Mitral Valve Regurgitation
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The Ventricles
Guest Editorial Evolution of the Ventricles Solomon Victor, FRCS, FRCP We studied the evolution of ventricles by macroscopic examination of the hearts of Vijaya M. Nayak, MS marine cartilaginous and bony fish, and by angiocardiography and gross examination of Raveen Rajasingh, MPhil the hearts of air-breathing freshwater fish, frogs, turtles, snakes, and crocodiles. A right-sided, thin-walled ventricular lumen is seen in the fish, frog, turtle, and snake. In fish, there is external symmetry of the ventricle, internal asymmetry, and a thick- walled left ventricle with a small inlet chamber. In animals such as frogs, turtles, and snakes, the left ventricle exists as a small-cavitied contractile sponge. The high pressure generated by this spongy left ventricle, the direction of the jet, the ventriculoarterial ori- entation, and the bulbar spiral valve in the frog help to separate the systemic and pul- monary circulations. In the crocodile, the right aorta is connected to the left ventricle, and there is a complete interventricular septum and an improved left ventricular lumen when compared with turtles and snakes. The heart is housed in a rigid pericardial cavity in the shark, possibly to protect it from changing underwater pressure. The pericardial cavity in various species permits move- ments of the heart-which vary depending on the ventriculoarterial orientation and need for the ventricle to generate torque or spin on the ejected blood- that favor run-off into the appropriate arteries and their branches. In the lower species, it is not clear whether the spongy myocardium contributes to myocardial oxygenation. In human beings, spongy myocardium constitutes a rare form of congenital heart disease. -
Blood Flow DHO8 7.8, Pg
Blood Flow DHO8 7.8, pg. 190 HS1/2017-2018 Circuits •Pulmonary circuit –The blood pathway between the right of the heart, to the lungs, and back to the left side of the heart. •Systemic circuit –The pathway between the left side of the heart, to the body, and back to the right side of the heart. The Pathway of Blood •Superior & Inferior Vena •Left Atrium Cava •Mitral Valve •Right Atrium •Left Ventricle •Tricuspid Valve •Aortic Semilunar Valve •Right Ventricle •Aorta •Pulmonary Semilunar -Arteries Valve -Arterioles •Pulmonary Artery -Capillaries •Lungs -Venules –Pulmonary Arterioles -Veins –Pulmonary Capillaries –Pulmonary Venules •Pulmonary Vein Blood Flow Through Heart Do You Know? • When blood leaves the left atrium, where does it go next? a) Aorta b) Left ventricle c) Right atrium d) Pulmonary artery And the answer is….A Do You Know? • After blood leaves the right atrium, what valve prevents the back flow? a) Pulmonary b) Mitral c) Tricuspid d) Aortic And the answer is…C Do You Know? • The right ventricle is the chamber of the heart that pumps blood for the pulmonary circulation. Based on this information, blood from the right ventricle is on its way to the _____. a) Liver b) Lungs c) Hands and feet And the answer is…B Do You Know? • Which of the following is correct order of blood flow for the right side of the heart? a) RA, Tricuspid valve, RV, PSLV, pulmonary artery b) RA, PSLV, RV, Tricuspid valve, pulmonary artery c) RA, Tricuspid valve, RV, pulmonary artery , PSLV And the answer is…A Do You Know? • Which of the following is correct order of blood flow for the left side of the heart? a) LA, Bicuspid valve, LV, ASLV, aorta b) LA, ASLV, LV, Bicuspid valve, aorta c) LA, Bicuspid valve, LV, ASLV, aorta And the answer is…C. -
Mitral Valve Prolapse
MITRAL VALVE PROLAPSE WHAT IS MITRAL VALVE PROLAPSE? The mitral valve is a heart valve with two tissue flaps, called leaflets, that open and close. It is located between the left upper chamber (atrium) and left lower chamber (ventricle) of the heart. Mitral valve prolapse occurs when the mitral valve bulges into the left atrium when the heart contracts (squeezes). This may keep the leaflets from closing properly. The result is a backward flow of blood into the left atrium. This is referred to as leaking or regurgitation. Most of the time, however, mitral valve prolapse causes no symptoms and no problems. WHAT ARE THE SYMPTOMS? Most people with mitral valve prolapse have