Future Skills for the Life Sciences: Conference Report March 2019
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Second Quarter 2017
Press release Second quarter 2017 Issued: Wednesday, 26 July 2017, London U.K. GSK delivers further progress in Q2 and sets out new priorities for the Group Q2 sales of £7.3 billion, +12% AER, +3% CER Total loss per share of 3.7p, +59% AER, +29% CER; Adjusted EPS of 27.2p, +12% AER, -2% CER Financial highlights • Pharmaceutical sales, £4.4 billion, +12% AER, +3% CER, Vaccines sales, £1.1 billion, +16% AER, +5% CER, Consumer Healthcare sales, £1.9 billion,+10% AER, flat at CER • Group operating margin 28.5%; Pharmaceuticals 33.6%; Vaccines 33.7%; Consumer 17.7% • Total Q2 loss per share of 3.7p reflecting charges resulting from increases in the valuation of Consumer and HIV businesses and new portfolio choices • Updated 2017 guidance: Adjusted EPS growth now expected to be 3% to 5% CER reflecting impact of Priority Review Voucher • H1 Free Cash Flow £0.4 billion (H1 2016: £0.1 billion) • 19p dividend declared for Q2; continue to expect 80p for FY 2017 Product and pipeline highlights • New product sales of £1.7 billion, +62% AER, +47% CER • HIV two drug regimen (dolutegravir and rilpivirine) filed for approval in US and EU • Shingrix filed for approval in Japan • FDA approval received for subcutaneous Benlysta for treatment of SLE New business priorities to 2020 • New priorities to strengthen innovation, improve performance and build trust • Pharmaceutical R&D pipeline reviewed with target over time to allocate 80% of capital to priority assets in two current (Respiratory and HIV/infectious diseases) and two potential (Oncology and Immuno-inflammation) -
The Story of a Rising Race
This is a reproduction of a library book that was digitized by Google as part of an ongoing effort to preserve the information in books and make it universally accessible. https://books.google.com Thestoryofarisingrace JamesJeffersonPipkin COUNCIIA.W.H. SOMENOTEDEDUCATORSOFRACE.THECOLORED T.WASHINGTON.BOOKER WESLHYHOFFMAN.JOHN THE STORY OF A RISING RACE THE NEGRO IN REVELATION, IN HISTORY AND IN CITIZENSHIP WHAT THE RACE HAS DONE AND IS DOING ARMS, ARTS, LETTERS, THE PULPIT, THE FORUM, THE SCHOOL, THE MARTS OF TRADE WITH THOSE MIGHTY WEAPONS IN THE BATTLE OF LIFE THE SHOVEL AND THE HOE A MESSAGE TO ALL MEN THAT HE IS IN THE WAY TO SOLVE THE RACE PROBLEM EOR HIMSELF REV. J . J . WPKIK WITH INTRODUCTION BY GEN. JOHN B. GORDON Former Major-General Confederate Army, United States Senator from Georgia. Ex-Commander United Confederate Veterans, Author "War Reminiscences," Etc. ^ CatJogua Proe. (JOPYHTUHT, 1902, BY N. ]).THOMP»ON PUBLISHING OOMPAN V NOT A TERM OF REPROACH. Supposing that this term (negro) was originally used as a phrase of contempt, is it not wilh us to elevate it? How often has it not happened that names originally given in reproach have been afterward adopted as a title of honor by those against whom they were used, as Methodists, Quakers, etc. t But as a proof that no unfavorable signification attached to the word when first employed, I may mention that long before the slave trade began travelers found the blacks on the coast of Africa preferring to be called Negroes. And in all the pre- slave trade literature the word was spelled with a capital N. -
The Academy of Medical Sciences Review 2006 Fmedsci Contents
The Academy of Medical Sciences Review 2006 FMedSci Contents 1 The Academy’s objectives and ambitions for medical science 2 A message from our President 4 Executive Director’s report 6 The strength of our Fellowship 8 How we work 10 Progress through partnership 12 Celebrating science 14 Advancing medical science and infl uencing policy 16 Building trust in science 18 Working in partnership with industry 20 The impact of research 22 Creating the next generation of medical scientists 24 Financial information 25 The Academy offi ce 14 16 18 20 22 The Academy’s objectives and ambitions for medical science The Academy of Medical Sciences promotes advances in medical science and campaigns to ensure these are converted as quickly as possible into healthcare