DOCSLIB.ORG

Effects of Remote Microphone Hearing Aids (Rmhas) on Listening-In-Noise, Attention and Memory in School-Aged Children with Auditory Processing Disorder (APD)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Effects of Remote Microphone Hearing Aids (Rmhas) on Listening-In-Noise, Attention and Memory in School-Aged Children with Auditory Processing Disorder (APD) Effects of Remote Microphone Hearing Aids (RMHAs) on Listening-in-Noise, Attention and Memory in School-Aged Children with Auditory Processing Disorder (APD) ----- Georgios Stavrinos ----- A thesis submitted for the degree of Doctor of Philosophy ----- University College London Faculty of Brain Sciences Ear Institute ----- University College London September 2018 1 DECLARATION I, Georgios Stavrinos, confirm that the work presented in this thesis is my own. Where information has been derived from other sources, I confirm that this has been indicated in the thesis. 2 ACKNOWLEDGMENTS This has been one of the most challenging long-term projects I ever took on and it would not have been completed without the contribution, help, guidance, discussions and support from all the wonderful people mentioned here. I would first like to give warm thanks to the children, their parents and teachers who took part in my study. They were all very willing to contribute to the study and their patience and dedication is much appreciated. Of course, this project would not have been realised without the contribution from the funders of the project, GN ReSound and Action Medical Research. I am therefore grateful for their support. His support was constant for thirty-something years and without him I would not have been in the position to even start this PhD project. A lot of gratitude and love goes out to my father, Panagiotis Stavrinos, whom I had the misfortune to lose before he saw me complete this journey of which he was so supportive. The supervision and guidance of my supervisor, Professor Doris Bamiou, throughout this project have been nothing short of excellent. Her style of supervision fit exactly my style of work and this meant I was working in an environment where I felt motivated and confident. She has always been there to give the right advice, answer questions, listen, support and guide me whenever required. I have developed as a professional and as a person through her mentorship. I thank her for everything and feel extremely happy to be submitting this work having her name on it as my supervisor. The help of Professor Maria Chait, who served as my secondary supervisor, was invaluable and it shaped a large part of this work and my way of thinking, as well. She is scientist I look up to and her approach to research has taught me to be a better researcher myself and has definitely improved the quality of work in this thesis. I am grateful for her input and I thank her for everything I have learned from her. There are a number of people who practically contributed in various ways and varying degrees to the PhD project. They either discussed ideas, addressed concerns, gave me practical advice, read 3 parts of my work or offered tips on where to find answers. Debi Vickers, Ulrich Pomper, Ed Sohoglou, Vivian Iliadou, Irini Symeonidou, Orestis Georgiou, Nehzat Koohi, Hannah Cooper, Lindsey Edwards, Rajeev Mathew, Theo Petsas, Anahita Mehta, and Deborah Ridout, a thousand thanks! I also wish to give special thanks to Zelia Gregoriou who inspired me through her lectures during my undergraduate and played a big part in my love and interest for research and academia. And of course, last but not least, I am giving love and thanks to friends and relatives for the immense support and love who provided unconditionally to me throughout this PhD adventure. This PhD has taken me to many peaks and many valleys, but I am grateful to have had the following group of beautiful people be with me to help me up or cheer with me in all these moments, sometimes from distance (thank you skype, too!); Orestis, the other Orestis, Ianthi and Rallou, Giannis, Christiana and Teddy, my sister Constantia, Alexis, my nephews Nikolas and Ifigenia, huge thanks to Claudia who helped me immensely, Silvia, Andreas and Alexia, Irini and Christos (and Donald), Panos, Xenios and Eugenia, Giulia, Gyorgyi and Melinda, George and Maggie, Steph and Tom, Agata, Marta, Marios and Stella and Yiannakis Heracleous, and the rest of my family in London, Cyprus or Canada who have loved me, fed me and worried about me throughout this journey. 