DOCSLIB.ORG

Ono -- PTH-Pthrp Receptor Signaling in Osterix-Expressing Progenitors.Pdf

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Ono -- PTH-Pthrp Receptor Signaling in Osterix-Expressing Progenitors.Pdf 3/27/14 Root forma)on Cementum Dentin Cementoblast Odontoblast Role of PTH/PTHrP Receptor Signaling on Root Epithelial rests Formaon of Malassez (ERM) Dental Wanida Ono papilla cells AGE Orthodon;cs, Department of Developmental Biology, Harvard School of Dental Medicine Endocrine Unit, MassachuseLs General Hospital and Harvard Medical School Dental follicle cells Hertwig’s epithelial root sheath (HERS) Osterix PTHrP-PPR system • Transcripon factor essen;al to osteoblast differen;aon PTHrP (Nakashima K et al. 2002) PTH/PTHrP receptor (PPR) • Expressed in odontoblasts and alveolar osteoblasts during Gαs Gq tooth development (Chen S et al. 2009) • Controls cellular cementum formaon (Cao Z et al. 2012) • Mediates epithelial-mesenchymal interacons • Osterix-expressing precursors in the perichondrium move • PTHrP is expressed in enamel epithelia/HERS? to bone marrow and become osteoblasts during fetal • PPR is expressed in dental mesenchymes development (Maes C, Kronenberg HM et al. 2010) (Beck et al 1995; Lee Deeds and Segre 1995; Liu et al 1998) • PTHrP is required for tooth erup;on in mice (Philbrick WM, Karaplis AC et al. PNAS 1998) Osterix+ Root-forming • PPR haploinsufficiency is associated with primary cells progenitors failure of tooth erup;on (PFE) in humans ? (Decker E, Weber BH et al. Am J Hum Gen 2008) PTHrP expression paern during root morphogenesis Aims of this study PTHrPLacZ/+ x40 P7 P14 P49 • Iden;fy how osterix-expressing progenitors contribute to murine root morphogenesis • Understand how PTH/PTHrP receptor signal regulates root-forming progenitors PTHrP-LacZ x200 P7 x400 P14 ? PTHrP Epithelial root sheath PPR PTHrP-LacZ Osx+ progenitors Odontoblast PTHrP par;cipates in …….. Dental follicle/papilla cells Cementoblast - dental (root) development - homeostasis of root-bone interface ( composed by PDL, cementum) 1 3/27/14 Experimental approach (1) Working hypothesis • Iden;fy how osterix-expressing progenitors contribute to murine root formaon PTHrP HERS (Epithelial root sheath) Tamoxifen Osx-CreERT2 PPR ? Molar root forma+on P3 P4 P7 P11 P25 Root-forming progenitors Cementoblast CAG Tomato Dental follicle cells X loxP Stop loxP Cre CAG Tomato Rosa26-Tomato In vivo fate mapping of Osx+ cells Osx+ cells are root-forming progenitors Tam P3 P4 P7 P14 P25 Osx+ cells Dental pulp cells Osx-CreER; Tomato P4 (+1d) Dental papilla Odontoblasts Osx+ cells Periodontal ligament cells Dental follicle Postnatal day 4 Cementoblasts Mandibular M1, mid-sagiLal sec;on Alveolar osteoblasts Experimental approach (2) Osx-Cre; PPRflox/+ PPRflox/flox • Understand how PTH/PTHrP receptor signal (PPR) X regulates root-forming progenitors P7 Control CondiIonal Het Condional KO Osx-Cre; PPRflox/+ PTH/PTHrP receptor (PPR) locus E1 E2 PPR floxed allele X Cre (Kobayashi T, Kronenberg HM et al. 2002) E2 PPR null allele PPRflox/flox Osx-Cre; PPRflox/+ Osx-Cre; PPRflox/flox PPRflox/flox 2 3/27/14 PPR signal in Osx+ progenitors are Conclusion essenal for root formaon • Osterix-expressing cells are dental root-forming progenitors during morphogenesis: Osx+ cells PPR signal Osx+ cells become dental pulp cells and odontoblasts, Periodontal ligament cells periodontal ligament cells, cementoblasts and alveolar osteoblasts Dental follicle • Deleon of PTH/PTHrP receptor in Osx+ cells leads to Cementoblasts dental root malformaon and failure of erupon 1) Truncaon of the dental root PPR signal 2) Hypogenesis of periodontal ligament 3) Ankylosis of cementum to bone 4) Underdeveloped mandible 5) Failure of molar erup;on “malformed/ truncated root” Acknowledgement Endocrine Unit / MassachuseLs General Hospital Hank Kronenberg Noriaki Ono Shigeki Nishimori Tatsuya Kobayashi Marc Wein Forest Lai Everyone in the Endocrine Unit HSDM AGE Orthodon;cs Program Acknowledgement for Important Mice… Arthur Broadus PTHrP-LacZ Andrew McMahon Osx-Cre::GFP 3 .
