Supplementary Table 1A. significantly altered in A4573 ESFT cells following BMI-1knockdown genesymbol genedescription siControl siBMI1 FC Direction P-value AASS aminoadipate-semialdehyde synthase | tetra-peptide repeat -like6.68 7.24 1.5 Up 0.007 ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 | neural5.44 proliferation,6.3 differentiation1.8 and Upcontrol, 1 0.006 ABHD4 abhydrolase domain containing 4 7.51 6.69 1.8 Down 0.002 ACACA acetyl-Coenzyme A carboxylase alpha | peroxiredoxin 5 | similar6.2 to High mobility7.26 group2.1 UpB1 (High mobility0.009 group protein 1) (HMG-1) (Amphoterin) (Heparin-binding protein p30) | Coenzyme A synthase ACAD9 acyl-Coenzyme A dehydrogenase family, member 9 9.25 8.59 1.6 Down 0.008 ACBD3 acyl-Coenzyme A binding domain containing 3 7.89 8.53 1.6 Up 0.008 ACCN2 amiloride-sensitive cation channel 2, neuronal 5.47 6.28 1.8 Up 0.005 ACIN1 apoptotic chromatin condensation inducer 1 7.15 7.79 1.6 Up 0.008 ACPL2 acid phosphatase-like 2 6.04 7.6 2.9 Up 0.000 ACSL4 acyl-CoA synthetase long-chain family member 4 6.72 5.8 1.9 Down 0.001 ACTA2 , alpha 2, , aorta 9.18 8.44 1.7 Down 0.003 ACYP1 acylphosphatase 1, erythrocyte (common) type 7.09 7.66 1.5 Up 0.009 ADA deaminase 6.34 7.1 1.7 Up 0.009 ADAL -like 7.88 6.89 2.0 Down 0.006 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 6.57 7.65 2.1 Up 0.000 ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) 6.49 7.13 1.6 Up 0.008 ADCY9 adenylate cyclase 9 6.5 7.18 1.6 Up 0.002 ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) 5.71type I 6.38 1.6 Up 0.002 ADI1 acireductone dioxygenase 1 6.65 7.35 1.6 Up 0.009 ADRBK1 adrenergic, beta, receptor kinase 1 | repeat domain 136.95 family, member7.59 D 1.6 Up 0.002 AES amino-terminal enhancer of split 7.72 8.45 1.7 Up 0.005 AGPAT3 1-acylglycerol-3-phosphate O- 3 9.42 8.76 1.6 Down 0.003 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic7.16 acid acyltransferase,8.23 2.1 epsilon) Up 0.005 AKAP2 A kinase (PRKA) anchor protein 2 | paralemmin 2 | PALM2-AKAP26.55 protein7.14 1.5 Up 0.005 AKAP8 A kinase (PRKA) anchor protein 8 6.08 7.13 2.1 Up 0.001 AKT1S1 AKT1 1 (proline-rich) 6.56 7.37 1.8 Up 0.001 ALDH1A3 aldehyde dehydrogenase 1 family, member A3 5.95 6.55 1.5 Up 0.006 ALDH9A1 aldehyde dehydrogenase 9 family, member A1 8.55 9.96 2.7 Up 0.000 AMDHD2 domain containing 2 | cementum protein 1 7.39 6.66 1.7 Down 0.003 ANAPC1 anaphase promoting complex subunit 1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase7.61 6.95 1.6 Down 2 0.007 ANGPTL2 angiopoietin-like 2 5.95 6.67 1.6 Up 0.007 ANKDD1A and containing 1A 5.33 5.97 1.6 Up 0.005 ANKH ankylosis, progressive homolog (mouse) | CHK1 checkpoint homolog6.1 (S. pombe)6.63 1.4 Up 0.006 ANKRD29 ankyrin repeat domain 29 6.05 6.78 1.7 Up 0.002 ANKS1A ankyrin repeat and domain containing 1A 6.65 5.85 1.7 Down 0.006 AOF2 amine oxidase (flavin containing) domain 2 | similar to TFIIH basal8.9 transcription9.84 factor 1.9complex Upp44 subunit (Basic0.000 2 44 kDa subunit) (BTF2-p44) (General transcription factor IIH polypeptide 2) APAF1 apoptotic peptidase activating factor 1 8.76 6.92 3.6 Down 0.000 APBB3 amyloid beta (A4) precursor protein-binding, family B, member8.97 3 8.07 1.9 Down 0.002 APCDD1 adenomatosis polyposis coli down-regulated 1 9.22 9.87 1.6 Up 0.002 APEH N-acylaminoacyl-peptide | macrophage stimulating, 6.77pseudogene7.46 9 1.6 Up 0.002 API5 apoptosis inhibitor 5 9.69 8.46 2.3 Down 0.000 APLP1 amyloid beta (A4) precursor-like protein 1 5.76 6.6 1.8 Up 0.010 APOBEC3D apolipoprotein B mRNA editing , catalytic polypeptide-like7.17 3D (putative)6.64 1.4 Down 0.006 ARG2 , type II | similar to High mobility group protein B1 (High5.9 mobility6.78 group protein1.8 1) (HMG-1)Up (Amphoterin)0.001 (Heparin-binding protein p30) | similar to protein kinase C, eta ARHGAP17 Rho GTPase activating protein 17 7.07 8.23 2.2 Up 0.003 ARHGAP19 Rho GTPase activating protein 19 8.94 7.94 2.0 Down 0.004 ARHGAP19 Rho GTPase activating protein 19 7.92 7.29 1.5 Down 0.003 ARID1B AT rich interactive domain 1B (SWI1-like) | similar to AT rich interactive5.67 domain6.22 1B (SWI1-like)1.5 Up isoform 1 0.008 ARL1 ADP-ribosylation factor-like 1 9.21 8.33 1.8 Down 0.008 ARL13B ADP-ribosylation factor-like 13B 7.36 8.3 1.9 Up 0.000 ARL5B ADP-ribosylation factor-like 5B | similar to Programmed cell death8.28 protein6.98 8, mitochondrial2.5 precursorDown (Apoptosis-inducing0.000 factor) ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 11.42 10.76 1.6 Down 0.005 ARMCX1 armadillo repeat containing, X-linked 1 7.93 7.16 1.7 Down 0.007 ARNTL aryl hydrocarbon receptor nuclear translocator-like 6.15 5.56 1.5 Down 0.008 ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) | KIAA17516.25 | TL132 pseudogene6.89 1.6 Up 0.005 ATE1 1 | KIAA1529 6.15 7.12 2.0 Up 0.001 ATF1 activating transcription factor 1 5.82 6.58 1.7 Up 0.001 ATF2 activating transcription factor 2 7.22 8.4 2.3 Up 0.001 ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae) | ATP-binding6.81 cassette,7.51 sub-family1.6 B (MDR/TAP),Up member0.004 6 ATP10D ATPase, Class V, type 10D 7.22 6.28 1.9 Down 0.006 ATP11C ATPase, Class VI, type 11C 7.34 8.9 2.9 Up 0.000 ATP13A3 ATPase type 13A3 7.94 8.75 1.8 Up 0.002 ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 6.06 6.68 1.5 Up 0.004 ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 9.11 8.2 1.9 Down 0.008 ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 9.92 9.22 1.6 Down 0.005 AYTL2 7.18 8.07 1.9 Up 0.001 AZIN1 antizyme inhibitor 1 10.53 9.28 2.4 Down 0.000 B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 5.84 6.84 2.0 Up 0.000 B4GALNT3 beta-1,4-N-acetyl-galactosaminyl 3 5.44 5.9 1.4 Up 0.008 B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide7.49 5 8.35 1.8 Up 0.009 B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide7.8 6 6.82 2.0 Down 0.002 BAALC and acute leukemia, cytoplasmic | hypothetical protein FLJ104895.89 7.07 2.3 Up 0.001 BAG4 BCL2-associated athanogene 4 8.15 9.01 1.8 Up 0.003 BAI2 brain-specific angiogenesis inhibitor 2 | collagen, type XVI, alpha5.79 1 6.45 1.6 Up 0.003 BARX1 BarH-like homeobox 1 6.4 7.07 1.6 Up 0.003 BASP1 brain abundant, membrane attached signal protein 1 | similar 8.26to Aurora kinase9.65 A-interacting2.6 proteinUp (AURKA-interacting0.000 protein) BCL2L13 BCL2-like 13 (apoptosis facilitator) | hypothetical protein ZD77D087.87 | CHK16.85 checkpoint 2.0homologDown (S. pombe) | 0.005ring finger protein 141 BCL9 B-cell CLL/lymphoma 9 7.05 7.64 1.5 Up 0.008 BCOR BCL6 co-repressor | hypothetical protein LOC730590 | hypothetical7.57 protein8.1 LOC7280681.4 Up 0.006 BET1 7.96 8.46 1.4 Up 0.010 BGN biglycan 6.6 7.66 2.1 Up 0.001 BHLHB5 basic helix-loop-helix domain containing, class B, 5 8.22 9.28 2.1 Up 0.001 BIRC2 baculoviral IAP repeat-containing 2 9.28 8.13 2.2 Down 0.010 BIRC3 baculoviral IAP repeat-containing 3 10.15 8.02 4.4 Down 0.000 BMI1 B lymphoma Mo-MLV insertion region (mouse) | COMM domain8.31 containing 36.2 4.3 Down 0.000 BMP7 bone morphogenetic protein 7 (osteogenic protein 1) 6.18 6.95 1.7 Up 0.001 BOC Boc homolog (mouse) 5.3 6.14 1.8 Up 0.002 BPGM 2,3-bisphosphoglycerate mutase 8.77 8.25 1.4 Down 0.008 BST2 bone marrow stromal cell antigen 2 7.14 6.2 1.9 Down 0.002 BTBD5 BTB (POZ) domain containing 5 8.26 6.76 2.8 Down 0.000 BTN3A1 butyrophilin, subfamily 3, member A1 8.28 7.18 2.1 Down 0.001 BVES blood vessel epicardial substance 6.92 6.14 1.7 Down 0.006 C10orf72 10 open reading frame 72 5.82 6.55 1.7 Up 0.001 C11orf24 chromosome 11 open reading frame 24 6.99 7.86 1.8 Up 0.003 C11orf51 chromosome 11 open reading frame 51 7.49 8.3 1.8 Up 0.003 C11orf59 chromosome 11 open reading frame 59 7.46 8.44 2.0 Up 0.001 C11orf60 chromosome 11 open reading frame 60 8.57 7.8 1.7 Down 0.008 C12orf49 chromosome 12 open reading frame 49 6.61 7.39 1.7 Up 0.001 C14orf100 chromosome 14 open reading frame 100 9.32 7.89 2.7 Down 0.001 C14orf122 chromosome 14 open reading frame 122 7.06 8.22 2.2 Up 0.000 C14orf32 chromosome 14 open reading frame 32 9.12 9.7 1.5 Up 0.010 C15orf39 chromosome 15 open reading frame 39 | similar to COMM domain5.91 containing6.38 4 1.4 Up 0.010 C16orf58 chromosome 16 open reading frame 58 7.85 7.12 1.7 Down 0.004 C17orf68 open reading frame 68 8.17 7.36 1.8 Down 0.002 C18orf25 chromosome 18 open reading frame 25 7.13 6.24 1.9 Down 0.001 C19orf24 open reading frame 24 7.63 8.28 1.6 Up 0.008 C1orf124 chromosome 1 open reading frame 124 7.63 6.55 2.1 Down 0.003 C1orf128 chromosome 1 open reading frame 128 | SET domain containing7.51 5 | lysophospholipase8.4 1.9 II | lysophospholipaseUp 0.004 II 1 | similar to Acyl-protein thioesterase 2 (Lysophospholipase II) (LPL-I) C1orf38 chromosome 1 open reading frame 38 5.26 5.84 1.5 Up 0.008 C1orf55 chromosome 1 open reading frame 55 8.76 8.01 1.7 Down 0.005 C1orf75 chromosome 1 open reading frame 75 6.93 7.6 1.6 Up 0.005 C1orf86 chromosome 1 open reading frame 86 6 6.67 1.6 Up 0.007 C1QL1 complement component 1, q subcomponent-like 1 6.26 7.17 1.9 Up 0.005 C20orf55 chromosome 20 open reading frame 55 6.69 7.31 1.5 Up 0.009 C20orf77 chromosome 20 open reading frame 77 7.54 6.99 1.5 Down 0.007 C21orf25 chromosome 21 open reading frame 25 7.96 7.22 1.7 Down 0.002 C21orf45 chromosome 21 open reading frame 45 9.99 9.41 1.5 Down 0.004 C21orf6 chromosome 21 open reading frame 6 | BTB (POZ) domain containing8.78 5 7.87 1.9 Down 0.003 C22orf5 open reading frame 5 | KIAA1660 protein 6.24 7.11 1.8 Up 0.002 C2orf37 open reading frame 37 7.01 6.11 1.9 Down 0.009 C4orf34 chromosome 4 open reading frame 34 7.48 6.6 1.8 Down 0.000 C6orf58 open reading frame 58 9.53 7.6 3.8 Down 0.000 C7orf28A chromosome 7 open reading frame 28A | olfactory receptor, family8.63 7, subfamily7.85 E, member1.7 91Down pseudogene |0.005 olfactory receptor, family 7, subfamily E, member 156 