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2016 Joint Meeting Program
April 15 – 17, 2016 Fairmont Chicago Millennium Park • Chicago, Illinois The AAP/ASCI/APSA conference is jointly provided by Boston University School of Medicine and AAP/ASCI/APSA. Meeting Program and Abstracts www.jointmeeting.org www.jointmeeting.org Special Events at the 2016 AAP/ASCI/APSA Joint Meeting Friday, April 15 Saturday, April 16 ASCI President’s Reception ASCI Food and Science Evening 6:15 – 7:15 p.m. 6:30 – 9:00 p.m. Gold Room The Mid-America Club, Aon Center ASCI Dinner & New Member AAP Member Banquet Induction Ceremony (Ticketed guests only) (Ticketed guests only) 7:00 – 10:00 p.m. 7:30 – 9:45 p.m. Imperial Ballroom, Level B2 Rouge, Lobby Level How to Solve a Scientific Puzzle: Speaker: Clara D. Bloomfield, MD Clues from Stockholm and Broadway The Ohio State University Comprehensive Cancer Center Speaker: Joe Goldstein, MD APSA Welcome Reception & University of Texas Southwestern Medical Center at Dallas Presidential Address APSA Dinner (Ticketed guests only) 9:00 p.m. – Midnight Signature Room, 360 Chicago, 7:30 – 9:00 p.m. John Hancock Center (off-site) Rouge, Lobby Level Speaker: Daniel DelloStritto, APSA President Finding One’s Scientific Niche: Musings from a Clinical Neuroscientist Speaker: Helen Mayberg, MD, Emory University Dessert Reception (open to all attendees) 10:00 p.m. – Midnight Imperial Foyer, Level B2 Sunday, April 17 APSA Future of Medicine and www.jointmeeting.org Residency Luncheon Noon – 2:00 p.m. Rouge, Lobby Level 2 www.jointmeeting.org Program Contents General Program Information 4 Continuing Medical Education Information 5 Faculty and Speaker Disclosures 7 Scientific Program Schedule 9 Speaker Biographies 16 Call for Nominations: 2017 Harrington Prize for Innovation in Medicine 26 AAP/ASCI/APSA Joint Meeting Faculty 27 Award Recipients 29 Call for Nominations: 2017 Harrington Scholar-Innovator Award 31 Call for Nominations: George M. -
Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The
SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland. -
![CRISPR-Cas Arxiv:1712.09865V2 [Q-Bio.PE] 26 Mar 2018](https://docslib.b-cdn.net/cover/9302/crispr-cas-arxiv-1712-09865v2-q-bio-pe-26-mar-2018-1289302.webp)
CRISPR-Cas Arxiv:1712.09865V2 [Q-Bio.PE] 26 Mar 2018
The physicist's guide to one of biotechnology's hottest new topics: CRISPR-Cas Melia E. Bonomo1;3 and Michael W. Deem1;2;3 1Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA 2Department of Bioengineering, Rice University, Houston, TX 77005, USA 3Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA Contents 1 Introduction 3 2 Three stages of immunity 4 2.1 Adaptation . 6 2.2 Expression . 7 2.3 Interference . 8 3 Molecular memory cassettes 9 3.1 Timing and origin of acquired spacers . 10 3.2 Experimental studies of spacer diversity . 11 3.3 Modeling spacer diversity in the CRISPR locus . 12 3.4 Effects of spacer acquisition and deletion rates . 14 3.5 Timescale of spacer expression . 17 4 Horizontal gene transfer 17 4.1 Acquisition of CRISPR loci and spacers . 18 arXiv:1712.09865v2 [q-bio.PE] 26 Mar 2018 4.2 CRISPR-Cas restriction of HGT . 19 4.3 Persistent HGT . 20 5 Specificity 21 5.1 Cas specificity and conformational changes . 21 5.2 Identifying CRISPR-Cas PAMs . 24 5.3 Self and non-self discrimination . 25 5.4 Cross-reactivity . 26 5.5 Profiling Cas9 off-target activity . 27 1 6 Evolution and abundance of CRISPR loci 29 6.1 Support for a Lamarckian-type evolution . 29 6.2 Strain divergence . 31 6.3 Selection pressure for survival of the cell . 33 6.4 Impact of effectiveness . 34 7 Cost and regulation of CRISPR Activity 35 7.1 Spacer maintenance considerations . 36 7.2 Turning CRISPR on and off . -
Annual Report 20 15
ANNUAL REPORT 2015 HUMAN FRONTIER SCIENCE PROGRAM The Human Frontier Science Program is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontier of the life sciences. Special emphasis is given to the support and training of independent young investigators, beginning at the postdoctoral level. The Program is implemented by an international organization, supported financially by Australia, Canada, France, Germany, India, Italy, Japan, the Republic of Korea, New Zealand, Norway, Singapore, Switzerland, the United Kingdom, the United States of America, and the European Union. Since 1990, over 7000 awards have been made to researchers from more than 70 countries. Of these, 26 HFSP awardees have gone on to receive the Nobel Prize. APRIL 2015 - MARCH 2016 ANNUAL REPORT — 3 — The following documents are available on the HFSP website www.hfsp.org: Joint Communiqués (Tokyo 1992, Washington 1997, Berlin 2002, Bern 2004, Ottawa 2007, Canberra 2010, Brussels 2013, London 2016): http://www.hfsp.org/about-us/governance/intergovernmental-conference Statutes of the International Human Frontier Science Program Organization : http://www.hfsp.org/about-us/governance/statutes Guidelines for the participation of new members in HFSPO : http://www.hfsp.org/about-us/new-membership General reviews of the HFSP (1996, 2001, 2006-2007, 2010): http://www.hfsp.org/about-us/reviews-hfsp Updated and previous lists of awards, including titles and abstracts: http://www.hfsp.org/awardees — 4 — Table of contents INTRODUCTION -
