,20699 0,261164 -1,09788 -0,68615 -0,94174 -0,67122 -0,94903 -1,0902 -0,92274 -0,36039 -0,15607 0,023678 0,656986 1,294682 1,073914 0,40526 0,582819 biocarta_endocytotic_role_of_ndk_phosphins_an -0,04698 -0,21323 0,040596 0,325097 0,215246 0,526169 -2,70376 -2,51095 -2,64068 0,515669 1,220829 0,18552 -0,1211 -0,43579 -0,39557 0,137705 0,17622 -0,15554 0,406443 0,583981 Integrin-based_Cell_Migration_and_Adhesion -0,8983 -0,47769 -0,37787 -2,63129 -2,86526 -1,85587 -2,31201 -3,1125 -1,43134 0,0875 -2,55899 0,443307 -0,5847 -0,00753 -0,31336 -6,3389 -5,21163 -4,76746 0,406351 0,583981 MAPK_Signaling_Pathway_Cell_Survival 0,005097 -0,09786 -0,08708 0,040612 0,081802 0,293394 -0,79421 -0,85734 -0,95915 -0,76427 0,00214 -0,26319 0,062509 -0,03054 0,068489 0,205455 0,300626 0,479718 0,406717 0,584105 D-imyoi-inositol_145-trisphosphate_degradation 0,3356 -0,15936 -0,01612 -0,2592 -0,50062 -0,12522 -2,18341 -1,96943 -3,11596 -0,17074 -0,09156 -0,30228 -0,55121 -0,24711 -0,42423 -1,87196 -2,2549 -1,04001 0,407384 0,584524 reactome_Keratan_sulfate_degradation_Main_Pa -0,37224 0,316035 0,180626 -0,17258 0,118318 0,131705 -0,38715 -0,7752 -0,18712 1,424129 -0,58383 -0,71214 -0,94408 -0,59149 -0,85565 -1,38955 -0,0763 0,281108 0,40729 0,584524 reactome_Signaling_by_Robo_receptor_Main_Pa -0,2443 -0,18031 -0,20013 -0,38778 -0,29509 -0,25145 -2,30031 -2,20298 -2,18139 -0,59724 0,505044 0,230931 0,01765 0,500667 0,399389 -0,7532 -0,16172 -0,167 0,407586 0,584545 reactome_Molybdenum_cofactor_biosynthesis_M -0,11553 -0,04393 -0,1888 0,316701 -0,29059 -0,02415 0,374994 0,448331 0,20991 0,857164 0,143698 0,543338 0,068988 -0,15179 0,224006 -1,33369 -0,73203 -0,83847 0,407872 0,584685 reactome_Activation_of_caspases_through_apop 0,148032 0,137817 0,11567 -0,03018 -0,49262 0,132338 -0,16779 0,008411 -0,45575 0,72488 -0,41417 -0,5926 -0,10823 -0,33056 -0,37725 -1,52364 -1,33193 -1,24745 0,409456 0,586686 KEGG_Platelet_activation_Main_Pathway 0,164433 0,183224 -0,04599 -0,04504 2,01693 -0,68364 4,290826 3,196434 5,475651 2,375249 1,180762 2,705133 -1,17255 -2,18556 -1,3424 -0,14898 -2,38987 -2,62154 0,410539 0,587967 KEGG_Gap_junction_Main_Pathway -0,55523 0,293098 0,102977 1,165381 1,952321 1,206836 0,958843 0,426231 2,130191 2,847539 0,012845 0,943595 1,617529 2,585652 1,368987 9,04094 6,179746 4,854708 0,411315 0,588808 ILK_Signaling_Pathway_Apoptosis -0,04643 -0,05563 -0,1359 0,277946 0,766395 0,11797 -0,12296 -0,35546 -0,50546 -0,24529 0,524921 1,188294 0,221785 0,084172 0,200825 -0,55742 0,168272 0,164916 0,412445 0,589976 reactome_FGFR4_ligand_binding_and_activation_ -0,52595 -0,30497 -0,02531 -0,38718 -0,12373 -0,44961 -0,75936 -1,20818 0,088171 -0,04688 -0,83174 -0,41194 -0,19038 0,023049 -0,3209 0,597707 0,625539 0,122798 0,41251 0,589976 reactome_Post_transcriptional_silencing_by_sma -0,00911 -0,05324 -0,07027 0,018189 -0,45157 -0,41322 -0,39834 -0,4009 -0,57064 -0,31419 -0,2448 -0,42304 -0,07948 0,022895 -0,00218 0,181981 0,113705 0,421729 0,41273 0,59002 Akt_Signaling_Pathway_Apoptosis -0,03368 -0,16804 0,211271 -1,14987 0,473984 -1,19594 0,203703 0,069108 0,306978 -0,12982 1,613419 0,252805 0,716692 0,642843 0,365176 -0,31316 0,728132 0,893811 0,412996 0,590129 NCI_LKB1_signaling_events_Pathway_(tubulin_co -0,02032 -0,11296 -0,16736 -0,14548 0,778732 -0,03459 -0,11694 -0,15653 -0,1727 0,175874 -0,42727 1,216163 -0,00303 0,326163 0,137781 0,025276 -0,58796 -0,18201 0,413515 0,590385 NCI_Osteopontin_mediated_events_Pathway_(ru 0,077511 -0,01427 -0,08996 -0,27804 -0,91119 -0,44447 -0,05392 0,134593 -0,14425 -0,16019 -0,23914 -0,63425 -0,27894 -0,32854 -0,18624 -1,64251 -1,54062 -1,36553 0,413554 0,590385 biocarta_pten_dependent_cell_cycle_arrest_and_ 0,048949 -0,03332 -0,13127 -0,33789 -1,0108 -0,43135 -0,08443 -0,32705 -0,55299 -0,00554 0,112282 0,650877 0,445518 0,474112 0,63143 -1,87996 -1,22707 -0,71158 0,414739 0,591265 GDP-mannose_biosynthesis 0,114795 0,097613 0,091517 0,185956 0,203507 0,248257 -0,67657 -0,48235 -0,64818 -0,76905 -0,45289 -0,20588 -0,42653 -0,25435 -0,12545 0,083093 -0,29063 -0,08948 0,414711 0,591265 melatonin_degradation_II 0,046668 -0,10228 0,071533 -0,30799 -0,07301 -0,10052 -0,22249 -0,26725 -0,2513 -0,64133 -0,7107 -0,38168 0,047987 0,108886 0,286357 0,198259 0,204053 0,152241 0,414556 0,591265 reactome_PP2A_mediated_dephosphorylation_of 0,10013 0,032478 -0,02411 -0,25792 -0,80062 -0,72504 -0,02294 -0,03356 -0,05157 1,02631 1,26598 1,013224 0,23257 0,350919 0,151279 -0,55689 -1,24184 -0,55 0,414969 0,591321 NCI_Posttranslational_regulation_of_adherens_ju -0,28335 0,021806 0,011991 -0,80834 0,285533 -1,84464 -7,34625 -7,27354 -7,34272 -1,67069 0,712872 1,726024 -0,38904 -0,10027 -0,3432 -4,20496 -3,61482 -3,33346 0,415559 0,591892 adenosine_ribonucleotides_ide_novoi_biosynthes -0,18293 -0,23944 -0,32435 0,501459 -0,02973 -0,2735 0,224557 0,208415 0,181599 0,423421 0,166136 -0,09439 -0,51424 -0,46616 -0,09776 -0,875 -1,37487 -0,60324 0,416267 0,592357 CD40_Pathway_Cell_Survival 0,064229 0,085999 0,033969 0,270774 0,230146 0,076514 -0,20915 -0,17567 -0,16896 0,662208 0,502484 0,40801 0,295389 0,066174 0,249027 -0,31746 -0,45033 -0,22797 0,41611 0,592357 NCI_ErbB1_downstream_signaling_Pathway_(cell 0,301512 0,011217 -0,04921 -0,86807 -1,20488 -1,81199 0,753989 1,065725 0,305877 -1,49018 0,073096 -0,88655 0,091155 0,083914 0,040147 -0,34462 -0,29454 0,100068 0,416657 0,592643 biocarta_internal_ribosome_entry_Main_Pathway 0,284305 0,233592 0,003431 -0,22096 -0,78849 -0,60029 0,319276 0,899601 -0,39898 1,547893 -0,68549 -0,48057 -0,34226 -0,97976 -0,43551 -5,02311 -3,53824 -2,99114 0,41738 0,592842 biocarta_internal_ribosome_entry_Pathway_(tran 0,284305 0,233592 0,003431 -0,22096 -0,78849 -0,60029 0,319276 0,899601 -0,39898 1,547893 -0,68549 -0,48057 -0,34226 -0,97976 -0,43551 -5,02311 -3,53824 -2,99114 0,41738 0,592842 IGF1R_Signaling_Pathway_Apoptosis -0,21618 -0,23766 -0,44563 1,110062 -0,27748 0,096788 -0,61221 -0,62801 -0,87598 -0,81471 0,67958 -0,23573 0,163371 -0,19397 0,319096 -0,28418 0,347726 0,93716 0,417081 0,592842 NCI_Role_of_Calcineurin_dependent_NFAT_signa -0,0604 -0,12954 -0,09886 -0,00383 0,11339 0,374027 0,406995 0,351497 0,320803 -0,30327 -0,46734 -0,53973 0,311085 0,260712 -0,00575 0,73644 0,733418 0,38458 0,417749 0,592842 reactome_Acetylcholine_regulates_insulin_secret 0,072974 -0,14368 -0,21544 -0,21888 0,909397 0,014125 -0,98997 -0,95509 -1,10281 0,159639 -0,97312 -0,25752 -0,13259 -0,19449 -0,03526 -0,13296 -0,12179 0,470661 0,417655 0,592842 asparagine_biosynthesis -0,00959 0,033694 -0,05722 -0,5152 -0,3273 -0,02737 1,07E-05 0,015363 0,051409 -0,26867 0,144102 0,224753 0,069904 0,048177 0,158676 -0,72813 -0,88751 -0,64982 0,418846 0,593323 CREB_Pathway -4,58324 -3,22515 -2,87345 -1,93855 1,648762 -4,40608 -15,8602 -17,1017 -13,7504 -5,64213 -4,4427 -8,66407 5,42395 2,317148 7,012085 6,676155 4,936513 11,47608 0,418904 0,593323 GNAQ_Signaling_Events 0,192206 -0,06435 -0,13386 0,50292 0,798258 0,172743 -0,38652 -0,31999 -0,80119 0,109742 0,165767 -0,12937 -0,42424 -0,676 -0,44497 -1,12174 -1,06923 -0,28661 0,419138 0,593323 KEGG_Tight_junction_Main_Pathway -1,59897 -0,83564 -0,97412 -2,75184 -3,88719 -2,83154 -1,87397 -3,82472 0,13888 -0,77357 -3,10271 -6,0769 0,719945 1,381723 1,260097 -1,39582 -0,69021 -2,38674 0,418687 0,593323 MAPK_Signaling_Pathway_Gene_Expression_Cell_ 0,389335 -0,36227 -0,25294 -0,30924 -0,56034 -0,76062 -6,17058 -5,49098 -6,44441 1,410245 3,193383 0,760671 0,807328 0,681877 0,881475 -3,30314 -3,70156 -3,59276 0,418872 0,593323 mTOR_Pathway_Ribosome_Biogenesis 0,061457 -0,04235 -0,03321 0,110927 -0,27729 -0,63348 0,597204 0,636228 0,413384 0,141331 0,590319 0,276373 0,115318 0,184896 0,350773 -1,28468 -1,04436 -0,86335 0,419299 0,593323 reactome_L13a_mediated_translational_silencing 3,214971 1,245557 0,802403 -9,46972 -12,0115 -13,5534 8,831133 10,51107 5,160193 -4,2646 7,832923 5,192348 -2,37654 -2,01705 0,989479 -54,0644 -44,3426 -38,0193 0,419421 0,593323 ketogenesis 0,108255 -0,02057 0,024602 -0,1283 -0,64052 -0,54511 0,452644 0,453575 0,35139 -0,63261 -0,2111 0,543042 0,350615 0,064831 0,430333 -0,7047 -0,90473 -0,74583 0,419679 0,593419 biocarta_hiv_1_nef_negative_effector_of_fas_and 0,207841 -0,05677 0,095531 -0,23746 0,37749 -0,11925 -1,78317 -1,39644 -1,93578 -0,1029 -1,34002 -0,19704 -0,34264 -0,53154 -0,78232 -1,47477 -1,24572 -0,3911 0,420168 0,59384 biocarta_basic_mechanism_of_action_of_ppara_p -0,26897 0,017994 -0,17118 -0,70734 -0,10993 -0,04428 -0,54288 -0,51263 -0,32274 -0,27718 -0,13883 0,324519 0,313053 0,1053 0,396956 0,624967 0,665681 0,773039 0,420603 0,594185 EGF_Pathway_Cell_Survival -0,31278 -0,24725 -0,355 0,250015 0,54941 -0,40742 0,765936 0,88119 0,786211 0,999005 1,125737 1,167404 0,355103 0,01344 0,391513 -1,81376 -0,93767 -0,68394 0,421058 0,594559 KEGG_Salmonella_infection_Main_Pathway -0,10757 -0,92652 -0,90738 -2,06412 -2,50363 -3,51756 -4,21331 -3,88465 -5,22109 -3,07183 0,182411 1,410143 0,053147 -1,12436 -0,06321 -7,57964 -6,50669 -5,5246 0,421672 0,594939 reactome_Tachykinin_receptors_bind_tachykinins 0,023988 0,022746 0,110541 0,078663 -0,12233 0,582073 -0,12421 0,007701 0,138348 0,13236 -0,77987 -0,00344 -0,21128 -0,27225 0,003473 0,716278 0,581529 0,808093 0,421709 0,594939 KEGG_Autoimmune_thyroid_disease_Main_Pathw -0,24151 -0,04636 -0,10347 -0,64551 0,110981 0,606512 0,206991 0,343059 0,394058 1,453264 -0,70412 0,013955 -0,17733 0,02527 0,048657 0,457331 0,746296 0,371121 0,422767 0,595662 KEGG_Graft_versus_host_disease_Main_Pathway -0,24151 -0,04636 -0,10347 -0,64551 0,110981 0,606512 0,206991 0,343059 0,394058 1,453264 -0,70412 0,013955 -0,17733 0,02527 0,048657 0,457331 0,746296 0,371121 0,422767 0,595662 reactome_Formation_of_a_pool_of_free_40S_su 2,894203 0,926044 0,514561 -9,57979 -11,594 -13,1742 8,520555 9,975784 5,350214 -4,62104 7,000686 4,74415 -2,26153 -1,351 0,997631 -49,2949 -41,3316 -35,7247 0,422796 0,595662 NCI_Signaling_events_mediated_by_PRL_Pathway -0,07318 0,013676 0,009474 -0,15592 0,008002 -0,24304 -0,66598 -0,60858 -0,57561 -0,10713 -0,1025 0,146302 -0,03172 -0,04391 0,065734 -0,02824 0,109627 -0,14251 0,423482 0,596359 Gamma-Aminobutyric_Acid_A_Receptor_Pathway 0,062985 -0,13767 0,160171 -0,62639 -1,34716 -1,72442 -2,89695 -2,97264 -3,31216 -1,40796 1,994013 1,39065 0,712362 0,34746 0,946794 -0,71485 -0,12647 0,505283 0,424516 0,597485 Rapoport-Luebering_glycolytic_shunt 0,031439 -0,03032 0,033455 -0,15187 -0,06393 -0,09253 0,007848 0,145818 0,030979 0,468105 0,13722 0,222891 0,086041 0,052922 -0,05588 -0,94879 -0,7654 -0,8117 0,424665 0,597485 reactome_Removal_of_aminoterminal_propeptid -0,1545 -0,01255 0,091059 -1,02933 -0,27483 0,821912 -0,1927 -0,61845 0,347173 -1,00566 0,093709 0,820425 0,233966 0,009325 0,342763 1,434079 0,993811 0,514811 0,424903 0,597549 adenine_and_adenosine_salvage_I 0,013768 -0,0544 0,007219 -0,19509 -0,06012 0,015236 -0,14044 -0,14419 -0,07971 -0,57458 -0,14041 -0,12418 0,029943 0,114372 0,104558 0,035553 0,24203 -0,03666 0,42571 0,598414 biocarta_extrinsic_prothrombin_activation_Main_ -0,20548 -0,09602 0,009637 -0,80439 -0,76119 -0,30151 0,133529 -0,18222 0,569219 -1,48255 -1,94125 -0,23066 0,70359 0,124109 -0,47833 2,93121 1,44779 1,443906 0,426269 0,59866 KEGG_Alanine_aspartate_and_glutamate_metabo 0,055362 -0,36186 -0,10223 -0,97869 -2,5658 -1,28288 -1,22191 -0,79836 -2,13302 0,346978 1,186312 -0,20895 0,85019 0,290053 0,846809 -6,4471 -3,34874 -2,62921 0,426247 0,59866 Protein_kinase_A_Pathway 0,065946 0,005426 0,033105 0,395624 0,223113 -0,23546 -0,03879 -0,05436 -0,18535 0,316468 0,153323 0,188351 0,961203 0,736941 0,593843 0,941142 0,418238 0,404374 0,42704 0,599473 reactome_Glucagon_type_ligand_receptors_Main -0,17485 -0,01966 -0,12365 1,577495 1,083278 0,823993 0,216016 -0,25982 0,475757 -1,2534 1,221715 0,333437 -0,37797 -0,46108 -0,17557 0,059787 -0,14551 0,681627 0,42746 0,599792 NCI_TNF_receptor_signaling_pathway__Main_Pat -0,04019 -0,43424 -0,46554 -2,55336 -0,778 -3,47876 -5,99414 -5,53278 -6,29038 -1,63201 -2,36781 0,141301 0,292967 0,233979 -0,166 -4,12764 -4,79574 -2,4419 0,428018 0,600304 KEGG_Leukocyte_transendothelial_migration_Ma -0,52342 -0,55524 -0,87074 1,63585 -2,52625 -1,98592 -4,62971 -5,20481 -4,03764 2,433498 1,832804 1,506039 0,830182 0,396355 0,656501 -4,95002 -4,37111 -4,70441 0,428461 0,600385 reactome_Signaling_by_BMP_Main_Pathway 0,029613 0,208958 -0,08182 0,058658 -0,77864 -1,44152 1,349183 0,896568 0,565042 -1,13173 -0,11287 -0,09034 -0,18726 -0,68582 -0,25007 -1,25102 -0,65501 0,306231 0,428345 0,600385 reactome_SHC_activation_Main_Pathway 0,042026 -0,04586 -0,07837 -0,1854 -0,13498 -0,56436 -0,64936 -0,72772 -0,7379 0,66457 0,610728 0,01062 0,314542 -0,03207 0,044618 -0,57998 -0,05133 -0,13235 0,429122 0,601041 biocarta_cell_cycle_g2_m_checkpoint_Main_Path 0,090888 0,183983 0,077684 1,101339 0,47085 0,276669 1,221106 1,435605 0,862766 3,325901 2,274528 1,320733 -0,44234 -0,5177 -0,15851 -1,00529 -0,32514 -0,82393 0,429759 0,601662 4-hydroxyproline_degradation -0,12166 -0,04237 -0,06605 -0,36893 -0,12519 -0,32214 0,038055 -0,05446 0,026638 -0,36626 -0,28464 0,328637 0,326725 0,392629 -0,00673 0,418295 0,927469 0,455669 0,430912 0,603006 Akt_Signaling_Pathway_JNK_mediated_apoptosis 0,052649 -0,09002 0,384047 -1,43596 0,561956 -1,33559 0,752977 0,64739 0,96909 0,575512 1,547093 -0,59003 0,556903 0,47582 0,230175 -0,68981 0,419168 0,32663 0,43137 0,603375 reactome_Condensation_of_Prophase_Chromoso 0,431296 -0,09321 -0,54208 0,177898 -0,73661 -2,1289 7,055882 7,989708 5,713197 0,089091 -0,16741 -1,22389 -1,53333 -2,12565 -0,30552 -7,68986 -4,28187 -3,86246 0,432093 0,603863 reactome_Translation_initiation_complex_format 1,53471 0,869988 0,51438 -4,73744 -5,48579 -5,98922 4,068946 5,08046 2,086378 -2,09562 4,462772 3,005687 -0,97059 -2,18585 0,123058 -27,5481 -22,7101 -18,7244 0,432106 0,603863 Cellular_Apoptosis_Pathway 2,790215 1,47545 1,141054 6,091493 2,545134 6,550772 11,80354 12,86827 10,38309 -0,21791 4,667837 6,83155 -4,93777 -3,8809 -6,19119 -0,66312 2,555786 0,36909 0,432788 0,604545 reactome_N_glycan_trimming_in_the_ER_and_Ca 0,01264 -0,055 -0,0503 0,075031 -0,15952 0,031267 0,127582 0,156455 -0,09721 -0,09446 0,187632 0,334317 -0,27777 -0,24135 -0,12757 -0,87874 -0,82133 -0,96328 0,433306 0,604726 reactome_Toxicity_of_botulinum_toxin_type_G_B -0,02474 -0,06765 -0,12107 0,07897 -0,17545 -0,60256 -1,47746 -1,36562 -1,67444 -1,10998 -2,10375 -1,03882 0,23437 0,012502 -0,07037 0,337896 0,700496 0,297319 0,433161 0,604726 reactome_Vitamin_B5_pantothenate_metabolism 0,031394 0,017433 -0,08095 0,820334 -0,2801 0,630865 -0,07527 -0,13272 -0,35068 0,801832 0,423073 0,046925 -0,05958 -0,3998 -0,26556 -0,75279 -0,96718 -1,01673 0,433522 0,604756 IL-6_Pathway -0,05109 0,45252 0,080369 -2,00434 -2,35272 -1,16929 1,071678 2,086743 0,460005 2,178661 0,344351 -0,45378 -0,23181 1,494251 1,543319 -7,41577 -4,68575 -3,51267 0,434375 0,605674 NCI_IL6_mediated_signaling_events_Pathway_(ce 0,022008 -0,01544 0,044021 -0,34275 -0,04449 -0,1444 -0,31602 -0,29005 -0,33838 -0,54486 -0,11284 -0,3704 0,100872 0,214462 0,121083 0,781724 0,63788 0,723754 0,436473 0,607784 NCI_IL6_mediated_signaling_events_Pathway_(ce 0,022008 -0,01544 0,044021 -0,34275 -0,04449 -0,1444 -0,31602 -0,29005 -0,33838 -0,54486 -0,11284 -0,3704 0,100872 0,214462 0,121083 0,781724 0,63788 0,723754 0,436473 0,607784 NCI_IL6_mediated_signaling_events_Pathway_(m 0,022008 -0,01544 0,044021 -0,34275 -0,04449 -0,1444 -0,31602 -0,29005 -0,33838 -0,54486 -0,11284 -0,3704 0,100872 0,214462 0,121083 0,781724 0,63788 0,723754 0,436473 0,607784 glutamine_biosynthesis 0,035533 0,023648 0,021375 -0,22016 0,186501 0,143478 0,133716 0,169636 0,082902 -0,09718 -0,00039 -0,08251 -0,15102 -0,12172 0,112147 -0,31218 -0,13832 -0,12145 0,436766 0,60792 reactome_Acyl_chain_remodeling_of_CL_Main_P -0,02315 -0,07764 -0,21143 -1,11728 -1,07722 -1,16111 1,252575 1,46816 0,909999 -0,76226 -0,28642 0,060291 -0,24058 0,227236 -0,10941 -2,50008 -2,57889 -2,07089 0,437271 0,608079 reactome_TGF_beta_receptor_signaling_in_EMT_ -0,07011 -0,17598 -0,19783 -0,70288 -0,09847 -0,92001 -0,77325 -0,76935 -0,94502 0,298494 0,378606 0,969467 0,360088 0,30072 0,217885 -2,26173 -2,00673 -1,34298 0,437262 0,608079 NCI_Arf6_downstream_Pathway_(regulation_of_a -0,01033 -0,06193 -0,05218 0,003801 -0,71163 -0,95744 -0,1247 -0,03206 -0,236 0,549757 -0,75466 -0,14834 0,553332 0,561448 0,323315 -0,75852 -0,68898 -0,66458 0,43861 0,609398 NCI_Arf6_downstream_Pathway_(ruffle_organiza -0,01033 -0,06193 -0,05218 0,003801 -0,71163 -0,95744 -0,1247 -0,03206 -0,236 0,549757 -0,75466 -0,14834 0,553332 0,561448 0,323315 -0,75852 -0,68898 -0,66458 0,43861 0,609398 Akt_Signaling_Pathway_Cell_Survival -0,00731 0,093773 0,347331 -0,81537 -0,19414 -1,63753 -1,55115 -1,68453 -1,82829 -0,48541 1,32208 -0,88987 0,766063 0,760728 0,47662 -3,20386 -1,71438 -0,63536 0,440631 0,609926 KEGG_Lysine_biosynthesis_Main_Pathway 0,08224 0,002274 0,024672 -0,25237 -0,62043 -0,69827 0,170769 0,238461 -0,06342 -0,01683 -0,05528 -0,54514 0,249351 0,409397 0,30178 -1,02313 -0,77782 -0,35106 0,44035 0,609926 KEGG_TNF_signaling_Main_Pathway 0,249774 -0,43312 -0,56915 -2,18794 0,122807 -1,89176 -1,45044 -0,80076 -2,73549 -0,07858 -0,60076 1,645057 1,098196 1,427131 1,774061 -3,44244 -2,35937 -0,09997 0,440624 0,609926 NCI_DNA_PK_pathway_in_nonhomologous_end_ 0,527227 -0,084 0,191555 -0,48954 -0,68599 -0,27124 -1,02348 -0,5884 -1,51856 -0,19199 -0,19697 -0,74361 -0,46046 -0,09947 0,438063 -2,26731 -1,57198 -0,43106 0,439743 0,609926 NCI_DNA_PK_pathway_in_nonhomologous_end_ 0,527227 -0,084 0,191555 -0,48954 -0,68599 -0,27124 -1,02348 -0,5884 -1,51856 -0,19199 -0,19697 -0,74361 -0,46046 -0,09947 0,438063 -2,26731 -1,57198 -0,43106 0,439743 0,609926 reactome_EPHA_mediated_growth_cone_collaps -0,25494 -0,24265 -0,43536 -1,19135 -1,98238 -2,0277 -2,95894 -3,33775 -3,62142 0,356181 0,594099 0,050453 0,438246 0,998192 1,124037 -0,81429 0,972603 0,480536 0,440273 0,609926 reactome_Role_of_phospholipids_in_phagocytosi -0,34943 -0,2211 -0,11524 -0,36665 -0,20787 0,077548 -0,23727 -0,5304 -0,16273 3,103809 0,034948 1,342056 0,901553 1,098972 0,449967 0,752964 0,72262 0,761556 0,440574 0,609926 reactome_Sodium_Proton_exchangers_Main_Pat -0,21448 -0,13768 0,060747 0,414709 0,762169 -0,85989 0,134316 -0,08129 0,040041 0,396799 0,250686 0,240846 -0,10053 -0,59511 -0,06802 1,016607 -0,2313 -0,0114 0,440753 0,609926 retinoate_biosynthesis_I -0,26481 -0,02053 -0,0879 -1,38745 -0,41169 -0,38364 -0,40275 -0,57407 -0,02807 0,549598 -0,74068 -0,46759 0,345172 0,584768 0,288723 1,483669 0,659289 0,131954 0,439598 0,609926 KEGG_Biosynthesis_of_unsaturated_fatty_acids_M 0,10888 -0,13118 -0,11535 -2,33159 -2,23554 -1,66086 -1,41775 -1,05276 -1,79204 3,134615 1,89834 1,875878 -0,96881 -1,00047 -0,42046 -5,23229 -3,96772 -3,19498 0,442359 0,610251 KEGG_Pathways_in_cancer_Main_Pathway -3,84002 -3,57316 -3,11368 -6,07854 -0,75315 -5,92076 -9,07743 -9,74981 -7,8663 -1,0785 -4,37674 1,178587 0,607064 1,144815 0,849628 -6,05261 -3,25602 -2,43802 0,441464 0,610251 NCI_E_cadherin_signaling_in_keratinocytes_Pathw -0,39347 -0,08335 -0,08384 -0,41524 0,140342 -0,57146 -1,39304 -1,36015 -1,24223 0,059573 1,120441 0,890792 -0,61031 0,132167 -0,21119 -1,09598 -0,12447 -0,66935 0,442214 0,610251 NCI_RAC1_signaling_Pathway_(actin_filament_de 0,023779 -0,01607 0,100018 -0,34808 0,424403 0,182243 -0,45474 -0,44047 -0,59284 0,280244 0,305064 0,048488 0,609719 0,572663 0,559237 1,385515 1,328729 1,392717 0,442212 0,610251 NCI_RhoA_signaling_Pathway_(Pathway_positive_ -0,01662 0,016982 0,004618 0,115381 -0,02666 0,061337 -0,18244 -0,13979 -0,12068 0,179353 0,263875 -0,01886 -0,07028 -0,12481 -0,04989 -0,42016 -0,42816 -0,40513 0,441505 0,610251 propionyl-CoA_degradation 0,191828 0,151379 0,047122 -0,63564 -0,69605 -0,33376 0,179997 0,286207 -0,29024 -0,10062 0,444719 0,606716 0,024799 -0,01835 0,176303 -2,52741 -2,05701 -2,20745 0,442011 0,610251 TRAF_Pathway_Apoptosis 0,196488 -0,20963 -0,02722 0,217107 0,637452 0,159945 -1,79639 -1,55266 -2,04577 0,113263 0,362392 1,265369 -0,53997 -0,38821 -1,01067 -3,1148 -2,32292 -1,46349 0,44184 0,610251 glycogen_biosynthesis 0,160707 0,139959 0,145257 -0,50222 -0,24048 -1,60289 -1,03797 -0,86013 -1,21767 0,250286 0,519019 1,015064 0,374502 0,509318 0,354988 -2,96595 -2,37428 -3,04533 0,443181 0,611115 reactome_P2Y_receptors_Main_Pathway -0,30087 0,073107 0,011985 2,422946 0,772847 1,534336 -0,43186 -0,62586 0,090506 0,926591 1,483948 -0,04353 -0,08259 -0,13789 -0,5066 0,255673 -0,15399 0,080309 0,443554 0,611358 reactome_NOD1_2_Signaling_Pathway_Main_Pat 0,556213 -0,84121 -0,16788 0,245312 -1,0198 -1,06985 -0,36636 0,740915 -1,31829 0,915924 -0,39001 -1,68172 -0,89022 -0,56213 -0,05154 -2,67735 -2,36747 -1,78145 0,443862 0,611513 serine_and_glycine_biosynthesis 0,078921 0,009213 -0,05536 -1,06251 -0,9013 -0,23058 1,239329 1,365324 1,055972 -0,84465 0,445409 -0,15053 -0,26073 -0,31182 -0,41098 -2,92593 -2,58105 -1,95616 0,44459 0,612245 Akt_Signaling_Pathway_Increased_GLUT4_translo 0,067425 -0,0933 0,396647 -1,40947 0,535992 -1,44965 0,587366 0,570519 0,720841 0,289235 1,322219 -0,35411 0,853147 0,785118 0,520462 -0,17506 0,918269 0,923281 0,445417 0,613113 biocarta_role_of_brca1_brca2_and_atr_in_cancer 0,173186 -0,11212 -0,05084 0,172893 0,309297 -0,14067 -0,05209 0,388617 -0,57122 0,713997 0,847388 0,143061 -0,31535 -0,36874 -0,44695 -3,08653 -1,81115 -1,22377 0,446092 0,613325 reactome_Autointegration_results_in_viral_DNA_ -0,14318 -0,19068 -0,10989 -0,47071 -0,2182 -0,5067 -0,03814 0,034312 -0,04213 0,029463 0,07332 -0,44139 9,64E-05 -0,10515 0,025583 -0,72011 -0,82995 -0,60974 0,446359 0,613325 reactome_Endosomal_Vacuolar_Main_Pathway 0,49616 0,348583 0,23359 -0,99634 -0,70743 -0,82732 -0,81112 -0,64111 -1,06479 1,971405 1,428188 0,477594 0,633381 0,151833 0,842389 -5,11471 -4,90515 -3,17664 0,446135 0,613325 reactome_Integration_of_viral_DNA_into_host_g -0,14318 -0,19068 -0,10989 -0,47071 -0,2182 -0,5067 -0,03814 0,034312 -0,04213 0,029463 0,07332 -0,44139 9,64E-05 -0,10515 0,025583 -0,72011 -0,82995 -0,60974 0,446359 0,613325 GDP-glucose_biosynthesis_II 0,054794 -0,0857 -0,08084 -0,19538 0,384826 -0,39898 -0,13394 -0,14061 0,132054 -0,82291 0,091814 -0,27344 0,442131 0,027871 0,333976 0,278013 0,286134 0,155811 0,447121 0,614101 Akt_Signaling_Pathway_ERK_mediated_apoptosis 0,019781 -0,13885 0,319225 -1,24067 0,266692 -1,43247 0,190084 0,163129 0,390645 -0,09308 1,031079 -0,57704 0,756049 0,53379 0,292722 -0,10285 0,657861 0,702779 0,448691 0,615715 reactome_Signaling_by_ERBB2_Main_Pathway 0,155537 -0,13732 0,104633 -1,52994 -0,55512 -2,11898 0,893142 1,000161 0,467283 -0,59058 -0,17271 0,057456 0,349976 0,327543 0,166967 -4,17228 -2,85894 -2,21667 0,448614 0,615715 putrescine_biosynthesis_I 0,036565 0,053217 0,004258 0,116435 -0,19425 -0,04799 0,06369 0,178422 0,039566 0,158446 0,455168 0,428042 -0,10526 0,028721 -0,24499 -0,46078 -0,30049 -0,21912 0,448922 0,615761 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(ne 0,019117 -0,12706 -0,10545 -0,79896 -0,6645 -2,60659 -2,12826 -1,7359 -1,76226 0,952391 0,165051 0,992919 -0,19073 0,303829 -0,44406 -2,49373 -1,32898 -0,81123 0,449634 0,616466 biocarta_keratinocyte_differentiation_Pathway_( 0,082463 -0,15709 0,022626 -0,46126 -0,63677 -0,61639 -1,82441 -1,546 -1,91513 0,616463 -0,48204 -0,52261 0,060161 0,110399 0,011912 -0,41107 -0,09744 -0,0403 0,4504 0,617017 mTOR_Pathway_Microtubule_Organization -0,15811 -0,17608 -0,11261 -0,89904 -0,81037 0,207763 -7,16268 -7,13073 -7,7745 -0,041 -1,32267 0,898413 1,145434 0,14326 0,446016 -1,08747 -1,12018 0,597195 0,451027 0,617017 reactome_FGFR3c_ligand_binding_and_activation -0,43574 -0,19511 -0,08403 -0,64666 -0,12162 -0,42432 -0,66327 -1,02202 -0,26668 0,728034 -0,63956 0,008786 -0,10232 -0,29383 -0,24702 -0,22662 -0,08283 -0,68348 0,450707 0,617017 reactome_NF_kB_is_activated_and_signals_surviv 0,157558 -0,05967 -0,00518 -1,57828 -0,17851 -0,82404 -1,23911 -1,24603 -1,48142 0,129348 -0,31326 1,198203 0,74226 -0,16091 0,512952 -2,6428 -2,88748 -1,92485 0,450886 0,617017 reactome_Signaling_by_FGFR3_mutants_Main_Pa -0,43574 -0,19511 -0,08403 -0,64666 -0,12162 -0,42432 -0,66327 -1,02202 -0,26668 0,728034 -0,63956 0,008786 -0,10232 -0,29383 -0,24702 -0,22662 -0,08283 -0,68348 0,450707 0,617017 KEGG_Thyroid_cancer_Main_Pathway -0,00058 -0,13966 -0,18851 -0,46532 -0,35145 -0,63007 -0,60745 -0,48113 -0,88006 -0,06879 0,962717 0,410717 -0,40658 -0,16897 -0,15527 -1,1048 -0,93066 -0,60867 0,451825 0,617837 NCI_IL2_signaling_events_mediated_by_PI3K_Ma 0,061143 0,100583 -0,14937 -2,02231 0,135861 -2,54586 0,405657 0,317947 -0,14047 -0,0092 -0,09471 0,193966 0,335841 -0,0282 0,648805 -5,39732 -3,46468 -2,55831 0,453224 0,619479 reactome_Beta_oxidation_of_hexanoyl_CoA_to_b 0,066052 -0,05807 0,044481 -0,18845 0,175409 -0,37207 0,600081 0,759953 0,521543 0,951509 0,262676 0,720929 -0,03553 0,004427 -0,22548 -1,99857 -2,00816 -1,76902 0,453439 0,619502 reactome_Viral_mRNA_Translation_Main_Pathwa 2,85335 0,81548 0,464493 -8,96762 -10,4734 -13,0154 7,962871 9,214591 5,126508 -3,85112 6,063481 4,680678 -2,29369 -1,41337 0,71012 -44,5527 -37,7857 -32,4198 0,453731 0,619628 KEGG_Glycolysis_Gluconeogenesis_Main_Pathwa -0,27993 0,388011 0,25738 -5,23525 -1,61638 -2,9367 0,61744 0,434748 1,921907 0,203373 0,796901 -0,06697 1,707168 1,834611 0,43817 -6,63354 -8,84332 -6,4622 0,454349 0,6202 reactome_PKA_activation_in_glucagon_signalling_ -0,38461 -0,13882 -0,21474 -0,41908 0,239223 -0,44862 -2,20413 -1,9537 -2,03466 -1,07318 -1,33514 0,257234 -0,56003 0,412488 0,626993 0,03254 0,209398 0,416126 0,455163 0,621039 NCI_Aurora_A_signaling_Pathway_(negative_regu -0,16317 0,029139 -0,05302 -0,50075 -0,46091 -0,22393 0,963152 0,892555 1,045545 -1,38021 -0,88267 -0,74022 -0,38383 -0,25077 -0,31467 0,466083 0,759129 0,450807 0,455894 0,621765 KEGG_Glycosphingolipid_biosynthesis_globo_seri 0,189263 -0,16566 -0,37276 0,570852 1,14534 0,693709 -2,91479 -2,87824 -2,60986 0,949981 0,516997 -0,26263 -0,68475 -0,24104 -0,2062 -0,88788 -1,076 0,509301 0,456114 0,621793 NCI_Aurora_A_signaling_Pathway_(centrosome_d -0,10755 -0,01728 -0,07138 -0,25129 -0,6372 -0,13635 1,074053 1,06391 0,860016 -1,32219 -0,37886 -0,79541 -0,02958 0,226694 0,116 1,045135 1,670022 1,41846 0,456593 0,622173 biocarta_melanocyte_development_and_pigment -0,08077 -0,17747 -0,24165 -1,11891 -1,07079 -1,8539 -1,86862 -1,88755 -2,36699 -1,67503 -0,46299 -0,59644 -0,23648 -0,36056 -0,14954 -2,40368 -2,76048 -1,81515 0,457473 0,622827 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(D -0,00828 0,0701 0,058668 -0,69436 0,025145 -0,09339 -0,59118 -0,44298 -0,62014 -0,38829 0,253694 -0,51032 -0,12981 0,089688 -0,15413 -0,93885 -0,94311 -0,30363 0,457311 0,622827 Akt_Signaling_Pathway_Promotes_Adipogenesis -0,04374 -0,17698 0,293693 -1,47722 0,362385 -1,51261 0,068004 0,056624 0,14608 -0,16996 1,218414 -0,41917 0,566186 0,54371 0,292146 -0,35966 0,361621 0,604433 0,459953 0,625202 biocarta_agrin_in_postsynaptic_differentiation_M -0,1818 -0,71608 -0,19195 -1,56436 -2,20325 -2,82063 -3,28239 -2,88593 -3,56812 0,52949 0,645375 1,375612 0,515655 1,019727 0,854348 -1,04927 -1,63481 0,253879 0,460221 0,625202 methylglyoxal_degradation_III -0,05487 -0,0814 -0,04799 -0,6279 -0,52513 -0,62892 -0,56493 -0,61073 -0,59539 1,34722 0,059154 0,736031 0,031675 0,215826 -0,02634 -0,93046 -0,50521 -0,88857 0,460037 0,625202 NAD_ide_novoi_biosynthesis 0,018159 0,124834 0,102729 -1,25105 0,327132 0,37995 -2,51586 -3,30383 -2,45176 -0,6709 -0,26023 -0,54134 0,241981 -0,02294 -0,5115 1,087164 1,28731 -0,0501 0,45979 0,625202 reactome_Nonsense_Mediated_Decay_NMD_ind 2,8583 0,747536 0,346489 -9,41665 -11,0589 -12,7366 7,803379 9,099096 4,722389 -4,18394 6,441837 4,584274 -2,20271 -1,78653 0,743664 -44,7941 -37,9204 -32,9349 0,460059 0,625202 fatty_acid_beta-oxidation_unsaturated_odd_num -0,06183 -0,10739 -0,07328 0,258426 -0,21379 -0,07552 0,303032 0,256857 0,145232 0,328086 0,898934 0,750692 0,123033 0,337724 -0,02139 -0,83525 -1,04072 -1,0031 0,461306 0,62613 reactome_Toxicity_of_botulinum_toxin_type_C_B -0,11638 -0,04786 -0,11363 0,238176 0,407572 0,379076 -0,55061 -0,72698 -0,56444 -1,26245 -0,57386 -1,13169 0,023204 0,184138 0,039367 3,123373 2,993519 3,549137 0,461217 0,62613 KEGG_Glioma_Main_Pathway -0,55227 -1,14624 -0,97669 -1,00629 -0,56337 -2,32458 -3,57706 -2,95716 -4,46807 -1,45061 -0,78712 -0,29661 0,294625 0,130099 1,8944 -3,89809 0,039096 1,548564 0,462087 0,626644 NCI_ErbB2_ErbB3_signaling_events_Pathway_(my 0,094171 -0,01211 -0,09945 -1,0635 -0,11907 -0,4639 0,168989 0,371183 -0,02588 -0,0362 -0,23389 -0,12305 -0,09181 -0,10681 0,15577 -2,19401 -1,3164 -0,74182 0,4619 0,626644 biocarta_vegf_hypoxia_and_angiogenesis_Main_P -0,22061 -0,5625 -0,43914 -1,63928 0,469265 -1,23751 -3,39649 -3,43651 -3,69067 1,412245 0,306852 -1,23791 0,879923 0,478114 0,576165 -2,14645 -1,01561 -0,57794 0,462351 0,62673 CDK5_Signaling_in_Neurons -0,49973 -0,58375 -0,53276 -1,20102 1,098472 -0,48159 -2,84282 -2,88317 -3,37062 0,578043 2,583719 2,045678 1,249914 1,078496 1,055815 -2,14616 -1,36515 -0,39502 0,462959 0,627008 IL-2_Pathway_Actin_Reorganization -0,13871 -0,02844 -0,07987 -0,26126 0,078675 -0,45876 -1,21915 -1,27013 -1,19907 0,318493 1,365607 2,498018 0,526299 0,622678 0,930422 -1,77715 -1,91446 -1,84936 0,462866 0,627008 KEGG_Hepatitis_B_Main_Pathway -0,30944 -0,95265 -0,55109 -1,76534 -1,61437 -3,06928 -0,33545 0,344382 -0,97125 1,50221 1,028902 1,6466 -0,14384 -0,68663 1,336092 -2,70701 -1,96983 -1,12381 0,463289 0,627182 ILK_Signaling_Pathway_Cell_Migration_Retraction -0,61355 -0,51157 -0,30501 -0,47498 -0,2815 -0,32821 -3,45849 -2,96715 -3,04383 2,582478 -0,09795 3,575959 0,109567 0,11884 0,977171 -3,73011 -3,35342 -3,4577 0,465426 0,629351 leukotriene_biosynthesis -0,12082 0,015826 0,097196 0,604038 -0,63645 0,32108 0,351732 0,1253 0,512929 -0,48581 -0,20651 0,024682 0,58387 0,291805 0,665247 0,790552 0,816284 0,138108 0,465497 0,629351 NCI_Class_I_PI3K_signaling_events_mediated_by_ 0,174308 0,052054 -0,39532 0,754477 1,406931 1,315568 -2,38887 -2,13372 -3,38721 0,669126 1,444597 1,46735 -0,31046 0,416677 -0,32833 -0,6094 -0,58102 -0,12196 0,465332 0,629351 NCI_Alpha9_beta1_integrin_signaling_events_Ma -1,01898 -0,44031 -0,50204 -2,88313 -0,74321 -3,2593 -2,31354 -2,44631 -2,03613 1,281485 -1,18092 0,17996 1,401862 0,721357 0,727085 0,742341 0,772857 0,123161 0,465745 0,62941 reactome_Synthesis_of_PC_Main_Pathway 0,165797 -0,13919 -0,13883 -1,251 -1,73607 -1,99927 -0,71553 -0,86105 -0,98301 -2,72576 -1,48626 -1,55538 -0,26093 -0,17617 -0,02174 -2,86676 -1,68994 -1,16815 0,465945 0,62941 biocarta_rho_selective_guanine_exchange_factor -0,26913 -0,04873 -0,18918 0,33729 -0,06349 -0,55978 -0,74062 -0,82994 -0,87095 -0,00638 0,361741 0,180068 -0,84429 -1,23727 -0,7733 -3,32046 -2,51357 -2,47502 0,467517 0,63126 NCI_CD40_CD40L_signaling_Pathway_(regulation_ -0,02155 -0,01129 -0,04828 -0,12824 -0,83396 0,200635 -0,51579 -0,42709 -0,64006 -0,314 0,573037 -0,1484 0,166783 0,093098 0,100695 -0,70692 -0,56386 -0,80641 0,468434 0,631461 NCI_CD40_CD40L_signaling_Pathway_(regulation_ -0,02155 -0,01129 -0,04828 -0,12824 -0,83396 0,200635 -0,51579 -0,42709 -0,64006 -0,314 0,573037 -0,1484 0,166783 0,093098 0,100695 -0,70692 -0,56386 -0,80641 0,468434 0,631461 reactome_Dissolution_of_Fibrin_Clot_Main_Pathw0,016376 0,136425 -0,13423 -1,48564 -1,70012 -1,04976 -5,30544 -5,02387 -5,10386 -2,39283 -0,04387 -0,62228 1,344249 0,598174 0,909664 -1,46963 -0,49945 -1,28046 0,467889 0,631461 reactome_Hydrolysis_of_LPC_Main_Pathway 0,045374 0,275356 0,172381 -0,64752 -1,19423 -1,00174 0,45701 0,249056 0,686946 -0,76095 -1,64854 -0,62889 -0,18724 -0,36387 -0,62294 -0,95885 -0,12031 -0,65843 0,468477 0,631461 biocarta_il12_and_stat4_dependent_signaling_pa 0,255705 -0,20432 0,058472 -0,93786 0,035174 0,173261 0,775373 0,802237 0,740257 -1,03261 -0,85922 -0,51515 0,044145 0,777655 1,051652 0,557225 1,114381 -0,10224 0,469887 0,632813 reactome_Eukaryotic_Translation_Termination_M 2,815915 0,855026 0,461644 -9,24697 -10,6725 -13,1251 7,870212 9,050682 4,998703 -3,70215 6,308636 4,636639 -2,20094 -1,52375 0,949639 -43,8935 -37,3767 -32,2598 0,469742 0,632813 reactome_Classical_Kir_channels_Main_Pathway -0,05381 0,047212 0,052575 -0,42169 0,134511 0,32101 -0,09361 -0,23628 0,068148 -0,11964 0,601896 0,318174 0,246963 -0,049 0,20869 -0,21555 -0,35087 -0,76573 0,470336 0,63309 reactome_Regulation_of_Complement_cascade_M0,145165 0,367471 0,622921 -2,56938 -2,87359 -2,33437 -1,69397 -1,42693 -1,09103 -0,21698 -0,52645 0,501694 0,104394 0,156947 -0,46427 -2,40616 -3,22989 -2,17639 0,470499 0,63309 NCI_Glypican_3_network_Pathway_(embryonic_d -0,09564 0,050286 0,116565 -0,36742 0,244294 -0,31213 0,097088 0,003265 0,054753 0,191529 -0,01316 -0,25229 0,381473 0,174696 -0,05115 0,670257 0,045506 0,440729 0,471805 0,633753 NCI_Glypican_3_network_Pathway_(kidney_deve -0,09564 0,050286 0,116565 -0,36742 0,244294 -0,31213 0,097088 0,003265 0,054753 0,191529 -0,01316 -0,25229 0,381473 0,174696 -0,05115 0,670257 0,045506 0,440729 0,471805 0,633753 NCI_Glypican_3_network_Pathway_(skeletal_syst -0,09564 0,050286 0,116565 -0,36742 0,244294 -0,31213 0,097088 0,003265 0,054753 0,191529 -0,01316 -0,25229 0,381473 0,174696 -0,05115 0,670257 0,045506 0,440729 0,471805 0,633753 reactome_CTLA4_inhibitory_signaling_Main_Path 0,073641 -0,25112 -0,08744 -0,48234 -0,53434 -0,16299 -0,45346 -0,53823 -1,1442 0,514065 1,038712 0,7697 0,221077 0,235155 0,095709 -3,13584 -1,68442 -1,36963 0,471378 0,633753 reactome_Initial_triggering_of_complement_Mai -0,13397 0,082808 -0,16153 0,178132 0,20286 0,01815 -0,56955 -0,74734 -0,22441 0,42437 -0,75205 0,375152 0,440306 0,623486 0,10591 1,78825 1,165111 1,575867 0,474151 0,63663 dopamine_degradation 0,068636 -0,16555 0,059843 -0,78245 -0,33217 -0,58826 -1,21356 -1,2764 -1,24508 -0,68889 -0,45277 -0,37161 0,235022 -0,12144 0,161086 0,241754 0,1427 0,388288 0,474566 0,636638 KEGG_NOD_like_receptor_signaling_Main_Pathw 0,84705 -0,36743 -0,10866 -1,94354 -1,86382 -2,76312 -0,68627 0,373664 -1,84245 0,135087 -1,80878 -2,24176 0,226224 -0,05249 0,808026 -4,50052 -3,65317 -2,28169 0,474524 0,636638 reactome_Peptide_chain_elongation_Main_Pathw 2,872186 0,877569 0,446202 -9,22306 -10,6584 -13,0129 8,145455 9,28722 5,316214 -3,43894 6,752694 4,943317 -2,15478 -1,37583 0,805859 -44,2082 -37,5552 -32,3806 0,474844 0,636737 reactome_Mineralocorticoid_biosynthesis_Main_ -0,35106 -0,18147 -0,02751 0,393834 0,160578 0,610189 0,20221 -0,13691 0,478188 -0,76087 -0,02989 0,096198 0,073199 -0,33269 0,087962 2,046671 1,669994 1,418407 0,476239 0,638333 BRCA1_Pathway_Transciption_Coupled_Repair 0,019517 -0,01324 -0,08129 -0,04403 0,07153 -0,37691 0,191092 0,477369 -0,1431 0,618715 -0,01455 0,102054 -0,13278 -0,13398 -0,07336 -1,42468 -0,75902 -0,94882 0,476625 0,638574 biocarta_bcr_signaling_Main_Pathway -0,11711 -0,50485 -0,42662 0,685314 -0,53849 -0,64285 -0,72271 -0,70554 -0,9316 0,088365 0,468598 -1,20575 -1,19921 -1,91885 -0,6583 -1,55646 -0,60267 0,210764 0,477354 0,63904 NCI_Signaling_events_mediated_by_focal_adhesi 0,100812 -0,05437 0,049122 -0,179 0,406458 -0,42954 -1,85803 -1,45639 -2,30857 -0,4176 0,334054 0,544426 0,726669 0,442341 0,752874 -0,82972 0,330458 0,812965 0,477383 0,63904 reactome_Acyl_chain_remodelling_of_PS_Main_P -0,04972 0,092284 0,031767 -0,80579 -1,76859 -1,52183 0,492196 0,559474 0,929497 -1,12011 -1,3748 -0,6022 -0,29447 -0,32302 0,079884 -0,87114 -0,15523 -0,56881 0,477732 0,639233 NCI_Arf1_Pathway_(actin_filament_polymerizatio 0,013368 0,059741 -0,03857 -0,08206 -0,47565 -0,10475 0,064154 0,017492 -0,11506 -0,79293 -0,16869 0,13735 -0,30375 -0,2725 -0,28321 -1,11544 -0,9805 -0,53418 0,478903 0,64025 reactome_Formation_of_annular_gap_junctions_ -0,02955 0,055892 0,031077 -0,09992 -0,22125 -0,28727 -2,22665 -2,14269 -2,23734 -0,89234 0,857861 -0,06287 -0,05827 0,00128 0,239721 -0,04764 0,166692 0,41617 0,478861 0,64025 IP3_Pathway -1,60914 -2,22358 -1,366 1,268519 4,497615 2,175773 -7,70171 -9,55122 -5,85261 -5,29708 0,598579 -7,32458 0,927062 -0,95205 2,677923 5,31592 5,190133 9,633287 0,479925 0,641341 pentose_phosphate_pathway 0,170388 -0,13995 -0,03212 0,036373 -1,10675 -1,58817 -0,39849 -0,38781 -0,70252 0,129104 -0,0159 -0,3071 -0,12875 -0,02786 0,039056 -2,68828 -1,91688 -2,5957 0,481566 0,642982 reactome_Electric_Transmission_Across_Gap_Jun -0,16267 -0,16065 -0,16141 -0,20393 1,085205 -0,15477 0,530466 0,273953 0,670602 -0,55324 -0,1841 0,892738 0,219192 0,157511 0,31451 0,104908 0,430303 0,353645 0,481525 0,642982 reactome_DAG_and_IP3_signaling_Main_Pathwa 0,096089 -0,06991 0,08693 0,21806 0,665528 0,232076 -0,16536 -0,22872 -0,29028 0,36162 0,201561 -0,71494 0,044071 0,037618 -0,10578 0,111858 0,431011 0,119776 0,482186 0,643535 NCI_Signaling_events_mediated_by_VEGFR1_and 0,065182 0,030212 -0,07479 0,104897 0,14993 0,440972 -1,84925 -1,63706 -1,95728 -0,46969 -0,27572 -1,07125 -0,28404 -0,37247 -0,19174 -0,215 0,01765 0,515494 0,484484 0,646325 reactome_Activation_of_IRF3_IRF7_mediated_by 0,266661 -0,03842 -0,01413 -0,61258 -0,32011 -0,69939 -0,16937 -0,01298 -0,32942 0,276926 0,449253 -0,70318 -0,26761 -0,22798 0,022724 -2,41966 -1,86277 -1,53449 0,485801 0,647804 biocarta_tumor_suppressor_arf_inhibits_ribosom -0,11692 -0,09339 -0,11663 0,167068 -0,23515 -0,049 -0,02548 -0,02949 0,139012 -0,12623 0,172584 0,160989 -0,05458 -0,2383 -0,30572 -0,12321 -0,16571 -0,12005 0,48765 0,649991 pyrimidine_deoxyribonucleosides_degradation -0,26459 -0,09431 -0,05784 -0,38094 0,059393 -0,33471 -0,96479 -1,05331 -0,6819 -0,40012 -0,89477 -0,50488 -0,20008 -0,42482 -0,1005 0,313484 0,718233 0,268144 0,4879 0,650046 HGF_Pathway -0,83532 -1,38629 -1,03112 -3,98338 -2,8116 -3,4002 -8,40604 -6,8546 -9,94973 0,306034 1,260584 3,867514 0,040403 0,936765 1,921076 -11,6967 -8,11595 -5,74977 0,488589 0,650686 NCI_JNK_signaling_in_the_CD4_TCR_Main_Pathw -0,00989 -0,0802 0,033003 -0,48423 -0,15849 -0,29254 -0,095 -0,21042 -0,3668 -0,9757 -0,21867 0,262316 0,318654 0,663666 0,941777 1,332671 1,992709 1,754255 0,489034 0,651 4-aminobutyrate_degradation 0,046683 -0,08593 -0,05855 0,278393 0,076622 -0,52924 0,680638 0,719311 0,523431 -0,0419 0,113437 -0,73935 0,438174 0,114114 0,285854 -0,04835 0,182526 0,49234 0,489625 0,6515 WNT_Pathway_NFAT_Pathway 0,050676 -0,12923 -0,22209 0,692382 0,628583 -0,04877 -0,69719 -0,38512 -0,92569 -1,4764 0,035469 -1,0485 0,239394 0,264577 0,951747 0,382367 1,267979 2,51144 0,489827 0,6515 biocarta_tumor_suppressor_arf_inhibits_ribosom -0,11049 -0,09481 -0,22338 -0,14062 -0,4149 -0,12798 0,18829 0,282509 0,183966 -0,06569 0,232173 0,054687 -0,15527 -0,26832 -0,27382 -1,3285 -1,03712 -0,68211 0,490223 0,651684 KEGG_Central_carbon_metabolism_in_cancer_M -0,58626 -0,47555 -0,91443 -4,2503 -2,84384 -5,20863 -4,99467 -5,50646 -5,68547 -3,17897 -0,8803 0,358913 1,825306 0,965226 1,396584 -6,86566 -6,51336 -3,13543 0,490385 0,651684 KEGG_Hippo_signaling_Main_Pathway 1,955779 1,664995 0,59274 0,506378 0,392773 1,380325 -0,4104 0,100667 -2,75471 5,583295 2,892488 1,382185 -0,27743 -1,77358 0,586105 -9,5542 -7,77442 -7,85791 0,490877 0,652061 biocarta_tnf_stress_related_signaling_Main_Path 0,233549 -0,21755 -0,33624 -0,89866 -0,84444 -2,2382 -0,49928 -0,01472 -1,07362 -0,50788 0,151444 -0,26002 0,183607 0,926618 0,570897 -2,95941 -1,3865 -2,019 0,491285 0,652325 2-oxoglutarate_decarboxylation_to_succinyl-CoA 0,102695 -0,01876 0,018236 -0,23614 -0,08247 -0,3142 0,300388 0,390048 0,183272 -0,47587 0,660612 0,687989 -0,2432 -0,11317 -0,10995 -0,47196 -0,54186 -0,53156 0,492415 0,653444 NCI_Atypical_NF_kappaB_Main_Pathway -0,27282 -0,1618 -0,15991 -0,60029 1,254092 -0,8016 -0,58219 -0,60602 -0,59391 -0,23535 -1,58103 0,265451 0,290859 -0,06046 0,414693 0,295327 -0,04962 0,321371 0,492548 0,653444 KEGG_Complement_and_coagulation_cascades_M0,121567 0,29015 -0,08277 2,50861 2,76315 3,692108 -0,00766 -0,39403 0,797563 0,566991 -1,40236 1,101722 -0,93094 -0,26104 -1,5316 6,400319 5,465094 5,304257 0,492938 0,653683 reactome_Integration_of_energy_metabolism_M 0,091951 -0,05818 -0,03959 -0,43449 -0,58343 -0,61321 -0,04204 0,022663 -0,20059 0,47543 1,216118 0,630704 0,012803 0,026298 0,009609 -1,14956 -0,96147 -0,73528 0,493902 0,654683 KEGG_Glutathione_metabolism_Main_Pathway -0,55107 0,300298 0,026093 -3,29502 -2,27727 -2,9355 1,765107 1,803834 1,133167 2,98028 1,581835 4,324166 -0,20793 0,41669 0,976996 -3,95446 -4,59167 -3,06981 0,495002 0,655862 TRAF_Pathway -0,00198 -1,30389 -0,44552 -3,35655 -0,66022 -2,98593 -5,8185 -4,50662 -5,49918 6,419423 0,334114 4,825085 0,826397 -0,30689 0,565061 -3,53912 -4,33739 -2,02046 0,495869 0,656731 RANK_Signaling_in_Osteoclasts_Pathway_Express -0,15083 -0,44288 -0,7003 -0,40814 -2,02395 -0,55366 -1,23546 -0,79514 -1,65036 0,360675 -0,77913 -1,00227 0,681169 0,376074 1,422103 -0,75203 -1,31099 0,584683 0,496203 0,656894 biocarta_reversal_of_insulin_resistance_by_leptin -0,09535 -0,24263 -0,29696 -2,10342 -1,19746 -2,31189 -0,83854 -0,62462 -1,20142 -1,15895 -0,70476 -0,71598 0,079805 0,095798 0,229974 -3,56977 -2,37777 -2,61832 0,497687 0,6583 biocarta_reversal_of_insulin_resistance_by_leptin -0,09535 -0,24263 -0,29696 -2,10342 -1,19746 -2,31189 -0,83854 -0,62462 -1,20142 -1,15895 -0,70476 -0,71598 0,079805 0,095798 0,229974 -3,56977 -2,37777 -2,61832 0,497687 0,6583 reactome_Nectin_Necl_trans_heterodimerization -0,14617 -0,01754 -0,05657 0,822964 0,470103 0,505821 -0,41409 -0,51086 -0,42489 0,974151 0,411943 1,369046 -0,19524 -0,25431 0,009751 0,398851 0,255551 0,374255 0,498984 0,659735 NCI_Stabilization_and_expansion_of_the_E_cadh 0,046529 0,102039 0,117803 -0,26563 -0,1407 -0,41754 -0,7559 -0,70353 -0,94634 0,388519 0,605784 0,933206 -0,41767 -0,05513 0,021354 -2,71876 -2,31974 -2,08441 0,49956 0,659775 reactome_ATM_mediated_phosphorylation_of_re 0,047769 -0,18543 -0,17435 -0,01047 0,609617 0,121866 0,910323 1,090237 0,485639 -0,41402 0,171274 0,360468 -0,30666 -0,44804 -0,34665 -1,01972 -0,33493 -0,33224 0,49965 0,659775 reactome_Toxicity_of_botulinum_toxin_type_A_B -0,15435 0,104159 0,031064 0,112453 0,056152 -0,4583 -0,6348 -0,75563 -0,63371 -1,29365 -0,66638 -1,26657 0,45184 0,452798 0,32195 2,47556 2,930688 3,074054 0,499475 0,659775 fatty_acid_beta-oxidation_peroxisome 0,110519 -0,01843 0,403637 -0,97368 -0,42395 -1,03323 0,033582 0,044684 -0,42395 2,73143 2,679004 3,106168 0,377685 -0,06891 -0,26954 -3,36279 -1,86898 -2,26245 0,502719 0,662881 putrescine_biosynthesis_II -0,11537 0,038019 -0,0873 -0,47217 0,188031 0,38661 -0,06963 -0,13637 0,027897 0,683381 0,100013 -0,00675 -0,11875 0,143326 0,098293 0,203843 0,108007 0,334671 0,503066 0,662881 reactome_FasL_CD95L_signaling_Main_Pathway -0,00428 0,076991 0,024974 -0,29862 0,196212 0,373143 -0,28453 -0,2078 -0,09995 -0,37241 -0,24225 0,370227 0,048573 -0,14843 -0,27232 -0,72102 -0,17169 -0,0508 0,502289 0,662881 reactome_Regulation_of_signaling_by_CBL_Main_ 0,032354 -0,07409 -0,07265 0,784039 0,304422 0,249864 -0,4119 -0,74197 -0,53396 -0,49564 0,255703 1,07637 -0,54469 -0,23676 -0,06914 -0,36983 -0,6159 -0,62917 0,50292 0,662881 thioredoxin_pathway 0,060684 0,131967 -0,00908 0,11519 0,542134 0,280389 -0,38855 -0,12837 -0,21435 -1,47848 -0,03104 -0,11814 -0,39355 -0,99825 -0,64329 -0,66227 -0,88039 -0,54463 0,502838 0,662881 glycoaminoglycan-protein_linkage_region_biosynt -0,23001 -0,20977 -0,27629 0,560514 0,03112 0,653289 0,709022 0,693291 0,639933 -0,83288 -0,65256 0,168804 0,149075 -0,10684 0,182781 0,954776 1,319381 0,309819 0,504163 0,664046 biocarta_chaperones_modulate_interferon_signa -0,10075 -0,07716 -0,0538 -0,11927 -0,2591 0,061067 -0,12856 -0,07175 -0,11773 0,315452 0,508115 -0,02106 0,004917 -0,21165 0,032553 -0,29634 -0,17476 -0,20507 0,505186 0,664269 cAMP_Pathway_Cell_Proliferation -0,05174 0,042864 0,050458 0,052476 0,736511 0,528257 -1,08243 -0,94177 -1,08579 -0,85076 0,067722 0,630973 -0,74351 -0,38257 -0,30094 -0,72556 -0,78381 -0,31671 0,504995 0,664269 KEGG_Butanoate_metabolism_Main_Pathway 0,06691 -0,06287 0,118679 -0,22424 0,549608 -0,67663 1,026753 0,940413 0,999536 1,200249 1,1014 2,222818 0,681129 0,287341 -0,37428 -2,90725 -2,98009 -2,67544 0,504862 0,664269 reactome_Synthesis_of_IP2_IP_and_Ins_in_the_c 0,242269 -0,09139 0,077735 -0,65303 -0,59805 -1,22599 -1,66758 -1,6872 -2,2112 -1,60272 -1,22927 -3,29756 -0,97653 -0,77913 -0,67992 -1,56096 -1,15189 -1,10577 0,505162 0,664269 reactome_Interferon_alpha_beta_signaling_Main 0,818073 0,212528 0,880694 -1,00672 0,393881 -2,53593 0,645153 0,587761 0,957003 1,271641 2,672988 2,748433 1,916598 1,975271 3,392083 2,038349 1,881565 -0,25107 0,505412 0,664287 lysine_degradation_II_pipecolate_pathway 0,079131 -0,07083 -0,00358 -0,63817 -1,15713 -1,32846 0,262391 0,358457 0,21235 -0,3942 0,074715 -1,0221 0,679389 0,662998 0,517611 -1,55586 -1,30959 -0,4255 0,506947 0,665754 reactome_Biotin_transport_and_metabolism_Ma 0,441915 0,14768 0,063331 -0,05471 -1,04645 -0,64925 0,752554 0,9844 0,047676 1,392635 2,189091 0,982878 0,147082 0,09736 0,316574 -4,48728 -3,75703 -4,36348 0,50717 0,665754 reactome_Ficolins_bind_to_repetitive_carbohydr -0,08034 -0,06252 0,023146 0,585216 0,413435 0,847361 0,233322 0,056371 0,536358 -2,0718 -0,99788 0,376071 0,295989 -0,15445 -0,1843 1,67245 0,699892 0,709255 0,507109 0,665754 reactome_CD28_dependent_Vav1_Main_Pathway -0,16932 -0,21207 0,069832 -1,99656 -0,75154 -0,08723 -0,43435 -0,20761 -0,65733 0,783743 -1,34753 -0,22054 0,099223 0,568299 0,700224 0,363568 0,5464 0,902171 0,50826 0,666903 reactome_NF_kB_activation_through_FADD_RIP_ 0,156011 -0,08465 0,04097 0,033291 -0,16772 0,500482 -0,39233 -0,13197 -0,49098 0,134626 -0,35687 0,254634 -0,04552 -0,48288 -0,27957 0,06929 0,07369 -0,01924 0,509314 0,668005 biocarta_induction_of_apoptosis_through_dr3_an -0,00418 -0,3078 -0,19881 -0,89795 -0,88674 -2,29705 -1,93805 -1,63733 -1,7525 0,897178 0,31851 1,725429 0,754346 0,363764 0,040366 -1,07976 -1,11431 -1,18142 0,509632 0,668142 reactome_Interconversion_of_2_oxoglutarate_an 0,09919 -0,26002 -0,15968 0,194775 0,648799 -0,15213 0,459594 0,39362 0,320513 0,974763 -0,49914 0,712332 -0,08988 -0,18748 -0,16881 0,220079 0,28684 0,241572 0,509889 0,668197 Akt_Signaling_Pathway_Glucose_Uptake -0,01978 -0,09067 -0,04947 -0,41573 0,280349 -0,29592 -0,87369 -0,81337 -0,94956 0,574536 0,540367 -0,05083 0,100137 -0,01001 0,088118 -0,30203 0,041425 -0,12834 0,510581 0,668823 NCI_Plexin_D1_Signaling_Pathway_(receptor_rec -0,14248 -0,19924 -0,22922 -0,82242 -0,49236 -0,69693 -0,043 0,036915 -0,03493 -0,28889 -0,10181 -0,67346 0,252568 0,467354 0,700887 0,923622 1,279216 0,645959 0,511015 0,66911 NCI_VEGFR3_signaling_in_lymphatic_endothelium -0,02506 -0,06407 0,09333 -0,31619 -0,2846 0,002644 -0,79383 -0,88383 -0,81262 0,297527 0,45762 -0,11781 0,292791 0,074172 -0,02303 -1,00049 -0,52389 -0,59641 0,511306 0,669185 reactome_Regulation_of_Rheb_GTPase_activity_ -0,01031 -0,13776 -0,12734 -1,5094 -0,9151 -2,02035 -0,81248 -0,58541 -1,01945 -1,6791 0,319584 -0,7724 0,127878 0,207668 0,172058 -2,74722 -2,02121 -2,03407 0,511502 0,669185 NCI_IL2_signaling_events_mediated_by_PI3K_Pat 0,084374 0,288077 0,023408 -0,78935 0,471391 -0,92238 -0,27327 -0,44203 -0,43382 0,109064 0,33877 0,706652 0,276185 0,075946 0,349762 -2,85891 -1,24404 -0,97666 0,511822 0,669322 cardiolipin_biosynthesis -0,03124 -0,07674 -0,06222 -0,21843 -0,30496 -0,02691 0,181481 0,119015 0,087425 -0,67601 -0,43865 -0,12469 -0,29616 -0,22066 -0,09687 -0,10708 0,052227 0,382268 0,512125 0,669411 reactome_Tryptophan_catabolism_Main_Pathwa -0,02773 0,054479 0,209694 -0,66564 -1,18062 -0,42564 -1,79072 -2,23593 -1,72991 -1,12922 -1,15127 -1,48828 0,217054 -0,29676 -0,41269 0,467555 0,93974 -0,00256 0,512534 0,669411 reactome_Uptake_and_function_of_anthrax_toxi 0,023604 -0,05183 -0,05244 -0,24965 -0,22356 -0,47582 -0,44748 -0,38241 -0,6064 -1,39715 -0,0859 0,016515 0,059193 -0,038 0,161708 0,523084 0,309658 0,997898 0,512365 0,669411 reactome_Alternative_complement_activation_M -0,00062 0,212696 0,265274 -0,30443 0,388558 0,867423 0,183393 -0,10381 0,504467 -0,59157 -0,45558 0,327965 -0,40613 0,162226 -0,22195 1,165917 0,449628 1,047169 0,514955 0,67229 biocarta_il_6_signaling_Main_Pathway 0,154915 -0,15975 -0,15025 0,156404 -0,53505 -0,51481 -0,45441 -0,34495 -0,43438 0,440251 0,961385 0,037849 -0,31085 -0,29015 0,150088 -2,91362 -1,58056 -1,37298 0,516251 0,673136 GSK3_Signaling_Pathway 6,658664 4,011508 2,961412 4,46253 3,825608 7,119885 13,94227 15,78894 8,591739 -2,81557 7,691076 5,817254 -5,7759 -3,82123 -3,83185 -18,3526 -14,3514 -13,0464 0,516185 0,673136 TYROBP_Signaling_in_Natural_Killer_Cells -1,15186 -0,92138 -0,66795 -2,0038 -3,31652 -3,09637 -2,87211 -3,07865 -2,85852 -1,90433 2,478925 1,456152 -1,15927 -1,63226 0,304612 -11,6777 -9,16757 -4,98204 0,515889 0,673136 reactome_Bicarbonate_transporters_Main_Pathw -0,02594 0,07841 0,003602 -1,01312 0,479572 0,273077 -0,70474 -0,72685 -0,58039 -0,76624 -0,37699 -0,49855 -0,14854 0,14171 -0,1414 -0,25022 -0,24631 0,036629 0,51714 0,674013 reactome_N_Glycan_antennae_elongation_Main_ -0,1821 -0,48597 -0,22827 0,782583 0,501378 0,817152 -0,87232 -0,87379 -1,16243 0,422651 -0,06694 0,039349 -0,0125 -0,60967 -0,55794 1,571332 1,446792 1,070353 0,518036 0,674899 NCI_Alpha9_beta1_integrin_signaling_events_Pat -0,1565 -0,14316 -0,17631 -0,57347 0,429479 -0,93077 -1,76742 -1,81761 -1,86817 0,127904 -0,66069 -0,31005 0,697558 0,744002 0,763003 0,157712 0,453671 0,397993 0,519291 0,676251 NCI_CXCR4_mediated_signaling_events_Main_Pa -0,33251 -0,21042 0,000312 -2,35757 0,970408 -1,88816 -2,65989 -3,03672 -2,87911 1,637433 1,574825 2,444466 -0,23759 -0,50263 0,804815 -4,05778 -1,41977 0,610383 0,521474 0,67881 KEGG_Focal_adhesion_Main_Pathway -1,77832 -2,05141 -1,25906 -9,85132 -7,27988 -9,30246 -18,8203 -19,2141 -18,7404 3,217206 -1,03304 4,736308 3,595769 3,639657 3,232275 -3,43553 -2,11764 -2,3854 0,522215 0,679491 biocarta_role_of_erk5_in_neuronal_survival_Path 0,044318 -0,14509 -0,19402 -0,20183 0,36062 -0,4355 -0,7981 -0,62414 -1,19329 0,094376 0,904749 0,955697 0,079769 -0,12817 0,134779 -1,91842 -1,26612 -0,74729 0,52334 0,68067 NCI_Angiopoietin_receptor_Tie2_mediated_signa 0,086963 -0,14933 -0,19405 -0,81004 -0,36834 -0,49999 -2,45808 -2,63822 -2,55121 1,16426 -0,12691 -0,95972 0,30266 -0,20338 0,016482 -0,81537 -0,2394 0,448311 0,524912 0,68243 biocarta_no2_dependent_il_12_pathway_in_nk_c -0,03519 -0,0086 -0,02115 -0,12667 -0,13382 -0,30866 -0,20892 -0,25306 -0,26832 -0,20688 -0,21893 -0,08124 0,178424 0,124848 0,212112 -0,05273 0,00102 -0,00515 0,525225 0,682552 superpathway_of_steroid_hormone_biosynthesis -0,43981 -0,29536 0,161316 1,017536 -0,35918 0,329362 0,178544 -0,24109 1,123328 0,397329 -0,16482 -0,27216 -0,18806 -0,55064 0,413168 2,507993 1,218134 0,201232 0,525808 0,683025 biocarta_ifn_alpha_signaling_Main_Pathway 0,268786 -0,0552 -0,02528 -0,50346 -0,13148 -1,08266 -0,21923 -0,06089 -0,42428 0,17531 1,05619 0,8416 0,58286 0,522865 1,050039 -1,35697 -1,28835 -1,65898 0,526036 0,683036 fatty_acid_beta-oxidation 0,088404 0,009698 0,222742 -0,80679 -0,4141 -0,43663 0,691552 0,706622 0,13802 2,531883 1,965714 2,473428 0,675586 -0,2424 0,114515 -2,24435 -1,46198 -1,52338 0,526712 0,683629 reactome_Striated_Muscle_Contraction_Main_Pa -0,49964 -0,19127 0,250984 -0,23399 -0,21482 2,806673 0,539057 -0,43984 1,372715 0,217022 -0,69916 -1,14309 -0,01183 1,142945 0,518074 5,098225 4,053364 4,566361 0,527622 0,684524 NCI_IL8_and_CXCR1_mediated_signaling_events_ -0,03649 0,015265 0,011778 -0,30692 0,147266 -0,33764 -0,08386 -0,07468 0,005693 -0,69968 -0,49498 -0,64132 -0,13026 -0,00182 -0,06283 -0,13342 -0,08054 0,245342 0,528899 0,685895 Akt_Signaling_Pathway_p73_mediated_apoptosis 0,010476 -0,07313 0,334648 -1,17415 0,421112 -1,4118 -0,36669 -0,40636 -0,27585 -0,16318 0,604726 -0,83183 0,75163 0,654818 0,237733 -0,04772 1,012366 0,954396 0,530429 0,685977 glutathione_biosynthesis -0,01257 0,00886 -0,00168 -0,41123 -0,48552 -0,70881 -0,60321 -0,42422 -0,88843 0,611062 0,789799 0,39623 0,007433 0,191496 0,030527 -1,02439 -0,59688 -0,76369 0,529939 0,685977 L-cysteine_degradation_II -0,02936 -0,00997 -0,00895 0,15897 0,254525 0,006242 -0,0378 -0,09333 0,033402 0,426518 -0,06005 -0,00388 0,000102 0,027742 0,019416 0,034996 0,033486 -0,06515 0,530538 0,685977 MAPK_Signaling_Pathway -6,80919 -5,99578 -4,43045 -19,7009 -10,1841 -22,7258 -38,9731 -40,4393 -33,1089 -0,49252 -5,77168 -3,553 10,11477 6,10592 10,26762 9,550885 4,156786 13,7087 0,530698 0,685977 NCI_CDC42_signaling_events_Pathway_(cell_mot -0,23461 -0,12508 -0,36409 -0,51982 -0,29904 -0,36606 -1,12352 -0,96996 -1,11554 0,453412 0,391312 0,100821 0,256132 0,315995 0,222323 -0,06567 0,186942 0,111469 0,529433 0,685977 NCI_RAC1_signaling_Pathway_(neuron_projection 0,045068 -0,01957 0,053542 -0,6599 -0,35345 -0,00498 -0,24975 -0,1997 -0,41563 -0,66468 -0,68573 -0,32158 0,208199 0,237888 0,333188 0,611353 1,045518 1,187865 0,530724 0,685977 reactome_Cytosolic_sulfonation_of_small_molecu 0,038741 -0,04901 -0,12836 -0,51642 -0,04243 0,049314 0,059558 -0,13171 -0,04022 0,910464 -0,47294 0,302981 -0,5315 -0,83198 -0,35512 -1,15832 -0,41084 -0,93192 0,53054 0,685977 reactome_Proton_coupled_monocarboxylate_tra -0,01627 -0,10182 -0,03702 -0,15407 -0,0519 -0,39734 -1,05159 -1,2385 -0,93422 -1,1035 0,470759 0,289273 0,160124 0,210093 0,078754 0,359635 0,528718 0,515728 0,529253 0,685977 ILK_Signaling_Pathway_Cell_Motility -0,0901 -0,07853 -0,16414 -1,3353 -1,06894 -1,71404 -2,56454 -2,69402 -2,76901 -0,65437 0,55335 1,171042 0,932238 1,013571 0,756271 -2,77943 -2,00148 -2,00922 0,532325 0,687762 KEGG_PPAR_signaling_Main_Pathway -0,25062 0,019812 -0,18967 -0,94933 -0,18089 -0,01113 0,061186 0,023857 0,025183 -0,90618 -0,05442 0,107565 -0,10491 -0,03274 -0,12474 -0,09032 0,157761 0,157922 0,533207 0,688615 reactome_Sema4D_mediated_inhibition_of_cell_ -0,13814 -0,10641 -0,17413 -1,49171 -0,89641 -0,51889 -1,18337 -1,10051 -1,08468 0,03755 0,588163 -0,29726 0,128296 0,123378 -0,07117 -0,62191 -0,88385 -0,72052 0,533638 0,688886 acetone_degradation_I_to_methylglyoxal -0,07802 0,139541 -0,1929 -0,08696 0,196943 0,381492 0,580963 0,458638 0,652392 -1,37418 -0,56634 -1,25593 -0,07532 -0,08163 0,202854 1,024042 1,023689 0,350632 0,534961 0,690022 NCI_Beta5_beta6_beta7_and_beta8_integrin_cell -0,16659 -0,19704 -0,23329 -0,92568 -1,13467 -1,08659 -2,1925 -1,87659 -1,87347 -0,82904 -0,48442 1,08529 0,089734 0,144984 0,567421 -0,32261 -0,27407 -0,05974 0,534851 0,690022 NCI_E_cadherin_signaling_in_keratinocytes_Pathw -0,45935 -0,10809 -0,16992 -0,52904 0,003534 -0,49174 -0,96178 -0,99929 -0,86512 0,084758 1,243329 0,57038 -0,57466 0,166386 -0,18737 -1,19955 -0,03348 -0,79372 0,535814 0,690806 NCI_Reelin_signaling_Main_Pathway -0,00193 0,080517 -0,22262 -0,43484 -0,06466 -0,2011 -4,42681 -3,88098 -4,70392 0,744113 0,833905 0,834696 0,557328 0,284891 1,169957 -1,5065 -0,86789 0,035541 0,536012 0,690806 NCI_PAR1_mediated_thrombin_signaling_events_ -0,11592 -0,32241 -0,08943 0,067054 0,581531 -0,59125 -0,64513 -0,52223 -0,35751 0,172268 -1,06353 -1,06527 -0,28857 -0,39409 0,211902 1,129246 1,122652 1,754473 0,536286 0,690873 KEGG_Vitamin_B6_metabolism_Main_Pathway -0,11767 -0,08515 -0,06396 0,007542 0,973745 -0,04265 0,253476 0,277212 0,25142 0,131776 0,133459 -0,24664 0,046495 0,083863 -0,13733 0,390152 -0,15504 0,342525 0,53658 0,690966 reactome_TRP_channels_Main_Pathway -0,31 -0,34979 0,331879 -0,83584 1,435638 0,607454 -2,34473 -2,21914 -1,303 -1,56801 -1,53322 -2,99214 0,041599 -0,52845 0,499267 2,181744 1,779272 0,589496 0,53689 0,691079 NCI_Syndecan_2_mediated_signaling_events_Pat 0,00731 -0,09731 -0,0095 0,102484 0,111427 0,16386 -0,12144 -0,2069 0,057159 -0,1587 -0,32792 -0,97035 -0,41206 -0,26575 -0,31886 0,041611 -0,00356 -0,25816 0,537351 0,691387 reactome_Cobalamin_Cbl_vitamin_B12_transport 0,095916 0,357868 0,283348 -0,4007 -1,3352 0,008265 -0,34023 -0,26388 -0,68503 0,664905 0,852529 0,88905 -0,84467 -0,37552 0,111354 -2,09074 -1,55908 -1,27418 0,541307 0,69619 NCI_Wnt_signaling_network_Pathway_(Wnt_rece -0,92394 -0,47034 -0,26511 -0,28999 0,261627 -1,51399 -1,86735 -2,18149 -0,96868 -1,03727 0,50058 -0,87755 -0,47323 0,501403 0,271347 1,198415 1,035832 1,509195 0,542077 0,696892 KEGG_Thiamine_metabolism_Main_Pathway 0,047316 0,052564 -0,04732 0,223351 0,328043 0,142594 0,096915 0,251737 -0,12325 0,958885 0,909483 0,15558 -0,29538 -0,1649 -0,30959 0,001531 -0,14571 -0,83909 0,542322 0,69692 HGF_Pathway_Gene_Expression_via_JUN_STAT3_ -0,27251 -0,36667 -0,53554 -1,38345 -1,73917 -1,08985 -2,58445 -2,2137 -3,17138 -1,0588 0,267704 1,095077 0,319217 -0,07028 0,527091 -3,1186 -2,70586 -1,8462 0,543133 0,697674 biocarta_multiple_antiapoptotic_pathways_from_ 0,150085 -0,01062 -0,03922 0,2297 0,364195 -0,29795 -0,89046 -0,60374 -0,91282 0,177465 -0,59912 0,070672 -0,06126 -0,0177 -0,11797 -0,29985 -0,30041 0,240544 0,544154 0,697834 biocarta_multiple_antiapoptotic_pathways_from_ 0,150085 -0,01062 -0,03922 0,2297 0,364195 -0,29795 -0,89046 -0,60374 -0,91282 0,177465 -0,59912 0,070672 -0,06126 -0,0177 -0,11797 -0,29985 -0,30041 0,240544 0,544154 0,697834 Chemokine_Pathway_Cell_Activation 0,126553 -0,25089 -0,21403 -0,39348 -1,44821 -0,72037 -1,14318 -1,10396 -0,73382 -1,79936 -0,78239 -1,68101 -0,16558 0,196932 -0,24258 -1,08837 0,447666 -0,86538 0,543782 0,697834 reactome_Circadian_Clock_Main_Pathway 0,272658 0,023935 -0,10119 -1,14974 -1,9191 -2,79461 -0,3496 0,068307 -1,2395 -1,13993 -0,00848 -0,67003 -0,10506 -0,32197 0,437699 -5,2289 -4,26629 -2,36281 0,543809 0,697834 biocarta_fc_epsilon_receptor_i_signaling_in_mast 0,089319 0,042131 -0,08861 -0,77735 -0,04641 -1,44628 -0,70801 -0,62217 -0,90399 -0,28072 -0,2438 0,120677 -0,10152 -1,12439 0,289433 -3,27741 -2,46699 -1,54682 0,544391 0,697851 reactome_SIRT1_negatively_regulates_rRNA_Exp 0,112262 -0,13199 -0,53596 0,232124 -1,10536 -1,9621 4,864889 5,608581 3,61705 1,973936 1,423116 0,383223 -0,65657 -1,21539 0,716988 -6,73746 -4,3354 -4,22498 0,544628 0,697868 KEGG_Tuberculosis_Main_Pathway 0,738374 -0,15176 0,243137 -1,4688 -1,22372 -0,19369 1,697072 1,914979 0,939088 -2,26424 0,780718 -2,87378 -1,20508 -1,14856 -0,62786 -1,84042 -0,26323 -0,44834 0,545056 0,697873 oxidative_ethanol_degradation_III 0,310576 0,068512 0,171321 -0,14807 0,012842 0,493874 0,474391 0,640637 0,418878 0,695225 0,019823 1,168154 0,530492 0,418193 0,553093 -0,20112 -0,1488 -0,43758 0,545081 0,697873 phospholipases -0,42106 -0,48221 -0,53412 0,647803 -0,66427 -1,40773 -0,79751 -1,06742 0,080436 -1,79269 -1,98147 -1,44688 0,044876 -0,15439 0,243279 2,781852 3,909422 2,458585 0,545713 0,698397 NCI_mTOR_signaling_Pathway_(lipid_biosynthetic 0,019004 -0,02369 -0,11951 -0,37763 -0,30763 -1,05425 -1,383 -1,42505 -1,79102 0,423961 -0,28639 -0,82702 0,329653 0,428697 0,375142 -0,61008 -0,94169 -0,12819 0,546709 0,699383 IGF1R_Signaling_Pathway_Glucose_Uptake -0,19253 -0,03483 0,050324 -0,12722 -0,02075 -0,1444 0,144104 0,014571 0,221553 -0,02879 0,112733 -0,03478 0,097185 -0,1674 0,08283 0,058595 0,202037 -0,19246 0,548368 0,700642 NCI_Aurora_A_signaling_Pathway_(protein_catab -0,12239 0,06361 -0,0438 -0,27608 -0,24587 -0,01397 1,374186 1,365023 1,397794 -1,68614 -1,35694 -1,49714 -0,44579 -0,21551 -0,39831 -0,04305 0,50202 0,201158 0,548164 0,700642 reactome_CD28_co_stimulation_Main_Pathway -0,1728 -0,04707 0,033848 -1,03865 -0,35919 0,399728 -0,24493 -0,23308 -0,25414 0,757896 -0,72029 0,157298 -0,17046 0,214693 0,346905 0,080656 0,441678 0,029054 0,5482 0,700642 reactome_Inflammasomes_Main_Pathway -0,09059 0,01795 -0,04654 -0,74901 -0,1439 -0,36268 -0,34352 -0,29826 -0,40019 -0,14707 -0,86074 0,170219 0,237103 0,01174 0,158787 -0,36564 -0,64664 -0,34328 0,548648 0,700713 reactome_Urea_cycle_Main_Pathway 0,038715 -0,05321 0,006953 0,011189 -0,34286 0,236647 0,426244 0,283152 0,409322 0,330522 0,474984 0,575795 0,104274 0,227605 -0,45008 -0,8109 -1,84326 -0,60658 0,549695 0,701763 tetrapyrrole_biosynthesis -0,01261 -0,04675 -0,01487 0,159781 -0,21104 -0,0578 -0,33908 -0,35091 -0,25876 -0,30027 0,097185 0,461935 0,040635 -0,12789 0,272638 0,39875 0,151579 -0,02437 0,550068 0,70195 NCI_AP_1_transcription_factor_network_Main_P -0,57564 -0,45207 -0,54739 -0,17178 0,521236 0,072572 -1,90538 -1,86051 -1,99232 -0,61603 -0,19671 -0,47768 -0,01212 -0,01323 -0,01754 0,722719 0,466357 0,973175 0,550553 0,702282 NCI_Stabilization_and_expansion_of_the_E_cadh 0,145354 0,05927 0,042419 -0,47989 -0,04759 -0,1858 -0,46104 -0,56694 -0,69605 0,369308 1,424549 1,646949 -0,73661 -0,31212 -0,0762 -2,06939 -1,10016 -0,98368 0,550922 0,702314 sulfite_oxidation 0,053219 0,040356 0,043536 0,23213 -0,18973 -0,07933 -0,07681 -0,00314 -0,18341 -0,79353 0,017656 -0,04629 -0,21906 -0,07125 0,028201 -0,11462 -0,02048 -0,24816 0,551029 0,702314 NCI_Alpha_synuclein_signaling_Pathway_(cell_de -0,12522 -0,11284 0,080341 -0,0915 1,345872 0,319723 -1,3152 -1,50722 -1,18274 -0,58592 -0,14615 0,405755 0,110497 0,384995 0,895916 1,583574 0,216852 1,352638 0,552596 0,703735 NCI_Alpha_synuclein_signaling_Pathway_(proteas -0,12522 -0,11284 0,080341 -0,0915 1,345872 0,319723 -1,3152 -1,50722 -1,18274 -0,58592 -0,14615 0,405755 0,110497 0,384995 0,895916 1,583574 0,216852 1,352638 0,552596 0,703735 Circadian_Pathway 0,033012 0,157175 0,224939 0,270108 0,056276 1,411918 1,830898 1,69453 1,815529 0,307109 0,446123 -0,67334 -0,31274 -0,05603 -0,36537 -0,04985 -0,24004 -0,3344 0,552938 0,703883 reactome_Vpr_mediated_induction_of_apoptosis 0,030739 -0,0445 -0,05382 -0,12053 -0,60972 -0,13499 0,259015 0,266472 0,206225 -0,20248 0,262166 0,000704 -0,17196 -0,07141 -0,0096 -0,96415 -1,00053 -0,6788 0,554723 0,705867 biocarta_bcr_signaling_Pathway_(re_entry_into_m -0,09567 -0,2069 -0,12807 0,820755 -0,11815 -0,33892 0,420768 0,716903 0,402915 -0,16982 -0,27838 -1,40734 -0,67272 -0,93831 -0,13308 0,296807 0,651785 1,12275 0,555687 0,705868 biocarta_pten_dependent_cell_cycle_arrest_and_ -0,00794 -0,06417 -0,0714 0,514585 -0,68799 0,244645 -0,36519 -0,54534 -0,55541 0,417118 0,769224 0,770029 -0,10054 0,15947 0,037723 -0,32138 -0,24716 0,185686 0,555317 0,705868 ILK_Signaling_Pathway_Loss_of_Occludin_Barrier -0,23222 -0,33807 -0,08242 -1,19718 0,200851 -0,60831 -5,29841 -5,20163 -5,01564 1,317789 1,1357 2,304244 1,0691 0,819431 1,145962 -1,74911 -1,95805 -1,72387 0,555857 0,705868 NCI_Caspase_Cascade_in_Apoptosis_Main_Pathw -0,22961 -0,58544 -0,52401 -2,98965 -1,79742 -4,13196 -4,04965 -3,26528 -3,77345 1,929254 2,170691 2,091363 0,654528 0,809838 -0,1334 -4,67977 -3,35868 -1,86082 0,555549 0,705868 reactome_WNT5A_dependent_internalization_of_ -0,32363 -0,15881 -0,0783 -0,28483 0,164572 -1,26116 -0,27408 -0,45025 -0,47893 -1,4607 1,451295 1,761217 0,259273 0,343364 0,686147 0,215904 0,236498 0,531122 0,555498 0,705868 NCI_Presenilin_action_in_Notch_and_Wnt_signal 0,173865 0,338494 0,225487 0,391247 -0,1663 0,673762 0,199963 0,295214 0,317644 -0,02394 -0,10418 0,4862 -0,36091 0,076708 -0,09435 0,377554 -0,28142 0,599556 0,556432 0,70631 KEGG_MAPK_signaling_Main_Pathway -1,29431 -1,37332 -1,07585 -10,5534 -7,19018 -6,23279 -8,70662 -9,38525 -8,51113 -9,32744 -7,91834 -7,56081 2,86193 2,75307 3,623761 7,260361 8,54255 9,857581 0,557193 0,7067 KEGG_Melanogenesis_Main_Pathway -0,03045 -0,11996 -0,25527 -1,40445 -1,25169 -1,88518 -1,50943 -1,44423 -2,03002 -1,40015 -0,12754 -0,62049 -0,47384 -0,36084 -0,33729 -2,95032 -3,53079 -2,39364 0,557055 0,7067 lanosterol_biosynthesis 0,045093 0,01903 0,027197 -0,18336 0,006773 -0,11782 0,111393 0,175703 0,1163 -0,42456 -0,15565 -0,38882 0,119702 0,10405 -0,00318 0,216951 0,131959 -0,06039 0,55752 0,706827 KEGG_Amyotrophic_lateral_sclerosis_ALS__Main_ 0,188967 0,241347 0,061302 -0,31787 -0,80757 0,369591 1,476796 1,564133 1,469347 0,745047 0,37571 0,942721 -0,32956 -0,22054 -0,20217 -1,28732 -3,43437 -3,23956 0,560468 0,709699 Ras_Pathway_Golgi_Trafficking_and_Vesicle_Form -0,04734 -0,17106 -0,23306 0,289294 -0,01818 -0,49477 -0,90232 -0,62403 -1,26823 1,953054 0,275691 0,530795 0,022302 0,264117 0,008392 -1,88347 -1,42158 -1,06363 0,560076 0,709699 sphingomyelin_metabolismceramide_salvage 0,109473 0,114223 0,097865 -0,0359 -1,37118 -1,11288 0,066749 0,135165 -0,4066 0,875276 0,846784 -1,08615 -0,19151 -0,48624 -0,52874 -1,34412 -1,71172 -1,36499 0,560254 0,709699 NCI_Thromboxane_A2_receptor_signaling_Pathw -0,10044 0,026869 0,096643 -0,63683 -0,35528 -0,76875 -0,44352 -0,54896 -0,16621 -0,96365 -0,78624 -0,67265 -0,02245 0,101092 0,147152 0,485909 0,163055 0,813241 0,561863 0,71026 NCI_Thromboxane_A2_receptor_signaling_Pathw -0,10044 0,026869 0,096643 -0,63683 -0,35528 -0,76875 -0,44352 -0,54896 -0,16621 -0,96365 -0,78624 -0,67265 -0,02245 0,101092 0,147152 0,485909 0,163055 0,813241 0,561863 0,71026 putrescine_degradation_III 0,061893 -0,07787 -0,0522 -1,22271 -1,05841 -1,02796 -2,50257 -2,73359 -2,50899 -0,97049 -0,61706 -0,55747 0,742575 0,68832 0,667191 -0,66491 -1,04915 -0,23904 0,562052 0,71026 reactome_Amino_acid_synthesis_and_interconve 0,030041 -0,0538 -0,04195 -1,06149 -0,97288 -0,27345 0,493638 0,536903 0,410594 0,0168 1,104488 0,549008 -0,05495 0,050253 0,553746 -2,89245 -2,20966 -1,97478 0,561574 0,71026 SMAD_Signaling_Network_Pathway -3,40599 -2,91836 -3,09192 -1,24288 0,339776 -0,34527 -4,4869 -4,71336 -2,38428 -1,06106 -2,55566 -2,23944 3,241719 1,094502 0,762119 14,68339 9,655538 10,14249 0,561183 0,71026 methionine_salvage -0,02751 -0,07472 -0,01356 -0,81251 -1,04963 -0,60769 0,067135 -0,02063 0,125021 -0,56411 0,009744 -0,38304 0,02687 0,093009 0,201629 -0,3008 -0,34286 -0,27693 0,563724 0,712085 EGF_Pathway_Cell_Motility 0,022495 -0,02195 -0,03526 -0,65134 -0,22453 -0,7423 0,998872 1,117799 0,733035 -0,64571 -0,4313 -0,68695 0,068225 -0,17744 0,066938 -0,69593 -0,66427 -0,27385 0,564835 0,71291 reactome_Galactose_catabolism_Main_Pathway 0,002309 0,043821 0,157133 -0,48258 -0,39508 -0,38227 0,224604 0,145304 0,283585 -0,91083 -0,63197 -0,64812 -0,10033 -0,17271 0,247808 0,333003 0,543848 0,257785 0,564677 0,71291 biocarta_trefoil_factors_initiate_mucosal_healing 0,033625 -0,33434 -0,18325 -0,71313 -1,33749 -1,01907 -0,67364 -0,52337 -0,79147 0,38819 1,088928 0,335651 -0,28976 -0,76191 0,367466 -1,70554 -1,59634 -1,47274 0,565341 0,713259 cAMP_Pathway_Protein_Retention -0,0823 -0,03471 -0,05244 -0,57923 -0,16536 -0,88174 -0,56166 -0,32133 -0,7163 -0,38443 1,181281 1,414707 -0,99906 -0,67873 -0,31303 -2,36464 -1,83053 -0,95386 0,566747 0,714449 NCI_E_cadherin_signaling_in_keratinocytes_Pathw -0,2101 -0,11165 -0,01058 -0,57267 0,367669 -0,39233 -0,76246 -0,8871 -0,7066 0,489965 1,070728 1,478191 -0,37771 -0,09242 -0,02892 -1,42184 -0,44795 -0,73577 0,566525 0,714449 NCI_IL12_signaling_mediated_by_STAT4_Main_Pa -0,03077 -0,15026 -0,06016 -0,21357 -0,41977 -0,34918 -0,17228 0,000308 0,045785 -0,26019 -0,36873 0,319004 0,22214 0,301024 0,54371 0,897342 0,815618 0,133477 0,566972 0,714449 NCI_Endothelins_Pathway_(positive_regulation_o 0,08545 -0,07805 0,017792 0,220558 0,215286 -0,77727 -1,25436 -1,22944 -1,26633 0,842868 0,541276 -0,21952 0,130219 -0,1256 0,077267 -1,29112 -1,00046 -0,76956 0,567991 0,715155 reactome_Non_integrin_membrane_ECM_interac -0,07972 -0,27098 -0,12093 -0,65209 -1,30174 -0,52099 0,091229 0,135554 0,040982 0,069512 -0,19865 0,024861 0,565183 0,64525 0,670564 0,616318 0,448522 0,579727 0,567923 0,715155 ILK_Signaling_Pathway -6,6067 -4,46728 -3,93024 -17,7311 -9,43578 -16,5014 -31,7865 -34,6889 -25,3722 3,38641 -3,11181 -2,02187 11,26782 6,651601 8,319292 9,31385 3,064893 9,184732 0,568664 0,715713 VEGF_Pathway_Prostaglandin_Production -0,08809 0,011665 -0,01527 -0,69154 -1,63612 -1,93216 -0,51491 -0,18207 -1,0759 -1,40808 0,75616 -0,47847 0,489696 0,302632 0,594423 -2,41173 -1,80394 -1,95385 0,569164 0,716053 EGF_Pathway_Gene_Expression_via_FOS_NFKB2_ -0,35344 -0,44357 -0,43388 -2,60524 -1,12132 -2,25224 0,182414 0,869818 -0,33811 -1,10907 -1,13605 -2,55151 1,029517 0,210422 1,510094 -2,07872 -1,48749 0,62182 0,570859 0,717315 KEGG_Endocrine_and_other_factor_regulated_ca -0,48461 -0,16071 -0,32105 0,112244 0,121033 -0,5726 -1,24447 -1,22334 -0,30112 -0,70959 -0,30633 0,091988 0,453821 1,533083 2,195516 2,891312 3,815199 5,552473 0,570823 0,717315 reactome_Opsins_Main_Pathway -0,07485 -0,06437 0,16185 0,201878 0,489832 -0,28921 0,235494 0,310568 0,323701 -0,3103 0,156076 0,159837 0,54711 -0,25791 -0,05162 0,773695 0,439273 0,733501 0,570402 0,717315 NCI_IL2_mediated_signaling_events_Pathway_(G 0,001975 -0,15791 -0,11854 0,084717 -0,10877 -0,98764 -0,14173 -0,01583 -0,32408 0,167003 0,571919 0,710291 -0,24718 -0,25327 -0,05487 -0,74114 -0,96332 -0,54992 0,571537 0,717878 reactome_SEMA3A_Plexin_repulsion_signaling_b -0,23663 -0,22316 -0,40657 -1,01407 -0,40902 0,002169 -3,22768 -3,14785 -3,53294 -1,36864 -1,32835 -0,8183 0,212693 0,141529 -0,14479 0,259315 -0,25636 0,955606 0,571786 0,717901 reactome_Nef_Mediated_CD8_Down_regulation_ -0,01655 0,004823 0,086913 -0,24109 0,076905 0,150318 -0,43352 -0,34691 -0,50339 -0,33911 0,543028 0,185269 0,453234 0,097474 0,74801 0,073434 0,328903 0,204041 0,572024 0,717911 NCI_CXCR3_mediated_signaling_events_Pathway_ -0,35463 0,009199 0,217329 0,645857 0,392863 0,321194 -0,41843 -0,38111 -0,35462 1,327388 1,205994 -0,55052 -0,88128 -0,51554 0,262354 0,098197 0,941902 -0,73482 0,574488 0,718846 NCI_ErbB4_signaling_events_Pathway_(glial_cell_ -0,12579 0,03155 -0,05414 -1,22851 -1,25276 -1,85777 0,403185 0,478235 0,059656 -0,64784 -0,90357 -0,39226 0,579783 0,678195 0,55126 0,064025 0,218835 0,651453 0,573499 0,718846 NCI_Regulation_of_Telomerase_Pathway_(cell_cy 0,080179 0,185551 -0,02584 -0,15458 -0,25476 -0,48008 -0,14736 -0,25418 -0,29718 0,693182 -0,18268 0,003971 0,040173 -0,08015 -0,11577 -0,37143 -0,68577 -0,46915 0,575695 0,718846 p53_Signaling_Pathway_Breast_Cancer 0,002122 -0,20328 -0,12711 0,796829 0,160383 -0,3396 -1,02425 -0,55086 -1,83541 1,82264 2,077625 1,697306 0,76595 0,386345 0,62748 -1,70681 -1,21608 -1,44052 0,575769 0,718846 p53_Signaling_Pathway_Cell_Cycle_Arrest 0,002122 -0,20328 -0,12711 0,796829 0,160383 -0,3396 -1,02425 -0,55086 -1,83541 1,82264 2,077625 1,697306 0,76595 0,386345 0,62748 -1,70681 -1,21608 -1,44052 0,575769 0,718846 p53_Signaling_Pathway_Cell_Growth_Accumulati 0,002122 -0,20328 -0,12711 0,796829 0,160383 -0,3396 -1,02425 -0,55086 -1,83541 1,82264 2,077625 1,697306 0,76595 0,386345 0,62748 -1,70681 -1,21608 -1,44052 0,575769 0,718846 p53_Signaling_Pathway_DNA_Repair 0,002122 -0,20328 -0,12711 0,796829 0,160383 -0,3396 -1,02425 -0,55086 -1,83541 1,82264 2,077625 1,697306 0,76595 0,386345 0,62748 -1,70681 -1,21608 -1,44052 0,575769 0,718846 p53_Signaling_Pathway_Exosome_Mediated_Sec 0,002122 -0,20328 -0,12711 0,796829 0,160383 -0,3396 -1,02425 -0,55086 -1,83541 1,82264 2,077625 1,697306 0,76595 0,386345 0,62748 -1,70681 -1,21608 -1,44052 0,575769 0,718846 p53_Signaling_Pathway_Inhibition_of_Angiogene 0,002122 -0,20328 -0,12711 0,796829 0,160383 -0,3396 -1,02425 -0,55086 -1,83541 1,82264 2,077625 1,697306 0,76595 0,386345 0,62748 -1,70681 -1,21608 -1,44052 0,575769 0,718846 reactome_ERK_MAPK_targets_Main_Pathway 0,09277 -0,35681 -0,44569 -0,5266 -1,3082 -0,85738 -1,26869 -0,98074 -1,95583 -0,84599 1,957383 -0,09502 0,066556 0,464889 0,660029 -1,93413 -2,17476 -1,12732 0,57368 0,718846 reactome_misspliced_LRP5_mutants_have_enhan 0,190521 -0,13085 -0,05117 0,472073 0,012177 -0,31287 -0,14771 0,022438 -0,10248 -2,14929 -0,7593 -1,75717 -0,25006 -0,05546 0,278271 0,45874 0,969476 1,321524 0,575644 0,718846 reactome_RNF_mutants_show_enhanced_WNT_ 0,190521 -0,13085 -0,05117 0,472073 0,012177 -0,31287 -0,14771 0,022438 -0,10248 -2,14929 -0,7593 -1,75717 -0,25006 -0,05546 0,278271 0,45874 0,969476 1,321524 0,575644 0,718846 reactome_Signaling_by_Wnt_Main_Pathway 0,190521 -0,13085 -0,05117 0,472073 0,012177 -0,31287 -0,14771 0,022438 -0,10248 -2,14929 -0,7593 -1,75717 -0,25006 -0,05546 0,278271 0,45874 0,969476 1,321524 0,575644 0,718846 biocarta_acetylation_and_deacetylation_of_rela_ -0,10468 -0,13516 -0,14711 -0,39339 -0,16126 -0,04411 -1,11731 -1,00837 -1,31034 0,27248 -0,2199 0,515599 0,46843 -0,10523 0,379057 -0,26653 -0,49828 -0,07677 0,576433 0,719387 reactome_DAP12_signaling_Main_Pathway -0,30597 -0,06196 -0,2894 -1,50081 -0,69478 -1,96725 -1,11387 -1,1735 -1,4582 2,273034 1,616573 0,508717 -1,75158 -1,36318 -1,3203 -5,22638 -3,6494 -3,25867 0,577828 0,720839 biocarta_phospholipids_as_signalling_intermediar -0,17575 -0,81604 -0,4106 -1,73282 -2,63773 -3,11599 -3,25043 -2,56458 -3,79108 1,724508 0,784993 0,317319 -1,03921 -0,89445 0,032565 -5,31548 -3,94495 -1,64963 0,578076 0,72086 reactome_repression_of_WNT_target_genes_Ma 0,092634 0,037102 0,06006 0,111388 0,001623 0,085244 -0,30822 -0,1352 -0,4659 0,855936 -0,30997 0,495147 0,047121 0,107436 0,057178 -1,00934 -0,16098 -0,37294 0,578332 0,72089 Akt_Signaling_Pathway_Regulation_of_Cyclic_Nuc 0,03285 -0,13522 0,277562 -1,18523 0,296293 -1,31873 0,223522 0,305831 0,298558 0,412262 1,57892 -0,58313 0,786143 0,737605 0,397562 -0,55701 0,297924 0,56635 0,578807 0,721194 cAMP_Pathway_Fatty_Acid_Metabolism -0,40134 -0,45668 -0,3442 -0,27384 0,613656 0,373362 -2,20137 -2,77717 -0,62905 -2,99808 -1,78094 -0,32298 -1,37048 -0,69206 -1,01785 2,323833 2,548205 1,400272 0,57982 0,721522 NCI_Signaling_events_mediated_by_HDAC_Class_ -0,30115 -0,29057 -0,42453 0,396478 0,107342 -1,59728 -0,40159 -0,39104 -0,10779 -1,19696 -1,51011 -1,05764 0,159597 -0,45041 -0,18614 0,23913 -0,07147 0,37831 0,579369 0,721522 reactome_Packaging_Of_Telomere_Ends_Main_P 0,041543 -0,23419 -0,63588 0,730533 -0,53646 -1,52154 4,17154 4,789957 3,298244 2,37921 0,567706 0,0033 -0,46565 -0,74546 0,73349 -4,23832 -1,76844 -2,58864 0,579932 0,721522 triacylglycerol_biosynthesis -0,31117 -0,17237 -0,18134 -1,14691 -0,7208 -1,67885 0,227849 0,474193 -0,06018 -0,81093 -0,82197 -0,35151 0,380314 0,012637 0,881088 -1,31923 -1,09877 -0,54537 0,579997 0,721522 biocarta_ceramide_signaling_Main_Pathway 0,484218 0,008226 0,241854 -0,64034 -1,4499 -1,63268 -2,18455 -1,69242 -2,77607 -1,86405 -0,23836 -0,34441 -0,78281 -0,43295 -0,35015 -2,06974 -1,53009 -0,67421 0,580781 0,722208 reactome_Nef_and_signal_transduction_Main_Pa -0,01516 -0,04381 -0,05525 -1,62949 -0,90713 -1,2102 -0,20857 -0,11401 -0,32558 -0,89451 -0,45286 -0,88274 0,044523 0,384788 0,643805 -0,98828 -1,81421 -1,0829 0,581942 0,723363 KEGG_Sulfur_metabolism_Main_Pathway 0,303686 0,123135 0,127019 -0,16877 -0,45571 0,05091 -0,59363 -0,36623 -0,91402 -0,29146 0,30647 -0,28448 -0,81269 -0,69649 -0,5156 -2,52596 -2,07514 -1,57465 0,582623 0,723736 reactome_Ephrin_signaling_Main_Pathway -0,08487 -0,40147 -0,24121 -0,10947 -0,59033 0,310859 -2,37117 -2,12841 -2,83379 -0,94166 -0,42146 -1,56919 -0,08023 0,525514 0,25023 0,055744 0,716998 1,597073 0,582707 0,723736 mTOR_Pathway_Actin_Organization -0,21352 -0,12433 -0,22878 -0,87575 -0,27336 0,37921 -7,16485 -7,10534 -7,59781 0,556813 -0,71394 0,805018 0,976283 -0,03465 0,338213 -0,90519 -1,03775 0,843084 0,58356 0,724507 NCI_Presenilin_action_in_Notch_and_Wnt_signal 0,072218 0,064022 -0,19912 0,180393 0,101917 -0,29322 -0,36989 -0,18036 -0,81853 2,330054 0,15607 1,193423 0,018677 0,489525 0,772425 -0,13131 -0,81446 1,005226 0,584255 0,724792 RhoA_Signaling -0,26652 -0,32941 -0,35845 -2,21552 -2,48599 -3,18419 -1,50152 -1,71298 -2,64315 -0,78631 1,48865 -0,21711 -0,42387 0,169144 0,610761 -3,49639 -1,91549 -1,39451 0,584077 0,724792 reactome_ERKs_are_inactivated_Main_Pathway -0,11358 -0,40233 -0,32886 -1,09537 -1,50919 -1,90569 -1,05773 -0,81275 -1,28064 0,901543 1,366179 1,120367 0,134184 0,161399 0,438118 -2,06219 -1,61082 -1,58102 0,584902 0,725306 reactome_TRIF_mediated_programmed_cell_dea -0,0925 -0,0836 -0,05622 0,237008 -0,01763 0,090419 -0,53105 -0,41319 -0,5745 -0,32615 -0,09172 0,762234 -0,28002 -0,162 -0,17363 -0,49812 -0,29598 -0,53089 0,58523 0,725425 biocarta_induction_of_apoptosis_through_dr3_an -0,0416 -0,35721 -0,24597 -0,7861 -0,33879 -1,88061 -2,20821 -1,91316 -2,06611 1,016292 0,378549 1,979603 1,006518 0,507961 0,062252 -0,89224 -0,67032 -0,6774 0,585773 0,72552 reactome_MyD88_Mal_cascade_initiated_on_pla 0,225235 0,308246 0,001814 0,90144 0,764847 -1,28474 -1,06669 -0,99141 -1,44688 0,416136 0,564065 0,384135 0,167627 -0,17561 -0,11154 -1,62972 -1,19618 -0,79819 0,585633 0,72552 biocarta_regulation_of_spermatogenesis_by_crem -0,10063 0,33821 0,341554 -0,01853 -0,5411 -0,31128 0,505026 -0,02029 0,479145 1,190171 -0,01195 -1,13284 0,366995 0,629635 0,481249 -0,36162 -0,69688 -0,1161 0,588405 0,726788 GSK3_Signaling_Pathway_Glycogen_Synthesis 0,332835 0,246492 0,087324 -1,48413 0,088079 -0,12315 -0,61078 -0,72249 -0,70644 1,012069 -1,23454 1,961885 -0,76726 -0,28391 -0,0692 -1,72807 -1,62317 -0,62062 0,58843 0,726788 ICOS_signaling_in_T-helper_cells -0,05646 -0,03408 -0,1776 0,239178 0,385195 0,975253 0,618834 0,738456 0,621826 0,511318 -1,27622 -0,94382 -0,5282 -0,40421 -0,21001 -0,40959 0,808399 0,617737 0,587807 0,726788 KEGG_Type_II_diabetes_mellitus_Main_Pathway -0,09658 -0,06624 0,075041 -0,13302 0,029899 0,072355 0,060823 -0,01979 0,128151 -0,28036 0,0241 0,073519 -0,09267 -0,03379 0,121668 0,323515 0,242283 0,011356 0,587854 0,726788 NCI_Angiopoietin_receptor_Tie2_mediated_signa -0,02195 -0,20557 -0,04775 -0,78016 -1,10427 -1,42578 -0,73047 -0,72639 -0,8822 0,506138 -1,08136 -0,82567 0,414195 0,209478 0,39813 -0,31174 0,274696 0,198478 0,587151 0,726788 reactome_ERK1_activation_Main_Pathway 0,084899 -0,05694 -0,03793 -0,10243 -0,17158 -0,42081 0,309786 0,376958 0,178564 -0,27589 -0,00453 -0,31997 -0,15765 -0,19285 -0,2334 -0,65644 -0,25601 0,061823 0,588188 0,726788 reactome_Histamine_receptors_Main_Pathway -0,09202 0,029784 0,032379 0,083464 1,261815 0,71129 -0,59444 -0,89081 -0,25068 0,941689 -0,51569 0,947631 0,242115 -0,11693 0,032006 1,228687 1,455225 0,855624 0,588354 0,726788 ERK_Signaling_Pathway_EGFR_signaling 0,038768 0,151666 0,003391 -0,57761 -0,47682 -0,26006 -0,10303 -0,04044 -0,25171 -0,64443 0,592379 -0,07162 -0,37183 -0,27607 -0,45076 -1,01445 -1,16796 -0,50156 0,588763 0,726911 NCI_Degradation_of_beta_catenin_Main_Pathwa 0,319817 0,11254 -0,03519 -0,80404 -1,16917 -1,827 -0,75924 -0,70487 -1,20048 1,14288 0,271799 0,631653 -0,17535 0,226513 0,066899 -2,13073 -2,25681 -1,00548 0,589145 0,727095 KEGG_Acute_myeloid_leukemia_Main_Pathway -0,70195 -0,7746 -0,96133 -0,3433 -0,4065 -0,42701 -1,40265 -0,9154 -2,24704 3,02203 0,607853 1,280801 -0,31439 -0,32401 0,353509 -3,92795 -2,58349 -1,67564 0,591707 0,729968 NCI_Signaling_events_mediated_by_PTP1B_Main 0,222073 -0,12914 -0,08981 -0,23094 -0,18758 -0,61975 -1,24409 -1,53492 -1,63624 1,450363 0,341945 -0,11309 0,506333 -0,10361 0,327007 -2,06414 -0,95579 -0,95637 0,592032 0,730079 dermatan_sulfate_biosynthesis -0,16495 -0,1156 -0,1349 -0,48528 -0,63427 -0,31682 -0,19411 -0,18654 -0,56601 -0,8297 -0,78525 0,020735 0,22013 -0,12947 0,562778 0,648677 1,38094 0,254013 0,592452 0,730308 biocarta_control_of_skeletal_myogenesis_by_hda -0,14363 -0,11365 -0,04491 1,27218 0,857224 0,618958 -0,43189 -0,46212 -0,2788 -0,97738 -0,34239 -0,53023 -0,2418 -0,66167 -0,42998 0,638652 0,563198 1,154911 0,595694 0,731848 biocarta_role_of_pi3k_subunit_p85_in_regulation 0,102255 -0,21545 -0,17763 -1,52439 -2,17242 -1,03971 -1,48686 -1,20364 -2,19182 -1,5153 -0,25191 -0,28117 -0,37061 -0,121 -0,01803 -2,64518 -1,12298 0,59046 0,596342 0,731848 KEGG_Fc_epsilon_RI_signaling_Main_Pathway 0,120282 -0,31556 -0,44767 -0,87037 -0,97512 -2,78357 -1,02668 -0,89837 -1,67845 -0,83852 0,21305 0,644648 -0,22575 -0,53917 -0,10419 -5,94141 -3,40879 -2,30367 0,595051 0,731848 NCI_Stabilization_and_expansion_of_the_E_cadh -0,02284 0,022053 0,01243 -0,36335 -0,12465 -0,19493 -0,37972 -0,53371 -0,47982 0,445497 1,078515 1,441922 -0,54381 0,0135 -0,05367 -1,44396 -0,94919 -0,86486 0,594967 0,731848 PPAR_Pathway_Adipocyte_Differentiation_Glucos -0,11217 -0,03409 -0,06328 -1,21365 -0,90789 -0,59493 -0,4998 -0,47926 -0,7574 -0,42666 -0,12037 -0,73777 0,235449 0,151407 0,147823 -0,52835 -0,19495 0,323947 0,596755 0,731848 PPAR_Pathway_Fatty_Acid_Metabolism_Lipid_Ho -0,11217 -0,03409 -0,06328 -1,21365 -0,90789 -0,59493 -0,4998 -0,47926 -0,7574 -0,42666 -0,12037 -0,73777 0,235449 0,151407 0,147823 -0,52835 -0,19495 0,323947 0,596755 0,731848 PPAR_Pathway_Peroxisome_Proliferation_Hepato -0,11217 -0,03409 -0,06328 -1,21365 -0,90789 -0,59493 -0,4998 -0,47926 -0,7574 -0,42666 -0,12037 -0,73777 0,235449 0,151407 0,147823 -0,52835 -0,19495 0,323947 0,596755 0,731848 reactome_AUF1_hnRNP_D0_destabilizes_mRNA_ -0,05809 -0,18918 -0,07455 -0,74459 -0,64774 -0,03299 0,736293 0,767338 0,514654 -0,11118 0,57437 0,714834 -0,31454 -0,44046 -0,09898 -3,01234 -1,78043 -1,60796 0,595694 0,731848 reactome_G_alpha_z_signalling_events_Main_Pa -0,48253 -0,03807 -0,27415 -0,34699 0,74233 -0,21202 -1,98812 -2,40412 -1,6037 -1,67064 1,298867 -0,44971 -0,13805 0,272347 0,233818 1,25063 1,110271 2,2401 0,595088 0,731848 reactome_Glucocorticoid_biosynthesis_Main_Pat -0,46619 -0,31323 -0,08803 0,309593 0,107943 0,378483 0,364691 -0,38431 0,7792 -0,32758 -0,6421 -0,54746 0,0838 -0,23955 -0,18816 2,491162 1,402977 1,050727 0,596144 0,731848 reactome_MyD88_cascade_initiated_on_plasma_ 0,072749 0,120764 -0,05649 0,625968 0,17481 -0,43325 -1,21365 -1,23446 -1,45017 0,807725 0,792297 1,014848 0,048954 0,069496 0,057597 -1,48884 -1,07976 -1,01365 0,595224 0,731848 reactome_Vitamin_D_calciferol_metabolism_Mai -0,12021 0,013386 -0,01234 -0,90178 0,123749 0,833211 0,345054 0,094278 0,302127 0,989183 0,932163 0,480181 0,55888 0,099776 0,165991 -0,80854 -0,79209 -1,06522 0,595249 0,731848 reactome_XAV939_inhibits_tankyrase_stabilizing_ -0,16402 0,112043 0,018184 -0,53539 0,074445 0,624066 -0,01143 -0,08169 -0,20726 1,988395 0,851386 1,912982 0,035258 -0,28109 -0,44822 -0,86931 -1,11512 -1,34253 0,594833 0,731848 IL-10_Pathway -0,46506 -0,51914 -0,55391 -1,43953 -2,02243 -1,36499 -0,38135 0,537288 -0,41515 2,751876 0,393037 2,355642 1,036187 0,502261 1,043667 -5,58911 -3,73516 -3,28847 0,598215 0,733349 NCI_amb2_Integrin_signaling_Pathway_(dendritic -0,10322 -0,25283 -0,18097 0,459804 -0,19471 -0,04631 -0,75655 -0,89194 -0,1807 -0,8108 0,105535 -0,18359 0,632699 0,111276 0,669499 1,329784 0,526958 0,756613 0,59952 0,734082 NCI_amb2_Integrin_signaling_Pathway_(phagocyt -0,10322 -0,25283 -0,18097 0,459804 -0,19471 -0,04631 -0,75655 -0,89194 -0,1807 -0,8108 0,105535 -0,18359 0,632699 0,111276 0,669499 1,329784 0,526958 0,756613 0,59952 0,734082 superpathway_of_geranylgeranyldiphosphate_bio 0,119481 0,100859 0,005285 0,256494 0,285611 0,845046 1,430916 1,28988 1,253142 0,164926 1,573479 1,510718 -0,35154 -0,45725 -0,46418 -3,15878 -1,3719 -1,43069 0,599212 0,734082 biocarta_toll_like_receptor_Main_Pathway 0,000578 -0,19993 -0,3563 -0,14361 -0,38775 -1,17096 -1,8653 -1,31642 -2,77909 1,148704 2,284496 0,888183 -0,19984 -0,01709 0,06991 -1,19118 -1,54581 -1,51027 0,600129 0,734539 reactome_Assembly_of_the_RAD50_MRE11_NBS -0,02719 -0,09797 -0,11876 -0,33289 0,174612 -0,05047 0,120886 0,221118 -0,09142 -0,13187 0,184518 0,206236 -0,13988 -0,08073 -0,1268 -0,69978 -0,39078 -0,31884 0,600754 0,735015 biocarta_trka_receptor_signaling_Main_Pathway -0,07619 -0,29805 -0,19431 -1,0353 -0,03599 -0,61885 -0,81282 -0,92399 -0,88258 0,612222 0,581992 0,172387 0,499889 -0,13696 0,407426 -2,46304 -0,96213 -0,66264 0,601268 0,735067 pyrimidine_ribonucleosides_salvage_I 0,027957 -0,13295 -0,0864 -0,54125 0,083428 -0,70883 0,131422 0,184594 0,264344 -0,21441 -0,30348 -0,16112 0,010655 0,030763 -0,00344 -0,37435 -0,49232 -0,74268 0,601122 0,735067 NCI_Aurora_A_signaling_Pathway_(spindle_assem 0,010393 -0,02553 -0,11284 -0,40772 -1,09381 -0,27588 0,723694 0,77366 0,508713 -1,63525 -1,0715 -0,91282 -0,34179 -0,2825 -0,37031 -0,83142 -0,07549 -0,61058 0,603462 0,73746 KEGG_PI3K_Akt_signaling_Main_Pathway 0,903518 1,408698 0,755591 6,415484 3,120953 1,826702 8,985998 10,05889 7,824782 -4,68062 5,556302 5,138673 -1,36945 -2,18781 -1,16347 -4,85825 -1,9889 -1,0699 0,604434 0,738358 reactome_Methylation_Main_Pathway 0,177006 0,07942 0,05706 -1,27033 -0,36652 -0,07353 -0,17547 -0,21827 -0,33326 -0,17603 -0,30183 0,607188 -0,07372 0,116739 -0,41413 -1,10583 -0,73603 -0,45762 0,606002 0,739983 serine_biosynthesis_phosphorylated_route 0,10635 0,043867 -0,01706 -0,99295 -0,87853 -0,33853 0,88537 1,007443 0,737263 -0,84968 0,415628 -0,27751 -0,31842 -0,39517 -0,49435 -2,45627 -2,13322 -1,77656 0,607035 0,740954 reactome_Propionyl_CoA_catabolism_Main_Path 0,197085 0,153282 0,042013 -0,88839 -1,25624 -0,69842 0,077122 0,201654 -0,51224 -0,1286 0,416597 0,525404 -0,07544 -0,10379 0,176685 -3,02548 -2,46385 -2,53704 0,607789 0,741584 NCI_Signaling_events_mediated_by_HDAC_Class_ -0,10189 -0,02404 -0,10813 -0,16396 -0,46445 -0,80815 0,169584 0,121996 0,149004 -0,52442 -0,41794 -0,49036 -0,10209 -0,4047 -0,46095 -1,0722 -1,00876 -0,6289 0,608391 0,742028 KEGG_Estrogen_signaling_Main_Pathway -0,67063 -1,40838 -1,25425 -1,49428 1,216415 -2,13454 -4,96283 -4,82801 -5,59107 -2,50643 -0,71173 3,893521 1,459349 1,462583 2,462428 -1,38453 2,039504 1,617455 0,609544 0,742987 reactome_Transferrin_endocytosis_and_recycling -0,15407 -0,16245 0,056988 -1,89747 -3,61719 -1,35904 -2,80615 -2,52741 -3,42508 0,549733 -0,02397 -0,32687 -1,49501 -1,57666 -1,16968 -5,67071 -3,27664 -3,76335 0,609655 0,742987 reactome_Glucagon_like_Peptide_1_GLP1_regula -0,23826 -0,26953 -0,06781 1,486627 1,522813 -0,09443 -1,49185 -1,91101 -1,50852 -3,65566 -0,02429 0,301606 -1,80678 -1,32216 -0,58501 -0,29847 -0,71805 0,455937 0,611982 0,745531 ornithine_ide_novo_i_biosynthesis 0,021305 0,038576 2,83E-05 0,051572 -0,274 0,038291 0,317695 0,346438 0,220845 0,3194 -0,11095 0,2538 -0,23859 -0,24823 -0,1216 -0,74603 -0,93301 -0,84082 0,612625 0,746023 NCI_Integrin_linked_kinase_signaling_Pathway_(a -0,16813 -0,12788 -0,18112 0,279525 -0,01161 0,23963 -1,50354 -1,63746 -1,59857 0,571307 1,316377 0,784298 0,60695 0,520881 0,7095 -0,13021 0,062771 0,422598 0,613484 0,746213 NCI_Integrin_linked_kinase_signaling_Pathway_(a -0,16813 -0,12788 -0,18112 0,279525 -0,01161 0,23963 -1,50354 -1,63746 -1,59857 0,571307 1,316377 0,784298 0,60695 0,520881 0,7095 -0,13021 0,062771 0,422598 0,613484 0,746213 reactome_Transport_of_vitamins_nucleosides_an 0,047759 0,041881 -0,08647 0,830308 -0,53049 0,387082 -0,5206 -0,48844 -0,76684 0,147398 0,669818 0,771357 -0,12242 -0,30613 -0,14149 -0,87467 -0,91144 -1,03854 0,613499 0,746213 NCI_HIV_1_Nef_Negative_effector_of_Fas_and_T 0,197989 0,057376 0,075736 -0,41523 -0,18193 -0,3332 -2,03799 -1,67331 -2,41422 1,126003 -1,19702 1,07902 -0,2808 -0,40385 -0,46921 -3,52053 -2,27606 -1,12061 0,613913 0,746424 KEGG_Choline_metabolism_in_cancer_Main_Path -0,38013 -0,83727 -0,85264 -1,22574 -1,36514 -2,66288 -1,74523 -1,02986 -3,18278 1,127822 -1,04017 2,448732 -0,38275 0,044546 0,500631 -6,97075 -3,58576 -2,31353 0,614391 0,746714 reactome_Activation_of_BMF_and_translocation_ 0,03816 -0,03733 0,031562 0,12168 0,065031 0,009952 0,510299 0,481818 0,428289 -0,21732 0,0715 0,365355 0,176773 0,029741 0,209588 0,093436 0,392862 0,6059 0,61522 0,74743 iron-sulfur_cluster_biosynthesis 0,018233 0,044879 0,046721 -0,2951 -0,01356 0,109831 0,17018 0,199675 0,123228 0,387674 0,268449 0,268077 0,047097 -0,01233 0,086323 -0,10434 -0,27014 -0,31497 0,618945 0,748835 NCI_Netrin_mediated_signaling_events_Main_Pa -0,16516 -0,62376 -0,48195 -2,27116 -1,56762 -2,15897 -4,16173 -3,62181 -4,61884 -1,0811 0,09414 -0,61821 0,964528 1,088004 1,104127 -2,5715 -1,79356 -0,5181 0,618334 0,748835 p53_Signaling_Pathway_Apoptosis -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Cancer -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Gene_Expression_Anti-A -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Gene_Expression_Cell_C -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Gene_Expression_Cell_Fa -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Gene_Expression_Cell_S -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Gene_Expression_DNA_R -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Gene_Expression_ECM_a -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Gene_Expression_Infecti -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 p53_Signaling_Pathway_Normal_Cell_Cycle_Prog -0,12097 -0,25987 -0,3291 0,675005 0,240903 -0,03672 -0,76997 -0,20524 -1,52969 1,45799 2,156935 1,828928 0,911538 0,093616 0,491185 -1,57327 -0,96049 -0,79357 0,619261 0,748835 biocarta_igf_1_signaling_Main_Pathway 0,081745 -0,1099 -0,03551 -0,24891 -1,17102 -1,12514 -1,88762 -1,82302 -1,92951 1,449183 0,163455 0,533335 0,227117 0,138767 0,291861 -1,86318 -1,03586 -0,12658 0,620733 0,749873 bupropion_degradation -0,22725 0,341009 -0,03943 -0,59861 -0,05733 0,270805 0,054206 -0,13491 0,174936 -0,6212 -0,02832 0,167719 -0,31758 0,309383 -0,15952 0,593361 0,345999 -0,47191 0,621306 0,749873 NCI_Angiopoietin_receptor_Tie2_mediated_signa 0,126555 0,02643 -0,03029 -0,61686 0,4029 0,253471 0,124611 0,087487 -0,02781 -0,10579 0,402222 0,15015 0,01664 0,06247 -0,02559 -0,66151 -0,26027 -0,31607 0,621365 0,749873 NCI_Signaling_events_mediated_by_HDAC_Class_ -0,01501 -0,04324 -0,08943 -0,83259 -0,13196 -0,37609 -0,90687 -0,78106 -1,08019 0,151723 -0,73731 0,602405 0,351627 -0,11988 0,291343 -0,53315 -1,04024 -0,65473 0,621025 0,749873 reactome_Gamma_carboxylation_of_protein_pre -0,1029 -0,02214 0,057169 -0,99251 -0,1723 0,884897 -0,1628 -0,53607 0,340477 -1,24761 0,302466 0,866376 0,096148 -0,14699 0,263805 0,846238 0,687906 0,029835 0,621218 0,749873 reactome_Lysosome_Vesicle_Biogenesis_Main_Pa -0,15957 -0,17057 -0,25617 -1,85685 -1,76032 -1,50496 -3,77928 -3,68393 -4,20299 -0,84786 -0,39357 1,079804 0,123561 -0,37562 0,601563 -1,8098 -1,52536 -0,71456 0,621564 0,749873 KEGG_Bile_secretion_Main_Pathway -0,04951 0,056088 -0,00359 -0,60121 0,260221 -0,10856 0,199697 0,126927 0,300976 -0,34431 -0,29597 0,311321 0,179134 -0,19894 -0,1353 -0,30183 0,252301 0,155338 0,621928 0,750022 NCI_Visual_signal_transduction_Rods_Main_Path 0,0537 0,107962 0,05808 0,401493 1,21075 -0,32744 0,346178 -0,13122 0,87937 0,610781 0,612098 -0,2069 0,430313 0,013337 -0,11942 1,276829 0,025382 1,170902 0,625002 0,753436 NCI_ErbB1_downstream_signaling_Main_Pathwa 0,631368 0,14712 0,065424 -1,17105 -4,89524 -5,88666 1,021056 1,720683 -0,28347 -4,84118 -0,78003 -2,69191 -1,08336 -1,33775 -0,6615 -9,20137 -7,45673 -5,22215 0,626503 0,754955 FCGR3A-mediated_phagocytosis 0,123452 -0,32047 -0,21579 -1,14019 -1,34981 -0,03574 -0,17677 -0,51641 -0,20892 -1,03827 -0,87302 1,129178 -0,40414 -0,29906 0,12831 -2,20053 -1,97513 -1,17059 0,628616 0,756747 NCI_ErbB4_signaling_events_Pathway_(cell_prolif -0,12918 -0,00534 -0,05438 -1,54786 -1,06766 -1,83468 -0,11035 -0,06957 -0,31378 -0,50257 -0,12917 -0,07916 0,403666 0,218138 0,303317 -1,02859 -0,81913 -0,55792 0,628674 0,756747 reactome_SHC1_events_in_ERBB2_signaling_Mai -0,11087 -0,21637 -0,14222 -1,4687 -1,05355 -1,96068 -0,12535 -0,10821 -0,44927 -0,82004 0,089199 -1,07408 0,257898 0,284016 0,284193 -2,30437 -1,80769 -1,34273 0,62872 0,756747 reactome_HDL_mediated_lipid_transport_Main_P -0,48609 0,117345 0,201087 0,29372 0,093602 0,374168 -1,51125 -1,86894 -0,93565 0,314767 -0,19539 -0,55529 0,781159 0,290891 0,446902 1,478986 0,903365 0,576357 0,629342 0,757204 biocarta_granzyme_a_mediated_apoptosis_Pathw -0,15006 0,026963 0,21395 0,624463 0,773234 0,222188 -0,07884 -0,03025 0,501357 -0,33381 -0,07338 -0,04189 0,22008 0,203487 0,341278 0,868308 1,259078 0,866549 0,629813 0,757478 Development_of_Immune_Synapse -1,19219 0,19307 -0,52738 0,822653 0,121287 1,901947 -4,31057 -5,19811 -2,41675 1,035908 2,60669 5,013015 -0,56288 -0,0715 0,79804 -4,97823 -1,17913 -0,86818 0,631374 0,759062 biocarta_atm_signaling_Pathway_(Pathway_prote 0,063316 -0,05724 -0,03537 0,352679 0,283079 0,185196 -0,25538 -0,03484 -0,37661 0,53346 0,791998 0,324583 -0,08712 -0,26299 -0,30675 -1,09471 -0,72244 -0,59974 0,632394 0,759288 KEGG_Lysosome_Main_Pathway -0,26072 -0,81567 -0,18491 -6,72753 -7,17717 -7,58512 -13,6725 -12,4997 -16,2526 -0,23693 -0,15331 3,162606 -0,2209 -0,8067 2,810525 -17,1295 -16,2436 -11,7391 0,632537 0,759288 NCI_Plexin_D1_Signaling_Pathway_(endothelial_c -0,0366 -0,204 -0,19421 -0,71451 -1,17038 -0,34519 0,500958 0,508574 0,326376 -0,21859 -0,00034 -0,34327 0,497132 0,502308 0,492657 0,479707 0,680207 0,170551 0,632148 0,759288 reactome_L1CAM_interactions_Main_Pathway -0,14755 -0,27037 -0,25975 -0,37425 -0,48211 -0,05053 -0,34197 -0,16486 -0,68787 -0,22271 -1,30032 -0,96798 0,167482 0,366364 0,806757 1,564441 1,970484 2,43823 0,632411 0,759288 NCI_Glypican_1_network_Main_Pathway -0,37168 0,083386 -0,42749 -1,37851 -2,2462 -1,84847 -3,37006 -3,59445 -3,37601 1,921494 -0,38732 -1,08291 0,348007 0,721759 0,686515 -1,2736 -0,48897 -0,73246 0,634561 0,761188 reactome_activated_TAK1_mediates_p38_MAPK_ 0,075652 -0,19273 -0,23964 -0,31997 -0,13144 -0,54312 0,257204 0,357891 0,100897 0,746484 1,093075 0,75603 0,345656 0,413473 0,492571 -0,27123 -0,10953 -0,35969 0,634609 0,761188 Akt_Signaling_Pathway_Splicing_Regulation -0,01036 -0,06515 -0,05249 0,048582 0,319241 -0,08904 -0,19425 -0,22173 -0,42724 0,248612 0,716443 0,029435 -0,19419 -0,07012 -0,18546 -0,34402 -0,15202 -0,07418 0,636923 0,76367 ethanol_degradation_IV 0,163077 0,100466 0,004052 -0,45362 -0,27125 -0,13975 0,24922 0,463226 0,130241 0,679079 0,012996 0,97398 0,252878 0,31762 0,389839 -0,95345 -1,16984 -0,91205 0,637359 0,763899 NCI_IL2_signaling_events_mediated_by_PI3K_Pat 0,032444 0,266721 0,038576 -1,51132 0,408819 -0,88735 -0,17425 -0,43271 -0,33262 0,444528 0,207798 0,26183 0,29214 -0,03843 0,302991 -2,76029 -1,54882 -1,20469 0,639288 0,765917 ATM_Pathway_G2-Mitosis_progression -0,14143 -0,1532 -0,14744 1,517868 1,030313 0,389133 -1,75301 -1,6652 -1,61431 2,414585 1,348778 1,456244 0,049684 0,144801 0,479996 0,888822 1,18879 0,194081 0,641086 0,767185 ATM_Pathway_G2_M_Checkpoint_Arrest -0,14143 -0,1532 -0,14744 1,517868 1,030313 0,389133 -1,75301 -1,6652 -1,61431 2,414585 1,348778 1,456244 0,049684 0,144801 0,479996 0,888822 1,18879 0,194081 0,641086 0,767185 creatine-phosphate_biosynthesis -0,07592 -0,04037 -0,00182 -0,79679 -0,9846 0,00175 1,158539 1,046613 1,088639 1,047636 0,363681 0,947942 0,341329 -0,04658 -0,13726 -0,89121 -0,93529 -1,35544 0,640727 0,767185 KEGG_Folate_biosynthesis_Main_Pathway -0,03504 0,154461 0,001925 -0,39116 -0,6948 -0,19589 -0,15407 -0,04538 -0,16594 -0,22541 1,060093 0,872169 -0,16413 0,592612 0,127774 -0,71903 -0,46505 -0,56951 0,644074 0,770465 NCI_Reelin_signaling_Pathway_(neuron_migratio 0,071471 -0,01266 -0,04667 -0,02703 -0,38355 -0,49669 -1,42522 -1,14206 -1,2431 0,019856 -0,30748 0,027564 0,123789 0,103357 0,362692 -0,09542 0,170662 0,328978 0,644752 0,77098 NCI_LPA4_mediated_signaling_events_Main_Path -0,29152 -0,02049 -0,06641 0,071972 0,32204 -0,34585 -0,99557 -0,83255 -0,77553 -0,58322 -1,13041 -0,26843 0,181562 0,862068 0,749897 2,54674 2,405011 2,368286 0,647548 0,773433 NCI_LPA4_mediated_signaling_events_Pathway_( -0,29152 -0,02049 -0,06641 0,071972 0,32204 -0,34585 -0,99557 -0,83255 -0,77553 -0,58322 -1,13041 -0,26843 0,181562 0,862068 0,749897 2,54674 2,405011 2,368286 0,647548 0,773433 reactome_Collagen_degradation_Main_Pathway -0,42963 -0,43309 0,165241 1,3589 0,203122 -0,08237 -0,2299 -0,52498 1,146786 1,635829 -1,1508 0,385073 0,530806 0,215097 0,930539 2,152457 2,677391 1,847025 0,647091 0,773433 NCI_Alpha_synuclein_signaling_Pathway_(Pathwa -0,1394 -0,09969 0,087681 0,100565 1,288571 0,24604 -2,21618 -2,42447 -2,08687 -0,49115 -0,1388 0,380054 -0,17229 0,145773 0,566616 1,384877 -0,09648 1,130243 0,64929 0,774622 NCI_Alpha_synuclein_signaling_Pathway_(Pathwa -0,1394 -0,09969 0,087681 0,100565 1,288571 0,24604 -2,21618 -2,42447 -2,08687 -0,49115 -0,1388 0,380054 -0,17229 0,145773 0,566616 1,384877 -0,09648 1,130243 0,64929 0,774622 NCI_Alpha_synuclein_signaling_Pathway_(protein -0,1394 -0,09969 0,087681 0,100565 1,288571 0,24604 -2,21618 -2,42447 -2,08687 -0,49115 -0,1388 0,380054 -0,17229 0,145773 0,566616 1,384877 -0,09648 1,130243 0,64929 0,774622 Akt_Signaling_Pathway_Blocks_Apoptosis 0,042467 -0,2004 0,307535 -1,03957 0,427406 -1,05887 0,151723 0,187766 0,203401 -0,23171 0,754639 -0,76517 0,581636 0,43284 0,278976 -0,50113 0,742826 0,849065 0,650165 0,775281 biocarta_how_progesterone_initiates_the_oocyte 0,185359 0,215507 0,103343 -0,50505 -0,15329 -0,94379 0,751147 1,009617 0,660383 -0,37713 -1,50695 -0,8694 0,678072 0,420938 0,070425 0,668497 1,51382 1,07293 0,65034 0,775281 NCI_Regulation_of_p38_alpha_and_p38_beta_Ma 0,490508 0,071219 0,27767 -1,68837 0,496169 -1,12172 -1,72385 -1,5651 -2,17653 0,089978 0,577388 -0,12536 0,119159 0,512155 0,392995 -0,54741 -1,02556 0,039872 0,653629 0,778309 NCI_Regulation_of_p38_alpha_and_p38_beta_Pa 0,490508 0,071219 0,27767 -1,68837 0,496169 -1,12172 -1,72385 -1,5651 -2,17653 0,089978 0,577388 -0,12536 0,119159 0,512155 0,392995 -0,54741 -1,02556 0,039872 0,653629 0,778309 reactome_Interleukin_6_signaling_Main_Pathway -0,01719 -0,14862 -0,13891 -0,09244 -0,2938 -0,48087 0,107618 0,212395 -0,01123 0,22528 0,135397 0,10915 -0,40559 -0,0637 0,013285 -1,05984 -0,34274 -0,11872 0,653495 0,778309 reactome_RNA_Polymerase_I_Promoter_Opening -0,16023 -0,09018 0,257994 0,143084 1,05729 2,116324 -4,6993 -5,20299 -4,00013 -2,43427 -1,17302 -0,56502 0,850852 1,530515 -0,26564 4,245818 2,190188 2,642373 0,654412 0,778943 PAK_Pathway_Paxillin_Disassembly -0,00595 -0,00091 -0,0675 -0,32016 -0,09011 -0,10058 -0,38866 -0,42866 -0,37471 -0,09233 0,201579 -0,14361 0,17678 0,103616 0,161831 0,115181 0,128023 0,133647 0,654895 0,77922 KEGG_GnRH_signaling_Main_Pathway -0,29051 -0,60498 -0,55173 -0,99549 -0,31802 -1,9822 -3,70691 -3,21992 -3,97602 -1,97988 -0,07063 0,209252 0,117852 1,181146 1,743826 0,875195 2,231674 2,904072 0,655506 0,77965 biocarta_inactivation_of_gsk3_by_akt_causes_acc 0,150445 -0,08444 0,021749 0,192948 0,640465 0,673415 -0,20874 -0,09905 -0,34908 0,929104 0,027778 -0,60835 -0,01173 -0,25085 -0,02587 0,197131 0,145632 0,217505 0,658711 0,78131 Glucocorticoid_Receptor_Signaling_Pathway_Cell_ 0,015086 -0,02246 0,000653 -0,18793 0,010497 -0,01472 0,148924 0,139977 0,110387 0,205251 0,460311 0,477355 0,145552 -0,01083 0,163797 -0,46513 -0,48264 -0,61816 0,658514 0,78131 NCI_Class_I_PI3K_signaling_events_Main_Pathwa -0,16977 -0,2842 -0,34276 -0,60022 0,955766 0,805914 -0,21727 -0,73844 -0,12168 0,89424 0,181102 0,182325 -1,16496 0,172593 0,535147 -0,90404 -0,85382 0,701162 0,657708 0,78131 NCI_E_cadherin_signaling_in_keratinocytes_Pathw -0,08746 0,00102 -0,03453 -1,10548 0,302682 -0,87929 -0,31122 -0,30242 -0,52452 0,431666 1,344513 0,858801 -0,33138 -0,16461 0,160898 -3,64749 -2,13259 -2,2252 0,657582 0,78131 NCI_Stabilization_and_expansion_of_the_E_cadh 0,042034 0,038893 0,081915 -0,26173 0,15063 -0,09565 -0,30554 -0,37779 -0,44533 0,919836 1,079115 1,324073 -0,53035 -0,09676 -0,09094 -1,456 -0,95935 -1,04645 0,65916 0,78131 NCI_Stabilization_and_expansion_of_the_E_cadh 0,042034 0,038893 0,081915 -0,26173 0,15063 -0,09565 -0,30554 -0,37779 -0,44533 0,919836 1,079115 1,324073 -0,53035 -0,09676 -0,09094 -1,456 -0,95935 -1,04645 0,65916 0,78131 NCI_Stabilization_and_expansion_of_the_E_cadh 0,042034 0,038893 0,081915 -0,26173 0,15063 -0,09565 -0,30554 -0,37779 -0,44533 0,919836 1,079115 1,324073 -0,53035 -0,09676 -0,09094 -1,456 -0,95935 -1,04645 0,65916 0,78131 RALA_Signaling -0,17663 -0,09612 -0,3622 -0,61489 -1,65138 -0,45326 -2,00643 -1,88484 -1,88028 -1,09322 -0,27721 0,07469 0,36014 -0,18902 0,034731 -1,19089 -0,93426 -1,06835 0,65898 0,78131 reactome_Ras_activation_uopn_Ca2_infux_throu -0,02905 -0,19704 -0,01545 1,772709 2,742755 1,883849 -1,85605 -1,78315 -1,4899 0,934039 1,181812 -0,13223 -0,00733 0,182231 0,043282 3,847313 4,046399 3,444712 0,657799 0,78131 reactome_Golgi_Associated_Vesicle_Biogenesis_M0,490626 -0,55548 -0,65726 -6,16462 -5,65341 -6,07449 -6,17903 -5,12281 -7,94645 -2,27531 -0,27778 -0,13359 0,808434 0,45965 1,962898 -11,5718 -8,22799 -7,64524 0,659704 0,781658 NCI_EGFR_dependent_Endothelin_signaling_even 0,10803 -0,10589 0,050345 0,15601 -0,24635 -1,25095 -0,75048 -0,6392 -0,7412 0,104541 0,378275 -0,03673 0,260091 -0,13539 0,293258 -1,36341 -1,09572 -0,68895 0,660098 0,781827 NCI_Signaling_mediated_by_p38_gamma_and_p3 0,113967 0,008823 0,160216 1,309145 0,067557 0,15895 1,360954 1,489119 1,500493 0,055126 0,298236 -0,59784 0,948876 0,413268 0,545319 1,306968 1,569818 1,016212 0,660805 0,782367 KEGG_Circadian_entrainment_Main_Pathway -0,63463 -0,02027 -0,46619 0,56178 2,064485 2,666342 -0,84748 -0,99003 -0,77201 -0,19494 -1,65156 -1,89703 -0,04406 0,627807 0,10747 6,339836 7,072296 5,720112 0,661084 0,7824 Akt_Signaling_Pathway_Neuroprotection -0,01089 -0,09007 0,327066 -1,06167 0,458897 -0,80731 0,26046 0,221235 0,420016 -0,1756 1,202918 -0,5944 0,577724 0,497764 0,173458 -0,34869 0,230342 0,613337 0,664259 0,784667 cAMP_Pathway_Cell_Growth -0,28274 -0,40278 -0,13324 0,276512 1,871633 -0,09296 -1,64566 -1,70334 -1,09533 -2,5057 -0,03058 0,102002 -0,68172 -0,54892 -0,31247 1,233788 -0,18208 0,894786 0,664254 0,784667 hypusine_biosynthesis -0,07766 -0,09681 -0,07429 0,136979 -0,21727 -0,3788 -0,12866 -0,06963 -0,01233 0,65034 0,619679 0,247385 -0,20977 -0,24136 0,060474 -0,85588 -0,40151 -0,53628 0,663938 0,784667 reactome_Heme_degradation_Main_Pathway 0,1209 -0,03414 -0,00465 0,533306 -0,23641 -0,46479 -0,42178 -0,3023 -0,21197 -0,38963 -0,08351 -0,86482 -0,13294 0,080876 -0,23997 0,039112 -0,15266 -0,0223 0,663783 0,784667 tetrahydrobiopterin_ide_novoi_biosynthesis -0,01607 0,147394 0,057656 -0,17147 0,086952 -0,27705 0,226381 0,369326 0,19737 -0,63331 -0,13861 0,164376 -0,35219 -0,31848 -0,32786 -0,80429 -0,78921 -0,64634 0,663924 0,784667 KEGG_Signaling_pathways_regulating_pluripoten -0,0055 -0,00333 -0,01942 -0,15758 -0,02478 -0,05418 -0,05148 -0,0556 -0,06812 0,177642 0,131609 0,131716 -0,07693 -0,01568 -0,01301 -0,54525 -0,30586 -0,44361 0,665268 0,784965 NCI_ErbB1_downstream_signaling_Pathway_(cyto 0,111326 -0,0297 -0,11013 -0,54516 -0,27783 -0,72715 0,047487 0,204876 -0,24314 -0,08118 -0,24947 0,182802 -0,09717 0,111649 -0,05542 -1,36123 -1,06298 -0,6764 0,665078 0,784965 reactome_Activation_of_RAS_in_B_cells_Main_Pa 0,076115 0,146972 0,10154 -0,82742 -0,06003 0,090373 -0,02013 0,055937 -0,45296 -0,16358 0,215684 -0,19371 -0,1359 0,223594 -0,03615 -0,34356 -0,19099 -0,10431 0,665112 0,784965 GDP-L-fucose_biosynthesis_I_from_GDP-D-manno 0,053111 0,009863 -0,05041 -0,09333 -0,06623 -0,03119 -0,19107 -0,10537 -0,20912 -0,14039 0,173225 0,456497 0,287346 0,1864 0,249065 0,0924 0,16263 0,426278 0,6665 0,785824 JNK_Pathway_Insulin_Signaling 0,513047 0,801891 0,473553 -0,36818 0,866123 0,24712 0,866352 0,905288 0,771186 -1,67109 0,32716 -0,76008 -0,015 0,215741 -0,25098 0,768216 0,561657 1,457457 0,666332 0,785824 cysteine_biosynthesishomocysteine_degradation_ -0,00524 0,099065 0,060662 -0,05257 0,106041 -0,11204 0,039667 -0,04712 0,096783 0,124149 0,092248 0,19006 0,127156 -0,11806 0,15367 0,00968 -0,20834 0,045876 0,6681 0,786275 hydrogen_sulfide_biosynthesis_trans-sulfuration -0,00524 0,099065 0,060662 -0,05257 0,106041 -0,11204 0,039667 -0,04712 0,096783 0,124149 0,092248 0,19006 0,127156 -0,11806 0,15367 0,00968 -0,20834 0,045876 0,6681 0,786275 reactome_S6K1_signalling_Main_Pathway 0,158078 -0,04144 0,008077 0,196989 -0,5491 -0,18307 0,525058 0,623131 0,229109 0,218667 0,90094 0,822012 -0,1003 -0,13639 0,043416 -1,55046 -1,66439 -1,32158 0,667143 0,786275 spermine_and_spermidine_degradation_I -0,17675 0,000529 -0,06505 -0,2967 -0,04651 -0,21895 -2,31755 -2,46347 -2,18519 0,48735 0,863341 0,436085 0,245014 0,229922 0,066855 -0,56284 -0,33461 0,012556 0,668107 0,786275 thymine_degradation -0,18604 -0,04558 0,025133 0,233882 0,059214 -0,40632 -0,35181 -0,42879 -0,19603 0,533587 0,223052 0,44001 -0,41732 -0,09978 -0,29765 -0,04572 -0,52279 -1,04449 0,668397 0,786275 uracil_degradation -0,18604 -0,04558 0,025133 0,233882 0,059214 -0,40632 -0,35181 -0,42879 -0,19603 0,533587 0,223052 0,44001 -0,41732 -0,09978 -0,29765 -0,04572 -0,52279 -1,04449 0,668397 0,786275 NCI_ErbB2_ErbB3_signaling_events_Main_Pathw 0,37911 -0,1735 -0,25077 -1,14032 -0,99895 -1,74333 -0,49685 0,146172 -1,61032 0,820119 1,836081 2,623452 -0,23413 0,13365 0,702081 -7,05716 -4,315 -3,21649 0,669191 0,786912 NCI_Arf1_Main_Pathway 0,048163 0,001444 -0,08774 -0,64197 -0,5221 -0,76317 -0,52878 -0,24929 -1,0183 0,025151 0,773649 -0,03942 -0,11604 -0,16871 0,313182 -1,87898 -1,79418 -1,27178 0,672276 0,790242 reactome_CREB_phosphorylation_through_the_a -0,08272 -0,13222 -0,02427 2,074062 2,835999 1,883905 -1,91919 -1,79291 -1,81087 0,548206 0,882649 -0,82618 0,232187 0,100113 0,182179 2,074652 2,958331 2,935554 0,672629 0,790359 imyoi-inositol_ide_novoi_biosynthesis -0,06423 -0,25692 -0,06812 0,273616 -0,1857 0,256085 -0,56582 -0,65155 -0,63045 0,56971 -0,20504 0,187067 -0,03783 -0,0239 0,167985 0,499064 -0,02345 0,5576 0,672939 0,790424 NCI_Angiopoietin_receptor_Tie2_mediated_signa 0,237245 -0,43379 -0,58636 -3,57903 -1,84635 -2,95914 -3,39847 -3,6221 -4,33646 3,361427 0,962978 0,65818 1,640264 0,577309 1,80373 -3,97185 -1,66115 -0,52022 0,673283 0,790488 NCI_FGF_signaling_Pathway_(negative_regulation -0,07922 0,103758 0,109137 0,426986 0,194936 0,972266 -0,30806 -0,39025 -0,21437 0,075438 0,548929 -0,00409 -0,10329 0,01302 -0,20968 0,277481 0,230623 -0,07149 0,673501 0,790488 KEGG_Phosphatidylinositol_signaling_system_Ma -0,14138 -0,8693 -0,64088 -1,28375 -2,47155 -0,33724 0,817202 1,604585 -1,07539 -1,06156 -0,50748 -1,8291 -1,548 -0,48706 0,994871 -3,20337 -1,66864 -0,07451 0,674115 0,790693 NCI_Osteopontin_mediated_events_Pathway_(bo -0,10126 -0,2443 -0,19139 -1,22752 -1,52152 -2,11627 -2,95916 -2,7175 -3,18526 0,304314 -0,67567 -1,64743 0,060393 0,27055 0,393286 -0,74799 -0,7957 -0,2417 0,674183 0,790693 KEGG_Dorso_ventral_axis_formation_Main_Pathw0,126884 -0,03154 -0,01515 -0,13235 -0,49905 -0,1882 -0,42101 -0,33914 -0,68757 0,054157 0,277446 -0,19339 -0,22802 -0,13777 0,011514 -1,37614 -0,78757 -0,55313 0,675495 0,791934 Akt_Signaling_Pathway_Protein_Synthesis 0,200316 0,011308 0,327031 -0,09975 0,664729 -0,85991 0,03206 0,131229 -0,03281 0,606013 0,513182 -0,49646 0,81765 0,702581 0,450794 -0,31336 0,88029 2,223067 0,677417 0,793508 NCI_CDC42_signaling_events_Pathway_(cell_proli 0,034485 -0,02639 -0,02537 -0,03724 -0,16202 -0,05084 0,066141 0,099048 0,013085 -0,11786 -0,13597 -0,00374 -0,08341 -0,01999 -0,05121 -0,17626 -0,17357 -0,10917 0,677895 0,793508 NCI_CDC42_signaling_events_Pathway_(cytokines 0,034485 -0,02639 -0,02537 -0,03724 -0,16202 -0,05084 0,066141 0,099048 0,013085 -0,11786 -0,13597 -0,00374 -0,08341 -0,01999 -0,05121 -0,17626 -0,17357 -0,10917 0,677895 0,793508 Outside-in_Signaling_through_Integrins -0,23377 -0,58142 -0,38712 -3,00515 -2,01073 -2,64539 -7,01447 -6,96242 -7,82835 -0,62844 1,384553 2,164952 0,353093 0,462549 1,153351 -6,46695 -4,41228 -3,9995 0,677345 0,793508 reactome_Recruitment_of_repair_and_signaling_ 0,039249 -0,14497 -0,14141 9,51E-06 0,583977 0,01355 0,533412 0,69132 0,149381 0,073971 0,381228 0,315473 -0,16659 -0,43531 -0,24923 -0,88916 -0,4058 -0,34993 0,678112 0,793508 reactome_TRAF6_mediated_NF_kB_activation_M 0,161516 -0,13083 -0,02129 0,11933 -0,04574 -0,18625 -1,27105 -1,18107 -1,3987 2,331921 -0,28709 0,334443 0,281847 -0,77871 -0,01489 -1,8825 -2,05129 -1,17697 0,679247 0,794538 biocarta_bone_remodeling_Main_Pathway -0,23778 -0,15848 -0,07622 0,687137 0,378092 0,828381 0,207685 -0,01314 0,26867 0,047168 -1,07096 -0,99578 -0,32878 -0,56353 -0,2154 1,988186 1,543415 1,884815 0,680008 0,795129 retinol_biosynthesis 0,232426 0,064468 0,021231 -0,62604 0,396306 0,827708 -0,30263 -0,48569 0,022451 0,150351 -0,0344 -1,37503 0,894417 0,185309 -0,15027 1,34993 2,07944 1,380432 0,680286 0,795156 biocarta_cystic_fibrosis_transmembrane_conduct -0,48651 -0,14304 -0,35482 -0,46968 0,808622 0,328583 -0,95723 -1,13269 -0,60258 1,10712 1,141748 -0,33542 -0,88817 -0,38995 0,143955 -0,80335 -1,86307 -0,46358 0,681933 0,796783 KEGG_Herpes_simplex_infection_Main_Pathway -0,12542 0,548605 0,095782 2,22517 -0,37237 0,207078 1,561692 1,55434 1,963256 -0,43663 1,08758 -0,57707 -1,11612 0,111723 -1,12093 -1,52799 2,14198 1,048687 0,683099 0,797845 Growth_Hormone_Signaling_Pathway_Protein_Sy 0,06594 0,011138 -0,07469 0,013084 0,18663 -0,04195 0,200907 0,377048 0,087968 0,553012 -0,15171 0,827705 0,848777 0,970598 0,777782 0,67932 0,4169 0,936612 0,685219 0,799722 reactome_Transport_and_synthesis_of_PAPS_Ma 0,040459 0,098981 0,065098 -0,07335 -0,8176 0,486342 -1,12685 -1,01743 -1,10337 0,366092 0,00788 0,009477 0,231874 0,18196 -0,1432 -0,50913 -0,88746 -0,22996 0,685123 0,799722 HGF_Pathway_Cell_Adhesion_and_Cell_Migration -0,10006 -0,20466 -0,01002 -0,793 -0,41004 -0,57728 -4,86856 -4,84189 -4,63182 0,629992 1,039549 1,559827 0,090003 0,403849 0,362563 -0,83942 -1,04136 -1,03878 0,686342 0,800133 NCI_Cellular_roles_of_Anthrax_toxin_Pathway_(m -0,289 -0,13968 -0,13078 -0,45108 -0,25234 -0,47108 -0,26925 -0,00868 -0,00438 0,968965 -0,13378 -0,15392 0,272741 0,547058 0,163476 -0,80552 -0,37877 -0,08935 0,686105 0,800133 NCI_Endothelins_Pathway_(arachidonic_acid_sec -0,1358 -0,13062 -0,20786 -0,45502 -1,35171 -1,3906 0,268364 0,410597 0,157931 -1,07097 -0,79104 0,583013 -0,3539 -0,58762 -0,43481 -1,19749 -1,62958 -1,14664 0,686232 0,800133 reactome_Nef_mediated_downregulation_of_MH -0,0799 -0,14445 -0,18239 -1,34684 0,091973 -0,82992 -1,99916 -1,79629 -2,22824 -0,28566 -0,19051 0,643412 0,293604 0,244326 0,682552 -0,94416 -0,77083 -0,67063 0,687335 0,800991 reactome_Synthesis_of_Ketone_Bodies_Main_Pa 0,05096 0,042718 0,077365 -0,05299 -0,29106 -0,26025 0,257767 0,12893 0,218093 -0,24144 -0,25273 0,583218 0,236515 -0,1919 0,239092 -0,21756 -0,72664 -0,3741 0,687864 0,801307 reactome_POU5F1_OCT4_SOX2_NANOG_repress -0,00679 0,101538 -0,02956 -0,35896 0,114664 0,185167 0,210539 0,238089 0,182951 0,2801 0,338425 0,515298 -0,06265 0,021585 0,098347 -0,32294 -0,20213 -0,22057 0,68816 0,801352 chondroitin_sulfate_biosynthesis_late_stages -0,01224 -0,28595 -0,13186 -0,84529 -0,39149 -1,54359 -1,78779 -2,1675 -1,82958 -0,21249 -1,37869 -0,69917 -0,33424 0,188642 0,853907 -1,03551 0,08089 -0,84449 0,68917 0,801359 NCI_a4b7_Integrin_signaling_Main_Pathway -0,06144 -0,17018 -0,08384 -0,36228 0,299694 0,18848 -0,48228 -0,41816 -0,30709 0,485371 0,515727 0,544876 0,304598 0,017928 0,076219 -0,33333 -0,3257 -0,39116 0,688631 0,801359 NCI_a6b1_and_a6b4_Integrin_signaling_Pathway_ 0,013057 -0,18003 -0,07385 -0,60834 -1,26071 -1,66322 -0,93017 -0,84696 -1,14381 -0,20025 -0,06873 -0,70863 0,049084 -0,48096 -0,10452 -2,9868 -1,95016 -1,5944 0,689966 0,801359 NCI_a6b1_and_a6b4_Integrin_signaling_Pathway_ 0,013057 -0,18003 -0,07385 -0,60834 -1,26071 -1,66322 -0,93017 -0,84696 -1,14381 -0,20025 -0,06873 -0,70863 0,049084 -0,48096 -0,10452 -2,9868 -1,95016 -1,5944 0,689966 0,801359 NCI_a6b1_and_a6b4_Integrin_signaling_Pathway_ 0,013057 -0,18003 -0,07385 -0,60834 -1,26071 -1,66322 -0,93017 -0,84696 -1,14381 -0,20025 -0,06873 -0,70863 0,049084 -0,48096 -0,10452 -2,9868 -1,95016 -1,5944 0,689966 0,801359 NCI_RAC1_signaling_Pathway_(Pathway_positive_ 0,047618 -0,03806 0,07004 -0,10764 0,019599 0,118782 -0,45687 -0,38193 -0,56786 -0,37149 -0,51407 0,020418 0,270375 0,280426 0,300016 0,785213 0,90572 1,185855 0,689412 0,801359 reactome_Fatty_Acids_bound_to_GPR40_FFAR1_ 0,017544 -0,11565 -0,12987 0,193006 1,40185 0,729881 -0,36871 -0,48108 -0,40742 -0,21193 -0,18001 0,111891 -0,14153 -0,08903 0,146223 0,704771 0,881515 1,175828 0,688983 0,801359 reactome_Tie2_Signaling_Main_Pathway 0,033045 -0,28771 -0,30136 -1,85045 -0,53557 -1,4173 -2,03518 -2,17445 -2,00468 -0,42219 0,496809 -0,45764 0,550404 0,353268 0,62059 -2,93122 -1,08228 -0,4608 0,690957 0,802211 NCI_IL2_mediated_signaling_events_Main_Pathw -0,10749 0,005537 -0,17166 -2,69457 -0,60757 -4,19743 -2,28364 -2,09796 -2,82257 1,184507 0,588006 0,466538 -0,29829 -0,34479 -0,12582 -4,29308 -3,5806 -2,96235 0,691304 0,802314 lysine_degradation_I_saccharopine_pathway 0,077887 0,051412 0,074482 -0,63167 -0,83945 -0,98434 0,789201 0,88538 0,492822 -0,35618 -0,11591 -0,74561 0,129506 -0,00816 0,216377 -1,58011 -1,03713 -0,59326 0,693732 0,80481 NCI_Class_IB_PI3K_non_lipid_kinase_events_Mai 0,014677 -0,00469 0,019553 0,637381 -0,48684 0,250892 -0,21616 -0,18199 -0,25494 0,05936 0,681069 -0,12346 -0,27341 0,18847 0,146891 -0,77219 0,019218 0,057446 0,69423 0,80481 NCI_Signaling_events_mediated_by_focal_adhesi 0,068584 0,030098 -0,12269 -1,29127 -0,57988 -2,01938 0,062725 0,277374 -0,2034 -0,78836 -0,94582 -0,26956 0,639655 0,202977 0,655259 -1,77442 -0,98025 -0,6144 0,694005 0,80481 NCI_Caspase_Cascade_in_Apoptosis_Pathway_(ap 0,022587 -0,0133 0,068509 -0,66387 -0,22565 -0,0878 -0,25638 -0,08753 -0,32742 0,386226 0,396397 -0,04277 0,057138 0,080234 -0,16096 -1,21152 -1,15136 -0,81164 0,695179 0,805311 reactome_RIP_mediated_NFkB_activation_via_ZB -0,19158 -0,22916 -0,21065 -0,66993 -0,30999 -0,62116 -1,65046 -1,66976 -1,62679 2,769223 0,203866 1,839371 -0,03475 -0,78 -0,23516 -1,87992 -2,33669 -1,82689 0,695099 0,805311 biocarta_hiv_1_nef_negative_effector_of_fas_and 0,258924 -0,08831 0,040379 -0,51408 -0,05132 -0,93111 -2,08311 -1,76887 -2,31756 0,41344 -1,3641 1,066243 -0,71968 -0,47335 -0,74312 -2,3439 -1,48269 -0,26659 0,696797 0,806396 KEGG_Oocyte_meiosis_Main_Pathway 0,311256 0,495531 0,237033 -2,10518 -1,29919 -2,20767 0,295319 0,771241 -0,15272 0,565769 -0,4363 -1,49579 -0,91626 -1,56936 -1,10742 -6,40937 -6,44894 -4,29947 0,696396 0,806396 mTOR_Pathway_Cap-dependent_Translation 0,154388 0,130473 0,185726 -0,32292 -0,46605 -1,35353 0,388723 0,473112 0,035043 0,968993 0,877726 0,312827 0,603728 -0,16731 0,383374 -1,69503 -0,85577 -0,62255 0,696892 0,806396 reactome_IRS_related_events_triggered_by_IGF1 -0,15275 0,003249 -0,03466 1,268637 1,166299 -0,0581 -1,10529 -1,22893 -1,09364 0,664233 -0,36783 -0,267 0,23822 0,118672 0,053137 1,029673 0,804911 1,35104 0,697554 0,806863 Non-Junctional_Cell_Adhesion_in_Endothelium -0,08039 -0,16593 -0,34536 -2,58503 -1,70634 -2,18916 -4,38423 -4,80971 -4,969 2,260448 1,860156 1,089632 0,171684 0,551038 1,182432 -5,59956 -4,85206 -5,4616 0,698152 0,807255 VEGF_Pathway_Nitric_Oxide_Production 0,145465 0,01551 0,061043 -0,41278 0,476526 0,373543 -0,01147 -0,13445 -0,10147 0,064295 0,398304 0,011234 -0,09245 0,02985 -0,16901 -0,01668 0,063679 0,090717 0,699009 0,807946 reactome_Cross_presentation_of_particulate_exo -0,16101 0,113613 -0,08247 -0,16683 -0,40341 0,049418 -0,36759 -0,56211 -0,31631 -0,6143 -0,41851 -1,34027 -0,09393 -0,62878 -0,83885 0,128957 0,134282 -0,1349 0,699869 0,80864 KEGG_Cocaine_addiction_Main_Pathway 0,132022 0,227135 -0,03379 -2,7617 -2,33729 -3,32333 1,670752 2,097529 0,741324 -0,04677 -1,03404 0,918106 0,484419 0,588241 0,949246 -1,88035 -2,47207 -2,21241 0,700638 0,809228 NCI_Atypical_NF_kappaB_Pathway_(positive_regu -0,23543 -0,11047 -0,13918 -0,95652 0,893951 -0,64479 -0,27188 -0,33302 -0,28146 -0,15419 -1,16547 0,821324 0,292548 -0,03131 0,281592 -0,023 -0,46185 0,058462 0,701 0,809346 reactome_Serine_biosynthesis_Main_Pathway 0,010274 -0,04244 -0,06202 -0,813 -0,5468 -0,30031 0,84924 0,891685 0,74047 -0,74934 0,228129 -0,18664 -0,32003 -0,54026 -0,38684 -1,76433 -1,44995 -1,26329 0,701638 0,809783 cAMP_Pathway_Cytokine_Production -0,1099 -0,52931 -0,20582 0,79481 2,082135 0,132852 -2,06662 -2,04897 -1,35076 -1,79024 0,226429 -0,15904 -0,45907 -0,73109 -0,41666 1,669574 0,109783 0,990968 0,702157 0,810081 Erythropoietin_Pathway_Cell_Cycle_Progression 0,138075 0,061735 -0,01643 -0,27287 -0,34848 -0,49049 -0,51414 -0,3004 -0,83546 -0,69006 0,717796 0,458388 0,259714 0,31966 0,443136 -0,33501 -0,02744 0,315999 0,702497 0,810174 alpha-tocopherol_degradation 0,110961 0,164921 0,0384 0,277669 0,227663 -0,29169 -0,13442 -0,41691 -0,09481 0,312564 -0,14807 -0,0717 0,200699 0,389011 0,280197 0,055499 0,305017 0,444978 0,704498 0,81188 NCI_CDC42_signaling_events_Pathway_(RNA_spli -0,2374 -0,19547 -0,31416 -0,17693 -0,26885 -0,67441 -1,06444 -0,90576 -1,07001 0,500862 0,710286 0,040304 0,417868 0,499782 0,514983 0,212811 0,402139 0,177637 0,704477 0,81188 3-phosphoinositide_degradation 0,198736 0,110766 0,074149 -0,47444 -0,95784 0,627882 -2,48906 -2,10548 -3,4492 -1,96224 -0,25567 -2,58364 -1,25137 -0,90174 -0,87113 -1,61759 -0,97068 -0,24958 0,706987 0,814168 KEGG_Glycerophospholipid_metabolism_Main_Pa -0,46438 -1,01798 -0,92608 -0,23436 -3,17777 -3,00719 -0,31801 -0,13874 -0,60573 -0,87869 -1,65713 -4,3228 -0,25867 0,282993 0,848297 -1,23811 2,983811 2,740612 0,707492 0,814168 NCI_CDC42_signaling_events_Pathway_(establish 0,056152 -0,03018 0,005752 0,088369 -0,26537 -0,28381 0,097131 0,129906 0,021382 0,020442 -0,0622 -0,0229 0,028689 0,183644 0,145928 -0,15904 -0,10091 -0,17366 0,707529 0,814168 NCI_Thromboxane_A2_receptor_signaling_Pathw -0,10058 -0,11598 -0,05146 -0,80773 -0,83928 -1,11077 -0,9876 -1,09027 -0,80048 -1,26471 -0,47453 -0,84185 -0,48041 -0,58752 -0,17583 -1,45199 -0,86832 -0,05307 0,70713 0,814168 NCI_N_cadherin_signaling_events_Pathway_(oste -0,03287 -0,06854 -0,0768 0,174393 0,266418 -0,00588 -0,46587 -0,53953 -0,68124 0,4537 1,334448 0,639594 -0,35019 -0,00124 -0,09221 -1,25412 -1,20813 -0,85144 0,708194 0,814632 NCI_Urokinase_type_plasminogen_activator_uPA -0,92359 -0,5049 -0,77205 -0,81233 -2,82738 -1,01787 -4,06274 -4,79209 -3,30264 0,810059 -1,67999 -0,50008 1,013704 -0,00157 0,799263 0,072318 1,419043 0,082046 0,710676 0,817185 NCI_TCR_signaling_in_naive_CD4_T_cells_Main_P -0,43416 -0,41865 -0,27041 -0,01538 0,172818 0,13059 -2,14807 -2,34968 -2,37456 2,775832 1,18316 -2,15538 0,051305 0,468226 0,907321 0,875825 0,982282 1,774481 0,710962 0,817212 biocarta_signal_transduction_through_il1r_Main_ 0,519407 -0,21925 -0,05953 1,161895 -0,19238 -0,28572 -2,22343 -1,80018 -2,81663 1,280675 0,717776 1,756536 0,229215 0,635166 0,491677 -0,68795 -0,53392 -1,01733 0,711325 0,817329 reactome_VEGFR2_mediated_vascular_permeabi 0,190452 -0,40476 0,113437 -1,91971 -0,08269 -0,67382 -1,58582 -1,51393 -2,40843 0,910443 1,32513 2,023652 0,279708 1,140723 0,431215 -2,13847 -1,07251 -0,14025 0,71202 0,817826 Angiotensin-PTK2B_Pathway -0,0944 -0,28044 -0,33845 0,22029 0,346727 -0,04349 0,247018 0,318777 -0,03884 -0,94246 -0,45864 -1,54756 0,147331 0,205694 0,447729 1,103814 1,337246 1,893228 0,712584 0,818172 mTOR_Pathway -5,37923 -3,60788 -3,08908 -6,8274 -8,19708 -11,5468 -18,1836 -20,6945 -14,9519 2,863065 -7,44712 -5,15774 6,358581 6,059313 6,3251 -1,88443 -1,66397 1,134112 0,71328 0,818669 reactome_Activation_of_Rac_Main_Pathway 0,117528 -0,15993 0,036188 -0,45942 0,363838 -0,81896 -3,21328 -2,7124 -3,38857 -0,23755 0,463017 -0,28105 0,14327 0,953931 0,597396 0,224652 0,371486 1,791936 0,715448 0,820854 biocarta_tnfr2_signaling_Main_Pathway 0,044862 0,100511 -0,03665 -0,44999 -0,25601 0,574634 -0,27599 -0,29755 -0,38958 0,774625 0,193976 0,460695 -0,12939 -0,03738 -0,08417 -0,75515 -0,81021 0,196415 0,716723 0,821088 biocarta_tnfr2_signaling_Pathway_(Pathway_prot 0,044862 0,100511 -0,03665 -0,44999 -0,25601 0,574634 -0,27599 -0,29755 -0,38958 0,774625 0,193976 0,460695 -0,12939 -0,03738 -0,08417 -0,75515 -0,81021 0,196415 0,716723 0,821088 biocarta_vegf_hypoxia_and_angiogenesis_Pathwa -0,15401 -0,17083 -0,29494 -0,84601 0,335248 -0,5969 -1,55584 -1,69861 -1,3345 0,156263 -0,02569 -1,05787 1,025865 0,699604 0,616683 0,849065 0,700911 0,625065 0,719424 0,821088 CD40_Pathway_Gene_Expression_Cell_Adhesion_ 0,03197 0,215123 0,038755 -0,47108 -1,50559 0,721141 0,790143 0,820357 0,646762 0,625141 -0,88613 -1,5588 0,182746 0,459468 0,538573 -0,02853 -0,21227 0,299072 0,719639 0,821088 CD40_Pathway_Gene_Expression_Cell_Survival_v 0,03197 0,215123 0,038755 -0,47108 -1,50559 0,721141 0,790143 0,820357 0,646762 0,625141 -0,88613 -1,5588 0,182746 0,459468 0,538573 -0,02853 -0,21227 0,299072 0,719639 0,821088 CD40_Pathway_Gene_Expression_Co-Stimulatory 0,03197 0,215123 0,038755 -0,47108 -1,50559 0,721141 0,790143 0,820357 0,646762 0,625141 -0,88613 -1,5588 0,182746 0,459468 0,538573 -0,02853 -0,21227 0,299072 0,719639 0,821088 CD40_Pathway_Gene_Expression_COX2_and_Pro 0,03197 0,215123 0,038755 -0,47108 -1,50559 0,721141 0,790143 0,820357 0,646762 0,625141 -0,88613 -1,5588 0,182746 0,459468 0,538573 -0,02853 -0,21227 0,299072 0,719639 0,821088 CD40_Pathway_Gene_Expression_Immunoglobul 0,03197 0,215123 0,038755 -0,47108 -1,50559 0,721141 0,790143 0,820357 0,646762 0,625141 -0,88613 -1,5588 0,182746 0,459468 0,538573 -0,02853 -0,21227 0,299072 0,719639 0,821088 CD40_Pathway_Gene_Expression_Pro-Inflamator 0,03197 0,215123 0,038755 -0,47108 -1,50559 0,721141 0,790143 0,820357 0,646762 0,625141 -0,88613 -1,5588 0,182746 0,459468 0,538573 -0,02853 -0,21227 0,299072 0,719639 0,821088 CD40_Pathway_Gene_Expression_Procoagulant_A 0,03197 0,215123 0,038755 -0,47108 -1,50559 0,721141 0,790143 0,820357 0,646762 0,625141 -0,88613 -1,5588 0,182746 0,459468 0,538573 -0,02853 -0,21227 0,299072 0,719639 0,821088 EGF_Pathway_Actin_Cytoskeletal_Rearrangement -0,10416 -0,09905 -0,02765 -0,80825 -0,65399 -0,36997 0,099263 0,076999 -0,0848 2,114335 0,145608 0,628383 -0,27631 0,067147 -0,37995 -1,63361 -2,30435 -0,87283 0,72017 0,821088 NCI_Calcineurin_regulated_NFAT_dependent_tra -0,31042 -0,50676 -0,5526 -0,00228 0,320334 -0,00674 0,0823 0,046973 -0,03323 0,129705 0,267382 0,608392 -0,19622 -0,11905 0,494088 0,06844 0,35889 0,100264 0,717133 0,821088 NCI_FoxO_family_signaling_Main_Pathway -0,09323 -0,02281 -0,04524 -0,62367 -0,29133 -2,22423 -0,20021 -0,33777 0,03526 0,148995 0,445831 0,645469 0,041685 -0,23477 0,220525 -2,72148 -2,35813 -2,63605 0,716747 0,821088 Ras_Pathway_Receptor_Endocytosis -0,2199 -0,19804 -0,31061 -1,03124 -0,14519 -0,64142 -0,5256 -0,61523 -0,67626 -0,26746 0,324698 0,022748 -0,14771 0,178688 -0,16356 -1,333 -0,87217 -0,88656 0,720325 0,821088 reactome_A_tetrasaccharide_linker_sequence_is_ -0,85514 -0,7157 -0,77187 -0,46563 -0,33331 0,125348 2,16867 2,097217 1,986028 -1,6074 -1,31012 -0,55104 1,152604 0,540055 1,048696 4,962438 3,613504 3,273486 0,720396 0,821088 reactome_Advanced_glycosylation_endproduct_r -0,06974 -0,05943 -0,05495 0,318279 -0,60086 -0,28211 0,097499 -0,17751 0,151317 1,523405 0,800348 0,359734 -0,15601 -0,20837 -0,07643 -1,2743 -0,90417 -0,77731 0,718975 0,821088 reactome_AMPK_inhibits_chREBP_transcriptiona -0,06028 -0,12002 -0,18852 -1,00629 -0,58701 -0,67239 -0,53218 -0,44092 -0,61761 -0,88871 -0,40013 -0,36349 0,142861 0,372195 0,148834 -0,44781 -0,32073 -0,43085 0,719845 0,821088 reactome_Insulin_receptor_recycling_Main_Pathw0,038957 -0,11996 0,068761 -0,82335 -2,33212 -0,30715 -2,09303 -1,80947 -2,69838 0,412393 0,651492 -0,51464 -1,04329 -1,18084 -0,78339 -5,36808 -3,78257 -3,80107 0,716967 0,821088 NCI_a6b1_and_a6b4_Integrin_signaling_Main_Pa -0,157 -0,51936 -0,30887 -2,52674 -2,71416 -2,54386 -5,11531 -5,09031 -5,25568 0,030414 0,653704 -1,46563 0,342358 -0,35605 -0,23213 -5,52628 -4,49512 -3,32726 0,72095 0,821309 reactome_Glucagon_signaling_in_metabolic_regu -0,37873 -0,03712 -0,36089 1,320538 1,055535 -0,04981 -0,89746 -0,90782 -0,63108 -2,35705 0,102227 0,067775 -0,07414 0,614413 0,741208 1,916502 2,160693 2,44825 0,721118 0,821309 biocarta_gamma_aminobutyric_acid_receptor_lif -0,26295 -0,08046 0,098219 0,218023 -1,69772 -0,3936 -2,8622 -2,77626 -2,91737 1,160271 1,015951 0,29421 1,724359 2,025195 2,325329 2,300205 1,936975 2,269111 0,72218 0,821637 KEGG_Prion_diseases_Main_Pathway -0,1772 -0,32005 -0,39471 0,262783 -2,47439 -2,05171 -0,03694 0,332876 -0,71367 -1,20881 0,487001 0,772493 -0,53327 -0,45616 0,059348 -3,70576 -3,17922 -2,3798 0,722197 0,821637 reactome_Glycolysis_Main_Pathway 0,179548 0,075107 -0,03177 -0,894 -1,05239 -0,92521 0,196567 0,128939 0,037195 0,675501 0,914522 0,37744 0,038029 0,072455 0,092109 -2,73575 -3,0925 -2,24689 0,721776 0,821637 biocarta_adp_ribosylation_factor_Main_Pathway 0,342366 0,141153 -0,08452 0,264235 -0,49699 -1,60123 0,752157 1,280063 -0,01466 -0,70547 0,552808 0,181432 -0,86155 -0,44433 -0,52669 -4,74455 -1,68375 -1,49452 0,723206 0,822185 phosphatidylserine_biosynthesis_I 0,022513 0,020636 -0,00942 -0,07348 -0,07067 -0,25004 0,252051 0,262768 0,181557 -0,27626 -0,14062 -0,1288 0,014842 -0,03186 0,000765 -0,12262 -0,05214 -0,09409 0,723049 0,822185 NCI_FAS_CD95_signaling_Pathway_(necroptosis) 0,02568 0,077007 0,016692 -0,43776 -0,07619 0,111091 -0,51545 -0,39027 -0,47366 -0,31943 -0,21295 0,929218 -0,04458 -0,09436 -0,22207 -1,22395 -0,62247 -0,50395 0,724084 0,822883 NCI_mTOR_signaling_Pathway_(translational_init 0,06304 0,129779 -0,04068 -0,80599 -0,16323 -1,17513 -0,84858 -0,87938 -1,33065 0,72279 -0,59451 -1,4459 0,71991 0,158057 0,388583 -0,88282 -0,59813 0,12977 0,724392 0,822932 STATs_Pathway_Regulation_by_GH -0,48867 -0,7729 -0,66868 -1,45308 -0,01751 -2,59032 -0,51043 -0,26102 -0,85204 -0,28828 -0,03963 1,822704 1,390517 1,081882 1,01701 0,660645 0,83686 0,438042 0,724876 0,823182 ErbB_Family_Pathway -0,68005 -1,18405 -0,70723 -3,99501 -3,10337 -6,49706 -3,3504 -1,83611 -4,59729 0,976119 1,491541 -0,36243 1,718835 2,102147 3,348799 -8,14404 -5,73351 -1,59344 0,726112 0,824285 biocarta_fmlp_induced_chemokine_gene_express 0,015834 0,023712 0,166557 -0,05253 0,149314 0,095703 -0,048 -0,23717 0,09301 -0,02687 -0,11804 -1,10921 -0,06833 0,097321 0,236028 0,839767 0,40603 1,207919 0,727328 0,824875 ceramide_ide_novoi_biosynthesis -0,00382 -0,24344 -0,02205 -0,08023 0,012686 -0,62308 -0,46629 -0,36571 -0,63616 -0,16776 0,350446 0,304571 -0,17937 -0,21772 -0,11108 -0,94654 -0,92268 -0,75473 0,727074 0,824875 Smooth_Muscle_Tone_Regulation_by_G-protein_ -0,15166 -0,44308 -0,4381 0,644871 0,122215 -2,65985 -2,81529 -2,77845 -2,6499 0,991771 0,185085 -1,25507 1,070744 1,497024 1,739816 2,050609 1,922729 3,428133 0,727426 0,824875 biocarta_rho_cell_motility_signaling_Pathway_(fo 0,000382 0,105301 0,0446 -0,59083 -1,0145 -1,02479 0,138335 0,321118 0,135755 0,180718 0,531248 0,145567 -0,13276 0,025431 0,322979 -1,25487 -1,19487 -1,13347 0,728028 0,825258 KEGG_Collecting_duct_acid_secretion_Main_Path -0,06617 -0,0848 0,203788 -0,89641 -2,06786 0,109084 -2,60848 -2,63484 -2,66785 0,037814 0,995173 -0,41138 -0,38974 -0,31319 0,238837 -3,2911 -2,01982 -2,19819 0,728446 0,825431 PPAR_Pathway -0,98858 -0,55793 -0,45327 -0,96771 1,266576 0,569361 -4,00892 -3,36841 -3,31707 2,843563 1,380626 3,503514 0,338351 0,704179 1,458655 -1,08297 -1,11379 -0,69088 0,729013 0,825772 NCI_E_cadherin_signaling_in_keratinocytes_Main -0,48524 -0,0652 -0,33472 -1,3599 -0,07798 -1,42214 -0,1437 -0,04162 -0,18379 0,383977 2,245058 -0,0216 -0,66391 -0,26747 -0,15465 -4,81444 -2,40677 -2,77297 0,72977 0,826329 NCI_Signaling_events_mediated_by_the_Hedgeho -0,25091 -0,19791 -0,42223 -1,58455 0,940367 0,868365 -0,37206 -0,31658 -0,35183 1,541237 -0,35098 -0,97552 0,206115 -0,37044 -0,2414 -0,10447 -0,55365 -0,39125 0,730241 0,826563 cAMP_Pathway_Oncogenesis -0,08089 0,095983 0,078622 0,33823 0,693452 0,325036 -0,88976 -0,77071 -0,84619 -1,3343 0,038143 0,33571 -1,20778 -0,70498 -0,42892 -0,76247 -0,58743 -0,36044 0,733309 0,828737 KEGG_Synthesis_and_degradation_of_ketone_bo 0,128581 -0,07716 0,010742 -0,48698 -0,85407 -0,82263 0,360288 0,370566 0,066549 -0,47683 0,729651 1,24045 0,376153 0,019835 