benefi ts for society. Our 850 Fellows are the UK’s leading medical scientists from hospitals and general practice, academia, industry and the public service. Our Fellows are central to all we do. The excellence of their science, their contribution to medicine and society and the diversity of their achievements are refl ected throughout this review. The Academy seeks to play a pivotal role in determining the future of medical science in the UK, and the benefi ts that society will enjoy in years to come. We champion the UK’s strengths in medical science, including the unique opportunities for research aff orded by the NHS, encourage the implementation of new ideas and solutions – often through novel partnerships, promote careers and capacity building and help to remove barriers to progress. Throughout all our work the Academy strives to demonstrate our key attributes of excellence, independence, leadership, diversity and fl exibility. -
Stem Strategy
SUCCESS THROUGH STEM STEM STRATEGY In response to the ‘Report of the STEM Review’ HELPING TO EMPOWER FUTURE GENERATIONS THROUGH SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS TO GROW A DYNAMIC, INNOVATIVE ECONOMY 2011 CONTENTS 1. INTRODUCTION 4 2. CONTEXT 5 3. THE ROLE OF THE DEMAND SIDE 8 4. THE ROLE OF THE SUPPLY SIDE 10 5. RECOMMENDATIONS FOR ACTION 15 6. STRUCTURES FOR IMPLEMENTATION 23 7. CONCLUSION AND PRIORITY ACTIONS 25 ANNEX A – Existing Government STEM Activity ANNEX B – Government STEM Action Plan 1. INTRODUCTION Commissioned by the Department for Employment The Report contains 20 recommendations grouped and Learning (DEL) and the Department of Education under four ‘imperatives’. (DE), the review of Science, Technology, Engineering • Imperative 1 - Business must take the lead and Mathematics (STEM) commenced formally on in promoting STEM. 29 June 2007. Chaired by Dr Hugh Cormican, founder and former Chief Executive of Andor Technologies • Imperative 2 - The key constraints in the STEM Ltd., the steering group comprised representatives artery must be alleviated. from business, government and academia and the Programme Manager for the review was Dr Alan Blair, • Imperative 3 - There needs to be increased from the Association of NI Colleges (now Colleges NI). flexibility in the provision of STEM education. Three working groups reported to the steering group, • Imperative 4 - Government must better each of which was responsible for taking forward a coordinate its support for STEM. key strand of the Review. These working groups ensured This STEM Strategy forms Government’s response a focus on the respective roles of business, education, to the ‘Report of the STEM Review’. -
Third Annual World Congress on the Insulin Resistance Syndrome Atherothrombotic Disease
Reviews/Commentaries/Position Statements PERSPECTIVES ON THE NEWS Third Annual World Congress on the Insulin Resistance Syndrome Atherothrombotic disease ZACHARY T. BLOOMGARDEN, MD thalamic “clock,” which generates protein signals feeding back to create rhythmic behaviors and metabolic changes. Rhyth- his is the second of three articles re- structure, coagulation, and platelets in a mic mRNA expression of clock genes and viewing presentations at the 3rd An- prothrombotic direction (3). adipokines can also be demonstrated in T nual World Congress on the Insulin It is not apparent why insulin resis- mouse visceral adipose tissue, with adi- Resistance Syndrome, San Francisco, Cal- tance should be linked to atherosclerosis. ponectin and resistin responses both at- ifornia, 17–19 November 2005. The thrifty genotype hypothesis suggests tenuated in obese mice. Grant showed an that there is a survival advantage to insu- animal model in which pioglitazone im- proved hepatic rhythmicity. Thus, light, Diabetes and vascular disease lin resistance during periods of feast alter- as well as other stimuli such as ambient At a symposium cosponsored by the In- nating with famine (4), but that chronic ternational Society of Diabetes and Vascu- exposure to high nutrient intake converts temperature, acts via the suprachiasmatic lar Disease (www.dvdres.com), Peter the organism to the phenotype of insulin nucleus to send signals to adipocytes, the Grant (Leeds, U.K.) discussed the role of resistance sydrome and diabetes, with en- endothelium, liver, fibroblasts, cardiac insulin signaling pathways in acute coro- ergy preferentially stored in the liver and myocytes, and multiple other tissues, reg- nary syndrome (ACS), pointing out that in fat and with the clustering of risk mark- ulating reproductive, metabolic, and be- type 2 diabetes is characterized by fasting ers we have come to identify with insulin havioral aspects of life. -
