Supplementary 1: YBX1 and its Interactors derived from UniHi, Metamatched and TRRUST databases.

Gene_Id Description ABCB1|5243 ATP binding cassette subfamily B member 1 ACTB|60 actin beta AFF4|27125 AF4/FMR2 family member 4 AGT|183 angiotensinogen AKT1|207 AKT serine/threonine kinase 1 AMOTL1|154810 angiomotin like 1 ANAPC4|29945 anaphase promoting complex subunit 4 ANKRD2|26287 ankyrin repeat domain 2 APBB1|322 amyloid beta precursor binding family B member 1 APEX1|328 apurinic/apyrimidinic endodeoxyribonuclease 1 AR|367 ARID1A|8289 AT-rich interaction domain 1A ARRB1|408 arrestin beta 1 ARRB2|409 arrestin beta 2 ATF1|466 activating 1 ATF2|1386 activating transcription factor 2 ATP6V1E1|529 ATPase H+ transporting V1 subunit E1 BARD1|580 BRCA1 associated RING domain 1 BCL6|604 B-cell CLL/lymphoma 6 BRCA1|672 BRCA1, DNA repair associated C19orf2|8725 URI1, prefoldin like chaperone C1QBP|708 complement C1q binding protein carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and CAD|790 dihydroorotase CALM1|801 calmodulin 1 CAND1|55832 cullin associated and neddylation dissociated 1 CBX8|57332 chromobox 8 CCAR1|55749 cell division cycle and apoptosis regulator 1 CCDC40|55036 coiled-coil domain containing 40 CCNB1|891 cyclin B1 CCNC|892 cyclin C CD2BP2|10421 CD2 cytoplasmic tail binding protein 2 CDC20|991 cell division cycle 20 CDH1|999 cadherin 1 CDK9|1025 cyclin dependent kinase 9 CDKN3|1033 cyclin dependent kinase inhibitor 3 CHD1|1105 chromodomain helicase DNA binding protein 1 CHTF18|63922 transmission fidelity factor 18 CKS2|1164 CDC28 protein kinase regulatory subunit 2 CLP1|10978 cleavage and factor I subunit 1 CMYA5|202333 cardiomyopathy associated 5 COBRA1|25920 negative elongation factor complex member B COPS5|10987 COP9 signalosome subunit 5 CPSF1|29894 cleavage and polyadenylation specific factor 1 CPSF2|53981 cleavage and polyadenylation specific factor 2 CPSF3|51692 cleavage and polyadenylation specific factor 3 CPSF6|11052 cleavage and polyadenylation specific factor 6 CPSF7|79869 cleavage and polyadenylation specific factor 7 CREB1|1385 cAMP responsive element binding protein 1 CSAD|51380 cysteine sulfinic acid decarboxylase CSDA|8531 Y-box binding protein 3 CSNK2A1|1457 casein kinase 2 alpha 1 CSTF1|1477 cleavage stimulation factor subunit 1 CSTF2|1478 cleavage stimulation factor subunit 2 CSTF3|1479 cleavage stimulation factor subunit 3 CTCF|10664 CCCTC-binding factor CUL1|8454 cullin 1 CUL2|8453 cullin 2 CUL3|8452 cullin 3 CUL4B|8450 cullin 4B CXCR4|7852 C-X-C motif chemokine receptor 4 DDX1|1653 DEAD-box helicase 1 DDX23|9416 DEAD-box helicase 23 DDX3X|1654 DEAD-box helicase 3, X-linked DHX30|22907 DExH-box helicase 30 DHX38|9785 DEAH-box helicase 38 DHX9|1660 DExH-box helicase 9 DIAPH1|1729 diaphanous related formin 1 DIMT1L|27292 DIM1 dimethyladenosine transferase 1 homolog DMXL1|1657 Dmx like 1 DNAJC8|22826 DnaJ heat shock protein family (Hsp40) member C8 DNMT1|1786 DNA methyltransferase 1 DYNC1H1|1778 dynein cytoplasmic 1 heavy chain 1 DYNC1I2|1781 dynein cytoplasmic 1 intermediate chain 2 DYNC1LI2|1783 dynein cytoplasmic 1 light intermediate chain 2 |1869 transcription factor 1 EEF1A1|1915 eukaryotic translation elongation factor 1 alpha 1 EFTUD2|9343 elongation factor Tu GTP binding domain containing 2 EGFR|1956 epidermal growth factor receptor EGR1|1958 early growth response 1 