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Acer Therapeutics Inc. Form 8-K Current Event Report Filed 2021-06

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SECURITIES AND EXCHANGE COMMISSION FORM 8-K Current report filing Filing Date: 2021-06-17 | Period of Report: 2021-06-17 SEC Accession No. 0001564590-21-033350 (HTML Version on secdatabase.com) FILER Acer Therapeutics Inc. Mailing Address Business Address ONE GATEWAY CENTER ONE GATEWAY CENTER CIK:1069308| IRS No.: 320426967 | State of Incorp.:DE | Fiscal Year End: 1231 (300 WASHINGTON ST.) (300 WASHINGTON ST.) Type: 8-K | Act: 34 | File No.: 001-33004 | Film No.: 211024741 SUITE 351 SUITE 351 SIC: 2834 Pharmaceutical preparations NEWTON MA 02458 NEWTON MA 02458 (844) 902-6100 Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (date of earliest event reported): June 17, 2021 ACER THERAPEUTICS INC. (Exact name of registrant as specified in its charter) Delaware 001-33004 32-0426967 (State or other jurisdiction of (Commission File Number) (IRS Employer Identification No.) incorporation) One Gateway Center, Suite 351 300 Washington Street Newton, Massachusetts 02458 (Address of principal executive offices) (Zip Code) Registrant’s telephone number, including area code: (844) 902-6100 N/A (Former name or former address, if changed since last report) Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: ☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) Securities registered pursuant to Section 12(b) of the Act: Title of Each Class Trading Symbol Name of Each Exchange on Which Registered Common Stock, $0.0001 par value per share ACER The Nasdaq Stock Market LLC Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐ Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Item 7.01. Regulation FD Disclosure Acer Therapeutics Inc. (the “Company”) has updated its Corporate Presentation that will be available on the Investor Relations page of the Company’s website at https://acertx.com/investor-relations and will be used at investor and other meetings. A copy of the updated Corporate Presentation is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference. The Company does not undertake to update this presentation. The information in Item 7.01 of this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be filed for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933 or the Exchange Act, except as shall be expressly set forth by specific reference in such filing. Item 9.01. Financial Statements and Exhibits. (d) Exhibits Exhibit No. Description 99.1 Acer Therapeutics Inc. Corporate Presentation, June 17, 2021. 2 Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. Dated: June 17, 2021 ACER THERAPEUTICS INC. By: /s/ Harry S. Palmin Harry S. Palmin Chief Operating Officer and Chief Financial Officer 3 Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Developing Therapeutics for the Treatment of Serious Rare and Life-Threatening Diseases with Significant Unmet Medical Needs Corporate Presentation June 17, 2021 Nasdaq: ACER Exhibit 99.1 Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Forward-lookingdevelopment,impact of competitive expected Statements products timeline This and and presentation technological commercial contains potential changes. “forward-looking of W anye disclaim of our productany statements” intent candidates. or obligation that involve We mayto substantialupdate not actually these risks forward-looking achieve and uncertainties the plans, statements carry for purposes out to the reflect intentions of the events safe or orharbor meet circumstances theprovided expectations bythat the exist orPrivate projections after Securities the date disclosed on Litigation which in thethey Reform forward-looking were Actmade. of 1995.You statements should All statements, review and youadditional other should than disclosuresnot statements place undue we of make historical reliance in our on facts, filings these included forward-lookingwith the in Securitiesthis presentation statements. and Exchange regarding Such statementsCommission, strategy, arefuture including based operations, on ourmanagement’ Quarterly timelines sReports currentfor clinical on expectations Form study 10-Q enrollment and and involve our or Annual regulatory risks Reportand uncertainties.actions, on Form or otherwise, 10-K. Actual You results future may accessandfinancial performance these position, documents could future diffor revenues,fer no materiallycharge projected at http://wwwfrom expenses, those .sec.govprojected regulatory. 2 in the submissions, forward-looking actions statements or approvals, as a result cash position,of many liquidityfactors, including,, prospects, without plans and limitation, objectives risks of and management uncertainties are associatedforward-looking with the statements. ability to Examplesproject future of such cash statements utilization include, and reserves but are needed not limited for contingent to, statements future relating liabilities to andthe potentialbusiness foroperations, our product the availabilitycandidates toof safelysufficient and resourceseffectively to treat fund diseases our various and toproduct be approved candidate for developmentmarketing; the programs commercial and toor meetmarket our opportunity business objectives of any of andour operationalproduct candidates requirements, in any thetarget fact indication that the results and any of territory;earlier studies our ability and trials to secure may notthe beadditional predictive capital of future necessary clinical to trialfund results, our various the protection product candidate and market development exclusivity programs; provided bythe our adequacy intellectual of our property capital, tothe support substantial our future costs andoperations diversion and of our management’ ability to successfullys attention andfund, resources initiate andwhich complete could resultclinical from trials pending and regulatory securities submissions litigation, risks for EDSIVO™related to the or drug our otherdevelopment products; and the the ability regulatory to protect approval our intellectual process, including property therights; timing our andstrategy requirements and business of regulatory focus; and actions, the and the Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Corporate Overview Acer Therapeutics is a pharmaceutical company that acquires, develops and seeks to commercialize therapies for serious rare and life-threatening diseases with significant unmet medical needs Offices: Newton, MA and Bend, OR Headcount: 23 Founded: December 2013 Public: September 2017 Cash as of March 31, 2021: $15.9M Plus, up to $20M of Development Payments per ACER-001 Collaboration and License Agreement with Relief Therapeutics dated March 19, 2021 Expected to have sufficient capital to fund current operations into mid-2022$ 3 ACER $ Excluding the planned EDSIVO™ and osanetant clinical trials Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document Leadership Team 4 ACER Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document 5IND Investment submission Highlights and clearance, Acer’s andpipeline agreement includes on fourSPA programs: $ Subject ACER-001to additional (sodium capital phenylbutyrate) for the treatment of various inborn errors of metabolism, including urea cycle disorders (UCDs) and Maple Syrup Urine Disease (MSUD) EDSIVO™ (celiprolol) for the treatment of vascular Ehlers-Danlos syndrome (vEDS) in patients with a confirmed type III collagen (COL3A1)
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  • Title Scaffold Hopping of Fused Piperidine-Type NK3 Receptor

