The UK's Role in Global Research
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Wellcome Trust Annual Report and Financial Statements 2017 Contents
Annual Report and Financial Statements 2017 2 Wellcome Trust Annual Report and Financial Statements 2017 Contents Report from the Chair and the Director 5 Trustee’s Report 8 What we do 8 Review of Charitable Activities 9 Review of Investment Activities 18 Financial Review 29 Structure and Governance 34 Risk Management 37 Remuneration Report 40 Audit Committee Report 43 Independent Auditor’s Report 45 Financial Statements 58 Consolidated Statement of Financial Activities 58 Consolidated Balance Sheet 59 Statement of Financial Activities of the Trust 60 Balance Sheet of the Trust 61 Consolidated Cash Flow Statement 62 Notes to the Financial Statements 63 Reference and Administrative Details 117 3 Wellcome Trust Annual Report and Financial Statements 2017 “ At Wellcome, we believe in the power of ideas to improve health” Jeremy Farrar Director 4 Wellcome Trust Annual Report and Financial Statements 2017 Report from the Chair and the Director “Our core approach is funding people to explore great ideas, at every step of the way from discovery to impact” At Wellcome, we believe in the power of ideas to improve cause of maternal mortality in the world. It also includes health. Funded from our independent investment portfolio, supporting research in the humanities and social sciences, we support thousands of scientists and researchers in more such as a project which this year published ethical guidelines than 70 countries, as well as innovators, educators and artists. for involving pregnant women in Zika vaccine research. Together, we take on big problems, fuel imaginations and spark And resources like the Human Induced Pluripotent Stem Cell debate, working always to achieve better health for everyone. -
The Electron Microscopy Science Technology Platform at the Francis
The Francis Crick Institute is a The Electron biomedical discovery institute Microscopy dedicated to understanding the fundamental biology underlying Science health and disease. Its work Technology is helping to understand why disease develops and to translate Platform at discoveries into new ways to the Francis prevent, diagnose and treat illnesses such as cancer, heart Crick Institute disease, stroke, infections, and Lucy Collinson neurodegenerative diseases. An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, University College London, Imperial College London and King’s College London. The Crick was formed in 2015, with many of the Crick’s scientists joining from two ‘parent’ institutes, the MRC’s National Institute for Medical Research and Cancer Research UK’s London Research Institute, and in 2016 it moved into a brand new state-of- the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe. © Nick Guttridge 4 ISSUE 46 JUNE 2017 5 Each microscope room is a six-sided shielded box, • The Phenom-World DelPhi benchtop SEM with walls that contain complex metallic layers has an integrated fluorescence microscope to attenuate DC fields, and an active cancellation for correlative imaging system to attenuate AC fields. Under each • The FEI Twin 120 kV TEM has a cryo stage for microscope is a concrete platform, cast in place, and screening vitrified macromolecular samples supported by air springs that remove environmental prior to imaging on 200 kV and 300 kV TEMs vibration to <1 Hz. -
From Coalition to Commons: Plan S and the Future of Scholarly Communication
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Copyright, Fair Use, Scholarly Communication, etc. Libraries at University of Nebraska-Lincoln 2019 From Coalition to Commons: Plan S and the Future of Scholarly Communication Rob Johnson Research Consulting Follow this and additional works at: https://digitalcommons.unl.edu/scholcom Part of the Intellectual Property Law Commons, Scholarly Communication Commons, and the Scholarly Publishing Commons Johnson, Rob, "From Coalition to Commons: Plan S and the Future of Scholarly Communication" (2019). Copyright, Fair Use, Scholarly Communication, etc.. 157. https://digitalcommons.unl.edu/scholcom/157 This Article is brought to you for free and open access by the Libraries at University of Nebraska-Lincoln at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Copyright, Fair Use, Scholarly Communication, etc. by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Insights – 32, 2019 Plan S and the future of scholarly communication | Rob Johnson From coalition to commons: Plan S and the future of scholarly communication The announcement of Plan S in September 2018 triggered a wide-ranging debate over how best to accelerate the shift to open access. The Plan’s ten principles represent a call for the creation of an intellectual commons, to be brought into being through collective action by funders and managed through regulated market mechanisms. As it gathers both momentum and critics, the coalition must grapple with questions of equity, efficiency and sustainability. The work of Elinor Ostrom has shown that successful management of the commons frequently relies on polycentricity and adaptive governance. The Plan S principles must therefore function as an overarching framework within which local actors retain some autonomy, and should remain open to amendment as the scholarly communication landscape evolves. -
