CEHS Publications 2016

Adar S, Hu J, Lieb JD, Sancar A. Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 2016 Apr 12;113(15):E2124-33. PMCID: PMC4839430.

Adrion AC, Nakamura J, Shea D, Aitken MD. Screening Nonionic Surfactants for Enhanced Biodegradation of Polycyclic Aromatic Hydrocarbons Remaining in Soil After Conventional Biological Treatment. Environmental science & technology. 2016 Apr 05;50(7):3838-45. PMCID: PMC4973855.

Adrion AC, Singleton DR, Nakamura J, Shea D, Aitken MD. Improving Polycyclic Aromatic Hydrocarbon Biodegradation in Contaminated Soil Through Low-Level Surfactant Addition After Conventional Bioremediation. Environmental engineering science. 2016 Sep 01;33(9):659-70. PMCID: PMC5031096.

Allott EH, Cohen SM, Geradts J, Perou CM, Olshan AF, Troester MA, et al. Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2016 Mar;25(3):470-8. PMCID: PMC4779705.

Allott EH, Geradts J, Sun X, Cohen SM, Olshan AF, Troester MA, et al. Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification. Breast cancer research : BCR. 2016 Jun 28;18(1):68. PMCID: PMC4924300.

Angelon-Gaetz KA, Richardson DB, Marshall SW, Hernandez ML. Exploration of the effects of classroom humidity levels on teachers' respiratory symptoms. International archives of occupational and environmental health. 2016 Jul;89(5):729-37. PMCID: PMC4873430.

Au KM, Satterlee A, Min Y, Tian X, Kim YS, Wang AZ, et al. Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic. Biomaterials. 2016 Mar;82:178-93. PMCID: PMC4728024.

Bailey KA, Smith AH, Tokar EJ, Graziano JH, Kim KW, Fry RC, et al. Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps. Environ Health Perspect. 2016 Feb;124(2):170-5. PMCID: PMC4749078.

Bair E, Gaynor S, Slade GD, Ohrbach R, Fillingim RB, Maixner W, et al. Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study. Pain. 2016 Jun;157(6):1266-78. PMCID: PMC4949303.

Benamar M, Guessous F, Du K, Corbett P, Obeid J, Abbas T, et al. Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. EBioMedicine. 2016 Aug;10:85-100. PMCID: PMC5006603.

CEHS Publications 2016

Berchuck SI, Warren JL, Herring AH, Evenson KR, Moore KA, Ranchod YK, Diez-Roux . Spatially Modelling the Association Between Access to Recreational Facilities and Exercise: The 'Multi-Ethnic Study of Atherosclerosis'. J R Stat Soc Ser A Stat Soc. 2016 Jan;179(1):293-310. PMCID: PMC4751045.

Boffetta P, Hayes RB, Sartori S, Lee YC, Olshan A, Hashibe M, et al. Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2016 Jul;25(4):344-8. PMCID: PMC4752930.

Bradshaw PT, Stevens J, Khankari N, Teitelbaum SL, Neugut AI, Gammon MD. Cardiovascular Disease Mortality Among Breast Cancer Survivors. Epidemiology. 2016 Jan;27(1):6-13. PMCID: PMC4666721.

Brooks SA, Khandani AH, Fielding JR, Lin W, Parker JS, Rathmell WK, et al. Alternate Metabolic Programs Define Regional Variation of Relevant Biological Features in Renal Carcinoma Progression. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Jun 15;22(12):2950-9. PMCID: PMC4911278.

Buckley JP, Engel SM, Daniels JL, Richardson DB, Herring AH, Rundle AG, et al. Prenatal Phthalate Exposures and Body Mass Index Among 4- to 7-Year-old Children: A Pooled Analysis. Epidemiology. 2016 May;27(3):449-58. PMCID: PMC4821741.

Buckley JP, Engel SM, Mendez MA, Richardson DB, Daniels JL, Herring AH, et al. Prenatal Phthalate Exposures and Childhood Fat Mass in a New York City Cohort. Environ Health Perspect. 2016 Apr;124(4):507-13. PMCID: PMC4829985.

