DOCSLIB.ORG

1 Research Associate in Obesity and Cancer Risk

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
1 Research Associate in Obesity and Cancer Risk UCL RESEARCH DEPARTMENT OF EPIDEMIOLOGY AND PUBLIC HEALTH INSTITUTE OF EPIDEMIOLOGY AND HEALTH CARE RESEARCH ASSOCIATE IN OBESITY AND CANCER RISK INTRODUCTION An experienced epidemiological researcher is required to investigate associations between obesity and cancer risk using data from the English Longitudinal Study of Ageing ELSA. The post is located in the Health and Social Research Group in the Department of Epidemiology and Public Health, but will involve working closely with the Health Behaviour Research Centre. This post is funded for 12 months in the first instance Applicants should have a very strong academic background, skills and experience of analysing longitudinal cohort data, knowledge of the epidemiology of cancer, and excellent writing skills. Ability to contribute to statistical teaching and support would be an advantage. 1. BACKGROUND INFORMATION 1.1 The English Longitudinal Study of Ageing ELSA is a multi-disciplinary study of health, economic position, and social participation in a representative cohort of older men and women living in England. It is the only study of its kind in the UK and is unique in its depth of coverage of health, economic, psychological and social factors. ELSA researchers work within a multidisciplinary team spread over four institutions: UCL, the National Centre for Social Research (NatCen), the University of Manchester, and the Institute for Fiscal studies (IFS), and have close links with other ageing cohorts across the world, including HRS and SHARE. 1.2 The Research Department of Epidemiology and Public Health The Research Department of Epidemiology and Public Health is chaired by Professor Richard Watt, and houses roughly 180 staff across eleven research groups: namely; the Cancer Research UK Health Behaviour Research Centre (including Weight Concern), Central and Eastern Europe Research, Clinical Epidemiology, Dental Public Health, Genetic Epidemiology, Health and Social Surveys Research, Institute of Health Equity, International Centre for Life Course Studies in Society and Health, Leonard Cheshire Disability and Inclusive Development Centre, Psychobiology and Whitehall II Study. For an outline of current research projects in the Department please visit our website at http://www.ucl.ac.uk/epidemiology/. The Department offers an extensive graduate taught programme and provides a significant contribution to undergraduate teaching, as well as running several seminar series which all members of staff are encouraged to attend. 1.3. Institute of Epidemiology and Health Care 1 The Institute of Epidemiology & Health Care at UCL is part of the Faculty of Population Health Sciences within the UCL School of Life and Medical Sciences. It comprises six Research Departments - each of which is based at one or more sites across the UCL estate - as follows: CHIME http://www.chime.ucl.ac.uk Epidemiology and Public Health http://www.ucl.ac.uk/epidemiology/ Infection and Population Health http://www.ucl.ac.uk/iph/ Primary Care and Population Health http://www.ucl.ac.uk/pcph/ Department of Applied Health Research http://www.ucl.ac.uk/dahr/ MRC Lifelong Health & Ageing Unit at UCL http://www.nshd.mrc.ac.uk/ The Institute has an internationally competitive research programme focused on: • Understanding the determinants of health and disease across the life-course in populations and in patients in clinical settings, including the investigation of genetic, biological, behavioural, psychosocial and cultural processes; • Evaluating strategies for the prevention and treatment of physical and mental ill-health; • Monitoring and surveillance of health and health care nationally and internationally; • Carrying out innovative work on behaviour change and on the practice of primary care; • Developing and implementing new technologies in teaching and research in population health; • Teaching and capacity building in population health research and practice. • Applied health and health policy research The staff of the Institute is multidisciplinary, with expertise across the in clinical, public health, and primary care medicine, epidemiology, medical statistics, health psychology, sociology, health economics, public policy, information technology, genetics, physiology, and improvement science. As an Institute we have strong national and international interdisciplinary collaborations with a large portfolio of international research linked to the UCL Global Health Initiative. The Institute offers world-class education and training in a wide range of subjects including contributions to all years of the MBBS curriculum and an extensive portfolio of post graduate taught and research programmes. The Institute Director is Professor Andrew Steptoe Further information on IEHC can be found at: http://www.ucl.ac.uk/iehc/ 2. DUTIES OF THE POST Accountable to: Professor Andrew Steptoe, Director of the ELSA Group The post demands a strong quantitative research background and a keen interest in cancer; including ideally some knowledge of the links with obesity and weight change. Applicants must have a background in epidemiology and a sound understanding of behavioural, psychosocial, and environmental influences on cancer risk, experience of large longitudinal datasets, and strong statistical analysis skills. A combination of technical aptitude and good interpersonal skills is required, as is the ability to negotiate and co-ordinate with other organisations involved in the project. The ability to work effectively in a team and to deadlines, accuracy and an eye for detail, and self-motivation and initiative are all essential qualities. Based at: Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1 Key working relationships: Professor Andrew Steptoe, Professor Jane Wardle, other members of the ELSA group. Main purpose of post: To contribute to analyses of the bio-behavioural risks and consequences of cancer, using behavioural, psychosocial, and environmental data from the English Longitudinal Study of Ageing (ELSA). 