EIF2B2|8892 eukaryotic translation initiation factor 2B subunit beta EIF2C1|26523 argonaute 1, RISC catalytic component EIF2C4|192670 argonaute 4, RISC catalytic component EIF2S1|1965 eukaryotic translation initiation factor 2 subunit alpha EIF3K|27335 eukaryotic translation initiation factor 3 subunit K EIF4A3|9775 eukaryotic translation initiation factor 4A3 ELK1|2002 ELK1, ETS transcription factor EP300|2033 E1A binding protein p300 EPRS|2058 glutamyl-prolyl-tRNA synthetase ERBB2|2064 erb-b2 receptor tyrosine kinase 2 ERBB3|2065 erb-b2 receptor tyrosine kinase 3 ESR1|2099 1 ETS1|2113 ETS proto-oncogene 1, transcription factor ETV4|2118 ETS variant 4 EWSR1|2130 EWS RNA binding protein 1 EZH2|2146 enhancer of zeste 2 polycomb repressive complex 2 subunit FAS|355 Fas cell surface death receptor FBXO33|254170 F-box protein 33 FKBP3|2287 FK506 binding protein 3 FLOT1|10211 flotillin 1 FMR1|2332 fragile X mental retardation 1 FN1|2335 fibronectin 1 FOXM1|2305 forkhead box M1 FUS|2521 FUS RNA binding protein G3BP1|10146 G3BP stress granule assembly factor 1 GATA3|2625 GATA binding protein 3 GATA4|2626 GATA binding protein 4 GIGYF2|26058 GRB10 interacting GYF protein 2 GIPC1|10755 GIPC PDZ domain containing family member 1 GRINL1A|81488 RNA polymerase II subunit M GSK3B|2932 glycogen synthase kinase 3 beta GTF2F1|2962 general transcription factor IIF subunit 1 GTF2F2|2963 general transcription factor IIF subunit 2 GZF1|64412 GDNF inducible protein 1 HABP4|22927 hyaluronan binding protein 4 HDAC1|3065 histone deacetylase 1 HDAC2|3066 HDAC3|8841 histone deacetylase 3 HDGF|3068 heparin binding growth factor HIF1A|3091 hypoxia inducible factor 1 alpha subunit HIST1H1C|3006 histone cluster 1 H1 family member c HLA-C|3107 major histocompatibility complex, class I, C HNF4A|3172 hepatocyte nuclear factor 4 alpha HNRNPA0|10949 heterogeneous nuclear ribonucleoprotein A0 HNRNPA1|3178 heterogeneous nuclear ribonucleoprotein A1 HNRNPA2B1|318 1 heterogeneous nuclear ribonucleoprotein A2/B1 HNRNPA3|220988 heterogeneous nuclear ribonucleoprotein A3 HNRNPAB|3182 heterogeneous nuclear ribonucleoprotein A/B HNRNPC|3183 heterogeneous nuclear ribonucleoprotein C (C1/C2) HNRNPD|3184 heterogeneous nuclear ribonucleoprotein D HNRNPF|3185 heterogeneous nuclear ribonucleoprotein F HNRNPH1|3187 heterogeneous nuclear ribonucleoprotein H1 HNRNPH2|3188 heterogeneous nuclear ribonucleoprotein H2 HNRNPK|3190 heterogeneous nuclear ribonucleoprotein K HNRNPL|3191 heterogeneous nuclear ribonucleoprotein L HNRNPM|4670 heterogeneous nuclear ribonucleoprotein M HNRNPR|10236 heterogeneous nuclear ribonucleoprotein R HNRNPU|3192 heterogeneous nuclear ribonucleoprotein U HNRNPUL1|1110 0 heterogeneous nuclear ribonucleoprotein U like 1 HOXB7|3217 B7 HSPA1A|3303 heat shock protein family A (Hsp70) member 1A HSPA2|3306 heat shock protein family A (Hsp70) member 2 HSPA5|3309 heat shock protein family A (Hsp70) member 5 IFIT1|3434 interferon induced protein with tetratricopeptide repeats 1 IFIT2|3433 interferon induced protein with tetratricopeptide repeats 2 IFIT3|3437 interferon induced protein with tetratricopeptide repeats 3 IL7R|3575 interleukin 7 receptor ILF2|3608 interleukin enhancer binding factor 2 IQCB1|9657 IQ motif containing B1 IREB2|3658 iron responsive element binding protein 2 IRF1|3659 interferon regulatory factor 1 IRS1|3667 insulin receptor