Load more

Recommended publications
  • Experimental Induction of Odontoblast Differentiation and Stimulation During Preparative Processes
    Cells and Materials Volume 3 Number 2 Article 8 1993 Experimental Induction of Odontoblast Differentiation and Stimulation During Preparative Processes H. Lesot Institut de Biologie Médicale C. Begue-Kirn Institut de Biologie Médicale M. D. Kubler Institut de Biologie Médicale J. M. Meyer Institut de Biologie Médicale A. J. Smith Dental School, Birmingham See next page for additional authors Follow this and additional works at: https://digitalcommons.usu.edu/cellsandmaterials Part of the Biomedical Engineering and Bioengineering Commons Recommended Citation Lesot, H.; Begue-Kirn, C.; Kubler, M. D.; Meyer, J. M.; Smith, A. J.; Cassidy, N.; and Ruch, J. V. (1993) "Experimental Induction of Odontoblast Differentiation and Stimulation During Preparative Processes," Cells and Materials: Vol. 3 : No. 2 , Article 8. Available at: https://digitalcommons.usu.edu/cellsandmaterials/vol3/iss2/8 This Article is brought to you for free and open access by the Western Dairy Center at DigitalCommons@USU. It has been accepted for inclusion in Cells and Materials by an authorized administrator of DigitalCommons@USU. For more information, please contact [email protected]. Experimental Induction of Odontoblast Differentiation and Stimulation During Preparative Processes Authors H. Lesot, C. Begue-Kirn, M. D. Kubler, J. M. Meyer, A. J. Smith, N. Cassidy, and J. V. Ruch This article is available in Cells and Materials: https://digitalcommons.usu.edu/cellsandmaterials/vol3/iss2/8 Cells and Materials, Vol. 3, No. 2, 1993 (Pages201-217) 1051-6794/93$5. 00 +. 00 Scanning Microscopy International, Chicago (AMF O'Hare), IL 60666 USA EXPERIMENTAL INDUCTION OF ODONTOBLAST DIFFERENTIATION AND STIMULATION DURING REPARATIVE PROCESSES 1 1 1 2 2 1 H.
