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Review 2011 1 Research
LONDON’S GLOBAL UNIVERSITY ReviewHighlights 2011 2011 Walking on Mars © Angeliki Kapoglou Over summer 2011, UCL Communications held a The winning entry was by Angeliki Kapoglou (UCL Space photography competition, open to all students, calling for & Climate Physics), who was selected to serve as a member images that demonstrated how UCL students contribute of an international crew on the Mars Desert Research Station, to society as global citizens. The term ‘education for global which simulates the Mars environment in the Utah desert. citizenship’ encapsulates all that UCL does to enable Researchers at the station work to develop key knowledge students to respond to the intellectual, social and personal needed to prepare for the human exploration of Mars. challenges that they will encounter throughout their future careers and lives. The runners-up and other images of UCL life can be seen at: www.flickr.com/uclnews Contents Research 2 Follow UCL news www.ucl.ac.uk Health 5 Insights: a fortnightly email summary Global 8 of news, comment and events: www.ucl.ac.uk/news/insights Teaching & Learning 11 Events calendar: Enterprise 14 www.events.ucl.ac.uk Highlights 2011 17 Twitter: @uclnews UCL Council White Paper 2011–2021 YouTube: UCLTV Community 21 In images: www.flickr.com/uclnews Finance & Investment 25 SoundCloud: Awards & Appointments 30 www.soundcloud.com/uclsound iTunes U: People 36 http://itunes.ucl.ac.uk Leadership 37 UCL – London’s Global University Our vision Our values • An outstanding institution, recognised as one of the world’s -
Scientific Advisory Board
SCIENTIFIC ADVISORY BOARD ANNE B. YOUNG, MD, PHD CHAIR, SCIENTIFIC ADVISORY Board Chair Emerita, Department of Neurology Massachusetts General Hospital Distinguished Julieanne Dorn Professor of Neurology Harvard Medical School Royal College of Physicians, London American SCIENTIFICAcademy of Arts and Sciences ADVISORYNational Academy of MedicineBOARD ith funding from the Hereditary Disease Foundation and the National Institutes of Health, Anne WYoung has been involved in Huntington’s disease research for four decades. Anne participated in the Hereditary Disease Foundation’s Venezuela HD Project from 1981 until 2002 when the team could no longer return because of then Venezuelan President Hugo Chavez’s restrictions. In Venezuela, Anne focused on making accurate diagnoses, drawing blood for DNA, taking skin biopsies and helping collect tissue samples generously donated by the Venezuelan HD family members. Of the 20,000 neurological exams performed, Anne did many of them. Anne trained and mentored medical students and residents who joined the team. Anne and her late husband John B. (“Jack”) Penney, Jr. tested new models of how the basal ganglia controls movements. They based their theories on data from animal and postmortem human brain samples. They discovered, through clever experiments, how the basal ganglia are affected in Huntington’s and Parkinson’s diseases. The basal ganglia controls movement, reward, emotions and memory. Anne and Jack’s model suggested the design of therapies that would help both diseases. Anne was recruited in 1991 to Harvard Medical School and Massachusetts General Hospital as the hospital’s first female head of a department. She founded and designed the MassGeneral Institute for Neurodegenerative Diseases (MIND) in 2001 to accelerate the discovery of new and effective therapies for these disorders. -
Annual Report 2011/2012 UCLB Projects As at 2012
The Realisation of Research ANNUAL REPORT 2011/2012 UCLB PROJECTS AS AT 2012 2011/12 Turnover £8.7m £707,536 Funding for 21 Proof of Concept projects in 2011/12 £546,000 Investments made in 2011/12 360 Patent families as at 31 July 2012 370 Total licences as at 31 July 2012 53 Equity holdings as at 31 July 2012 38 New licences in 2011/12 44 New patents applied for in 2011/12 21 Drug discovery projects as at 31 July 2012 2 CONTENTS Messages 4 Our mission 6 What we do 7 Technology pipeline 8 Specialist expertise + Biomedical sciences 10 + Physical sciences, engineering, built environment and social sciences 12 + Product development & project management 14 + Social enterprise 16 + Partner Hospitals 18 Financials 20 Our Apps 22 Find out more 23 3 MESSAGE FROM CENGIZ TARHAN MANAGING DIRECTOR The realisation of research – UCL Business continues supporting UCL’s enterprise agenda The 2012 London Olympics delivered quite a show. UCL 2012 also provided an opportunity for a major £8 million Business (UCLB) spin out Space Syntax created the giant investment by UCL to recapitalise the company thus map of London’s street network as an iconic part of the reinforcing UCL’s support for UCLB. This bodes well, as opening ceremony used as our front cover photo. UCL’s strategic partnerships, including those with UCL Concerted effort within UCL to extend the new enterprise Partners – the Academic Health Science Centre, the strategy meant we can better identify, record, disseminate Francis Crick Institute and London’s Tech City – come on and increase the level of enterprise-related activity across stream. -
