Lecture 2 – Bone
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Comparison of Etoricoxib and Indomethacin for the Treatment of Experimental Periodontitis in Rats
Brazilian Journal of Medical and Biological Research (2007) 40: 117-125 Etoricoxib in experimental periodontitis 117 ISSN 0100-879X Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats M.C.F. Azoubel1, 1Departamento de Fisiologia e Farmacologia, A.M.A. Menezes1, 2Departamento de Morfologia, Faculdade de Medicina, D. Bezerra1, R.B. Oriá2, Universidade Federal do Ceará, Fortaleza, CE, Brasil R.A. Ribeiro1 and G.A.C. Brito2 Abstract Correspondence We investigated the effect of etoricoxib, a selective cyclooxygenase- Key words G.A.C. Brito 2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhib- • Alveolar bone loss Departamento de Fisiologia itor, on experimental periodontitis, and compared their gastrointesti- • Inflammation e Farmacologia nal side effects. A ligature was placed around the second upper left • Periodontitis Faculdade de Medicina, UFC molars of female Wistar rats (160 to 200 g). Animals (6 per group) • Cyclooxygenase inhibitors Rua Coronel Nunes de Melo, 1127 • were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg Etoricoxib 60430-270 Fortaleza, CE • Indomethacin Brasil indomethacin, or 0.2 mL saline, starting 5 days after the induction of Fax: +55-85-3366-8333 periodontitis, when bone resorption was detected, until the sacrifice E-mail: [email protected] on the 11th day. The weight and survival rate were monitored. Alveolar bone loss (ABL) was measured as the sum of distances Research supported by CNPq and between the cusp tips and the alveolar bone. The gastric mucosa was Fundação Cearense de Pesquisa e examined macroscopically and the periodontium and gastric and Cultura (FUNCAP). -
Ono -- PTH-Pthrp Receptor Signaling in Osterix-Expressing Progenitors.Pdf
3/27/14 Root forma)on Cementum Dentin Cementoblast Odontoblast Role of PTH/PTHrP Receptor Signaling on Root Epithelial rests Formaon of Malassez (ERM) Dental Wanida Ono papilla cells AGE Orthodon;cs, Department of Developmental Biology, Harvard School of Dental Medicine Endocrine Unit, MassachuseLs General Hospital and Harvard Medical School Dental follicle cells Hertwig’s epithelial root sheath (HERS) Osterix PTHrP-PPR system • Transcripon factor essen;al to osteoblast differen;aon PTHrP (Nakashima K et al. 2002) PTH/PTHrP receptor (PPR) • Expressed in odontoblasts and alveolar osteoblasts during Gαs Gq tooth development (Chen S et al. 2009) • Controls cellular cementum formaon (Cao Z et al. 2012) • Mediates epithelial-mesenchymal interacons • Osterix-expressing precursors in the perichondrium move • PTHrP is expressed in enamel epithelia/HERS? to bone marrow and become osteoblasts during fetal • PPR is expressed in dental mesenchymes development (Maes C, Kronenberg HM et al. 2010) (Beck et al 1995; Lee Deeds and Segre 1995; Liu et al 1998) • PTHrP is required for tooth erup;on in mice (Philbrick WM, Karaplis AC et al. PNAS 1998) Osterix+ Root-forming • PPR haploinsufficiency is associated with primary cells progenitors failure of tooth erup;on (PFE) in humans ? (Decker E, Weber BH et al. Am J Hum Gen 2008) PTHrP expression paern during root morphogenesis Aims of this study PTHrPLacZ/+ x40 P7 P14 P49 • Iden;fy how osterix-expressing progenitors contribute to murine root morphogenesis • Understand how PTH/PTHrP receptor signal regulates root-forming progenitors PTHrP-LacZ x200 P7 x400 P14 ? PTHrP Epithelial root sheath PPR PTHrP-LacZ Osx+ progenitors Odontoblast PTHrP par;cipates in ……. -
Selecting Different Approaches for Palate and Pharynx Surgery
SPECIAL ISSUE 4: INVITED ARTICLE Selecting Different Approaches for Palate and Pharynx Surgery: Palatopharyngeal Arch Staging System Rodolfo Lugo-Saldaña1 , Karina Saldívar-Ponce2 , Irina González-Sáez3 , Daniela Hernández-Sirit4 , Patricia Mireles-García5 ABSTRACT The examination of the anatomical structures involved in the upper airway collapse in patients with the obstructive sleep apnea-hypopnea syndrome (OSAHS) is a key for integrated evaluation of patients. Our proposal is for a noninvasive classification system that guides us about the presence of anatomical differences between the palatopharyngeal muscle (PFM). The functions of the PFM are narrowing the isthmus, descending the palate, and raising the larynx during