4 ABSTRACT Auditory Processing Disorder (APD) is characterised by poor Auditory Processing (AP) in the presence of normal hearing. Children with APD have poorer Speech-in-Noise (SIN) skills than their peers and are often reported to have poor attention and Auditory Working Memory (AWM). Management approaches include auditory training and Remote Microphone Hearing Aids (RMHAs). Research on the effects of RMHAs on children with APD is scarce. Some studies claim improvements in SIN performance following RMHA intervention, others suggest that AWM might not be assisted, while the system’s effect on attention remains unexplored. Also, the relationship between types of attention and AP skills has not been adequately explored and APD diagnostic criteria do not routinely include attention measures despite evidence linking the two. This thesis aims to address these gaps in the field through three studies. The first two studies examine the effects of RMHAs on measures of SIN and AWM but also on the novel measures of attention and spatial listening in children with APD using randomised controlled trials. The third study is the first to use correlation analyses to examine the relationship between AP skills and attention in a sample of only APD-diagnosed children. Furthermore, this study looked at a newly proposed APD diagnostic process which included measures of attention with the aim to better inform APD management. Overall, findings from the clinical trials did not find improvements in any of the attention tests following RMHA use for 6 months, while spatial listening was not negatively affected. In the final study, a strong relationship between divided attention and the dichotic digits test (an AP test) was revealed. Finally, the proposed diagnostic procedure provides useful information to the clinician in terms of management, which may potentially better address children’s needs. All findings are discussed in the context of the studies’ limitations. 5 IMPACT STATEMENT The results of the two clinical trials showed improved listening when using the Remote Microphone Hearing Aids (RMHAs) in some challenging acoustic situations in the classroom. We did not find any significant long-term improvement in attention, working memory, or listening-in-noise tests, and no adverse effect on spatial listening skills as documented on the listening-in-spatialised-noise test (for up to 6 months of use). These findings can inform clinical management of Auditory Processing Disorder (APD). For example, families who are recommended to use RMHAs with their child should be informed that while the RMHAs will make listening easier for the child, they will not have a direct impact on children’s attention, working memory, and listening-in-noise ability when not wearing the hearing aids. Therefore, additional interventions should be implemented to address such skills. At the same time, children who are diagnosed with Spatial Processing Disorder may use the RMHAs for at least up to 6 months (if the other auditory processing tests warrant a use of the device), as it will not negatively influence their spatial listening skills. The findings from the correlational study showed that divided auditory attention has a partial correlation with the dichotic digits test (a test already used to diagnose APD) in a sample of only APD-diagnosed children. This is a novel finding and it may have a direct impact on the APD diagnostic procedure. It is suggested that the two tests should be administered in combination with each other during APD assessments. This will help clinicians have a more complete profile of the patient’s dichotic listening skills and abilities in divided attention tasks. Furthermore, both the findings from the two clinical trials and the correlational study provide with a basis for future studies to build on. Firstly, future clinical trials should test RMHAs under longer intervention periods (of at least up to 12 months) to test long-term (unaided) benefits in attention, working memory, and listening-in-noise. Additionally, aided conditions (i.e. when RMHAs are used) should also be included in the research design to test whether they provide with an improvement in these outcome measures, compared to the unaided conditions. Based on limitations that were identified in the two clinical trials, it is proposed that future work using 6 RMHAs with APD-diagnosed children should follow these guidelines: not using other interventions alongside RMHAs unless part of the research protocol, verifying functionality of RMHAs, monitoring and reporting the total time the system was used during the study period, and administering a children’s questionnaire on levels of satisfaction in using the RMHA to be used as a control factor in the analysis. These guidelines aim to minimise bias, control confounding factors, while they also ensure uniformity across RMHAs trials on APD studies. Finally, based on the findings from the correlational study research should further explore the relationship between divided attention and the dichotic digits test in children with APD. 7 PUBLICATIONS AND PRESENTATIONS Published article resulting from this work 1. Original research article: Stavrinos, G., Iliadou, V.-M., Edwards, L., Sirimanna, T., & Bamiou, D.-E. (2018). The Relationship Between Types of Attention and Auditory Processing Skills: Reconsidering Auditory Processing Disorder Diagnosis. Frontiers in Psychology, 9(January), 1–13. doi:10.3389/fpsyg.2018.00034. Platform presentations resulting from this work 1. FM systems for APD, Auditory Processing Disorder Masterclass at the Ear Institute, UCL, London, 10th February 2016. 2. The effects of Personal Remote Microphone Hearing Aids on listening skills and auditory attention in children, aged 7-12, with Auditory Processing Disorder, GN ReSound Complex Needs Educational Events, a.