pseudogene | asparagine synthetase | hypothetical supported by BC044942 | hypothetical LOC389634 | hypothetical protein LOC729732 | hypothetical LOC497257 | hypothetical protein LOC730919 | hypothetical protein LOC649305 | similar to CG14980-PB | MGC72080 pseudogene | similar to Protein C11orf2 (Another new gene 2 protein) | similar to 40S ribosomal protein S3a (V-fos transformation effector protein) C7orf41 chromosome 7 open reading frame 41 5.88 6.79 1.9 Up 0.004 C7orf43 chromosome 7 open reading frame 43 7.48 6.92 1.5 Down 0.006 C9orf86 chromosome 9 open reading frame 86 | KIAA1984 | hypothetical6.7 protein LOC6480267.35 1.6 Up 0.005 C9orf91 chromosome 9 open reading frame 91 | hypothetical protein LOC7293316.15 |6.71 hypothetical1.5 protein LOC730506Up 0.009 CABLES1 Cdk5 and Abl enzyme substrate 1 5.5 6.33 1.8 Up 0.005 CACHD1 cache domain containing 1 6.79 7.5 1.6 Up 0.004 CACNA1G calcium channel, voltage-dependent, alpha 1G subunit 5.34 6.41 2.1 Up 0.000 CACNB3 calcium channel, voltage-dependent, beta 3 subunit 6.32 7.46 2.2 Up 0.001 CALCRL calcitonin receptor-like 8.43 7.11 2.5 Down 0.001 CALML4 -like 4 5.81 6.61 1.7 Up 0.001 CAMKV CaM kinase-like vesicle-associated | macrophage stimulating 15.76 receptor (c-met-related6.62 1.8 Upkinase) 0.001 CARKL carbohydrate kinase-like | transient receptor potential cation channel,8.21 subfamily7.63 V, member1.5 1Down 0.005 CARM1 coactivator-associated arginine methyltransferase 1 7.32 7.88 1.5 Up 0.007 CASP8 caspase 8, apoptosis-related cysteine peptidase 7.03 6.26 1.7 Down 0.003 CBARA1 calcium binding atopy-related autoantigen 1 | inositol polyphosphate-5-phosphatase,8.16 7.36 145kDa1.7 |Down chromosome 0.0076 open reading frame 167 CBR4 carbonyl reductase 4 8.2 7.26 1.9 Down 0.004 CCDC25 coiled-coil domain containing 25 | X-ray repair complementing8.88 defective repair7.99 in Chinese1.9 hamsterDown cells 2 | late0.009 cornified envelope 5A CCDC3 coiled-coil domain containing 3 | similar to 60S ribosomal protein5.8 L5 | similar6.49 to ribosomal1.6 proteinUp L5 0.002 CCDC55 coiled-coil domain containing 55 | family with sequence similarity6.97 73, member6.26 A | similar1.6 to coiled-coilDown domain0.009 containing 55 CCNDBP1 cyclin D-type binding-protein 1 8.17 7.27 1.9 Down 0.005 CCNG2 cyclin G2 8.7 7.92 1.7 Down 0.002 CCT8 chaperonin containing TCP1, subunit 8 (theta) 9.35 9.98 1.5 Up 0.008 CD2AP CD2-associated protein | ribosomal protein S12 8.52 6.84 3.2 Down 0.000 CD320 8.18 8.73 1.5 Up 0.003 CDH23 cadherin-like 23 5.19 5.95 1.7 Up 0.007 CDH24 cadherin-like 24 6.14 6.66 1.4 Up 0.007 CDK2AP1 CDK2-associated protein 1 9.49 10.23 1.7 Up 0.004 CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity6.67 phosphatase)8.16 2.8 Up 0.000 CDON Cdon homolog (mouse) 6.25 6.85 1.5 Up 0.006 CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 | 5.39carcinoembryonic5.92 antigen-related1.4 Upcell adhesion 0.005molecule 7 | hypothetical protein LOC732005 CECR1 cat eye syndrome chromosome region, candidate 1 | queuine 6.89tRNA-ribosyltransferase7.37 1.41 (tRNA-guanineUp transglycosylase)0.008 | cell cycle related kinase CEECAM1 cerebral endothelial cell adhesion molecule 1 5.62 6.55 1.9 Up 0.004 CENTD2 centaurin, delta 2 7.94 7.32 1.5 Down 0.002 CENTG3 centaurin, gamma 3 7.11 7.68 1.5 Up 0.003 CEP57 centrosomal protein 57kDa 8.24 7.35 1.9 Down 0.008 CGGBP1 CGG triplet repeat binding protein 1 | hypothetical protein LOC7283978.78 | hypothetical7.7 protein2.1 LOC730652Down 0.006 CGI-09 7.76 8.47 1.6 Up 0.006 CGI-38 brain specific protein 5.87 6.66 1.7 Up 0.004 CHD3 chromodomain helicase DNA binding protein 3 | small Cajal body-specific8.37 RNA9.01 21 1.6 Up 0.005 CHEK1 CHK1 checkpoint homolog (S. pombe) 9.33 8.48 1.8 Down 0.009 CHEK1 CHK1 checkpoint homolog (S. pombe) | phosphoribosylformylglycinamidine7.25 7.81 synthase (FGAR1.5 amidotransferase)Up 0.007 CHUK conserved helix-loop-helix ubiquitous kinase | hypothetical protein8.29 LOC3997617.39 1.9 Down 0.006 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal8.44 domain,9.47 2 2.0 Up 0.009 CKB creatine kinase, brain 7.55 8.19 1.6 Up 0.008 CLCN2 chloride channel 2 5.87 6.7 1.8 Up 0.001 CLCN3 chloride channel 3 | similar to chloride channel 3 isoform b 8.94 8.07 1.8 Down 0.004 CLCN7 chloride channel 7 8.22 7.58 1.6 Down 0.004 CLDND1 claudin domain containing 1 8.47 9.09 1.5 Up 0.004 CLIC2 chloride intracellular channel 2 | twinfilin, actin-binding protein,6.79 homolog 16.06 (Drosophila)1.7 Down 0.004 CLIC4 chloride intracellular channel 4 | similar to Beta-glucuronidase9.73 precursor 11.33| similar to Chloride3.0 intracellularUp channel0.000 protein 4 (Intracellular chloride ion channel protein p64H1) | adducin 3 (gamma) CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit8.67 homolog (E.9.71 coli) 2.1 Up 0.001 CLU clusterin 9.29 8.67 1.5 Down 0.007 CMTM7 CKLF-like MARVEL transmembrane domain containing 7 6.95 7.63 1.6 Up 0.002 CNIH2 cornichon homolog 2 (Drosophila) | kinesin light chain 2 5.99 6.59 1.5 Up 0.004 CNIH4 cornichon homolog 4 (Drosophila) | interferon stimulated exonuclease8.82 gene9.39 20kDa-like1.5 2 Up 0.008 CNOT6 CCR4-NOT transcription complex, subunit 6 7.32 8.09 1.7 Up 0.004 CNTNAP2 contactin associated protein-like 2 | RAN, member RAS oncogene7.04 family 7.72 1.6 Up 0.007 COG5 component of oligomeric golgi complex 5 8.67 7.98 1.6 Down 0.006 COL13A1 collagen, type XIII, alpha 1 6.09 6.81 1.6 Up 0.003 COL16A1 collagen, type XVI, alpha 1 | brain-specific angiogenesis inhibitor6.03 2 7.01 2.0 Up 0.002 COL1A2 collagen, type I, alpha 2 10.43 9.67 1.7 Down 0.002 COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal9.02 dominant)8.28 1.7 Down 0.001 COL4A1 collagen, type IV, alpha 1 7.39 8.46 2.1 Up 0.002 COL4A2 collagen, type IV, alpha 2 6.4 7.26 1.8 Up 0.008 COL5A1 collagen, type V, alpha 1 6.77 7.45 1.6 Up 0.001 COL5A2 collagen, type V, alpha 2 9.5 8.28 2.3 Down 0.001 COL6A1 collagen, type VI, alpha 1 6.32 7.23 1.9 Up 0.001 COL6A2 collagen, type VI, alpha 2 6.78 7.34 1.5 Up 0.005 CORO1A coronin, actin binding protein, 1A | interferon stimulated exonuclease5.75 gene6.72 20kDa-like 2.02 | coronin,Up actin binding0.000 protein, 1A pseudogene COX15 8.45 7.51 1.9 Down 0.002 CPEB4 cytoplasmic polyadenylation element binding protein 4 6.87 6.27 1.5 Down 0.006 CPNE7 copine VII | similar to Copine-7 (Copine VII) 5.93 6.71 1.7 Up 0.002 CPXM1 carboxypeptidase X (M14 family), member 1 5.7 6.39 1.6 Up 0.003 CRABP1 cellular retinoic acid binding protein 1 10.62 11.32 1.6 Up 0.002 CREBL2 cAMP responsive element binding protein-like 2 8.62 7.7 1.9 Down 0.001 CRMP1 collapsin response mediator protein 1 5.86 6.44 1.5 Up 0.006 CRYM crystallin, mu | hypothetical LOC646823 5.47 6.06 1.5 Up 0.004 CS | specific peptidase 52 | transmembrane9.97 protein10.45 4 1.4 Up 0.008 CSNK1D casein kinase 1, delta 8.91 8.01 1.9 Down 0.001 CTSC cathepsin C 7.16 7.85 1.6 Up 0.009 CTSD cathepsin D | similar to RIKEN cDNA 6330512M04 gene (mouse)9.15 8.6 1.5 Down 0.007 CTXN1 cortexin 1 7.24 8.08 1.8 Up 0.003 CXCL14 chemokine (C-X-C motif) ligand 14 5.61 6.22 1.5 Up 0.004 CXorf39 chromosome X open reading frame 39 8 6.87 2.2 Down 0.000 CYB5B cytochrome b5 type B (outer mitochondrial membrane) | hypothetical9.73 protein10.38 LOC7302731.6 Up 0.003 CYB5D2 cytochrome b5 domain containing 2 | ankyrin repeat and FYVE7.21 domain containing6.64 1 1.5 Down 0.006 CYBASC3 cytochrome b, ascorbate dependent 3 9.07 7.95 2.2 Down 0.001 CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 5.71 6.46 1.7 Up 0.001 DAB2IP DAB2 interacting protein 5.75 6.52 1.7 Up 0.005 DAK dihydroxyacetone kinase 2 homolog (S. cerevisiae) 7.79 7.07 1.6 Down 0.009 DAP3 death associated protein 3 7.5 8.69 2.3 Up 0.006 DBNL drebrin-like 8.9 7.98 1.9 Down 0.001 DCAKD dephospho-CoA kinase domain containing 7.22 6.59 1.5 Down 0.009 DCBLD2 discoidin, CUB and LCCL domain containing 2 7.74 8.43 1.6 Up 0.010 DCHS1 dachsous 1 (Drosophila) 6.31 7.18 1.8 Up 0.005 DCP2 6.98 6.18 1.7 Down 0.001 DCXR dicarbonyl/L-xylulose reductase 7.87 8.48 1.5 Up 0.002 DDI2 DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae) | regulatory7.8 solute6.69 carrier protein,2.2 familyDown 1, member0.001 1 DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 8.09 8.89 1.7 Up 0.009 DHX40P DEAH (Asp-Glu-Ala-His) box polypeptide 40 pseudogene 6.95 8.16 2.3 Up 0.001 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 8.44 9.24 1.7 Up 0.006 DIDO1 death inducer-obliterator 1 7.57 6.76 1.8 Down 0.005 DIDO1 death inducer-obliterator 1 7.05 7.98 1.9 Up 0.001 DKFZP564O0823 6.86 6.28 1.5 Down 0.005 DKK2 dickkopf homolog 2 (Xenopus laevis) 7.49 8.28 1.7 Up 0.003 DKK3 dickkopf homolog 3 (Xenopus laevis) 5.54 6.34 1.7 Up 0.004 DLG4 discs, large homolog 4 (Drosophila) 6.19 6.81 1.5 Up 0.002 DLGAP4 discs, large (Drosophila) homolog-associated protein 4 6.51 7.1 1.5 Up 0.003 DLX5 distal-less homeobox 5 7.06 7.94 1.8 Up 0.008 DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 | dehydrogenase8.16 E1 and7.42 transketolase1.7 domainDown containing 10.001 DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 | similar to centaurin,8.5 gamma-like9.22 family,1.6 memberUp 1 0.009 DNER delta/notch-like EGF repeat containing | hypothetical protein LOC7299905.71 6.44 1.7 Up 0.002 DNMT1 DNA (cytosine-5-)-methyltransferase 1 7.89 9.15 2.4 Up 0.000 DOCK6 dedicator of cytokinesis 6 5.31 5.88 1.5 Up 0.008 DSG3 desmoglein 3 (pemphigus vulgaris antigen) 6.16 5.52 1.6 Down 0.008 DSP desmoplakin 5.29 5.93 1.6 Up 0.006 DUS3L dihydrouridine synthase 3-like (S. cerevisiae) 6.89 7.94 2.1 Up 0.000 DUSP26 dual specificity phosphatase 26 (putative) 6.63 7.73 2.1 Up 0.001 DUSP3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)8.5 | 7.63basigin (Ok blood1.8 group)Down 0.000 DUSP6 dual specificity phosphatase 6 6.69 7.84 2.2 Up 0.002 transcription factor 3 5.64 6.49 1.8 