    [Show full text]
  • Journal of Dental Research
    Journal of Dental Research http://jdr.sagepub.com/ Cell Differentiation and Matrix Organization in Engineered Teeth A. Nait Lechguer, M.L. Couble, N. Labert, S. Kuchler-Bopp, L. Keller, H. Magloire, F. Bleicher and H. Lesot J DENT RES 2011 90: 583 originally published online 4 February 2011 DOI: 10.1177/0022034510391796 The online version of this article can be found at: http://jdr.sagepub.com/content/90/5/583 Published by: http://www.sagepublications.com On behalf of: International and American Associations for Dental Research Additional services and information for Journal of Dental Research can be found at: Email Alerts: http://jdr.sagepub.com/cgi/alerts Subscriptions: http://jdr.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav >> Version of Record - Apr 13, 2011 OnlineFirst Version of Record - Feb 4, 2011 What is This? Downloaded from jdr.sagepub.com at Service Commun de la Documentation Université de Strasbourg on September 6, 2013 For personal use only. No other uses without permission. © 2011 International & American Associations for Dental Research RESEARCH REPORTS Biomaterials & Bioengineering A. Nait Lechguer1,2, M.L. Couble3,4, N. Labert3,4, S. Kuchler-Bopp1,2, Cell Differentiation and L. Keller1,2, H. Magloire3,4, F. Bleicher3,4, Matrix Organization in and H. Lesot1,2* Engineered Teeth 1INSERM UMR 977, Faculté de Médecine, 11, rue Humann, F-67085 Strasbourg, France; 2Dental School, University of Strasbourg, Strasbourg, France; 3Université de Lyon, Faculté d’Odontologie, Rue Guillaume Paradin, F-69372 Lyon Cedex 08, France; and 4IGFL, CNRS UMR 5242, Ecole Normale Supérieure, 46 Allée d’Italie, 69364, Lyon Cedex 08, France; *corresponding author, [email protected] J Dent Res 90(5):583-589, 2011 ABSTRACT InTRODuCTIOn Embryonic dental cells were used to check a series of criteria to be achieved for tooth engineering.
    [Show full text]
  • Benign Cementoblastoma Associated with an Unerupted Third Molar - a Case Report
    CORE Metadata, citation and similar papers at core.ac.uk Provided by Directory of Open Access Journals BENIGN CEMENTOBLASTOMA ASSOCIATED WITH AN UNERUPTED THIRD MOLAR - A CASE REPORT J.Dinakar* M.S.Senthil Kumar** Shiju Mathew Jacob*** *Professor & HOD, Department of Oral Pathology, ** Reader, *** Lecturer, Department of Oral Surgery, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamilnadu, India. ABSTRACT: Cementoblastoma is a rare odontogenic tumor derived from odontogenic ectomesenchyme of cementoblast origin that forms cementum layer on the roots of a tooth. A case report is presented of a patient treated with surgical excision of Cementoblastoma associated with an unerupted infected right lower third molar tooth. Key words: Cementoblastoma, Odontogenic tumour, unerupted third molar. The cell of origin is cementoblast. INTRODUCTION: Clinically it causes bony expansion. The commonest site is the posterior region of Cementoblastoma is an odontogenic the mandible. In the radiograph it is seen tumor of ectomesenchymal origin. It is as large radiopaque mass associated with also called cementoma. They are large the root of the tooth. We report a case of bulbous mass of cementum or cementum- Benign Cementoblastoma from Sri like tissue on roots of teeth. Ramakrishna Dental College & Hospital, Coimbatore. restriction in opening the mouth and intra oral examination reveals a partially CASE REPORT: erupted third molar tooth with pus discharge. A panoramic radiograph A 41 year old man presented to our showed a radio-opaque, dense, department with a complaint of pain and amorphous, irregularly shaped mass swelling in the right lower half of the face. measuring 2.2 x 1.5cm attached with the Patient gave history of intermittent pain third molar (Fig 1,1a).