swallowing; these characteristics give the PFM a special role in the collapse of the lateral pharyngeal wall. Complete knowledge of the anatomy and classification of different variants can guide us to choose the appropriate surgical procedures for the lateral wall collapse. Until now there is not a consensus about description of the trajectory or anatomical variants of the PFM into oropharynx, the distance between both muscles, and the muscle tone. Here we also present the relationship between the lateral wall surgeries currently available (lateral pharyngoplasty by Cahali, expansion sphincteroplasty by Pang, relocation pharyngoplasty by Li, Roman blinds pharyngoplasty by Mantovani, and barbed sutures pharyngoplasty by Vicini) with the proposed classification of the palatopharyngeal arch staging system (PASS). Keywords: -
Alveolar Ridge Preservation at Different Anatomical Locations
ALVEOLAR RIDGE PRESERVATION AT DIFFERENT ANATOMICAL LOCATIONS- CLINICAL AND HISTOLOGICAL EVALUATION OF TREATMENT OUTCOME MASTERS THESIS Presented in Partial Fulfillment of Requirements for the Degree Master of Science in Dentistry in the Graduate School of The Ohio State University By Mabel Salas, DDS Graduate Program in Dentistry The Ohio State University 2009 Master’s Examination Committee: Binnaz Leblebicioglu, DDS, MS, PhD, Advisor Dimitris N. Tatakis, DDS, PhD Suda Agarwal, PhD Do-Gyoon Kim, PhD Copyright by Mabel Salas 2009 ABSTRACT Background: Alveolar ridge preservation (ARP) is a surgical technique designed to prevent naturally occurring post-extraction bone resorption. It is well documented that alveolar bone height and width are reduced following tooth extraction as a result of physiologic bone remodeling. Depending on the type of post-extraction intrabony defect, an immediate or early implant placement itself may preserve the bone height and width. However, if the defect is generally too wide for immediate and/or early implant placement, it is recommended to perform ARP surgery to preserve the bone volume for future implant placement. The purpose of this study was to investigate clinical and histological healing outcomes following ARP performed on molar and premolar sites by using freeze-dried bone allograft (FDBA) together with a collagen membrane. Maxillary and mandibular sextants were compared for clinical and histological parameters. Methods: Patients who were scheduled to have tooth extraction and implant placement for a molar or premolar tooth were included into this study. Inclusion criteria were single tooth extraction with intact mesial and distal adjacent teeth. Exclusion criteria were smokers, systemic health problems that may affect wound healing and acute infection ii that may prevent bone graft placement. -
Journal of Dental Research
Journal of Dental Research http://jdr.sagepub.com/ Cell Differentiation and Matrix Organization in Engineered Teeth A. Nait Lechguer, M.L. Couble, N. Labert, S. Kuchler-Bopp, L. Keller, H. Magloire, F. Bleicher and H. Lesot J DENT RES 2011 90: 583 originally published online 4 February 2011 DOI: 10.1177/0022034510391796 The online version of this article can be found at: http://jdr.sagepub.com/content/90/5/583 Published by: http://www.sagepublications.com On behalf of: International and American Associations for Dental Research Additional services and information for Journal of Dental Research can be found at: Email Alerts: http://jdr.sagepub.com/cgi/alerts Subscriptions: http://jdr.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav >> Version of Record - Apr 13, 2011 OnlineFirst Version of Record - Feb 4, 2011 What is This? Downloaded from jdr.sagepub.com at Service Commun de la Documentation Université de Strasbourg on September 6, 2013 For personal use only. No other uses without permission. © 2011 International & American Associations for Dental Research RESEARCH REPORTS Biomaterials & Bioengineering A. Nait Lechguer1,2, M.L. Couble3,4, N. Labert3,4, S. Kuchler-Bopp1,2, Cell Differentiation and L. Keller1,2, H. Magloire3,4, F. Bleicher3,4, Matrix Organization in and H. Lesot1,2* Engineered Teeth 1INSERM UMR 977, Faculté de Médecine, 11, rue Humann, F-67085 Strasbourg, France; 2Dental School, University of Strasbourg, Strasbourg, France; 3Université de Lyon, Faculté d’Odontologie, Rue Guillaume Paradin, F-69372 Lyon Cedex 08, France; and 4IGFL, CNRS UMR 5242, Ecole Normale Supérieure, 46 Allée d’Italie, 69364, Lyon Cedex 08, France; *corresponding author, [email protected] J Dent Res 90(5):583-589, 2011 ABSTRACT InTRODuCTIOn Embryonic dental cells were used to check a series of criteria to be achieved for tooth engineering. -
