DOCSLIB.ORG

Min Inten WT Inten GB Acc

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Min Inten WT Inten GB Acc Min_inten WT_inten GB_acc TIGR_TC Role_guess UniGene 132203 123010 AF159801 null null null 13508 17609 AF159803 null null null 52333 20136 X58149 null null null 75866 73547 U91966 null null null 148532 344853 AF168390 null null null 848119 272422 AF247559 null null null 326947 316932 X56062 null null null 67930 214658 AF198054 null null null 0 0 AI838353 TC190235 null Mm.20332 29943 25863 AI835341 TC159795 null Mm.34246 3997 6702 AI836148 TC162029 null Mm.21814 24732 22620 AI835376 TC160090 epididymal secretory protein Mm.29454 0 0 AI835491 TC205226 null Mm.31336 0 0 AI835355 TC205891 null Mm.22978 25853 45514 AI836154 TC187501 eIF3-p44 Mm.30080 0 0 AI835382 TC201576 paralemmin Mm.34650 30669 54630 AI836959 TC201177 null Mm.3037 28292 31475 AI837008 TC204328 ARF5 null 0 0 AI838477 TC192401 null Mm.23175 0 0 AI836065 null null Mm.39117 0 0 AI836968 TC200144 alpha-actinin Mm.29991 5408 7144 AI838420 TC200460 null Mm.22577 0 0 AI835993 null null null 0 0 AI836072 null null Mm.39118 163905 163004 AF159801 null null null 8211 11955 AF159803 null null null 0 0 X58149 null null null 161961 153239 U91966 null null null 203208 479592 AF168390 null null null 1037095 355828 AF247559 null null null 580867 604084 X56062 null null null 546563 1709116 AF198054 null null null 13013 20749 AI835524 TC201674 null Mm.20274 111206 124762 AI835727 TC174086 null Mm.28018 250404 267750 AI835907 TC173186 non-muscle myosin light chain Mm.3328 45759 47259 AI835957 TC203042 null Mm.41188 5756 17132 AI835546 TC161790 TDAG51 Mm.3117 55826 48185 AI835745 TC170501 null Mm.41141 0 0 AI835920 TC162571 I47 Mm.4884 0 0 AI835964 TC175052 null Mm.6793 9698 10013 AI836095 TC176694 null Mm.41814 15609 17687 AI836772 null null Mm.39123 183509 198586 AI836804 TC159832 proteasome subunit C2 Mm.30097 158705 140018 AI836827 TC188337 null Mm.28712 49978 55696 AI836101 TC186934 cyclin I Mm.22711 7385 13260 AI840315 TC203506 platelet glycoprotein Ib beta Mm.20365 0 0 AI836811 TC204903 null Mm.40058 36818 56235 AI840336 TC175959 null Mm.41536 37280 32275 AF159801 null null null 11046 19045 AF159803 null null null 104765 35350 X58149 null null null 101979 98025 U91966 null null null 112784 286359 AF168390 null null null 509747 175148 AF247559 null null null 157078 165715 X56062 null null null 9443 20723 AF198054 null null null 0 0 AI836342 TC190970 mHuC-L Mm.3477 72602 92420 AI835344 TC173682 null Mm.28725 0 0 AI836149 null null null 51342 53248 AI835377 TC174101 null Mm.30028 21920 28635 AI835492 TC199927 null Mm.31435 0 0 AI835986 null null null 0 0 AI835572 TC192055 null Mm.40192 329717 362213 AI835385 TC159810 lactate dehydrogenase Mm.26504 28282 47998 AI836960 null null Mm.41872 187806 167680 AI837011 TC200930 phosphatidylinositol transfer Mm.3128 7193 5346 AI838479 TC173884 null null 17432 22970 AI836066 TC174782 Nucleosome assembly protein 1- Mm.2831 0 0 AI836973 TC164754 null Mm.40311 58388 69394 AI838428 null null Mm.40763 0 0 AI835995 TC177825 null Mm.23114 0 0 AI836074 TC165075 null Mm.44094 140283 136102 AF159801 null null null 21182 32116 AF159803 null null null 122197 41631 X58149 null null null 925646 912923 U91966 null null null 240964 577802 AF168390 null null null 1111702 378274 AF247559 null null null 292558 303394 X56062 null null null 815852 2420349 AF198054 null null null 11613 8326 AI835528 TC162980 null Mm.34412 55197 78980 AI835731 TC186637 ryudocan core protein Mm.3815 167557 300630 AI835909 TC159537 ribosomal protein S3 Mm.4696 23500 24082 AI835958 TC162231 null Mm.3445 11263 13910 AI835548 TC176486 null Mm.36523 56982 61741 AI835749 null null null 11146 10628 AI835922 TC157991 null Mm.35707 21763 21082 AI835965 TC160681 null Mm.22353 0 0 AI836096 TC177835 glial fibrillary acidic protei Mm.5716 99652 133862 AI840311 null