Heart Valve Disease: Mitral and Tricuspid Valves
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Differential Diagnosis of Pulmonic Stenosis by Means of Intracardiac Phonocardiography
Differential Diagnosis of Pulmonic Stenosis by Means of Intracardiac Phonocardiography Tadashi KAMBE, M.D., Tadayuki KATO, M.D., Norio HIBI, M.D., Yoichi FUKUI, M.D., Takemi ARAKAWA, M.D., Kinya NISHIMURA,M.D., Hiroshi TATEMATSU,M.D., Arata MIWA, M.D., Hisao TADA, M.D., and Nobuo SAKAMOTO,M.D. SUMMARY The purpose of the present paper is to describe the origin of the systolic murmur in pulmonic stenosis and to discuss the diagnostic pos- sibilities of intracardiac phonocardiography. Right heart catheterization was carried out with the aid of a double- lumen A.E.L. phonocatheter on 48 pulmonic stenosis patients with or without associated heart lesions. The diagnosis was confirmed by heart catheterization and angiocardiography in all cases and in 38 of them, by surgical intervention. Simultaneous phonocardiograms were recorded with intracardiac pressure tracings. In valvular pulmonic stenosis, the maximum ejection systolic murmur was localized in the pulmonary artery above the pulmonic valve and well transmitted to both right and left pulmonary arteries, the superior vena cava, and right and left atria. The maximal intensity of the ejection systolic murmur in infundibular stenosis was found in the outflow tract of right ventricle. The contractility of the infundibulum greatly contributes to the formation of the ejection systolic murmur in the outflow tract of right ventricle. In tetralogy of Fallot, the major systolic murmur is caused by the pulmonic stenosis, whereas the high ventricular septal defect is not responsible for it. In pulmonary branch stenosis, the sys- tolic murmur was recorded distally to the site of stenosis. Intracardiac phonocardiography has proved useful for the dif- ferential diagnosis of various types of pulmonic stenosis. -
The Ventricles
Guest Editorial Evolution of the Ventricles Solomon Victor, FRCS, FRCP We studied the evolution of ventricles by macroscopic examination of the hearts of Vijaya M. Nayak, MS marine cartilaginous and bony fish, and by angiocardiography and gross examination of Raveen Rajasingh, MPhil the hearts of air-breathing freshwater fish, frogs, turtles, snakes, and crocodiles. A right-sided, thin-walled ventricular lumen is seen in the fish, frog, turtle, and snake. In fish, there is external symmetry of the ventricle, internal asymmetry, and a thick- walled left ventricle with a small inlet chamber. In animals such as frogs, turtles, and snakes, the left ventricle exists as a small-cavitied contractile sponge. The high pressure generated by this spongy left ventricle, the direction of the jet, the ventriculoarterial ori- entation, and the bulbar spiral valve in the frog help to separate the systemic and pul- monary circulations. In the crocodile, the right aorta is connected to the left ventricle, and there is a complete interventricular septum and an improved left ventricular lumen when compared with turtles and snakes. The heart is housed in a rigid pericardial cavity in the shark, possibly to protect it from changing underwater pressure. The pericardial cavity in various species permits move- ments of the heart-which vary depending on the ventriculoarterial orientation and need for the ventricle to generate torque or spin on the ejected blood- that favor run-off into the appropriate arteries and their branches. In the lower species, it is not clear whether the spongy myocardium contributes to myocardial oxygenation. In human beings, spongy myocardium constitutes a rare form of congenital heart disease. -
Surgical Management of Transcatheter Heart Valves
Corporate Medical Policy Surgical Management of Transcatheter Heart Valves File Name: surgica l_management_of_transcatheter_heart_valves Origination: 1/2011 Last CAP Review: 6/2021 Next CAP Review: 6/2022 Last Review: 6/2021 Description of Procedure or Service As the proportion of older adults increases in the U.S. population, the incidence of degenerative heart valve disease also increases. Aortic stenosis and mitra l regurgita tion are the most common valvular disorders in adults aged 70 years and older. For patients with severe valve disease, heart valve repair or replacement involving open heart surgery can improve functional status and qua lity of life. A variety of conventional