no symptoms. However, some have brief periods of rapid heartbeat or skipped beats. Some people have sharp chest pains lasting seconds or minutes. Some people have shortness of breath when climbing stairs or with heavy exertion. You may notice symptoms more when you are physically active HOW IS IT DIAGNOSED? Often mitral valve prolapse is discovered during a physical examination, when the doctor listens to your heart with a stethoscope. The valve leaflets create a “click” sound that the doctor may hear. If the valve leaks, the doctor may also hear a murmur. The doctor may ask you to stand, sit, lie down, or squat during your exam, so he or she can better hear the heart sounds. An echocardiogram passes sound waves through the heart to create an image. It is the best test to diagnose mitral valve prolapse. The images show the prolapse, any thickening of the valve leaflets, and any leakage of blood through the prolapsed valve. -
Mitral Valve Prolapse, Arrhythmias, and Sudden Cardiac Death: the Role of Multimodality Imaging to Detect High-Risk Features
diagnostics Review Mitral Valve Prolapse, Arrhythmias, and Sudden Cardiac Death: The Role of Multimodality Imaging to Detect High-Risk Features Anna Giulia Pavon 1,2,*, Pierre Monney 1,2,3 and Juerg Schwitter 1,2,3 1 Cardiac MR Center (CRMC), Lausanne University Hospital (CHUV), 1100 Lausanne, Switzerland; [email protected] (P.M.); [email protected] (J.S.) 2 Cardiovascular Department, Division of Cardiology, Lausanne University Hospital (CHUV), 1100 Lausanne, Switzerland 3 Faculty of Biology and Medicine, University of Lausanne (UniL), 1100 Lausanne, Switzerland * Correspondence: [email protected]; Tel.: +41-775-566-983 Abstract: Mitral valve prolapse (MVP) was first described in the 1960s, and it is usually a benign condition. However, a subtype of patients are known to have a higher incidence of ventricular arrhythmias and sudden cardiac death, the so called “arrhythmic MVP.” In recent years, several studies have been published to identify the most important clinical features to distinguish the benign form from the potentially lethal one in order to personalize patient’s treatment and follow-up. In this review, we specifically focused on red flags for increased arrhythmic risk to whom the cardiologist must be aware of while performing a cardiovascular imaging evaluation in patients with MVP. Keywords: mitral valve prolapse; arrhythmias; cardiovascular magnetic resonance Citation: Pavon, A.G.; Monney, P.; Schwitter, J. Mitral Valve Prolapse, Arrhythmias, and Sudden Cardiac Death: The Role of Multimodality 1. Mitral Valve and Arrhythmias: A Long Story Short Imaging to Detect High-Risk Features. In the recent years, the scientific community has begun to pay increasing attention Diagnostics 2021, 11, 683. -
PERCEVAL SUTURELESS AORTIC HEART VALVE Instructions for Use
HVV_LS-850-0002 Rev X03 PERCEVAL SUTURELESS AORTIC HEART VALVE Instructions for Use CAUTION: Federal Law (USA) restricts the device to sale by or on the order of a physician. SYMBOLS CAUTION: SEE MANUAL FOR INSTRUCTIONS/WARNINGS CONTENTS STERILIZED USING ASEPTIC PROCESSING TECHNIQUE USE BY STORE BETWEEN 5°C AND 25°C SINGLE USE ONLY DO NOT RESTERILIZE CATALOGUE NUMBER SERIAL NUMBER SIZE MANUFACTURER QUANTITY INCLUDED IN PACKAGE DO NOT USE IF PACKAGE IS DAMAGED THIS WAY UP MR CONDITIONAL 1. DESCRIPTION Perceval is a bioprosthetic valve designed to replace a diseased native or a malfunctioning prosthetic aortic valve via open heart surgery, with the unique characteristic of allowing sutureless positioning and anchoring at the implant site. The choice of materials and configuration ensures the device biocompatibility and hemocompatibility. The Perceval prosthesis consists of a tissue component made from bovine pericardium and a self-expandable Nitinol stent, which has the dual role of supporting the valve and fixing it in place. Perceval tissue heart valve is supplied unmounted. Prior to implantation the prosthesis diameter is reduced to a suitable size for loading it on the holder. The valve is then positioned and released in the aortic root, where the stent design and its ability to apply a radial force to the annulus allow stable anchoring of the device. 2. AVAILABLE MODELS The Perceval aortic model is available in four sizes: size S, size M, size L, and size XL. The prosthesis height is 31.0, 33.0, 35.5, and 37.5 mm, respectively. Each size is suitable for a range of aortic annuli and sinotubular junction (STJ) diameters. -