Buckley JP, Herring AH, Wolff MS, Calafat AM, Engel SM. Prenatal exposure to environmental phenols and childhood fat mass in the Mount Sinai Children's Environmental Health Study. Environ Int. 2016 May;91:350-6. PMCID: PMC4834980.

Busch EL, Keku TO, Richardson DB, Cohen SM, Eberhard DA, Avery CL, Sandler RS. Evaluating markers of epithelial-mesenchymal transition to identify cancer patients at risk for metastatic disease. Clinical & experimental metastasis. 2016 Jan;33(1):53-62. PMCID: PMC4742430.

Byrne JD, Jajja MR, Schorzman AN, Zamboni WC, DeSimone JM, Yeh JJ, et al. Iontophoretic device delivery for the localized treatment of pancreatic ductal adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. 2016 Feb 23;113(8):2200- 5. PMCID: PMC4776454.

Cheng TD, Ambrosone CB, Troester MA, Bensen JT, Olshan AF, Rosenberg L, et al. Genetic variants in the mTOR pathway and breast cancer risk in African American women. Carcinogenesis. 2016 Jan;37(1):49-55. PMCID: PMC5006112.

CEHS Publications 2016

Chollet-Hinton L, Anders CK, Tse CK, Bell MB, Yang YC, Carey LA, Olshan AF, Troester MA. Breast cancer biologic and etiologic heterogeneity by young age and menopausal status in the Carolina Breast Cancer Study: a case-control study. Breast cancer research : BCR. 2016 Aug 04;18(1):79. PMCID: PMC4972943.

Cooley B, Funkhouser W, Monroe D, Ezzell A, Mann DM, Lin FC, Monahan PE, Stafford DW. Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice. Blood. 2016 Jul 14;128(2):286-92. PMCID: PMC5291301.

Cordeiro-Stone M, McNulty JJ, Simpson DA, Thomas NE, Ibrahim JG, Kaufmann WK, et al. Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines. Pigment cell & melanoma research. 2016 Jan;29(1):68-80. PMCID: PMC4745347.

Dellon ES, Higgins LL, Beitia R, Rusin S, Parker JS, Grimm M, et al. Prospective assessment of serum periostin as a biomarker for diagnosis and monitoring of eosinophilic oesophagitis. Alimentary pharmacology & therapeutics. 2016 Jul;44(2):189-97. PMCID: PMC4907797.

Drobna Z, Martin E, Kim KS, Smeester L, Styblo M, Fry RC, et al. Analysis of maternal polymorphisms in arsenic (+3 oxidation state)- methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis. Reproductive toxicology (Elmsford, NY). 2016 Jun;61:28-38. PMCID: PMC4970429.

Duran CG, Burbank AJ, Mills KH, Peden DB, Zhou H, Hernandez ML, et al. A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation. Respiratory research. 2016 Jul 22;17(1):89. PMCID: PMC4957339.

Fannin RD, Gerrish K, Sieber SO, Bushel PR, Watkins PB, Paules RS. Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clinical pharmacology and therapeutics. 2016 Apr;99(4):432-41. PMCID: PMC4785037.

Filgo AJ, Foley JF, Puvanesarajah S, Borde AR, Troester MA, Fenton SE, et al. Mammary Gland Evaluation in Juvenile Toxicity Studies: Temporal Developmental Patterns in the Male and Female Harlan Sprague-Dawley Rat. Toxicologic pathology. 2016 Oct;44(7):1034-58. PMCID: PMC5068132.

Gao Y, Mutter-Rottmayer E, Greenwalt AM, Goldfarb D, Yan F, Vaziri C, et al. A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis. Nature communications. 2016 Jul 05;7:12105. PMCID: PMC4935975.

Gibbs DC, Orlow I, Bramson JI, Kanetsky PA, Luo L, Thomas NE, Group GEMS, et al. Association of Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways. Journal of the National Cancer Institute. 2016 Jul;108(7). PMCID: PMC4948568.

CEHS Publications 2016

Gmeiner WH, Gearhart PJ, Pommier Y, Nakamura J. F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death. Future oncology (London, England). 2016 Oct;12(19):2183-8. PMCID: PMC5551924.