null Mm.40098 3831 6016 AI840324 TC205803 null Mm.40741 86682 79748 AI836829 TC174656 protein kinase type II regulat Mm.27046 0 0 AI836102 TC191755 null Mm.44232 662887 583662 AI840316 null null null 136852 227611 AI840326 null null Mm.42960 6437 5536 AI840337 null null null 98347 95241 AF159801 null null null 10752 12228 AF159803 null null null 16284 6002 X58149 null null null 245379 229930 U91966 null null null 248576 570233 AF168390 null null null 1041328 361483 AF247559 null null null 414461 417588 X56062 null null null 64062 219976 AF198054 null null null 12814 9647 AI836344 TC161427 null Mm.28160 33955 64696 AI835983 TC163662 null Mm.11346 20434 22645 AI836151 TC161911 null Mm.28164 9654 14934 AI835378 TC178410 null Mm.41362 0 0 AI836349 TC190365 null Mm.6144 63653 79553 AI835359 TC158858 null Mm.25393 67525 61437 AI835575 null null Mm.39111 4331 9929 AI835386 TC209382 null Mm.44621 0 0 AI836962 null null null 34868 32967 AI838406 null null null 8306 3609 AI838481 TC160809 null Mm.21881 11414 12079 AI836067 TC188246 Fus1 protein Mm.21739 41098 39671 AI836976 TC200179 glutamate dehydrogenase (NAD(P Mm.10600 0 0 AI838424 null null Mm.40404 0 0 AI835996 TC178862 null Mm.40738 9526 9470 AI836075 TC158909 Ypt1 protein (AA 1-205) Mm.14530 41430 40584 AF159801 null null null 5289 12256 AF159803 null null null 10335 13173 X58149 null null null 175140 165554 U91966 null null null 101673 232188 AF168390 null null null 532017 165349 AF247559 null null null 211388 189786 X56062 null null null 394020 1178394 AF198054 null null null 26385 26348 AI835531 TC188455 null Mm.41558 45607 43700 AI835733 TC161019 small zinc finger-like protein Mm.22201 247262 309427 AI835910 TC159548 calmodulin Mm.18041 54672 63562 AI835959 TC174431 null Mm.30184 0 0 AI835551 TC202066 null null 133811 147688 AI835750 TC163683 null Mm.41359 92763 100795 AI835924 TC200741 signal recognition particle su Mm.2233 72405 97083 AI835967 TC201195 arylhydrocarbon receptor Mm.4452 90890 95707 AI836097 null null Mm.40053 11580 9348 AI836774 TC175173 null Mm.27520 0 0 AI836807 TC174649 null Mm.39985 136370 76296 AI836830 TC158441 bisphosphate 3'-nucleotidase Mm.18096 6876 8239 AI836104 TC175373 intracellular hyaluronan-bindi Mm.40989 0 0 AI836782 TC202829 neuroglycan C Mm.38496 3284 5639 AI840328 null null Mm.41299 19631 24175 AI836837 TC162145 voltage-dependent calcium chan Mm.3544 177631 164115 AF159801 null null null 24133 21227 AF159803 null null null 290255 89535 X58149 null null null 123033 102617 U91966 null null null 257366 543177 AF168390 null null null 1276670 416226 AF247559 null null null 529267 469156 X56062 null null null 182450 530712 AF198054 null null null 84711 82814 AI836346 TC174088 null Mm.28018 270233 368648 AI835347 TC159944 tropomyosin 5 Mm.17306 17783 24850 AI836152 TC175329 null Mm.22189 26309 27420 AI835379 TC175706 cancer associated surface anti Mm.41436 0 0 AI835314 TC177502 cyclin dependent kinase 5 regu Mm.136 36270 31580 AI835361 TC188923 c-fms protein precursor (AA -1 Mm.22574 0 0 AI835576 TC191333 null Mm.39312 0 0 AI836170 TC187670 MYLE protein Mm.41091 0 0 AI836964 TC201336 GS15 Mm.34315 8750 8839 AI838407 null null Mm.15571 14356 20294 AI838482 TC173504 HP1 alpha protein Mm.28003 52386 51098 AI836068 null null Mm.39762 0 0 AI836977 TC173556 null Mm.542 6033 2584 AI838435 TC190041 null Mm.34087 0 0 AI835998 TC187718 cbp37 Mm.22327 3015 4457 AI836076 TC162982 vesicular inhibitory amino aci Mm.7444 225755 191385 AF159801 null null null 16921 26542 AF159803 null null null 74922 21080 X58149 null null null 776846 637392 U91966 null null null 250067 538991 AF168390 null null null 1047499 368812 AF247559 null null null 456468 417444 X56062 null null null 862899 2580131 AF198054 null null null 37565 41426 AI835541 TC203165 null Mm.40601 6458 11167 AI835735 TC170503 null Mm.40733 17717 20691 AI835916 TC187105 null Mm.42949 13985 