Up 0.005 ECH1 enoyl Coenzyme A hydratase 1, peroxisomal 9.63 9.03 1.5 Down 0.003 ECM1 protein 1 6.39 7.37 2.0 Up 0.000 ECOP EGFR-coamplified and overexpressed protein | similar to EGFR-coamplified7.85 8.52 and overexpressed1.6 proteinUp | hypothetical0.007 protein LOC729086 EDG7 endothelial differentiation, lysophosphatidic acid G-protein-coupled6.15 receptor,6.85 7 1.6 Up 0.008 EDIL3 EGF-like repeats and discoidin I-like domains 3 6.88 8.31 2.7 Up 0.000 EFHD1 EF-hand domain family, member D1 6.27 7.19 1.9 Up 0.002 EFNB1 ephrin-B1 7.21 8.05 1.8 Up 0.002 EGF (beta-urogastrone) 7.03 6.15 1.8 Down 0.001 EIF1AP1 eukaryotic translation initiation factor 1A pseudogene 1 | eukaryotic7.76 translation8.85 initiation2.1 factor Up1A, X-linked 0.002 EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa6.92 7.44 1.4 Up 0.010 EIF2C2 eukaryotic translation initiation factor 2C, 2 | hypothetical protein6.5 LOC2861097.31 1.8 Up 0.002 EIF4A3 eukaryotic translation initiation factor 4A, isoform 3 8.64 9.19 1.5 Up 0.009 EIF4E2 eukaryotic translation initiation factor 4E family member 2 9.07 9.87 1.7 Up 0.001 EIF4E3 eukaryotic translation initiation factor 4E family member 3 | TL1325.66 pseudogene6.38 1.6 Up 0.009 ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu7.25 antigen R)6.45 | translocase1.7 of innerDown mitochondrial0.001 membrane 44 homolog (yeast) ELMOD2 ELMO/CED-12 domain containing 2 8.07 6.49 3.0 Down 0.000 ELN elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)6.91 | LIM domain7.51 kinase1.5 1 Up 0.005 EML3 echinoderm microtubule associated protein like 3 5.85 6.64 1.7 Up 0.003 EMP2 epithelial membrane protein 2 6.8 8.53 3.3 Up 0.000 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 8.95 7.6 2.5 Down 0.000 EPDR1 ependymin related protein 1 (zebrafish) 8.55 6.85 3.2 Down 0.000 ETNK1 ethanolamine kinase 1 7.43 6.43 2.0 Down 0.009 EXDL2 exonuclease 3'-5' domain-like 2 7.3 6.28 2.0 Down 0.003 EYA2 eyes absent homolog 2 (Drosophila) 5.52 6.41 1.9 Up 0.001 F2R coagulation factor II (thrombin) receptor 7.45 9.22 3.4 Up 0.000 FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like),7.29 member 6.26A2 2.0 Down 0.001 FAM35A family with sequence similarity 35, member A | X-ray repair complementing6.67 7.26 defective repair1.5 in ChineseUp hamster0.008 cells 2 | similar to family with sequence similarity 35, member A | hypothetical protein LOC651865 FAM49A family with sequence similarity 49, member A 6.89 8.13 2.4 Up 0.001 FAM57A family with sequence similarity 57, member A 7.74 8.3 1.5 Up 0.004 FAM83D family with sequence similarity 83, member D 8.34 9.13 1.7 Up 0.004 FAM84B family with sequence similarity 84, member B 9.6 10.3 1.6 Up 0.006 FAM91A1 family with sequence similarity 91, member A1 | similar to F33H2.28.2 7.37 1.8 Down 0.003 FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)7.65 8.38 | DEAD/H1.7 (Asp-Glu-Ala-Asp/His)Up 0.008 box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) | hypothetical protein LOC730655 | hypothetical protein LOC728155 FASN 7.08 8.18 2.1 Up 0.000 FBN3 fibrillin 3 5.48 6.1 1.5 Up 0.008 FCHSD2 FCH and double SH3 domains 2 | neuregulin 4 8.35 7.38 2.0 Down 0.009 FGD6 FYVE, RhoGEF and PH domain containing 6 8.26 6.72 2.9 Down 0.000 FGF13 fibroblast growth factor 13 | hypothetical protein LOC729045 |7.02 hypothetical7.87 protein LOC7305281.8 Up 0.001 FGFR4 fibroblast growth factor receptor 4 5.89 6.67 1.7 Up 0.001 FHL3 four and a half LIM domains 3 6.74 7.39 1.6 Up 0.009 FLJ10986 8.11 6.77 2.5 Down 0.000 FLJ12118 7.68 8.51 1.8 Up 0.001 FLJ16008 5.56 6.24 1.6 Up 0.005 FLJ20273 RNA-binding protein | basigin (Ok blood group) 6.31 5.72 1.5 Down 0.004 FLJ20674 hypothetical protein FLJ20674 | hypothetical LOC653276 | similar5.31 to hypothetical5.96 protein1.6 FLJ20674Up | hypothetical0.007 protein BC001437 FLJ21963 FLJ21963 protein | hypothetical protein LOC51057 9.77 8.69 2.1 Down 0.001 FLJ31033 hypothetical protein FLJ31033 | hypothetical protein FLJ200356.97 5.58 2.6 Down 0.002 FLJ31951 hypothetical protein FLJ31951 | hypothetical gene supported by7.21 NM_1447268.24 | similar to2.0 Y119C1B.5Up 0.002 FLJ35348 5.49 6.04 1.5 Up 0.007 FN1 fibronectin 1 | gamma-glutamyltransferase 1 9.27 10.1 1.8 Up 0.006 FOXRED1 FAD-dependent domain containing 1 9.17 8.58 1.5 Down 0.010 FRAG1 FGF receptor activating protein 1 | chromosome 6 open reading8.3 frame 1677.52 | hypothetical1.7 LOC643189Down 0.001 FRK fyn-related kinase 8.57 7.46 2.2 Down 0.001 FRMD4A FERM domain containing 4A | hypothetical gene supported by 5.91AK126414 |6.47 RNA-binding1.5 region (RNP1,Up RRM) containing0.008 3 | cytochrome P450, family 20, subfamily A, polypeptide 1 FSD1 fibronectin type III and SPRY domain containing 1 | similar to 6.83fibronectin type7.46 III and SPRY1.5 domainUp containing0.005 1 FTSJ1 FtsJ homolog 1 (E. coli) 7.02 7.83 1.8 Up 0.003 FXYD5 FXYD domain containing ion transport regulator 5 5.95 6.56 1.5 Up 0.008 FZD1 frizzled homolog 1 (Drosophila) | hypothetical protein LOC6418356.74 | hypothetical7.44 LOC6457941.6 Up 0.005 FZD5 frizzled homolog 5 (Drosophila) 5.38 5.97 1.5 Up 0.007 FZD6 frizzled homolog 6 (Drosophila) 8.95 6.92 4.1 Down 0.000 G6PC3 glucose 6 phosphatase, catalytic, 3 8.76 8.05 1.6 Down 0.001 GADD45G growth arrest and DNA-damage-inducible, gamma 6.73 6.21 1.4 Down 0.009 GAL galanin 8.73 9.66 1.9 Up 0.001 GALNT14 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase5.89 6.72 141.8 (GalNAc-T14)Up 0.004 GDF11 growth differentiation factor 11 5.88 6.87 2.0 Up 0.001 GDI2 GDP dissociation inhibitor 2 | protein 208 | coiled-coil9.64 domain 10.43containing 1221.7 | hypotheticalUp protein0.005 FLJ38109 | neighbor of BRCA1 gene 2 | Pvt1 oncogene homolog, activator (mouse) | defender against cell death 1 | hypothetical protein DKFZp779O175 | ATG10 autophagy related 10 homolog (S. cerevisiae) | TBC1 domain family, member 7 | FLJ43329 protein | hypothetical LOC642313 GFRA1 GDNF family receptor alpha 1 | zinc finger, DHHC-type containing6.7 18 7.36 1.6 Up 0.009 GLI3 5.6 6.23 1.5 Up 0.008 GLO1 glyoxalase I 7.79 9.38 3.0 Up 0.000 GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting9.85 activity polypeptide8.18 3 3.2 Down 0.000 GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide5.37 6.29 1.9 Up 0.001 GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 8.23 8.86 1.5 Up 0.004 GNPDA1 glucosamine-6-phosphate deaminase 1 9.18 8.09 2.1 Down 0.006 GOLGA3 golgi autoantigen, golgin subfamily a, 3 | CHK1 checkpoint homolog7.55 (S. pombe)6.63 1.9 Down 0.000 GOLPH3L golgi phosphoprotein 3-like 9.01 8.06 1.9 Down 0.001 GOLT1B golgi transport 1 homolog B (S. cerevisiae) 9.33 8.34 2.0 Down 0.008 GPM6A glycoprotein M6A | mannose-P-dolichol utilization defect 1 7.4 6.4 2.0 Down 0.000 GPR124 G protein-coupled receptor 124 | hypothetical protein LOC7320137.62 | hypothetical8.5 protein1.8 LOC728168Up 0.007 GPR137B G protein-coupled receptor 137B 9.97 9.27 1.6 Down 0.002 GPR162 G protein-coupled receptor 162 5.73 6.55 1.8 Up 0.001 GPRC5A G protein-coupled receptor, family C, group 5, member A 6.64 5.76 1.8 Down 0.002 GPRC5B G protein-coupled receptor, family C, group 5, member B 7.66 8.5 1.8 Up 0.001 GRIK2 glutamate receptor, ionotropic, kainate 2 8.07 7.15 1.9 Down 0.000 GRP gastrin-releasing peptide 8.53 9.16 1.5 Up 0.008 GRPEL1 GrpE-like 1, mitochondrial (E. coli) | transcriptional adaptor 2 7.63(ADA2 homolog,8.34 yeast)-beta1.6 Up 0.005 GSC goosecoid 6.21 6.69 1.4 Up 0.010 GSN gelsolin (amyloidosis, Finnish type) 7.01 7.77 1.7 Up 0.004 GTF3A general transcription factor IIIA 7.5 8.38 1.8 Up 0.002 GTPBP2 GTP binding protein 2 8.03 7.35 1.6 Down 0.007 H1F0 H1 histone family, member 0 10.22 9.04 2.3 Down 0.000 HDAC7A 7A 5.94 6.54 1.5 Up 0.009 HDHD1A haloacid dehalogenase-like hydrolase domain containing 1A 9.02 8.29 1.7 Down 0.009 HELB helicase (DNA) B 7.32 6.64 1.6 Down 0.001 HERC6 hect domain and RLD 6 6.16 5.37 1.7 Down 0.004 HIATL1 abundant transcript-like 1 | hippocampus abundant8.55 gene transcript-like7.74 21.8 Down 0.008 HIP1 huntingtin interacting protein 1 5.82 6.76 1.9 Up 0.002 HIPK3 homeodomain interacting protein kinase 3 | CD5 molecule-like5.87 | RAB, member6.72 RAS oncogene1.8 family-likeUp 5 0.001 HIST1H4B histone cluster 1, H4b | histone cluster 2, H4a 7.62 8.29 1.6 Up 0.008 HIST1H4L histone cluster 1, H4l | histone cluster 1, H4k 7.97 9.03 2.1 Up 0.005 HK2 hexokinase 2 5.93 6.77 1.8 Up 0.004 HMGA1 high mobility group AT-hook 1 | ATPase, Ca++ transporting, cardiac7.69 muscle,8.49 slow twitch1.7 2 Up 0.004 HMGB2 high-mobility group box 2 9 9.76 1.7 Up 0.009 HMOX2 heme oxygenase (decycling) 2 | YEATS domain containing 4 8.87 7.81 2.1 Down 0.001 HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element 10.19RNA binding11.41 protein 1, 37kDa)2.3 Up 0.000 HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 | RANBP2-like7.12 and GRIP8.13 domain containing2.0 5 Up 0.000 HOXC11 homeobox C11 6.06 6.61 1.5 Up 0.005 HOXC9 homeobox C9 6.69 7.19 1.4 Up 0.009 HPS3 Hermansky-Pudlak syndrome 3 6.95 7.6 1.6 Up 0.008 HR hairless homolog (mouse) 6.84 7.56 1.6 Up 0.008 HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 7.67 8.35 1.6 Up 0.004 HSP90AA2 heat shock protein 90kDa alpha (cytosolic), class A member 211.37 | heat shock12.2 protein 90kDa1.8 alphaUp (cytosolic), class0.001 A member 1 HTATIP HIV-1 Tat interacting protein, 60kDa 5.98 6.9 1.9 Up 0.008 HUNK hormonally upregulated Neu-associated kinase 5.89 6.55 1.6 Up 0.005 HYAL2 hyaluronoglucosaminidase 2 | suppressor of variegation 4-20 homolog6.59 1 (Drosophila)7.27 1.6 Up 0.004 HYOU1 hypoxia up-regulated 1 8.53 9.28 1.7 Up 0.001 ICAM1 intercellular adhesion molecule 1 (CD54), rhinovirus receptor8.13 7.28 1.8 Down 0.001 ICAM2 intercellular adhesion molecule 2 7.12 6.12 2.0 Down 0.005 ICMT isoprenylcysteine carboxyl methyltransferase 8.5 9.36 1.8 Up 0.000 IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 8.62 9.67 2.1 Up 0.000 IFI35 interferon-induced protein 35 7.57 6.78 1.7 Down 0.000 IFI6 interferon, alpha-inducible protein 6 | similar to procollagen (type9.18 III) N-endopeptidase8.32 1.8 Down 0.002 IFIT1 interferon-induced protein with tetratricopeptide repeats 1 7.82 6.4 2.7 Down 0.004 IFIT2 interferon-induced protein with tetratricopeptide repeats 2 6.7 5.98 1.6 Down 0.003 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 7.69 6.48 2.3 Down 0.001 IFRD2 interferon-related developmental regulator 2 7.22 7.77 1.5 Up 0.008 IGSF9 immunoglobulin superfamily, member 9 6.03 6.82 1.7 Up 0.001 IL10RB interleukin 10 receptor, beta 6.1 6.89 1.7 Up 0.010 IL11RA interleukin 11 receptor, alpha 7.03 8.03 2.0 Up 0.001 IL1RAP interleukin 1 receptor accessory protein 10.55 9.95 1.5 Down 0.009 IL27RA interleukin 27 receptor, alpha 5.55 6.44 1.9 Up 0.001 IL32 interleukin 32 10.94 10.18 1.7 Down 0.006 IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor)6.55 | melanoma7.86 antigen family2.5 A, 4 Up 0.001 IL7R interleukin 7 receptor 6.45 5.72 1.7 Down 0.002 ILF3 interleukin enhancer binding factor 3, 90kDa 8.94 9.74 1.7 Up 0.001 IMPDH1 IMP (inosine monophosphate) dehydrogenase 1 8.35 8.99 1.6 Up 0.004 INA internexin neuronal intermediate filament protein, alpha 6.27 7.42 2.2 Up 0.005 INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa | tubulin,5.83 beta 6 |6.44 KIAA0174 1.5 Up 0.005 INPP5A inositol polyphosphate-5-phosphatase, 40kDa 7.31 8.17 1.8 Up 0.000 INPPL1 inositol polyphosphate phosphatase-like 1 | hypothetical protein6.95 LOC7295427.81 1.8 Up 0.002 INSIG1 insulin induced gene 1 7.72 6.69 2.0 Down 0.001 INSIG2 insulin induced gene 2 8.39 7.24 2.2 Down 0.002 INS-IGF2 insulin- insulin-like growth factor 2 | insulin-like growth factor 5.562 (somatomedin6.12 A) 1.5 Up 0.005 IPO11 importin 11 6.61 7.61 2.0 Up 0.002 IQGAP1 IQ motif containing GTPase activating protein 1 7.34 8.05 1.6 Up 0.002 IQSEC1 IQ motif and Sec7 domain 1 6.11 6.64 1.4 Up 0.006 IREB2 iron-responsive element binding protein 2 | CHK1 checkpoint homolog8.99 (S.8.12 pombe) 1.8 Down 0.003 IRS2 insulin receptor substrate 2 7.18 8.12 1.9 Up 0.004 ISG20L1 interferon stimulated exonuclease gene 20kDa-like 1 6.33 7.2 1.8 Up 0.000 ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa 7.98 6.72 2.4 Down 0.000 ISL1 6.96 6.48 1.4 Down 0.009 ISOC2 isochorismatase domain containing 2 6.64 7.4 1.7 Up 0.002 ITFG3 integrin alpha FG-GAP repeat containing 3 9.2 8.55 1.6 Down 0.006 ITGA1 integrin, alpha 1 | pelota homolog (Drosophila) | natural killer-tumor8.83 recognition7.95 sequence1.8 Down 0.010 ITGB5 integrin, beta 5 6.93 8.19 2.4 Up 0.000 ITPKA inositol 1,4,5-trisphosphate 3-kinase A 5.15 5.77 1.5 Up 0.005 IVD isovaleryl Coenzyme A dehydrogenase 8 7.36 1.6 Down 0.003 KATNAL1 katanin p60 subunit A-like 1 8.06 7.11 1.9 Down 0.005 KCNAB3 potassium voltage-gated channel, shaker-related subfamily, beta5.98 member6.77 3 1.7 Up 0.004 KCTD12 potassium channel tetramerisation domain containing 12 5.47 6.17 1.6 Up 0.004 KCTD15 potassium channel tetramerisation domain containing 15 5.46 6.29 1.8 Up 0.002 KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 | BCL2-like 13 (apoptosis7.53 facilitator)8.47 1.9 Up 0.004 KIAA0082 7.92 6.94 2.0 Down 0.001 KIAA0100 KIAA0100 | coiled-coil domain containing 134 7.14 8.16 2.0 Up 0.003 KIAA0265 8.81 7.89 1.9 Down 0.007 KIAA0408 KIAA0408 | chromosome 6 open reading frame 174 5.28 6.04 1.7 Up 0.006 KIAA0515 7.52 8.76 2.4 Up 0.002 KIAA0644 5.16 5.97 1.8 Up 0.006 KIAA1411 5.73 7.13 2.6 Up 0.000 KIAA1529 KIAA1529 | AE binding protein 1 5.67 6.41 1.7 Up 0.001 KIAA1804 mixed lineage kinase 4 5.56 6.43 1.8 Up 0.003 KIF11 kinesin family member 11 6.92 7.99 2.1 Up 0.002 KIF20A kinesin family member 20A 6.9 7.77 1.8 Up 0.002 KLF11 Kruppel-like factor 11 5.77 6.84 2.1 Up 0.000 KLF13 Kruppel-like factor 13 | chromosome 6 open reading frame 2176.96 | hypothetical7.68 protein LOC2837111.6 Up 0.001 KLHL12 kelch-like 12 (Drosophila) 7.98 7.37 1.5 Down 0.005 KLHL18 kelch-like 18 (Drosophila) 6.92 6.12 1.7 Down 0.008 KLHL24 kelch-like 24 (Drosophila) | YEATS domain containing 2 8.27 6.89 2.6 Down 0.000 KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 7.54 8.63 2.1 Up 0.002 KPNA1 karyopherin alpha 1 (importin alpha 5) 7.32 8.14 1.8 Up 0.010 KPNA5 karyopherin alpha 5 (importin alpha 6) 8.14 6.91 2.3 Down 0.000 KPNA6 karyopherin alpha 6 (importin alpha 7) 8.71 7.86 1.8 Down 0.003 LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) | hypothetical7.96 gene6.95 supported2.0 by AK126414Down 0.002 LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 6.18 6.88 1.6 Up 0.001 LARP6 La ribonucleoprotein domain family, member 6 7.17 7.65 1.4 Up 0.009 LASS1 LAG1 homolog, synthase 1 (S. cerevisiae) | growth differentiation5.62 6.27 factor 1 1.6 Up 0.005 LCP1 lymphocyte cytosolic protein 1 (L-plastin) 10.81 9.29 2.9 Down 0.000 LENG4 leukocyte receptor cluster (LRC) member 4 6.44 7 1.5 Up 0.005 LGP2 likely ortholog of mouse D11lgp2 | GCN5 general control of amino-acid6.8 synthesis5.95 5-like1.8 2 (yeast)Down 0.000 LGR5 leucine-rich repeat-containing G protein-coupled receptor 5 5.25 6.08 1.8 Up 0.001 LIN7C lin-7 homolog C (C. elegans) 8.47 6.85 3.1 Down 0.000 LIPH lipase, member H 5.78 5.09 1.6 Down 0.007 LIPI lipase, member I | hypothetical protein LOC650262 8.29 7.08 2.3 Down 0.003 LMNB2 lamin B2 7.84 8.42 1.5 Up 0.006 LOC162427 7.97 7.03 1.9 Down 0.001 LOC374395 similar to RIKEN cDNA 1810059G22 8.91 8.21 1.6 Down 0.006 LOC387882 hypothetical protein 7.14 8.15 2.0 Up 0.002 LOC400592 similar to Adenylosuccinate synthetase isozyme 2 (Adenylosuccinate9.78 synthetase,8.56 acidic2.3 isozyme)Down (IMP--aspartate0.000 2) (AdSS 2) (AMPSase 2) | adenylosuccinate synthase LOC441410 similar to FK506-binding protein 4 (Peptidyl-prolyl cis-trans )9.12 (PPIase)9.69 (Rotamase)1.5 (p59Up protein) (HSP-binding0.007 immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506-binding protein) (FKBP59) | FK506 binding protein 4, 59kDa LOC646604 similar to activating NK receptor precursor | U2AF homology motif8.82 (UHM) 7.69kinase 1 2.2 Down 0.000 LOC653691 FLJ40722-like | carbamoyl-phosphate synthetase 2, aspartate7.48 transcarbamylase,7.98 and dihydroorotase1.4 Up | Rho guanine0.009 nucleotide exchange factor (GEF) 5 | chromosome 2 open reading frame 28 LOC729193 hypothetical protein LOC729193 | hypothetical protein LOC7324606.3 | neuroligin7.28 4, X-linked2.0 | neuroliginUp 4, Y-linked0.002 LOC89944 hypothetical protein BC008326 7.11 7.92 1.8 Up 0.001 LOXHD1 lipoxygenase homology domains 1 | similar to lipoxygenase homology6.34 domains7.19 1 1.8 Up 0.005 LOXL1 lysyl oxidase-like 1 7.81 8.75 1.9 Up 0.004 LOXL2 lysyl oxidase-like 2 | ectonucleoside triphosphate diphosphohydrolase6.31 4 7.34 2.0 Up 0.000 LPP LIM domain containing preferred translocation partner in lipoma7.05 | chromosome6 12 open2.1 readingDown frame 9 | similar0.000 to CG10522-PA LPPR2 lipid phosphate phosphatase-related protein type 2 | hypothetical6.24 protein 6.83LOC126075 1.5 Up 0.004 LQK1 7 6.44 1.5 Down 0.008 LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 | E1A8.47 binding protein7.49 p300 2.0 Down 0.008 LRP1B low density lipoprotein-related protein 1B (deleted in tumors) 6.51 5.34 2.3 Down 0.000 LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein5.92 e receptor6.66 1.7 Up 0.002 LRRC17 leucine rich repeat containing 17 8 9 2.0 Up 0.005 LRRC37A leucine rich repeat containing 37A | acyl-Coenzyme A binding 8.19domain containing7.52 5 | leucine1.6 richDown repeat containing0.008 37, member A3 | hypothetical protein FLJ10120 | chromosome 17 open reading frame 13 LSM14A 7.79 9.46 3.2 Up 0.000 LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)6.65 | hypothetical7.61 protein 1.9LOC731486Up 0.001 LUZP1 protein 1 | amine oxidase (flavin containing) domain6.23 2 6.97 1.7 Up 0.003 M6PR mannose-6-phosphate receptor (cation dependent) 11.15 10.37 1.7 Down 0.002 MACF1 microtubule-actin crosslinking factor 1 | hypothetical LOC6433146.48 | basigin7.19 (Ok blood group)1.6 Up 0.007 MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 16.75 7.56 1.8 Up 0.005 MAP3K12 mitogen-activated protein kinase kinase kinase 12 5.42 6.05 1.5 Up 0.006 MAPK3 mitogen-activated protein kinase 3 6.87 8.36 2.8 Up 0.000 MAPK6 mitogen-activated protein kinase 6 8.89 8.02 1.8 Down 0.001 MCAM melanoma cell adhesion molecule 6.96 7.79 1.8 Up 0.001 MFAP4 microfibrillar-associated protein 4 9.33 10.04 1.6 Up 0.001 MFSD1 major facilitator superfamily domain containing 1 8.71 7.58 2.2 Down 0.005 MFSD2 major facilitator superfamily domain containing 2 | similar to ribosomal6.21 protein7.02 S2 1.8 Up 0.000 MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase7.45 8.12 1.6 Up 0.006 MIF4GD MIF4G domain containing 6.46 5.6 1.8 Down 0.003 MLC1 megalencephalic leukoencephalopathy with subcortical cysts 17.14 6.19 1.9 Down 0.001 MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog,6.81 Drosophila)7.62 | AF4/FMR21.8 family,Up member 1 |0.002 dehydrogenase E1 and transketolase domain containing 1 | succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2 | similar to AF4/FMR2 family member 1 (AF-4 protein) (Proto-oncogene AF4) (FEL protein) MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa6.46 type IV7.15 collagenase)1.6 Up 0.007 MOCS2 molybdenum synthesis 2 9.31 8.27 2.1 Down 0.001 MPP1 membrane protein, palmitoylated 1, 55kDa 6.44 7.52 2.1 Up 0.006 MPV17 MpV17 mitochondrial inner membrane protein 9.77 9.21 1.5 Down 0.008 MR1 major histocompatibility complex, class I-related 8.08 6.85 2.3 Down 0.000 MRGPRX3 MAS-related GPR, member X3 | family with sequence similarity6.85 122C 6.22 1.5 Down 0.004 M-RIP phosphatase-Rho interacting protein | S100P binding protein8.83 | chromosome9.36 171.4 