CHMP1B Polyclonal Antibody (A01)

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CHMP1B polyclonal antibody (A01) Catalog # : H00057132-A01 規格 : [ 50 uL ] List All Specification Application Image Product Mouse polyclonal antibody raised against a partial recombinant Western Blot (Recombinant protein) Description: CHMP1B. ELISA Immunogen: CHMP1B (NP_065145, 145 a.a. ~ 199 a.a) partial recombinant protein with GST tag. Sequence: PQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQR LARLRDQV Host: Mouse Reactivity: Human Quality Control Antibody Reactive Against Recombinant Protein. Testing: Western Blot detection against Immunogen (32.16 KDa) . Storage Buffer: 50 % glycerol Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. Instruction: MSDS: Download Datasheet: Download Publication Reference 1. MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. Lee S, Chang J, Renvoise B, Tipirneni A, Yang S, Blackstone C.Mol Biol Cell. 2012 Nov;23(22):4347-61. doi: 10.1091/mbc.E12-04-0292. Epub 2012 Sep 26. 2. Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Yang D, Rismanchi N, Renvoise B, Lippincott-Schwartz J, Blackstone C, Hurley JH.Nat Struct Mol Biol. 2008 Dec;15(12):1278-86. Epub 2008 Nov 9. Applications Western Blot (Recombinant protein) Protocol Download ELISA Page 1 of 2 2016/5/24 Gene Information Entrez GeneID: 57132 GeneBank NM_020412 Accession#: Protein NP_065145 Accession#: Gene Name: CHMP1B Gene Alias: C10orf2,C18-ORF2,C18orf2,CHMP1.5,Vps46-2 Gene chromatin modifying protein 1B Description: Omim ID: 606486 Gene Ontology: Hyperlink Gene Summary: CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM Other vacuolar protein sorting 46-2 Designations: Gene Pathway Endocytosis Related Disease Bipolar Disorder Genetic Predisposition to Disease Schizophrenia 服務條款 | 隱私權政策 | 著作及商標 | 網站地圖 ©2016 亞諾法生技股份有限公司 Abnova Corporation. 版權所有. Page 2 of 2 2016/5/24.

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Role of RUNX1 in Aberrant Retinal Angiogenesis Jonathan D
Page 1 of 25 Diabetes Identification of RUNX1 as a mediator of aberrant retinal angiogenesis Short Title: Role of RUNX1 in aberrant retinal angiogenesis Jonathan D. Lam,†1 Daniel J. Oh,†1 Lindsay L. Wong,1 Dhanesh Amarnani,1 Cindy Park- Windhol,1 Angie V. Sanchez,1 Jonathan Cardona-Velez,1,2 Declan McGuone,3 Anat O. Stemmer- Rachamimov,3 Dean Eliott,4 Diane R. Bielenberg,5 Tave van Zyl,4 Lishuang Shen,1 Xiaowu Gai,6 Patricia A. D’Amore*,1,7 Leo A. Kim*,1,4 Joseph F. Arboleda-Velasquez*1 Author affiliations: 1Schepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford St., Boston, MA 02114 2Universidad Pontificia Bolivariana, Medellin, Colombia, #68- a, Cq. 1 #68305, Medellín, Antioquia, Colombia 3C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114 4Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles St., Boston, MA 02114 5Vascular Biology Program, Boston Children’s Hospital, Department of Surgery, Harvard Medical School, 300 Longwood Ave., Boston, MA 02115 6Center for Personalized Medicine, Children’s Hospital Los Angeles, Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA 7Department of Pathology, Harvard Medical School, 25 Shattuck St., Boston, MA 02115 Corresponding authors: Joseph F. Arboleda-Velasquez: [email protected] Ph: (617) 912-2517 Leo Kim: [email protected] Ph: (617) 912-2562 Patricia D’Amore: [email protected] Ph: (617) 912-2559 Fax: (617) 912-0128 20 Staniford St. Boston MA, 02114 † These authors contributed equally to this manuscript Word Count: 1905 Tables and Figures: 4 Diabetes Publish Ahead of Print, published online April 11, 2017 Diabetes Page 2 of 25 Abstract Proliferative diabetic retinopathy (PDR) is a common cause of blindness in the developed world’s working adult population, and affects those with type 1 and type 2 diabetes mellitus.
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