Mitral Valve Prolapse Page 1 of 3
Mitral valve prolapse Page 1 of 3 Mitral valve prolapse Definition Mitral valve prolapse is a heart problem in which the valve that separates the upper and lower chambers of the left side of the heart does not close properly. Alternative Names Barlow syndrome; Floppy mitral valve; Myxomatous mitral valve; Billowing mitral valve; Systolic click-murmur syndrome; Prolapsing mitral leaflet syndrome Causes The mitral valve helps blood on the left side of the heart flow in one direction. It closes to keep blood from moving backwards when the heart beats (contracts). Mitral valve prolapse is the term used when the valve does not close properly. It can be caused by many different things. In most cases, it is harmless and patients usually do not know they have the problem. As much as 10% of the population has some minor, insignificant form of mitral valve prolapse, but it does not generally affect their lifestyle. In a small number of cases, the prolapse can cause blood to leak backwards. This is called mitral regurgitation. Mitral valves that are structurally abnormal can raise the risk for bacterial infection. Some forms of mitral valve prolapse seem to be passed down through families (inherited). Mitral valve prolapse has been associated with Graves disease . Mitral valve prolapse often affects thin women who may have minor chest wall deformities, scoliosis , or other disorders. Mitral valve prolapse is associated with some connective tissue disorders, especially Marfan syndrome . Other conditions include: • Ehlers-Danlos syndrome • Osteogenesis imperfecta • Polycystic kidney disease http://eclinicalworks.adam.com/content.aspx?ref=applications.adam.com&url=eclinicalwo .. -
Cardiovascular System ANS 215 Physiology and Anatomy of Domesticated Animals
Cardiovascular System ANS 215 Physiology and Anatomy of Domesticated Animals I. Structure and Function A. Heart is a cone-shaped, hollow, muscular structure located in the thorax. B. Larger arteries and veins are continuous with the heart as its base. 1. Base is directed upward (dorsal) and forward (cranial). 2. Opposite end of the cone is known as the apex C. Membrane around the heart is known as the pericardium 1. Membrane next to hear fuses with the heart muscle and is called the visceral pericardium or epicardium 2. outer membrane is parietal pericardium 3. apex is free 4. Inflammation of the pericardium is called pericarditis. a. increase in fluid in pericardium b. traumatic pericarditis (hardware) disease in cattle 1 Left view of bovine thorax and abdomen showing location of the heart relative to the stomach. Foreign objects (nails, wire), sometimes ingested by cattle, accumulate in the reticulum ( one of the bovine forestomachs). Contraction of the reticulum can force pointed objects through the reticulum wall and the diaphragm, causing final penetration of the pericardium and subsequent inflammation (pericarditis). 2 D. Myocardium 1. Muscular part of the heart which forms the walls for the chambers 2. Heart chambers (4) divided into left and right side of the heart a. Each side has an atrium and ventricle. b. Each atrium has an extension known as the auricle. c. Atria receive blood from veins and ventricles receive blood from atria. Computer image of a cross sectional view of the heart at the ventricular level showing the chordae tendinae and the relative thickness of the myocardium. -
Growth and Remodeling of Atrioventricular Heart Valves: a Potential Target for Pharmacological Treatment? Manuel K