19766 AI835960 null null Mm.38994 14729 16658 AI835555 TC204762 null Mm.39311 29006 31840 AI835751 TC175971 unnamed protein product Mm.44229 466969 741987 AI835929 TC199907 elongation factor 2 Mm.4968 28798 45104 AI835968 TC160224 null Mm.3069 185102 168240 AI836098 null null null 377508 385496 AI840312 null null null 113398 92737 AI840325 TC186490 null Mm.16783 83663 73081 AI840335 null null Mm.39154 15927 20812 AI836106 TC188187 null Mm.18819 285389 354752 AI836784 TC173371 HRS Mm.43331 164450 130692 AI840329 null null Mm.9621 39462 35123 AI836839 TC175398 null Mm.41420 296431 257524 AF159801 null null null 81121 85111 AF159803 null null null 88147 30704 X58149 null null null 284694 243245 U91966 null null null 415954 833744 AF168390 null null null 1244382 383488 AF247559 null null null 705035 616576 X56062 null null null 674017 1754609 AF198054 null null null 130558 206681 AI836347 TC159528 alpha-tubulin Mm.4591 24645 36176 AI835353 TC176027 serine/threonine protein kinas Mm.2981 77227 87905 AI836153 TC187239 null Mm.28286 460152 266168 AI835380 TC173404 succinate dehydrogenase Ip sub Mm.29141 229819 315901 AI835315 TC200132 null Mm.22723 21858 34726 AI835371 TC161008 Msx-interacting-zinc finger pr Mm.42495 0 0 AI836158 TC162492 E2F-5 Mm.379 8038 18994 AI835388 TC174483 null Mm.24652 23855 13035 AI836965 TC173553 Mlark Mm.542 57804 62912 AI838412 TC186991 null Mm.27818 8801 11233 AI835990 TC189380 null Mm.41580 279669 300989 AI836069 null null null 20866 19608 AI836978 TC189951 HCNGP Mm.3899 6469 5666 AI838436 TC186653 peroxisomal membrane protein 2 Mm.30215 0 0 AI835999 TC196189 null Mm.67028 0 0 AI836077 TC188760 null Mm.38347 98649 93961 AF159801 null null null 35561 50386 AF159803 null null null 496850 177921 X58149 null null null 899258 932817 U91966 null null null 259480 634033 AF168390 null null null 1834954 691756 AF247559 null null null 745303 764200 X56062 null null null 959344 2721214 AF198054 null null
Load more

Recommended publications
  • Characterization of Nudix Hydrolases: a Utilitarian
    CHARACTERIZATION OF NUDIX HYDROLASES: A UTILITARIAN SUPERFAMILY OF ENZYMES By Andres Hernandez de la Peña A dissertation submitted to the Johns Hopkins University in conformity with the requirements for the degree of Doctor of Philosophy Baltimore, Maryland August, 2015 Abstract The present work details the structural and enzymatic characterization of Nudix hydrolases from three different organisms – Bdellovibrio bacteriovorus, Mycobacterium tuberculosis, and Tetrahymena thermophila. Each of these Nudix enzymes presents unique questions about their physiological function within their organism which are answered with a combination of structural biology, genetic manipulation, enzyme kinetics, and a wide range of protein assays. We demonstrate that RenU, from M. tuberculosis, is part of Redox Homeostasis Control System (RHOCS), which senses and regulates NADH concentrations. This control systems involves two other proteins, the serine/threonine protein kinase G (pknG) and the L13 ribosomal subunits, without which the bacterium fails to evade lysosomal delivery and falls prey to the oxidative arsenal of the macrophage host. Bd-NDPSase, a Nudix enzyme encoded by the B. bacteriovorus gene BD3179, localizes to the periplasmic space of the bacterium and hydrolyses at least four nucleoside diphosphate sugars in vitro. Through atomic-resolution models from X-ray diffraction, we identified a motif that differentiates this hydrolase from the similar, but more substrate specific, ADP- ribose hydrolase from E. coli. Lastly, we show that Nud1p from T. thermophila is a member of the Ezl1p complex, the histone methyltransferase Polycomb Group homologue of this protozoan. With the use of in vitro enzymatic assays we show, in addition, that Nu1dp hydrolyses CoA preferentially over acetyl-CoA and other nucleoside derivatives.