2 Main duties and responsibilities • Preparing and analysing ELSA data on anthropometric variables, biomarkers, health behaviours and cancer diagnoses; • Preparation of manuscripts for publication in line with personal objectives agreed in the staff review process; • Publicising the project and disseminating findings to academic and non-academic users; • Liaising with and supporting members of the investigator team based in other institutions; • Participating in departmental and faculty seminars aimed at sharing research outcomes and building interdisciplinary collaboration within and outside the department; • Maintaining own continuing professional development; • Following and promoting UCL policies, including Equal Opportunities; • Maintaining awareness and observation of fire and health and safety regulations; • Carrying out any other duties commensurate with the grade and purpose of the post. Subject to the regulations of the funding bodies, appropriately qualified members of research staff will be expected to contribute to teaching and other departmental activities. At the present time this is estimated to amount to an absolute maximum of thirty contact teaching hours per annum. This job description reflects the present requirements of the post and, as duties and responsibilities change/develop, the job description will be reviewed and be subject to amendment in consultation with the postholder. 3 3. PERSON SPECIFICATION Qualifications E= Assessed by: A = application Essential I = interview D= Desirable Good first degree (1st or 2.1) E A MSc in a health-related subject D A PhD in quantitative social science or epidemiology OR equivalent research E A experience. If the degree has not yet been granted, the final accepted version of the thesis should have been submitted to the degree granting university by the time of starting. Skills/Abilities Excellent data management skills E A/I Excellent skills in analysis of large complex longitudinal datasets E A/I Excellent written communication skills E A/I Proven record of ability to manage time, prioritise workload and work to E A strict deadlines Organisational skills: attention to detail and good record keeping E A Ability to be flexible E A Self-motivation, the ability to work on own initiative and in a team E A Commitment to UCL’s policy of equal opportunity and the ability to work E A harmoniously with colleagues and students of all cultures and backgrounds Experience Multivariate data analysis in longitudinal data E A/I Quantitative survey methods E A/I Experience in research on health-related consequences of obesity E A/I Experience of research in cancer D A/I Publication in peer reviewed journals D A Working in a complex environment and achieving results D A/I Working in a multi-disciplinary team D A/I Knowledge and Aptitude Knowledge of the literature on determinants and consequence of obesity E I and weight loss Cancer epidemiology D I Statistical packages (Stata, SPSS, or equivalent) E A/I Information and information technology E A/I In addition to the person specification criteria, the successful candidate will need to meet UCL’s expectations of academic excellence, as outlined in ‘Excellence and the UCL community: a shared 4 endeavour’ (http://www.ucl.ac.uk/excellence/) (hard copies available on request). These will inform the candidate's induction, probation, and appraisal, in discussion with the Head of Department. 4. TERMS AND CONDITIONS OF SERVICE Salary Scale The salary will be on UCL Grade
Load more

Recommended publications
  • 2016-17 Department: UCL Medical School Faculty: Medical Sciences CONNECTED CURRICULUM
    UCL QUALITY REVIEW FRAMEWORK - ANNEX 6.1.3: ASER DEVELOPMENT & ENHANCEMENT PLAN Academic Session: 2016-17 Department: UCL Medical School Faculty: Medical Sciences CONNECTED CURRICULUM Last session, Departments were invited to discuss how they intended to begin their preliminary assessment of their taught provision by benchmarking each programme against the grid in the Connected Curriculum Enhancement Guide. Programmes were asked to evaluate and clearly state where the programme or cluster of similar programmes was benchmarked in relation to each dimension of the Connected Curriculum. In this section, Departments are asked to indicate the extent to which their programme(s) reflect each of the six dimensions, to highlight notable examples of good practice, and (in the Development and Enhancement plan below) to list up to six actions that the department/programme team will now take to enhance the programme(s) over the next two to three years. Departments will then be asked to review progress in relation to these actions in the Autumn 2019 ASER. The broad evaluation of the programme(s) as ‘Beginning’, ‘Developing’, ‘Developed’ or ‘Outstanding’ for each dimension will enable the Department/Programme Leader to track progress in relation to all six dimensions over time. It is intended to be a broadly agreed description of current practice in the programme(s) as a whole. General guidance on interpreting these terms is found on p6-7 of the Connected Curriculum online guide: https://www.ucl.ac.uk/teaching-learning/sites/teaching-learning/files/connected_curriculum_brochure_21_june_2017.pdf Departments may also find the ‘Twenty Questions’ on p10 helpful. If you have a large number of UG programmes in your department, a suggested approach is to use this form to provide a departmental summary of your programmes and then to identify those particular programmes which are excelling or which need more development by completing a form with a summary for each programme (or cluster of very similar programmes).