Load more

Recommended publications
  • British Cochlear Implant Group Meeting Maximising Potential
    Programme and Abstract Book British Cochlear Implant Group Meeting Maximising Potential Thursday 28th and Friday 29th April 2016 London Organising Committee Guys and St Thomas’ Hospital NHS Foundation Trust Hearing Implant Centre Royal National Throat, Nose and Ear Hospital Auditory Implant Programme Invited Faculty Professor Marc Marshark National Technical Institute for the Deaf, Rochester Institute of Technology Professor Christine Petit Genetics and Physiology of Hearing Laboratory, Institut Pasteur, Paris Professor Astrid Van Wieringen Department of Neuroscience, University of Leuven Professor Christophe Vincent Centre Hospitalier, Régional Universitaire de Lille Welcome Dear Colleagues, It is our great pleasure to welcome you to Kings Place and to the 26th British Cochlear Implant Group Meeting. This year we will be focusing on the theme ‘Maximising Potential’ with an interactive conference comprising of a wide range of professionals working in the field of auditory implants. It is with this interactivity in mind that we are hosting lively structured debates on current issues. Through the use of e-voting, we encourage audience participation in the hope of provoking thought and stimulating discussion. We are very fortunate to have with us over the two days such a high quality, international faculty and are very much looking forward to their contributions. Throughout the event e-Posters will be displayed in the exhibition area. Please visit this area and view them at your leisure. As well, please see the e-Poster programme for details of when authors will be presenting their work for 2 minutes at allocated times at e-Poster stations on Level -1. We would also encourage you to visit all of the exhibitors on the mezzanine level, as without their continued support we would not be able to run this conference.
    [Show full text]
  • Review 2011 1 Research
    LONDON’S GLOBAL UNIVERSITY ReviewHighlights 2011 2011 Walking on Mars © Angeliki Kapoglou Over summer 2011, UCL Communications held a The winning entry was by Angeliki Kapoglou (UCL Space photography competition, open to all students, calling for & Climate Physics), who was selected to serve as a member images that demonstrated how UCL students contribute of an international crew on the Mars Desert Research Station, to society as global citizens. The term ‘education for global which simulates the Mars environment in the Utah desert. citizenship’ encapsulates all that UCL does to enable Researchers at the station work to develop key knowledge students to respond to the intellectual, social and personal needed to prepare for the human exploration of Mars. challenges that they will encounter throughout their future careers and lives. The runners-up and other images of UCL life can be seen at: www.flickr.com/uclnews Contents Research 2 Follow UCL news www.ucl.ac.uk Health 5 Insights: a fortnightly email summary Global 8 of news, comment and events: www.ucl.ac.uk/news/insights Teaching & Learning 11 Events calendar: Enterprise 14 www.events.ucl.ac.uk Highlights 2011 17 Twitter: @uclnews UCL Council White Paper 2011–2021 YouTube: UCLTV Community 21 In images: www.flickr.com/uclnews Finance & Investment 25 SoundCloud: Awards & Appointments 30 www.soundcloud.com/uclsound iTunes U: People 36 http://itunes.ucl.ac.uk Leadership 37 UCL – London’s Global University Our vision Our values • An outstanding institution, recognised as one of the world’s
    [Show full text]
  • Annual Review 2012–13
    UCL DEPARTMENT OF PHYSICS AND ASTRONOMY PHYSICS AND ASTRONOMY ANNUAL REVIEW 2012–13 Physics and Astronomy ANNUAL REVIEW 2012–13 Contents 2 WELCOME 3 COMMUNITY FOCUS 4 The Wow Factor is Back! 5 Teaching Lowdown 6 Student Accolades 7 Doctor of Philosophy (PhD) 8 Career Profiles 10 Science in Action 11 Alumni Matters 12 ACADEMIC SHOWCASE 13 Staff Accolades 14 Academic Appointments 15 Portrait of Dr Hiranya Peiris 16 RESEARCH SPOTLIGHT 17 High Energy Physics (HEP) 19 Astrophysics (Astro) 21 Condensed Matter and Materials Physics (CMMP) 24 Atomic, Molecular, Optical and Positron Physics (AMOPP) 27 Biological Physics (BioP) 28 Research Statistics 32 Staff Snapshot Cover image: Display of a collision event in the ATLAS detector, where a Higgs boson candidate