    [Show full text]
  • Association of Gene Ontology Categories with Decay Rate for Hepg2 Experiments These Tables Show Details for All Gene Ontology Categories
    Supplementary Table 1: Association of Gene Ontology Categories with Decay Rate for HepG2 Experiments These tables show details for all Gene Ontology categories. Inferences for manual classification scheme shown at the bottom. Those categories used in Figure 1A are highlighted in bold. Standard Deviations are shown in parentheses. P-values less than 1E-20 are indicated with a "0". Rate r (hour^-1) Half-life < 2hr. Decay % GO Number Category Name Probe Sets Group Non-Group Distribution p-value In-Group Non-Group Representation p-value GO:0006350 transcription 1523 0.221 (0.009) 0.127 (0.002) FASTER 0 13.1 (0.4) 4.5 (0.1) OVER 0 GO:0006351 transcription, DNA-dependent 1498 0.220 (0.009) 0.127 (0.002) FASTER 0 13.0 (0.4) 4.5 (0.1) OVER 0 GO:0006355 regulation of transcription, DNA-dependent 1163 0.230 (0.011) 0.128 (0.002) FASTER 5.00E-21 14.2 (0.5) 4.6 (0.1) OVER 0 GO:0006366 transcription from Pol II promoter 845 0.225 (0.012) 0.130 (0.002) FASTER 1.88E-14 13.0 (0.5) 4.8 (0.1) OVER 0 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism3004 0.173 (0.006) 0.127 (0.002) FASTER 1.28E-12 8.4 (0.2) 4.5 (0.1) OVER 0 GO:0006357 regulation of transcription from Pol II promoter 487 0.231 (0.016) 0.132 (0.002) FASTER 6.05E-10 13.5 (0.6) 4.9 (0.1) OVER 0 GO:0008283 cell proliferation 625 0.189 (0.014) 0.132 (0.002) FASTER 1.95E-05 10.1 (0.6) 5.0 (0.1) OVER 1.50E-20 GO:0006513 monoubiquitination 36 0.305 (0.049) 0.134 (0.002) FASTER 2.69E-04 25.4 (4.4) 5.1 (0.1) OVER 2.04E-06 GO:0007050 cell cycle arrest 57 0.311 (0.054) 0.133 (0.002)
    [Show full text]
  • Growth and Gene Expression Profile Analyses of Endometrial Cancer Cells Expressing Exogenous PTEN
    [CANCER RESEARCH 61, 3741–3749, May 1, 2001] Growth and Gene Expression Profile Analyses of Endometrial Cancer Cells Expressing Exogenous PTEN Mieko Matsushima-Nishiu, Motoko Unoki, Kenji Ono, Tatsuhiko Tsunoda, Takeo Minaguchi, Hiroyuki Kuramoto, Masato Nishida, Toyomi Satoh, Toshihiro Tanaka, and Yusuke Nakamura1 Laboratories of Molecular Medicine [M. M-N., M. U., K. O., T. M., T. Ta., Y. N.] and Genome Database [T. Ts.], Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; Department of Obstetrics and Gynecology, School of Medicine, Kitasato University, Sagamihara 228-8555, Japan [H. K.]; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305-8576, Japan [M. N.]; and Department of Obstetrics and Gynecology, Ibaraki Seinan Central Hospital, Tsukuba 306-0433, Japan [T. S.] ABSTRACT Akt/protein kinase B, cell survival, and cell proliferation (8). Over- expression of PTEN can decrease cell proliferation and tumorigenicity The PTEN tumor suppressor gene encodes a multifunctional phospha- (9, 10), an observation attributed to the ability of PTEN to induce cell tase that plays an important role in inhibiting the phosphatidylinositol-3- cycle arrest and apoptosis (11, 12). kinase pathway and downstream functions that include activation of Akt/protein kinase B, cell survival, and cell proliferation. Enforced ex- Thus, lack of PTEN expression may affect a complex set of pression of PTEN in various cancer cell lines decreases cell proliferation transcriptional targets. However, no systematic assessment of PTEN- through arrest of the cell cycle, accompanied in some cases by induction regulated targets in cancer cells has been reported to date.