Graff M, Richardson AS, Young KL, Mazul AL, North KE, Gordon-Larsen P, et al. The interaction between physical activity and obesity variants in association with BMI: Does the obesogenic environment matter? Health & place. 2016 Nov;42:159-65. PMCID: PMC5116401.

Gutierrez T, Berry D, Teske A, Aitken MD. Enrichment of Fusobacteria in Sea Surface Oil Slicks from the Deepwater Horizon Oil Spill. Microorganisms. 2016 Jul 27;4(3). PMCID: PMC5039584.

Haake SM, Brooks SA, Welsh E, Fulp WJ, Chen DT, Fishman M, et al. Patients with ClearCode34-identified molecular subtypes of clear cell renal cell carcinoma represent unique populations with distinct comorbidities. Urol Oncol. 2016 Mar;34(3):122 e1-7. PMCID: PMC4761468.

Haddad SA, Ruiz-Narvaez EA, Haiman CA, Bensen JT, Olshan AF, Lunetta KL, et al. An exome-wide analysis of low frequency and rare variants in relation to risk of breast cancer in African American Women: the AMBER Consortium. Carcinogenesis. 2016 Sep;37(9):870-7. PMCID: PMC5008246.

Hampel D, Shahab-Ferdows S, Adair LS, Bentley ME, Flax VL, Allen LH, et al. Thiamin and Riboflavin in Human Milk: Effects of Lipid-Based Nutrient Supplementation and Stage of Lactation on Vitamer Secretion and Contributions to Total Vitamin Content. PloS one. 2016;11(2):e0149479. PMCID: PMC4757446.

Hashimoto K, Sharma V, Sasanuma H, Tian X, Swenberg JA, Nakamura J, et al. Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells. Oncotarget. 2016 Sep 13;7(37):59795-808. PMCID: PMC5312349.

High M, Cho HY, Marzec J, Wiltshire T, Peden DB, Kleeberger SR, et al. Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants. EBioMedicine. 2016 Sep;11:73-84. PMCID: PMC5049919.

Hirsch JA, Meyer KA, Peterson M, Rodriguez DA, Song Y, Peng K, Huh J, Gordon-Larsen P. Obtaining Longitudinal Built Environment Data Retrospectively across 25 years in Four US Cities. Frontiers in public health. 2016;4:65. PMCID: PMC4835448.

Hoffman K, Lorenzo A, Butt CM, Adair L, Herring AH, Stapleton HM, Daniels JL. Predictors of urinary flame retardant concentration among pregnant women. Environ Int. 2017 Jan;98:96-101. PMCID: PMC5127734.

CEHS Publications 2016

Hoopes J, Cortez L, Mertz T, Malc EP, Mieczkowski PA, Roberts SA. APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication. Cell reports. 2016 Feb 16;14(6):1273-82. PMCID: PMC4758883.

Hu J, Lieb JD, Sancar A, Adar S. Cisplatin DNA damage and repair maps of the at single-nucleotide resolution. Proceedings of the National Academy of Sciences of the United States of America. 2016 Oct 11;113(41):11507-12. PMCID: PMC5068337.

Hu P, Li Y, Nikolaishvili-Feinberg N, Scesa G, Bi Y, Pan D, Kafri T, et al. Hematopoietic Stem cell transplantation and lentiviral vector-based gene therapy for Krabbe's disease: Present convictions and future prospects. Journal of neuroscience research. 2016 Nov;94(11):1152-68. PMCID: PMC5027985.

Huang MC, Douillet C, Su M, Zhou K, Fry RC, Styblo M, et al. Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Archives of toxicology. 2017 Jan;91(1):189-202. PMCID: PMC4987274.

Huo D, Feng Y, Haddad S, Bensen JT, Olshan AF, Haiman CA. et al. Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Human molecular genetics. 2016 Nov 01;25(21):4835-46. PMCID: Method A.

Johnson AR, Qin Y, Cozzo AJ, Freemerman AJ, Beck MA, Makowski L, et al. Metabolic reprogramming through fatty acid transport 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Molecular metabolism. 2016 Jul;5(7):506-26. PMCID: PMC4921943.

