Combio 2011 Plenary Lectures
Total Page:16
File Type:pdf, Size:1020Kb

Load more
Recommended publications
-
Regulation of Recombination and Genomic Maintenance
Downloaded from http://cshperspectives.cshlp.org/ on September 27, 2021 - Published by Cold Spring Harbor Laboratory Press Regulation of Recombination and Genomic Maintenance Wolf-Dietrich Heyer1,2 1Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, California 95616-8665 2Department of Molecular and Cellular Biology, University of California, Davis, Davis, California 95616-8665 Correspondence: [email protected] Recombination is a central process to stably maintain and transmit a genome through somatic cell divisions and to new generations. Hence, recombination needs to be coordi- nated with other events occurring on the DNA template, such as DNA replication, transcrip- tion, and the specialized chromosomal functions at centromeres and telomeres. Moreover, regulation with respect to the cell-cycle stage is required as much as spatiotemporal coor- dination within the nuclear volume. These regulatory mechanisms impinge on the DNA substrate through modifications of the chromatin and directly on recombination proteins through a myriad of posttranslational modifications (PTMs) and additional mechanisms. Although recombination is primarily appreciated to maintain genomic stability, the process also contributes to gross chromosomal arrangements and copy-number changes. Hence, the recombination process itself requires quality control to ensure high fidelity and avoid genomic instability. Evidently, recombination and its regulatory processes have significant impact on human disease, specifically cancer and, possibly, -
The University News, Vol. 5, No. 8, May 31, 1979
VOL5N08 MAY 311979 Newsletter for I( The University of Newcastle New Oval Mater ial isi ng Enrolments Enrolment oJ students as at . April 30 totalled 4364 compared with 4429 in 1978. This rep resents an annual rate of decrease of 1% compared with 4% for 1977-78. The enrolment for higher degrees increased this year from 391 to 403 - a gain of 3%. There has been a 2% fall in the enrolment in other than higher degrees, now 3961 as against 4038 in 1978. Of the total enrolment 55% is full-time and 45% part-time. This compares wit~ 58% and 42% respectively in 1978. In terms of students the full-time enrol ment is 2392 and the part-time 1937. The male student numbers are 2735 or 63% of the total, and the female enrolment 1629. A combination of favourable When construction commenced earl or 37%. In 1978. 64% was male growing conditions and fertiliz ier this year sufficient finance and 36% female. ation has allowed rapid progress was available to complete only half of the project. Now it has The number of students from to be made with work on NO.3 overseas has continued to fall Oval. The Electricity Commission been decided to complete the from 188 in 1977, 160 in 1978 of New South Wales and the entire oval in the very near to 145 in 1979. University are jointly construct future. tng the playing area, which The University will have the use The greater number of our over covers almost the same area as of the oval for an initial period seas students came from: NO.1 Oval. -
The Canadian Society of Biochemistry and Molecular & Cellular Biology
Bulletin The Canadian Society of Biochemistry and Molecular & Cellular Biology/ La Société canadienne de biochimie et de biologie moléculaire et cellulaire 2001 www.csbmcb.ca ISSN 1197-6578/2001 COVER PHOTO: A schematic diagram of the Sec dependent protein translocation system [from The 2001 Merck Frosst Prize Award Address Mark Paetzel and Natalie C. J. Strynadka] Contents CSBMCB Board for 2001-2002 ....................................................................................... 4 CSBMCB President’s Report ............................................................................................ 5 Incoming Members of CSBMCB Executive Board 2001-2002 ......................................... 