    [Show full text]
  • Generated by SRI International Pathway Tools Version 25.0, Authors S
    Authors: Pallavi Subhraveti Ron Caspi Quang Ong Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000725805Cyc: Streptomyces xanthophaeus Cellular Overview Connections between pathways are omitted for legibility.
    [Show full text]
  • (10) Patent No.: US 8119385 B2
    US008119385B2 (12) United States Patent (10) Patent No.: US 8,119,385 B2 Mathur et al. (45) Date of Patent: Feb. 21, 2012 (54) NUCLEICACIDS AND PROTEINS AND (52) U.S. Cl. ........................................ 435/212:530/350 METHODS FOR MAKING AND USING THEMI (58) Field of Classification Search ........................ None (75) Inventors: Eric J. Mathur, San Diego, CA (US); See application file for complete search history. Cathy Chang, San Diego, CA (US) (56) References Cited (73) Assignee: BP Corporation North America Inc., Houston, TX (US) OTHER PUBLICATIONS c Mount, Bioinformatics, Cold Spring Harbor Press, Cold Spring Har (*) Notice: Subject to any disclaimer, the term of this bor New York, 2001, pp. 382-393.* patent is extended or adjusted under 35 Spencer et al., “Whole-Genome Sequence Variation among Multiple U.S.C. 154(b) by 689 days. Isolates of Pseudomonas aeruginosa” J. Bacteriol. (2003) 185: 1316 1325. (21) Appl. No.: 11/817,403 Database Sequence GenBank Accession No. BZ569932 Dec. 17. 1-1. 2002. (22) PCT Fled: Mar. 3, 2006 Omiecinski et al., “Epoxide Hydrolase-Polymorphism and role in (86). PCT No.: PCT/US2OO6/OOT642 toxicology” Toxicol. Lett. (2000) 1.12: 365-370. S371 (c)(1), * cited by examiner (2), (4) Date: May 7, 2008 Primary Examiner — James Martinell (87) PCT Pub. No.: WO2006/096527 (74) Attorney, Agent, or Firm — Kalim S. Fuzail PCT Pub. Date: Sep. 14, 2006 (57) ABSTRACT (65) Prior Publication Data The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides US 201O/OO11456A1 Jan. 14, 2010 encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides.
    [Show full text]
  • The Microbiota-Produced N-Formyl Peptide Fmlf Promotes Obesity-Induced Glucose
    Page 1 of 230 Diabetes Title: The microbiota-produced N-formyl peptide fMLF promotes obesity-induced glucose intolerance Joshua Wollam1, Matthew Riopel1, Yong-Jiang Xu1,2, Andrew M. F. Johnson1, Jachelle M. Ofrecio1, Wei Ying1, Dalila El Ouarrat1, Luisa S. Chan3, Andrew W. Han3, Nadir A. Mahmood3, Caitlin N. Ryan3, Yun Sok Lee1, Jeramie D. Watrous1,2, Mahendra D. Chordia4, Dongfeng Pan4, Mohit Jain1,2, Jerrold M. Olefsky1 * Affiliations: 1 Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California, USA. 2 Department of Pharmacology, University of California, San Diego, La Jolla, California, USA. 3 Second Genome, Inc., South San Francisco, California, USA. 4 Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA. * Correspondence to: 858-534-2230, [email protected] Word Count: 4749 Figures: 6 Supplemental Figures: 11 Supplemental Tables: 5 1 Diabetes Publish Ahead of Print, published online April 22, 2019 Diabetes Page 2 of 230 ABSTRACT The composition of the gastrointestinal (GI) microbiota and associated metabolites changes dramatically with diet and the development of obesity. Although many correlations have been described, specific mechanistic links between these changes and glucose homeostasis remain to be defined. Here we show that blood and intestinal levels of the microbiota-produced N-formyl peptide, formyl-methionyl-leucyl-phenylalanine (fMLF), are elevated in high fat diet (HFD)- induced obese mice. Genetic or pharmacological inhibition of the N-formyl peptide receptor Fpr1 leads to increased insulin levels and improved glucose tolerance, dependent upon glucagon- like peptide-1 (GLP-1). Obese Fpr1-knockout (Fpr1-KO) mice also display an altered microbiome, exemplifying the dynamic relationship between host metabolism and microbiota.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9,689,046 B2 Mayall Et Al