Structure of Human Aspartyl Aminopeptidase Complexed With
Chaikuad et al. BMC Structural Biology 2012, 12:14 http://www.biomedcentral.com/1472-6807/12/14 RESEARCH ARTICLE Open Access Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family Apirat Chaikuad1, Ewa S Pilka1, Antonio De Riso2, Frank von Delft1, Kathryn L Kavanagh1, Catherine Vénien-Bryan2, Udo Oppermann1,3 and Wyatt W Yue1* Abstract Backround: Aspartyl aminopeptidase (DNPEP), with specificity towards an acidic amino acid at the N-terminus, is the only mammalian member among the poorly understood M18 peptidases. DNPEP has implicated roles in protein and peptide metabolism, as well as the renin-angiotensin system in blood pressure regulation. Despite previous enzyme and substrate characterization, structural details of DNPEP regarding ligand recognition and catalytic mechanism remain to be delineated. Results: The crystal structure of human DNPEP complexed with zinc and a substrate analogue aspartate-β- hydroxamate reveals a dodecameric machinery built by domain-swapped dimers, in agreement with electron microscopy data. A structural comparison with bacterial homologues identifies unifying catalytic features among the poorly understood M18 enzymes. The bound ligands in the active site also reveal the coordination mode of the binuclear zinc centre and a substrate specificity pocket for acidic amino acids. Conclusions: The DNPEP structure provides a molecular framework to understand its catalysis that is mediated by active site loop swapping, a mechanism likely adopted in other M18 and M42 metallopeptidases that form dodecameric complexes as a self-compartmentalization strategy. Small differences in the substrate binding pocket such as shape and positive charges, the latter conferred by a basic lysine residue, further provide the key to distinguishing substrate preference. -
Stem Strategy
SUCCESS THROUGH STEM STEM STRATEGY In response to the ‘Report of the STEM Review’ HELPING TO EMPOWER FUTURE GENERATIONS THROUGH SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS TO GROW A DYNAMIC, INNOVATIVE ECONOMY 2011 CONTENTS 1. INTRODUCTION 4 2. CONTEXT 5 3. THE ROLE OF THE DEMAND SIDE 8 4. THE ROLE OF THE SUPPLY SIDE 10 5. RECOMMENDATIONS FOR ACTION 15 6. STRUCTURES FOR IMPLEMENTATION 23 7. CONCLUSION AND PRIORITY ACTIONS 25 ANNEX A – Existing Government STEM Activity ANNEX B – Government STEM Action Plan 1. INTRODUCTION Commissioned by the Department for Employment The Report contains 20 recommendations grouped and Learning (DEL) and the Department of Education under four ‘imperatives’. (DE), the review of Science, Technology, Engineering • Imperative 1 - Business must take the lead and Mathematics (STEM) commenced formally on in promoting STEM. 29 June 2007. Chaired by Dr Hugh Cormican, founder and former Chief Executive of Andor Technologies • Imperative 2 - The key constraints in the STEM Ltd., the steering group comprised representatives artery must be alleviated. from business, government and academia and the Programme Manager for the review was Dr Alan Blair, • Imperative 3 - There needs to be increased from the Association of NI Colleges (now Colleges NI). flexibility in the provision of STEM education. Three working groups reported to the steering group, • Imperative 4 - Government must better each of which was responsible for taking forward a coordinate its support for STEM. key strand of the Review. These working groups ensured This STEM Strategy forms Government’s response a focus on the respective roles of business, education, to the ‘Report of the STEM Review’. -
A Critical Base Pair in K-Turns That Confers Folding Characteristics and Correlates with Biological Function
ARTICLE Received 16 Apr 2014 | Accepted 2 Sep 2014 | Published 29 Oct 2014 DOI: 10.1038/ncomms6127 OPEN A critical base pair in k-turns that confers folding characteristics and correlates with biological function Scott A. McPhee1, Lin Huang1 & David M.J. Lilley1 Kink turns (k-turns) are widespread elements in RNA that mediate tertiary contacts by kinking the helical axis. We have found that the ability of k-turns to undergo ion-induced folding is conferred by a single base pair that follows the conserved AG pairs, that is, the 3b3n position. A Watson–Crick pair leads to an inability to fold in metal ions alone, while 3n ¼ Gor3b¼ C (but not both) permits folding. Crystallographic study reveals two hydrated metal ions coordinated to O6 of G3n and G2n of Kt-7. Removal of either atom impairs Mg2 þ - induced folding in solution. While SAM-I riboswitches have 3b3n sequences that would predispose them to ion-induced folding, U4 snRNA are strongly biased to an inability to such folding. Thus riboswitch sequences allow folding to occur independently of protein binding, while U4 should remain unfolded until bound by protein. The empirical rules deduced for k-turn folding have strong predictive value. 1 Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, UK. Correspondence and requests for materials should be addressed to D.M.J.L. (email: [email protected]). NATURE COMMUNICATIONS | 5:5127 | DOI: 10.1038/ncomms6127 | www.nature.com/naturecommunications 1 & 2014 Macmillan Publishers Limited. -