6 IUBMB Toronto Congress Update ................................................................................. 13 Minutes of the 44th CSBMCB Annual General Meeting ................................................ 14 11th Winternational Symposium .................................................................................. 21 44th Annual Meeting of the CSBMCB .......................................................................... 22 Society Awards 2000-2001 ........................................................................................... 27 Workshop On: Myelin Structure And Its Role In Autoimmunity ..................................... 31 Report on the AUUBC................................................................................................... 34 In Memoriam Peter Dolphin .......................................................................................................... -
Low Resolution
Australian Biochemist The Magazine of the Australian Society for Biochemistry and Molecular Biology Inc. August 2019, Volume 50, Number 2 VOLISSN 50 NO 2 AUGUST 1443-0193 2019 AUSTRALIAN BIOCHEMIST PAGE 1 Be inspired during the 3- da y progra m including a fa nta stic lineup of industry lea ding interna tiona l plena ry spea kers, a nd hea r from our society specia lty lectures, be enga ged with poster presenta tions a nd lea rn a t the E/MCR mini- symposium. For more informa tion on our spea kers, progra m a nd to register, visit our website www.a sbmb2019.com.a u REGISTER NOW! PAGE 2 AUSTRALIAN BIOCHEMIST VOL 50 NO 2 AUGUST 2019 Table of Contents 4 Editorial Committee 5 Editorial 7 Publications with Impact Distinct Mechanisms Govern Recognition of Viral and Host Ligands by an Innate Immune Receptor Buying Time for Contractile Signaling Genetic Stutters, Gut Feelings and Neurodegenerative Disease 11 Off the Beaten Track Why it Sometimes Pays to Work for Money 14 ASBMB Education Feature Glycogen Builder: the Game Making a Drama Out of Biochemistry From the Whiteboard to the Conference: Scaffolding Conference-style Poster Presentations 18 SDS Page The Importance of Blue Sky Research 19 Competition: Unscramble 20 ASBMB 2019 International Plenary Speaker Profiles 22 ASBMB 2019 Symposium Speakers 23 Melbourne Protein Group: an ASBMB Special Interest Group 24 ASBMB Shimadzu Education Award Report 26 Intellectual Property Patenting Inventions in the Microbiome Space 29 Queen’s Birthday Honours for ASBMB Members 31 ASBMB Awards 2020 33 Election of Council 2020 33 Annual General Meeting of ASBMB 34 New ASBMB Members 35 Forthcoming Meetings 36 Our Sustaining Members 41 ASBMB Council 42 Directory Front Cover Bachelor of Biomedicine students from the University of Melbourne participating in an acting skills workshop with Rinske Ginsberg, VCA Theatre, as part of the Performing Sciences program, where students devise short performances embodying biochemical concepts. -
2016 Joint Meeting Program
April 15 – 17, 2016 Fairmont Chicago Millennium Park • Chicago, Illinois The AAP/ASCI/APSA conference is jointly provided by Boston University School of Medicine and AAP/ASCI/APSA. Meeting Program and Abstracts www.jointmeeting.org www.jointmeeting.org Special Events at the 2016 AAP/ASCI/APSA Joint Meeting Friday, April 15 Saturday, April 16 ASCI President’s Reception ASCI Food and Science Evening 6:15 – 7:15 p.m. 6:30 – 9:00 p.m. Gold Room The Mid-America Club, Aon Center ASCI Dinner & New Member AAP Member Banquet Induction Ceremony (Ticketed guests only) (Ticketed guests only) 7:00 – 10:00 p.m. 7:30 – 9:45 p.m. Imperial Ballroom, Level B2 Rouge, Lobby Level How to Solve a Scientific Puzzle: Speaker: Clara D. Bloomfield, MD Clues from Stockholm and Broadway The Ohio State University Comprehensive Cancer Center Speaker: Joe Goldstein, MD APSA Welcome Reception & University of Texas Southwestern Medical Center at Dallas Presidential Address APSA Dinner (Ticketed guests only) 9:00 p.m. – Midnight Signature Room, 360 Chicago, 7:30 – 9:00 p.m. John Hancock Center (off-site) Rouge, Lobby Level Speaker: Daniel DelloStritto, APSA President Finding One’s Scientific Niche: Musings from a Clinical Neuroscientist Speaker: Helen Mayberg, MD, Emory University Dessert Reception (open to all attendees) 10:00 p.m. – Midnight Imperial Foyer, Level B2 Sunday, April 17 APSA Future of Medicine and www.jointmeeting.org Residency Luncheon Noon – 2:00 p.m. Rouge, Lobby Level 2 www.jointmeeting.org Program Contents General Program Information 4 Continuing Medical Education Information 5 Faculty and Speaker Disclosures 7 Scientific Program Schedule 9 Speaker Biographies 16 Call for Nominations: 2017 Harrington Prize for Innovation in Medicine 26 AAP/ASCI/APSA Joint Meeting Faculty 27 Award Recipients 29 Call for Nominations: 2017 Harrington Scholar-Innovator Award 31 Call for Nominations: George M. -
Melbourne Health Annual Report 2007/08
Melbourne Health Annual Report 2007/08 1BTTJPOGPS $BSJOH"DIJFWJOH UIF&YUSBPSEJOBSZ PROFILE Prof Graham Brown There was none more deserving of the 2007 Melbourne Health Chairman’s Award than Prof Graham Brown. Prof Brown, an acclaimed infectious diseases physician, researcher and teacher, is passionate about public health and is highly regarded by colleagues for his outstanding leadership, intellect and ethical standards. Prof Brown this year took up the role of Foundation Director of the Nossal Institute for Global Health and Foundation Chair in Global Health at the University of Melbourne. Prof Brown’s association with Melbourne Health began as a medical student at RMH, then as a resident, medical registrar, consultant and ultimately, as the James Stewart Professor of Medicine. In 1996, he established the hospital’s renowned Victorian Infectious Diseases Service, taking responsibility for the many services transferred from the former Fairfi eld Infectious Diseases Hospital. “It was almost by chance that I ended up in Medical School, and incredible good fortune to be trained in the environment of RMH that valued academic- based medicine with strong links to Melbourne University. The mentorship, the collegiality, the pursuit of excellence, the challenging students, the superb nursing and allied health staff, and above all, the concern and care for every patient, set very high standards and a benchmark for my career in medicine.” CONTENT 43 Financial Statements 44 Operating Statement 45 Balance Sheet Contents 46 Cash Flow Statement 2 Chairman’s -
The Role of Small Rnas in C4 Photosynthesis
The Role of Small RNAs in C4 Photosynthesis E.L.C. Gage Magdalene College University of Cambridge A thesis submitted for the degree of Doctor of Philosophy June 2012 Contents Declaration ........................................................................................................................... i Acknowledgements ............................................................................................................ iii Abstract ............................................................................................................................... v List of Figures .................................................................................................................... vii List of Tables .................................................................................................................... viii Abbreviations ..................................................................................................................... ix 1. Introduction ...................................................................................................................... 1 1.1: A Requirement for Improved Crop Productivity ....................................................... 1 1.2: The Effects of Photorespiration ................................................................................. 1 1.3: The C4 Cycle .............................................................................................................. 3 1.4: miRNA Regulation of the C4 Cycle ........................................................................ -