mechanical and bioprosthetic heart valves are readily available. However, some individuals, due to advanced age or co-morbidities, are considered too high risk for open heart surgery. Alternatives to the open heart approach to heart valve replacement are currently being explored. Transcatheter heart valve replacement and repair are relatively new interventional procedures involving the insertion of an artificial heart valve or repair device using a catheter, rather than through open heart surgery, or surgical valve replacement (SAVR). The point of entry is typically either the femoral vein (antegrade) or femora l artery (retrograde), or directly through the myocardium via the apical region of the heart. For pulmonic and aortic valve replacement surgery, an expandable prosthetic heart valve is crimped onto a catheter and then delivered and deployed at the site of the diseased native valve. For valve repair, a small device is delivered by catheter to the mitral valve where the faulty leaflets are clipped together to reduce regurgitation. -
Blood Flow DHO8 7.8, Pg
Blood Flow DHO8 7.8, pg. 190 HS1/2017-2018 Circuits •Pulmonary circuit –The blood pathway between the right of the heart, to the lungs, and back to the left side of the heart. •Systemic circuit –The pathway between the left side of the heart, to the body, and back to the right side of the heart. The Pathway of Blood •Superior & Inferior Vena •Left Atrium Cava •Mitral Valve •Right Atrium •Left Ventricle •Tricuspid Valve •Aortic Semilunar Valve •Right Ventricle •Aorta •Pulmonary Semilunar -Arteries Valve -Arterioles •Pulmonary Artery -Capillaries •Lungs -Venules –Pulmonary Arterioles -Veins –Pulmonary Capillaries –Pulmonary Venules •Pulmonary Vein Blood Flow Through Heart Do You Know? • When blood leaves the left atrium, where does it go next? a) Aorta b) Left ventricle c) Right atrium d) Pulmonary artery And the answer is….A Do You Know? • After blood leaves the right atrium, what valve prevents the back flow? a) Pulmonary b) Mitral c) Tricuspid d) Aortic And the answer is…C Do You Know? • The right ventricle is the chamber of the heart that pumps blood for the pulmonary circulation. Based on this information, blood from the right ventricle is on its way to the _____. a) Liver b) Lungs c) Hands and feet And the answer is…B Do You Know? • Which of the following is correct order of blood flow for the right side of the heart? a) RA, Tricuspid valve, RV, PSLV, pulmonary artery b) RA, PSLV, RV, Tricuspid valve, pulmonary artery c) RA, Tricuspid valve, RV, pulmonary artery , PSLV And the answer is…A Do You Know? • Which of the following is correct order of blood flow for the left side of the heart? a) LA, Bicuspid valve, LV, ASLV, aorta b) LA, ASLV, LV, Bicuspid valve, aorta c) LA, Bicuspid valve, LV, ASLV, aorta And the answer is…C. -
Mitral Valve Prolapse, Arrhythmias, and Sudden Cardiac Death: the Role of Multimodality Imaging to Detect High-Risk Features
diagnostics Review Mitral Valve Prolapse, Arrhythmias, and Sudden Cardiac Death: The Role of Multimodality Imaging to Detect High-Risk Features Anna Giulia Pavon 1,2,*, Pierre Monney 1,2,3 and Juerg Schwitter 1,2,3 1 Cardiac MR Center (CRMC), Lausanne University Hospital (CHUV), 1100 Lausanne, Switzerland; [email protected] (P.M.); [email protected] (J.S.) 2 Cardiovascular Department, Division of Cardiology, Lausanne University Hospital (CHUV), 1100 Lausanne, Switzerland 3 Faculty of Biology and Medicine, University of Lausanne (UniL), 1100 Lausanne, Switzerland * Correspondence: [email protected]; Tel.: +41-775-566-983 Abstract: Mitral valve prolapse (MVP) was first described in the 1960s, and it is usually a benign condition. However, a subtype of patients are known to have a higher incidence of ventricular arrhythmias and sudden cardiac death, the so called “arrhythmic MVP.” In recent years, several studies have been published to identify the most important clinical features to distinguish the benign form from the potentially lethal one in order to personalize patient’s treatment and follow-up. In this review, we specifically focused on red flags for increased arrhythmic risk to whom the cardiologist must be aware of while performing a cardiovascular imaging evaluation in patients with MVP. Keywords: mitral valve prolapse; arrhythmias; cardiovascular magnetic resonance Citation: Pavon, A.G.; Monney, P.; Schwitter, J. Mitral Valve Prolapse, Arrhythmias, and Sudden Cardiac Death: The Role of Multimodality 1. Mitral Valve and Arrhythmias: A Long Story Short Imaging to Detect High-Risk Features. In the recent years, the scientific community has begun to pay increasing attention Diagnostics 2021, 11, 683. -