    [Show full text]
  • Lecture 2 – Bone
    Oral Histology Summary Notes Enoch Ng Lecture 2 – Bone - Protection of brain, lungs, other internal organs - Structural support for heart, lungs, and marrow - Attachment sites for muscles - Mineral reservoir for calcium (99% of body’s) and phosphorous (85% of body’s) - Trap for dangerous minerals (ex:// lead) - Transduction of sound - Endocrine organ (osteocalcin regulates insulin signaling, glucose metabolism, and fat mass) Structure - Compact/Cortical o Diaphysis of long bone, “envelope” of cuboid bones (vertebrae) o 10% porosity, 70-80% calcified (4x mass of trabecular bone) o Protective, subject to bending/torsion/compressive forces o Has Haversian system structure - Trabecular/Cancellous o Metaphysis and epiphysis of long bone, cuboid bone o 3D branching lattice formed along areas of mechanical stress o 50-90% porosity, 15-25% calcified (1/4 mass of compact bone) o High surface area high cellular activity (has marrow) o Metabolic turnover 8x greater than cortical bone o Subject to compressive forces o Trabeculae lined with endosteum (contains osteoprogenitors, osteoblasts, osteoclasts) - Woven Bone o Immature/primitive, rapidly growing . Normally – embryos, newborns, fracture calluses, metaphyseal region of bone . Abnormally – tumors, osteogenesis imperfecta, Pagetic bone o Disorganized, no uniform orientation of collagen fibers, coarse fibers, cells randomly arranged, varying mineral content, isotropic mechanical behavior (behavior the same no matter direction of applied force) - Lamellar Bone o Mature bone, remodeling of woven
    [Show full text]
  • Dental Cementum Reviewed: Development, Structure, Composition, Regeneration and Potential Functions
    Braz J Oral Sci. January/March 2005 - Vol.4 - Number 12 Dental cementum reviewed: development, structure, composition, regeneration and potential functions Patricia Furtado Gonçalves 1 Enilson Antonio Sallum 1 Abstract Antonio Wilson Sallum 1 This article reviews developmental and structural characteristics of Márcio Zaffalon Casati 1 cementum, a unique avascular mineralized tissue covering the root Sérgio de Toledo 1 surface that forms the interface between root dentin and periodontal Francisco Humberto Nociti Junior 1 ligament. Besides describing the types of cementum and 1 Dept. of Prosthodontics and Periodontics, cementogenesis, attention is given to recent advances in scientific Division of Periodontics, School of Dentistry understanding of the molecular and cellular aspects of the formation at Piracicaba - UNICAMP, Piracicaba, São and regeneration of cementum. The understanding of the mechanisms Paulo, Brazil. involved in the dynamic of this tissue should allow for the development of new treatment strategies concerning the approach of the root surface affected by periodontal disease and periodontal regeneration techniques. Received for publication: October 01, 2004 Key Words: Accepted: December 17, 2004 dental cementum, review Correspondence to: Francisco H. Nociti Jr. Av. Limeira 901 - Caixa Postal: 052 - CEP: 13414-903 - Piracicaba - S.P. - Brazil Tel: ++ 55 19 34125298 Fax: ++ 55 19 3412 5218 E-mail: [email protected] 651 Braz J Oral Sci. 4(12): 651-658 Dental cementum reviewed: development, structure, composition, regeneration and potential functions Introduction junction (Figure 1). The areas and location of acellular Cementum is an avascular mineralized tissue covering the afibrillar cementum vary from tooth to tooth and along the entire root surface. Due to its intermediary position, forming cementoenamel junction of the same tooth6-9.