    USOO9689046B2 (12) United States Patent (10) Patent No.: US 9,689,046 B2 Mayall et al. (45) Date of Patent: Jun. 27, 2017 (54) SYSTEM AND METHODS FOR THE FOREIGN PATENT DOCUMENTS DETECTION OF MULTIPLE CHEMICAL WO O125472 A1 4/2001 COMPOUNDS WO O169245 A2 9, 2001 (71) Applicants: Robert Matthew Mayall, Calgary (CA); Emily Candice Hicks, Calgary OTHER PUBLICATIONS (CA); Margaret Mary-Flora Bebeselea, A. et al., “Electrochemical Degradation and Determina Renaud-Young, Calgary (CA); David tion of 4-Nitrophenol Using Multiple Pulsed Amperometry at Christopher Lloyd, Calgary (CA); Lisa Graphite Based Electrodes', Chem. Bull. “Politehnica” Univ. Kara Oberding, Calgary (CA); Iain (Timisoara), vol. 53(67), 1-2, 2008. Fraser Scotney George, Calgary (CA) Ben-Yoav. H. et al., “A whole cell electrochemical biosensor for water genotoxicity bio-detection”. Electrochimica Acta, 2009, 54(25), 6113-6118. (72) Inventors: Robert Matthew Mayall, Calgary Biran, I. et al., “On-line monitoring of gene expression'. Microbi (CA); Emily Candice Hicks, Calgary ology (Reading, England), 1999, 145 (Pt 8), 2129-2133. (CA); Margaret Mary-Flora Da Silva, P.S. et al., “Electrochemical Behavior of Hydroquinone Renaud-Young, Calgary (CA); David and Catechol at a Silsesquioxane-Modified Carbon Paste Elec trode'. J. Braz. Chem. Soc., vol. 24, No. 4, 695-699, 2013. Christopher Lloyd, Calgary (CA); Lisa Enache, T. A. & Oliveira-Brett, A. M., "Phenol and Para-Substituted Kara Oberding, Calgary (CA); Iain Phenols Electrochemical Oxidation Pathways”, Journal of Fraser Scotney George, Calgary (CA) Electroanalytical Chemistry, 2011, 1-35. Etesami, M. et al., “Electrooxidation of hydroquinone on simply prepared Au-Pt bimetallic nanoparticles'. Science China, Chem (73) Assignee: FREDSENSE TECHNOLOGIES istry, vol.
    [Show full text]
  • Supplementary Informations SI2. Supplementary Table 1
    Supplementary Informations SI2. Supplementary Table 1. M9, soil, and rhizosphere media composition. LB in Compound Name Exchange Reaction LB in soil LBin M9 rhizosphere H2O EX_cpd00001_e0 -15 -15 -10 O2 EX_cpd00007_e0 -15 -15 -10 Phosphate EX_cpd00009_e0 -15 -15 -10 CO2 EX_cpd00011_e0 -15 -15 0 Ammonia EX_cpd00013_e0 -7.5 -7.5 -10 L-glutamate EX_cpd00023_e0 0 -0.0283302 0 D-glucose EX_cpd00027_e0 -0.61972444 -0.04098397 0 Mn2 EX_cpd00030_e0 -15 -15 -10 Glycine EX_cpd00033_e0 -0.0068175 -0.00693094 0 Zn2 EX_cpd00034_e0 -15 -15 -10 L-alanine EX_cpd00035_e0 -0.02780553 -0.00823049 0 Succinate EX_cpd00036_e0 -0.0056245 -0.12240603 0 L-lysine EX_cpd00039_e0 0 -10 0 L-aspartate EX_cpd00041_e0 0 -0.03205557 0 Sulfate EX_cpd00048_e0 -15 -15 -10 L-arginine EX_cpd00051_e0 -0.0068175 -0.00948672 0 L-serine EX_cpd00054_e0 0 -0.01004986 0 Cu2+ EX_cpd00058_e0 -15 -15 -10 Ca2+ EX_cpd00063_e0 -15 -100 -10 L-ornithine EX_cpd00064_e0 -0.0068175 -0.00831712 0 H+ EX_cpd00067_e0 -15 -15 -10 L-tyrosine EX_cpd00069_e0 -0.0068175 -0.00233919 0 Sucrose EX_cpd00076_e0 0 -0.02049199 0 L-cysteine EX_cpd00084_e0 -0.0068175 0 0 Cl- EX_cpd00099_e0 -15 -15 -10 Glycerol EX_cpd00100_e0 0 0 -10 Biotin EX_cpd00104_e0 -15 -15 0 D-ribose EX_cpd00105_e0 -0.01862144 0 0 L-leucine EX_cpd00107_e0 -0.03596182 -0.00303228 0 D-galactose EX_cpd00108_e0 -0.25290619 -0.18317325 0 L-histidine EX_cpd00119_e0 -0.0068175 -0.00506825 0 L-proline EX_cpd00129_e0 -0.01102953 0 0 L-malate EX_cpd00130_e0 -0.03649016 -0.79413596 0 D-mannose EX_cpd00138_e0 -0.2540567 -0.05436649 0 Co2 EX_cpd00149_e0