PERCEVAL SUTURELESS AORTIC HEART VALVE Instructions for Use
HVV_LS-850-0002 Rev X03 PERCEVAL SUTURELESS AORTIC HEART VALVE Instructions for Use CAUTION: Federal Law (USA) restricts the device to sale by or on the order of a physician. SYMBOLS CAUTION: SEE MANUAL FOR INSTRUCTIONS/WARNINGS CONTENTS STERILIZED USING ASEPTIC PROCESSING TECHNIQUE USE BY STORE BETWEEN 5°C AND 25°C SINGLE USE ONLY DO NOT RESTERILIZE CATALOGUE NUMBER SERIAL NUMBER SIZE MANUFACTURER QUANTITY INCLUDED IN PACKAGE DO NOT USE IF PACKAGE IS DAMAGED THIS WAY UP MR CONDITIONAL 1. DESCRIPTION Perceval is a bioprosthetic valve designed to replace a diseased native or a malfunctioning prosthetic aortic valve via open heart surgery, with the unique characteristic of allowing sutureless positioning and anchoring at the implant site. The choice of materials and configuration ensures the device biocompatibility and hemocompatibility. The Perceval prosthesis consists of a tissue component made from bovine pericardium and a self-expandable Nitinol stent, which has the dual role of supporting the valve and fixing it in place. Perceval tissue heart valve is supplied unmounted. Prior to implantation the prosthesis diameter is reduced to a suitable size for loading it on the holder. The valve is then positioned and released in the aortic root, where the stent design and its ability to apply a radial force to the annulus allow stable anchoring of the device. 2. AVAILABLE MODELS The Perceval aortic model is available in four sizes: size S, size M, size L, and size XL. The prosthesis height is 31.0, 33.0, 35.5, and 37.5 mm, respectively. Each size is suitable for a range of aortic annuli and sinotubular junction (STJ) diameters. -
Cardiovascular System ANS 215 Physiology and Anatomy of Domesticated Animals
Cardiovascular System ANS 215 Physiology and Anatomy of Domesticated Animals I. Structure and Function A. Heart is a cone-shaped, hollow, muscular structure located in the thorax. B. Larger arteries and veins are continuous with the heart as its base. 1. Base is directed upward (dorsal) and forward (cranial). 2. Opposite end of the cone is known as the apex C. Membrane around the heart is known as the pericardium 1. Membrane next to hear fuses with the heart muscle and is called the visceral pericardium or epicardium 2. outer membrane is parietal pericardium 3. apex is free 4. Inflammation of the pericardium is called pericarditis. a. increase in fluid in pericardium b. traumatic pericarditis (hardware) disease in cattle 1 Left view of bovine thorax and abdomen showing location of the heart relative to the stomach. Foreign objects (nails, wire), sometimes ingested by cattle, accumulate in the reticulum ( one of the bovine forestomachs). Contraction of the reticulum can force pointed objects through the reticulum wall and the diaphragm, causing final penetration of the pericardium and subsequent inflammation (pericarditis). 2 D. Myocardium 1. Muscular part of the heart which forms the walls for the chambers 2. Heart chambers (4) divided into left and right side of the heart a. Each side has an atrium and ventricle. b. Each atrium has an extension known as the auricle. c. Atria receive blood from veins and ventricles receive blood from atria. Computer image of a cross sectional view of the heart at the ventricular level showing the chordae tendinae and the relative thickness of the myocardium. -
Growth and Remodeling of Atrioventricular Heart Valves: a Potential Target for Pharmacological Treatment? Manuel K
Available online at www.sciencedirect.com Current Opinion in ScienceDirect Biomedical Engineering Growth and remodeling of atrioventricular heart valves: A potential target for pharmacological treatment? Manuel K. Rausch Abstract backflow or regurgitation of blood. These vital functions Atrioventricular heart valves, that is, the mitral valve and the depend on a well-orchestrated interplay between the tricuspid valve, play vital roles in our cardiovascular system. valves’ components, that is, the valve leaflets, the valve Disease of these valves is, therefore, a significant source of annulus, the chordae tendineae, and the papillary morbidity and mortality. Unfortunately, current