    [Show full text]
  • Projects Nominated in 2020 UCL Provosts Public Engagement
    Projects Nominated in 2020 UCL Provost's Public Engagement Awards Lead UCL Lead external Project Name UCL Department External Organisation Contact Contact A strengths-based approach to autism and employment: Insights, experiences, and Psychology and Human Development, UCL Anna Melissa best practice strategies from the Deutsche Bank UK autistic graduate internship Institute of Education – Centre for Research in Alex Wilson Deutsche Bank Romualdez programme Autism and Education Addressing Infrastructural Vulnerabilities: a participatory spatial intervention in the Andrea Rigon Development Planning Unit Joana Dabaj CatalyticAction refugee-hosting town of Bar Elias, Lebanon Evangelos Beatboxing After Laryngectomy UCL Institute of Education, Department of CCM Thomas Moors Shout at Cancer Himonides Education, Practice and Society, Institute of Building the evidence base for effective policy: the role of education in international Moses Oketch Education, Centre for Education and International Jess Atkinson Department for International Development (DFID) development Development (CEID) Ameenat Lola Childhood rare eyes disease: patient and public involvement and engagement UCL GOS Institute of Child Health Deirdre Leyden GOSH Patient and Public Involvement in Research Lead Solebo Civic Design CPD and Knowledge Exchange: Co-designing Neighbourhoods with Pablo Sendra The Bartlett School of Planning Leslie Barson Granville Community Kitchen Communities Collaborative City Planning Strategies Masters Module BPLN0033 Elena Besussi Bartlett School of
    [Show full text]
  • British Cochlear Implant Group Meeting Maximising Potential
    Programme and Abstract Book British Cochlear Implant Group Meeting Maximising Potential Thursday 28th and Friday 29th April 2016 London Organising Committee Guys and St Thomas’ Hospital NHS Foundation Trust Hearing Implant Centre Royal National Throat, Nose and Ear Hospital Auditory Implant Programme Invited Faculty Professor Marc Marshark National Technical Institute for the Deaf, Rochester Institute of Technology Professor Christine Petit Genetics and Physiology of Hearing Laboratory, Institut Pasteur, Paris Professor Astrid Van Wieringen Department of Neuroscience, University of Leuven Professor Christophe Vincent Centre Hospitalier, Régional Universitaire de Lille Welcome Dear Colleagues, It is our great pleasure to welcome you to Kings Place and to the 26th British Cochlear Implant Group Meeting. This year we will be focusing on the theme ‘Maximising Potential’ with an interactive conference comprising of a wide range of professionals working in the field of auditory implants. It is with this interactivity in mind that we are hosting lively structured debates on current issues. Through the use of e-voting, we encourage audience participation in the hope of provoking thought and stimulating discussion. We are very fortunate to have with us over the two days such a high quality, international faculty and are very much looking forward to their contributions. Throughout the event e-Posters will be displayed in the exhibition area. Please visit this area and view them at your leisure. As well, please see the e-Poster programme for details of when authors will be presenting their work for 2 minutes at allocated times at e-Poster stations on Level -1. We would also encourage you to visit all of the exhibitors on the mezzanine level, as without their continued support we would not be able to run this conference.
