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MRC Postdoctoral Fellow Medical Research Council Toxicology Unit MRC Postdoctoral Fellow Medical Research Council Toxicology Unit Closing Date: Monday 13th January 2020 Job Reference: PU21650 Reverse logo to go here Reverse logo to go here University of Cambridge www.cam.ac.uk The role Key responsibilities Salary: Research Write up research work, keeping Grade 7 accurate records for presentation and publication. £32,816-£40,322 The key responsibility is to undertake Manage own research and cutting edge research and be trained administrative activities, with within the areas of cancer biology guidance if required Contract: with a particular focus on p53-family. Problem Solving 3 Year Training Having completed a PhD, the post Programme The post holder will be expected to provide enthusiasm and the holder will be expected to have some of the skills and understanding to be intellectual energy necessary to able to act independently in solving Location: deliver their respective research research problems, many of which responsibilities and to play an active may require novel approaches. This Cambridge role in learning new skills. The role will require the integration of different will contribute to the overall aims and activities some of which will be supported by on the job training and successes of the research projects exposure to new disciplines so that Department: they take responsibility for within the the projects deliver successful MRC Toxicology Unit programme so that they deliver their outcomes to agreed timescales. aims and objectives to the agreed Communication Skills timescales. As this is a three-year training programme it is expected that Communicate widely their research Responsible to: plans, ideas, and projects; write they will make contributions to Gerry Melino scientific papers; and present projects over a three-year lifespan. research results at internal meetings and at conferences. Conduct individual and collaborative Working pattern: Communicate effectively with research projects applying state-of- academic and non-academic Full-time the-art technologies to obtain audiences through written and oral significant advance in the communication, including public understanding of the function of p53 engagement and involvement. family isoforms in cancer biology. Team Work Liaise with colleagues, students, and Objectives visitors to the Unit with a highly collegial, teamwork approach to To conduct research aimed at scientific research. To interact investigating p53-family role in effectively with a wide range of staff, cancer. students, external collaborators, and others to ensure the smooth running To design/conduct experimental work, of the research programme, including data collection, analysis and the effective use of resources e.g. interpretation. To keep accurate datasets, training of others, and records of conducted research and to taking responsibility for use of other contribute to the research of the communal facilities. group as a whole. To plan their own work and objectives on a monthly basis and manage their Development /Training research work within their defined This is a 3 year training position projects along with their manager and designed to enhance their research collaborators. and generic skills through a tailored To develop new skills and undertake development programme. an agreed personal development plan over the three-year period. University of Cambridge www.cam.ac.uk Person specification Essential Desirable Education and Qualifications To have been awarded (or in the final stages of obtaining) a √ PhD in a relevant discipline such as Molecular Biology, Bio- chemistry, Oncology. Specialist Knowledge and Skills √ Evidence of ability to plan and carry out experiments inde- pendently. Previous experience of working with protein and RNA analy- sis, mammalian cell culture, transient and stable transfec- √ tions, immunofluorescence. Good experience of in vivo work using mouse models √ OR strong experience in molecular biology techniques, such as molecular cloning, promoter analysis, gene microarray, ChIP-seq, RNA-seq Relevant Experience Proven skills of working independently to solve experimental √ problems Good publication record in a peer-reviewed journal √ Demonstrable skills in working independently and an ability √ to solve research related problems and challenges Interpersonal and Communication Skills Highly motivated √ Strong desire for self-development √ Vision and ability to plan and manage projects over the me- √ dium term Strong commitment to team work √ Excellent communication skills, both verbal and written. √ Able to supervise junior scientists/students √ Able to collaborate and provide advice to other researchers √ both inside and outside the Unit Additional Requirements Motivation to learn and a willingness to contribute to the wider efforts of the research team and unit √ University of Cambridge www.cam.ac.uk Medical Research Council Toxicology Unit The Unit The Unit is committed to training the next generation of toxicologists and through new and developing Our Mission is to understand the fundamental collaborations, both within Cambridge and UK-wide, mechanisms that determine cell fate following exposure translating our findings into industrial and clinical settings. to exogenous and endogenous toxicants and to translate the Unit’s discovery science into clinical and industrial The Melino group is currently based in central Cambridge environments. (Pathology Building, Tennis Court Road) and will relocate to the refurbished Gleeson building in autumn 2020. We aim to produce novel insights to enhance successful The Toxicology Unit has an active Postgraduate drug design; develop predictive adverse outcome models Postdoctoral Forum (PPF) which supports the ongoing that can be shared with our industrial partners; and gain development of early stage researchers. PPF meetings a greater understanding of diseases that result from toxic take place on a monthly basis and provide an excellent injury and so provide innovative therapeutic avenues for opportunity to practise presentations, share technical experience and to network with other early stage translation into a clinical setting. In addition to informing researchers at the Unit. the field of toxicology, our research outputs will provide novel information about the processes of ageing, including the development of neurological disorders, and will establish new ways in which to stratify patients for therapy. Our research environment provides state-of-the-art research facilities including microscopy, Cryo-EM, flow cytometry, proteomics, bioinformatics and imaging. In addition, excellent opportunities exist for collaborative interactions with University of Cambridge researchers. At the core of each of our programmes is mechanistic toxicology-based research of the highest quality. All programmes are expected to deliver research at an internationally competitive level. University of Cambridge www.cam.ac.uk The School of the Biological Sciences The School of the Biological Sciences is one of the six Schools that are responsible for delivering teaching and research and the administration of those activities within the University. The School delivers internationally-leading research and teaching on animal, plant and microbial science at scales that range from the atomic, molecular and cellular through whole organisms to populations and communities. The research impacts on the pharmaceutical and biotechnological industries, on human and animal health and the clinic as well as in conservation, agriculture and the environment. education in science, technology, The School also contains five major engineering, mathematics and About the School interdisciplinary Institutes: Wellcome medicine (STEMM). The School of the Biological Sciences Trust / CRUK Gurdon Institute for employs around 2000 staff teaching Cancer and Development, Wellcome The University of Cambridge was a over 4000 students (around 2000 Trust / MRC Stem Cell Institute, founder member of Athena SWAN undergraduates in the Natural Cambridge Systems Biology Centre, Charter and the University won its Sciences, Medical Sciences and Cambridge Centre for Crop Science first award in the inaugural round Veterinary Sciences and and the Sainsbury Laboratory for of March 2006. Psychological and Behavioural Plant Development. It has also Sciences Triposes plus around 2000 incorporated the MRC Toxicology Since then, the University has postgraduates). Unit, Leicester which will physically successfully renewed its Bronze relocate to Cambridge in 2020. Athena SWAN award in 2009 and The School collaborates closely with 2012 and in 2014 achieved a Silver the School of Clinical Medicine. The The School is involved with several Athena SWAN award. joint Graduate School of Life Strategic Research Initiatives Sciences looks strategically at including being a major player in the Many of the Departments in the graduate provision and education Cambridge Conservation Initiative . School of Biological Sciences hold across the two Schools and at the The School is associated with the awards at Bronze or Silver level undergraduate level the Medical Museum of Zoology and the Botanic and the School continues to Education Committee oversees Garden. Key officers of the School support the Athena SWAN process medical education. plus details of relevant Research across all subjects. Ethics Committee (Human Biology The School is currently arranged in and Psychology) can be found on the two Faculty Boards (Biology and School's website.. Veterinary Medicine) which are
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