Jeremy Farrar
FEATURE The BMJ THE BMJ INTERVIEW BMJ: first published as 10.1136/bmj.n459 on 19 February 2021. Downloaded from [email protected] Cite this as: BMJ 2021;372:n459 http://dx.doi.org/10.1136/bmj.n459 Jeremy Farrar: Make vaccine available to other countries as soon as Published: 19 February 2021 our most vulnerable people have received it The SAGE adviser and Wellcome Trust director tells Mun-Keat Looi how the UK government acted too slowly against the pandemic, about the perils of vaccine nationalism, and why he is bullish about controlling covid variants Mun-Keat Looi international features editor “Once the UK has vaccinated our most vulnerable among healthcare workers. We had no human communities and healthcare workers we should make immunity, no diagnostics, no treatment, and no vaccines available to other countries,” insists the vaccines. infectious disease expert Jeremy Farrar. This could Every country should have acted then. Singapore, avert further public health and economic disaster, China, and South Korea did. Yet most of Europe and he says, describing it as “enlightened self-interest, North America waited until the middle of March, and as well as the right ethical thing to do.” that defined the first wave. Countries including the In April 2020, soon after the first UK lockdown began, UK were unwilling to act early, before they felt Farrar predicted that the UK would have one of the comfortable; were unwilling to go deeper than they worst covid-19 death rates in Europe. As a member thought they had to; and were unwilling to keep of the Scientific Advisory Group for Emergencies restrictions in place for as long as was needed. -
Connecting Immunology
CONNECTING IMMUNOLOGY IN THE TIME OF COVID-19 BSI VIRTUAL CONFERENCE 1-2 DECEMBER 2020 CONNECTINGLOGY NO VID-19 MU OF CO IM TIME IN THE CONNECTING CONNECTING IMMUNOLOGY IN THE TIME OF COVID-19 2 IMMUNOLOGY IN THE TIME OF COVID-19 Welcome On behalf of the BSI’s Congress Committee, I would like to welcome you all to the British Society for Immunology’s virtual conference ‘Connecting immunology in the time of COVID-19’. This is the BSI’s first ever virtual conference at this scale and our committee have worked hard to develop a diverse programme of plenary and parallel sessions covering many of the hot topics within immunology, which we hope will appeal to delegates. With our cutting-edge two-day agenda coupled with our interactive online platform, we aim to bring together immunologists from the UK and worldwide, providing attendees with the latest research developments from Gary Entrican internationally acclaimed leaders in their field. We’re honoured to welcome a number of high-profile speakers including our two keynote presenters from the US, Garry Nolan and Akiko Iwasaki. Additionally, we are privileged to be joined by Sir Patrick Vallance, the Chief Scientific Adviser to the UK Government, who will speak in our COVID-19 themed plenary session alongside Paul Moss, the lead for the UK Coronavirus Immunology Consortium. Among the many other highlights of our programme, I would particularly recommend you attend our Bright Sparks sessions on the first morning, featuring ground-breaking work from promising early career researchers. Additionally, our Coronavirus Panel Discussion on the second afternoon promises to be a fascinating exchange of views on how immunology has fed into the pandemic response. -
Evidence Synthesis on the EU-UK Relationship on Research and Innovation January 2018
