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2017.12.26 12:09:36 -05'00' UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON D.C., 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION PC Code: 099050 DP Barcode: 441940 Date: December 22, 2017 MEMORANDUM SUBJECT: Registration Review: Preliminary Environmental Fate and Ecological Risk Assessment for Acetamiprid TO: Margaret Hathaway, Chemical Review Manager Nicole Zinn, Team Leader Kevin Costello, Branch Chief Risk Management and Implementation Branch 2 Pesticide Re-evaluation Division (7508P) FROM: Cameron Douglass, Ph.D., Biologist Katrina White, Ph.D., Senior Fate Scientist Environmental Risk Branch IV Environmental Fate and Effects Division (7507P) REVIEWED BY: Cheryl Sutton, Ph.D., Fate Scientist Thomas Steeger, Ph.D., Senior Science Advisor Environmental Risk Branch IV Environmental Fate and Effects Division (7507P) APPROVED BY: Jean Holmes, DVM, Branch Chief Environmental Risk Branch IV Environmental Fate and Effects Division (7507P) The Environmental Fate and Effects Division (EFED) has completed the preliminary environmental fate and ecological risk assessment in support of the Registration Review of the insecticide acetamiprid (N1- [(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine; USEPA PC Code: 099050; CAS Number: 135410-20-7). Attachment: Preliminary Environmental Fate and Ecological Risk Assessment in Support of the Registration Review of Acetamiprid 1 Preliminary Environmental Fate and Ecological Risk Assessment in Support of the Registration Review of Acetamiprid N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine USEPA PC Code: 099050 CAS Number: 135410-20-7 Prepared by: U. S. Environmental Protection Agency Cameron Douglass, Ph.D., Biologist Office of Pesticide Programs Katrina White, Ph.D., Senior Fate Scientist Environmental Fate and Effects Division Reviewed by: Environmental Risk Branch IV Cheryl Sutton, Ph.D., Fate Scientist 1200 Pennsylvania Ave., NW Thomas Steeger, Ph.D., Senior Science Advisor Mail Code 7507P Jean Holmes, D.V.M., Branch Chief Washington, DC 20460 December 22, 2017 2 Contents 1. Executive Summary .............................................................................................................. 5 1.1. Risk Conclusions Summary ................................................................................................5 1.2. Environmental Fate Summary ............................................................................................6 1.3. Ecological Effects Summary ..............................................................................................7 1.4. Identification of Data Needs ...............................................................................................7 2. Problem Formulation Update .............................................................................................. 9 2.1. Nature of Regulatory Action ............................................................................................10 2.2. Target Pests and Mode of Action .....................................................................................10 2.3. Currently Registered Use Patterns ....................................................................................10 2.3.A. Summary of Products and Overview of Usage (update for PRA) ........................ 10 2.3.B. Agricultural Uses and Residential Uses on Plants ................................................ 11 2.3.C. Use on Trees ......................................................................................................... 12 2.3.D. Residential and Structural Uses ............................................................................ 13 2.3.E. Other Use Patterns ................................................................................................ 14 2.3.F. Usage Information ................................................................................................ 14 2.4. Most Recently Completed Ecological Risk Assessment ..................................................15 2.5. Identification of Residues of Concern ..............................................................................16 2.6. Analysis Plan ....................................................................................................................18 2.6.A. New Studies and Procedures ................................................................................. 19 2.6.B. Measures of Exposure ........................................................................................... 20 3. Analysis ................................................................................................................................ 21 3.1. Environmental Fate Summary ..........................................................................................21 3.2. Measures of Aquatic Exposure .........................................................................................26 3.2.A. Aquatic Modeling Input Parameters ..................................................................... 26 3.2.B. Monitoring Data .................................................................................................... 32 3.3. Measures of Terrestrial Exposure .....................................................................................33 3.3.A. Ingestion of Surface Residues by Birds and Mammals ........................................ 33 3.3.B. Exposure to Honey Bees ....................................................................................... 37 3.3.C. Exposure to Terrestrial Plants ............................................................................... 38 3.4. Ecological Effects Characterization .................................................................................38 3.4.A. Aquatic Toxicity Assessment ............................................................................... 39 3.4.B. Terrestrial Organisms............................................................................................ 42 4. Risk Characterization ......................................................................................................... 48 4.1. Risk Estimation .................................................................................................................49 4.1.A. RQ Values for Aquatic Organisms ....................................................................... 49 4.1.B. RQ Values for Terrestrial Organisms ................................................................... 51 4.1.C. RQ Values for Terrestrial Invertebrates ................................................................ 56 4.1.D. RQ Values for Terrestrial Plants ........................................................................... 57 4.1.E. Incident Database Review ..................................................................................... 58 4.2. Risk Description ...............................................................................................................60 4.2.A. Risk to Aquatic Organisms ................................................................................... 60 4.2.B. Risk to Terrestrial Organisms ............................................................................... 64 4.2.C. Conclusion ............................................................................................................ 73 3 5. Literature Cited .................................................................................................................. 73 6. Registrant Submitted Studies List ..................................................................................... 78 Appendices Appendix A. Supplemental Environmental Fate Information ..................................................... 97 Appendix B. Summary of Available Effects Studies................................................................. 105 Appendix C. Sample T-REX Input and Output ......................................................................... 118 Appendix D. Sample BeeREX Input and Output ...................................................................... 124 Appendix E. Sample TerrPlant Input and Output ...................................................................... 125 Appendix F. Cranberry Aquatic Modeling Scenarios and Approach ........................................ 126 Appendix G. Example Aquatic Modeling Output and Input Batch Files .................................. 131 Appendix H. Method of Estimating Aquatic Exposure from Urban/Residential Uses ............. 134 Appendix I. Summary of End-Use Products that Contain Acetamiprid and Additional Active Ingredients ............................................................................................................ 135 Appendix J. Agricultural Acetamiprid Uses ............................................................................... 136 Appendix K. Estimated Environmental Concentrations for Acetamiprid Alone and with Different Drift Assumptions ................................................................................. 139 Appendix L. Acute and Chronic RQs (Mean Kenaga Values) for Terrestrial Animals Based on the Evaluated Uses of Acetamiprid (and Using a Foliar Dissipation Half-life of 35 Days) .................................................................................................................... 142 4 1. Executive Summary Acetamiprid is a broad-spectrum cyano-substituted neonicotinoid insecticide used to control a wide variety of insect pests including sucking insects, bed bugs, termites, and ants. Acetamiprid is systemic in plants
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