substrate 1 ITGA4|3676 integrin subunit alpha 4 JAM2|58494 junctional adhesion molecule 2 JUN|3725 Jun proto-oncogene, AP-1 transcription factor subunit KHDRBS2|202559 KH RNA binding domain containing, signal transduction associated 2 KIAA0101|9768 PCNA clamp associated factor KLF4|9314 Kruppel like factor 4 KLF5|688 Kruppel like factor 5 KPNA2|3838 karyopherin subunit alpha 2 LARP1|23367 La ribonucleoprotein domain family member 1 LCP2|3937 lymphocyte cytosolic protein 2 LMAN1|3998 lectin, mannose binding 1 LSM2 homolog, U6 small nuclear RNA and mRNA degradation LSM2|57819 associated LSM3 homolog, U6 small nuclear RNA and mRNA degradation LSM3|27258 associated MAGOH|4116 mago homolog, junction complex core component MAP2|4133 microtubule associated protein 2 MAP3K14|9020 mitogen-activated protein kinase kinase kinase 14 MAPK1|5594 mitogen-activated protein kinase 1 MAPK13|5603 mitogen-activated protein kinase 13 MCCC2|64087 methylcrotonoyl-CoA carboxylase 2 MECP2|4204 methyl-CpG binding protein 2 MED6|10001 mediator complex subunit 6 MEPCE|56257 methylphosphate capping enzyme MET|4233 MET proto-oncogene, receptor tyrosine kinase METAP2|10988 methionyl aminopeptidase 2 MMP13|4322 matrix metallopeptidase 13 MMP2|4313 matrix metallopeptidase 2 MNAT1|4331 MNAT1, CDK activating kinase assembly factor MTA1|9112 metastasis associated 1 MVP|9961 major vault protein |4609 MYC proto-oncogene, bHLH transcription factor MYCN|4613 MYCN proto-oncogene, bHLH transcription factor NAP1L1|4673 nucleosome assembly protein 1 like 1 NAT10|55226 N-acetyltransferase 10 NCBP1|4686 nuclear cap binding protein subunit 1 NCBP2|22916 nuclear cap binding protein subunit 2 NCOR2|9612 corepressor 2 neural precursor cell expressed, developmentally down-regulated 4, E3 NEDD4|4734 ubiquitin protein ligase NEDD8|4738 neural precursor cell expressed, developmentally down-regulated 8 NFKB1|4790 nuclear factor kappa B subunit 1 NFX1|4799 nuclear transcription factor, X-box binding 1 NFYA|4800 nuclear transcription factor Y subunit alpha NFYB|4801 nuclear transcription factor Y subunit beta NFYC|4802 nuclear transcription factor Y subunit gamma NHP2L1|4809 SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) NMT1|4836 N-myristoyltransferase 1 NOP56|10528 NOP56 ribonucleoprotein NOS2|4843 nitric oxide synthase 2 NPM1|4869 nucleophosmin NR4A1|3164 nuclear receptor subfamily 4 group A member 1 NUDT21|11051 nudix hydrolase 21 PA2G4|5036 proliferation-associated 2G4 PABPN1|8106 poly(A) binding protein nuclear 1 PAN2|9924 PAN2 poly(A) specific ribonuclease subunit PAPOLA|10914 poly(A) polymerase alpha PARP1|142 poly(ADP-ribose) polymerase 1 PAX3|5077 paired box 3 PAX5|5079 paired box 5 PAX6|5080 paired box 6 PAXIP1|22976 PAX interacting protein 1 PCBP1|5093 poly(rC) binding protein 1 PCBP2|5094 poly(rC) binding protein 2 PCF11|51585 PCF11 cleavage and polyadenylation factor subunit PCNA|5111 proliferating cell nuclear antigen PCNT|5116 pericentrin PDCD7|10081 programmed cell death 7 PGR|5241 PHF5A|84844 PHD finger protein 5A PITX2|5308 paired like homeodomain 2 PIWIL1|9271 piwi like RNA-mediated silencing 1 PIWIL4|143689 piwi like RNA-mediated gene silencing 4 POLR2A|5430 RNA polymerase II subunit A POLR2B|5431 RNA polymerase II subunit B POLR2C|5432 RNA polymerase II subunit C POLR2D|5433 RNA polymerase II subunit D POLR2E|5434 RNA polymerase II