Jeremy Farrar
FEATURE The BMJ THE BMJ INTERVIEW BMJ: first published as 10.1136/bmj.n459 on 19 February 2021. Downloaded from [email protected] Cite this as: BMJ 2021;372:n459 http://dx.doi.org/10.1136/bmj.n459 Jeremy Farrar: Make vaccine available to other countries as soon as Published: 19 February 2021 our most vulnerable people have received it The SAGE adviser and Wellcome Trust director tells Mun-Keat Looi how the UK government acted too slowly against the pandemic, about the perils of vaccine nationalism, and why he is bullish about controlling covid variants Mun-Keat Looi international features editor “Once the UK has vaccinated our most vulnerable among healthcare workers. We had no human communities and healthcare workers we should make immunity, no diagnostics, no treatment, and no vaccines available to other countries,” insists the vaccines. infectious disease expert Jeremy Farrar. This could Every country should have acted then. Singapore, avert further public health and economic disaster, China, and South Korea did. Yet most of Europe and he says, describing it as “enlightened self-interest, North America waited until the middle of March, and as well as the right ethical thing to do.” that defined the first wave. Countries including the In April 2020, soon after the first UK lockdown began, UK were unwilling to act early, before they felt Farrar predicted that the UK would have one of the comfortable; were unwilling to go deeper than they worst covid-19 death rates in Europe. As a member thought they had to; and were unwilling to keep of the Scientific Advisory Group for Emergencies restrictions in place for as long as was needed. -
Living Healthier for Longer Sharing Data Saves Lives
News from the Medical Research Council network Spring 2014 Leading science for better health MEASUREto How some MRC scientific workshops are making custom-made kit to enable pioneering research Living healthier for longer Supporting innovative ageing research through the Lifelong Health and Wellbeing initiative Sharing data saves lives Opinions from two MRC researchers Network can also be downloaded as a PDF at: www.mrc.ac.uk/network CONTENTS NEWS News COMMENT FROM £39.1m for improving data research 3 £39.1m for improving Science festival fun 4 John Let’s talk about dementia 7 data research Savill A £32m MRC investment, announced by Universities and Science the MRC Consortium for Medical Microbial Bioinformatics led by Minister David Willetts at the High Performance Computing and Warwick University, the Medical Bioinformatics partnership led People CHIEF EXECUTIVE Big Data Conference in London on 6 February, plus an additional by Imperial College London and University College London £7.1m, is the latest instalment of a £90m funding initiative to Partners which includes the Francis Crick Institute, will also Dr Jane Cope on the power of persuasion 9 In February, the Minister for tackle health and bioinformatics challenges for the advancement support career opportunities for computational scientists, Universities and Science David of medical research. technologists and programme leaders, enhancing the UK’s skills Willetts announced a £32m MRC in this area. investment into improving the UK’s Six major strategic awards will strengthen collaborative links, capability in, and capacity for, improve tools and infrastructure for researchers and support the Mr Willets said: “Making the most of large and complex data is a Latest discoveries medical bioinformatics. -
Evidence Synthesis on the EU-UK Relationship on Research and Innovation January 2018
Evidence synthesis on the EU-UK relationship on research and innovation January 2018 1. Introduction The Royal Society and the Wellcome Trust have undertaken a rapid evidence synthesis on the EU-UK research and innovation relationship as part of their Future Partnership Project. Organisations and individuals were invited to submit evidence and analyses for inclusion. Evidence was also gathered through internet searches to ensure an inclusive approach. The Annex is a summary of the methods. Two questions were used in gathering evidence and in determining the material in scope: 1. What incentives, infrastructure and mechanisms can be accessed by research and innovation organisations, funders and individuals in Member States to support collaborations? 2. How do Member States currently use and benefit from these and how might they be affected by Brexit? This paper is a synthesis of the evidence and covers funding, infrastructures, mobility, collaboration and regulation, with a focus on links between the EU and the UK. 2. Overview of the evidence base A few major reports were of particular relevance; the Royal Society’s three reports on the role of the EU in UK research and innovation and two reports commissioned from Technopolis Group by UK organisations, on the role of EU funding in UK research and innovation and the impact of collaboration: the value of UK medical research to EU science and health1,2. These documents were often referenced in other submissions. A report from the Lords Science and Technology Committee’s inquiry on EU Membership and UK Science also summarises many sources of evidence relevant to this synthesis. -