    Title Scaffold Hopping of Fused Piperidine-Type NK3 Receptor

    Scaffold hopping of fused piperidine-type NK3 receptor Title antagonists to reduce environmental impact Yamamoto, Koki; Inuki, Shinsuke; Ohno, Hiroaki; Oishi, Author(s) Shinya Citation Bioorganic & medicinal chemistry (2019), 27(10): 2019-2026 Issue Date 2019-05-15 URL http://hdl.handle.net/2433/241057 © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.; The full- text file will be made open to the public on 15 May 2021 in Right accordance with publisher's 'Terms and Conditions for Self- Archiving'.; この論文は出版社版でありません。引用の際 には出版社版をご確認ご利用ください。; This is not the published version. Please cite only the published version. Type Journal Article Textversion author Kyoto University Scaffold hopping of fused piperidine-type NK3 receptor antagonists to reduce environmental impact Koki Yamamoto, Shinsuke Inuki, Hiroaki Ohno, Shinya Oishi* Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan *Corresponding Author: Shinya Oishi, Ph.D. Graduate School of Pharmaceutical Sciences Kyoto University Sakyo-ku, Kyoto, 606-8501, Japan Tel.: +81-75-753-4561; Fax: +81-75-753-4570, E-mail: [email protected] ABSTRACT Neurokinin-3 receptor (NK3R) plays a pivotal role in the release of gonadotropin-releasing hormone in the hypothalamus–pituitary–gonadal (HPG) axis. To develop novel NK3R antagonists with less environmental toxicity, a series of heterocyclic scaffolds for the triazolopiperazine substructure in an NK3R antagonist fezolinetant were designed and synthesized. An isoxazolo[3,4-c]piperidine derivative exhibited moderate NK3R antagonistic activity and favorable properties that were decomposable under environmental conditions.