CV Andreas P. M. Weber
Andreas P.M. Weber – Curriculum Vitae Institute of Plant Biochemistry Department of Biology Heinrich-Heine-Universität Phone +49-211-81-12347 Geb. 26.03.01 Fax +49-211-81-13706 D-40225 Düsseldorf [email protected] http://www.plant-biochemistry.hhu.de EDUCATION Institution Major/Area Degree Year University of Würzburg Botany Diploma 1991 University of Würzburg Plant Biology Dr. rer.nat. 1996 University of Cologne Plant Biology Habilitation 2002 APPOINTMENTS 2013 Director, Center for Synthetic Life Sciences (CSL), HHU Düsseldorf 2007- Professor (W3) and Chair, Institute of Plant Biochemistry, Department of Biology, Heinrich-Heine-University, Düsseldorf, Germany 2007-2012 Adjunct Professor of Plant Biology, Department of Plant Biology, Michigan State University 2002-2007 Associate Professor of Plant Biology, Department of Plant Biology Michigan State University 1997-2002 Research Group Leader, Department of Plant Biology University of Cologne, Germany 2000-2001 Visiting Scientist (Honorary Fellow), Department of Botany University of Wisconsin-Madison 1996-1997 Postdoctoral Fellow, Department of Plant Biology University of Cologne, Germany FUNCTIONS IN STRUCTURED RESEARCH PROGRAMS 2016 Deputy Speaker, Coordinated Research Center 1208 “Identity and Dynamics of Membrane Systems” (SFB 1208; http://www.sfb1208.hhu.de/en.html) 2012 - Speaker, Excellence Cluster EXC 1028, Cluster of Excellence on Plant Science (CEPLAS; http://ceplas.eu) 2009 - Speaker, International Graduate Training Group IRTG 1525, iGRAD-Plant (http://www.igrad-plant.hhu.de) RESEARCH INTERESTS Physiology, biochemistry, and molecular biology of solute transport in plant cells; compartmentation of metabolic pathways and metabolic networks; photorespiration; C4 photosynthesis; extremophilic eukaryotes; ‘Omics technologies; synthetic experimental evolution; synthetic biology. CURRICULUM VITAE ANDREAS P.M. -
Daniel Griffith Anderson
DAVID H. KOCH INSTITUTE FOR INTEGRATIVE DANIEL G. ANDERSON CANCER RESEARCH MASSACHUSETTS INSTITUTE OF TECHNOLOGY [email protected] 500 MAIN STREET, BUILDING 76 ROOM 653 CAMBRIDGE, MA 02139 (617) 258-6843 EDUCATION Ph.D. Molecular Genetics. University of California at Davis, CA, December 1997 Dissertation: Biochemical characterization of the initiation of homologous recombination in Escherichia coli. Advisor: Prof. Stephen Kowalczykowski. MS Molecular Genetics. University of California at Davis, CA, June 1995 B.A. Math and Biology double major, University of California at Santa Cruz, September 1992 COLLEGE HONORS Graduate Jastro-Shields Fellowship National Institute of Health Biotechnology Fellowship National Science Foundation Honors University of California at Davis Graduate Fellowship Sigma Xi Biology Honors Society Membership Undergraduate College Honors Highest Honors, Biology Honors in the Senior Requirement in Biology PROFESSIONAL EXPERIENCE Associate Professor, Chemical Engineering, Health Science Technology, David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 2010- Associate Member, Ragon Institute 2015- Associate Member, Broad Institute 2011- Adjunct Investigator, Joslin Institute 2010- Associate Scientific Staff Member, Department of Anesthesiology, Children’s Hospital, Harvard, Boston, MA 2007- Goldblith Associate Professor, 2012-2015 Research Associate. David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 2006 – 2010 Research Associate. Prof. Robert Langer, Mentor. Department of Chemical Engineering, MIT, Cambridge, MA 2003 - 2006 Postdoctoral Fellow. Prof. Robert Langer, Mentor. Department of Chemical Engineering, MIT, Cambridge, MA 1999 - 2003 Postdoctoral Researcher. Prof. Stephen Kowalczykowski, Mentor. Department of Microbiology, UCD, Davis, CA. 1998-1999 Graduate Student. Prof. Stephen Kowalczykowski, Mentor. Department of Microbiology, UCD, Davis, CA. 1992-1997. Undergraduate Researcher. Prof. Jerry Feldman, Mentor. -
Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The
SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland. -