    [Show full text]
  • Gaseous “Nanoprobes” for Detecting Gas-Trapping Environments in Macroscopic Films of Vapor-Deposited Amorphous Ice DOI: 10.1063/1.5113505
    The University of Manchester Research Gaseous “nanoprobes” for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice DOI: 10.1063/1.5113505 Document Version Submitted manuscript Link to publication record in Manchester Research Explorer Citation for published version (APA): Talewar, S. K., Halukeerthi, S. O., Riedlaicher, R., Shephard, J., Clout, A., Rosu-Finsen, A., Williams, G. R., Langhoff, A., Johannsmann, D., & Salzmann, C. G. (2019). Gaseous “nanoprobes” for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice. The Journal of chemical physics, 151(13). https://doi.org/10.1063/1.5113505 Published in: The Journal of chemical physics Citing this paper Please note that where the full-text provided on Manchester Research Explorer is the Author Accepted Manuscript or Proof version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version. General rights Copyright and moral rights for the publications made accessible in the Research Explorer are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Takedown policy If you believe that this document breaches copyright please refer to the University of Manchester’s Takedown Procedures [http://man.ac.uk/04Y6Bo] or contact [email protected] providing relevant details, so we can investigate your claim. Download date:30. Sep. 2021 Gaseous ‘nanoprobes’ for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice Sukhpreet K. Talewar,a Siriney O.
    [Show full text]
  • Acoustic Immunosensing of Exosomes Using a Quartz Crystal Microbalance with Dissipation Monitoring
    Acoustic immunosensing of exosomes using a quartz crystal microbalance with dissipation monitoring. Jugal Suthar,y,z Edward S. Parsons,{ Bart W. Hoogenboom,{,x Gareth R. Williams,y and Stefan Guldin∗,z yUCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX, United Kingdom zDepartment of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom {London Centre for Nanotechnology, 17-19 Gordon Street, London, WC1H 0AH xDepartment of Physics and Astronomy, University College London, Gower Street, London, WC1E 6BT E-mail: [email protected] Abstract Exosomes are endocytic lipid-membrane bound bodies with potential to be used as biomarkers in cancer and neurodegenerative disease. The limitations and scarcity of current exosome characterisation approaches has led to a growing demand for trans- lational techniques, capable of determining their molecular composition and physical properties in physiological fluids. Here, we investigate label-free immunosensing, using a quartz crystal microbalance with dissipation (QCM-D), to detect exosomes by ex- ploiting their surface protein profile. Exosomes expressing the transmembrane protein 1 CD63 were isolated by size-exclusion chromatography from cell culture media. QCM-D sensors functionalised with anti-CD63 antibodies formed a direct immunoassay towards CD63-positive exosomes, exhibiting a limit-of-detection of 1.7x108 and 1.1x108 exosome sized particles (ESPs)/ ml for frequency and dissipation response respectively, i.e., clin- ically relevant concentrations. Our proof-of-concept findings support the adoption of dual-mode acoustic analysis of exosomes, leveraging both frequency and dissipation monitoring for use in diagnostic assays. Introduction Extracellular vesicles (EVs) are heterogenous, biomolecular structures enclosed by a lipid bilayer.
    [Show full text]
  • Review of UCL Medical School
    London regional review 2012–13 Review of UCL Medical School This visit is part of a regional review and uses a risk-based approach. For more information on this approach see http://www.gmc- uk.org/education/13707.asp. Review at a glance About the School Programme MBBS University UCL Medical School Years of course 6 Programme structure Year 1 – Fundamentals of clinical science 1 Year 2 – Fundamentals of clinical science 2 Year 3 – Scientific method in depth (iBSc) Year 4 – Integrated clinical care Year 5 – Life cycle Year 6 – Preparation for practice Number of students 1,969 (2011 MSAR) Number of LEPs UCL reported 196 clinical placements across 28 trusts or other providers, excluding GP placements. Local deanery London Deanery Last GMC visit 2004-5 QABME Outstanding actions None from last visit 1 About the visit Visit dates 22-23 November 2012 Sites visited UCL Medical School Areas of exploration MBBS Were any patient No safety concerns identified during the visit? Were any significant No educational concerns identified? Has further regulatory No action been requested via the responses to concerns element of the QIF? Summary 1 London has been chosen as the region for review in 2012-13 and all five London medical schools have been visited as part of this review. The north central regional visit team visited UCL Medical School (the School), a Division in the Faculty of Medical Sciences, University College London, in November 2012. 2 UCL is the third largest medical school in London with 1,969 students. The School has three main clinical campuses: Bloomsbury, the Royal Free and the Whittington.