open readingUp frame 840.009 | similar to myosin phosphatase-Rho interacting 2 MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)5.77 6.33 1.5 Up 0.004 MRPS35 mitochondrial ribosomal protein S35 8.04 8.84 1.7 Up 0.006 MRPS6 mitochondrial ribosomal protein S6 | solute carrier family 5 (inositol7.55 transporters),8.67 member2.2 3 Up 0.000 MSX2 | msh homeobox 2 pseudogene 6.6 7.49 1.9 Up 0.001 MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate6.66 cyclo-ligase)7.29 | similar1.5 to cervicalUp 0.005suppressor-1 MTMR1 myotubularin related protein 1 6.39 7.08 1.6 Up 0.006 MTMR14 myotubularin related protein 14 8.47 7.48 2.0 Down 0.002 MTMR6 myotubularin related protein 6 | hypothetical LOC646482 6.41 7.17 1.7 Up 0.004 MTP18 mitochondrial protein 18 kDa | SEC14-like 2 (S. cerevisiae) 6.06 6.83 1.7 Up 0.001 MTPN myotrophin 9.06 10.4 2.5 Up 0.000 MUTED muted homolog (mouse) | acyltransferase like 1 | thioredoxin 8.48domain containing9.34 5 1.8 Up 0.002 MVP major vault protein 6.82 6.03 1.7 Down 0.008 MYB v- myeloblastosis viral oncogene homolog (avian) 5.39 6.24 1.8 Up 0.007 MYBBP1A MYB binding protein (P160) 1a | hypothetical protein FLJ357857.96 8.47 1.4 Up 0.008 MYEF2 myelin expression factor 2 9.78 8.8 2.0 Down 0.004 N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) 7.61 6.95 1.6 Down 0.009 NAGK N-acetylglucosamine kinase 9.79 9.01 1.7 Down 0.002 NCLN nicalin homolog (zebrafish) | guanine nucleotide binding protein10.27 (G protein),11.24 beta polypeptide2.0 1 Up| NAD kinase0.000 NCOA5 coactivator 5 7.08 7.59 1.4 Up 0.008 NCOR2 nuclear receptor co-repressor 2 6.44 7 1.5 Up 0.009 NDN necdin homolog (mouse) 7.34 7.89 1.5 Up 0.006 NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa6.89 7.76 1.8 Up 0.006 NECAP1 NECAP endocytosis associated 1 8.67 7.5 2.3 Down 0.000 NEIL2 nei like 2 (E. coli) | family with sequence similarity 38, member6.2 A 6.74 1.5 Up 0.007 NELL2 NEL-like 2 (chicken) | similar to CG32662-PA 9.01 9.89 1.8 Up 0.001 NEO1 neogenin homolog 1 (chicken) 6.85 7.47 1.5 Up 0.002 NEU1 sialidase 1 (lysosomal sialidase) 9.55 8.58 2.0 Down 0.006 NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells9.44 2 (p49/p100)8.56 1.8 Down 0.000 NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells7.23 inhibitor,6.24 zeta 2.0 Down 0.001 NFYA nuclear transcription factor Y, alpha | hypothetical protein FLJ112366.98 | hypothetical7.91 gene1.9 supportedUp by AK1264140.004 | hypothetical LOC221442 NGLY1 N-glycanase 1 8.45 7.71 1.7 Down 0.007 NHLRC2 NHL repeat containing 2 7.23 6.39 1.8 Down 0.001 NID1 nidogen 1 7.15 9.04 3.7 Up 0.000 NIT1 1 8.27 7.37 1.9 Down 0.005 NKIRAS2 NFKB inhibitor interacting Ras-like 2 9.14 8.41 1.7 Down 0.004 NKX2-2 NK2 transcription factor related, 2 (Drosophila) 7.15 8.22 2.1 Up 0.001 NMNAT3 nicotinamide nucleotide adenylyltransferase 3 5.31 5.87 1.5 Up 0.008 NOG noggin 5.71 6.24 1.4 Up 0.010 NOL12 nucleolar protein 12 | TRIO and F-actin binding protein 7.33 7.82 1.4 Up 0.006 NOL4 nucleolar protein 4 | hypothetical protein LOC730852 | hypothetical7.01 protein6.39 LOC7300451.5 Down 0.005 NOPE likely ortholog of mouse neighbor of Punc E11 6.28 6.9 1.5 Up 0.005 NOTCH1 Notch homolog 1, translocation-associated (Drosophila) 5.71 6.49 1.7 Up 0.001 NOTCH3 Notch homolog 3 (Drosophila) 6.85 7.49 1.6 Up 0.003 NP nucleoside phosphorylase 7.21 7.79 1.5 Up 0.004 NPAL3 NIPA-like domain containing 3 8.49 7.36 2.2 Down 0.001 NPAS2 neuronal PAS domain protein 2 5.54 6.12 1.5 Up 0.009 NPTN neuroplastin 8.26 8.94 1.6 Up 0.002 NR2F2 nuclear receptor subfamily 2, group F, member 2 8.44 9.29 1.8 Up 0.001 NR4A1 nuclear receptor subfamily 4, group A, member 1 5.84 6.5 1.6 Up 0.003 NT5DC2 5'-nucleotidase domain containing 2 6.81 9.09 4.9 Up 0.000 NUDCD1 NudC domain containing 1 8.24 8.95 1.6 Up 0.007 NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 6.31 7.49 2.3 Up 0.001 NUP43 nucleoporin 43kDa 7.25 8.19 1.9 Up 0.007 NUP93 nucleoporin 93kDa 8.3 9.01 1.6 Up 0.007 NXPH4 neurexophilin 4 | serine hydroxymethyltransferase 2 (mitochondrial)5.53 6.07 1.5 Up 0.009 OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa | rabphilin 3A homolog6.81 (mouse)5.87 1.9 Down 0.005 OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa | 2'-5'-oligoadenylate7.39 synthetase6.85 2, 69/71kDa1.5 Down 0.009 OBSCN obscurin, cytoskeletal calmodulin and -interacting RhoGEF 6.25| DKFZP434C1536.7 protein1.4 | KIAA1639Up protein | 0.009similar to obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | glutathione S-transferase M5 OIP5 Opa interacting protein 5 7.65 8.32 1.6 Up 0.004 OLFM1 olfactomedin 1 5.7 6.34 1.6 Up 0.002 OLFML3 olfactomedin-like 3 8.39 9.48 2.1 Up 0.002 OPTN optineurin 8.19 7.35 1.8 Down 0.008 OSAP ovary-specific acidic protein 8.18 9.18 2.0 Up 0.003 OSBPL11 oxysterol binding protein-like 11 7.04 7.99 1.9 Up 0.001 OSBPL8 oxysterol binding protein-like 8 8.26 7.24 2.0 Down 0.002 OSGIN2 oxidative stress induced growth inhibitor family member 2 | hypothetical5.87 protein6.59 LOC7278871.6 | hypotheticalUp protein0.009 LOC730480 OTUD4 OTU domain containing 4 8.17 7.09 2.1 Down 0.001 OXNAD1 oxidoreductase NAD-binding domain containing 1 7.75 7.2 1.5 Down 0.006 P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5 5.8 6.51 1.6 Up 0.003 PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 8.43 7.26 2.3 Down 0.000 PAG1 phosphoprotein associated with glycosphingolipid microdomains7.72 1 6.61 2.2 Down 0.000 PANK1 pantothenate kinase 1 7.79 7.32 1.4 Down 0.007 PANK3 pantothenate kinase 3 | solute carrier family 2 (facilitated glucose6.73 transporter),7.72 member2.0 3 pseudogeneUp 1 0.001 PAPPA pregnancy-associated plasma protein A, pappalysin 1 | vacuolar6.37 protein sorting7.41 13 homolog2.1 D (S.Up cerevisiae)0.000 PARC -associated parkin-like cytoplasmic protein | KIAA1529 6.8 6.21 1.5 Down 0.004 PAWR PRKC, apoptosis, WT1, regulator 5.95 6.75 1.7 Up 0.003 PBXIP1 pre-B-cell leukemia transcription factor interacting protein 1 7.89 7.06 1.8 Down 0.001 PCBP4 poly(rC) binding protein 4 6.1 7.17 2.1 Up 0.001 PCGF1 polycomb group ring finger 1 | similar to polycomb group ring 7.41finger 1 8.16 1.7 Up 0.001 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain9.29 containing7.89 1 | hypothetical2.6 proteinDown LOC6520950.000 | hypothetical protein LOC647621 | hypothetical protein LOC649181 | hypothetical protein LOC649501 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain8.91 containing7.68 2 | hypothetical2.3 proteinDown LOC7292270.000 | hypothetical LOC400723 | similar to septin 8 | myelin transcription factor 1 | hypothetical protein LOC729055 | hypothetical protein LOC729754 | hypothetical protein LOC728462 | hypothetical protein LOC728496 | hypothetical LOC642263 | hypothetical protein LOC729891 PCQAP PC2 (positive cofactor 2, multiprotein complex) /Q-rich-associated6.16 7.33 protein | cytochrome2.3 Up P450, family0.000 20, subfamily A, polypeptide 1 PCSK6 proprotein convertase subtilisin/kexin type 6 5.46 6.36 1.9 Up 0.002 PCYT1A phosphate cytidylyltransferase 1, choline, alpha 8.57 8.09 1.4 Down 0.010 PDE1A phosphodiesterase 1A, calmodulin-dependent | isoleucine-tRNA8.46 synthetase7.46 2.0 Down 0.005 PDE1B phosphodiesterase 1B, calmodulin-dependent 6.42 7.64 2.3 Up 0.000 PDE4A phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce5.33 homolog,5.97 Drosophila)1.6 Up 0.004 PDE9A phosphodiesterase 9A 6.12 6.87 1.7 Up 0.002 PDGFA platelet-derived growth factor alpha polypeptide | synaptic vesicle6.7 glycoprotein7.54 2A 1.8 Up 0.003 PDGFC platelet derived growth factor C 7.16 7.96 1.7 Up 0.002 PEA15 phosphoprotein enriched in astrocytes 15 | glyceraldehyde-3-phosphate8.45 dehydrogenase9.09 1.6 Up 0.002 PEG10 paternally expressed 10 6.5 7.27 1.7 Up 0.004 PEX16 peroxisomal biogenesis factor 16 7.85 7.4 1.4 Down 0.010 PFTK1 PFTAIRE protein kinase 1 6.1 7.05 1.9 Up 0.003 PGAM5 phosphoglycerate mutase family member 5 | centaurin, gamma-like8 family,8.47 member 91.4 pseudogeneUp 0.009 PGM2L1 phosphoglucomutase 2-like 1 7.72 6.63 2.1 Down 0.009 PHKB phosphorylase kinase, beta 8.23 7.09 2.2 Down 0.001 PIAS2 protein inhibitor of activated STAT, 2 | similar to transcription elongation7.8 factor8.44 B polypeptide1.6 3CUp | transcription0.002 elongation factor B polypeptide 3C (elongin A3) PIGO phosphatidylinositol glycan anchor biosynthesis, class O | Fanconi6.73 anemia,6.23 complementation1.4 groupDown G 0.008 PIGS phosphatidylinositol glycan anchor biosynthesis, class S | polymerase8.26 (RNA)7.8 III (DNA directed)1.4 Down polypeptide H 0.008(22.9kD) PIGW phosphatidylinositol glycan anchor biosynthesis, class W 6.41 7.29 1.8 Up 0.004 PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide | similar8.52 to ATP synthase7.65 lipid-binding1.8 protein,Down mitochondrial0.001 precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) PIP5K2C phosphatidylinositol-4-phosphate 5-kinase, type II, gamma 9 8.37 1.5 Down 0.008 PITPNA phosphatidylinositol transfer protein, alpha | myosin IC 8.46 8.97 1.4 Up 0.006 PITX2 paired-like homeodomain transcription factor 2 8.43 7.75 1.6 Down 0.003 PJA2 praja 2, RING-H2 motif containing 7.19 8.39 2.3 Up 0.004 PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 6.53 7.07 1.5 Up 0.006 PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 7.03 7.74 1.6 Up 0.003 PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide7.87 binding6.88 specific) member2.0 1Down 0.000 PLOD1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 7.74 8.33 1.5 Up 0.009 PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 6.69 7.42 1.7 Up 0.002 PLSCR4 phospholipid scramblase 4 7.18 5.86 2.5 Down 0.000 PLTP phospholipid transfer protein | integrin, alpha V (vitronectin receptor,7.27 alpha7.9 polypeptide,1.5 antigenUp CD51) 0.006 PLXNA3 plexin A3 5.78 6.46 1.6 Up 0.004 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 8.1 