Benign Cementoblastoma Associated with an Unerupted Third Molar - a Case Report
CORE Metadata, citation and similar papers at core.ac.uk Provided by Directory of Open Access Journals BENIGN CEMENTOBLASTOMA ASSOCIATED WITH AN UNERUPTED THIRD MOLAR - A CASE REPORT J.Dinakar* M.S.Senthil Kumar** Shiju Mathew Jacob*** *Professor & HOD, Department of Oral Pathology, ** Reader, *** Lecturer, Department of Oral Surgery, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamilnadu, India. ABSTRACT: Cementoblastoma is a rare odontogenic tumor derived from odontogenic ectomesenchyme of cementoblast origin that forms cementum layer on the roots of a tooth. A case report is presented of a patient treated with surgical excision of Cementoblastoma associated with an unerupted infected right lower third molar tooth. Key words: Cementoblastoma, Odontogenic tumour, unerupted third molar. The cell of origin is cementoblast. INTRODUCTION: Clinically it causes bony expansion. The commonest site is the posterior region of Cementoblastoma is an odontogenic the mandible. In the radiograph it is seen tumor of ectomesenchymal origin. It is as large radiopaque mass associated with also called cementoma. They are large the root of the tooth. We report a case of bulbous mass of cementum or cementum- Benign Cementoblastoma from Sri like tissue on roots of teeth. Ramakrishna Dental College & Hospital, Coimbatore. restriction in opening the mouth and intra oral examination reveals a partially CASE REPORT: erupted third molar tooth with pus discharge. A panoramic radiograph A 41 year old man presented to our showed a radio-opaque, dense, department with a complaint of pain and amorphous, irregularly shaped mass swelling in the right lower half of the face. measuring 2.2 x 1.5cm attached with the Patient gave history of intermittent pain third molar (Fig 1,1a). -
Abbreviations - Diagnosis
Abbreviations - Diagnosis AB abrasion AT attrition CA caries CFL cleft lip CFP cleft palate CLL cervical line lesion - See TR CMO craniomandibular osteopathy DT deciduous (primary) tooth DTC dentigerous cyst E enamel E/D enamel defect E/H enamel hypocalcification or hypoplasia FB foreign body FORL feline odontoclastic resorptive lesion - See TR FX fracture (tooth or jaw) G granuloma G/B buccal granuloma (cheek chewing lesion) G/L sublingual granuloma (tongue chewing lesion) G/E/L eosinophilic granuloma - lip G/E/P eosinophilic granuloma - palate G/E/T eosinophilic granuloma - tongue GH gingival hyperplasia GR gingival recession LAC laceration LAC/B laceration buccal (cheek) LAC/L laceration lip LAC/T laceration tongue MAL malocclusion MAL/1 class 1 malocclusion (neutroclusion - normal jaw relationship, specific teeth are incorrectly positioned) MAL/2 class 2 malocclusion (mandibular distoclusion - mandible shorter than maxilla) MAL/3 class 3 malocclusion (mandibular mesioclusion - maxilla shorter than mandible) BV buccoversion (crown directed towards cheek) CXB caudal crossbite DV distoversion (crown directed away from midline of dental arch) LABV labioversion (crown directed towards lip) LV linguoversion (crown directed towards tongue) MV mesioversion (crown directed towards midline of dental arch) OB open bite RXB rostral crossbite MN mandible or mandibular MN/FX mandibular fracture MX maxilla or maxillary MX/FX maxillary fracture OM oral mass OM/AD adenocarcinoma OM/EPA acanthomatous ameloblastoma (epulis) OM/EPF fibromatous epulis -
6 Development of the Teeth: Root and Supporting Structures Nagat M
