Supplementary 1: YBX1 and its Interactors derived from UniHi, Metamatched and TRRUST databases. Gene_Id Description ABCB1|5243 ATP binding cassette subfamily B member 1 ACTB|60 actin beta AFF4|27125 AF4/FMR2 family member 4 AGT|183 angiotensinogen AKT1|207 AKT serine/threonine kinase 1 AMOTL1|154810 angiomotin like 1 ANAPC4|29945 anaphase promoting complex subunit 4 ANKRD2|26287 ankyrin repeat domain 2 APBB1|322 amyloid beta precursor protein binding family B member 1 APEX1|328 apurinic/apyrimidinic endodeoxyribonuclease 1 AR|367 androgen receptor ARID1A|8289 AT-rich interaction domain 1A ARRB1|408 arrestin beta 1 ARRB2|409 arrestin beta 2 ATF1|466 activating transcription factor 1 ATF2|1386 activating transcription factor 2 ATP6V1E1|529 ATPase H+ transporting V1 subunit E1 BARD1|580 BRCA1 associated RING domain 1 BCL6|604 B-cell CLL/lymphoma 6 BRCA1|672 BRCA1, DNA repair associated C19orf2|8725 URI1, prefoldin like chaperone C1QBP|708 complement C1q binding protein carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and CAD|790 dihydroorotase CALM1|801 calmodulin 1 CAND1|55832 cullin associated and neddylation dissociated 1 CBX8|57332 chromobox 8 CCAR1|55749 cell division cycle and apoptosis regulator 1 CCDC40|55036 coiled-coil domain containing 40 CCNB1|891 cyclin B1 CCNC|892 cyclin C CD2BP2|10421 CD2 cytoplasmic tail binding protein 2 CDC20|991 cell division cycle 20 CDH1|999 cadherin 1 CDK9|1025 cyclin dependent kinase 9 CDKN3|1033 cyclin dependent kinase inhibitor 3 CHD1|1105 chromodomain helicase DNA binding protein 1 CHTF18|63922 chromosome transmission fidelity factor 18 CKS2|1164 CDC28 protein kinase regulatory subunit 2 CLP1|10978 cleavage and polyadenylation factor I subunit 1 CMYA5|202333 cardiomyopathy associated 5 COBRA1|25920 negative elongation factor complex member B COPS5|10987 COP9 signalosome subunit 5 CPSF1|29894 cleavage and polyadenylation specific factor 1 CPSF2|53981 cleavage and polyadenylation specific factor 2 CPSF3|51692 cleavage and polyadenylation specific factor 3 CPSF6|11052 cleavage and polyadenylation specific factor 6 CPSF7|79869 cleavage and polyadenylation specific factor 7 CREB1|1385 cAMP responsive element binding protein 1 CSAD|51380 cysteine sulfinic acid decarboxylase CSDA|8531 Y-box binding protein 3 CSNK2A1|1457 casein kinase 2 alpha 1 CSTF1|1477 cleavage stimulation factor subunit 1 CSTF2|1478 cleavage stimulation factor subunit 2 CSTF3|1479 cleavage stimulation factor subunit 3 CTCF|10664 CCCTC-binding factor CUL1|8454 cullin 1 CUL2|8453 cullin 2 CUL3|8452 cullin 3 CUL4B|8450 cullin 4B CXCR4|7852 C-X-C motif chemokine receptor 4 DDX1|1653 DEAD-box helicase 1 DDX23|9416 DEAD-box helicase 23 DDX3X|1654 DEAD-box helicase 3, X-linked DHX30|22907 DExH-box helicase 30 DHX38|9785 DEAH-box helicase 38 DHX9|1660 DExH-box helicase 9 DIAPH1|1729 diaphanous related formin 1 DIMT1L|27292 DIM1 dimethyladenosine transferase 1 homolog DMXL1|1657 Dmx like 1 DNAJC8|22826 DnaJ heat shock protein family (Hsp40) member C8 DNMT1|1786 DNA methyltransferase 1 DYNC1H1|1778 dynein cytoplasmic 1 heavy chain 1 DYNC1I2|1781 dynein cytoplasmic 1 intermediate chain 2 DYNC1LI2|1783 dynein cytoplasmic 1 light intermediate