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PBNX 22 Page 2 of 306 Page 1 of 306 A Benefits Document Supporting the Continued Registration of Flubendiamide (Belt® SC) Data Requirements None Authors J.E. Nelson, Ph.D. L.L. Schneider, J.D. N.A. Hummel, Ph.D. J.W. Bell Completion Date May 20, 2015 Performing Laboratories Bayer CropScience LP 2 T.W. Alexander Drive Research Triangle Park, NC 27709 Nelson-Schneider Consulting LLC 12053 Hawthorn Ridge Fishers, IN 46037 Submitting Laboratory Bayer CropScience LP 2 T.W. Alexander Drive Research Triangle Park, NC 27709 PBN0111 PBNX 22 Page 2 of 306 STATEMENT OF DATA CONFIDENTIALITY Information claimed confidential on the basis of its falling within the scope of FIFRA, Section 10(d),1(A), (B), or (C) has been removed throughout the document to a Confidential Business Information Appendix and replaced with a numerically sequenced placeholder sentence, “CBIx text located in the Confidential Business Information Appendix”. Company: Bayer CropScience Company Agent: Date: Note: Notwithstanding the declaration made above, the data contained within the report in its entirety are the property of Bayer CropScience AG and, as such, are considered to be a trade secret and confidential for all purposes other than compliance with FIFRA 10. Submission of these data in compliance with FIFRA does not constiture a waiver of any right to confidentiality which may exist under any other statue or in any country other than the USA. 2 PBN0112 Page 3 of 306 Bayer CropScience AG GOOD LABORATORY PRACTICE STATEMENT This document is informational, and is not the result of a study as defined by 40 CFR 160.3. Since the document does not report a study, no GLP (40 CFR 160 or Current OECD Principles of Good Laboratory Practices) statement is required as per PR Notice 2011-3 (VI)(C)(3), p. 11. Study Director: There is no study director for this document Sponsor/Submitter: Date: __________________ Signature (YYYY-MM-DD) Typed Name of Signer: Typed Name of Company: PBN0113 Page 4 of 306 Note to Reviewer: Confidential Business Information (CBI) has been removed to a Confidential Appendix F, and replaced throughout the document with a numerically sequenced placeholder sentence, “CBIx text located in the Confidential Business Information Appendix”. In the Confidential Business Information Appendix, the CBI text can be found in numerical sequence corresponding to the placeholder sentence noted above. Note to Reviewer: This document is best read using Adobe. PBN0114 Page 5 of 306 Note to Reviewer: The following pesticide names may be used interchangeably. TABLE 1. Pesticide, Seed Brand and Trait Names Referenced in this Document. Common Name Product Name (EPA Reg. No.) --- Bollgard®II1 Insect Protected Cotton Abamectin Agri-Mek®2, Numerous brands (numerous) Acephate Orthene®3 , Numerous brands (numerous) Acetamiprid Assail®4 (8033-36-70506) Alpha-cypermethrin FastacTM 5 (7969-298) Bifenthrin Brigade®6 , Capture®7 , Numerous brands (numerous) Tourismo8 (71711-33) Buprofezin + flubendiamide Vetica9 (71711-32) Altacor®10 (352-730) Chlorantraniliprole Coragen®11 (352-729) Prevathon®12 (352-844) Clorantraniliprole + lambda- Voliam Xpress®13 (100-1320) cyhalothrin Clofentezine Apollo®14 (66222-47) Exirel®15 (352-859) Cyantranilipriole Verimark®16 (352-860) Cyfluthrin Baythroid®17 (264-840) Cypermethrin Ammo®18 (279-3027-5905) Deltamethrin Delta Gold®19(264-1011-1381) Dicofol Dicofol 4E® (66222-56) Diflubenzuron Dimilin®20 (400-461) Esfenvalerate Asana XL®21 (59639-209) Fenpropathrin Danitol®22 (59639-35) Flubendiamide Belt®23 SC (264-1025) Gamma-cyhalothrin Declare®24 (67760-96) Gamma-cyhalothrin + spinosyn Consero®25(34704-953) Hexythiazox Savey®26 (10163-250) Imidacloprid Admire® Pro27(264-827) Indoxacarb Avaunt®28 (352-597) PBN0115 Page 6 of 306 Common Name Product Name (EPA Reg. No.) Steward EC29 (352-638) Karate®30 (100-1097) Lambda-cyhalothrin Warrior®31 (100-1295) Lambda-cyhalothrin + thiamethoxam Voliam Flexi®32(100-1319) Methomyl Lannate LV ®33 (352-384) Methoxyfenozide Intrepid®34 (62719-442) Methoxyfenozide + spinetoram Intrepid Edge™35 (62719-666) Novaluron Rimon 0.83®36 (66222-35-400) Permethrin Numerous brands (numerous) Phosmet Imidan®37 (10163-169) Pyrethrins Numerous brands (numerous) Delegate®38 (62719-541) Spinetoram Radiant®39 (62719-545) SpinTor®40 (62719-294) Success®41 (62719-292) Tracer®42 (62719-267) Spinosad or spinosyn Blackhawk®43 (62719-523) Entrust®44 (62719-621) Conserve SC®45 (62719-291) Thiodicarb Larvin 3.2®46 (264-379) Zeta-cypermethrin Mustang®47 (279-3426) PBN0116 Page 7 of 306 Note to Reviewer: The following insect names may be used interchangeably in this document. TABLE 2. Common and Scientific Names of Insects Referenced in this Document. Insects Common Name Scientific Name Ants Various species Aphid Various species Alfalfa looper