8.98 1.8 Up 0.001 PODXL podocalyxin-like | CASP8 and FADD-like apoptosis regulator 5.45 6.2 1.7 Up 0.004 POLD3 polymerase (DNA-directed), delta 3, accessory subunit 7.18 7.85 1.6 Up 0.003 POLR1A polymerase (RNA) I polypeptide A, 194kDa | hypothetical protein6.76 LOC907847.8 2.1 Up 0.006 POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 7.6 8.5 1.9 Up 0.009 POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 7.03 7.87 1.8 Up 0.001 POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa9.07 9.66 1.5 Up 0.007 POLS polymerase (DNA directed) sigma 6.83 7.65 1.8 Up 0.006 PPAP2C phosphatidic acid phosphatase type 2C 5.84 6.48 1.6 Up 0.003 PPCS phosphopantothenoylcysteine synthetase 7.96 7.34 1.5 Down 0.004 PPIF peptidylprolyl isomerase F (cyclophilin F) 9.03 9.65 1.5 Up 0.006 PPM2C protein phosphatase 2C, magnesium-dependent, catalytic subunit6.47 7.33 1.8 Up 0.004 PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A | dermcidin8.52 9.29 1.7 Up 0.007 PPP3CA protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform8.45 (calcineurin7.85 A alpha)1.5 Down 0.009 PRC1 protein regulator of cytokinesis 1 | interferon-related developmental8.62 regulator9.92 1 2.5 Up 0.000 PRDM8 PR domain containing 8 5.82 6.63 1.8 Up 0.003 PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 5.89 6.46 1.5 Up 0.010 PRMT5 protein arginine methyltransferase 5 7.94 8.69 1.7 Up 0.003 PRPS2 phosphoribosyl pyrophosphate synthetase 2 7.62 8.49 1.8 Up 0.007 PRR6 proline rich 6 8.91 9.44 1.4 Up 0.005 PSMB9 (prosome, macropain) subunit, beta type, 9 (large9.44 multifunctional7.89 peptidase2.9 2) Down 0.000 PSMC3IP PSMC3 interacting protein 7.89 8.72 1.8 Up 0.000 PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 58.32 7.3 2.0 Down 0.003 PTCD2 pentatricopeptide repeat domain 2 8.94 8.13 1.8 Down 0.005 PTGFRN prostaglandin F2 receptor negative regulator | immunoglobulin7.51 superfamily,8.25 member 21.7 Up 0.003 PTP4A1 protein tyrosine phosphatase type IVA, member 1 | similar to 7.49protein tyrosine8.53 phosphatase2.1 4a1Up 0.000 PTP4A2 protein tyrosine phosphatase type IVA, member 2 8.75 9.34 1.5 Up 0.003 PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)7.39 8.16 1.7 Up 0.003 PTS 6-pyruvoyltetrahydropterin synthase 7.73 8.43 1.6 Up 0.010 PWWP2 PWWP domain containing 2 5.75 6.57 1.8 Up 0.009 PYGB phosphorylase, glycogen; brain 6.56 7.38 1.8 Up 0.000 QKI quaking homolog, KH domain RNA binding (mouse) 7.71 8.9 2.3 Up 0.000 RAB11FIP1 RAB11 family interacting protein 1 (class I) 7.09 7.77 1.6 Up 0.002 RAB15 5.61 6.31 1.6 Up 0.001 RAB26 6.52 7.25 1.7 Up 0.009 RAB8B 7.97 6.65 2.5 Down 0.001 RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP7.48 binding8.25 protein) 1.7 Up 0.003 RALGDS ral guanine nucleotide dissociation stimulator 6.19 7.13 1.9 Up 0.005 RAP2B 6.71 7.47 1.7 Up 0.008 RAP2C RAP2C, member of RAS oncogene family | similar to multiple substrate7.88 lipid7.38 kinase 1.4 Down 0.009 RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 8.75 8.05 1.6 Down 0.002 RARB , beta | similar to Retinoic acid receptor beta6.1 (RAR-beta)5.34 (RAR-epsilon)1.7 (HBV-activatedDown protein)0.009 RASA1 RAS p21 protein activator (GTPase activating protein) 1 8.19 7.38 1.8 Down 0.004 RASAL2 RAS protein activator like 2 5.66 6.32 1.6 Up 0.007 RASL10B RAS-like, family 10, member B 6.38 6.94 1.5 Up 0.003 RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 7.89 7.06 1.8 Down 0.004 RBM15B RNA binding motif protein 15B 6.07 6.87 1.7 Up 0.001 RBM24 RNA binding motif protein 24 5.29 7.05 3.4 Up 0.000 RBM38 RNA binding motif protein 38 5.91 6.65 1.7 Up 0.004 RBP1 retinol binding protein 1, cellular 7.64 8.51 1.8 Up 0.001 RBPMS2 RNA binding protein with multiple splicing 2 6.19 6.99 1.7 Up 0.002 RBPSUH recombining binding protein suppressor of hairless (Drosophila)6.81 | similar to7.87 Recombining2.1 bindingUp protein suppressor0.000 of hairless (J kappa-recombination signal binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (CBF-1) RCL1 RNA terminal phosphate cyclase-like 1 7.57 8.06 1.4 Up 0.006 RDX radixin | hypothetical gene FLJ14311 8.16 9.58 2.7 Up 0.000 RECQL4 RecQ protein-like 4 7.71 8.21 1.4 Up 0.007 RECQL5 RecQ protein-like 5 6.82 6.13 1.6 Down 0.005 REEP4 receptor accessory protein 4 8.72 9.35 1.5 Up 0.003 RGS19 regulator of G-protein signalling 19 6.5 6.96 1.4 Up 0.009 RGS4 regulator of G-protein signalling 4 5.96 6.78 1.8 Up 0.001 RHOBTB2 Rho-related BTB domain containing 2 5.7 6.57 1.8 Up 0.002 RIT1 Ras-like without CAAX 1 7.03 8.09 2.1 Up 0.000 RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)8.63 | BCL2-like7.87 13 (apoptosis1.7 facilitator)Down | hypothetical0.002 LOC645848 RND2 Rho family GTPase 2 | chromosome 21 open reading frame 9 6.64 7.4 1.7 Up 0.005 RNF122 ring finger protein 122 6.66 7.46 1.7 Up 0.001 RNF141 ring finger protein 141 9.27 8.31 1.9 Down 0.003 RNF168 ring finger protein 168 7.97 7.13 1.8 Down 0.006 ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian) | WAS protein6.34 homology7.13 region 1.72 domainUp containing 1-like0.005 1 | hypothetical protein LOC644873 | golgi associated PDZ and coiled-coil motif containing RP11-114G1.1 pseudogene | similar to ribosomal protein6.66 L5 7.91 2.4 Up 0.001 RP2 retinitis pigmentosa 2 (X-linked recessive) 7.77 8.62 1.8 Up 0.005 RPIA ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase)8.46 7.81 1.6 Down 0.004 RPS12 ribosomal protein S12 | hypothetical protein FLJ32312 | similar6.57 to ribosomal5.71 protein S121.8 Down 0.003 RPS19BP1 ribosomal protein S19 binding protein 1 7.78 8.42 1.6 Up 0.009 RRAGC Ras-related GTP binding C 9.25 8.48 1.7 Down 0.001 RSC1A1 regulatory solute carrier protein, family 1, member 1 | DDI1, DNA-damage7.65 6.63 inducible 1,2.0 homologDown 2 (S. cerevisiae)0.001 RSNL2 restin-like 2 7.8 6.72 2.1 Down 0.000 RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S.6.44 cerevisiae)7.47 2.0 Up 0.004 RUSC1 RUN and SH3 domain containing 1 | farnesyl diphosphate synthase6.45 (farnesyl7.29 pyrophosphate1.8 synthetase,Up dimethylallyltranstransferase,0.001 geranyltranstransferase) RUVBL2 RuvB-like 2 (E. coli) 8.52 9.49 2.0 Up 0.001 RXFP2 relaxin/insulin-like family peptide receptor 2 6.15 5.38 1.7 Down 0.003 RYK 7.27 8.3 2.0 Up 0.000 S100A10 S100 calcium binding protein A10 | similar to Keratin, type II cytoskeletal8.32 9.488 (Cytokeratin-8)2.2 (CK-8)Up (Keratin-8)0.008 (K8) S100PBP S100P binding protein 8.12 7.39 1.7 Down 0.001 SAMD1 sterile alpha motif domain containing 1 6.18 7.07 1.9 Up 0.001 SAR1B SAR1 gene homolog B (S. cerevisiae) 6.97 8.3 2.5 Up 0.000 SARM1 sterile alpha and TIR motif containing 1 5.89 6.69 1.7 Up 0.008 SBNO1 strawberry notch homolog 1 (Drosophila) | hypothetical protein8.11 LOC2833788.85 | similar to1.7 sno, strawberryUp notch0.001 homolog 1 (Drosophila) SCAMP1 secretory carrier membrane protein 1 7.1 8.27 2.3 Up 0.000 SCARB1 scavenger receptor class B, member 1 7.5 8.48 2.0 Up 0.000 SCD stearoyl-CoA desaturase (delta-9-desaturase) | similar to Acyl-CoA8.6 desaturase9.19 (Stearoyl-CoA1.5 desaturase)Up (Fatty0.007 acid desaturase) (Delta(9)-desaturase) SCD5 stearoyl-CoA desaturase 5 | similar to protein tyrosine phosphatase,6.68 non-receptor7.4 type1.6 11 | similarUp to Tyrosine-protein0.008 phosphatase non-receptor type 11 (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2) | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) SDC1 syndecan 1 5.91 6.9 2.0 Up 0.000 SEC24B SEC24 related , member B (S. cerevisiae) 6.61 7.87 2.4 Up 0.001 SEC63 7.7 8.91 2.3 Up 0.000 SELI selenoprotein I 7.5 8.48 2.0 Up 0.001 SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain,7.92 secreted,6.84 (semaphorin)2.1 3A Down 0.001 Sept5 septin 5 6.05 7.1 2.1 Up 0.002 SERINC1 serine incorporator 1 9.8 9.03 1.7 Down 0.009 SERINC3 serine incorporator 3 10.22 9.57 1.6 Down 0.010 SESN3 sestrin 3 8.96 7.69 2.4 Down 0.000 SF3B4 splicing factor 3b, subunit 4, 49kDa 8.05 8.59 1.5 Up 0.008 SGCZ zeta 6.56 5.64 1.9 Down 0.003 SGK serum/glucocorticoid regulated kinase 9.84 9.05 1.7 Down 0.006 SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing,7.12 alpha 8.52 2.6 Up 0.000 SH3BP5 SH3-domain binding protein 5 (BTK-associated) 5.69 6.32 1.5 Up 0.008 SH3PXD2A SH3 and PX domains 2A 6.98 7.67 1.6 Up 0.009 SHANK1 SH3 and multiple ankyrin repeat domains 1 6.1 6.62 1.4 Up 0.004 SHKBP1 SH3KBP1 binding protein 1 8.11 7.44 1.6 Down 0.009 SIDT2 SID1 transmembrane family, member 2 7.7 6.94 1.7 Down 0.003 SKP2 S-phase kinase-associated protein 2 (p45) | melanoma cell adhesion10.93 molecule10.1 | hypothetical1.8 proteinDown LOC7299380.002 | hypothetical protein LOC730779 SLC10A7 solute carrier family 10 (sodium/bile acid cotransporter family),7.69 member 7 6.9 1.7 Down 0.002 SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter8.85 1) 9.48 1.5 Up 0.002 SLC16A4 solute carrier family 16, member 4 (monocarboxylic acid transporter7.61 5) | 6.33ring finger protein2.4 141Down 0.002 SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate6.16 cotransporter),7.26 member2.1 7 Up 0.002 SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter),6.67 member 7.383 1.6 Up 0.008 SLC20A2 solute carrier family 20 (phosphate transporter), member 2 | cyclin-dependent7.79 7.22 kinase 1.56 Down 0.008 SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter),6.46 7.14 member 10 1.6 Up 0.009 SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 7.35 8.38 2.0 Up 0.000 SLC29A4 solute carrier family 29 (nucleoside transporters), member 4 |6.56 similar to solute7.12 carrier 1.5family 29Up (nucleoside transporters),0.007 member 4 SLC2A1 solute carrier family 2 (facilitated glucose transporter), member7.2 1 | similar7.72 to EVIN1 1.4 Up 0.004 SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 8.87 7.89 2.0 Down 0.005 SLC35E3 solute carrier family 35, member E3 8.55 7.8 1.7 Down 0.005 SLC37A4 solute