Biochemistry of Recombinational DNA Repair
BiochemistryBiochemistry ofof RecombinationalRecombinational DNADNA Repair:Repair: CommonCommon ThemesThemes StephenStephen KowalczykowskiKowalczykowski UniversityUniversity ofof California,California, DavisDavis •Overview of genetic recombination and its function. •Biochemical mechanism of recombination in Eukaryotes. •Universal features: steps common to all organisms. HomologousHomologous RecombinationRecombination AB ab+ Ab aB+ Genesis:Genesis: ScienceScience andand thethe BeginningBeginning ofof TimeTime How does recombination occur? And why? DNADNA ReplicationReplication CanCan ProduceProduce dsDNAdsDNA BreaksBreaks andand ssDNAssDNA GapsGaps RepairRepair ofof DNADNA BreaksBreaks Non-Homologous Homologous End-Joining (NHEJ) Recombination (HR) (error-prone) (error-free) dsDNA Break-Repair Synthesis-Dependent ssDNA Annealing (DSBR) Strand-Annealing (SSA) (SDSA) DoubleDouble--StrandStrand DNADNA BreakBreak RepairRepair 5' 3' 3' 5' + 3' 5' 5' 3' Initiation 1 5' 3' Helicase and/or 3' 5' nuclease 2 5' 3' 3' 3' 3' 5' Homologous Pairing & DNA Strand 3 Exchange 3' 5' 5' 3' RecA-like protein 5' 3' Accessory proteins 3' 3' 5' 4 3' 5' 5' 3' 5' 3' 3' 5' DNA Heteroduplex 5 Branch migration Extension proteins 3' 5' 5' 3' 5' 3' 3' 5' Resolution 6 Resolvase Spliced Patched ProteinsProteins InvolvedInvolved inin RecombinationalRecombinational DNADNA RepairRepair E. coli Archaea S. cerevisiae Human Initiation RecBCD -- -- -- SbcCD Mre11/Rad50 Mre11/Rad50/Xrs2 Mre11/Rad50/Nbs1 RecQ Sgs1(?) Sgs1(?) RecQ1/4/5 LM/WRN(?) RecJ -- ExoI ExoI UvrD -- Srs2 -- Homologous Pairing RecA RadA Rad51 Rad51 & DNA Strand SSB SSB/RPA RPA RPA Exchange RecF(R) RadB/B2/B3(?) Rad55/57 Rad51B/C/D/Xrcc2/3 RecO -- Rad52 Rad52 -- -- Rad59 -- -- Rad54 Rad54/Rdh54 Rad54/54B Brca2 DNA Heteroduplex RuvAB Rad54 Rad54 Rad54 Extension RecG -- -- RecQ Sgs1(?) RecQL/4/5 LM/WRN(?) Resolution RuvC Hjc/Hje -- -- -- -- Mus81/Mms4 Mus81/Mms4 ProteinsProteins InvolvedInvolved inin RecombinationalRecombinational DNADNA RepairRepair 5' 3' E. -
Uk Plant Science Research Strategy a Green Roadmap for the Next Ten Years Contents
UK PLANT SCIENCE RESEARCH STRATEGY A GREEN ROADMAP FOR THE NEXT TEN YEARS CONTENTS Foreword . 1 Introduction . 3 Context . 4 Deliverables . .5 1 Securing. a Pipeline of Transformative Discoveries . 5 2 Strategic. Research to Solve Grand Challenges . .8 3 Innovation. 11 4 Diverse. People and Skills . .18 5 National. Infrastructure . 20 6 International. Landscape . .21 List of Recommendations . 23 Appendix 1: List of people consulted . .25 FOREWORD In many ways the idea of a national strategy I also held a workshop with twenty independent is counterintuitive – science is global and research fellows . I am extremely grateful to more than ever we need to be working across everyone who gave their time and thoughtful national boundaries to solve the enormous input during a very challenging period of environmental and societal challenges that we national lockdown . The issues we discussed face . However, to collaborate more effectively in revolved around what plant science research the international arena we first need increased can and should contribute to society, and what investment and better co-ordination across the mechanisms are needed to ensure effective UK . In April 2020, following discussions with delivery of those contributions . After the colleagues, I proposed a community-driven consultation, I distilled many pages of informal approach to develop a plant science research notes into a two page summary of the core strategy for the UK . I engaged with no personal messages that would underpin the strategy . In or professional agenda, no vested interest and the second phase, this summary was circulated an open mind1 . Melanie Welham, Executive to all consultees, with a request to consult more Chair of the UK Biotechnology and Biological widely within their local constituency and to Sciences Research Council (BBSRC), part feedback any further comments .