Autographa californica Eurpopean Apple Saw Fly Hoplocampa testudinea Apple maggot Rhagoletis pomonella Armyworms Various species Beet armyworm Spodoptera exigua Bertha armyworm Mamestra configurata Black cutworm Agrotis ipsilon Braconid wasp Various species Bumblebee Bombus spp. Cabbage looper Trichoplusia ni Cabbage maggot Hylemya brassicae Cherry fruit fly Rhagoletis cingulata Codling moth Cydia pomonella Corn earworm Helicoverpa zea Cotton bollworm Helicoverpa zea Cotton leaf perforator Bucculatrix thurberiella Cotton leafworm Spodoptera littoralis Cutworms Agrotis spp. Diamondback moth Plutella xylostella European corn borer Ostrinia nubilalis Eyespotted bud moth Spilonota ocellana Fall armyworm Spodoptera frugiperda Fall webworm Hyphantria cunea Fireants Solenopsis invicta Fleabeetles Epitrix spp., others Flies Various species Grape leaffolder Desmia funeralis Grapeleaf skeletonizer Harrisinia americana Green fruitworm Lithophane antennata Green lacewing Various species Hickory shuckworm Cydia caryana Honeybee Apis mellifera Horn-faced bee Osmia cornifrons Hornworms Manduca spp. Imported cabbageworm Pieris rapae PBN0117 Page 8 of 306 Insects Common Name Scientific Name Katydids Tettigoniidae spp. Laconobia fruitworm Lacanobia subjuncta Harmonia axyridis and Coccinella Lady beetle septempunctata Liriomyza leafminers Liriomyza trifolii, L. huidobrensis, L. sativae Choristoneura spp., Pandemis spp., Archips Leafrollers spp., others Lepidoptera leafminers Various species Lesser appleworm Grapholita prunivora Loopers Trichoplusia spp., others Lygus bug Lygus spp. Melonworm Diaphania hyalinata Mites Various species Navel orangeworm Ameylois transitella Obliquebanded leafroller Choristoneura rosaceana Omnivorous leafroller Platynota stultana Orange tortrix Argyrotaenia citrana Oriental fruit moth Grapholita molesta Paper wasp Polistes spp. and others Encarsia formosa, Aphidius colemani, Cotesia glomerata, Campoletis sonorensis, Parasitic wasp Goniozus legneri, and Pentalitomatix plecthricus Peachtree borer Synanthedon exitiosa Peach twig borer Anarsia lineatella Pear psylla Cacopsylla pyricola Pecan nut casebearer Acrobasis nuxvorella Pecan weevil Curculio caryae Pickleworm Diaphania nitidalis Plum curculio Conotrachelus nenuphar Predatory bug Orius spp. Predatory midge Aphidoletes aphidimyza Amblyseius cucumeris and Phytoseiulus Predatory mite persimilis Redbanded leafroller Argyrotaenia velutinana Redheaded pine sawfly Neodiprion lecontei Redhumped caterpillar Schizura concinna Rindworms Various species Saltmarsh caterpillar Estigmene acrea San Jose scale Quadraspidiotus perniciosus Sawflies Various species Scales Various species Serpentine leafminer Liriomyza brassicae PBN0118 Page 9 of 306 Insects Common Name Scientific Name Silkworm Bombyx mori Southern armyworm Spodoptera eridania Southwestern corn borer Diatraea grandiosella Pardosa pseudoannulata and Misumenops Spider tricuspidatus Spined stiltbug Jalysus spinosus Spotted tentiform leafminer Phyllonorycter blancardella Stilt bug Jalysus wickhami Stinkbug Various species Tachinid fly Various species Tent caterpillar Malacosoma spp. Thrips Frankliniella spp, Thrips spp, others Tobacco budworm Heliothis virescens Tomato fruitworm Helicoverpa zea Tomato pinworm Keiferia lycopersicella Tufted apple budmoth Platynota idaeusalis Tussock moths Orgyia spp. Variegated leafroller Platynota flavendana Walnut caterpillar Datana integerrima Walnut husk fly Rhagoletis completa Western bean cutworm Richia albicosta Western cherry fruit fly Rhagoletis indifferens Western flower thrips Frankliniella occidentalis Western raspberry fruitworm Byturus bakeri Western tussock moth Orgyia vetusta Western Yellowstriped armyworm Spodopera praefica Whiteflies Trialeurodes vaporariorum and others Worms Various species Yellowstriped armyworm Spodoptera ornithogalli PBN0119 Page 10 of 306 Note to Reviewer: The following definitions are implied in this document: Bayer CropScience (BCS): Bayer CropScience LP. Crop Safety: The ability of a crop to recover from inadvertent or accidental exposure to a pesticide. Crop Tolerance: The ability of a crop to tolerate or withstand the action of an applied pesticide. Driver Insect Pests: Difficult to control economically important insect species. Growers generally focus insect control practice decisions on management of driver insect species. Driver insects include beet armyworm, navel orangeworm, soybean looper, corn earworm and tobacco budworm. Economic Threshold: In general terms an economic threshold would be considered as the cost- benefit relationship of treating a crop in this case with an insecticide. This economic threshold varies based on the specific crop and pest as well as the potential injury at various stages of development, varying climatic
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