treatment op- muscles, refer Figure 1a. In this role, their central tions are suboptimal with significant rates of failure. It was only components, the valve leaflets, are exposed to hemo- recently that we have begun to appreciate that the atrioven- dynamic shear stresses, radial tensile forces at the tricular heart valve leaflets are not just passive flaps, but chordal insertion sites, circumferential tensile forces at actively (mal)adapting tissues. This discovery sheds new light their annular insertion, biaxial stretch due to the on disease mechanisms and provides, thus, possible path- transvalvular pressure, and compressive forces in the ways to new treatments. In this current opinion piece, we coaptation zone. This complex loading regime is cycli- examine the state of our knowledge about the (mal)adaptive cally repeated with every heartbeat for billions of times mechanisms (physiological and pathological growth and throughout our lifetime [1,2]. Ostensibly, these loading remodeling) of the atrioventricular heart valves. Furthermore, modes determine the valves’ microstructure and we review the evidence that suggests that valve maladaptation consequently their mechanical properties [3]. -
Anatomy and Physiology of the Tricuspid Valve
JACC: CARDIOVASCULAR IMAGING VOL. 12, NO. 3, 2019 ª 2019 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION PUBLISHED BY ELSEVIER STATE-OF-THE-ART PAPER Anatomy and Physiology of the Tricuspid Valve a,b c c a,b Abdellaziz Dahou, MD, PHD, Dmitry Levin, BA, Mark Reisman, MD, Rebecca T. Hahn, MD SUMMARY An appreciation of the complex and variable anatomy of the tricuspid valve is essential to unraveling the pathophysiology of tricuspid regurgitation. A greater appreciation of normal and abnormal anatomy is important as new methods of treating the tricuspid regurgitation are developed. This review of tricuspid valve and right heart anatomy is followed by a discussion of the possible pathophysiology of secondary (functional) tricuspid regurgitation. (J Am Coll Cardiol Img 2019;12:458–68) © 2019 by the American College of Cardiology Foundation. ith the recognition of the impact of components: the leaflets, the papillary muscles, the W tricuspid regurgitation (TR) on outcomes chordal attachments, and the annulus (with attached in a number of disease states (1–5),inter- atrium and ventricle) (7,12–16).Theleaflets and their est in understanding this disease process has grown. relationship to the chordae and papillary muscle play To help understand the pathophysiology of TR and an important role in TV closure during systole but the role of interventions in treatment of the disease, also may be integrally related to RV size and function. an appreciation of the complex and variable anatomy TRICUSPID VALVE LEAFLETS. Although the TV is – ofthetricuspidvalve(TV)isessential(6 12).Thispa- typically composed of 3 leaflets of unequal size, in per reviews tricuspid and right heart anatomy, dis- many cases, 2 (bicuspid) or more than 3 leaflets may cusses the pathophysiology of secondary TR, be present as anatomic variants in healthy subjects summarizes the anatomic structures relevant to inter- (6,9) (Figure 2). -
Cardiac Amyloidosis and Surgery. What Do We Know About Rare
Cardiac amyloidosis and surgery. What do we know about rare diseases? Carlos Mestres1 and Mathias van Hemelrijck2 1University Hospital Zurich 2UniversitatsSpital Zurich May 3, 2021 Commentary to JOCS-2020-RA-1888 JOCS-2020-RA-1888 Cardiac amyloidosis in non-transplant cardiac surgery Cardiac amyloidosis and surgery. What do we know about rare diseases? Running Title: Cardiac amyloidosis and cardiac surgery Carlos { A. Mestres MD PhD FETCS1, 2, Mathias Van Hemelrijck MD1 1 - Clinic of Cardiac Surgery, University Hospital Zurich,¨ Zurich¨ (Switzerland) 2 - Department of Cardiothoracic Surgery, The University of the Free State, Bloemfontein, (South Africa) Word count (All): 1173 Word count (Text): 774 Key words : Cardiac amyloidosis, cardiac surgery, rare disease Correspondence: Carlos A. Mestres, MD, PhD, FETCS Clinic for Cardiac Surgery University Hospital Zurich,¨ R¨amistrasse 100 CH 8091 Zurich¨ (Switzerland) Email: [email protected] Rare diseases are serious, chronic and potentialy lethal. The European Union (EU) definition of a rare disease is one that affects fewer than 5 in 10,000 people (1). In the EU, these rare diseases are estimated to affect up to 8% of the roughly 500 million population (2). In the United States, a rare disease is defined as a condition affecting fewer than 200,000 people in the US (3). This a definition created by Congress in the Orphan Drug Act of 1983 (4). Therefore, the estimates for the US are that 25-30 million people are affected by a rare disease. There are more than 6000 rare diseases and 80% are genetic disorders diagnosed during childhood. Despite all community efforts, there are still a lack of an universal definition of rare diseases. -