subunit E POLR2F|5435 RNA polymerase II subunit F POLR2G|5436 RNA polymerase II subunit G POLR2H|5437 RNA polymerase II subunit H POLR2I|5438 RNA polymerase II subunit I POLR2J|5439 RNA polymerase II subunit J POLR2K|5440 RNA polymerase II subunit K POLR2L|5441 RNA polymerase II subunit L POLR3A|11128 RNA polymerase III subunit A POU5F1|5460 POU class 5 homeobox 1 PPM1A|5494 protein phosphatase, Mg2+/Mn2+ dependent 1A PPM1G|5496 protein phosphatase, Mg2+/Mn2+ dependent 1G PRKDC|5591 protein kinase, DNA-activated, catalytic polypeptide PRPF4|9128 pre-mRNA processing factor 4 PRPF40A|55660 pre-mRNA processing factor 40 homolog A PRPF6|24148 pre-mRNA processing factor 6 PRPF8|10594 pre-mRNA processing factor 8 PSMA2|5683 proteasome subunit alpha 2 PSMA4|5685 proteasome subunit alpha 4 PSMB2|5690 proteasome subunit beta 2 PSMB4|5692 proteasome subunit beta 4 PSMB5|5693 proteasome subunit beta 5 PSMC2|5701 proteasome 26S subunit, ATPase 2 PSMC4|5704 proteasome 26S subunit, ATPase 4 PTBP1|5725 polypyrimidine tract binding protein 1 PURA|5813 purine rich element binding protein A PXN|5829 paxillin RAD21|5885 RAD21 cohesin complex component RAD9A|5883 RAD9 checkpoint clamp component A RAPGEF2|9693 Rap guanine nucleotide exchange factor 2 RB1|5925 RB transcriptional corepressor 1 RBBP6|5930 RB binding protein 6, ubiquitin ligase RBBP8|5932 RB binding protein 8, endonuclease RBM5|10181 RNA binding motif protein 5 RBM8A|9939 RNA binding motif protein 8A RBMX|27316 RNA binding motif protein, X-linked RELA|5970 RELA proto-oncogene, NF-kB subunit RFC1|5981 replication factor C subunit 1 RNPS1|10921 RNA binding protein with serine rich domain 1 RNU11|26824 RNA, U11 small nuclear RNU12-2P|26823 RNA, U12 small nuclear 2, pseudogene RPAP2|79871 RNA polymerase II associated protein 2 RPAP3|79657 RNA polymerase II associated protein 3 RPL23A|6147 ribosomal protein L23a RPS23|6228 ribosomal protein S23 RPS3A|6189 ribosomal protein S3A RPS6KA1|6195 ribosomal protein S6 kinase A1 RPS6KA3|6197 ribosomal protein S6 kinase A3 RUNX2|860 runt related transcription factor 2 SART3|9733 squamous cell carcinoma antigen recognized by T-cells 3 SF3A1|10291 splicing factor 3a subunit 1 SF3A2|8175 splicing factor 3a subunit 2 SF3A3|10946 splicing factor 3a subunit 3 SF3B1|23451 splicing factor 3b subunit 1 SF3B14|51639 Splicing factor 3b subunit 14 SF3B2|10992 splicing factor 3b subunit 2 SF3B3|23450 splicing factor 3b subunit 3 SF3B4|10262 splicing factor 3b subunit 4 SF3B5|83443 splicing factor 3b subunit 5 SF4|57794 SURP and G-patch domain containing 1 SFRS1|6426 serine and arginine rich splicing factor 1 SFRS11|9295 serine and arginine rich splicing factor 11 SFRS12|140890 splicing regulatory glutamic acid and lysine rich protein 1 SFRS2|6427 serine and arginine rich splicing factor 2 SFRS3|6428 serine and arginine rich splicing factor 3 SFRS4|6429 serine and arginine rich splicing factor 4 SFRS5|6430 serine and arginine rich splicing factor 5 SFRS6|6431 serine and arginine rich splicing factor 6 SFRS7|6432 serine and arginine rich splicing factor 7 SFRS9|8683 serine and arginine rich splicing factor 9 SIRT1|23411 sirtuin 1 SKP1|6500 S-phase kinase associated protein 1 SKP2|6502 S-phase kinase associated protein 2 SLC2A4|6517 solute carrier family 2 member 4 SLC6A4|6532 solute carrier family 6 member 4 SMAD3|4088 SMAD family member 3 SWI/SNF