Evidence synthesis on the EU-UK relationship on research and innovation January 2018 1. Introduction The Royal Society and the Wellcome Trust have undertaken a rapid evidence synthesis on the EU-UK research and innovation relationship as part of their Future Partnership Project. Organisations and individuals were invited to submit evidence and analyses for inclusion. Evidence was also gathered through internet searches to ensure an inclusive approach. The Annex is a summary of the methods. Two questions were used in gathering evidence and in determining the material in scope: 1. What incentives, infrastructure and mechanisms can be accessed by research and innovation organisations, funders and individuals in Member States to support collaborations? 2. How do Member States currently use and benefit from these and how might they be affected by Brexit? This paper is a synthesis of the evidence and covers funding, infrastructures, mobility, collaboration and regulation, with a focus on links between the EU and the UK. 2. Overview of the evidence base A few major reports were of particular relevance; the Royal Society’s three reports on the role of the EU in UK research and innovation and two reports commissioned from Technopolis Group by UK organisations, on the role of EU funding in UK research and innovation and the impact of collaboration: the value of UK medical research to EU science and health1,2. These documents were often referenced in other submissions. A report from the Lords Science and Technology Committee’s inquiry on EU Membership and UK Science also summarises many sources of evidence relevant to this synthesis. -
Janet Thornton / 19 July 2018
Oral History: Janet Thornton / 19 July 2018 DISCLAIMER The information contained in this transcript is a textual representation of the recoded interview which took place on 2018-07-19 as part of the Oral Histories programme of the EMBL Archive. It is an unedited, verbatim transcript of this recorded interview. This transcript is made available by the EMBL Archive for free reuse for research and personal purposes, providing they are suitably referenced. Please contact the EMBL Archive ([email protected]) for further information and if you are interested in using material for publication purposes. Some information contained herein may be work product of the interviewee and/or private conversation among participants. The views expressed herein are solely those of the interviewee in his private capacity and do not necessary reflect the views of the EMBL. EMBL reserves the right not to be responsible for the topicality, accuracy, completeness or quality of the information provided. Liability claims regarding damage caused by the use of any information provided, including any kind of information which is incomplete or incorrect, will therefore be rejected. 2 2018_07_19_JanetThornton Key MG: Mark Green, former head of Administration at EMBL-EBI JT: Participant, Janet Thornton, former Director of EMBL-EBI and current EMBL-EBI Research Group Leader [??? At XX:XX] = inaudible word or section at this time MG: My name is Mark Green. This is Thursday 19th July 2018 and I’m in the Pompeian Room in Hinxton Hall on the Wellcome Genome Campus where EMBL-EBI is based and I’m about to do an interview as part of the oral histories programme of the EMBL Archive, with Janet Thornton, and I’d just like to ask Janet to introduce herself and to say a bit about her life before EMBL. -
Francis Crick Institute-CS-JB080719.Indd
The Francis Crick Institute THE FRANCIS CRICK INSTITUTE The Crick is a landmark partnership between three of the UK’s largest funders of biomedical research: the Medical Research Council, Cancer Research UK and the Wellcome Trust, and three of its leading universities: UCL, Imperial College London and King’s College London. This represents an unprecedented joining of forces to tackle major scientific problems and generate solutions to the emerging health challenges of the 21st century. Business Challenge: The VIRTUS Solution: The Crick is being built in central London, where space is at a Collaboration is at the heart of the Crick’s vision. Its work premium. It was decided, early in the planning process, that will help to understand