Chapter 12 the Cardiovascular System: the Heart Pages
CHAPTER 12 THE CARDIOVASCULAR SYSTEM: THE HEART PAGES 388 - 411 LOCATION & GENERAL FEATURES OF THE HEART TWO CIRCUIT CIRCULATORY SYSTEM DIVISIONS OF THE HEART FOUR CHAMBERS Right Atrium Left Atrium Receives blood from Receives blood from the systemic circuit the pulmonary circuit FOUR CHAMBERS Right Ventricle Left Ventricle Ejects blood into the Ejects blood into the pulmonary circuit systemic circuit FOUR VALVES –ATRIOVENTRICULAR VALVES Right Atrioventricular Left Atrioventricular Valve (AV) Valve (AV) Tricuspid Valve Bicuspid Valve and Mitral Valve FOUR VALVES –SEMILUNAR VALVES Pulmonary valve Aortic Valve Guards entrance to Guards entrance to the pulmonary trunk the aorta FLOW OF BLOOD MAJOR VEINS AND ARTERIES AROUND THE HEART • Arteries carry blood AWAY from the heart • Veins allow blood to VISIT the heart MAJOR VEINS AND ARTERIES ON THE HEART Coronary Circulation – Supplies blood to the muscle tissue of the heart ARTERIES Elastic artery: Large, resilient vessels. pulmonary trunk and aorta Muscular artery: Medium-sized arteries. They distribute blood to skeletal muscles and internal organs. external carotid artery of the neck Arteriole: Smallest of arteries. Lead into capillaries VEINS Large veins: Largest of the veins. Superior and Inferior Vena Cava Medium-sized veins: Medium sized veins. Pulmonary veins Venules: the smallest type of vein. Lead into capillaries CAPILLARIES Exchange of molecules between blood and interstitial fluid. FLOW OF BLOOD THROUGH HEART TISSUES OF THE HEART THE HEART WALL Pericardium Outermost layer Serous membrane Myocardium Middle layer Thick muscle layer Endocardium Inner lining of pumping chambers Continuous with endothelium CARDIAC MUSCLE Depend on oxygen to obtain energy Abundant in mitochondria In contact with several other cardiac muscles Intercalated disks – interlocking membranes of adjacent cells Desmosomes Gap junctions CONNECTIVE TISSUE Wrap around each cardiac muscle cell and tie together adjacent cells. -
Positive Maternal and Foetal Outcomes After Cardiopulmonary Bypass Surgery
Case Study: Positive maternal and foetal outcomes after cardiopulmonary bypass surgery Positive maternal and foetal outcomes after cardiopulmonary bypass surgery in a parturient with severe mitral valve disease aMokgwathi GT, MBChB aLebakeng EM, MBChB, DA(SA), MMed(Anaes) bOgunbanjo GA, MBBS, FCFP(SA), MFamMed, FACRRM, FACTM, FAFP(SA), FWACP(Fam Med) aDepartment of Anaesthesiology, University of Limpopo (Medunsa Campus) bDepartment of Family Medicine and Primary Health Care, University of Limpopo (Medunsa Campus) Correspondence to: Dr GT Mokgwathi, e-mail: [email protected] Keywords: anaesthesia, cardiac surgery, parturient, cardiopulmonary bypass surgery, mitral valve replacement Abstract This case study describes the successful management of a parturient with severe mitral stenosis and moderate mitral regurgitation who underwent cardiopulmonary bypass (CPB) surgery. A healthy baby was delivered by Caesarean section 11 days later. The effects of CPB surgery and mitral valve replacement on parturient and foetus are discussed. Peer reviewed. (Submitted: 2011-01-04, Accepted: 2011-06-16) © SASA South Afr J Anaesth Analg 2011;17(4):299-302 Introduction she was classified as New York Heart Association (NYHA) class III and World Health Organization (WHO) heart Heart disease is the primary cause of nonobstetric mortality failure stage C. Her blood pressure was 90/60 mmHg in pregnancy, occurring in 1-4 % of pregnancies1-3 and and her heart rate was 82 beats per minute and regular. accounting for 10–15 % of maternal mortality in developed She had a tapping apex beat, loud first heart sound, loud countries.1,2 Cardiac disease contributes to 40.2% of pulmonary component of the second heart sound and a maternal deaths in South Africa.4 Soma-Pillay et al noted grade 3/4 diastolic murmur heard loudest at the apex.