Johnson AR, Wilkerson MD, Sampey BP, Troester MA, Hayes DN, Makowski L. Cafeteria diet-induced obesity causes oxidative damage in white adipose. Biochemical and biophysical research communications. 2016 Apr 29;473(2):545-50. PMCID: PMC4862365.

Johnston JE, Hoffman K, Wing S, Lowman A. Fish Consumption Patterns and Mercury Advisory Knowledge Among Fishers in the Haw River Basin. North Carolina medical journal. 2016 Jan-Feb;77(1):9-14. PMCID: PMC4762258.

Karumuthil-Melethil S, Marshall MS, Heindel C, Jakubauskas B, Bongarzone ER, Gray SJ. Intrathecal administration of AAV/GALC vectors in 10- 11-day-old twitcher mice improves survival and is enhanced by bone marrow transplant. Journal of neuroscience research. 2016 Nov;94(11):1138- 51. PMCID: PMC5028109.

Karumuthil-Melethil S, Nagabhushan Kalburgi S, Thompson P, Tropak M, Kaytor MD, Gray SJ, et al. Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease. Human gene therapy. 2016 Jul;27(7):509- 21. PMCID: PMC5349231.

CEHS Publications 2016

Kobernick AK, Peden DB, Zhou H, Zhou Q, Dillon MA, Alexis NE. Reproducibility of the inflammatory response to inhaled endotoxin in healthy volunteers. The Journal of allergy and clinical immunology. 2016 Oct;138(4):1205-7. PMCID: PMC5056796.

Korfmacher KS, Pettibone KG, Gray KM, Newman OD. Collaborating for Systems Change: A Social Science Framework for Academic Roles in Community Partnerships. New solutions: a journal of environmental and occupational health policy : NS. 2016 Aug 17. PMCID: PMC5315683.

Lai Y, Yu R, Hartwell HJ, Moeller BC, Bodnar WM, Swenberg JA. Measurement of Endogenous versus Exogenous Formaldehyde-Induced DNA- Protein Crosslinks in Tissues by Stable Isotope Labeling and Ultrasensitive Mass Spectrometry. Cancer research. 2016 May 01;76(9):2652-61. PMCID: PMC4879886.

Lang PY, Nanjangud GJ, Sokolsky-Papkov M, Shaw C, Hwang D, Parker JS, Kabanov AV, Gershon TR. ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation. Development (Cambridge, England). 2016 Nov 01;143(21):4038-52. PMCID: PMC5117143.

Lesseur C, Diergaarde B, Olshan AF, Wunsch-Filho V, Ness AR, Brennan P, et al. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. Nature genetics. 2016 Dec;48(12):1544-50. PMCID: PMC5131845.

Lipner MB, Marayati R, Deng Y, Wang X, Raftery L, O'Neil BH, Yeh JJ. Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts. PloS one. 2016;11(1):e0147113. PMCID: PMC4711922.

Losina E, Michl G, Collins JE, Hunter DJ, Jordan JM, Yelin E, Paltiel AD, Katz JN. Model-based evaluation of cost-effectiveness of nerve growth factor inhibitors in knee osteoarthritis: impact of drug cost, toxicity, and means of administration. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2016 May;24(5):776-85. PMCID: PMC4838505.

Mazul AL, Siega-Riz AM, Weinberg CR, Engel SM, Basta PV, Olshan AF, et al. A family-based study of gene variants and maternal folate and choline in neuroblastoma: a report from the Children's Oncology Group. Cancer causes & control : CCC. 2016 Oct;27(10):1209-18. PMCID: PMC5025391.

McCullough LE, Chen J, Cho YH, Khankari NK, Bradshaw PT, Gammon MD, et al. DNA methylation modifies the association between obesity and survival after breast cancer diagnosis. Breast cancer research and treatment. 2016 Feb;156(1):183-94. PMCID: PMC4890602.

McEachran AD, Shea D, Bodnar W, Nichols EG. Pharmaceutical occurrence in groundwater and surface waters in forests land-applied with municipal wastewater. Environ Toxicol Chem. 2016 Apr;35(4):898-905. PMCID: PMC4976290.

CEHS Publications 2016

McKee MJ, Keith K, Deal AM, Garrett AL, Wheless AA, Zagar TM, et al. A Multidisciplinary Breast Cancer Brain Metastases Clinic: The University of North Carolina Experience. The oncologist. 2016 Jan;21(1):16-20. PMCID: PMC4709216.