    [Show full text]
  • Review 2011 1 Research
    LONDON’S GLOBAL UNIVERSITY ReviewHighlights 2011 2011 Walking on Mars © Angeliki Kapoglou Over summer 2011, UCL Communications held a The winning entry was by Angeliki Kapoglou (UCL Space photography competition, open to all students, calling for & Climate Physics), who was selected to serve as a member images that demonstrated how UCL students contribute of an international crew on the Mars Desert Research Station, to society as global citizens. The term ‘education for global which simulates the Mars environment in the Utah desert. citizenship’ encapsulates all that UCL does to enable Researchers at the station work to develop key knowledge students to respond to the intellectual, social and personal needed to prepare for the human exploration of Mars. challenges that they will encounter throughout their future careers and lives. The runners-up and other images of UCL life can be seen at: www.flickr.com/uclnews Contents Research 2 Follow UCL news www.ucl.ac.uk Health 5 Insights: a fortnightly email summary Global 8 of news, comment and events: www.ucl.ac.uk/news/insights Teaching & Learning 11 Events calendar: Enterprise 14 www.events.ucl.ac.uk Highlights 2011 17 Twitter: @uclnews UCL Council White Paper 2011–2021 YouTube: UCLTV Community 21 In images: www.flickr.com/uclnews Finance & Investment 25 SoundCloud: Awards & Appointments 30 www.soundcloud.com/uclsound iTunes U: People 36 http://itunes.ucl.ac.uk Leadership 37 UCL – London’s Global University Our vision Our values • An outstanding institution, recognised as one of the world’s
    [Show full text]
  • Annual Review 2012–13
    UCL DEPARTMENT OF PHYSICS AND ASTRONOMY PHYSICS AND ASTRONOMY ANNUAL REVIEW 2012–13 Physics and Astronomy ANNUAL REVIEW 2012–13 Contents 2 WELCOME 3 COMMUNITY FOCUS 4 The Wow Factor is Back! 5 Teaching Lowdown 6 Student Accolades 7 Doctor of Philosophy (PhD) 8 Career Profiles 10 Science in Action 11 Alumni Matters 12 ACADEMIC SHOWCASE 13 Staff Accolades 14 Academic Appointments 15 Portrait of Dr Hiranya Peiris 16 RESEARCH SPOTLIGHT 17 High Energy Physics (HEP) 19 Astrophysics (Astro) 21 Condensed Matter and Materials Physics (CMMP) 24 Atomic, Molecular, Optical and Positron Physics (AMOPP) 27 Biological Physics (BioP) 28 Research Statistics 32 Staff Snapshot Cover image: Display of a collision event in the ATLAS detector, where a Higgs boson candidate decays to two Z bosons, each of which decays to a muon and an anti-muon (red lines). ATLAS Experiment © 2012 CERN Inside cover image: Components in the undergraduate teaching laboratory used to explore practical thermodynamics. Credit: Paul Woods (UCL). http://paulwoods.4ormat.com Image page 3: The newly refurbished undergraduate library. Credit: Paul Woods (UCL) Image page 12: The Physics Building. Credit: Paul Woods (UCL) Image page 16: A random collection of textures taken from high-resolution, supercomputer simulations. Red indicates a positive twist in the topological charge density and blue a negative twist. Credit: V. Travieso and N. Turok Review edited by Katherine Heyworth, [email protected] Design © UCL Creative Media Services 1 WELCOME Welcome Welcome to another annual review of the activities of the UCL Department of Physics & Astronomy. Inside you will find items focusing on research highlights, as well as features on selected staff, students and events over the past year.