    [Show full text]
  • Basic Histology (23 Questions): Oral Histology (16 Questions
    Board Question Breakdown (Anatomic Sciences section) The Anatomic Sciences portion of part I of the Dental Board exams consists of 100 test items. They are broken up into the following distribution: Gross Anatomy (50 questions): Head - 28 questions broken down in this fashion: - Oral cavity - 6 questions - Extraoral structures - 12 questions - Osteology - 6 questions - TMJ and muscles of mastication - 4 questions Neck - 5 questions Upper Limb - 3 questions Thoracic cavity - 5 questions Abdominopelvic cavity - 2 questions Neuroanatomy (CNS, ANS +) - 7 questions Basic Histology (23 questions): Ultrastructure (cell organelles) - 4 questions Basic tissues - 4 questions Bone, cartilage & joints - 3 questions Lymphatic & circulatory systems - 3 questions Endocrine system - 2 questions Respiratory system - 1 question Gastrointestinal system - 3 questions Genitouirinary systems - (reproductive & urinary) 2 questions Integument - 1 question Oral Histology (16 questions): Tooth & supporting structures - 9 questions Soft oral tissues (including dentin) - 5 questions Temporomandibular joint - 2 questions Developmental Biology (11 questions): Osteogenesis (bone formation) - 2 questions Tooth development, eruption & movement - 4 questions General embryology - 2 questions 2 National Board Part 1: Review questions for histology/oral histology (Answers follow at the end) 1. Normally most of the circulating white blood cells are a. basophilic leukocytes b. monocytes c. lymphocytes d. eosinophilic leukocytes e. neutrophilic leukocytes 2. Blood platelets are products of a. osteoclasts b. basophils c. red blood cells d. plasma cells e. megakaryocytes 3. Bacteria are frequently ingested by a. neutrophilic leukocytes b. basophilic leukocytes c. mast cells d. small lymphocytes e. fibrocytes 4. It is believed that worn out red cells are normally destroyed in the spleen by a. neutrophils b.
    [Show full text]
  • The Role of Transforming Growth Factor Beta in Tertiary Dentinogenesis
    The role of transforming growth factor beta in tertiary dentinogenesis Tetiana Haniastuti1, Phides Nunez2, and Ariadna A. Djais3 1Department of Oral Biology, Gadjah Mada University, Indonesia 2Division of Oral Ecology in Health and Infection, Niigata University, Japan 3Department of Oral Biology, University of Indonesia, Indonesia ABSTRACT The most visible repair response to pulp injury is the deposition of a tertiary dentin matrix over the dentinal tubules of the primary or secondary dentin. Tertiary dentin is distinguished as reactionary and reparative dentin, depending on the severity of the initiating response and the conditions under which the newly deposited dentin matrix was elaborated. Transforming growth factor beta (TGF-b) superfamily is a large group of growth factors that serve important roles in regulating cell growth, differentiation, and function. Members of this superfamily have been implicated in the repair process of the dental tissue after injury. Although numerous studies have proved that those bioactive molecules carry out an important role in the formation of tertiary dentin, comprehensive report regarding that phenomenon is not yet available. This review article aimed to summarize the role of TGF-b on tertiary dentinogenesis during the progression of a carious lesion. Key words: transforming growth factor beta, tertiary dentinogenesis, reactionary dentin, reparative dentin Correspondence: Tetiana Haniastuti, c/o: Bagian Biologi Oral, Fakultas Kedokteran Gigi Universitas Gadjah Mada. Jln. Denta no. 1, Sekip Utara Yogyakarta 55281, Indonesia. E-mail: [email protected] INTRODUCTION such as cell proliferation, differentiation, and matrix synthesis. Recent studies showed that this substance has a The complex structural composition of teeth provides significant role in the immune response7 and tissue repair8 hardness and durability as a barrier against bacterial of the dental pulp.
    [Show full text]
  • Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages
    Downloaded from http://cshperspectives.cshlp.org/ on October 6, 2021 - Published by Cold Spring Harbor Laboratory Press Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages Maria Jussila and Irma Thesleff Developmental Biology Program Institute of Biotechnology, Biokeskus 1, P.O. Box 56, University of Helsinki, Helsinki FIN-00014, Finland Correspondence: maria.jussila@helsinki.fi SUMMARY Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth organogenesis is regulated by an intricate network of cell–cell signaling during all steps of development. The dental hard tissues, dentin, enamel, and cementum, are formed by unique cell types whose differentiation is intimately linked with morphogenesis. During evolution the capacity for tooth replacement has been reduced in mammals, whereas teeth have acquired more complex shapes. Mammalian teeth contain stem cells but they may not provide a source for bioengineering of human teeth. Therefore it is likely that nondental cells will have to be reprogrammed for the purpose of clinical tooth regeneration. Obviously this will require understanding of the mechanisms of normal development. The signaling networks mediating the epithelial-mesenchymal interactions during morphogenesis are well characterized but the molecular signatures of the odontogenic tissues remain to be uncovered. Outline 1 Morphogenesis and cell 4 Regulation of tooth replacement, continuous differentiation during tooth development growth, and stem cells in teeth 2 Signal networks and signaling centers 5 Future challenges: stem cell-based bioengineering of teeth 3 Regulation of the identity and 6 Concluding remarks differentiation of odontogenic mesenchymal and epithelial cell lineages References Editors: Patrick P.L.