Mendez MA, Gonzalez-Horta C, Sanchez-Ramirez B, Ballinas-Casarrubias L, Fry RC, Styblo M, et al. Chronic Exposure to Arsenic and Markers of Cardiometabolic Risk: A Cross-Sectional Study in Chihuahua, Mexico. Environ Health Perspect. 2016 Jan;124(1):104-11. PMCID: PMC4710594.

Montgomery ND, Liomba NG, Kampani C, Krysiak R, Stanley CC, Fedoriw Y, et al. Accurate Real-Time Diagnosis of Lymphoproliferative Disorders in Malawi Through Clinicopathologic Teleconferences: A Model for Pathology Services in Sub-Saharan Africa. American journal of clinical pathology. 2016 Oct;146(4):423-30. PMCID: PMC5040876.

Mordukhovich I, Beyea J, Herring AH, Richardson DB, Millikan RC, Engel LS, Gammon MD, et al. Vehicular Traffic-Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP). Environ Health Perspect. 2016 Jan;124(1):30-8. PMCID: PMC4710589.

Muller L, Meyer M, Bauer RN, Zhou H, Zhang H, Noah TL, Jaspers I, et al. Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study. PloS one. 2016;11(1):e0147742. PMCID: PMC4731143.

Murlidharan G, Crowther A, Reardon RA, Song J, Asokan A. Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain. JCI insight. 2016 Sep 08;1(14):e88034. PMCID: PMC5033923.

Murphy LB, Moss S, Do BT, Helmick CG, Schwartz TA, Jordan JM, et al. Annual Incidence of Knee Symptoms and Four Knee Osteoarthritis Outcomes in the Johnston County Osteoarthritis Project. Arthritis care & research. 2016 Jan;68(1):55-65. PMCID: PMC4684807.

Mutlu E, Gao L, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Swenberg JA, et al. Polychlorinated Biphenyls Induce Oxidative DNA Adducts in Female Sprague-Dawley Rats. Chemical research in toxicology. 2016 Aug 15;29(8):1335-44. PMCID: PMC5020703.

Nakamura A, Swahari V, Plestant C, Smith I, McCoy E, Deshmukh M, et al. Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 May 18;36(20):5448-61. PMCID: PMC4871982.

Napier MD, Poole C, Satten GA, Ashley-Koch A, Marrie RA, Williamson DM. Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions. Archives of environmental & occupational health. 2016;71(1):26-34. PMCID: PMC4334728.

CEHS Publications 2016

Okolie O, Bago JR, Schmid RS, Irvin DM, Bash RE, Miller CR, Hingtgen SD. Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model. Neuro Oncol. 2016 Dec;18(12):1622-33. PMCID: Method A.

Olesen R, Swanson MD, Kovarova M, Nochi T, Chateau M, Garcia JV, et al. ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions. The Journal of clinical investigation. 2016 Mar 01;126(3):892-904. PMCID: PMC4767352.

Pascual F, Coleman RA. Fuel availability and fate in cardiac metabolism: A tale of two substrates. Biochimica et biophysica acta. 2016 Oct;1861(10):1425-33. PMCID: PMC4983230.

Pawlak EA, Noah TL, Zhou H, Chehrazi C, Robinette C, Jaspers I, et al. Diesel exposure suppresses natural killer cell function and resolution of eosinophil inflammation: a randomized controlled trial of exposure in allergic rhinitics. Particle and fibre toxicology. 2016 May 06;13(1):24. PMCID: PMC4859992.

Petrick JL, Freedman ND, Demuth J, Yang B, Engel LS, McGlynn KA, et al. Obesity, diabetes, serum glucose, and risk of primary liver cancer by birth cohort, race/ethnicity, and sex: Multiphasic health checkup study. Cancer epidemiology. 2016 Jun;42:140-6. PMCID: PMC4899157.

Pitman CL, Brereton KR, Miller AJ. Aqueous Hydricity of Late Metal Catalysts as a Continuum Tuned by Ligands and the Medium. Journal of the American Chemical Society. 2016 Feb 24;138(7):2252-60. PMCID: PMC4768292.