decays to two Z bosons, each of which decays to a muon and an anti-muon (red lines). ATLAS Experiment © 2012 CERN Inside cover image: Components in the undergraduate teaching laboratory used to explore practical thermodynamics. Credit: Paul Woods (UCL). http://paulwoods.4ormat.com Image page 3: The newly refurbished undergraduate library. Credit: Paul Woods (UCL) Image page 12: The Physics Building. Credit: Paul Woods (UCL) Image page 16: A random collection of textures taken from high-resolution, supercomputer simulations. Red indicates a positive twist in the topological charge density and blue a negative twist. Credit: V. Travieso and N. Turok Review edited by Katherine Heyworth, [email protected] Design © UCL Creative Media Services 1 WELCOME Welcome Welcome to another annual review of the activities of the UCL Department of Physics & Astronomy. Inside you will find items focusing on research highlights, as well as features on selected staff, students and events over the past year.
    [Show full text]
  • Subject Locations
    Subject Locations UCL Library Services, Gower St., London WC1E 6BT 020 7679 7793 E-mail: [email protected] Web: www.ucl.ac.uk/library . This guide aims to show where subjects are principally held in UCL’s libraries and collections, and libraries are indicated in bold type . Material held in our Stores is available on request and delivered daily during the week . Pers in the Catalogue is an abbreviation of Periodicals, and only more recent volumes are on the open shelves as many are now available online SUBJECT SITE A American History Main Library - 2nd floor, off South Corridor American Literature Main Library – North End, end of English collection Anatomy Science Library – 2nd floor, part of Medical Sciences collection Ancient History Main Library – 1st floor, off North corridor Anthropology Science Library - 2nd floor Archaeology Institute of Archaeology Library Architecture Bartlett Library Archive Studies Science Library - 1st floor Art Main Library – 1st floor, South End Art Periodicals - see catalogue for dates Main Library – 1st floor, South End & Stores Astronomy Science Library – 3rd floor, part of Physics collection Audiology UCL Ear Institute and Action on Hearing Loss Libraries at the Royal National Throat, Nose and Ear Hospital B Baltic States School of Slavonic & East European Studies Library Biochemical Engineering Science Library – 4th floor, part of Engineering collection Biochemistry Science Library - 2nd floor, part of Medical Sciences collection Biological Sciences Periodicals – see Science Library – 1st floor & Store
    [Show full text]
  • We Have an Exciting Opportunity for an ENT Trainee Or ENT Surgeon to Play a Key Role in a Ground Breaking First in Human Trial O
    UCL EAR INSTITUTE SENIOR or PRINCIPAL CLINICAL RESEARCH FELLOW (CL8 or 9) 0.8 FTE We have an exciting opportunity for an ENT trainee or ENT surgeon to play a key role in a ground breaking first in human trial of a novel therapy to treat hearing loss. The REGAIN project (REgeneration of inner hair cells with GAmma secretase INhibitors) is funded by the prestigious EU Horizon 2020 programme and aims to deliver a phase I/II study to test the safety and efficacy of a gamma secretase inhibitor in adults with mild to moderate sensorineural hearing loss. This innovative project is led by Prof Anne Schilder and Prof Shakeel Saeed, and will be conducted at the Royal National Throat Nose and Ear Hospital, in collaboration with the UCL Ear Institute and partner sites across Europe. We are looking for an enthusiastic and motivated senior ENT trainee, or a recently qualified ENT surgeon, to provide essential clinical support to the trial. She/he will be a key figure in the delivery of the trial, supported by research nurses and audiologists as part of the REGAIN team. In parallel to trial delivery, the post holder will be encouraged and supported to develop their own hearing research related to the trial, tailored to background and expertise. The postholder will therefore have a keen interest in translational research and developing a clinical academic career in the field of ENT, hearing and balance. She/he will be flexible, pro-active and able to work under own initiative. The appointment is either to the Senior Clinical Research Fellow or the Principal Clinical Research Fellow grade.