Nominations for Breakthrough Prizes in Life Sciences Now Open Online
Nominations for Breakthrough Prizes in life sciences now open online 04 September 2013 | News | By BioSpectrum Bureau Nominations for Breakthrough Prizes in life sciences now open online The Breakthrough Prize in Life Sciences Foundation recently announced the opening of online nominations for Breakthrough Prizes for 2014. The rules and nomination form are made available in their official site. As per the rules, anyone can nominate a candidate online and all submissions must be completed by a third party. Nominations will be accepted through October 2, 2013. This year the foundation will award up to five prizes worth $3 million each, sponsored by Sergey Brin and Anne Wojcicki, Mark Zuckerberg and Priscilla Chan, and Yuri Milner. All prizes will be awarded for research aimed at curing deadly diseases and extending human life, with special attention to recent discoveries. One prize sponsored by Sergey Brin and Anne Wojcicki is aimed specifically at advancements in Parkinson's disease research. The 2014 prize winners will be chosen by the foundation's selection committee, comprised of prior recipients of the Breakthrough Prize in life sciences, including, Cornelia I. Bargmann, David Botstein, Lewis C. Cantley, Hans Clevers, Napoleone Ferrara, Titia de Lange, Eric S. Lander, Charles L. Sawyers, Bert Vogelstein, Robert A. Weinberg, and Shinya Yamanaka. "We all benefit from the brilliance and commitment of researchers at the frontiers of medical science. This is a chance to reward their achievements and support their future work. If you think someone deserves a Breakthrough Prize, you have the power to put them in the running," said Mr Art Levinson, Chairman of Apple Inc., Genentech, and The Breakthrough Prize in Life Sciences foundation. -
(Hans) Carolus Clevers (1957) E-Mail [email protected]
CURRICULUM VITAE Name Johannes (Hans) Carolus Clevers (1957) E-mail [email protected] Education 1975 - 1982 M.Sc. ("Doctoraal") in Biology. University of Utrecht 1978 - 1984 M.D. ("Artsexamen") University of Utrecht 1984 - 1985 Ph.D. ("Promotie") University of Utrecht Scientific training/positions 1985 - 1989 Postdoctoral Fellow, Cox Terhorst Lab at the Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA 1989 - 1991 Assistant Professor, Department of Clinical Immunology, University of Utrecht 1991 - 2002 Professor and Chairman, Dept. of Immunology, Faculty of Medicine, University of Utrecht 2002 - 2012 Director of the Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences 2002 - 2020 Professor in Molecular Genetics at University Medical Center Utrecht 2002 - present Principal Investigator of a research group of ~40 scientists at Hubrecht Institute, Utrecht 2012 - 2015 President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam 2014 - 2020 Chief Scientific Officer of HUB Organoids Technology, Utrecht 2015 - 2019 Chief Scientific Officer/Director Research of the Princess Máxima Center, Utrecht 2015 - present Principal Investigator at the Princess Máxima Center, Utrecht 2017 - present Oncode Investigator 2020 - present University Professor at University Utrecht Prizes, awards 2000 Catharijne-prize for medical research, Utrecht 2001 Award from the European Society for Clinical Investigation, Nice 2001 Spinoza Award of the Netherlands Reserach Council (NOW, Den Haag) 2004 Louis-Jeantet Prize for -
The Shaw Prize
The Shaw Prize The Shaw Prize is an international award to honour individuals who are currently active in their respective fields and who have recently achieved distinguished and significant advances, who have made outstanding contributions in academic and scientific research or applications, or who in other domains have achieved excellence. The award is dedicated to furthering societal progress, enhancing quality of life, and enriching humanity’s spiritual civilization. Preference is to be given to individuals whose significant works were recently achieved and who are currently active in their respective fields. ~ 1 ~ Founder of The Shaw Prize Mr Shaw, born in China in 1907, was a native of Ningbo County, Zhejiang Province. He joined his brother’s film company in China in the 1920s. During the 1950s he founded the film company Shaw Brothers (HK) Limited in