Qin Y, Sundaram S, Essaid L, Chen X, Troester MA, Makowski L, et al. Weight loss reduces basal-like breast cancer through kinome reprogramming. Cancer cell international. 2016;16:26. PMCID: PMC4818517.

Randell RL, Gulati AS, Basta PV, Luo J, Sandler RS, Kappelman MD, et al. Collecting Biospecimens From an Internet-Based Prospective Cohort Study of Inflammatory Bowel Disease (CCFA Partners): A Feasibility Study. JMIR research protocols. 2016 Jan 05;5(1):e3. PMCID: PMC4719077.

Rappazzo KM, Warren JL, Meyer RE, Herring AH, Sanders AP, Brownstein NC, Luben TJ. Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort. Birth Defects Res A Clin Mol Teratol. 2016 Apr;106(4):240-9. PMCID: PMC4833532.

Rigby RJ, Carr J, Orgel K, King SL, Lund PK, Dekaney CM. Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis. Gut microbes. 2016 Sep 02;7(5):414-23. PMCID: PMC5046166.

CEHS Publications 2016

Roberts MC, Weinberger M, Dusetzina SB, Dinan MA, Troester MA, Wheeler SB, et al. Racial Variation in the Uptake of Oncotype DX Testing for Early-Stage Breast Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Jan 10;34(2):130-8. PMCID: PMC4872005.

Romero NE, Matson SW, Sekelsky J. Biochemical Activities and Genetic Functions of the Drosophila melanogaster Fancm Helicase in DNA Repair. Genetics. 2016 Oct;204(2):531-41. PMCID: PMC5068844.

Roque DR, Makowski L, Chen TH, Rashid N, Hayes DN, Bae-Jump V. Association between differential and body mass index among endometrial cancers from The Cancer Genome Atlas Project. Gynecologic oncology. 2016 Aug;142(2):317-22. PMCID: PMC4961559.

Ruiz-Narvaez EA, Haddad SA, Lunetta KL, Bensen JT, Olshan AF, Palmer JR, et al. Gene-based analysis of the fibroblast growth factor receptor signaling pathway in relation to breast cancer in African American women: the AMBER consortium. Breast cancer research and treatment. 2016 Jan;155(2):355-63. PMCID: PMC4890604.

Ruiz-Narvaez EA, Sucheston-Campbell L, Bensen JT, Olshan AF, Lunetta KL, et al. Admixture Mapping of African-American Women in the AMBER Consortium Identifies New Loci for Breast Cancer and Estrogen-Receptor Subtypes. Frontiers in genetics. 2016;7:170. PMCID: PMC5030764.

Rummo PE, Hirsch JA, Howard AG, Gordon-Larsen P. In which neighborhoods are older adult populations expanding?: Sociodemographic and built environment characteristics across neighborhood trajectory classes of older adult populations in four U.S. cities over 30 Years. Gerontology & geriatric medicine. 2016 Jan-Dec;2. PMCID: PMC5072399.

Saini N, Roberts SA, Boyer JC, Kaufmann WK, Mieczkowski PA, Gordenin DA, et al. The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts. PLoS genetics. 2016 Oct;12(10):e1006385. PMCID: PMC5082821.

Sandhu R, Chollet-Hinton L, Kirk EL, Midkiff B, Troester MA. Digital histologic analysis reveals morphometric patterns of age-related involution in breast epithelium and stroma. Human pathology. 2016 Feb;48:60-8. PMCID: PMC4727830.

Satterlee AB, Rojas JD, Dayton PA, Huang L. Enhancing Nanoparticle Accumulation and Retention in Desmoplastic Tumors via Vascular Disruption for Internal Radiation Therapy. Theranostics. 2017;7(2):253-69. PMCID: PMC5197062.

Schmid RS, Simon JM, Vitucci M, McNeill RS, Bash RE, Miller CR, et al. Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide. Neuro Oncol. 2016 Jul;18(7):962-73. PMCID: PMC4896545.

CEHS Publications 2016

Seifert BA, O'Daniel JM, Amin K, Parker JS, Sharpless NE, Berg JS, et al. Germline Analysis from Tumor-Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Aug 15;22(16):4087-94. PMCID: PMC4987173.