    [Show full text]
  • Hearing and Dementia
    J Neurol DOI 10.1007/s00415-016-8208-y NEUROLOGICAL UPDATE Hearing and dementia 1 1 1 1 Chris J. D. Hardy • Charles R. Marshall • Hannah L. Golden • Camilla N. Clark • 1,4 5,6 2,3,6 Catherine J. Mummery • Timothy D. Griffiths • Doris-Eva Bamiou • Jason D. Warren1,6 Received: 27 April 2016 / Revised: 13 June 2016 / Accepted: 14 June 2016 Ó The Author(s) 2016. This article is published with open access at Springerlink.com Abstract Hearing deficits associated with cognitive and conclude with a bedside approach to assessing and impairment have attracted much recent interest, motivated managing auditory dysfunction in dementia. by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing Keywords Hearing Á Auditory Á Dementia Á Alzheimer’s impairment present immense challenges in their own right, disease Á Frontotemporal dementia Á Progressive aphasia Á and their intersection in the auditory brain remains poorly Lewy body disease understood and difficult to assess. Here, we outline a clinically oriented, symptom-based approach to the assessment of hearing in dementias, informed by recent Introduction progress in the clinical auditory neuroscience of these diseases. We consider the significance and interpretation of Although hearing impairment is not generally regarded hearing loss and symptoms that point to a disorder of as a cardinal feature of dementia, hearing in patients auditory cognition in patients with dementia. We identify with dementia is a focus of growing clinical interest. key auditory characteristics of some important dementias Recent evidence suggests that hearing loss may predict or accelerate cognitive deterioration [1–3], and alter- ations of hearing may manifest as complex cognitive and behavioural symptoms relevant to the differential diag- nosis of dementias [4–10].
    [Show full text]
  • Clinical Lecturer in Paediatrics Job Description
    UCL SCHOOL OF LIFE AND MEDICAL SCIENCES UCL FACUTY OF POULATION HEALTH SCIENCES INSTITUTE OF CHILD HEALTH CLINICAL LECTURER IN PAEDIATRICS JOB DESCRIPTION INTRODUCTION The UCL Institute of Child Health (ICH) The mission of the UCL Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. This strategy has been informed by the insights gained from visits to six other internationally excellent children’s academic medical centres and by detailed discussions internally and with our external partners, including GODH, GOSH Children’s Charity, the wider UCL community, UCL Partners and funding bodies. The UCL Institute of Child Health, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. In 2013 ICH developed a new academic strategy which focuses on five scientific programmes: • Genetics and Genomic Medicine • Population, Policy and Practice • Developmental Biology and Cancer • Developmental Neurosciences • Infection, Immunity and Inflammation Four key principles underpin these programmes and the academic strategy: Interdisciplinarity. ICH will facilitate the best scientists, from all relevant academic and clinical disciplines, to work together to address fundamental questions to improve the health of children. Accelerating translation. ICH will support the rapid translation of findings from basic discoveries relevant to understanding of health and disease, to clinical studies, more directly aimed at improving the clinical care of children. We will also support “reverse translation” from observations in clinical and population studies to basic studies which address mechanisms of health and disease.