Clinical Review Huntington's Disease
CLINICAL REVIEW For the full versions of these articles see bmj.com Huntington’s disease Marianne J U Novak,1 2 Sarah J Tabrizi1 3 1National Hospital for Neurology Huntington’s disease is a devastating inherited and Neurosurgery, London neurodegenerative disease characterised by progressive motor, WC1N 3BG cognitive, and psychiatric symptoms. Patients may present 2Wellcome Trust Centre for Neuroimaging, UCL Institute of with any of these symptoms, and familiarity with the pheno- Neurology, London WC1N 3BG type is therefore important. Chorea and loss of balance are 3Department of Neurodegenerative early symptoms that patients notice, although families often Disease, UCL Institute of Neurology notice cognitive or personality changes before this. Correspondence to: S Tabrizi [email protected] The disease occurs in all racial groups but is most common in people of northern European origin. Its prevalence in the Cite this as: BMJ 2010;340:c3109 Western hemisphere is 7-10/100 000.w1 The mean age of onset doi: 10.1136/bmj.c3109 of symptoms is 40 years, but juvenile onset (<20 years) and older onset (>70 years) forms are well recognised. The Hunt- ington’s Disease Association (HDA) has records of 6161 adults with symptomatic Huntington’s disease and 541 children with juvenile Huntington’s disease (in England and Wales) at the Fig 1 | Statistical parametric map showing grey matter volume loss in patient groups compared with controls. Pre-A and time of writing. This is a conservative estimate of prevalence pre-B are premanifest Huntington’s disease gene carriers with because it includes only those people in contact with the HDA, estimated time to clinical disease onset greater than and less and it suggests that the true prevalence of the disease is higher than 10.8 years, respectively. -
Press Release
Press release Embargoed until 10.00 (GMT) Friday 9 May 2014 44 leading medical experts recognised for excellence in research 44 researchers from across the UK have been recognised for their contribution to the advancement of medical science by election to the Fellowship of the Academy of Medical Sciences. Academy Fellows are elected for excellence in medical research, for innovative application of scientific knowledge or for their conspicuous service to healthcare. The expertise of the new Fellows includes haematology, bioinformatics, immunology, psychiatry, biochemistry and health services provision. This year, fifteen (34%) of the new Fellows are women, compared to 23.2% of bioscience professors in the UK.* Professor Sir John Tooke PMedSci, President of the Academy of Medical Sciences said, “The Academy of Medical Sciences represents the excellence and diversity of medical science in the UK, and this is evident in the broad range of expertise demonstrated by this year’s new Fellows. They each bring a unique perspective which we will value immensely – from the industry experience of Fellows such as Professor Jackie Hunter to the policy knowledge of Baroness Finlay. Their election is a much deserved honour for the outstanding achievements they have shown throughout their careers. I know they will contribute greatly to the Academy, and I am delighted to welcome them all to the Fellowship.” Baroness Ilora Finlay of Landaff FMedSci is Professor of Palliative Medicine at Cardiff University, and a consultant at the Velindre Cancer Centre. In 2003, driven by her work with terminally ill lung cancer patients, she proposed a parliamentary bill to ban smoking in public buildings, and has worked with the government closely to advise on UK policies regarding organ donation, carbon monoxide poisoning, sunbed usage, bereavement in children and the care of prisoners. -
Research Assistant Information for Candidates
Research Assistant Information for Candidates Sainsbury Wellcome Centre for Neural Circuits and Behaviour at UCL CONTENTS Job Description………………………………………………………………………….……………………………3 About the Sainsbury Wellcome Centre .............................................................................................. 3 Background, Mission and Research Environment ............................................................................. 3 Sainsbury Wellcome Centre Scientific and Administrative Support ................................................... 4 About the Branco Laboratory ............................................................................................................ 4 The Role of Research Assistant ........................................................................................................ 4 Main Duties and Responsibilities ...................................................................................................... 5 Selection Criteria ........................................................................................................................................ 6 Contact Us .................................................................................................................................................. 7 How to Apply .............................................................................................................................................. 7 Terms of Appointment .............................................................................................................................. -