0,274342 -2,19642 -1,54339 -1,42524 0,732984 0,828737 NCI_ErbB4_signaling_events_Pathway_(axon_guid -0,09731 -0,02734 -0,00517 -1,383 -1,11557 -1,54596 -0,43818 -0,38673 -0,5451 -0,52284 -0,05211 0,078272 0,297799 0,216449 0,276556 -1,37497 -0,87819 -0,72195 0,733758 0,828737 NCI_ErbB4_signaling_events_Pathway_(heart_dev -0,09731 -0,02734 -0,00517 -1,383 -1,11557 -1,54596 -0,43818 -0,38673 -0,5451 -0,52284 -0,05211 0,078272 0,297799 0,216449 0,276556 -1,37497 -0,87819 -0,72195 0,733758 0,828737 NCI_S1P2_Pathway_(chemotaxis) -0,06386 -0,00139 0,029866 0,131809 0,20976 -0,25902 -0,22063 -0,21359 0,044073 -1,06449 0,750567 0,573501 -0,078 -0,41938 -0,28841 0,114384 -0,06667 -0,66112 0,732475 0,828737 reactome_TWIK_related_potassium_channel_TRE -0,04755 -0,00847 -0,00408 0,348333 0,86946 0,591153 -0,56697 -0,68245 -0,46906 -0,15829 0,465686 0,108022 -0,52033 -0,48119 -0,47754 -0,31671 -0,11615 -0,28188 0,733389 0,828737 NCI_IL2_mediated_signaling_events_Pathway_(na 0,004304 0,177106 -0,0382 -1,42313 -0,35734 -1,9232 -0,87467 -1,02976 -1,06858 -0,03955 0,829533 1,504752 0,373641 -0,10445 0,498032 -2,6149 -1,60423 -0,82548 0,734426 0,829191 reactome_GRB2_SOS_provides_linkage_to_MAPK -0,29775 -0,24387 -0,13338 -0,74441 -0,27891 -0,21187 -0,43571 -0,53077 -0,5152 -0,62947 0,416613 -1,19847 -0,18477 -0,23555 -0,86767 -0,54791 -1,05697 -0,73501 0,73479 0,829301 reactome_Signalling_to_STAT3_Main_Pathway -0,06805 -0,07886 -0,03323 -0,1445 0,004993 0,042381 -0,09276 -0,27684 0,040435 0,454325 0,023098 0,759847 0,203824 0,013969 0,150173 -0,22724 -0,03667 -0,02622 0,735491 0,829791 NCI_Integrins_in_angiogenesis_Main_Pathway -0,63277 -0,98436 -0,50323 -4,80032 -3,45333 -4,69953 -6,04332 -5,97811 -5,75881 -0,091 -2,19983 -0,42643 1,284363 1,188226 1,437962 -2,24867 -1,51915 -0,80744 0,73581 0,829851 reactome_Regulation_of_HSF1_mediated_heat_s -0,19898 -0,39821 -0,23516 -1,1867 -0,27012 0,26279 0,446434 0,777973 0,380995 1,547476 1,65372 0,923506 0,0836 -0,0634 0,110525 -2,57179 -2,66107 -1,43986 0,738335 0,832397 proline_degradation -0,08116 -0,04555 -0,04238 -0,16216 -0,15151 -0,34132 -0,03807 0,012356 0,006883 -0,11334 -0,5937 0,37793 0,215745 0,398188 -0,02475 0,089913 0,562618 0,226872 0,739418 0,833316 cAMP_Pathway_Chemotaxis -0,24351 -0,44838 -0,15113 0,5377 1,912932 0,034995 -1,67501 -1,75035 -1,08533 -1,83718 0,47182 0,520456 -0,43006 -0,39197 -0,11689 1,553615 0,03817 0,944577 0,740681 0,833835 NCI_Glypican_3_network_Main_Pathway -0,07141 0,038 0,044213 -0,57729 0,409596 -0,46408 0,384093 0,431901 0,267654 0,23274 0,62272 -0,72629 0,362106 -0,22825 -0,16188 -0,19672 -0,21072 -0,08502 0,740212 0,833835 reactome_Amine_compound_SLC_transporters_M0,159356 0,115364 0,163629 -0,96706 0,115482 -1,461 -0,29963 -0,60278 0,033077 -2,02611 -1,16514 -0,38293 0,71029 0,082549 0,484332 -0,3051 -0,12889 0,665002 0,740583 0,833835 SPP1_Pathway_in_Osteoclasts -0,04729 -0,45837 -0,45202 -3,57659 -4,24408 -4,47736 -2,47457 -2,01752 -3,36777 -1,60018 -0,46565 -0,66607 0,122179 0,182146 0,969515 -7,69488 -5,59825 -3,74093 0,741276 0,834204 reactome_Platelet_sensitization_by_LDL_Main_Pa 0,021822 -0,08596 -0,14178 -0,50564 -1,16555 -1,47246 0,500484 0,414144 0,398519 -0,69051 2,169465 0,843394 -0,13892 0,078666 0,187539 -3,74521 -2,6599 -2,28877 0,742739 0,835548 reactome_Synthesis_of_PA_Main_Pathway -0,10457 -0,09382 -0,14632 -0,95305 -1,66605 -2,35514 0,556279 0,815911 0,562952 -1,33422 -0,88145 0,418116 0,181214 -0,37422 0,44798 -2,47904 -2,38497 -1,79445 0,743425 0,836018 KEGG_beta_Alanine_metabolism_Main_Pathway -0,47099 -0,07176 -0,32965 -0,5708 -1,38017 -1,3241 0,328671 -0,11003 0,910215 -0,03169 1,164004 1,207848 0,605765 1,016168 0,255168 -1,21424 -0,65793 -0,21037 0,74497 0,836849 reactome_Assembly_Of_The_HIV_Virion_Main_P 0,125846 0,014024 0,037694 -0,71888 -0,48315 -0,78461 0,746576 0,804156 0,603071 -0,08419 0,268247 0,473191 -0,1607 -0,14634 -0,05636 -2,33745 -1,77269 -1,34805 0,744522 0,836849 reactome_Type_II_Na_Pi_cotransporters_Main_P -0,18332 0,020821 0,105642 0,168133 -0,06145 -0,05924 0,023131 0,07609 0,335366 -0,76267 -0,60777 -0,14764 0,015863 0,121924 -0,00703 1,203534 0,408903 0,89176 0,744719 0,836849 biocarta_phosphorylation_of_mek1_by_cdk5_p35 -0,30321 -0,56152 -0,40513 -0,84582 -0,19776 -1,23032 -1,56477 -1,47698 -1,58586 0,074188 1,10373 0,9193 0,22417 -0,70109 -0,15131 -1,63514 -1,58634 -0,81274 0,747347 0,839217 reactome_Facilitative_Na_independent_glucose_t 0,00113 -0,03029 0,06143 -0,67799 0,389993 -0,23814 -1,72745 -1,80869 -1,44779 -1,62305 0,4236 -0,20708 -0,03505 -0,04605 0,476702 0,400887 0,136183 -0,14338 0,748563 0,840278 reactome_Processing_of_DNA_double_strand_br -0,07345 -0,07483 -0,05611 0,049657 0,000548 0,078454 0,82757 0,989168 0,983224 1,025115 0,268934 0,485579 0,003975 0,141409 0,171824 -0,41714 -0,54547 -0,45232 0,749184 0,840673 biocarta_egf_signaling_Main_Pathway -0,18204 -0,31458 -0,36657 -1,0842 -0,96661 -2,34126 -0,23392 -0,16867 -0,3736 0,836721 -0,13951 -0,32246 0,156761 -0,40624 0,292794 -3,30902 -2,55853 -1,92319 0,75056 0,841807 NCI_Signaling_events_mediated_by_Hepatocyte_ -0,08385 -0,27485 -0,25612 -1,56432 -1,3434 -1,06622 -1,69984 -1,58037 -1,88802 0,351277 0,616503 0,666057 0,359513 0,107604 0,143458 -3,13342 -2,38836 -2,28052 0,750735 0,841807 reactome_Synthesis_of_epoxy_EET_and_dihydrox -0,21726 -0,17981 0,031675 1,081493 0,940937 1,061 -0,74877 -0,90962 -0,41109 2,656515 1,183463 2,037351 -0,22069 0,324584 0,32872 1,220382 -0,66481 0,458095 0,752867 0,843894 lipoate_salvage -0,03597 0,035822 -0,04159 0,013115 -0,10266 0,107089 -0,26345 -0,14369 -0,35552 0,066726 0,066834 0,053456 0,000161 -0,0995 0,088214 0,14402 0,06088 -0,19886 0,753899 0,844747 KEGG_Fc_gamma_R_mediated_phagocytosis_Ma -0,65502 -1,01243 -0,57165 -0,94508 -3,65195 -3,37473 -1,03498 -0,70917 -1,38395 -0,4521 -1,05491 1,606354 -0,05852 1,211301 1,580599 -5,30287 -2,98631 -0,64079 0,755753 0,846519 reactome_Axonal_growth_inhibition_RHOA_activ -0,13377 -0,01396 -0,01968 -0,36066 0,165289 0,845482 -0,8931 -1,08696 -0,85195 -0,49368 -0,26318 -0,58432 0,529027 0,464901 0,453312 1,414431 1,201702 1,154157 0,756136 0,846644 3-phosphoinositide_biosynthesis -0,58881 -0,32081 -0,63262 -0,38093 -1,40755 -0,79118 1,861611 2,107157 1,790175 2,412401 0,088602 2,128979 -0,46423 0,01784 0,485799 -4,1654 -2,54676 -2,36346 0,757202 0,847228 reactome_FGFR3b_ligand_binding_and_activation -0,18442 -0,21347 -0,08061 -1,01215 -0,61602 -0,76747 -0,69546 -0,87525 -0,57112 0,216721 -0,66585 0,239576 0,429887 0,16305 0,238845 -0,25812 -0,3337 -0,29495 0,757146 0,847228 KEGG_Bladder_cancer_Main_Pathway 0,102017 -0,17058 -0,30144 -0,57697 -0,44323 -0,42235 -0,31585 0,051962 -0,83658 -0,48638 1,009541 -0,19305 -0,49037 -0,07205 -0,33841 -1,0968 -1,05889 -0,67613 0,757763 0,847552 biocarta_transcriptional_activation_of_dbpb_from -0,02238 -0,01373 -0,02358 -0,10555 -0,09114 -0,11729 0,085349 0,084555 0,117083 0,034545 0,010675 0,053479 0,01399 0,035347 0,035093 -0,23341 -0,18274 -0,09283 0,758661 0,847947 reactome_Clathrin_derived_vesicle_budding_Mai 0,044594 0,081366 -0,02315 0,08206 -0,3336 0,038905 -0,30822 -0,28113 -0,50802 0,0532 0,802116 0,852983 0,199229 -0,14726 0,259618 -0,58705 -0,39467 -0,15844 0,758403 0,847947 NCI_RAC1_signaling_Pathway_(regulation_of_cell 0,169681 -0,03584 0,00601 -0,28842 0,042316 -0,01137 0,217043 0,347654 -0,08455 0,056628 0,753788 0,194183 0,515569 0,904322 0,689117 0,527425 1,040284 0,709745 0,761236 0,85052 NCI_Lissencephaly_gene_LIS1_in_neuronal_migra 0,054349 -0,03779 0,024936 -0,18768 -0,3232 -0,32107 -0,13317 -0,11072 -0,29822 0,216316 0,215261 0,158112 0,121334 0,234139 0,189949 -0,64136 -0,48659 -0,34788 0,763478 0,852719 NCI_Arf6_trafficking_events_Pathway_(regulation 0,096939 0,140267 0,186099 -0,08985 0,187275 -0,09832 -0,42419 -0,50107 -0,631 0,53083 0,974862 1,106187 -0,41078 -0,08218 0,105848 -1,96459 -1,3464 -1,35331 0,764885 0,853984 NCI_a6b1_and_a6b4_Integrin_signaling_Pathway_ -0,02318 -0,01409 0,055382 -1,55E-06 0,291316 -0,1335 -0,10371 -0,09395 0,026613 -0,11265 -0,01171 -0,25477 0,081822 -0,01757 0,061079 0,277651 0,397635 0,367475 0,766791 0,855806 KEGG_Parkinson_s_disease_Main_Pathway -0,10837 -0,28767 -0,17386 -0,12416 -0,83569 -0,26395 -0,53196 -0,3984 -0,64954 -0,4514 -0,33592 -0,57839 -0,06088 -0,007 0,126559 -0,07169 0,02075 -0,18205 0,768002 0,85685 Interferon_Pathway_Translation 0,073801 0,049913 -0,04478 -0,36825 -0,09907 -1,17584 0,724554 0,7476 0,482762 0,633076 0,187195 -0,37527 0,527842 -0,05343 0,346257 -1,32304 -0,7239 -0,56014 0,768842 0,857174 reactome_Nuclear_Receptor_transcription_Main_ -0,85416 -0,5417 -0,52646 -3,32316 -1,58513 -1,30376 -0,96117 -1,51766 -1,22459 -1,32861 0,289046 -0,10603 0,228142 -0,72938 0,836348 -1,3901 -1,12455 -1,48158 0,768782 0,857174 biocarta_influence_of_ras_and_rho_proteins_on_ 0,146767 -0,10012 -0,00086 0,068202 0,560543 0,579336 -0,16898 -0,07424 -0,34393 0,860586 0,095828 -0,4915 0,003686 -0,21824 0,015904 0,165784 0,146635 0,212183 0,770097 0,858265 chondroitin_sulfate_biosynthesis -0,25336 -0,34889 -0,37399 -0,70295 -0,57619 -0,78609 -0,54091 -0,84979 -0,59767 -0,50864 -1,56549 -1,04923 0,049793 0,089107 0,741825 0,390498 1,118755 -0,12538 0,772572 0,860716 reactome_POU5F1_OCT4_SOX2_NANOG_activate -0,21524 -0,06947 -0,22593 0,026894 0,315555 0,704777 0,130478 -0,09026 0,291244 2,230652 0,113048 0,25444 -0,38706 -0,08232 0,176367 -1,02283 0,292435 -1,18491 0,772867 0,860737 KEGG_Prolactin_signaling_Main_Pathway -0,24216 -0,43153 -0,77299 -1,74814 -2,11199 -2,29881 -1,93312 -1,67709 -2,86512 0,953509 1,083021 1,674187 0,049393 -0,71678 -0,00213 -7,48999 -4,42349 -3,49493 0,775868 0,863462 NCI_Urokinase_type_plasminogen_activator_uPA -0,08202 -0,07057 -0,13595 0,004915 -0,44675 0,426548 -1,22081 -1,19789 -0,94012 -0,93699 -0,42789 -0,74467 -0,02891 -0,0217 0,083951 0,203077 0,859763 0,752569 0,775698 0,863462 NCI_CXCR3_mediated_signaling_events_Pathway_ -0,17174 -0,11076 -0,0128 0,71396 0,224097 -0,71387 0,667061 0,946462 0,301277 1,721789 2,198138 0,129436 -0,80395 -0,34961 0,425948 -1,10489 -0,34533 -1,79843 0,778851 0,865882 NCI_IL2_signaling_events_mediated_by_PI3K_Pat -0,08949 0,321329 0,069221 -1,5613 -0,10615 -1,26327 -0,21011 -0,57093 -0,19113 0,405502 0,37052 1,068995 0,693864 0,166625 0,537647 -1,84583 -0,79861 -0,55867 0,778877 0,865882 NCI_IL2_signaling_events_mediated_by_PI3K_Pat -0,08949 0,321329 0,069221 -1,5613 -0,10615 -1,26327 -0,21011 -0,57093 -0,19113 0,405502 0,37052 1,068995 0,693864 0,166625 0,537647 -1,84583 -0,79861 -0,55867 0,778877 0,865882 Akt_Signaling_Pathway_Cell_Cycle -0,00603 0,074159 0,009465 0,423964 0,3716 0,195509 -0,62221 -0,69195 -0,5973 0,129934 -0,13802 -0,13913 -0,40342 -0,32731 -0,2479 0,12929 0,301966 0,067444 0,782991 0,870145 biocarta_caspase_cascade_in_apoptosis_Main_Pa -0,22087 0,060045 -0,18449 0,778711 -0,36042 0,038041 0,694112 0,561408 0,859735 0,539162 0,864395 1,884317 -0,19828 -0,50129 0,020509 -1,54455 -1,16425 -1,65828 0,783917 0,870261 KEGG_B_cell_receptor_signaling_Main_Pathway -0,3352 -0,78253 -0,55029 -2,33804 1,047348 -0,72254 -0,55043 -0,30263 -1,59754 1,611441 -0,82628 2,344789 -0,53702 -2,07475 -0,53551 -3,25783 -2,37039 -1,62408 0,783622 0,870261 reactome_Golgi_Cisternae_Pericentriolar_Stack_R 0,078909 -0,00226 0,024611 -0,30703 -0,67866 -0,51093 -0,46358 -0,33932 -0,63376 0,018313 0,111623 -0,24725 0,016675 -0,07777 -0,03713 -1,30843 -0,89512 -0,69429 0,784213 0,870261 sorbitol_degradation_I -0,01899 0,02965 0,001747 -0,35646 -0,14639 -0,39701 -0,11051 -0,10036 -0,09864 -0,33183 -0,2805 -0,23263 -0,00011 0,018512 0,043468 -0,02429 -0,06751 -0,09944 0,783972 0,870261 7-3-amino-3-carboxypropyl-wyosine_biosynthesis 0,042495 0,107864 -0,00709 -0,12522 -0,12684 -0,63854 0,191124 0,4133 -0,0022 0,321854 0,014549 0,350646 0,311461 0,122988 0,301852 -0,85503 -0,47396 -0,22167 0,784881 0,870383 reactome_Transcriptional_regulation_of_pluripot -0,27072 -0,24605 -0,0327 -0,17938 0,031358 0,392706 0,297451 0,175309 0,627133 -0,64957 -0,30711 -0,9047 0,130264 -0,21887 0,542489 0,972154 1,115027 0,692339 0,784603 0,870383 NAD_salvage 0,028463 -0,01853 -0,06533 -0,70417 0,176965 -0,12432 -0,91071 -1,10183 -1,0768 0,260428 0,807511 0,648899 -0,1809 0,262839 -0,0849 -0,83798 -0,61005 -0,60832 0,785548 0,870813 NCI_PDGFR_beta_signaling_Pathway_(receptor_r -0,06542 -0,09299 -0,19791 -0,34354 -1,35549 -0,64468 0,207321 0,126868 -0,05952 0,359031 -0,03017 0,439849 -0,15835 0,146526 0,575635 -2,45765 -1,20662 -0,42899 0,786545 0,871607 reactome_SMAD2_3_MH2_Domain_Mutants_in_ -0,10485 -0,08544 -0,10529 -0,39089 -0,7069 -0,22676 -0,70132 -0,75524 -0,93298 -0,53421 -0,15364 0,020774 -0,01729 0,130433 -0,02436 -0,59651 -0,54476 -0,11709 0,789042 0,873752 reactome_SMAD2_3_Phosphorylation_Motif_Mu -0,10485 -0,08544 -0,10529 -0,39089 -0,7069 -0,22676 -0,70132 -0,75524 -0,93298 -0,53421 -0,15364 0,020774 -0,01729 0,130433 -0,02436 -0,59651 -0,54476 -0,11709 0,789042 0,873752 reactome_VEGFR2_mediated_cell_proliferation_M0,024685 -0,22237 0,020503 0,022414 0,787338 -0,26763 -1,13658 -1,16242 -1,33192 1,353448 1,339581 -0,78112 0,256763 0,389433 0,151708 -0,90711 0,546369 -0,11723 0,789586 0,874045 biocarta_chrebp_regulation_by_carbohydrates_a -0,57452 -0,14992 -0,11419 -3,02932 -0,54687 -1,71106 -1,91461 -2,40771 -1,34853 2,22607 1,288682 -1,92021 -0,05945 1,118593 0,59139 -1,46465 -1,96959 -0,85286 0,7908 0,875077 HA_syntesis_pathway 0,132692 -0,19166 -0,31891 -0,38443 -1,53376 -0,70792 1,489998 1,927283 0,774109 -2,25851 -0,66548 -1,41318 -0,07834 0,200785 0,489792 0,241128 0,928488 1,715043 0,792436 0,876576 L-cysteine_degradation_I 0,004702 0,048966 0,066817 -0,29364 -0,15734 -0,1948 -0,22136 -0,23934 -0,32152 -0,01422 -0,11315 -0,23852 -0,05636 -0,02371 0,0207 -0,22827 -0,41528 -0,35132 0,795296 0,879249 NCI_ErbB1_downstream_signaling_Pathway_(tigh 0,211777 0,153655 0,22279 0,180142 -0,14241 0,221893 1,357776 1,276495 1,319965 -0,15971 -0,79855 -0,3469 0,020852 -0,17828 -0,13529 0,277103 0,111889 -0,04737 0,795417 0,879249 NCI_Signaling_events_mediated_by_the_Hedgeho -0,21999 -0,22406 -0,23594 -1,29502 0,374926 0,555693 -0,48589 -0,42742 -0,45272 0,476107 0,19178 -1,61239 0,346441 -0,30877 -0,27344 0,958965 0,427876 0,211884 0,797233 0,880944 reactome_Caspase_mediated_cleavage_of_cytosk -0,05443 -0,0559 -0,10017 -0,42001 -0,75116 -0,51816 -0,05668 0,062726 -0,28558 0,072297 0,152463 -0,17574 0,615675 0,009563 0,314024 -0,4072 -0,58469 -0,52982 0,797772 0,881227 iSi-methyl-5-thioadenosine_degradation 0,017109 -0,01645 0,020692 0,320094 -0,06031 -0,03429 0,02282 0,003117 0,147942 -0,15807 0,041364 -0,11263 0,194239 0,046676 0,065481 0,258119 0,400126 0,151727 0,798341 0,881543 KEGG_Galactose_metabolism_Main_Pathway -0,18231 0,145248 0,216765 -2,13667 -1,44335 -1,12437 0,779127 0,537664 0,893576 -2,66091 0,572736 0,765145 -0,3792 -0,32878 0,367442 -1,52947 -2,45608 -1,14892 0,804461 0,887986 KEGG_FoxO_signaling_Main_Pathway 0,246845 0,364073 0,334285 0,227425 -0,91498 -0,20759 -0,69257 -0,76773 0,866596 -1,75655 -0,00594 -1,726 0,441371 0,324034 -0,09013 2,414675 1,409636 -0,49436 0,805032 0,888302 Ras_Pathway_Increased_T-cell_Adhesion -0,1523 -0,25277 0,026478 0,023839 0,10884 -0,12392 -4,4323 -4,40303 -4,14227 0,891884 0,859209 1,798244 0,416068 0,786249 0,70561 -0,12117 -0,37762 -0,46374 0,807516 0,890727 biocarta_srebp_control_of_lipid_synthesis_Main_ 0,031673 -0,0763 -0,24017 -0,54276 0,152732 -0,45059 -0,78822 -0,79503 -0,9165 -0,58055 -0,39682 0,313815 -0,30247 -0,27564 -0,28494 -0,30178 -0,81511 -0,16483 0,810642 0,892653 biocarta_srebp_control_of_lipid_synthesis_Pathw 0,031673 -0,0763 -0,24017 -0,54276 0,152732 -0,45059 -0,78822 -0,79503 -0,9165 -0,58055 -0,39682 0,313815 -0,30247 -0,27564 -0,28494 -0,30178 -0,81511 -0,16483 0,810642 0,892653 cAMP_Pathway_eNOS_Signaling_Cardiovascular_ 0,009669 0,009138 0,045503 -0,60416 0,724255 0,421156 -0,85829 -0,8237 -0,88568 -1,4606 0,423826 0,499652 -0,8577 -0,40925 -0,35761 -0,7815 -0,72483 -0,37206 0,810695 0,892653 NCI_E_cadherin_signaling_in_keratinocytes_Pathw -0,02375 0,018107 0,018742 -1,0049 0,351004 -0,38283 -0,19201 -0,20922 -0,44427 0,82864 1,492763 1,037149 -0,47822 -0,0777 0,086957 -3,06956 -1,93037 -1,85428 0,810472 0,892653 reactome_FCERI_mediated_Ca_2_mobilization_M 0,111725 0,13666 0,184116 1,822939 0,770118 -0,47483 -0,32943 -0,91419 -0,48534 1,072145 1,074416 0,618802 -0,4108 -0,2366 0,615748 -0,07278 -0,37413 -0,54799 0,809735 0,892653 IGF1R_Signaling_Pathway_Glycogen_Synthesis -0,01133 0,020682 -0,02477 0,840061 0,897618 0,589422 -0,20427 -0,26554 -0,48638 0,365904 0,690664 0,220338 -0,33139 -0,27358 -0,22183 -0,11017 0,29202 0,242284 0,812348 0,893861 reactome_Synthesis_of_PIPs_at_the_plasma_mem -0,3188 -0,49217 -0,34387 -1,83477 -3,05124 0,109138 0,157929 0,721988 -0,85297 -0,82643 -0,45091 -1,023 -1,23905 -0,14746 0,060689 -3,54896 -2,32713 -1,21192 0,812366 0,893861 reactome_WNT_ligand_biogenesis_and_traffickin -1,09105 -0,62087 -0,54071 0,207892 -0,22881 -0,67733 -0,42416 -0,81237 0,91082 -0,00814 0,630769 0,91497 0,627001 1,660696 0,056924 0,934198 1,615709 1,639655 0,815219 0,896683 ethanol_degradation_II 0,209386 0,094804 0,04715 -0,40686 -0,25299 -0,29165 0,21165 0,366636 0,124104 0,879206 0,204922 1,013135 0,448273 0,636634 0,610439 -0,18173 -0,38208 -0,22128 0,816248 0,897498 reactome_PRC2_methylates_histones_and_DNA_ 0,23479 -0,09415 -0,49984 -0,49897 -1,29473 -2,5658 6,495576 7,158977 5,729418 0,92551 0,44083 0,152155 -0,79209 -1,33049 0,168396 -5,94675 -3,17964 -3,33361 0,818724 0,899903 NCI_Signaling_events_mediated_by_Hepatocyte_ -0,34682 -0,35054 -0,55492 -0,92801 -1,01887 -0,36882 -1,19233 -1,16821 -1,33627 -0,69631 1,301925 1,311597 -0,02469 -0,05979 -0,04052 -1,95737 -0,84096 -0,70374 0,819707 0,900666 reactome_Common_Pathway_Main_Pathway -0,31735 0,071847 -0,10212 -0,34479 -0,32312 0,888275 0,369929 -0,22897 1,261479 -1,53734 0,368806 -1,69759 0,315076 -1,09169 -0,21338 2,229427 0,587457 0,231898 0,820707 0,901128 reactome_Vitamin_B1_thiamin_metabolism_Main 0,039026 -0,11404 -0,00217 -0,03994 0,166026 0,15254 -0,15889 0,121371 -0,38102 0,518956 0,148391 -0,62488 -0,39936 -0,28075 -0,31634 -0,28784 -0,23748 -0,87224 0,820701 0,901128 reactome_Trafficking_and_processing_of_endoso -0,04606 0,046855 0,190308 -1,34685 -0,36364 -0,69449 -0,58573 -0,4661 -0,56927 1,74193 0,930755 0,053657 -0,05264 -0,08835 0,031255 -1,23662 -2,76459 -1,64337 0,822143 0,902387 NCI_Presenilin_action_in_Notch_and_Wnt_signal 0,249042 0,342398 0,073669 0,578186 0,426466 0,143638 -0,10206 0,046046 -0,46312 2,460843 0,379509 0,911243 -0,18131 0,330865 0,644032 -0,28003 -1,35757 0,886216 0,823019 0,902395 NCI_Signaling_events_mediated_by_PTP1B_Pathw0,133986 -0,06016 -0,02416 -0,49381 -0,58795 0,084291 -0,08144 -0,18045 -0,21367 0,570661 0,0839 0,304865 0,256196 -0,08761 0,214303 -0,96887 -0,77973 -0,65277 0,822935 0,902395 NCI_Signaling_events_mediated_by_PTP1B_Pathw0,133986 -0,06016 -0,02416 -0,49381 -0,58795 0,084291 -0,08144 -0,18045 -0,21367 0,570661 0,0839 0,304865 0,256196 -0,08761 0,214303 -0,96887 -0,77973 -0,65277 0,822935 0,902395 Cellular_Apoptosis_Pathway_Gene_Expression_F -0,03495 0,072162 0,004074 -0,45581 -1,41836 0,309454 0,219578 0,291068 0,122737 0,990819 -0,86351 -1,18703 0,156655 0,394692 0,56218 -0,15537 -0,32863 0,069305 0,823967 0,903117 flavin_biosynthesis -0,09046 -0,09838 -0,06436 -0,08613 -0,24002 0,117405 -0,30733 -0,31407 -0,40337 0,172052 0,202713 0,477453 -0,10195 0,051309 -0,02537 -0,46361 -0,41624 -0,3852 0,825632 0,904392 IGF1R_Signaling_Pathway_Cell_Migration -0,13962 -0,24627 -0,03875 1,481553 1,077135 0,279714 -4,81002 -4,73085 -4,37755 3,766466 0,946871 3,738128 0,192122 0,377139 0,550661 -0,04141 -0,63693 -0,16653 0,825833 0,904392 reactome_p38MAPK_events_Main_Pathway 0,067379 -0,2425 -0,26651 -0,21254 0,165473 -0,47343 -1,03183 -0,88565 -0,92986 0,619034 0,737144 -0,11557 0,131226 -0,0698 -0,04233 -0,76042 -0,42503 -0,77538 0,826001 0,904392 reactome_Adenylate_cyclase_activating_Main_Pa -0,336 -0,16886 -0,13943 -0,34818 0,230477 -0,32336 -1,22582 -1,02838 -1,05639 -1,31218 -1,53928 -0,63786 0,386491 0,715323 0,66737 2,70494 2,361146 2,227872 0,826808 0,904957 KEGG_Lysine_degradation_Main_Pathway 0,253386 -0,09907 0,063502 -0,81344 -0,38382 -0,91123 2,460305 2,723945 1,945904 -0,16148 0,851652 1,691741 -0,48716 -0,03296 -0,70428 -3,13501 -2,9367 -2,72775 0,831227 0,906926 KEGG_Melanoma_Main_Pathway -0,92782 -1,04551 -0,69326 -3,73591 -1,79038 -2,85638 -5,1359 -5,33557 -4,74778 0,327242 -1,71596 0,884558 -0,54421 -0,49877 1,038645 -3,84512 -2,55143 -1,31695 0,830368 0,906926 NCI_ErbB4_signaling_events_Pathway_(apoptosis -0,11866 -0,03071 -0,06564 -2,29772 -1,51279 -1,80108 -1,15243 -0,93233 -1,4377 -0,40428 0,258196 0,532125 0,464601 0,408701 0,531435 -3,34275 -2,61178 -1,91688 0,831141 0,906926 NCI_ErbB4_signaling_events_Pathway_(chemotax -0,11866 -0,03071 -0,06564 -2,29772 -1,51279 -1,80108 -1,15243 -0,93233 -1,4377 -0,40428 0,258196 0,532125 0,464601 0,408701 0,531435 -3,34275 -2,61178 -1,91688 0,831141 0,906926 NCI_ErbB4_signaling_events_Pathway_(dendrite_ -0,11866 -0,03071 -0,06564 -2,29772 -1,51279 -1,80108 -1,15243 -0,93233 -1,4377 -0,40428 0,258196 0,532125 0,464601 0,408701 0,531435 -3,34275 -2,61178 -1,91688 0,831141 0,906926 NCI_Signaling_events_mediated_by_the_Hedgeho -0,08048 -0,14189 -0,15352 -0,19549 0,75279 0,270792 0,643338 0,593802 0,906111 0,454187 0,186474 -0,17328 0,284134 -0,20632 0,171569 0,654191 0,691757 0,556644 0,829956 0,906926 NCI_Signaling_events_mediated_by_the_Hedgeho -0,08048 -0,14189 -0,15352 -0,19549 0,75279 0,270792 0,643338 0,593802 0,906111 0,454187 0,186474 -0,17328 0,284134 -0,20632 0,171569 0,654191 0,691757 0,556644 0,829956 0,906926 NCI_Signaling_events_mediated_by_the_Hedgeho -0,08048 -0,14189 -0,15352 -0,19549 0,75279 0,270792 0,643338 0,593802 0,906111 0,454187 0,186474 -0,17328 0,284134 -0,20632 0,171569 0,654191 0,691757 0,556644 0,829956 0,906926 NCI_Signaling_events_mediated_by_the_Hedgeho -0,08048 -0,14189 -0,15352 -0,19549 0,75279 0,270792 0,643338 0,593802 0,906111 0,454187 0,186474 -0,17328 0,284134 -0,20632 0,171569 0,654191 0,691757 0,556644 0,829956 0,906926 JAK-STAT_Pathway_IFN-Inducible_Gene_Expressi 1,263748 0,691978 0,842343 -2,02615 -0,41847 -3,69964 1,265183 1,231506 1,443085 0,839362 3,24694 3,159787 2,501933 3,223972 4,949021 0,350036 0,26458 -1,00423 0,832168 0,907548 reactome_Signalling_to_p38_via_RIT_and_RIN_M 0,076719 0,020457 0,008704 -0,13798 0,204622 0,662801 0,001449 -0,23368 -0,24271 0,259358 -0,22587 0,520411 -0,75206 -0,54354 -0,34169 -0,84015 -0,34821 -0,34545 0,832844 0,907548 reactome_Zinc_influx_into_cells_by_the_SLC39_g 0,131492 0,300433 0,255615 0,013031 -0,32727 -0,70147 -0,83161 -0,72976 -0,8205 -0,84843 -0,98388 -0,54031 0,199871 -0,14986 0,417596 -0,14798 0,177067 0,374278 0,832963 0,907548 TRH_Pathway -0,72844 -1,10546 -1,11673 0,432353 1,154308 -0,11032 -5,92603 -5,68607 -5,6967 -3,56669 0,716353 2,446896 -1,26687 -0,79138 0,100873 -1,40483 0,509673 2,124752 0,832485 0,907548 NCI_Class_I_PI3K_signaling_events_mediated_by_ 0,108629 0,003293 -0,07478 -0,82111 1,047783 0,2444 -1,64215 -1,43346 -2,29695 1,315506 0,843734 1,348525 0,36559 0,804599 0,373196 -0,39001 -0,41244 -0,40803 0,834009 0,90837 NCI_Urokinase_type_plasminogen_activator_uPA -0,05898 0,015708 -0,12297 -0,09096 -0,64619 0,027092 -0,22214 -0,31212 0,154417 -0,99998 -0,19462 -0,48052 0,139544 0,16933 0,158066 0,477789 0,809448 0,627054 0,834425 0,908505 NCI_RAC1_signaling_Pathway_(actin_filament_po 0,063279 0,00323 0,079434 -0,29189 -0,1616 -0,14298 -0,45484 -0,33054 -0,548 -0,74363 -0,73093 -0,25798 0,237356 0,311051 0,396073 0,362321 0,532263 0,808035 0,835014 0,908829 biocarta_downregulated_of_mta_3_in_er_negativ -0,01287 -0,01672 -0,00415 0,144158 0,343619 -0,00224 -0,04184 -0,07682 0,075717 -0,09447 0,140158 0,136113 -0,05499 -0,03189 0,021188 0,20608 0,099765 0,042187 0,836366 0,90903 mineralocorticoid_biosynthesis -0,30813 -0,33934 -0,07046 0,345847 0,032754 0,522375 0,237727 -0,17295 0,309221 -1,05382 -0,49804 -0,54562 0,066077 -0,21254 0,136148 1,545793 1,123296 0,884823 0,836125 0,90903 NCI_FOXA1_transcription_factor_network_Main_ -0,01287 -0,01672 -0,00415 0,144158 0,343619 -0,00224 -0,04184 -0,07682 0,075717 -0,09447 0,140158 0,136113 -0,05499 -0,03189 0,021188 0,20608 0,099765 0,042187 0,836366 0,90903 reactome_Transport_of_glucose_and_other_suga 0,106645 0,109102 0,288001 -1,37176 -0,09122 -1,33401 0,332406 -0,05533 0,580357 -2,67049 -1,16973 -0,3464 1,149048 0,38912 0,501235 0,064829 0,338154 1,084986 0,836022 0,90903 NCI_p38_signaling_mediated_by_MAPKAP_kinase 0,024655 -0,17634 -0,1839 -0,29605 -0,17717 -0,14751 -0,23887 -0,14096 -0,27784 0,32183 0,456181 0,009466 -0,01222 -0,01342 0,104321 -0,60146 -0,39706 -0,5202 0,836828 0,909215 NCI_IL8_and_CXCR2_mediated_signaling_events_ -0,02964 -0,02284 -0,11888 -0,36359 -0,16641 -0,27816 -1,76235 -1,89262 -1,54059 -0,04419 0,371452 -0,89505 -0,31203 -0,55475 -0,16168 -1,79194 -0,29088 -0,35152 0,837809 0,909963 NCI_Signaling_events_mediated_by_HDAC_Class_ -0,07956 -0,07269 -0,18435 -0,43226 -0,60575 -1,04672 0,263993 0,154464 0,135992 -0,71537 -0,69025 -0,86877 -0,12454 -0,38712 -0,24509 -0,75673 -0,30201 -0,27325 0,838235 0,910108 NCI_Atypical_NF_kappaB_Pathway_(Pathway_deg -0,28735 -0,18178 -0,09944 -0,40678 1,274634 -0,75812 -0,71745 -0,81696 -0,6216 -0,18611 -1,66818 0,057686 0,241156 -0,13612 0,300758 1,18822 0,514605 0,700717 0,838684 