Hong Kong. He was one of the founding members of Television Broadcasts Limited (TVB) launched in Hong Kong in 1967. As an established figure in the film and media industry, Mr Shaw gained insight into the needs of the people, and as a visionary he saw how, in addition to the fleeting escapism of entertainment, the more substantial benefits of education and healthcare would greatly impact lives for the better. He established two charities: The Shaw Foundation Hong Kong and The Sir Run Run Shaw Charitable Trust, both dedicated to the promotion of education, scientific and technological research, medical and welfare services, and culture and the arts. The Shaw Foundation quickly gained momentum in a wide range of philanthropic work: supporting educational institutions as well as hospitals and clinics in Hong Kong, the rest of China and beyond. -
Report for the Academic Year 2007-2008
Institute for Advanced Study IASInstitute for Advanced Study Report for 2007–2008 INSTITUTE FOR ADVANCED STUDY EINSTEIN DRIVE PRINCETON, NEW JERSEY 08540 609-734-8000 www.ias.edu Report for the Academic Year 2007–2008 t is fundamental in our purpose, and our express I. desire, that in the appointments to the staff and faculty, as well as in the admission of workers and students, no account shall be taken, directly or indirectly, of race, religion, or sex. We feel strongly that the spirit characteristic of America at its noblest, above all the pursuit of higher learning, cannot admit of any conditions as to personnel other than those designed to promote the objects for which this institution is established, and particularly with no regard whatever to accidents of race, creed, or sex. Extract from the letter addressed by the Institute’s Founders, Louis Bamberger and Caroline Bamberger Fuld, to the first Board of Trustees, dated June 4, 1930. Newark, New Jersey Cover Photo: Dinah Kazakoff The Institute for Advanced Study exists to encourage and support fundamental research in the sciences and humanities—the original, often speculative, thinking that produces advances in knowledge that change the way we understand the world. THE SCHOOL OF HISTORICAL STUDIES, established in 1949 with the merging of the School of Economics and Politics and the School of Humanistic Studies, is concerned principally with the history of Western European, Near Eastern, and East Asian civilizations. The School actively promotes interdisciplinary research and cross-fertilization of ideas. THE SCHOOL OF MATHEMATICS, established in 1933, was the first School at the Institute for Advanced Study. -
EMBO Facts & Figures 2011
excellence in life sciences excellence in life sciences young investigators|courses,workshops,conference series & symposia|installation grantees|long-term fellows|short-term fellows|policy, science & society|the EMBO Journal|EMBO reports|molecular systems biology|EMBO molecular medicine|global exchange|gold medal|the EMBO meeting|women in science| EMBO reports|molecular systems biology|EMBO molecular medicine|global exchange|gold medal|the EMBO meeting|women in science|young investigators|courses,workshops,conference series & symposia|installation grantees|long-term fellows|short-term fellows|policy, science & society|the EMBO Journal| global exchange|gold medal|the EMBO meeting|women in science|young investigators|long-term fellows|short-term fellows|policy, science & society|the EMBO Journal|courses,workshops,conference series & symposia|EMBO reports|molecular systems biology|EMBO molecular medicine|installation grantees| EMBO molecular medicine|installation grantees|long-term fellows|gold medal|molecular systems biology|short-term fellows|the EMBO meeting|women in science|youngReykjavik investigators|courses,workshops,conference series & symposia|global exchange|EMBO reports|policy, science & society|the EMBO Journal| gold medal|the EMBO meeting|women in science|young investigators|courses,workshops,conference series & symposia|global exchange|policy, science & society|the EMBO Journal|EMBO reports|molecular systems biology|EMBO molecular medicine|installation grantees|long-term fellows|short-term fellows| courses,workshops,conference -
Combio 2011 Plenary Lectures