chain 2 E2F1|1869 E2F transcription factor 1 EEF1A1|1915 eukaryotic translation elongation factor 1 alpha 1 EFTUD2|9343 elongation factor Tu GTP binding domain containing 2 EGFR|1956 epidermal growth factor receptor EGR1|1958 early growth response 1 EIF2B2|8892 eukaryotic translation initiation factor 2B subunit beta EIF2C1|26523 argonaute 1, RISC catalytic component EIF2C4|192670 argonaute 4, RISC catalytic component EIF2S1|1965 eukaryotic translation initiation factor 2 subunit alpha EIF3K|27335 eukaryotic translation initiation factor 3 subunit K EIF4A3|9775 eukaryotic translation initiation factor 4A3 ELK1|2002 ELK1, ETS transcription factor EP300|2033 E1A binding protein p300 EPRS|2058 glutamyl-prolyl-tRNA synthetase ERBB2|2064 erb-b2 receptor tyrosine kinase 2 ERBB3|2065 erb-b2 receptor tyrosine kinase 3 ESR1|2099 estrogen receptor 1 ETS1|2113 ETS proto-oncogene 1, transcription factor ETV4|2118 ETS variant 4 EWSR1|2130 EWS RNA binding protein 1 EZH2|2146 enhancer of zeste 2 polycomb repressive complex 2 subunit FAS|355 Fas cell surface death receptor FBXO33|254170 F-box protein 33 FKBP3|2287 FK506 binding protein 3 FLOT1|10211 flotillin 1 FMR1|2332 fragile X mental retardation 1 FN1|2335 fibronectin 1 FOXM1|2305 forkhead box M1 FUS|2521 FUS RNA binding protein G3BP1|10146 G3BP stress granule assembly factor 1 GATA3|2625 GATA binding protein 3 GATA4|2626 GATA binding protein 4 GIGYF2|26058 GRB10 interacting GYF protein 2 GIPC1|10755 GIPC PDZ domain containing family member 1 GRINL1A|81488 RNA polymerase II subunit M GSK3B|2932 glycogen synthase kinase 3 beta GTF2F1|2962 general transcription factor IIF subunit 1 GTF2F2|2963 general transcription factor IIF subunit 2 GZF1|64412 GDNF inducible zinc finger protein 1 HABP4|22927 hyaluronan binding protein 4 HDAC1|3065 histone deacetylase 1 HDAC2|3066 histone deacetylase 2 HDAC3|8841 histone deacetylase 3 HDGF|3068 heparin binding growth factor HIF1A|3091 hypoxia inducible factor 1 alpha subunit HIST1H1C|3006 histone cluster 1 H1 family member c HLA-C|3107 major histocompatibility complex, class I, C HNF4A|3172 hepatocyte nuclear factor 4 alpha HNRNPA0|10949 heterogeneous nuclear ribonucleoprotein A0 HNRNPA1|3178 heterogeneous nuclear ribonucleoprotein A1 HNRNPA2B1|318 1 heterogeneous nuclear ribonucleoprotein A2/B1 HNRNPA3|220988 heterogeneous nuclear ribonucleoprotein A3 HNRNPAB|3182 heterogeneous nuclear ribonucleoprotein A/B HNRNPC|3183 heterogeneous nuclear ribonucleoprotein C (C1/C2) HNRNPD|3184 heterogeneous nuclear ribonucleoprotein D HNRNPF|3185 heterogeneous nuclear ribonucleoprotein F HNRNPH1|3187 heterogeneous nuclear ribonucleoprotein H1 HNRNPH2|3188 heterogeneous nuclear ribonucleoprotein H2 HNRNPK|3190 heterogeneous nuclear ribonucleoprotein K HNRNPL|3191 heterogeneous nuclear ribonucleoprotein L HNRNPM|4670 heterogeneous nuclear ribonucleoprotein M HNRNPR|10236 heterogeneous nuclear ribonucleoprotein R HNRNPU|3192 heterogeneous nuclear ribonucleoprotein U HNRNPUL1|1110 0 heterogeneous nuclear ribonucleoprotein U like 1 HOXB7|3217 homeobox B7 HSPA1A|3303 heat shock protein family A (Hsp70) member 1A HSPA2|3306 heat shock protein family A (Hsp70) member 2 HSPA5|3309 heat shock