0,910179 NCI_Thromboxane_A2_receptor_signaling_Pathw -0,12316 -0,15843 0,110933 -0,95988 -1,20676 -1,32609 -0,80234 -1,09551 -0,51583 -1,44741 -0,91292 -1,15671 -0,18532 -0,27739 0,140201 -1,24995 -0,31118 0,129971 0,839088 0,910179 pentose_phosphate_pathway_non-oxidative_bran 0,214191 -0,01777 0,033068 -0,34373 -0,81581 -0,96738 -0,13608 -0,1085 -0,34028 0,087073 0,060713 0,025063 -0,35466 -0,13332 -0,28856 -1,94349 -0,96575 -1,30221 0,839177 0,910179 cAMP_Pathway_Glycolisis -0,03227 -0,22095 0,218373 -0,71955 0,038358 -0,70171 -0,54385 -0,33621 -0,73112 0,176078 0,888172 0,734154 0,683032 -0,15012 0,610101 -1,3121 -0,55301 -0,90029 0,840405 0,911194 NCI_Signaling_events_mediated_by_Hepatocyte_ -0,00927 0,043068 -0,08874 -1,12177 -0,13768 -0,87652 -0,22343 -0,28548 -0,4956 0,373629 -0,18539 -1,10781 0,545802 0,15526 0,383749 -0,29304 0,04771 0,226648 0,84113 0,911663 mTOR_Pathway_Lipid_Synthesis -0,25921 -0,19724 -0,27022 -1,36806 -0,31328 -0,08066 -8,01777 -7,98177 -8,5004 0,18094 -1,33199 0,338362 1,118002 0,248003 0,291632 -0,31609 -0,39259 1,338145 0,842691 0,913038 biocarta_atm_signaling_Pathway_(apoptosis) -0,07535 -0,09075 -0,14862 0,393 0,164828 0,176677 0,016469 0,292849 -0,07842 0,555362 0,936377 0,336189 -0,0638 -0,29083 -0,31369 -0,84299 -0,56062 -0,40653 0,844379 0,914397 KEGG_Riboflavin_metabolism_Main_Pathway -0,09601 -0,09268 -0,09028 0,129557 -0,46125 -0,08123 -0,22956 -0,26145 -0,27655 0,091668 0,335379 0,393468 -0,14635 0,070683 -0,06415 -0,43514 -0,69188 -0,51356 0,844533 0,914397 reactome_Signaling_by_Leptin_Main_Pathway -0,21068 -0,29532 -0,14515 0,156739 -0,06404 -0,51706 -0,5152 -0,55641 -0,70291 1,513187 -0,3267 0,119315 -0,0282 -0,15947 0,227561 -0,86442 -0,43132 -0,37929 0,84486 0,914433 WNT_Pathway -3,68536 -3,28683 -3,09148 4,613817 6,618059 3,024167 -2,46078 -2,43005 0,434518 -4,5336 -0,69366 -3,70242 1,24081 1,851925 2,520866 14,84183 11,75973 16,64233 0,845946 0,915291 reactome_HDACs_deacetylate_histones_Main_Pa 0,321038 -0,15716 -0,40994 0,460577 -0,74765 -1,54811 4,367265 5,242562 3,749942 3,640896 2,300217 0,562169 -1,2378 -1,1368 -0,13063 -4,83045 -2,99579 -3,22619 0,846529 0,915603 glutathione_redox_reactions_II -0,05037 -0,04542 -0,05594 -0,32114 -0,23029 -0,28803 0,023644 0,043899 0,008563 -0,30464 -0,14186 0,210358 -0,02103 0,063805 0,00304 -0,4151 -0,10196 -0,12673 0,847413 0,916241 KEGG_Cytosolic_DNA_sensing_Main_Pathway 0,158783 -0,42405 -0,18999 -0,52017 0,469468 0,0983 -1,20154 -0,88366 -1,27598 0,283276 -1,37978 -0,40943 -0,09088 -0,50975 0,162964 0,981199 0,168468 0,725112 0,847724 0,916259 NCI_p38_signaling_mediated_by_MAPKAP_kinase -0,0116 -0,14408 -0,16649 -0,37725 0,010501 -0,02836 -0,20274 -0,15245 -0,16659 0,320681 0,468678 0,193411 0,115222 -0,02685 0,151774 -0,40664 -0,30879 -0,40747 0,848394 0,916665 reactome_APOBEC3G_mediated_resistance_to_H -0,1483 -0,16509 -0,09864 -0,64767 -0,4255 -0,75165 0,204753 0,306585 0,162155 0,046949 0,151836 -0,34689 -0,03958 -0,16611 0,019723 -0,75019 -0,83729 -0,56275 0,849935 0,917694 reactome_Integration_of_provirus_Main_Pathwa -0,1483 -0,16509 -0,09864 -0,64767 -0,4255 -0,75165 0,204753 0,306585 0,162155 0,046949 0,151836 -0,34689 -0,03958 -0,16611 0,019723 -0,75019 -0,83729 -0,56275 0,849935 0,917694 biocarta_bioactive_peptide_induced_signaling_M -0,15787 -0,35406 -0,44284 -0,08041 -1,02778 0,174959 -0,08818 0,062287 -0,51167 0,965296 1,206316 -1,40354 0,125953 0,246197 0,789047 -0,49233 -0,2169 0,613083 0,85251 0,918432 biocarta_regulation_of_eif_4e_and_p70s6_kinase -0,06669 -0,38165 -0,23521 -0,12045 -0,5726 -0,64682 0,022233 -0,04457 -0,31093 0,940377 0,526378 0,387621 1,64937 1,917852 1,930284 1,463134 0,880471 1,731186 0,8527 0,918432 mevalonate_pathway 0,014319 0,108854 0,013176 0,133268 0,333908 0,603594 0,906654 0,774459 0,936874 0,265034 1,345779 1,428372 -0,28195 -0,31611 -0,48173 -1,54158 -0,45509 -0,58651 0,852135 0,918432 NCI_E_cadherin_signaling_in_the_nascent_adher 0,025417 0,055876 0,086533 -0,14635 0,123969 -0,03431 -0,48798 -0,51758 -0,56601 1,099188 1,34299 1,30521 -0,60064 -0,22157 -0,14083 -1,87616 -1,38751 -1,45158 0,852501 0,918432 pregnenolone_biosynthesis -0,01932 -0,01661 -0,00562 -0,07817 -0,30578 -0,11611 -0,02379 0,018367 0,133079 -0,1206 -0,38661 -0,19584 0,029252 0,037679 0,110689 0,241887 -0,14017 0,015947 0,852058 0,918432 reactome_Bile_salt_and_organic_anion_SLC_tran -0,05271 -0,00626 0,124372 -0,4047 -0,2067 0,126992 0,632032 0,547453 0,54728 -0,64438 -0,00459 0,036535 0,438759 0,306571 0,016903 0,369924 0,467043 0,419984 0,852144 0,918432 reactome_GPVI_mediated_activation_cascade_M -0,71801 -0,29286 -0,58294 -0,3948 -0,18668 -0,89811 -0,35052 -0,84892 -0,45008 0,829182 0,636195 1,367317 -0,68816 -0,1201 -0,24471 -2,85905 -1,93494 -1,04662 0,852666 0,918432 reactome_Spry_regulation_of_FGF_signaling_Ma 0,08333 -0,02744 -0,0676 -0,16824 -0,17559 -0,43722 -0,30983 -0,33545 -0,40037 0,565636 0,487008 0,846083 0,094606 0,105596 0,305687 -1,51442 -0,81823 -0,42572 0,852978 0,918432 anandamide_degradation -0,08931 -0,11441 0,040674 0,034271 0,052184 -0,3886 0,220988 0,258454 0,397757 0,047317 -0,73651 -0,47914 -0,12444 -0,19182 0,112597 0,357048 0,0711 0,387536 0,85342 0,918591 reactome_Nicotinate_metabolism_Main_Pathway 0,012948 -0,06745 -0,01256 -0,85694 0,951447 0,684824 -0,60489 -0,91879 -0,75683 0,288486 -0,44736 -0,10522 0,188674 0,617978 -0,15362 0,713926 0,83246 0,41398 0,854657 0,919605 reactome_Fc_epsilon_receptor_FCERI_signaling_M0,127386 0,437516 0,307599 0,016717 0,186479 -0,01994 -0,04607 -0,32391 -0,05326 -0,39872 -0,6638 -0,72508 -0,49101 -0,5091 -0,29675 0,01306 -0,23776 -0,22932 0,855268 0,919945 biocarta_no2_dependent_il_12_pathway_in_nk_c 0,122843 -0,19151 0,116637 -0,82368 -0,04673 -0,12251 -0,13493 -0,23674 0,014226 -1,06249 -1,48715 -0,52651 0,09563 0,479636 0,977169 1,219229 1,459041 0,512581 0,856554 0,92101 NCI_E_cadherin_signaling_in_the_nascent_adher 0,021708 0,008808 0,059203 -0,08162 0,185619 0,142222 -0,7118 -0,77928 -0,91265 1,205602 1,188868 1,304007 -0,49803 -0,08496 -0,02109 -2,08547 -1,56428 -1,40673 0,857302 0,921496 NCI_Signaling_events_mediated_by_Hepatocyte_ -0,00029 -0,01992 -0,00412 -0,16914 0,416538 0,135763 -0,28281 -0,37431 -0,49492 0,49189 0,854449 0,569802 0,194117 -0,01366 0,097 -0,72059 -0,2356 -0,24228 0,857869 0,921787 biocarta_multi_step_regulation_of_transcription_ 0,062687 -0,07315 -0,22532 -1,4345 -0,52553 -0,75043 -1,37758 -1,44574 -1,93225 0,731264 1,316553 1,498922 0,795237 0,681673 0,941006 -1,62261 -2,35067 -0,72504 0,860125 0,92248 biocarta_regulation_of_splicing_through_sam68_ -0,05223 -0,26625 -0,26959 -0,09454 -0,16385 -1,08618 -0,46652 -0,22013 -0,58553 -0,89391 0,64283 0,653215 -0,34374 -0,46202 -0,20177 -1,81169 -1,31437 -0,72818 0,859409 0,92248 biocarta_stress_induction_of_hsp_regulation_Ma -0,23029 -0,41629 -0,20261 0,779981 0,719384 0,696582 -0,26831 -0,48718 0,213689 -0,5926 1,064571 0,978919 0,749336 0,449168 0,437363 1,797971 1,611521 1,217339 0,860116 0,92248 ErbB_Family_Pathway_Anti-Apoptosis -0,00127 0,070457 -0,00592 -0,0203 0,580891 0,196458 -0,45747 -0,62704 -0,67795 0,647546 0,409956 0,171168 -0,08927 -0,05138 -0,03111 -0,20193 0,123254 -0,11245 0,859742 0,92248 NCI_Signaling_events_mediated_by_the_Hedgeho -0,02007 -0,00705 -0,10142 0,065988 0,046029 0,620293 -0,00818 -0,01183 0,09322 0,699443 0,415416 0,028802 0,11893 0,055238 0,210236 0,367078 -0,03465 0,119833 0,85941 0,92248 reactome_Mitochondrial_iron_sulfur_cluster_biog 0,031717 -0,17911 -0,0358 -0,12227 -0,13393 -0,1517 -0,26947 -0,26602 -0,43243 0,396582 0,725469 0,67141 0,06372 -0,2018 -0,03972 -1,0624 -0,69074 -1,11853 0,86029 0,92248 KEGG_Staphylococcus_aureus_infection_Main_Pa 0,019861 0,305216 -0,0134 2,995639 2,365149 2,297129 -1,73183 -1,64947 -0,92015 0,615197 -1,30871 1,209053 -0,59965 0,258781 -0,991 3,051586 1,723864 2,543905 0,861873 0,922591 NADH_repair -0,00481 -0,04186 0,005591 -0,18301 -0,3075 -0,20593 -0,11128 -0,11287 -0,10905 0,429339 0,072798 0,300454 0,014461 -0,02584 -0,03146 -0,65309 -0,57169 -0,42697 0,861231 0,922591 NCI_Calcium_signaling_in_the_CD4_TCR_Main_Pa -0,25855 -0,40522 -0,5415 -0,04859 0,027952 -0,5066 -0,55072 -0,63941 -0,731 0,393019 0,930937 1,248895 -0,35299 0,036474 0,657103 -0,41686 -0,35838 -0,42851 0,86161 0,922591 NCI_Downstream_signaling_in_naive_CD8_T_cells 0,052177 0,204755 0,007616 0,071627 -0,12719 -0,22746 0,042058 -0,10231 -0,07634 0,509453 -0,33109 0,11021 -0,0707 -0,13663 -0,15968 -0,26712 -0,61804 -0,44227 0,862467 0,922591 reactome_regulation_of_FZD_by_ubiquitination_ 0,290473 -0,26384 0,076364 -0,76596 -0,4679 -1,29602 1,830994 1,841739 1,840529 -1,11391 -0,43486 -1,19485 -0,40616 0,277511 0,056549 -0,96729 -0,14462 0,336318 0,86178 0,922591 thyroid_hormone_metabolism_I_via_deiodination -0,02543 -0,03064 0,042007 -0,35295 -0,1471 -0,59455 0,017946 -0,01854 0,236143 0,836237 0,591147 -0,009 0,36237 0,022205 -0,06937 -0,65987 -0,82003 -0,72327 0,862394 0,922591 thyronamine_and_iodothyronamine_metabolism -0,02543 -0,03064 0,042007 -0,35295 -0,1471 -0,59455 0,017946 -0,01854 0,236143 0,836237 0,591147 -0,009 0,36237 0,022205 -0,06937 -0,65987 -0,82003 -0,72327 0,862394 0,922591 NCI_Signaling_events_mediated_by_Stem_cell_fa -0,04767 -0,01317 -0,01956 -0,67178 -0,7556 -0,76721 -1,2754 -1,2068 -1,44584 0,328748 0,393421 0,413747 -0,03144 0,003681 -0,03984 -1,58094 -2,03109 -1,39327 0,864944 0,924723 reactome_Metabolism_of_folate_and_pterines_M 0,214381 -0,02987 -0,10593 -0,26699 -0,28669 -0,74452 0,972677 1,162522 0,860921 0,070564 0,329813 -0,39386 -0,02192 -0,22608 0,029309 -0,70056 -1,05703 -0,3122 0,865054 0,924723 biocarta_cell_to_cell_adhesion_signaling_Main_P -0,20696 -0,16182 -0,28248 -0,35244 0,440899 -0,87919 -0,82389 -0,99788 -0,64293 0,059062 0,631505 -0,17774 0,610101 0,308594 0,657459 0,444983 0,669368 0,643832 0,867985 0,926099 biocarta_cell_to_cell_adhesion_signaling_Pathwa -0,20696 -0,16182 -0,28248 -0,35244 0,440899 -0,87919 -0,82389 -0,99788 -0,64293 0,059062 0,631505 -0,17774 0,610101 0,308594 0,657459 0,444983 0,669368 0,643832 0,867985 0,926099 biocarta_cell_to_cell_adhesion_signaling_Pathwa -0,20696 -0,16182 -0,28248 -0,35244 0,440899 -0,87919 -0,82389 -0,99788 -0,64293 0,059062 0,631505 -0,17774 0,610101 0,308594 0,657459 0,444983 0,669368 0,643832 0,867985 0,926099 NCI_Signaling_mediated_by_p38_gamma_and_p3 0,039816 -0,05833 -0,01475 0,214351 0,010142 -0,37124 0,608504 0,681935 0,568165 0,041331 0,018328 0,050307 0,369939 0,095569 0,156272 0,548713 0,064632 0,206142 0,868422 0,926099 reactome_Hydroxycarboxylic_acid_binding_recep 0,041029 0,030095 -0,1522 -0,07719 0,379037 -0,30649 0,13901 0,001408 0,021973 1,065468 0,279751 -0,74215 -0,07154 0,293325 0,007854 -0,27004 0,350662 0,031442 0,868218 0,926099 reactome_Interleukin_1_processing_Main_Pathw -0,02581 -0,23288 -0,17358 -1,19416 -0,69141 -0,93886 0,195519 0,274248 0,083037 -0,03416 -1,47121 0,167677 0,246358 0,139988 0,094165 -0,23415 -1,21797 -0,78864 0,866764 0,926099 reactome_SHC_mediated_cascade_Main_Pathwa -0,61597 -0,40971 -0,18761 -1,23741 0,192162 -0,4122 -0,63821 -1,10832 0,469511 -0,36974 -1,15424 -1,14264 -0,6924 -0,27611 -0,68572 -0,20265 -0,19986 -0,74423 0,868351 0,926099 reactome_Keratan_sulfate_biosynthesis_Main_Pa -0,56028 -0,1162 -0,30718 0,786861 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0,870998 0,927259 biocarta_il_2_receptor_beta_chain_in_t_cell_acti 0,189159 -0,00883 -0,23829 -0,73623 0,774331 -1,89813 0,026021 0,197636 -0,82319 2,112505 1,583624 2,476244 0,252449 -0,66036 -0,15104 -4,63711 -3,15543 -3,35131 0,871301 0,927264 KEGG_Toxoplasmosis_Main_Pathway 0,302015 -0,6492 -0,20426 -1,27827 -0,55477 -0,01821 -3,24768 -2,35471 -4,563 3,633309 2,839294 0,935551 0,560633 -1,06439 -0,13247 -2,58915 -4,04298 -2,62655 0,872358 0,928073 biotin-carboxyl_carrier_protein_assembly 0,045102 0,015617 -0,009 -0,2345 -0,39531 -0,18718 0,180918 0,188095 0,078614 -0,06158 0,251145 -0,09335 -0,00796 0,014339 0,03562 -0,42937 -0,34157 -0,38731 0,87271 0,92813 reactome_Interaction_With_The_Zona_Pellucida_ -0,60334 -0,26292 -0,30834 0,527798 -0,27864 0,796704 -0,35811 -0,38136 0,124563 1,411474 0,502288 0,411758 0,297248 0,589784 0,015374 1,461613 0,450783 0,279631 0,874214 0,929411 reactome_Binding_and_entry_of_HIV_virion_Mai -0,12356 0,028845 0,066827 -0,58568 -0,37672 -0,64745 -0,14766 -0,13729 -0,09928 0,740666 0,402325 0,165053 0,398429 0,395569 0,672217 -0,33224 -0,44363 -0,3307 0,875928 0,930916 reactome_Nef_Mediated_CD4_Down_regulation_ -0,14467 -0,10252 0,041247 -0,77706 -0,10884 -0,46811 -0,27376 -0,23072 -0,42189 -0,71682 0,793024 0,599746 0,32854 0,020775 0,585947 -0,58542 -0,21276 0,074885 0,876624 0,931338 NCI_LKB1_signaling_events_Pathway_(Pathway_d 0,043281 -0,01136 0,071647 0,086085 0,358827 0,025743 -0,04656 -0,0826 -0,06706 0,474034 0,362742 0,199078 -0,15757 -0,00637 0,017373 -0,13481 -0,18014 -0,18935 0,87701 0,93143 NCI_CDC42_signaling_events_Pathway_(actin_fila 0,013883 -0,04103 -0,01058 -0,21981 0,12043 0,117132 -0,31374 -0,24642 -0,38937 -0,00275 -0,07675 0,03016 0,420713 0,38358 0,355269 0,745649 0,398892 0,511006 0,878443 0,932635 reactome_Activation_of_the_mRNA_upon_bindin 0,228883 0,209107 0,233641 -0,29875 -0,34017 -0,53131 -0,06014 0,073475 -0,46586 1,089354 0,909003 0,286854 0,351088 -0,51544 0,025162 -2,26897 -1,25951 -0,84856 0,879562 0,933504 acetyl-CoA_biosynthesis_from_citrate 0,013074 -0,04256 0,007746 -0,08651 -0,25113 0,019459 0,160921 0,17087 0,137084 0,389886 0,468668 0,179644 0,106905 0,036593 0,05349 -0,34117 -0,31035 -0,38613 0,880462 0,934141 biocarta_angiotensin_ii_mediated_activation_of_j -0,11041 -0,48974 -0,40226 -0,66751 -0,87462 -1,4458 -1,30571 -0,73348 -1,8048 -1,62248 -0,10647 0,106639 0,148851 -0,21075 0,549867 -1,09618 -0,17605 0,642714 0,884514 0,935121 biocarta_mechanism_of_acetaminophen_activity_ -0,0146 -0,18976 -0,07307 -0,51416 -0,2642 -0,14129 -0,00925 0,001731 -0,14646 -0,29669 -0,18518 0,132017 0,207878 0,045529 -0,05837 -0,10471 -0,06751 -0,14021 0,886489 0,935121 biocarta_mechanism_of_acetaminophen_activity_ -0,0146 -0,18976 -0,07307 -0,51416 -0,2642 -0,14129 -0,00925 0,001731 -0,14646 -0,29669 -0,18518 0,132017 0,207878 0,045529 -0,05837 -0,10471 -0,06751 -0,14021 0,886489 0,935121 biocarta_mechanism_of_acetaminophen_activity_ -0,0146 -0,18976 -0,07307 -0,51416 -0,2642 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0,884904 0,935121 NCI_BCR_signaling_Pathway_(cytokine_secretion) 0,072848 0,088266 -0,0741 0,085078 0,106327 -0,65939 0,170706 0,161928 0,088354 -0,88368 0,370267 -0,68032 -0,28954 -0,38135 -0,10917 -0,64313 -0,63431 0,242576 0,881806 0,935121 NCI_Notch_signaling_Pathway_(Bergmann_glial_c 0,20945 0,296338 -0,00916 -1,80865 -0,17944 -0,31342 -1,83153 -1,47168 -2,57343 0,240791 0,978878 0,751672 -0,44752 0,148306 -0,6003 -3,95532 -1,34274 -1,19666 0,884603 0,935121 reactome_Adenosine_P1_receptors_Main_Pathw -0,02526 -0,03906 -0,00851 0,68115 -0,11903 0,111048 -0,24773 -0,35203 -0,1233 -0,48419 -0,47348 -0,36543 0,056267 -0,15806 -0,06786 1,049538 0,917407 0,492558 0,883945 0,935121 reactome_Basigin_interactions_Main_Pathway -0,3303 -0,18936 -0,35459 -0,20793 -0,1727 -0,36135 -2,57943 -2,61879 -2,20212 0,076556 -0,43265 0,514157 0,579024 0,425065 0,607215 0,608824 0,866602 0,882952 0,884709 0,935121 reactome_Depolymerisation_of_the_Nuclear_Lam -0,02256 -0,13168 -0,19155 -1,00016 -0,03124 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1,712989 0,884286 0,935121 NCI_BMP_receptor_signaling_Main_Pathway 0,067149 -0,13077 -0,06555 -0,56906 -0,28483 -1,75639 -1,06605 -0,64125 -1,98653 -1,96513 1,03413 -0,19686 1,184717 -0,7242 0,91814 -0,40895 -1,0301 0,155955 0,887061 0,935408 NCI_CD40_CD40L_signaling_Pathway_(proteasom -0,12515 -0,04759 -0,07843 -0,01959 -0,23049 0,493297 -0,17981 -0,18705 -0,17902 0,110927 -0,01624 -0,12868 -0,23895 -0,16821 -0,08459 -0,03937 0,043514 0,059827 0,88938 0,937536 biocarta_mcalpain_and_friends_in_cell_motility_P -0,01794 -0,05098 -0,16151 -0,48607 -0,60097 -0,81125 -1,11875 -1,00188 -1,31163 -0,09021 0,009005 -0,56333 0,096186 -0,15277 -0,33415 -1,28034 -0,90804 -0,11236 0,890087 0,937678 KEGG_Rap1_signaling_Main_Pathway -2,13021 -2,49566 -1,67701 -3,26638 -1,53996 -6,33005 -11,6097 -12,3885 -10,8392 -0,76256 -3,22115 -1,59282 1,434536 2,256732 5,325761 0,875702 4,723583 5,675412 0,89047 0,937678 reactome_SHC_related_events_triggered_by_IGF 0,071944 0,018494 0,009333 0,513829 0,719907 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0,938953 PAK_Pathway_Contractility_Stress_Fibres_and_Fo -0,51525 0,461046 0,252376 -2,02738 0,225927 -0,48131 -3,09579 -3,59882 -1,88432 -0,457 -2,58924 -2,31746 1,393258 3,00451 2,009758 3,515872 1,176291 5,274051 0,893466 0,9393 biocarta_il_2_receptor_beta_chain_in_t_cell_acti 0,022121 -0,11951 -0,18126 -0,39829 0,131766 -0,55464 -0,33501 -0,18034 -0,71888 0,236217 1,025295 0,974646 0,053906 -0,11906 0,15366 -1,4672 -0,87901 -0,35595 0,895206 0,939792 KEGG_Arginine_and_proline_metabolism_Main_P -0,45105 -0,16631 -0,2295 -3,39895 -2,28853 -3,68174 -0,55125 -0,96627 -1,16437 -1,38313 -2,42807 0,084094 0,633615 0,358425 0,341047 -4,97167 -2,49061 -1,21487 0,895269 0,939792 NCI_Signaling_events_mediated_by_Stem_cell_fa 0,007292 -0,05705 0,114145 -1,1892 -0,27154 -0,75305 -1,07193 -0,8797 -1,10589 0,66259 -0,13828 0,158836 -0,72462 -0,91379 -0,83575 -2,77418 -3,08118 -2,53943 0,896303 0,939792 NCI_Signaling_events_mediated_by_Stem_cell_fa 0,007292 -0,05705 0,114145 -1,1892 -0,27154 -0,75305 -1,07193 -0,8797 -1,10589 0,66259 -0,13828 0,158836 -0,72462 -0,91379 -0,83575 -2,77418 -3,08118 -2,53943 0,896303 0,939792 NCI_Signaling_events_regulated_by_Ret_tyrosine -0,23394 -0,052 -0,21711 -0,32644 -0,49178 -0,0978 -2,74209 -3,04494 -2,79004 1,24185 -0,15554 0,230591 -0,01946 -0,21654 -0,07124 -1,14776 -0,77894 -0,4393 0,896188 0,939792 reactome_Abnormal_metabolism_in_phenylketon -0,04408 -0,05107 -0,01362 -0,1674 0,003969 -0,1917 -0,1672 -0,26091 -0,13513 0,176482 0,056449 0,381203 0,054204 0,126682 0,085514 -0,19616 -0,1753 -0,16629 0,8949 0,939792 reactome_Synthesis_of_16_20_hydroxyeicosatetr -0,10286 0,399271 0,220413 0,923193 0,752488 -0,00764 -0,52241 -0,55226 0,074718 2,442587 -0,1866 1,33556 0,367391 0,895262 1,189268 0,902987 0,235401 0,541868 0,896347 0,939792 reactome_The_NLRP1_inflammasome_Main_Path -0,01698 -0,06358 -0,05214 0,090895 0,428118 0,257368 -0,38924 -0,26363 -0,29007 0,079721 0,368171 0,032992 0,005031 0,143573 0,001007 0,331005 0,511831 0,081741 0,895903 0,939792 acetate_conversion_to_acetyl-CoA 0,10078 0,063881 0,016315 0,01372 -0,04538 0,053406 -0,52361 -0,40125 -0,58642 0,963104 -0,21079 0,554045 0,257163 0,296311 0,363854 0,177196 -0,08577 -0,00349 0,896664 0,939808 thyroid_hormone_biosynthesis -0,01447 -0,08025 -0,12353 0,104846 -0,32674 0,081336 0,13139 0,073403 0,217879 0,046939 -0,34943 0,045595 0,126655 -0,00158 0,195536 0,455828 0,238763 0,178303 0,897802 0,940684 reactome_Phagosomal_maturation_early_endoso -0,251 -0,24411 -0,05148 -1,52609 -1,95506 -0,13803 -2,03306 -2,36768 -2,06257 -0,79872 0,665251 -2,4111 -1,03377 -1,37046 -1,46753 -3,33492 -2,53759 -2,9217 0,898527 0,941127 NCI_CXCR3_mediated_signaling_events_Pathway_ -0,17922 0,0171 0,105503 0,742462 0,588297 0,042392 1,37979 1,496892 1,177159 2,022476 1,718597 -0,50417 -0,67107 -0,06132 0,492861 -0,55549 0,214221 -1,63778 0,900322 0,94269 NCI_Angiopoietin_receptor_Tie2_mediated_signa 0,140378 -0,06042 -0,05341 0,061304 -0,30722 -0,2483 -0,87081 -0,797 -0,79779 0,722545 -0,16144 -0,40341 0,256901 0,190718 0,318801 0,266876 -0,13387 0,265279 0,901843 0,943302 noradrenaline_and_adrenaline_degradation -0,24602 -0,2623 -0,22963 -1,64291 -0,54795 -1,18177 -0,40175 -0,19922 0,253218 -0,21891 -1,25617 -2,12979 0,747641 0,441626 0,253503 0,971582 0,81683 0,233817 0,90196 0,943302 reactome_Beta_oxidation_of_butanoyl_CoA_to_a 0,001767 -0,05251 0,089026 -0,09336 0,102199 -0,3199 0,384287 0,479253 0,489002 0,953759 0,436443 0,66234 -0,04573 0,018351 -0,19475 -0,74803 -0,9297 -0,9412 0,902118 0,943302 reactome_MyD88_dependent_cascade_initiated_ 0,078646 0,021833 -0,03128 0,244961 -0,05122 -0,51069 -1,21877 -1,27079 -1,52377 0,59755 0,692745 0,662309 -0,00182 -0,0579 -0,05695 -0,79972 -0,83129 -0,77596 0,901696 0,943302 KEGG_Glucagon_signaling_Main_Pathway -0,05549 -0,62387 0,203192 -2,60044 -0,64789 -2,04279 -0,8442 -0,75877 -0,92233 -1,88921 -0,60866 -0,18055 1,433403 0,699081 1,885674 0,514761 0,798425 0,854637 0,903065 0,943664 reactome_Fibronectin_matrix_formation_Main_P -0,0898 -0,08563 -0,11997 -0,69242 -0,64986 -0,68096 -0,26462 -0,33736 -0,49341 0,198065 -0,1114 0,008566 -0,032 0,01701 -0,04242 -1,17062 -0,68549 -0,82759 0,90307 0,943664 KEGG_ErbB_signaling_Main_Pathway -1,24748 -1,01785 -0,94772 -3,43932 -3,45732 -4,86098 -3,20449 -2,33061 -4,19026 -0,30736 0,982907 -0,15669 0,97062 0,41365 2,885403 -5,52079 -1,91503 0,476514 0,904091 0,944414 reactome_Acyl_chain_remodelling_of_PE_Main_P -0,1199 0,173172 -0,07697 -0,80899 -1,2712 -1,54417 -0,39162 -0,21193 -0,0223 -0,61058 -1,53361 -0,81697 -0,10215 0,0484 -0,0244 -1,59119 -0,43174 -0,92848 0,905785 0,945867 KEGG_Prostate_cancer_Main_Pathway -0,52441 -0,85895 -0,98641 -3,45263 -0,73949 -3,86274 -2,03313 -0,97266 -3,61402 0,888388 -0,83831 3,440903 -0,58949 -0,70974 1,657643 -6,62762 -4,13212 -0,53745 0,906397 0,94611 NCI_VEGFR3_signaling_in_lymphatic_endothelium 0,051295 0,000466 -0,00961 -0,43517 -0,39938 -0,34965 -0,16569 -0,14703 -0,34268 0,588598 1,322103 1,285885 0,313336 0,5687 -0,24606 -1,29961 -1,13632 -1,21584 0,906626 0,94611 Nicotine_Influence_on_Glutamatergic_Neurons -0,09146 -0,21437 -0,33199 3,424196 4,419831 1,603664 -4,07078 -3,83188 -3,87409 -2,45499 0,268643 -0,18859 -0,44187 -1,2033 0,38918 3,571386 3,913351 6,434157 0,907716 0,946614 reactome_WNT5A_dependent_internalization_of_ -0,1726 -0,06369 0,047465 -0,54571 -0,04124 -1,29491 -0,71767 -0,78786 -0,98642 -2,35768 0,637859 0,870378 0,681706 0,544149 0,273646 -0,30735 0,155951 0,154048 0,907434 0,946614 Akt_Signaling_Pathway_Survival_Genes 0,191963 -0,13856 0,383282 -1,0942 0,87219 -1,0333 -0,21642 -0,16491 -0,24938 -0,02964 1,714503 -0,04558 0,671647 0,469239 0,422092 -1,10299 -0,17835 0,116817 0,910753 0,949146 reactome_Neurotransmitter_Clearance_In_The_S 0,165823 0,103317 0,162247 -0,14626 0,038957 -0,19173 -0,81776 -0,82826 -0,88284 -0,34608 0,472979 -0,45728 0,27608 0,132663 -0,18795 0,105314 0,028254 -0,49128 0,910512 0,949146 reactome_Downstream_TCR_signaling_Main_Pat -0,90208 0,019483 -0,38964 -0,72651 0,730474 1,907354 -1,06116 -1,48803 -0,54778 0,33391 -0,58235 1,827826 1,040878 0,229091 0,541475 1,300077 0,973889 2,473104 0,912445 0,950591 reactome_Activation_of_Matrix_Metalloproteinas -0,1144 0,113781 0,193415 0,642028 -1,14577 -0,13686 -0,45337 -0,42735 0,059036 0,836556 0,221891 1,1704 0,631053 0,13841 1,438985 0,302709 0,6027 -0,57766 0,914203 0,952103 NCI_Syndecan_2_mediated_signaling_events_Pat 0,015193 -0,07952 -0,01752 0,187942 0,237099 0,180139 0,033965 -0,0872 0,21701 0,126195 -0,20804 -0,61351 -0,29027 -0,18446 -0,26039 0,446748 0,174722 -0,17587 0,915905 0,9532 NCI_Syndecan_2_mediated_signaling_events_Pat 0,015193 -0,07952 -0,01752 0,187942 0,237099 0,180139 0,033965 -0,0872 0,21701 0,126195 -0,20804 -0,61351 -0,29027 -0,18446 -0,26039 0,446748 0,174722 -0,17587 0,915905 0,9532 reactome_Acyl_chain_remodelling_of_PG_Main_ -0,04067 0,053882 -0,00922 -0,76314 -1,38803 -0,33191 0,661044 0,553666 0,850431 -1,96561 -0,93655 -0,44876 -0,62833 -0,78338 -0,26012 -1,54752 -0,79407 -0,8194 0,916479 0,9532 TGF-Beta_Pathway_Post_Transciptional_G1_Arre 0,070795 -0,27213 -0,13396 -0,79212 -1,15443 -0,49444 -0,76337 -0,59584 -1,04581 -0,01812 0,774824 1,19253 0,068456 -0,19778 0,042478 -2,35066 -1,71769 -0,92563 0,916191 0,9532 NCI_VEGFR3_signaling_in_lymphatic_endothelium -0,03865 0,062417 0,211397 0,214098 0,311813 0,381927 -0,06124 -0,17705 0,065944 0,058639 0,076209 -0,10741 0,09731 0,10017 -0,07183 0,679967 0,519256 0,192119 0,91769 0,953778 NCI_VEGFR3_signaling_in_lymphatic_endothelium -0,03865 0,062417 0,211397 0,214098 0,311813 0,381927 -0,06124 -0,17705 0,065944 0,058639 0,076209 -0,10741 0,09731 0,10017 -0,07183 0,679967 0,519256 0,192119 0,91769 0,953778 sulfate_activation_for_sulfonation 0,051808 0,097095 0,079716 0,073412 -0,25477 0,035975 -0,2213 -0,15969 -0,1684 -0,23564 0,042648 0,057248 -0,07277 -0,05323 -0,13761 -0,17785 -0,43262 -0,17016 0,917954 0,953778 NCI_LKB1_signaling_events_Pathway_(establishm -0,14593 -0,16749 -0,21395 -0,68334 -0,34797 -0,90671 -0,36675 -0,28097 -0,55882 -0,40905 -0,0688 0,372676 0,004374 0,381298 0,134794 -0,49065 -0,71392 -0,50209 0,920352 0,95595 guanine_and_guanosine_salvage -0,07376 -0,09084 0,008833 -0,2102 0,030001 -0,13297 0,257356 0,244149 0,213475 -0,26342 0,228658 0,058831 -0,10657 0,096276 0,058726 -0,14738 -0,06153 -0,11785 0,922094 0,957122 KEGG_Fatty_acid_degradation_Main_Pathway 0,226049 0,105946 0,44101 -1,53529 -0,77948 -1,39588 0,610828 0,920987 -0,33323 2,440012 0,48657 2,552019 0,694439 0,762147 0,286789 -4,46427 -1,83836 -2,12464 0,92187 0,957122 guanosine_nucleotides_degradation 0,026803 -0,0736 0,008859 0,121584 0,252805 0,14201 0,314507 0,306445 0,084587 1,049262 0,403258 0,735635 -0,00563 0,120452 0,157518 -0,32905 -0,03334 -0,45408 0,922513 0,957238 Cellular_Apoptosis_Pathway_Gene_Expression_B -0,10472 -0,12522 -0,18298 0,830244 -0,14824 0,252012 0,213073 0,376234 0,222469 0,388461 0,057049 0,166144 -0,02694 -0,27025 -0,30841 0,11542 