Available online at www.sciencedirect.com Current Opinion in ScienceDirect Biomedical Engineering Growth and remodeling of atrioventricular heart valves: A potential target for pharmacological treatment? Manuel K. Rausch Abstract backflow or regurgitation of blood. These vital functions Atrioventricular heart valves, that is, the mitral valve and the depend on a well-orchestrated interplay between the tricuspid valve, play vital roles in our cardiovascular system. valves’ components, that is, the valve leaflets, the valve Disease of these valves is, therefore, a significant source of annulus, the chordae tendineae, and the papillary morbidity and mortality. Unfortunately, current treatment op- muscles, refer Figure 1a. In this role, their central tions are suboptimal with significant rates of failure. It was only components, the valve leaflets, are exposed to hemo- recently that we have begun to appreciate that the atrioven- dynamic shear stresses, radial tensile forces at the tricular heart valve leaflets are not just passive flaps, but chordal insertion sites, circumferential tensile forces at actively (mal)adapting tissues. This discovery sheds new light their annular insertion, biaxial stretch due to the on disease mechanisms and provides, thus, possible path- transvalvular pressure, and compressive forces in the ways to new treatments. In this current opinion piece, we coaptation zone. This complex loading regime is cycli- examine the state of our knowledge about the (mal)adaptive cally repeated with every heartbeat for billions of times mechanisms (physiological and pathological growth and throughout our lifetime [1,2]. Ostensibly, these loading remodeling) of the atrioventricular heart valves. Furthermore, modes determine the valves’ microstructure and we review the evidence that suggests that valve maladaptation consequently their mechanical properties [3]. -
Rheumatic Fever and Rheumatic Heart Disease
SEVENTY-FIRST WORLD HEALTH ASSEMBLY A71/25 Provisional agenda item 12.8 12 April 2018 Rheumatic fever and rheumatic heart disease Report by the Director-General 1. In May 2017, the Executive Board, at its 141st session, noted an earlier version of this report1 and adopted resolution EB141.R1 on rheumatic fever and rheumatic heart disease. Paragraphs 15 and 18 in this report contain new text in response to comments from Member States. WHERE DO WE STAND TODAY? 2. Rheumatic heart disease is a preventable yet serious public health problem in low- and middle-income countries and in marginalized communities in high-income countries, including indigenous populations. 3. The disease results from damage to heart valves caused by one or several episodes of rheumatic fever, an autoimmune inflammatory reaction to throat infection caused by group A streptococci (streptococcal pharyngitis). It most commonly occurs in childhood, and can lead to death or life-long disability. Effective early intervention can prevent premature mortality from rheumatic heart disease. 4. Some 30 million people are currently thought to be affected by rheumatic heart disease globally,2 and in 2015 rheumatic heart disease was estimated to have been responsible for 305 000 deaths and 11.5 million disability-adjusted life years lost. Of these deaths 60% occurred prematurely (that is, before the age of 70 years), although these figures are very uncertain owing to incomplete data in many countries. Despite the availability of effective measures for prevention and treatment, there has been little change in the contribution of rheumatic heart disease to overall global mortality between 2000 and 2015.3 5. -
Valvular Heart Disease Acute Rheumatic Fever
Valvular heart disease Acute rheumatic fever Rheumatic fever • It typically occurs several weeks after streptococcal pharyngitis. • The most common pathogen is group A beta-hemolytic streptococci (GABHS) • Streptococcus cross-react with proteins in cardiac valves. • Time from acute streptococcal infection to onset of symptomatic rheumatic fever (RF) is usually 3–4 weeks. • RF is thought to complicate up to 3% of untreated streptococcal sore throats. • Previous episodes of RF predispose to recurrences. Diagnostic criteria for rheumatic fever (Jones criteria) • Evidence of group A streptococcal pharyngitis • Either a positive throat culture or rapid streptococcal antigen test, or an elevated or rising streptococcal antibody titer (samples taken 2 weeks apart). • Plus two major or one major and two minor Jones criteria: Major criteria Minor criteria • Polyarthritis • Fever • Carditis • Arthralgia • Chorea • Prolonged PR interval • Erythema marginatum • Elevated ESR and CRP • Subcutaneous nodules Joints • Migratory large-joint polyarthritis starting in the lower limbs in 75% of cases. Duration is <4 weeks at each site. There is severe pain and tenderness in contrast to a mild