    [Show full text]
  • Investigation of Two Early Events in Amyotrophic Lateral Sclerosis
    INVESTIGATION OF TWO EARLY EVENTS IN AMYOTROPHIC LATERAL SCLEROSIS -MRNA OXIDATION AND UP-REGULATION OF A NOVEL PROTECTIVE FACTOR MSUR1 DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Yueming Chang, Bachelor in Medicine *********** The Ohio State University 2007 Dissertation Committee: Approved by Professor Chien-liang Glenn Lin, Advisor Professor Andrej Rotter ------------------------------------------- Professor Arthur H.M. Burghes Advisor Professor John Oberdick The Ohio State Biochemistry Program ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive degeneration of motor neurons in the spinal cord, motor cortex and brainstem, which typically results in mortality within 2-5 years after the onset of disease. The cause of disease is unknown in the majority of cases, and there is no cure for ALS of the moment. Approximately 5% of ALS cases are familial, and 15-25% of the familial cases are linked to mutation in the gene encoding the antioxidant enzyme Cu 2+ /Zn 2+ superoxide dismutase (SOD1). Overexpression of some of ALS-linked mutant SOD1 proteins in transgenic mice results in the development of a neurological disorder that resembles ALS patients. The transgenic mice expressing mutant SOD1 (G93A) is a commonly used ALS animal model. This dissertation demonstrates two early events occurred in the pre-symptomatic stage of SOD1 (G93A) mice, including RNA oxidation and up-regulation of a novel protective factor MSUR1 (mutant SOD1-upregulated RNA 1). Accumulating evidence indicates that messenger RNA (mRNA) oxidation may be associated with neuronal deterioration during the process of neurodegeneration.
    [Show full text]
  • Papadaki Et Al., 2009 Supplementary
    Papadaki et al., 2009 Supplementary Supplemental Data Index x Supplemental Figures 1-6 x Supplemental Tables 1a, 1b, 2 Papadaki et al., 2009 Supplementary Supplemental Figure 1. Thymocyte restricted inactivation of the Elavl1 locus. + fl (A) Diagrammatic representation of the wild-type (Elavl1P P), floxed (Elavl1P P) and Cre- - recombined (Elavl1P P) Elavl1/HuR loci on mouse chromosome 8; Noted are the loxP sequences (triangles) flanking the selection marker (neo) used in gene targeting and the ATG containing exon 2 (white box); (H) denotes restriction sites for loci mapping. (B) Detection of native (+), targeted (fl) and Cre-recombinant (-) loci in thymocyte DNA extracts from control and test mice following HindIII digestion and Southern blotting. (C) Western blot of total thymic protein extracts probed with ĮHuR Ab + fl/fl indicating the loss of HuR protein in LckCreP PElavl1P P thymi. Į-actin is shown for quantitation. (D) Flow cytometric detection of intracellular mHuR protein in + fl/+ LckCreP PElavl1P P thymocytes (open histogram), and its respective loss in + fl/fl LckCreP PElavl1P P thymocytes (shaded histogram). The dotted histogram depicts the + isotype-matched background staining. (E) Flow cytometric detection of HuRP P or - + + + fl/+ HuRP P cells in gated splenic CD4P Por CD8P P T-cells from 8 week old LckCreP PElavl1P + fl/fl - Pand LckCreP PElavl1P P mice respectively. (F) Enumeration of HuRP P cells in + fl/fl LckCreP PElavl1P P thymocyte subsets and splenic T-cells; Data are percentages (+SEM) derived from the flow cytometric detection of HuR- cells in CD4/CD8/DP and DN gated populations (n=12-15) at 8-10 weeks of age.