why disease develops and to find most of the Crick’s data would need to be stored off-site. new ways to diagnose, prevent and treat a range of illnesses However, the institute realised there were major benefits to – such as cancer, heart disease and stroke, infections and sharing resources with other institutions, particularly in terms neurodegenerative diseases. The Crick will bring together of scientific analysis. As the Crick’s plans developed, a number outstanding scientists from all disciplines, carrying out research of institutions – both within the original partners and more that will help improve the health and quality of people’s lives, broadly - had similar requirements and identified the same and keeping the UK at the forefront of medical innovation. potential for collaboration in having a colocated shared data centre. “The Crick has been proud to take a leading role in support of Janet. -
The Francis Crick Institute
Clinical Medicine 2017 Vol 17, No 2: 105–7 PROFESSIONAL ISSUES T h e F r a n c i s C r i c k I n s t i t u t e A u t h o r s : K e i t h P e t e r s A a n d J i m S m i t h B The Francis Crick Institute Laboratory, opened in 2016, is sup- is within easy reach of GlaxoSmithKine (GSK) and Astra ported by the Medical Research Council, Cancer Research UK, Zeneca’s principal research laboratories in Stevenage and the Wellcome Trust, and University College London, King’s Col- Cambridge, respectively. lege London and Imperial College London. The emphasis on But in order to justify investment on the scale required, the research training and early independence of gifted scientists new institute needed to be more than a simple translocation to ABSTRACT in a multidisciplinary environment provides unique opportuni- a new site. ties for UK medical science, including clinical and translational After discussion and negotiation, the MRC, Cancer Research research. UK (CRUK), the Wellcome Trust and University College London (UCL) created a partnership: CRUK’s London Research K E Y W O R D S : MRC , CRUK , Wellcome , Crick , UCL , King’s , Imperial Institute (LRI) would join the NIMR, with researchers from UCL contributing expertise in the physical and clinical sciences. Importantly, the Crick was not simply to be a merger The Francis Crick Institute has been referred to as the most of LRI and NIMR but a new entity with a different ethos – a significant development in UK biomedical science for a multidisciplinary institute with a substantial new investment in generation. -
Science and Stormont Monday 10 October 2016 Antimicrobial Resistance
Science and Stormont Monday 10 October 2016 Antimicrobial Resistance Programme Senate Chamber & the Long Gallery, Parliament Buildings, Stormont 12:30pm : Registrations, exhibition & light refreshments 3:45pm : TEA BREAK The Long Gallery 4:15pm : Panel two 1:45pm : Proceed to the Senate Chamber for the Afternoon Tackling Antimicrobial Resistance - Presentations A Multidisciplinary Approach 2:00pm : Opening Address Dr Patrick Dunlop, Lecturer in Engineering Naomi Long MLA, Chair, Northern Ireland Materials (NIBEC), Ulster University and Chair NI Assembly All-Party Group on Science and AMR Network Technology Natural alternatives to antibiotics Prof Paul Ross, Head of College of Science 2:05pm : Welcome and introduction Engineering and Food Science, University College Prof Sir John Holman, President, Royal Society of Cork Chemistry Tackling AMR, an Industry Perspective 2:15pm : Together against the bugs: scientific and political Dr Robert Grundy, Co-Chair Life and Health leadership on a mission Sciences, Department for the Economy’s MATRIX Dr Michael McBride, Chief Medical Officer, panel Northern Ireland 5:15pm : MLA Panel 2:40pm : Session Chair Naomi Long MLA, Chair, Northern Ireland Dr Geetha Srinivasan, Queen’s University Belfast, Assembly All-Party Group on STEM and member, Royal Society of Chemistry Steve Aiken OBE MLA, Vice Chair, All-Party Group 2:45pm : Panel one on STEM Antibiotic use in care homes Caoimhe Archibald MLA, Vice Chair, All-Party Prof Michael Tunney, Chair in Clinical Pharmacy, Group on STEM School of Pharmacy, Queen’s