    [Show full text]
  • Original Article BMP-2 Downregulation Is Involved in the Inhibition of Cementoblast Differentiation by Lithium
    Int J Clin Exp Med 2016;9(2):823-830 www.ijcem.com /ISSN:1940-5901/IJCEM0017314 Original Article BMP-2 downregulation is involved in the inhibition of cementoblast differentiation by lithium Shang Gao1*, Xing-Fu Bao1*, Yu-Zhuo Wang1, Jing-Zheng Yi2, Min Hu1 1Department of Orthodontics, Stomatological Hospital of Jilin University, China; 2University of California in San Diego, USA. *Equal contributors. Received October 5, 2015; Accepted December 8, 2015; Epub February 15, 2016; Published February 29, 2016 Abstract: Cementum, which is formed by cementoblast, plays an important role in periodontal regeneration. Wnt signalling and BMP-2 are involved in the regulation of cementoblast differentiation, but little is known about the effect of lithium, an agonist of Wnt signalling, on cementoblast behaviour. In this research, OCCM-30 cementoblast was employed to investigate the influence of various concentrations of lithium on proliferation and differentiation. Cell metabolic assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, cell staining, alizarin red staining and alkaline phosphatase assay were performed. BMP-2 expression was also compared among different groups. Results showed no significant difference in proliferation, whereas differentiation was inhibited in the pres- ence of lithium. Given these results, along with previous reports, BMP-2 downregulation is involved in the inhibition of cementoblast differentiation by lithium. Keywords: Lithium, cementoblast, BMP-2 Introduction Bone morphogenetic protein 2 (BMP-2) is an autocrine and paracrine growth factor that is Cementum is a type of special mineralized tis- essential for the growth of mineralized tissue. sue covering tooth root that protects dental In osteoblasts, BMP-2 promotes the differentia- pulp from external stimulation.
    [Show full text]
  • Role of Connexin 43 in Odontoblastic Differentiation and Structural Maintenance in Pulp Damage Repair
    International Journal of Oral Science www.nature.com/ijos ARTICLE OPEN Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair Jiaxin Yin1,2, Jue Xu3, Ran Cheng1, Meiying Shao3, Yuandong Qin1, Hui Yang1 and Tao Hu1 Dental pulp can initiate its damage repair after an injury of the pulp–dentin complex by rearrangement of odontoblasts and formation of newly differentiated odontoblast-like cells. Connexin 43 (Cx43) is one of the gap junction proteins that participates in multiple tissue repair processes. However, the role of Cx43 in the repair of the dental pulp remains unclear. This study aimed to determine the function of Cx43 in the odontoblast arrangement patterns and odontoblastic differentiation. Human teeth for in vitro experiments were acquired, and a pulp injury model in Sprague-Dawley rats was used for in vivo analysis. The odontoblast arrangement pattern and the expression of Cx43 and dentin sialophosphoprotein (DSPP) were assessed. To investigate the function of Cx43 in odontoblastic differentiation, we overexpressed or inhibited Cx43. The results indicated that polarized odontoblasts were arranged along the pulp–dentin interface and had high levels of Cx43 expression in the healthy teeth; however, the odontoblast arrangement pattern was slightly changed concomitant to an increase in the Cx43 expression in the carious teeth. Regularly arranged odontoblast-like cells had high levels of the Cx43 expression during the formation of mature dentin, but the odontoblast- like cells were not regularly arranged beneath immature osteodentin in the pulp injury models. Subsequent in vitro experiments demonstrated that Cx43 is upregulated during odontoblastic differentiation of the dental pulp cells, and inhibition or overexpression of Cx43 influence the odontoblastic differentiation.