    [Show full text]
  • A Unique Deoxyguanosine Triphosphatase Is Responsible For
    Proc. Nail. Acad. Sci. USA Vol. 85, pp. 2563-2567, April 1988 Biochemistry A unique deoxyguanosine triphosphatase is responsible for the OptAl phenotype of Escherichia coli (DNA replication/deoxyguanosine triphosphate/DNA binding protein/bacteriophage T7 gene 1.2 protein/tripolyphosphate) BENJAMIN B. BEAUCHAMP AND CHARLES C. RICHARDSON Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 Contributed by Charles C. Richardson, January 12, 1988 ABSTRACT Escherichia coli optAI, a mutant unable to type phage-infected cells. We have purified gene 1.2 protein support the growth of T7 phage containing mutations in gene to homogeneity from cells in which the cloned gene is 1.2, contains reduced amounts of dGTP. Extracts of E. coli overexpressed (8). Either gene 1.2 protein or dGTP restores optAl catalyze the hydrolysis of dGTP at a rate 50-fold greater DNA synthesis to extracts of E. coli optAl cells infected than do extracts of E. coli optA+ . The dGTPase responsible with T7 1.2 mutants (7, 8). Thus, the defect in DNA synthesis for the increased hydrolysis has been purified to apparent in optAl cells infected with T7 1.2 mutant phage is caused by homogeneity. Purification of the protein is facilitated by its a deficiency of dGTP in the optAl strain, a defect that is high affinity for single-stranded DNA. By using this purifica- overcome by the gene 1.2 protein. tion scheme an identical dGTPase has been purified from E. Can a deficiency in dGTP levels also explain the inability coli optA+. The purified proteins catalyze the hydrolysis of of T4 dexA and T4 CB120 mutants to grow on E.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2012/0266329 A1 Mathur Et Al
    US 2012026.6329A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0266329 A1 Mathur et al. (43) Pub. Date: Oct. 18, 2012 (54) NUCLEICACIDS AND PROTEINS AND CI2N 9/10 (2006.01) METHODS FOR MAKING AND USING THEMI CI2N 9/24 (2006.01) CI2N 9/02 (2006.01) (75) Inventors: Eric J. Mathur, Carlsbad, CA CI2N 9/06 (2006.01) (US); Cathy Chang, San Marcos, CI2P 2L/02 (2006.01) CA (US) CI2O I/04 (2006.01) CI2N 9/96 (2006.01) (73) Assignee: BP Corporation North America CI2N 5/82 (2006.01) Inc., Houston, TX (US) CI2N 15/53 (2006.01) CI2N IS/54 (2006.01) CI2N 15/57 2006.O1 (22) Filed: Feb. 20, 2012 CI2N IS/60 308: Related U.S. Application Data EN f :08: (62) Division of application No. 1 1/817,403, filed on May AOIH 5/00 (2006.01) 7, 2008, now Pat. No. 8,119,385, filed as application AOIH 5/10 (2006.01) No. PCT/US2006/007642 on Mar. 3, 2006. C07K I4/00 (2006.01) CI2N IS/II (2006.01) (60) Provisional application No. 60/658,984, filed on Mar. AOIH I/06 (2006.01) 4, 2005. CI2N 15/63 (2006.01) Publication Classification (52) U.S. Cl. ................... 800/293; 435/320.1; 435/252.3: 435/325; 435/254.11: 435/254.2:435/348; (51) Int. Cl. 435/419; 435/195; 435/196; 435/198: 435/233; CI2N 15/52 (2006.01) 435/201:435/232; 435/208; 435/227; 435/193; CI2N 15/85 (2006.01) 435/200; 435/189: 435/191: 435/69.1; 435/34; CI2N 5/86 (2006.01) 435/188:536/23.2; 435/468; 800/298; 800/320; CI2N 15/867 (2006.01) 800/317.2: 800/317.4: 800/320.3: 800/306; CI2N 5/864 (2006.01) 800/312 800/320.2: 800/317.3; 800/322; CI2N 5/8 (2006.01) 800/320.1; 530/350, 536/23.1: 800/278; 800/294 CI2N I/2 (2006.01) CI2N 5/10 (2006.01) (57) ABSTRACT CI2N L/15 (2006.01) CI2N I/19 (2006.01) The invention provides polypeptides, including enzymes, CI2N 9/14 (2006.01) structural proteins and binding proteins, polynucleotides CI2N 9/16 (2006.01) encoding these polypeptides, and methods of making and CI2N 9/20 (2006.01) using these polynucleotides and polypeptides.
    [Show full text]