Sharma V, Collins LB, Chen TH, Herr N, Swenberg JA, Nakamura J, et al. Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations. Oncotarget. 2016 May 03;7(18):25377-90. PMCID: PMC5041911.

Smith GS, Van Den Eeden SK, Garcia C, Herring AH, Richardson DB, Gammon MD, et al. Air Pollution and Pulmonary Tuberculosis: A Nested Case-Control Study among Members of a Northern California Health Plan. Environ Health Perspect. 2016 Jun;124(6):761-8. PMCID: PMC4892908.

Souroullas GP, Jeck WR, Parker JS, Simon JM, Liu JY, Sharpless NE, et al. An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 27 trimethylation. Nature medicine. 2016 Jun;22(6):632-40. PMCID: PMC4899144.

Stern D, Poti JM, Ng SW, Robinson WR, Gordon-Larsen P, Popkin BM. Where people shop is not associated with the nutrient quality of packaged foods for any racial-ethnic group in the United States. The American journal of clinical nutrition. 2016 Apr;103(4):1125-34. PMCID: PMC4807703.

Stine JE, Guo H, Sheng X, Han X, Schointuch MN, Bae-Jump VL, et al. The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer. Oncotarget. 2016 Jan 05;7(1):946-60. PMCID: PMC4808044.

Suen AA, Jefferson WN, Wood CE, Padilla-Banks E, Bae-Jump VL, Williams CJ. SIX1 Oncoprotein as a Biomarker in a Model of Hormonal Carcinogenesis and in Human Endometrial Cancer. Molecular cancer research : MCR. 2016 Sep;14(9):849-58. PMCID: PMC5025359.

Sun W, Kechris K, Jacobson S, Drummond MB, Basta PV, Bowler RP, Group SR, Investigators CO, et al. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS genetics. 2016 Aug;12(8):e1006011. PMCID: PMC4988780.

Swahari V, Nakamura A, Baran-Gale J, Garcia I, Crowther AJ, Deshmukh M, et al. Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum. Cell reports. 2016 Jan 12;14(2):216-24. PMCID: PMC4716786.

Tan Z, Qin G, Zhou H. Estimation of a partially linear additive model for data from an outcome-dependent sampling design with a continuous outcome. Biostatistics (Oxford, England). 2016 Oct;17(4):663-76. PMCID: PMC5031945.

CEHS Publications 2016

Taylor NJ, Nikolaishvili-Feinberg N, Midkiff BR, Conway K, Millikan RC, Geradts J. Rational Manual and Automated Scoring Thresholds for the Immunohistochemical Detection of TP53 Missense Mutations in Human Breast Carcinomas. Applied immunohistochemistry & molecular morphology : AIMM. 2016 Jul;24(6):398-404. PMCID: PMC4716889.

Taylor NJ, Thomas NE, Anton-Culver H, Armstrong BK, Begg CB, Kanetsky PA, Group GEMS, et al. Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma. International journal of cancer. 2016 Sep 15;139(6):1217-22. PMCID: PMC4939099.

Tian X, Patel K, Ridpath JR, Chen Y, Swenberg JA, Nakamura J, et al. Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium. PloS one. 2016;11(12):e0167503. PMCID: PMC5132242.

Tinling MA, West JJ, Cascio WE, Kilaru V, Rappold AG. Repeating cardiopulmonary health effects in rural North Carolina population during a second large peat wildfire. Environmental health : a global access science source. 2016 Jan 27;15:12. PMCID: PMC4728755.

Vance TM, Wang Y, Su LJ, Fontham ET, Bensen JT, Chun OK, et al. Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study. Nutrition and cancer. 2016;68(2):214-24. PMCID: PMC4821782.

Vizuete W, Sexton KG, Nguyen H, Smeester L, Aagaard KM, Fry RC, et al. From the Field to the Laboratory: Air Pollutant-Induced Genomic Effects in Lung Cells. Environmental health insights. 2016 Feb 18;9(Suppl 4):15-23. PMCID: PMC4760675.

Wang Y, Surzenko N, Friday WB, Zeisel SH. Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Apr;30(4):1566-78. PMCID: PMC4799499.