AVERY Chap.06 27-11-2002 10:09 Pagina 108 108 II Development of the Teeth and Supporting Structures 6 Development of the Teeth: Root and Supporting Structures Nagat M. ElNesr and James K. Avery Chapter Outline Introduction Introduction... 108 Objectives... 108 Root development is initiated through the contributions Root Sheath Development... 109 of the cells originating from the enamel organ, dental Single-Root Formation... 110 papilla, and dental follicle. The cells of the outer enamel Multiple-Root Formation... 111 epithelium contact the inner enamel epithelium at the Root Formation Anomalies... 112 base of the enamel organ, the cervical loop (Figs. 6.1 and Fate of the Epithelial Root Sheath (Hertwig's Sheath)... 113 6.2A). Later, with crown completion, the cells of the cer- Dental Follicle... 114 vical loop continue to grow away from the crown and Development of (Intermediate) Cementum... 116 become root sheath cells (Figs. 6.2B and 6.3). The inner Cellular and Acellular Cementum... 116 root sheath cells cause root formation by inducing the Development of the Periodontal Ligament... 117 adjacent cells of the dental papilla to become odonto- Development of the Alveolar Process... 119 blasts, which in turn will form root dentin. The root Summary... 121 sheath will further dictate whether the tooth will have Self-Evaluation Review... 122 single or multiple roots. The remainder of the cells of the dental papilla will then become the cells of the root pulp.The third compo- nent in root formation, the dental follicle, is the tissue that surrounds the enamel organ, the dental papilla, and the root. -
Specialized Stem Cell Niche Enables Repetitive Renewal of Alligator Teeth
Specialized stem cell niche enables repetitive renewal PNAS PLUS of alligator teeth Ping Wua, Xiaoshan Wua,b, Ting-Xin Jianga, Ruth M. Elseyc, Bradley L. Templed, Stephen J. Diverse, Travis C. Glennd, Kuo Yuanf, Min-Huey Cheng,h, Randall B. Widelitza, and Cheng-Ming Chuonga,h,i,1 aDepartment of Pathology, University of Southern California, Los Angeles, CA 90033; bDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Hunan 410008, China; cLouisiana Department of Wildlife and Fisheries, Rockefeller Wildlife Refuge, Grand Chenier, LA 70643; dEnvironmental Health Science and eDepartment of Small Animal Medicine and Surgery, University of Georgia, Athens, GA 30602; fDepartment of Dentistry and iResearch Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan City 70101, Taiwan; and gSchool of Dentistry and hResearch Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 10617, Taiwan Edited by Edward M. De Robertis, Howard Hughes Medical Institute/University of California, Los Angeles, CA, and accepted by the Editorial Board March 28, 2013 (received for review July 31, 2012) Reptiles and fish have robust regenerative powers for tooth renewal. replaced from the dental lamina connected to the lingual side of However, extant mammals can either renew their teeth one time the deciduous tooth (15). Human teeth are only replaced one time; (diphyodont dentition) or not at all (monophyodont dentition). however, a remnant of the dental lamina still exists (16) and may Humans replace their milk teeth with permanent teeth and then become activated later in life to form odontogenic tumors (17). lose their ability for tooth renewal. -
Periodontal Ligament, Cementum, and Alveolar Bone in the Oldest Herbivorous Tetrapods, and Their Evolutionary Significance
Periodontal Ligament, Cementum, and Alveolar Bone in the Oldest Herbivorous Tetrapods, and Their Evolutionary Significance Aaron R. H. LeBlanc*, Robert R. Reisz Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada Abstract Tooth implantation provides important phylogenetic and functional information about the dentitions of amniotes. Traditionally, only mammals and crocodilians have been considered truly thecodont, because their tooth roots are coated in layers of cementum for anchorage of the periodontal ligament, which is in turn attached to the bone lining the alveolus, the alveolar bone. The histological properties and developmental origins of these three periodontal tissues have been studied extensively in mammals and crocodilians, but the identities of the periodontal tissues in other amniotes remain poorly studied. Early work on dental histology of basal amniotes concluded that most possess a simplified tooth attachment in which the tooth root is ankylosed to a pedestal composed of ‘‘bone of attachment’’, which is in turn fused to the jaw. More recent studies have concluded that stereotypically thecodont tissues are also present in non-mammalian, non-crocodilian amniotes, but these studies were limited to crown groups or secondarily aquatic reptiles. As the sister group to Amniota, and the first tetrapods to exhibit dental occlusion, diadectids are the ideal candidates for studies of dental evolution among terrestrial vertebrates because they can be used to test hypotheses of development and homology in deep time. Our study of Permo-Carboniferous diadectid tetrapod teeth and dental tissues reveal the presence of two types of cementum, periodontal ligament, and alveolar bone, and therefore the earliest record of true thecodonty in a tetrapod. -