Janet Thornton / 19 July 2018
Oral History: Janet Thornton / 19 July 2018 DISCLAIMER The information contained in this transcript is a textual representation of the recoded interview which took place on 2018-07-19 as part of the Oral Histories programme of the EMBL Archive. It is an unedited, verbatim transcript of this recorded interview. This transcript is made available by the EMBL Archive for free reuse for research and personal purposes, providing they are suitably referenced. Please contact the EMBL Archive ([email protected]) for further information and if you are interested in using material for publication purposes. Some information contained herein may be work product of the interviewee and/or private conversation among participants. The views expressed herein are solely those of the interviewee in his private capacity and do not necessary reflect the views of the EMBL. EMBL reserves the right not to be responsible for the topicality, accuracy, completeness or quality of the information provided. Liability claims regarding damage caused by the use of any information provided, including any kind of information which is incomplete or incorrect, will therefore be rejected. 2 2018_07_19_JanetThornton Key MG: Mark Green, former head of Administration at EMBL-EBI JT: Participant, Janet Thornton, former Director of EMBL-EBI and current EMBL-EBI Research Group Leader [??? At XX:XX] = inaudible word or section at this time MG: My name is Mark Green. This is Thursday 19th July 2018 and I’m in the Pompeian Room in Hinxton Hall on the Wellcome Genome Campus where EMBL-EBI is based and I’m about to do an interview as part of the oral histories programme of the EMBL Archive, with Janet Thornton, and I’d just like to ask Janet to introduce herself and to say a bit about her life before EMBL. -
The Diamond Light Source
The Diamond Light Source ... a bright future for UK and World science Richard P. Walker, Technical Director What is Diamond ? • The largest scientific investment in the UK for 30 years • A synchrotron light source producing pinpoint UV and X-ray light beams of exceptional brightness • A ‘super microscope’ for new research opportunities into the structure and properties of matter What is Diamond ? • A Power Converter ! 15 MW of electrical power from the grid … 300-500 kW of X-rays … … but most of which only produces unwanted heat; only a fraction is selected for use in experiments. What is Synchrotron Radiation ? SR is electromagnetic radiation emitted when a high energy beam of charged particles (electrons) is deflected by a magnetic field. What’s so special about Synchrotron Radiation ? SR SR is emitted over a wide range of the electromagnetic spectrum, from Infra-red to hard X-rays Any desired radiation wavelength can be produced - enabling a very wide range of scientific and technological applications What’s so special about Synchrotron Radiation ? SR is very intense, and has extremely high brightness (emitted from a small area, with small angular divergence, determined by the properties of the electron beam) High brightness means: - it can be focused to sub-micron spot sizes: possibility of examining extremely small samples or investigating the structure and properties of objects with very fine spatial resolution - experiments can be carried out much more quickly: high through-put of samples or ability to follow chemical and biological reactions in real-time Diamond is a “third-generation” synchrotron radiation source • 1st generation: machines originally built for other purposes e.g. -
Francis Crick Institute-CS-JB080719.Indd
The Francis Crick Institute THE FRANCIS CRICK INSTITUTE The Crick is a landmark partnership between three of the UK’s largest funders of biomedical research: the Medical Research Council, Cancer Research UK and the Wellcome Trust, and three of its leading universities: UCL, Imperial College London and King’s College London. This represents an unprecedented joining of forces to tackle major scientific problems and generate solutions to the emerging health challenges of the 21st century. Business Challenge: The VIRTUS Solution: The Crick is being built in central London, where space is at a Collaboration is at the heart of the Crick’s vision. Its work premium. It was decided, early in the planning process, that will help to understand why disease develops and to find most of the Crick’s data would need to be stored off-site. new ways to diagnose, prevent and treat a range of illnesses However, the institute realised there were major benefits to – such as cancer, heart disease and stroke, infections and sharing resources with other institutions, particularly in terms neurodegenerative diseases. The Crick will bring together of scientific analysis. As the Crick’s plans developed, a number outstanding scientists from all disciplines, carrying out research of institutions – both within the original partners and more that will help improve the health and quality of people’s lives, broadly - had similar requirements and identified the same and keeping the UK at the forefront of medical innovation. potential for collaboration in having a colocated shared data centre. “The Crick has been proud to take a leading role in support of Janet.