    [Show full text]
  • From Small Library Beginnings a Brief History of UCL Library Services
    UCL LIBRARY SERVICES From Small Library Beginnings A brief history of UCL Library Services An exhibition of material from UCL Special Collections 4 March – 13 December 2019 From Small Library Beginnings A brief history of UCL Library Services An exhibition of material from UCL Special Collections 4 March – 13 December 2019 #ucllibrariesexhib Preface UCL Library Services today comprises a modern, multi-site department with print collections numbering two million books, rich and diverse archives, extensive online resources and over 4,000 study spaces. The earliest collection, built up by the first Librarian, the Reverend Dr Francis Augustus Cox, numbered just 6,500 volumes in 1829. These were accommodated in what was known as the ‘Small Library’ at the southern end of the Wilkins Building. For some 40 years after 1831, with no formally appointed Librarian and limited funds, the collections grew mainly through donations and bequests. In the twentieth century the Library survived air raids and continued to grow, while in 1919 UCL’s School of Librarianship opened – precursor to the Department of Information Studies now proudly celebrating its centenary. This exhibition narrates the unique and absorbing history of UCL’s libraries. It highlights some of the spaces, collections and people that have been integral to their development, drawing on a selection of items from UCL Special Collections. Bookplate of Dr Ernest A Baker, Director of University College School of Librarianship 1919–34. (Opposite) 4 | From Small Library Beginnings Introduction | 5 Introduction Books about books; libraries The library is a growing organism about libraries All librarians have (or should have) the words of S R Ranganathan engraved on their hearts; some may even have them tattooed in other places.
    [Show full text]
  • Index of Libraries
    Attar_TEXT PROOF_04 12/05/2016 16:24 Page 543 Index of libraries Abbreviations: (NT) National Trust; (NTS) National Trust for Scotland Aberdeen Art Gallery and Museums, Barking and Dagenham Archives and Bristol Baptist College 23 James McBey Memorial Print Room Local Studies Centre 111 Bristol Central Library 23 and Art Gallery 447 Barnet Museum Reference Library 111 Bristol Museums, Galleries & Archives 24 Aberdeen University Library 447 Barnsley Archives and Local Studies 8 Britannia Royal Naval College 62 Aberdeenshire Libraries 493 Bateman’s (NT) 30 British Architectural Library 228 Aberystwyth University, the Hugh Owen Bath Central Library 8 British Dental Association 114 Library 505 Battersea Reference Library 111 British Falconers’ Club 334 Aberystwyth University, Thomas Parry Beckford’s Tower and Museum 10 British Geological Survey 89 Library 506 Bedales School 356 British Horological Institute 390 Abingdon School 3 Bedfordshire & Luton Archives Service 11 British Israel World Federation 16 Accrington Library 3 Bedfordshire Heritage Library 11 British Library 115 Action on Hearing Loss 255 Belfast Central Library 409 British Library of Political and Economic Admiralty Library 358 Belfast Harbour Commissioners 409 Science 202 Advocates’ Library 456 Belton House (NT) 75 British Medical Association 147 Aidan Heavey Public Library, Athlone 423 Bexley Local Studies and Archive Centre British Museum 147 Alexander Library of Ornithology 334 112 British Optical Association Library 154 Alfred Gillett Trust 384 Bible Society Library 38 British
    [Show full text]
  • Hearing and Dementia
    J Neurol (2016) 263:2339–2354 DOI 10.1007/s00415-016-8208-y NEUROLOGICAL UPDATE Hearing and dementia 1 1 1 1 Chris J. D. Hardy • Charles R. Marshall • Hannah L. Golden • Camilla N. Clark • 1,4 5,6 2,3,6 Catherine J. Mummery • Timothy D. Griffiths • Doris-Eva Bamiou • Jason D. Warren1,6 Received: 27 April 2016 / Revised: 13 June 2016 / Accepted: 14 June 2016 / Published online: 2 July 2016 Ó The Author(s) 2016. This article is published with open access at Springerlink.com Abstract Hearing deficits associated with cognitive and conclude with a bedside approach to assessing and impairment have attracted much recent interest, motivated managing auditory dysfunction in dementia. by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing Keywords Hearing Á Auditory Á Dementia Á Alzheimer’s impairment present immense challenges in their own right, disease Á Frontotemporal dementia Á Progressive aphasia Á and their intersection in the auditory brain remains poorly Lewy body disease understood and difficult to assess. Here, we outline a clinically oriented, symptom-based approach to the assessment of hearing in dementias, informed by recent Introduction progress in the clinical auditory neuroscience of these diseases. We consider the significance and interpretation of Although hearing impairment is not generally regarded hearing loss and symptoms that point to a disorder of as a cardinal feature of dementia, hearing in patients auditory cognition in patients with dementia. We identify with dementia is a focus of growing clinical interest. key auditory characteristics of some important dementias Recent evidence suggests that hearing loss may predict or accelerate cognitive deterioration [1–3], and alter- ations of hearing may manifest as complex cognitive and behavioural symptoms relevant to the differential diag- nosis of dementias [4–10].