related, matrix associated, actin dependent regulator of SMARCC1|6599 chromatin subfamily c member 1 SMC1A|8243 structural maintenance of 1A SMU1|55234 DNA replication regulator and spliceosomal factor SMURF1|57154 SMAD specific E3 ubiquitin protein ligase 1 SNAI2|6591 snail family transcriptional repressor 2 SNRNP200|23020 small nuclear ribonucleoprotein U5 subunit 200 SNRNP25|79622 small nuclear ribonucleoprotein U11/U12 subunit 25 SNRNP40|9410 small nuclear ribonucleoprotein U5 subunit 40 SNRNP70|6625 small nuclear ribonucleoprotein U1 subunit 70 SNRPA|6626 small nuclear ribonucleoprotein polypeptide A SNRPA1|6627 small nuclear ribonucleoprotein polypeptide A' SNRPB|6628 small nuclear ribonucleoprotein polypeptides B and B1 SNRPB2|6629 small nuclear ribonucleoprotein polypeptide B2 SNRPD1|6632 small nuclear ribonucleoprotein D1 polypeptide SNRPD2|6633 small nuclear ribonucleoprotein D2 polypeptide SNRPD3|6634 small nuclear ribonucleoprotein D3 polypeptide SNRPE|6635 small nuclear ribonucleoprotein polypeptide E SNRPF|6636 small nuclear ribonucleoprotein polypeptide F SNRPG|6637 small nuclear ribonucleoprotein polypeptide G SP1|6667 SP3|6670 Sp3 transcription factor SPDEF|25803 SAM pointed domain containing ETS transcription factor SREBF1|6720 sterol regulatory element binding transcription factor 1 SRP14|6727 signal recognition particle 14 SRRM1|10250 serine and arginine repetitive matrix 1 SRRM2|23524 serine/arginine repetitive matrix 2 SSBP1|6742 single stranded DNA binding protein 1 STAT1|6772 signal transducer and activator of transcription 1 STAT3|6774 signal transducer and activator of transcription 3 SUMO1|7341 small ubiquitin-like modifier 1 SYNCRIP|10492 synaptotagmin binding cytoplasmic RNA interacting protein SYNE2|23224 spectrin repeat containing nuclear envelope protein 2 TAF1|6872 TATA-box binding protein associated factor 1 TAF12|6883 TATA-box binding protein associated factor 12 TAF9|6880 TATA-box binding protein associated factor 9 TFAP2A|7020 transcription factor AP-2 alpha TFAP2C|7022 transcription factor AP-2 gamma THOC4|10189 Aly/REF export factor THRAP3|9967 associated protein 3 TOP2A|7153 topoisomerase (DNA) II alpha TOPBP1|11073 topoisomerase (DNA) II binding protein 1 TP53|7157 tumor protein TRAF6|7189 TNF receptor associated factor 6 TUBA4A|7277 tubulin alpha 4a TUBB|203068 tubulin beta class I TWIST1|7291 twist family bHLH transcription factor 1 TWIST2|117581 twist family bHLH transcription factor 2 TXNL4A|10907 thioredoxin like 4A TYMS|7298 thymidylate synthetase U2AF1|7307 U2 small nuclear RNA auxiliary factor 1 U2AF2|11338 U2 small nuclear RNA auxiliary factor 2 UBAP2L|9898 ubiquitin associated protein 2 like UBC|7316 ubiquitin C UBD|10537 ubiquitin D UBE2O|63893 ubiquitin conjugating enzyme E2 O UPF3B|65109 UPF3 regulator of nonsense transcripts homolog B (yeast) USF1|7391 upstream transcription factor 1 VDR|7421 vitamin D (1,25- dihydroxyvitamin D3) receptor VEGFA|7422 vascular endothelial growth factor A WBP2|23558 WW domain binding protein 2 WT1|7490 Wilms tumor 1 WWP1|11059 WW domain containing E3 ubiquitin protein ligase 1 WWTR1|25937 WW domain containing transcription regulator 1 YBX1|4904 Y-box binding protein 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation YWHAZ|7534 protein zeta YY1|7528 YY1 transcription factor ZEB1|6935 zinc finger E-box binding homeobox 1