Warren JL, Mwanza JC, Tanna AP, Budenz DL. A Statistical Model to Analyze Clinician Expert Consensus on Glaucoma Progression using Spatially Correlated Visual Field Data. Translational vision science & technology. 2016 Aug;5(4):14. PMCID: PMC5017314.

Warren JL, Perez-Heydrich C, Burgert CR, Emch ME. Influence of Demographic and Health Survey Point Displacements on Distance-Based Analyses. Spat Demogr. 2016 Jul;4(2):155-73. PMCID: PMC4946438.

Warren JL, Perez-Heydrich C, Burgert CR, Emch ME. Influence of Demographic and Health Survey Point Displacements on Point-in-Polygon Analyses. Spat Demogr. 2016 Jul;4(2):117-33. PMCID: PMC4950678.

CEHS Publications 2016

Wen W, Kato N, Hwang JY, Guo X, Tabara Y, Shu XO, et al. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Scientific reports. 2016 Jan 20;6:17958. PMCID: PMC4726286.

White AJ, Bradshaw PT, Herring AH, Teitelbaum SL, Engel LS, Gammon MD, et al. Exposure to multiple sources of polycyclic aromatic hydrocarbons and breast cancer incidence. Environ Int. 2016 Apr-May;89-90:185-92. PMCID: PMC4818720.

White AJ, Chen J, Teitelbaum SL, McCullough LE, Engel LS, Gammon MD, et al. Sources of polycyclic aromatic hydrocarbons are associated with gene-specific promoter methylation in women with breast cancer. Environ Res. 2016 Feb;145:93-100. PMCID: PMC4706465.

Williams LA, Olshan AF, Tse CK, Bell ME, Troester MA. Alcohol intake and invasive breast cancer risk by molecular subtype and race in the Carolina Breast Cancer Study. Cancer causes & control : CCC. 2016 Feb;27(2):259-69. PMCID: PMC5074055.

Wu TP, Wang T, Seetin MG, Lai Y, Swenberg JA, Xiao AZ, et al. DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature. 2016 Apr 21;532(7599):329-33. PMCID: PMC4977844.

Yang Y, Poe JC, Yang L, Fedoriw A, Desai S, Vaziri C, et al. Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. Nucleic acids research. 2016 May 19;44(9):4174-88. PMCID: PMC4872084.

Yao S, Haddad SA, Hu Q, Bensen JT, Olshan AF, Ambrosone CB, et al. Genetic variations in vitamin D-related pathways and breast cancer risk in African American women in the AMBER consortium. International journal of cancer. 2016 May 01;138(9):2118-26. PMCID: PMC5087916.

Young KL, Graff M, North KE, Richardson AS, Bradfield JP, Gordon-Larsen P, et al. Influence of SNP*SNP interaction on BMI in European American adolescents: findings from the National Longitudinal Study of Adolescent Health. Pediatric obesity. 2016 Apr;11(2):95-101. PMCID: PMC4615264.

Yuan L, Sheng X, Clark LH, Zhang L, Guo H, Bae-Jump VL, et al. inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer. American journal of translational research. 2016 Oct 15;8(10):4265-77. PMCID: PMC5095319.

Zavala J, O'Brien B, Lichtveld K, Sexton KG, Rusyn I, Jaspers I, Vizuete W. Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution. Inhalation toxicology. 2016;28(6):251-9. PMCID: PMC4913276.

CEHS Publications 2016

Zhang J, Yao S, Bensen JT, Troester MA, Olshan AF, Ambrosone CB, et al. Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium. Carcinogenesis. 2016 Oct;37(10):951-6. PMCID: PMC5035397.

Zhu Q, Shepherd L, Lunetta KL, Yao S, Bensen JT, Olshan AF, Ambrosone CB, et al. Trans-ethnic follow-up of breast cancer GWAS hits using the preferential linkage disequilibrium approach. Oncotarget. 2016 Dec 13;7(50):83160-76. PMCID: PMC5341253.

Zwart SR, Gregory JF, Zeisel SH, Gibson CR, Mader TH, Smith SM, et al. Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Jan;30(1):141-8. PMCID: PMC4684521.