Vestibule Lingual Frenulum Tongue Hyoid Bone Trachea (A) Soft Palate
Mouth (oral cavity) Parotid gland Tongue Sublingual gland Salivary Submandibular glands gland Esophagus Pharynx Stomach Pancreas (Spleen) Liver Gallbladder Transverse colon Duodenum Descending colon Small Jejunum Ascending colon intestine Ileum Large Cecum intestine Sigmoid colon Rectum Appendix Anus Anal canal © 2018 Pearson Education, Inc. 1 Nasopharynx Hard palate Soft palate Oral cavity Uvula Lips (labia) Palatine tonsil Vestibule Lingual tonsil Oropharynx Lingual frenulum Epiglottis Tongue Laryngopharynx Hyoid bone Esophagus Trachea (a) © 2018 Pearson Education, Inc. 2 Upper lip Gingivae Hard palate (gums) Soft palate Uvula Palatine tonsil Oropharynx Tongue (b) © 2018 Pearson Education, Inc. 3 Nasopharynx Hard palate Soft palate Oral cavity Uvula Lips (labia) Palatine tonsil Vestibule Lingual tonsil Oropharynx Lingual frenulum Epiglottis Tongue Laryngopharynx Hyoid bone Esophagus Trachea (a) © 2018 Pearson Education, Inc. 4 Visceral peritoneum Intrinsic nerve plexuses • Myenteric nerve plexus • Submucosal nerve plexus Submucosal glands Mucosa • Surface epithelium • Lamina propria • Muscle layer Submucosa Muscularis externa • Longitudinal muscle layer • Circular muscle layer Serosa (visceral peritoneum) Nerve Gland in Lumen Artery mucosa Mesentery Vein Duct oF gland Lymphoid tissue outside alimentary canal © 2018 Pearson Education, Inc. 5 Diaphragm Falciform ligament Lesser Liver omentum Spleen Pancreas Gallbladder Stomach Duodenum Visceral peritoneum Transverse colon Greater omentum Mesenteries Parietal peritoneum Small intestine Peritoneal cavity Uterus Large intestine Cecum Rectum Anus Urinary bladder (a) (b) © 2018 Pearson Education, Inc. 6 Cardia Fundus Esophagus Muscularis Serosa externa • Longitudinal layer • Circular layer • Oblique layer Body Lesser Rugae curvature of Pylorus mucosa Greater curvature Duodenum Pyloric Pyloric sphincter antrum (a) (valve) © 2018 Pearson Education, Inc. 7 Fundus Body Rugae of mucosa Pyloric Pyloric (b) sphincter antrum © 2018 Pearson Education, Inc. -
The Preservation of Alveolar Bone Ridge During Tooth Extraction Marius Kubilius, Ricardas Kubilius, Alvydas Gleiznys
REVIEWS SCIENTIFIC ARTICLES Stomatologija, Baltic Dental and Maxillofacial Journal, 14: 3-11, 2012 The preservation of alveolar bone ridge during tooth extraction Marius Kubilius, Ricardas Kubilius, Alvydas Gleiznys SUMMARY Objectives. The aims were to overview healing of extraction socket, recommendations for atraumatic tooth extraction, possibilities of post extraction socket bone and soft tissues preservation, augmentation. Materials and Methods. A search was done in Pubmed on key words in English from 1962 to December 2011. Additionally, last decades different scientifi c publications, books from ref- erence list were assessed for appropriate review if relevant. Results and conclusions. There was made intraalveolar and extraalveolar postextractional socket healing overview. There was established the importance and effectiveness of atraumatic tooth extraction and subsequent postextractional socket augmentation in limited hard and soft tissue defects. There are many different methods, techniques, periods, materials in regard to the review. It is diffi cult to compare the data and to give the priority to one. Key words: tooth extraction, grafting, socket, healing, ridge preservation. INTRODUCTION Nowadays tooth extraction becomes more im- portunity to get acknowledge with summarized con- portant in complex odontological treatment. Three temporary scientifi c publication results, methodologies dimensional bones’ and soft tissue parameters infl u- and practical recommendations in preserving alveolar ence further treatment plan, results and long time crest in tooth extraction (validity for atraumatic tooth prognosis. Tooth extraction inevitably has infl uence extraction, operative methods, protection of alveolus in bone resorption and changes in gingival contours. after extractions, feasible post extraction fi llers and Further treatment may become more complex in using complications, alternative treatment).