0,520821 -0,16739 0,923119 0,957547 NCI_Glypican_3_network_Pathway_(apoptosis) -0,00941 0,113971 0,159205 -0,21512 0,086724 -0,24464 0,381474 0,423163 0,177796 0,349763 0,372852 0,044618 0,442532 0,127329 -0,01998 -0,20041 -0,46451 0,017804 0,923965 0,958106 epoxysqualene_biosynthesis 0,068269 0,036463 0,039558 -0,07696 -0,02949 -0,02164 0,61675 0,590738 0,545264 0,02062 0,445409 0,171686 -0,12696 -0,16997 -0,16244 -0,72878 -0,48821 -0,33891 0,92548 0,959038 reactome_Meiotic_synapsis_Main_Pathway 0,279874 -0,27951 -0,51813 0,591157 -1,14542 -1,3274 6,577364 7,517456 4,837864 4,094719 3,557405 1,915765 -1,00373 -1,12554 0,269798 -7,97856 -3,61265 -4,2445 0,925184 0,959038 biocarta_regulation_of_pgc_1a_Main_Pathway 0,102301 -0,13466 -0,1467 0,398444 -0,21511 0,061202 -0,942 -0,67567 -1,48424 -1,64187 0,080413 -2,18364 -0,31964 -0,4479 -0,2706 0,392464 0,529443 1,476783 0,926143 0,959406 biocarta_d4gdi_signaling_Main_Pathway -0,13655 -0,24979 -0,38688 -0,42991 -0,86328 -0,91706 -0,1302 0,061652 -0,49421 0,369696 -0,77225 0,580337 -0,9124 -0,73833 -0,10225 -2,06987 -1,75783 -1,81351 0,928427 0,960495 biocarta_d4gdi_signaling_Pathway_(apoptosis) -0,13655 -0,24979 -0,38688 -0,42991 -0,86328 -0,91706 -0,1302 0,061652 -0,49421 0,369696 -0,77225 0,580337 -0,9124 -0,73833 -0,10225 -2,06987 -1,75783 -1,81351 0,928427 0,960495 NCI_Arf6_downstream_Pathway_(Tumor_Cell_Inv 0,034943 -0,07768 -0,07106 -0,29789 -0,51936 -0,17898 -0,21997 -0,19548 -0,27889 0,016795 -0,10502 -0,39227 0,262425 0,13447 0,060598 -0,07724 -0,09921 -0,14525 0,927741 0,960495 TNF_Signaling_Pathway_Apoptosis 0,231775 0,056277 -0,05598 0,084716 -0,88131 -1,87717 -0,11763 0,242162 -0,6983 1,192325 -0,75304 0,685261 -0,60827 -0,2497 -0,66569 -3,06066 -2,15278 -2,93154 0,92819 0,960495 NCI_Syndecan_4_mediated_signaling_events_Ma -0,27043 -0,47386 -0,24748 -0,53641 -0,6342 -0,80567 -2,66666 -2,50248 -2,74619 0,395424 -0,22529 -0,59606 -0,00803 -0,17292 0,615623 -1,14797 0,175525 0,296071 0,929221 0,960997 NCI_Glypican_2_network_Main_Pathway -0,03293 -0,03777 -0,14424 0,225289 -0,83601 -0,15649 -0,76954 -0,87372 -0,79776 -0,07596 0,05534 -0,16432 0,067743 0,104947 0,001252 -0,17558 -0,13317 -0,31351 0,930093 0,96158 NCI_Signaling_events_regulated_by_Ret_tyrosine -0,31406 -0,37507 -0,47709 -2,23662 -0,68157 -1,86213 -5,31837 -5,49153 -5,25917 0,750308 0,153815 0,124591 0,677448 0,175391 0,612873 -2,17464 -1,871 -0,30369 0,930937 0,962133 taurine_biosynthesis 0,057423 0,145837 0,14854 -0,41702 -0,25717 -0,43288 -0,32885 -0,32351 -0,34612 0,192402 0,249822 0,263245 -0,0761 -0,00319 0,383104 -0,41845 -1,05188 -0,63536 0,932434 0,963361 Mitochondrial_Apoptosis_Pathway 0,393986 0,507367 0,395177 1,996858 1,584402 2,461139 3,011804 2,667953 3,249295 1,607313 1,084147 3,142028 0,721147 -0,40159 -0,84948 1,271096 0,587418 -0,22459 0,932929 0,963377 NCI_Trk_receptor_signaling_mediated_by_PI3K_a -0,33694 -0,51292 -0,4302 -1,46159 0,710488 1,094262 -0,92991 -1,1612 -1,20144 0,398026 0,85667 0,3532 -0,42407 -0,92046 -0,49881 -1,3392 -0,39936 -1,19738 0,933841 0,963377 reactome_CYP2E1_reactions_Main_Pathway -0,09951 0,372131 0,024105 2,02903 1,92962 1,185407 -0,00468 -0,18106 1,285821 -1,0206 0,053463 0,566714 -0,68509 0,290732 -0,59841 3,279401 1,806286 0,747966 0,933267 0,963377 reactome_Elastic_fibre_formation_Main_Pathway -0,2465 0,227465 0,214852 0,367048 0,532269 0,13761 -3,25516 -3,38606 -2,66433 0,813304 -1,69112 -0,48877 0,64097 0,816672 0,656072 2,425219 1,421693 1,717374 0,933483 0,963377 reactome_WNT_mediated_activation_of_DVL_Ma -0,11478 -0,08196 -0,15567 -0,86909 -1,10162 -0,82132 0,682283 0,744589 0,705696 -0,41941 0,479125 -0,12872 0,12982 0,019443 0,277932 -1,16897 -0,93857 -0,78937 0,933996 0,963377 biocarta_how_progesterone_initiates_the_oocyte 0,279289 0,30102 0,078358 -0,84067 -0,63234 -1,08641 0,93388 0,872598 0,918995 -0,16541 -1,98754 -0,95267 0,289182 -0,06013 0,176998 -0,24344 -0,55522 0,268409 0,935856 0,964976 reactome_Sulfur_amino_acid_metabolism_Main_ 0,02752 0,065341 0,020078 -0,9341 -1,45428 -0,59226 -0,12352 0,037275 -0,69874 0,115218 0,708533 0,734147 0,117044 0,176169 0,166452 -1,78616 -1,54679 -1,79859 0,937238 0,96608 D-imyoi-inositol_134-trisphosphate_biosynthesis 0,099339 -0,07308 0,04185 -0,43462 -0,66297 0,40637 -1,03744 -0,92911 -1,60317 0,622741 0,148752 -0,17217 -0,54862 -0,27601 -0,95004 -1,0348 -1,32474 -1,77595 0,938489 0,966154 KEGG_Adipocytokine_signaling_Main_Pathway -0,12875 0,166185 -0,04485 3,655221 1,372456 2,558706 0,470606 0,044139 0,669924 1,687365 0,711252 0,333331 -0,0775 0,000544 -0,79593 3,246552 1,511596 2,015158 0,938676 0,966154 NCI_a6b1_and_a6b4_Integrin_signaling_Pathway_ -0,02632 -0,03701 -0,07459 -0,72754 -0,37559 -0,88855 -0,86264 -0,83137 -0,93286 -0,02229 0,56872 0,134478 0,055935 -0,11951 0,073231 -1,99239 -1,05551 -0,68415 0,938785 0,966154 NCI_CXCR3_mediated_signaling_events_Pathway_ -0,31542 0,110228 0,270496 0,846743 0,399907 0,160263 0,868141 0,885925 0,866192 1,490215 0,96273 -0,75388 -0,92347 -0,51279 0,073737 -0,34739 0,223871 -1,30285 0,938612 0,966154 NCI_Hedgehog_signaling_events_mediated_by_G -0,03447 0,022676 -0,10341 0,782754 0,781249 0,624185 0,962577 0,799681 0,776879 0,044654 0,316342 0,480154 -0,30229 -0,1203 -0,27446 0,467049 0,424861 0,452875 0,93917 0,966154 NCI_Hedgehog_signaling_events_mediated_by_G -0,03447 0,022676 -0,10341 0,782754 0,781249 0,624185 0,962577 0,799681 0,776879 0,044654 0,316342 0,480154 -0,30229 -0,1203 -0,27446 0,467049 0,424861 0,452875 0,93917 0,966154 reactome_Toxicity_of_botulinum_toxin_type_B_B -0,03362 -0,08119 -0,14179 0,183363 -0,09812 -0,49502 -1,30243 -1,15031 -1,32281 -0,96416 -2,05714 -0,71707 -0,0252 -0,2464 -0,25489 0,830422 0,88165 0,649148 0,940452 0,967154 reactome_Formation_of_apoptosome_Main_Path 0,14071 0,145676 0,138001 -0,26195 -0,32668 -0,19564 -0,04895 0,126226 -0,21723 0,220412 -0,25778 -0,69633 -0,16455 -0,20723 -0,25305 -0,70634 -0,70668 -0,48583 0,941575 0,967989 reactome_Effects_of_PIP2_hydrolysis_Main_Path -0,06645 -0,17042 -0,1597 -0,86714 -0,30289 0,582294 0,164377 0,333903 0,223137 0,592638 -0,2924 -2,07067 1,197065 0,551283 0,544032 1,614749 1,40195 2,050199 0,942283 0,968078 TGF-beta_Signaling_in_Epithelial-mesenchymal_tr -0,45694 -1,05971 -1,2043 -3,01858 -3,22574 -3,29071 -4,48744 -3,83158 -5,82186 1,91311 0,788396 3,935415 1,146433 0,44787 0,682856 -6,30737 -5,40294 -4,05109 0,942077 0,968078 reactome_Signaling_by_EGFR_Main_Pathway 0,107548 -0,033 0,12552 -0,48456 -0,15379 -0,36176 0,177488 0,300037 -0,11114 0,346115 0,026299 0,229943 0,393222 0,30876 0,461336 -0,54286 -0,14851 0,257756 0,944073 0,969596 Integrins_Function_in_Carcinoma_Progression -0,39781 -0,80622 -0,50149 -4,37189 -2,76775 -5,41028 -5,34919 -5,49098 -6,35731 1,84237 0,354576 -1,77821 1,718266 1,263301 1,555904 -5,81188 -3,61705 -2,2674 0,945511 0,97064 reactome_Triglyceride_Biosynthesis_Main_Pathw 0,093147 -0,04408 -0,12907 -0,50153 -1,19995 -1,22227 0,22851 0,393152 -0,1773 -0,33377 0,200323 -0,24131 -0,04636 -0,26868 0,552223 -1,60138 -1,21846 -0,97604 0,945712 0,97064 CD40_Pathway 0,802245 0,20526 0,287146 -1,77875 -2,46662 -0,39652 0,029776 0,695173 -0,46264 1,417741 0,323801 -0,32942 1,420496 0,559557 2,011603 -1,76083 -1,46838 0,047898 0,946354 0,970971 NCI_Arf6_signaling_events_Main_Pathway -0,0566 -0,73322 -0,34105 -4,10407 -1,50804 -2,32167 -3,28752 -3,42428 -3,1527 -2,78065 -1,978 -0,9315 0,512037 0,259246 0,158528 -0,39933 -1,52663 -2,26555 0,946658 0,970971 TRH_Influence_on_Cytoskeleton -0,25591 -0,36732 -0,28093 -0,28579 0,710923 -0,26424 -2,9044 -2,61332 -2,75673 -1,1941 -1,23616 -0,02527 -0,00748 0,536419 0,92972 1,02609 1,931589 2,542742 0,948942 0,972993 HGF_Pathway_IP3_Pathway -0,26633 -0,14076 -0,18136 -1,10171 -1,24111 -1,02816 -1,51653 -1,45033 -1,40029 0,634818 0,934823 0,77743 0,351574 0,157003 0,108121 -1,80503 -1,87331 -1,93355 0,950768 0,973213 KEGG_Nicotinate_and_nicotinamide_metabolism_ 0,486712 0,10054 -0,18618 -2,71305 1,109235 -3,47211 -0,31374 -0,58843 -0,21134 -0,61695 -0,07674 -0,23357 0,523592 0,464856 0,02274 -1,7739 -2,32605 -0,97911 0,950098 0,973213 NCI_p38_signaling_mediated_by_MAPKAP_kinase -0,05499 -0,26977 -0,28927 -0,16298 -0,11311 0,057267 -0,25705 -0,18609 -0,29248 0,651891 0,536816 0,486384 0,188551 -0,03174 0,300723 -0,37943 -0,05059 -0,18605 0,950243 0,973213 reactome_Sema3A_PAK_dependent_Axon_repuls -0,00981 -0,2486 -0,03998 -1,86289 -0,87467 -1,23631 -4,04151 -3,74734 -4,62239 -1,39628 -1,56592 -1,10819 0,50487 0,505879 0,113271 -0,49359 -0,64044 1,516814 0,951031 0,973213 reactome_Signal_regulatory_protein_SIRP_family -0,0862 0,005588 0,159617 0,193338 -0,0993 -0,59605 0,291927 0,292135 0,348303 -1,49302 0,064931 -0,26109 -0,42223 0,040395 0,049505 0,044691 0,007756 0,43218 0,950416 0,973213 reactome_STAT6_mediated_induction_of_chemo -0,04491 -0,00949 -0,0264 -0,08576 -0,25803 -0,19917 -0,33585 -0,39193 -0,37282 -0,17341 0,038661 -0,38026 0,14349 -0,04185 -0,02098 -0,15804 -0,31541 0,323882 0,950085 0,973213 Intermediate_Filaments_in_Epithelial_Cells -0,09996 0,041916 0,193386 -0,98645 -1,30917 -0,76502 0,430802 0,12728 0,159102 -0,82066 0,309829 0,383385 -0,03825 -0,62119 -0,00991 -2,61776 -1,85174 -0,91471 0,953673 0,975543 NAD_biosynthesis_from_2-amino-3-carboxymuco 0,0331 -0,04089 -0,02936 -0,77763 1,014613 0,577081 -0,70608 -0,99392 -0,7738 0,50351 0,034861 0,213264 0,06693 0,471063 -0,14626 0,440583 0,485965 0,024435 0,95456 0,975543 reactome_PKA_mediated_phosphorylation_of_ke -0,06757 0,005477 -0,04128 0,132167 -0,27285 -0,51668 -0,11355 -0,13088 0,029708 0,719379 -0,18446 0,711484 -0,10019 0,123918 0,237683 -0,2425 -1,0386 -0,34354 0,954348 0,975543 reactome_Regulation_of_IFNA_signaling_Main_P 0,694853 0,052651 0,908498 -0,33472 1,397184 -1,80116 0,117469 -0,20559 0,732445 0,225292 2,921908 3,252069 2,010868 2,527371 4,01524 1,596835 1,315919 0,256758 0,954466 0,975543 biocarta_pkc_catalyzed_phosphorylation_of_inhib -0,0856 -0,14988 -0,11364 0,730861 0,527152 0,438514 0,080599 -0,14703 -0,06787 0,909845 -0,17051 0,472327 -0,29924 -0,58962 -0,21247 0,211313 -0,07894 -0,23054 0,956252 0,976701 NCI_Cellular_roles_of_Anthrax_toxin_Main_Pathw -0,29683 -0,54659 -0,25611 -0,95008 -0,66393 -1,333 -0,45135 -0,1439 0,03804 3,086007 -0,79161 -0,37922 0,305874 0,756288 -0,20944 -1,44309 -1,18777 -1,61012 0,956321 0,976701 NCI_Noncanonical_Wnt_signaling_Main_Pathway 0,013673 0,050264 0,010032 -0,58808 -0,32949 -0,35433 0,139603 0,101694 0,023653 -0,12898 0,225499 -0,65714 0,23756 0,331873 0,247864 -0,4175 0,107423 0,204947 0,958759 0,97887 HIF1Alpha_Pathway -0,11755 -0,35063 -0,15362 -0,22069 1,496106 -0,39593 -0,6601 -0,47761 -0,50051 -0,34151 0,497694 2,927943 1,088743 0,606271 0,326774 0,868654 0,176552 1,058537 0,959449 0,979254 biocarta_bone_remodeling_Pathway_(Pathway_p 0,177694 -0,05239 0,109934 0,06423 -0,11313 0,305335 0,011182 -0,00398 0,115473 -0,04219 -0,50498 -0,75616 0,302917 -0,2157 0,353209 0,88443 0,739119 0,396713 0,960156 0,979654 NCI_CXCR4_mediated_signaling_events_Pathway_ -0,22653 -0,11828 -0,01108 -1,57829 1,097829 -0,67147 -1,95526 -1,98109 -2,08387 -0,09829 1,028489 1,018391 -0,1791 -0,085 0,843478 -3,5608 -0,67062 1,491917 0,960558 0,979744 NCI_Ephrin_B_reverse_signaling_Pathway_(endot 0,006377 -0,0395 -0,04087 0,155215 -0,06783 0,299004 -0,03162 0,075578 -0,05361 0,425186 0,38762 0,462184 -0,18986 -0,15048 0,032278 -0,73954 -0,19372 -0,08436 0,961143 0,98002 biocarta_regulation_of_splicing_through_sam68_ -0,04904 -0,2368 -0,23635 -0,026 -0,18226 -0,87486 -0,28076 -0,09791 -0,43434 -0,7238 0,593165 0,606338 -0,29571 -0,35858 -0,16043 -1,47422 -0,98677 -0,23225 0,963973 0,981432 biocarta_regulation_of_splicing_through_sam68_ -0,04904 -0,2368 -0,23635 -0,026 -0,18226 -0,87486 -0,28076 -0,09791 -0,43434 -0,7238 0,593165 0,606338 -0,29571 -0,35858 -0,16043 -1,47422 -0,98677 -0,23225 0,963973 0,981432 gluconeogenesis -0,22719 -0,19895 -0,10612 -0,1053 -0,66432 -1,45342 -0,19958 -0,26579 -0,18557 -0,78042 0,836459 -0,15306 -0,19978 0,016224 0,121857 -0,37887 -1,40395 -0,88294 0,964103 0,981432 proline_biosynthesis 0,004049 -0,05792 -0,01332 0,115628 0,290289 -0,13314 0,669614 0,717282 0,631073 -0,0366 -0,44954 0,497923 -0,30917 -0,56291 -0,24602 -0,52877 -0,2023 -0,55265 0,963061 0,981432 reactome_TAK1_activates_NFkB_by_phosphoryla 0,007948 -0,20993 -0,05395 -0,26973 -0,0682 -0,26773 -1,29755 -1,2986 -1,41761 2,151638 -0,56818 0,52673 0,005793 -0,96098 -0,06998 -1,64845 -1,82507 -1,00546 0,963824 0,981432 KEGG_Thyroid_hormone_signaling_Main_Pathwa -0,71135 -0,51509 -0,62492 -0,96967 -0,3231 -2,94894 -2,5273 -1,9317 -3,60147 1,149205 1,749552 2,895544 0,613248 1,008953 2,814308 -4,44348 -0,61945 0,979475 0,96457 0,981586 Erythropoietin_Pathway_Gene_Expression_Neuro -0,18002 0,260763 0,053454 -1,07634 -1,14899 -0,14992 0,245956 0,183307 0,423809 0,568332 -0,67295 -0,36742 0,251168 0,44865 0,30899 -0,66218 -0,52597 -0,65764 0,964971 0,981674 NCI_Notch_signaling_Pathway_(oligodendrocyte_ 0,17366 0,31308 0,011809 -1,94851 -0,15447 -0,31891 -1,61854 -1,13976 -2,21461 0,107165 0,945037 0,029294 -0,50205 -0,01678 -0,64365 -4,28435 -1,67071 -1,24079 0,965519 0,98191 biocarta_brca1_dependent_ub_ligase_activity_M 0,248444 0,053838 0,013721 0,190353 0,857593 -0,16923 0,874399 0,990748 0,468736 0,18548 0,567665 -0,2892 -0,35813 -0,39307 -0,1579 -0,14868 -0,4293 -0,16376 0,966892 0,982754 reactome_Activation_of_PPARGC1A_PGC_1alpha_ -0,01287 -0,27783 -0,26 -1,992 -1,21055 -2,70734 -0,6523 -0,38306 -0,94651 -1,16448 0,180341 -0,65543 0,179664 0,011559 0,153736 -2,66871 -2,08085 -1,63896 0,96698 0,982754 biocarta_the_41bb_dependent_immune_respons 0,294628 0,478805 0,062884 -0,99451 -0,47765 -1,14266 -0,24819 -0,40751 -0,39953 0,10642 -1,21016 0,72605 0,616688 0,582082 0,616251 -0,40428 -0,30624 -0,79843 0,967867 0,983335 biocarta_stat3_signaling_Main_Pathway -0,02164 -0,12843 -0,075 -0,65575 0,022413 -0,73272 0,143238 0,346872 0,048336 0,182703 0,214823 -0,03307 -0,12588 -0,04573 0,417652 -1,21977 -0,33738 -0,18596 0,970991 0,985721 carnosine_biosynthesis -0,06959 -0,07798 -0,0078 -0,21848 -0,14161 0,004705 -0,00295 -0,03203 0,179698 -0,12247 -0,04811 -0,03813 0,135531 0,202191 0,11411 0,084653 0,21825 0,179423 0,971165 0,985721 homocarnosine_biosynthesis -0,06959 -0,07798 -0,0078 -0,21848 -0,14161 0,004705 -0,00295 -0,03203 0,179698 -0,12247 -0,04811 -0,03813 0,135531 0,202191 0,11411 0,084653 0,21825 0,179423 0,971165 0,985721 asparagine_degradation -0,18705 -0,05536 -0,10965 -0,30044 0,341046 -0,01971 0,377991 0,296454 0,444634 -0,11228 -0,57855 0,240975 -0,13379 -0,20152 0,189214 0,416694 -0,10977 0,26178 0,971922 0,985847 NCI_EPO_signaling_Pathway_(elevation_of_cytoso 0,024847 0,104402 0,101726 -0,14687 -0,17484 -0,05786 -0,16285 -0,20018 -0,31035 -0,2674 -0,09175 -0,44393 -0,49241 -0,52361 -0,38488 -0,97277 -0,4432 -0,63523 0,97185 0,985847 KEGG_Cell_adhesion_molecules_CAMs__Main_Pa -0,30679 -0,42391 -0,23721 1,832612 1,985776 0,488277 -1,85975 -2,08875 -1,12313 1,59418 0,211073 1,693361 0,971246 0,546628 0,842421 2,969947 2,396445 2,259599 0,973578 0,986563 KEGG_Hedgehog_signaling_Main_Pathway -0,02997 0,118618 0,137592 0,970126 2,014951 2,207379 2,188738 1,756074 2,481558 -0,56712 -1,96703 -1,10659 -0,28225 0,175846 -0,31345 4,210386 3,519727 2,579736 0,973061 0,986563 reactome_FGFR2b_ligand_binding_and_activation -0,14596 -0,09329 -0,16619 -0,3829 0,539372 0,119941 -0,26284 -0,29289 -0,03213 0,682828 -1,25252 0,139363 -0,14145 -0,45776 -0,02789 0,300799 -0,16894 0,10766 0,973397 0,986563 KEGG_Axon_guidance_Main_Pathway 0,420335 0,66287 0,929053 -1,13135 -4,53376 -3,33172 0,840634 0,960475 0,284091 0,155846 0,025829 -0,59321 -0,66359 -1,12094 -0,70992 -7,2254 -4,81881 -6,43369 0,975649 0,988238 NCI_ErbB4_signaling_events_Main_Pathway -0,32819 -0,21876 -0,3352 -3,45184 -2,89838 -2,24904 -0,76454 -0,75446 -1,26493 0,442553 0,11316 0,361333 0,245676 0,140668 0,494842 -5,04118 -3,80649 -2,493 0,976183 0,988238 reactome_Synthesis_of_GDP_mannose_Main_Pat 0,08258 0,087708 0,074462 0,477713 0,208085 0,279123 -0,37324 -0,20905 -0,30167 -0,52391 -0,40977 -0,3153 -0,41222 -0,33361 -0,12574 0,501357 0,358612 0,336502 0,976182 0,988238 biocarta_lissencephaly_gene_lis1_in_neuronal_m 0,029444 0,034675 -0,00396 -0,73928 -1,53854 -0,32988 -0,1093 -0,05812 -0,3666 0,478425 0,227544 0,470782 0,174945 0,366496 0,350658 -1,3089 -1,02156 -1,38059 0,97825 0,989425 ERK_Signaling_Pathway_Translation 0,024113 0,100887 -0,14722 -0,43786 -0,28535 -0,31929 0,204473 0,150963 0,126164 -0,80448 0,587821 0,049351 -0,25085 -0,17915 -0,28886 -1,17448 -1,11836 -0,21098 0,978308 0,989425 reactome_IRS_activation_Main_Pathway 0,04143 -0,06728 -0,05155 0,49333 0,23686 -0,52988 -0,77644 -0,94326 -0,9352 1,015073 -0,36569 -0,96174 0,183375 0,261929 0,18598 0,607602 0,420952 0,670342 0,978153 0,989425 biocarta_g_protein_signaling_through_tubby_pro -0,21711 -0,13999 -0,09446 0,123964 1,314031 0,670475 -0,24599 -0,49388 -0,12754 0,915043 0,302978 -0,80297 -0,15238 0,289575 0,302289 1,531157 0,322674 1,920755 0,979798 0,98995 Cellular_Apoptosis_Pathway_Depolarization 0,03205 0,113157 0,005226 0,505627 -0,12593 0,493697 0,416678 0,441865 0,354458 0,517096 -0,02148 -0,09843 0,127128 0,211714 0,11927 0,584687 0,774338 0,123438 0,980222 0,98995 Chemokine_Pathway_Internalization_Degradation -0,00969 -0,34304 -0,14025 -0,15845 -0,09895 0,081383 -1,00347 -1,14768 -0,97531 -0,58112 -0,15065 -0,33544 -0,33531 -0,50969 -0,34014 -0,44982 0,486041 -0,55052 0,979598 0,98995 GABA_shunt 0,044306 -0,04622 -0,11706 -0,28694 -0,00347 -0,36021 0,313616 0,415341 0,271749 0,300822 0,692338 -0,93707 0,552547 0,094195 0,4226 -0,30956 0,483914 0,569947 0,979521 0,98995 methylglyoxal_degradation_VI -0,03319 -0,11033 -0,04313 0,160439 0,211542 0,09724 0,005883 0,020238 0,032729 0,044279 0,09738 -0,01646 -0,00191 0,152651 -0,02988 0,407441 0,408202 0,147749 0,980416 0,98995 reactome_Glycosphingolipid_metabolism_Main_P -0,40964 -0,48681 -0,02914 -0,2825 -1,07218 -1,12118 -5,55753 -4,72364 -5,34113 1,591497 0,045996 1,879735 -0,68779 -1,17679 0,244329 -2,24458 -3,76954 -2,8701 0,981167 0,990168 reactome_Synthesis_of_12_eicosatetraenoic_acid -0,10201 -0,15998 -0,10902 0,548093 0,377057 0,679177 -0,08709 -0,32012 0,059484 0,092688 0,438914 0,682349 -0,00243 -0,22202 -0,05156 0,575656 0,366319 0,168191 0,981267 0,990168 acyl-CoA_hydrolysis 0,092326 0,104646 0,02515 -0,11657 -0,06859 -0,11968 -1,13337 -1,11821 -1,2547 -0,3548 0,505079 -0,15648 -0,20756 -0,14312 -0,05588 -0,22337 -0,83109 -0,25427 0,982358 0,990894 NCI_Validated_transcriptional_targets_of_deltaNp 0,313138 -0,01297 0,204298 -0,14384 0,07736 -0,24269 0,470524 0,361748 0,503813 0,386872 0,956776 0,226101 0,23055 0,552449 0,730907 -0,16197 -0,30871 0,163803 0,982623 0,990894 biocarta_il_7_signal_transduction_Main_Pathway -0,06265 -0,04672 -0,10523 -0,39609 0,642933 0,206549 0,056738 0,112585 -0,13959 0,747508 0,201206 1,575801 0,252681 0,178494 0,508479 -0,24807 -0,10051 0,173928 0,983628 0,991586 NCI_Wnt_signaling_network_Main_Pathway -0,97037 -0,66132 -0,33522 0,267786 0,071332 -1,5489 -1,66385 -1,90616 -0,54644 -2,78545 -0,94159 -1,56484 -0,93499 0,261465 0,164658 1,119019 1,250827 2,424856 0,984052 0,991693 NCI_Ceramide_signaling_Main_Pathway 0,071716 -0,54768 -0,22183 -0,85502 -0,08054 -1,32406 -3,41366 -2,96465 -3,94028 -2,77238 -0,63929 3,026571 -0,44826 -0,41134 -0,27125 -1,87802 -1,72581 -0,49931 0,984929 0,991935 reactome_Unblocking_of_NMDA_receptor_glutam -0,13707 -0,09529 -0,0166 2,028428 2,71313 1,854021 -2,02825 -1,93196 -1,85608 1,314716 1,010402 -0,59063 0,17143 0,150568 0,154184 2,687146 3,246715 3,310922 0,984711 0,991935 L-serine_degradation -0,03695 -0,06273 -0,04574 -0,02682 0,056502 -0,06386 -0,22188 -0,22772 -0,25287 -0,21267 0,047587 -0,05965 0,074775 0,135821 0,197787 0,339588 0,265046 0,314682 0,986251 0,992945 NCI_Endothelins_Pathway_(cAMP_biosynthetic_p -0,19234 -0,24665 -0,18794 -0,37801 -0,62867 -1,85419 -2,63482 -2,30303 -2,51322 -0,49019 -0,64281 -0,32714 0,972228 1,076067 1,284795 0,91315 0,456373 1,511394 0,986929 0,992985 reactome_HSF1_activation_Main_Pathway -0,12156 -0,05689 -0,12855 -0,68683 -0,48141 -0,15593 1,023921 1,198888 1,073257 0,555355 0,247292 0,183096 0,09144 -0,18504 -0,04745 -1,14914 -0,76625 -0,99594 0,986824 0,992985 NCI_Arf6_downstream_Pathway_(actin_filament_ 0,023558 -0,07546 -0,04222 -0,18706 -0,36513 0,012308 0,151889 0,096177 0,062623 -0,34629 -0,51731 -0,26716 0,22184 0,202798 0,066586 0,447237 0,396682 0,286762 0,987367 0,993106 1D-imyoi-inositol_hexakisphosphate_biosynthesis 0,0289 -0,19052 -0,04979 -0,39228 -0,42462 0,495781 -1,31197 -1,27251 -1,90917 1,456699 0,178427 -0,09736 -0,28805 0,122679 -0,78301 -1,03356 -1,14157 -1,0112 0,988204 0,993626 NCI_ErbB2_ErbB3_signaling_events_Pathway_(he 0,143909 -0,07851 -0,02687 -0,1152 -0,07687 -0,66189 -0,59562 -0,48172 -0,87668 0,567443 0,973238 0,887422 0,11577 0,234141 0,214049 -1,30634 -1,0161 -0,61591 0,989414 0,993881 NCI_ErbB2_ErbB3_signaling_events_Pathway_(ma 0,143909 -0,07851 -0,02687 -0,1152 -0,07687 -0,66189 -0,59562 -0,48172 -0,87668 0,567443 0,973238 0,887422 0,11577 0,234141 0,214049 -1,30634 -1,0161 -0,61591 0,989414 0,993881 NCI_ErbB2_ErbB3_signaling_events_Pathway_(ne 0,143909 -0,07851 -0,02687 -0,1152 -0,07687 -0,66189 -0,59562 -0,48172 -0,87668 0,567443 0,973238 0,887422 0,11577 0,234141 0,214049 -1,30634 -1,0161 -0,61591 0,989414 0,993881 reactome_Hexose_uptake_Main_Pathway 0,06702 0,126892 0,120883 0,474192 -0,81796 -0,03322 0,388037 0,30372 1,059473 -1,35672 -0,29618 -0,82524 0,203111 0,028706 -0,00088 0,99916 0,482695 0,431092 0,990786 0,994938 KEGG_Inflammatory_bowel_disease_IBD__Main_ -0,046 -0,31475 -0,18413 -1,88025 0,172371 -0,08911 -1,45256 -1,37169 -1,42587 1,18488 -0,8571 1,156209 0,226441 -0,66523 0,216114 -1,01092 -1,69846 -1,30797 0,991131 0,994964 NCI_Alpha4_beta1_integrin_signaling_events_Pat 0,008081 -0,12858 -0,14161 -0,52811 -0,94558 -0,39841 -0,8763 -0,66451 -1,03405 0,549407 0,509751 0,826326 -0,42673 -0,00505 -0,2381 -2,41088 -1,69487 -1,3667 0,992148 0,99554 NCI_Class_IB_PI3K_non_lipid_kinase_events_Path -0,07086 0,001065 0,002224 0,223478 -0,46504 0,111787 0,224278 0,207324 0,348193 0,22125 0,202478 -0,32903 -0,22508 0,226034 0,108009 -0,31768 0,175488 0,071997 0,992344 0,99554 reactome_HS_GAG_degradation_Main_Pathway -0,38685 -0,17624 -0,27962 -0,36603 -0,68981 -0,15186 0,512096 0,247602 0,49684 -1,15449 -0,42799 -1,5206 0,54853 -0,11856 -0,15737 1,646714 0,400605 0,475398 0,99497 0,997853 biocarta_il_7_signal_transduction_Pathway_(cell_ -0,00631 0,180577 0,039349 -0,92668 0,053686 -0,34233 0,484717 0,516633 0,674298 -0,41761 0,17625 0,29385 0,305783 0,355848 0,577647 -0,27389 0,027985 0,006061 0,99654 0,998784 NCI_Class_I_PI3K_signaling_events_Pathway_(act -0,07927 0,071653 -0,10765 -0,24108 -0,10482 -0,06898 0,303519 0,277083 0,123498 0,585046 0,707789 0,110008 -0,9281 0,106482 0,002167 -1,95982 -0,87332 -0,31873 0,996397 0,998784 reactome_Regulation_of_gene_expression_in_en -0,03565 0,115786 0,010587 0,334446 0,036727 0,007012 0,003534 -0,08526 0,16579 0,02197 -0,19045 0,047516 -0,05814 0,225776 0,063933 0,432968 0,087159 0,421944 0,99733 0,999254 NCI_Circadian_rhythm_Main_Pathway 0,10336 0,086481 0,071425 0,646715 0,69634 -0,15441 0,545963 0,735957 0,322307 0,279055 0,631457 0,190671 -0,29819 -0,23995 0,021657 -0,36246 -0,20266 0,21312 0,999083 0,999404 NCI_Circadian_rhythm_Pathway_(chromatin_mod 0,10336 0,086481 0,071425 0,646715 0,69634 -0,15441 0,545963 0,735957 0,322307 0,279055 0,631457 0,190671 -0,29819 -0,23995 0,021657 -0,36246 -0,20266 0,21312 0,999083 0,999404 NCI_Circadian_rhythm_Pathway_(S_phase_of_mi 0,10336 0,086481 0,071425 0,646715 0,69634 -0,15441 0,545963 0,735957 0,322307 0,279055 0,631457 0,190671 -0,29819 -0,23995 0,021657 -0,36246 -0,20266 0,21312 0,999083 0,999404 NCI_ErbB1_downstream_signaling_Pathway_(cell 0,064515 0,135104 0,074536 -0,51627 -0,48765 -0,89093 -0,62129 -0,56396 -0,73758 -0,95979 -0,27471 -0,73117 0,034426 0,102865 0,151688 -0,36673 -0,39486 0,048033 0,998513 0,999404 reactome_Ceramide_signalling_Main_Pathway -0,15672 -0,06915 0,010013 0,241426 0,388173 0,060582 -0,25718 -0,32307 -0,16227 0,762032 0,282954 0,100244 0,350108 0,063681 0,314156 0,476277 0,295291 0,42369 0,998055 0,999404 NCI_EPHB_forward_signaling_Main_Pathway -0,18775 -0,33926 -0,40159 0,934522 0,111925 0,668282 -1,76163 -1,66931 -1,73563 0,743204 0,07886 -0,41669 -0,38598 -0,1421 0,018016 0,52251 0,850664 0,956388 0,999795 0,999795 alanine_biosynthesisdegradation 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA aspartate_biosynthesis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA fructose_26-bisphosphate_synthesisdephosphory 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA glycerol-3-phosphate_shuttle 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA glycine_cleavage 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA glycineserine_biosynthesis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA ILK_Signaling_Pathway_Regulation_of_Intermedia 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA lactate_fermentation_reoxidation_of_cytosolic_N 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA p38_Signaling_Pathway_Apoptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA reactome_Formation_of_ATP_by_chemiosmotic_ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA reactome_XBP1_S_activates_chaperone_genes_M 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NA NA