ComBio 2011 Plenary Lectures WELCOME PROGRAMME REGISTER ABSTRACTS SOCIAL HOTELS EXHIBITION INFORMATION CONTACT Plenary Lectures Confirmed plenary speakers as this time are: Nenad Ban Swiss Federal Institute of Technology (ETH), Zurich, Swizerland Michael Breitenbach Department of Cell Biology, University of Salzburg, Austria Hans Clevers Hubrecht Institute, Utrecht, The Netherlands Dave Drubin University of California, Berkeley, USA Margaret Fuller Stanford University, USA Julian Hibberd University of Cambridge, UK Stephen Kowalczykowski University of California, Davis, USA Hartmut Luecke University of California, Irvine, USA Hiroshi Ohno Riken, Japan Michael Parker St Vincent’s Institute, Melbourne, Australia Lemberg Medal Lecture Stuart Pitson Institute of Medical & Veterinary Science, Adelaide, Australia Merck Research Excellence Medal Lecture Howard Riezman University of Geneva, Switzerland Andrej Šali University of California, San Francisco, USA Matt Scott Stanford University, Palo Alto, USA Lawren Sack University of California, Los Angeles, USA Natalie Strynadka University of British Columbia, Vancouver, Canada David Teplow University of California, Los Angeles, USA Roger Tsien University of California, San Diego, USA Nobel Prize http://www.asbmb.org.au/combio2011/plenary.html[10/23/2011 3:02:19 PM] ComBio 2011 Plenary Lectures Chemistry 2008 Carroll P. Vance United States Department of Agriculture, USA Susanne von Caemerer Australian National University, Canberra, Australia J.G. Wood Lecture ASBMB MEDALLIST SPEAKERS ASBMB Lemberg Medallist: Michael Parker Professor Michael Parker is Deputy Director of St Vincent’s Institute of Medical Research in Melbourne where he is Head of the Biota Structural Biology Laboratory and the ACRF Rational Drug Discovery Facility. He is an Australian Research Council Federation Fellow and a Professorial Fellow at the Bio21 Institute, University of Melbourne. -
Funding Breakthroughs
TRANSLATIONAL NOTES probability of doing significant science in the next-funded period, based on both their track record and their proposal,” said Moses. “We depend on help from outside scientists and clinicians for advice.” Jack Dixon, VP and CSO of the Howard Hughes Medical Institute, noted that young blood was absent from the first round of the $3 million prizes. Funding “The Breakthrough Prize in Life Sciences Foundation has selected an impressive group of people—terrific scientists—to give their awards to, but looking at the list, none of these individuals are beginners,” he said. breakthroughs “Shinya Yamanaka has already won a Nobel Prize, and three of their By Tracey Baas, Senior Editor awardees—Cornelia Bargmann, Charles Sawyers and Bert Vogelstein— are Howard Hughes Medical Institute investigators.” The $33 million in prize money from the Breakthrough Prize in Life HHMI supports about 330 independent researchers as investigators Sciences Foundation went to 11 deserving scientists. But it is worth at institutions throughout the U.S. By appointing scientists as HHMI debating whether, in an age of austerity, there are more efficient ways for investigators, rather than awarding them traditional grants for specific the billionaire backers to put their money to work. research projects, the researchers receive flexible funding for five years. One line of thought holds that giving money to young researchers About 80% of the HHMI investigators are reappointed following a might be a better use of new funds than giving prize money to established review process. HHMI also provides 6 years of funding to an additional researchers who already are well funded. -
Mr Wai-Man Chan, Raymond
The Shaw Prize The Shaw Prize is an international award to honour individuals who are currently active in their respective fields and who have recently achieved distinguished and significant advances, who have made outstanding contributions in academic and scientific research or applications, or who in other domains have achieved excellence. The award is dedicated to furthering societal progress, enhancing quality of life, and enriching humanity’s spiritual civilization. Preference is to be given to individuals whose significant works were recently achieved and who are currently active in their respective fields. ~ 1 ~ Founder of The Shaw Prize Mr Shaw, born in China in 1907, was a native of Ningbo County, Zhejiang Province. He joined his brother’s film company in China in the 1920s. During the 1950s he founded the film company Shaw Brothers (HK) Limited in Hong Kong. He was one of the founding members of Television Broadcasts Limited (TVB) launched in Hong Kong in 1967. As an established figure in the film and media industry, Mr Shaw gained insight into the needs of the people, and as a visionary he saw how, in addition to the fleeting escapism of entertainment, the more substantial benefits of education and healthcare would greatly impact lives for the better. He established two charities: The Shaw Foundation Hong Kong and The Sir Run Run Shaw Charitable Trust, both dedicated to the promotion of education, scientific and technological research, medical and welfare services, and culture and the arts. The Shaw Foundation quickly gained momentum in a wide range of philanthropic work: supporting educational institutions as well as hospitals and clinics in Hong Kong, the rest of China and beyond.