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(12) United States Patent (10) Patent No.: US 9,399,762 B2 Far Well Et Al US0093.99762B2 (12) United States Patent (10) Patent No.: US 9,399,762 B2 Far Well et al. (45) Date of Patent: Jul. 26, 2016 (54) METHODS AND SYSTEMS FOR 540,145 SULFMIDATION OR SULFOXMIDATION 2011 0196086 A1 8/2011 Matsushita et al. 2012/0237591 A1 9/2012 Cullis et al. OF ORGANIC MOLECULES FOREIGN PATENT DOCUMENTS (71) Applicant: The California Institute of Technology, Pasadena, CA (US) EP O 200 638 B1 4f1986 WO 2007 144599 A2 12/2007 (72) Inventors: Christopher C. Farwell, Thousand WO 2011, 1595.50 A3 12/2011 Oaks, CA (US); John A. McIntosh, OTHER PUBLICATIONS Pasadena, CA (US); Frances H. Arnold, Wang et al. Angewandte Chemie. Int. Ed., 2013, 52(33), 8661-65.* La Canada, CA (US) Mancheno et al. Organic Letters, 2006, 8(11).2349-52.* Adams, PD. et al., “PHENIX: a comprehensive Python-based system for macromolecular structure solution.” Acta Crystallogr., Sect. 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