protein family A (Hsp70) member 5 IFIT1|3434 interferon induced protein with tetratricopeptide repeats 1 IFIT2|3433 interferon induced protein with tetratricopeptide repeats 2 IFIT3|3437 interferon induced protein with tetratricopeptide repeats 3 IL7R|3575 interleukin 7 receptor ILF2|3608 interleukin enhancer binding factor 2 IQCB1|9657 IQ motif containing B1 IREB2|3658 iron responsive element binding protein 2 IRF1|3659 interferon regulatory factor 1 IRS1|3667 insulin receptor substrate 1 ITGA4|3676 integrin subunit alpha 4 JAM2|58494 junctional adhesion molecule 2 JUN|3725 Jun proto-oncogene, AP-1 transcription factor subunit KHDRBS2|202559 KH RNA binding domain containing, signal transduction associated 2 KIAA0101|9768 PCNA clamp associated factor KLF4|9314 Kruppel like factor 4 KLF5|688 Kruppel like factor 5 KPNA2|3838 karyopherin subunit alpha 2 LARP1|23367 La ribonucleoprotein domain family member 1 LCP2|3937 lymphocyte cytosolic protein 2 LMAN1|3998 lectin, mannose binding 1 LSM2 homolog, U6 small nuclear RNA and mRNA degradation LSM2|57819 associated LSM3 homolog, U6 small nuclear RNA and mRNA degradation LSM3|27258 associated MAGOH|4116 mago homolog, exon junction complex core component MAP2|4133 microtubule associated protein 2 MAP3K14|9020 mitogen-activated protein kinase kinase kinase 14 MAPK1|5594 mitogen-activated protein kinase 1 MAPK13|5603 mitogen-activated protein kinase 13 MCCC2|64087 methylcrotonoyl-CoA carboxylase 2 MECP2|4204 methyl-CpG binding protein 2 MED6|10001 mediator complex subunit 6 MEPCE|56257 methylphosphate capping enzyme MET|4233 MET proto-oncogene, receptor tyrosine kinase METAP2|10988 methionyl aminopeptidase 2 MMP13|4322 matrix metallopeptidase 13 MMP2|4313 matrix metallopeptidase 2 MNAT1|4331 MNAT1, CDK activating kinase assembly factor MTA1|9112 metastasis associated 1 MVP|9961 major vault protein MYC|4609 MYC proto-oncogene, bHLH transcription factor MYCN|4613 MYCN proto-oncogene, bHLH transcription factor NAP1L1|4673 nucleosome assembly protein 1 like 1 NAT10|55226 N-acetyltransferase 10 NCBP1|4686 nuclear cap binding protein subunit 1 NCBP2|22916 nuclear cap binding protein subunit 2 NCOR2|9612 nuclear receptor corepressor 2 neural precursor cell expressed, developmentally down-regulated 4, E3 NEDD4|4734 ubiquitin protein ligase NEDD8|4738 neural precursor cell expressed, developmentally down-regulated 8 NFKB1|4790 nuclear factor kappa B subunit 1 NFX1|4799 nuclear transcription factor, X-box binding 1 NFYA|4800 nuclear transcription factor Y subunit alpha NFYB|4801 nuclear transcription factor Y subunit beta NFYC|4802 nuclear transcription factor Y subunit gamma NHP2L1|4809 SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) NMT1|4836 N-myristoyltransferase 1 NOP56|10528 NOP56 ribonucleoprotein NOS2|4843 nitric oxide synthase 2 NPM1|4869 nucleophosmin NR4A1|3164 nuclear receptor subfamily 4 group A member 1 NUDT21|11051 nudix hydrolase 21 PA2G4|5036 proliferation-associated 2G4 PABPN1|8106 poly(A) binding protein nuclear 1 PAN2|9924 PAN2 poly(A) specific ribonuclease subunit PAPOLA|10914 poly(A) polymerase alpha PARP1|142 poly(ADP-ribose) polymerase 1 PAX3|5077 paired box 3 PAX5|5079 paired