    [Show full text]
  • Dental Manifestations in Bariatric Patients – Review of Literature
    www.scielo.br/jaos Dental manifestations in bariatric patients – review of literature Carolina Silveira BARBOSA1, Gabriel Salles BARBÉRIO1, Vinicius Rizzo MARQUES1, Vitor de Oliveira BALDO1, Marília Afonso Rabelo BUZALAF2, Ana Carolina MAGALHÃES3 1- Undergraduate student, Bauru School of Dentistry, University of São Paulo. 2- DDS, MSc, PhD, Full Professor, Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo. 3- DDS, MSc, PhD, Assistant Professor, Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo. Corresponding address: Ana Carolina Magalhães - Faculdade de Odontologia de Bauru - Universidade de São Paulo - Departamento de Ciências Biológicas - Al. Octávio Pinheiro Brisolla, 9-75 Bauru-SP 17012-901 (Brazil) - Phone: + 55 14 32358246 Fax: + 55 14 32343164 - e-mail: [email protected] Received: August 19, 2009 - Accepted: February 19, 2010 ABSTRACT he rate of bariatric surgery has significantly risen in the past decade as an increasing Tprevalence of extreme obesity can be observed. Although bariatric surgery is an effective therapeutic modality for extreme obesity, it is associated with risk factors affecting also oral health. Based on an overview of the current literature, this paper presents a summary of dental manifestations in bariatric patients. Bariatric surgeries are associated with an increased risk for gastro-esophageal reflux which in turn might account for the higher amount of carious and erosive lesions observed in bariatric patients. As a result, also dentin hypersensitivity might be observed more frequently. The current data indicate that recommended postsurgical meal patterns and gastric reflux might increase the risk for dental lesions, particularly in the presence of other risk factors, such as consumption of sweet-tasting foods and acidic beverages.
    [Show full text]
  • Title Erupted Complex Odontoma Delayed Eruption of Permanent
    Erupted complex odontoma delayed eruption of Title permanent molar Author(s) Ohtawa, Y; Ichinohe, S; Kimura, E; Hashimoto, S Journal Bulletin of Tokyo Dental College, 54(4): 251-257 URL http://hdl.handle.net/10130/5321 Right Description Posted at the Institutional Resources for Unique Collection and Academic Archives at Tokyo Dental College, Available from http://ir.tdc.ac.jp/ Bull Tokyo Dent Coll (2013) 54(4): 251–257 Case Report Erupted Complex Odontoma Delayed Eruption of Permanent Molar Yumi Ohtawa, Saori Ichinohe*, Eri Kimura* and Sadamitsu Hashimoto** Division of Special Needs Dentistry, Department of Oral Health Science, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan * Division of Pediatric Dentistry, Department of Oral Health Science, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan ** Department of Biology, Tokyo Dental College, 2-9-7 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan Received 26 April, 2013/Accepted for publication 10 June, 2013 Abstract Odontomas, benign tumors that develop in the jaw, rarely erupt into the oral cavity. We report an erupted odontoma which delayed eruption of the first molar. The patient was a 10-year-old Japanese girl who came to our hospital due to delayed eruption of the right maxillary first molar. All the deciduous teeth had been shed. The second premolar on the right side had erupted, but not the first molar. Slight inflammation of the alveolar mucosa around the first molar had exposed a tooth-like, hard tissue. Panoramic radiog- raphy revealed a radiopaque mass indicating a lesion approximately 1 cm in diameter.
    [Show full text]