degree of joint swelling. Heart • Pancarditis occurs in 50% of cases with features of acute heart failure, mitral and aortic regurgitation, and pericarditis. • Endocarditis • affects the mitral valve (65%–70%), aortic valve (25%), and tricuspid valve (10%, never in isolation), causing acute regurgitation and heart failure but chronic stenosis. • Pericarditis • Pain • Friction rub • rarely causes hemodynamic instability/tamponade or constriction. Heart Myocarditis • Acute heart failure • Arrhythmias • Most common reason of death Skin • Erythema marginatum is an evanescent rash with serpiginous outlines and central clearings on the trunk and proximal limbs. -
Rheumatic Fever and Rheumatic Heart Disease in Children Below the Age of 5 Years in the Tropics
Ann Rheum Dis: first published as 10.1136/ard.24.4.389 on 1 July 1965. Downloaded from Ann. rheumn. Dis. (1965). 24, 389. RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE IN CHILDREN BELOW THE AGE OF 5 YEARS IN THE TROPICS BY ZAHIRA H. ABDIN AND A. EISSA From the Rheumatic and Heart Unit, Children's Hospital, Cairo University, Egypt Rheumatic fever and particularly rheumatic heart months. The history and main clinical finding in disease have always been regarded as rare conditions these four cases is given in the footnote below.* below the age of 5 years and as very rare below 3 years The sex distribution was 42 females to 26 males, (Holt and McIntosh, 1953). Reported cases are i.e. 2-4:1 compared to a general incidence of 1 7:1 few and no account of the clinical pattern of the (Table I). disease in the small child has been found in the TABLE I literature. SEX RATIO AND FAMILIAL TENDENCY In the Rheumatic and Heart Clinic, in Cairo Rto Positive Familial University Hospital, we have had the opportunity Group No. of Sex Ratio History* of examining large numbers of children referred with Cases Female:Male (per cent.) rheumatic fever and rheumatic heart disease in the 1. Children below 5 last 4 years. It was thus possible to collect a fairly years .. 68 2-4:1 20-5 copyright. large group of younger children with the disease and II. Children of all ages 1.7:11,000 3 - 5 we were able to examine the incidence as well as the special features of rheumatic fever and rheumatic * X2 82-5. -
Chapter 12 the Cardiovascular System: the Heart Pages
CHAPTER 12 THE CARDIOVASCULAR SYSTEM: THE HEART PAGES 388 - 411 LOCATION & GENERAL FEATURES OF THE HEART TWO CIRCUIT CIRCULATORY SYSTEM DIVISIONS OF THE HEART FOUR CHAMBERS Right Atrium Left Atrium Receives blood from Receives blood from the systemic circuit the pulmonary circuit FOUR CHAMBERS Right Ventricle Left Ventricle Ejects blood into the Ejects blood into the pulmonary circuit systemic circuit FOUR VALVES –ATRIOVENTRICULAR VALVES Right Atrioventricular Left Atrioventricular Valve (AV) Valve (AV) Tricuspid Valve Bicuspid Valve and Mitral Valve FOUR VALVES –SEMILUNAR VALVES Pulmonary valve Aortic Valve Guards entrance to Guards entrance to the pulmonary trunk the aorta FLOW OF BLOOD MAJOR VEINS AND ARTERIES AROUND THE HEART • Arteries carry blood AWAY from the heart • Veins allow blood to VISIT the heart MAJOR VEINS AND ARTERIES ON THE HEART Coronary Circulation – Supplies blood to the muscle tissue of the heart ARTERIES Elastic artery: Large, resilient vessels. pulmonary trunk and aorta Muscular artery: Medium-sized arteries. They distribute blood to skeletal muscles and internal organs. external carotid artery of the neck Arteriole: Smallest of arteries. Lead into capillaries VEINS Large veins: Largest of the veins. Superior and Inferior Vena Cava Medium-sized veins: Medium sized veins. Pulmonary veins Venules: the smallest type of vein. Lead into capillaries CAPILLARIES Exchange of molecules between blood and interstitial fluid. FLOW OF BLOOD THROUGH HEART TISSUES OF THE HEART THE HEART WALL Pericardium Outermost layer Serous membrane Myocardium Middle layer Thick muscle layer Endocardium Inner lining of pumping chambers Continuous with endothelium CARDIAC MUSCLE Depend on oxygen to obtain energy Abundant in mitochondria In contact with several other cardiac muscles Intercalated disks – interlocking membranes of adjacent cells Desmosomes Gap junctions CONNECTIVE TISSUE Wrap around each cardiac muscle cell and tie together adjacent cells.