carrier family 37 (glycerol-6-phosphate transporter), member8.18 4 8.77 1.5 Up 0.008 SLC39A14 solute carrier family 39 (zinc transporter), member 14 | catenin7.26 (cadherin-associated7.96 protein),1.6 betaUp 1, 88kDa0.001 SLC39A8 solute carrier family 39 (zinc transporter), member 8 7.3 6.62 1.6 Down 0.005 SLC41A1 solute carrier family 41, member 1 6.28 7.57 2.4 Up 0.000 SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member6.8 6 7.42| hypothetical1.5 protein UpLOC728721 0.005 SLC7A11 solute carrier family 7, (cationic transporter, y+ system)9.81 member8.59 11 2.3 Down 0.001 SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system),5.37 member6.23 3 | cancer/testis1.8 antigenUp CT45-30.002 SLC9A8 solute carrier family 9 (sodium/hydrogen exchanger), member7.58 8 6.69 1.9 Down 0.000 SLCO4A1 solute carrier organic anion transporter family, member 4A1 5.78 6.43 1.6 Up 0.005 SLFN5 schlafen family member 5 9.53 8.39 2.2 Down 0.000 SMAD6 SMAD family member 6 6.56 7.22 1.6 Up 0.002 SNORD41 small nucleolar RNA, C/D box 41 | transportin 2 (importin 3, karyopherin7.97 beta8.47 2b) 1.4 Up 0.006 SNORD62A small nucleolar RNA, C/D box 62A | small nucleolar RNA, C/D box7.26 62B | KIAA05158.42 2.2 Up 0.000 SNRK SNF related kinase 7.45 6.57 1.8 Down 0.002 SNX11 sorting nexin 11 8.46 7.85 1.5 Down 0.008 SNX27 sorting nexin family member 27 8.02 8.87 1.8 Up 0.000 SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase)9.3 18.42 | chromosome1.8 1 openDown reading frame0.001 125 SOCS4 suppressor of cytokine signaling 4 5.69 6.41 1.6 Up 0.007 SOX6 SRY (sex determining region Y)-box 6 8.39 6.98 2.7 Down 0.000 SP100 SP100 nuclear antigen | hypothetical protein BC004921 6.64 5.79 1.8 Down 0.003 SPAG5 sperm associated antigen 5 7.25 7.96 1.6 Up 0.007 SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)7.58 8.22 1.6 Up 0.005 SPRED2 sprouty-related, EVH1 domain containing 2 6.24 6.77 1.4 Up 0.005 SPRYD3 SPRY domain containing 3 8.5 7.38 2.2 Down 0.000 SPTBN2 spectrin, beta, non-erythrocytic 2 6.07 6.75 1.6 Up 0.009 SPTLC1 serine palmitoyltransferase, long chain base subunit 1 7.56 8.4 1.8 Up 0.004 SQSTM1 sequestosome 1 | similar to FKSG62 9.52 8.36 2.2 Down 0.000 SRD5A2L steroid 5 alpha-reductase 2-like 8 8.6 1.5 Up 0.009 SREBF1 sterol regulatory element binding transcription factor 1 5.92 6.82 1.9 Up 0.001 SRF (c-fos serum response element-binding6.36 transcription6.87 factor) 1.4 Up 0.007 SS18 synovial sarcoma translocation, chromosome 18 6.07 7.71 3.1 Up 0.001 SS18L1 synovial sarcoma translocation gene on chromosome 18-like 15.75 6.49 1.7 Up 0.001 STAT1 signal transducer and activator of transcription 1, 91kDa 9.25 8.67 1.5 Down 0.005 STAT6 signal transducer and activator of transcription 6, interleukin-4 9.5induced 8.83 1.6 Down 0.008 STEAP3 STEAP family member 3 5.81 6.87 2.1 Up 0.001 STK35 serine/ kinase 35 7.99 8.71 1.6 Up 0.001 STK38L serine/threonine kinase 38 like 9.19 8.28 1.9 Down 0.001 STRA6 stimulated by retinoic acid gene 6 homolog (mouse) 8.58 7.52 2.1 Down 0.001 STX2 syntaxin 2 7.07 8.35 2.4 Up 0.000 STX4 syntaxin 4 8.21 7.6 1.5 Down 0.004 STYXL1 serine/threonine/tyrosine interacting-like 1 7.59 6.82 1.7 Down 0.008 SUCLG1 succinate-CoA ligase, GDP-forming, alpha subunit 7.7 9.05 2.5 Up 0.000 TACC1 transforming, acidic coiled-coil containing protein 1 8.4 7.53 1.8 Down 0.008 TAF10 9.18 8.6 1.5 Down 0.008 TAIP-2 TGF-beta induced apoptosis protein 2 | hypothetical protein LOC7313408.35 7.05 2.5 Down 0.000 TAOK2 TAO kinase 2 6.57 7.37 1.7 Up 0.001 TARBP2 Tar (HIV-1) RNA binding protein 2 7.28 8.33 2.1 Up 0.000 TBC1D13 TBC1 domain family, member 13 7.39 6.51 1.8 Down 0.001 TBC1D16 TBC1 domain family, member 16 6.76 7.43 1.6 Up 0.010 TBC1D7 TBC1 domain family, member 7 | jumonji, AT rich interactive domain8.84 1B |7.85 cytochrome 2.0c oxidaseDown subunit VIIc0.004 TBCEL tubulin folding cofactor E-like 8.33 7.35 2.0 Down 0.010 TBX5 T-box 5 7.84 8.51 1.6 Up 0.009 TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors7.8 E12/E47)8.59 | catenin1.7 (cadherin-associatedUp 0.003 protein), delta 2 (neural plakophilin-related arm-repeat protein) TCFL5 transcription factor-like 5 (basic helix-loop-helix) 6.78 7.74 1.9 Up 0.005 TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal6.13 V0 subunit6.67 A3 1.5 Up 0.006 TCTA T-cell leukemia translocation altered gene 8.14 6.99 2.2 Down 0.000 TDG thymine-DNA glycosylase | similar to G/T mismatch-specific thymine8.11 DNA7.53 glycosylase |1.5 heat shockDown protein 90kDa0.004 beta (Grp94), member 1 TDO2 tryptophan 2,3-dioxygenase 6.16 8.5 5.1 Up 0.000 TDRKH tudor and KH domain containing 7.18 6.21 2.0 Down 0.002 TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)6.78 7.75 2.0 Up 0.001 TEX15 testis expressed sequence 15 6.45 7.36 1.9 Up 0.002 THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 6.4 7.66 2.4 Up 0.000 THRAP2 thyroid associated protein 2 | TL132 protein6.52 7.1 1.5 Up 0.008 THRAP5 associated protein 5 7.83 7.29 1.5 Down 0.009 THY1 Thy-1 cell surface antigen 7.1 8.76 3.2 Up 0.000 TIGD1 tigger transposable element derived 1 | NIMA (never in mitosis8.45 gene a)-related7.59 kinase 1.81 | threeDown prime histone0.006 mRNA exonuclease 1 TIMP2 TIMP metallopeptidase inhibitor 2 | similar to testis specific protein,8.37 Ddc8 8.96 1.5 Up 0.005 TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)8.74 9.5 1.7 Up 0.001 TIPARP TCDD-inducible poly(ADP-ribose) polymerase 7.97 8.68 1.6 Up 0.008 TLN1 talin 1 6.16 7.57 2.7 Up 0.000 TM7SF3 transmembrane 7 superfamily member 3 | sorting nexin 12 8.85 7.94 1.9 Down 0.006 TMBIM1 transmembrane BAX inhibitor motif containing 1 8.06 7.41 1.6 Down 0.002 TMED8 transmembrane emp24 protein transport domain containing 8 7.71| signal peptidase7.07 complex1.6 subunitDown 2 homolog 0.003(S. cerevisiae) TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains6.71 1 7.74 2.0 Up 0.002 TMEM127 transmembrane protein 127 7.63 7.11 1.4 Down 0.005 TMEM144 transmembrane protein 144 | hypothetical protein LOC2855058.41 7.27 2.2 Down 0.000 TMEM163 transmembrane protein 163 5.2 5.84 1.6 Up 0.006 TMEM164 transmembrane protein 164 8 7.4 1.5 Down 0.004 TMEM175 transmembrane protein 175 7.56 6.94 1.5 Down 0.008 TMEM41A transmembrane protein 41A 6.54 7.61 2.1 Up 0.000 TMEM50B transmembrane protein 50B | deltex homolog 2 (Drosophila) 6.47 7.65 2.3 Up 0.001 TMEM51 transmembrane protein 51 5.67 6.49 1.8 Up 0.003 TMEM54 transmembrane protein 54 7.01 7.88 1.8 Up 0.001 TMEM63A transmembrane protein 63A | hypothetical protein LOC7287966.79 | hypothetical6.02 protein LOC7311051.7 Down 0.007 TMEM66 transmembrane protein 66 10.19 9.54 1.6 Down 0.006 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 7.76 6.76 2.0 Down 0.002 TNFAIP6 tumor necrosis factor, alpha-induced protein 6 9.18 10.33 2.2 Up 0.000 TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy6.71 with truncated7.67 death domain1.9 Up 0.000 TNFRSF9 tumor necrosis factor receptor superfamily, member 9 9.32 8.53 1.7 Down 0.007 TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 5.43 6.55 2.2 Up 0.001 TNRC6A trinucleotide repeat containing 6A 7.04 8.1 2.1 Up 0.000 TOMM34 of outer mitochondrial membrane 34 7.34 8.29 1.9 Up 0.001 TOP1MT topoisomerase (DNA) I, mitochondrial | hypothetical protein LOC7307836.51 | hypothetical8.4 3.7 protein LOC732473Up 0.000 TOP1P1 topoisomerase (DNA) I pseudogene 1 | flavin containing monooxygenase7.08 5.874 2.3 Down 0.000 TOR1B torsin family 1, member B (torsin B) 7.99 7.01 2.0 Down 0.005 TP53I11 tumor protein p53 inducible protein 11 | tetraspanin 18 6.42 6.98 1.5 Up 0.007 TPM1 1 (alpha) 7.07 7.69 1.5 Up 0.006 TPM2 tropomyosin 2 (beta) | peptidylprolyl isomerase (cyclophilin)-like6.87 5 7.4 1.4 Up 0.009 TPM3 tropomyosin 3 | chromosome 15 open reading frame 41 | ATPase,7.4 Class I,6.64 type 8B, member1.7 3Down | tropomyosin0.008 3 pseudogene | similar to tropomyosin 3 isoform 2 | La ribonucleoprotein domain family, member 4 | similar to c-Mpl binding protein isoform c TPP1 tripeptidyl peptidase I 8.18 7.34 1.8 Down 0.002 TRAM2 translocation associated membrane protein 2 5.35 6.12 1.7 Up 0.010 TRIAP1 TP53 regulated inhibitor of apoptosis 1 8.38 9.01 1.5 Up 0.004 TRIB2 tribbles homolog 2 (Drosophila) 6.42 7.2 1.7 Up 0.001 TRIM3 tripartite motif-containing 3 6.35 6.91 1.5 Up 0.004 TROVE2 TROVE domain family, member 2 | hypothetical protein LOC2861919.68 8.52 2.2 Down 0.000 TRPV4 transient receptor potential cation channel, subfamily V, member5.39 4 | similar5.99 to Glycolipid1.5 transferUp protein (GLTP)0.009 | glycolipid transfer protein TSPAN31 tetraspanin 31 9.83 8.4 2.7 Down 0.000 TSPAN7 tetraspanin 7 6.49 7.36 1.8 Up 0.005 TSPYL5 TSPY-like 5 7.66 6.99 1.6 Down 0.006 TUB tubby homolog (mouse) 5.72 6.32 1.5 Up 0.007 TUBB2A tubulin, beta 2A | tubulin, beta 6 6.14 7.24 2.1 Up 0.000 TUBB2B tubulin, beta 2B | tubulin, beta 6 7.13 8.84 3.3 Up 0.000 TUBB4 tubulin, beta 4 6.19 7.22 2.0 Up 0.000 TUBB6 tubulin, beta 6 | gamma-glutamyltransferase 1 7.29 8.03 1.7 Up 0.001 TYSND1 trypsin domain containing 1 7.13 7.91 1.7 Up 0.009 UBE2Q2 ubiquitin-conjugating enzyme E2Q (putative) 2 | similar to ubiquitin-conjugating6 6.69 enzyme1.6 E2Q 2Up 0.005 UBE4B ubiquitination factor E4B (UFD2 homolog, yeast) 9.56 8.95 1.5 Down 0.006 UBL4A ubiquitin-like 4A 5.87 6.67 1.7 Up 0.003 UBTF upstream binding transcription factor, RNA polymerase I 7.12 8.35 2.3 Up 0.005 UCK1 uridine-cytidine kinase 1 7.6 8.67 2.1 Up 0.001 UCKL1 uridine-cytidine kinase 1-like 1 6.17 7.06 1.9 Up 0.004 UGCG UDP-glucose ceramide glucosyltransferase 6.48 7.16 1.6 Up 0.010 UGP2 UDP-glucose pyrophosphorylase 2 7 7.81 1.8 Up 0.009 ULK1 unc-51-like kinase 1 (C. elegans) 6.38 7.23 1.8 Up 0.004 UNC84B unc-84 homolog B (C. elegans) 8.29 7.51 1.7 Down 0.001 UNG uracil-DNA glycosylase 7.89 8.56 1.6 Up 0.007 UNKL unkempt-like (Drosophila) | chromosome 