    [Show full text]
  • Ucl Medical School Internal Quality Review
    UCL MEDICAL SCHOOL INTERNAL QUALITY REVIEW Contents INTRODUCTION .....................................................................................................................................................4 Regulatory Framework.........................................................................................................................................4 Overview of Educational Organisational Structures ............................................................................................4 Overview of Educational Programmes.................................................................................................................5 SECTION 1. KEY DEVELOPMENTS......................................................................................................................7 1.1 Findings from previous review .......................................................................................................................7 1.2 Progress on implementation of the recommendations ................................................................................10 1.2.1 MBBS ....................................................................................................................................................10 1.2.2 Postgraduate Education ........................................................................................................................13 SECTION 2. STUDENTS, STAFF AND LEARNING RESOURCES.....................................................................15 2.1 Student Profile..............................................................................................................................................15
    [Show full text]
  • Annual Report 2011/2012 UCLB Projects As at 2012
    The Realisation of Research ANNUAL REPORT 2011/2012 UCLB PROJECTS AS AT 2012 2011/12 Turnover £8.7m £707,536 Funding for 21 Proof of Concept projects in 2011/12 £546,000 Investments made in 2011/12 360 Patent families as at 31 July 2012 370 Total licences as at 31 July 2012 53 Equity holdings as at 31 July 2012 38 New licences in 2011/12 44 New patents applied for in 2011/12 21 Drug discovery projects as at 31 July 2012 2 CONTENTS Messages 4 Our mission 6 What we do 7 Technology pipeline 8 Specialist expertise + Biomedical sciences 10 + Physical sciences, engineering, built environment and social sciences 12 + Product development & project management 14 + Social enterprise 16 + Partner Hospitals 18 Financials 20 Our Apps 22 Find out more 23 3 MESSAGE FROM CENGIZ TARHAN MANAGING DIRECTOR The realisation of research – UCL Business continues supporting UCL’s enterprise agenda The 2012 London Olympics delivered quite a show. UCL 2012 also provided an opportunity for a major £8 million Business (UCLB) spin out Space Syntax created the giant investment by UCL to recapitalise the company thus map of London’s street network as an iconic part of the reinforcing UCL’s support for UCLB. This bodes well, as opening ceremony used as our front cover photo. UCL’s strategic partnerships, including those with UCL Concerted effort within UCL to extend the new enterprise Partners – the Academic Health Science Centre, the strategy meant we can better identify, record, disseminate Francis Crick Institute and London’s Tech City – come on and increase the level of enterprise-related activity across stream.
    [Show full text]
  • GC-Targeted C8-Linked Pyrrolobenzodiazepine−Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models Khondaker M
    Article pubs.acs.org/jmc GC-Targeted C8-Linked Pyrrolobenzodiazepine−Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models Khondaker M. Rahman,† Paul J. M. Jackson,† Colin H. James,‡ B. Piku Basu,‡ John A. Hartley,§ Maria de la Fuente,‡ Andreas Schatzlein,‡ Mathew Robson,∥ R. Barbara Pedley,∥ Chris Pepper,⊥ Keith R. Fox,# Philip W. Howard,∇ and David E. Thurston*,† † Department of Pharmacy, Institute of Pharmaceutical Sciences, King’s College London, 150 Stamford Street, London SE1 9NH, United Kingdom ‡ UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, United Kingdom § Cancer Research UK Drug−DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, United Kingdom ∥ UCL Cancer Institute, University College London, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6BT, United Kingdom ⊥ Institute of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom # Centre for Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom ∇ Spirogen Ltd., QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom *S Supporting Information ABSTRACT: DNA binding 4-(1-methyl-1H-pyrrol-3-yl)- benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1- c][1,4]benzodiazepine (PBD) molecule to produce C8-linked PBD−MPB hybrids that can stabilize GC-rich DNA by up to 13-fold compared to AT-rich DNA. Some have subpicomolar IC50 values in human tumor cell lines and in primary chronic lymphocytic leukemia cells, while being up to 6 orders less cytotoxic in the non-tumor cell line WI38, suggesting that key DNA sequences may be relevant targets in these ultrasensitive cancer cell lines.
    [Show full text]
  • Teaching and Learning in Higher Education Ed
    Teaching and Learning in Higher Education Teaching ‘… an admirable testament to UCL’s ambition to foster innovative, evidence-based and thoughtful approaches to teaching and learning. There is much to learn from here.’— Professor Karen O’Brien, Head of the Humanities Division, University of Oxford ‘Research and teaching’ is a typical response to the question, ‘What are universities for?’ For most people, one comes to mind more quickly than the other. Most undergraduate students will think of teaching, while PhD students will think of research. University staff will have similarly varied reactions depending on their roles. Emphasis on one or the other has also changed over time according to governmental incentives and pressure. Davies and Norbert Pachler ed. Jason P. For some decades, higher education has been bringing the two closer together, to the point of them overlapping, by treating students as partners and nding ways of having them learn through undertaking research. Drawing on a range of examples from across the disciplines, this collection demonstrates how one research-rich university, University College London (UCL), has set up initiatives to raise the pro le of teaching and give it parity with research. It explains what staff and students have done to create an environment in which students can learn by discovery, through research- based education. ‘… an exemplary text of its kind, offering much to dwell on to all interested in advancing university education.’— Ronald Barnett, Emeritus Professor of Higher Education, University College London Institute of Education Dr Jason P. Davies is a Senior Teaching Fellow at the UCL Arena Centre.
    [Show full text]