    [Show full text]
  • Abstract Book
    Sponsored by TDT and NIDCD‐NIH Renaissance Blackstone Chicago Hotel, Chicago, IL Friday, October 16, 2015 8 AM – 6:30 PM Abstract Book (Arranged by last name of the Presenting Author) Affiliation index and Poster Name and affiliation affiliations for all Board # Notes index for ALL authors authors Abstract title Abstract text The perception of complex acoustic stimuli requires the evaluation of basic acoustic parameters like frequency, 12 Poster Nicole (1) Leibniz Effects of duration and intensity. Usually, these parameters are not judged in an absolute manner but in relation to preceding Angenstein (1) Institute for sequential sound segments e.g. the decision as to whether a given tone is soft or loud is made relative to a reference. As acoustic information of sound sequences unfolds over time, the evaluation of these sequences requires the storage of André Neurobiology comparison on information of individual segments until the judgment is finished and it requires a sequential update of this information. Sequential processing is suggested to mainly involve the left hemisphere. With functional magnetic resonance imaging Brechmann (1) Magdeburg the (fMRI) we investigated the effects of sequential comparison on the lateralization of processing in the human auditory cortex (AC) for direction of frequency modulations (FM), intensity and duration. For that we used a method that reveals lateralization differential hemispheric contribution to the processing based on an increase in activity by presenting additional noise of processing contralateral to monaurally presented task-relevant stimuli. The categorization of FM tones according to their FM direction strongly involves the right AC. However, the pairwise of different sequential comparison of this parameter led to an additional involvement of the left AC.
    [Show full text]
  • Non-Clinical Early Career Researchers ▪ Contribute to Academic Leadership Within IIT
    DIVISION OF INFECTION AND IMMUNITY Job Description Professor Grade: UCL Professorial Grade Department: Institute of Immunity and Location: Royal Free Campus, Transplantation, Division of Infection London and Immunity. Reports to: Professor Hans Stauss, Director of the Institute of Immunity and Transplantation The Division of Infection and Immunity at University College London is seeking an innovative scientist of international standing in immunology research for a professorial appointment at the Institute of Immunity and Transplantation (IIT). The appointee is expected to bring expertise in basic and translational immunology and undertake research that provides insights into the mechanisms of human disease which informs the development of novel immunotherapy approaches. We invite applications from outstanding investigators with a strong collaboration record and sustained high levels of research productivity. Eligible candidates should have expertise in immunology to complement extensive expertise in molecular and cellular immunology that currently exists at the IIT. We are particularly keen to attract those whose research can take advantage of the strong links between the IIT and the Royal Free NHS Foundation Trust, which provides excellent opportunities for translational immunology research relevant to human health. Applicants will have substantial experience in teaching and education and show a commitment to providing outstanding training for students, junior scientists and clinicians. The IIT is committed to an inclusive environment. We particularly welcome female applicants and applicants with diverse ethnic backgrounds. This is an established position within UCL. A competitive salary will be offered on the Professorial scale Context The IIT is a partnership between UCL and the Royal Free London NHS Foundation Trust and is supported by UCLPartners (UCLP).
    [Show full text]