16 open reading frame7.31 28 6.67 1.6 Down 0.003 UNQ1887 signal peptide peptidase 3 | solute carrier family 7 (cationic amino6.68 acid transporter,8.13 y+2.7 system),Up member 2 0.000 URG4 up-regulated gene 4 | cytochrome P450, family 20, subfamily 5.27A, polypeptide5.9 1 1.5 Up 0.007 UROS uroporphyrinogen III synthase (congenital erythropoietic porphyria)9.94 9.1 1.8 Down 0.003 USP31 ubiquitin specific peptidase 31 5.72 6.49 1.7 Up 0.001 USP39 ubiquitin specific peptidase 39 8.71 9.49 1.7 Up 0.001 USP52 ubiquitin specific peptidase 52 | citrate synthase | transmembrane8.43 protein7.13 4 2.5 Down 0.000 UXS1 UDP-glucuronate decarboxylase 1 7.34 8.28 1.9 Up 0.001 VEZT vezatin, adherens junctions transmembrane protein 8.57 7.11 2.8 Down 0.000 VPS36 vacuolar protein sorting 36 homolog (yeast) 8.5 7.94 1.5 Down 0.004 VWCE von Willebrand factor C and EGF domains 5.52 6.26 1.7 Up 0.004 WASF1 WAS , member 1 7.81 9.18 2.6 Up 0.000 WBSCR17 Williams-Beuren syndrome chromosome region 17 | limb bud 7.73and development9.51 homolog3.4 (mouse)Up 0.000 WDFY1 WD repeat and FYVE domain containing 1 8.23 8.84 1.5 Up 0.005 WDR40A WD repeat domain 40A | hypothetical protein LOC340184 7.93 7.2 1.7 Down 0.001 WDR71 WD repeat domain 71 7.89 7.03 1.8 Down 0.009 WDR90 WD repeat domain 90 6.23 7.1 1.8 Up 0.005 WEE1 WEE1 homolog (S. pombe) | similar to WEE1 homolog (S. pombe)9.31 8.47 1.8 Down 0.002 WNT10A wingless-type MMTV integration site family, member 10A 6.66 6.03 1.5 Down 0.003 WNT5A wingless-type MMTV integration site family, member 5A 6.97 7.81 1.8 Up 0.002 WWC3 WWC family member 3 | hypothetical protein LOC340184 | hypothetical6 protein7.08 LOC7293612.1 | hypotheticalUp protein0.000 LOC732464 XAB1 XPA binding protein 1, GTPase 7.24 8.15 1.9 Up 0.003 XPR1 xenotropic and polytropic receptor | KIAA1614 7.85 8.8 1.9 Up 0.001 XYLT2 xylosyltransferase II 5.92 6.64 1.6 Up 0.005 YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 7.36 8.4 2.1 Up 0.001 YIPF4 Yip1 domain family, member 4 9.44 8.71 1.7 Down 0.001 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation7.64 protein,9.48 eta polypeptide3.6 Up 0.000 ZBED4 zinc finger, BED-type containing 4 6.92 7.71 1.7 Up 0.001 ZBTB41 zinc finger and BTB domain containing 41 7.93 6.26 3.2 Down 0.000 ZDHHC12 zinc finger, DHHC-type containing 12 8.6 7.76 1.8 Down 0.002 ZDHHC20 zinc finger, DHHC-type containing 20 | hypothetical protein LOC7280996.95 8.36 2.7 Up 0.000 ZDHHC20 zinc finger, DHHC-type containing 20 6.08 7.33 2.4 Up 0.000 ZDHHC4 zinc finger, DHHC-type containing 4 9.34 8.61 1.7 Down 0.004 ZFAND6 zinc finger, AN1-type domain 6 8 8.46 1.4 Up 0.009 ZFYVE1 zinc finger, FYVE domain containing 1 6.78 5.94 1.8 Down 0.004 ZFYVE26 zinc finger, FYVE domain containing 26 6.97 6.28 1.6 Down 0.005 ZFYVE9 zinc finger, FYVE domain containing 9 | similar to Zinc finger FYVE5.34 domain-containing6.12 protein1.7 9 Up(Mothers against0.008 decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP... | phosducin-like 3 pseudogene | similar to Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) ZIC2 Zic family member 2 (odd-paired homolog, Drosophila) 6.82 7.54 1.6 Up 0.003 ZMYND19 zinc finger, MYND-type containing 19 6.92 7.47 1.5 Up 0.008 ZNF146 zinc finger protein 146 | zinc finger protein 268 | hypothetical 7.32protein DKFZp779O1757.99 1.6| X-ray repairUp complementing0.007 defective repair in Chinese hamster cells 2 | KIAA0220-like protein ZNF367 zinc finger protein 367 | hypothetical protein LOC728508 | hypothetical5.79 protein6.29 LOC7317231.4 Up 0.008 ZNF584 zinc finger protein 584 6.13 6.96 1.8 Up 0.002 ZNF92 zinc finger protein 92 | zinc finger protein 208 | similar to zinc6.58 finger protein7.19 91 1.5 Up 0.008 ZYX zyxin 6.95 7.95 2.0 Up 0.000 Supplementary Table 1B. OVERLAP WITH DAOY CELLS (Wiederschain et al): 101 Commonly Regulated Genes following BMI-1 Knockdown genesymbol genedescription Dir ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 Up ALDH1A3 aldehyde dehydrogenase 1 family, member A3 Up API5 apoptosis inhibitor 5 Down ARL1 ADP-ribosylation factor-like 1 Down ADP-ribosylation factor-like 5B | similar to Programmed cell death protein 8, mitochondrial precursor (Apoptosis-inducing ARL5B Down factor) ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae) | ATP-binding cassette, sub-family B (MDR/TAP), member 6 Up ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A Down BGN biglycan Up BMI1 B lymphoma Mo-MLV insertion region (mouse) | COMM domain containing 3 Down BMP7 bone morphogenetic protein 7 (osteogenic protein 1) Up C1orf75 chromosome 1 open reading frame 75 Up C20orf77 chromosome 20 open reading frame 77 Down C21orf6 chromosome 21 open reading frame 6 | BTB (POZ) domain containing 5 Down C4orf34 chromosome 4 open reading frame 34 Down CBR4 carbonyl reductase 4 Down CCNG2 cyclin G2 Down COG5 component of oligomeric golgi complex 5 Down COL4A1 collagen, type IV, alpha 1 Up COL4A2 collagen, type IV, alpha 2 Up COL5A1 collagen, type V, alpha 1 Up COL6A1 collagen, type VI, alpha 1 Up COL6A2 collagen, type VI, alpha 2 Up CPEB4 cytoplasmic polyadenylation element binding protein 4 Down CREBL2 cAMP responsive element binding protein-like 2 Down DCBLD2 discoidin, CUB and LCCL domain containing 2 Up DCP2 Down DKK3 dickkopf homolog 3 (Xenopus laevis) Up EGFR-coamplified and overexpressed protein | similar to EGFR-coamplified and overexpressed protein | hypothetical protein ECOP Up LOC729086 ETNK1 ethanolamine kinase 1 Down F2R coagulation factor II (thrombin) receptor Up FAM57A family with sequence similarity 57, member A Up FLJ20273 RNA-binding protein | basigin (Ok blood group) Down FLJ21963 FLJ21963 protein | hypothetical protein LOC51057 Down FLJ31033 hypothetical protein FLJ31033 | hypothetical protein FLJ20035 Down FRK fyn-related kinase Down FXYD5 FXYD domain containing ion transport regulator 5 Up GAL galanin Up GALNT14 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) Up GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 Down HDHD1A haloacid dehalogenase-like hydrolase domain containing 1A Down HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) Up HYOU1 hypoxia up-regulated 1 Up IREB2 iron-responsive element binding protein 2 | CHK1 checkpoint homolog (S. pombe) Down KIAA0408 KIAA0408 | chromosome 6 open reading frame 174 Up KLF11 Kruppel-like factor 11 Up LIN7C lin-7 homolog C (C. elegans) Down LOC646604 similar to activating NK receptor precursor | U2AF homology motif (UHM) kinase 1 Down LOXL2 lysyl oxidase-like 2 | ectonucleoside triphosphate diphosphohydrolase 4 Up LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Up LRRC17 leucine rich repeat containing 17 Up leucine rich repeat containing 37A | acyl-Coenzyme A binding domain containing 5 | leucine rich repeat containing 37, LRRC37A Down member A3 | hypothetical protein FLJ10120 | chromosome 17 open reading frame 13 LUZP1 leucine zipper protein 1 | amine oxidase (flavin containing) domain 2 Up MACF1 microtubule-actin crosslinking factor 1 | hypothetical LOC643314 | basigin (Ok blood group) Up MAPK6 mitogen-activated protein kinase 6 Down MCAM melanoma cell adhesion molecule Up MFAP4 microfibrillar-associated protein 4 Up MVP major vault protein Down MYEF2 myelin expression factor 2 Down N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) Down NCOR2 nuclear receptor co-repressor 2 Up NID1 nidogen 1 Up NOTCH1 Notch homolog 1, translocation-associated (Drosophila) Up OTUD4 OTU domain containing 4 Down PAPPA pregnancy-associated plasma protein A, pappalysin 1 | vacuolar protein sorting 13 homolog D (S. cerevisiae) Up PAWR PRKC, apoptosis, WT1, regulator Up PHKB phosphorylase kinase, beta Down PODXL podocalyxin-like | CASP8 and FADD-like apoptosis regulator Up PPAP2C phosphatidic acid phosphatase type 2C Up PPP3CA protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) Down PTCD2 pentatricopeptide repeat domain 2 Down PTGFRN prostaglandin F2 receptor negative regulator | immunoglobulin superfamily, member 2 Up RAB8B Down RNF141 ring finger protein 141 Down RSC1A1 regulatory solute carrier protein, family 1, member 1 | DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae) Down S100PBP S100P binding protein Down SCARB1 scavenger receptor class B, member 1 Up SDC1 syndecan 1 Up SELI selenoprotein I Up SESN3 sestrin 3 Down SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 Up SLC39A14 solute carrier family 39 (zinc transporter), member 14 | catenin (cadherin-associated protein), beta 1, 88kDa Up SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 Down SLCO4A1 solute carrier organic anion transporter family, member 4A1 Up SLFN5 schlafen family member 5 Down STEAP3 STEAP family member 3 Up transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) | catenin (cadherin-associated protein), delta TCF3 Up 2 (neural plakophilin-related arm-repeat protein) tigger transposable element derived 1 | NIMA (never in mitosis gene a)-related kinase 1 | three prime histone mRNA TIGD1 Down exonuclease 1 TIMP2 TIMP metallopeptidase inhibitor 2 | similar to testis specific protein, Ddc8 Up TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) Up TMED8 transmembrane emp24 protein transport domain containing 8 | signal peptidase complex subunit 2 homolog (S. cerevisiae) Down TMEM41A transmembrane protein 41A Up TMEM51 transmembrane protein 51 Up TNFAIP6 tumor necrosis factor, alpha-induced protein 6 Up TPM1 tropomyosin 1 (alpha) Up TRAM2 translocation associated membrane protein 2 Up TROVE2 TROVE domain family, member 2 | hypothetical protein LOC286191 Down UGCG UDP-glucose ceramide glucosyltransferase Up UXS1 UDP-glucuronate decarboxylase 1 Up VEZT vezatin, adherens junctions transmembrane protein Down WNT5A wingless-type MMTV integration site family, member 5A Up ZBTB41 zinc finger and BTB domain containing 41 Down