Histology Research Scientist (International Brain Laboratory) Information for Candidates
Histology Research Scientist (International Brain Laboratory) Information for Candidates Sainsbury Wellcome Centre for Neural Circuits and Behaviour at UCL CONTENTS Job Description………………………………………………………………………….……………………………3 About the International Brain Laboratory ........................................................................................... 3 About the Sainsbury Wellcome Centre .............................................................................................. 3 Background, Mission and Research Environment ............................................................................. 3 The Role of Histology Research Scientist (IBL) ................................................................................. 4 Main Duties and Responsibilities ...................................................................................................... 4 Selection Criteria ........................................................................................................................................ 6 Contact Us .................................................................................................................................................. 7 How to Apply .............................................................................................................................................. 7 Terms of Appointment ............................................................................................................................... 8 The Neuroscience Environment at UCL ................................................................................................... -
In This Issue Famous Neurologists Personal Perspectives
ISSN 1473-9348 VOLUME 10 ISSUE 4 SEPTEMBER/OCTOBER 2010 ACNRwww.acnr.co.uk ADVANCES IN CLINICAL NEUROSCIENCE & REHABILITATION In this issue Gérard Said – Vasculitic Neuropathy Famous Neurologists J van Gijn – Joseph Babinski 1857-1932 Hugh Rickards – How Helpful is it to Global Outcome to Treat Abnormal Movements in Tourette’s Syndrome? Personal Perspectives Parkinson’s Disease: personal experience NEWS REVIEW > CONFERENCE REPORTS > BOOK REVIEWS > JOURNAL REVIEWS > EVENTS DIARY Make a lasting impression By initiating early Azilect monotherapy, you can maintain your patients’ overall motor performance.1,2 So make a lasting impression – initiate Azilect monotherapy early in the course of Parkinson’s disease.3 Simple and effective when it matters Azilect ® 1mg tablets in patients treated concomitantly with antidepressants/SNRIs and POM Marketing Authorisation Number: 1mg tablets (28 pack size) Prescribing information (Please refer to the Summary of Product rasagiline. Avoid concomitant use with fluoxetine or fluvoxamine. EU/1/04/304/003 Marketing Authorisation Holder: Teva Pharma Characteristics (SmPC) before prescribing) Presentation: Tablets Leave at least five weeks between discontinuation of fluoxetine and GmbH, Kandelstr 10, D-79199 Kirchzarten Germany Date last revised: containing 1mg rasagiline (as the mesilate). Indication: Treatment initiation of treatment with rasagiline. Leave at least 14 days between December 2009. Further information available from: Lundbeck of idiopathic Parkinson’s disease as monotherapy or as adjunct to discontinuation of rasagiline and initiation of treatment with fluoxetine Limited, Lundbeck House, Caldecotte Lake Business Park, Caldecotte, levodopa in patients with end of dose fluctuations. Dosage and or fluvoxamine. Administer potent CYP1A2 inhibitors with caution. Milton Keynes, MK7 8LG administration: Oral, 1mg once daily taken with or without food Co-administration with dextromethorphan or sympathomimetics and with or without levodopa. -
Neuroscience and Mental Health UCL School of Life and Medical Sciences Creating Knowledge, Achieving Impact 3 PREFACE
Neuroscience and Mental Health UCL SCHOOL OF LIFE AND MEDICAL SCIENCES Creating knowledge, achieving impact 3 PREFACE UCL’s School of Life and Medical Cluster (GMEC) for which we lead in Sciences encompasses arguably the the field of rare diseases. Our growing greatest concentration of biomedical collaboration with our Bloomsbury science and population health neighbours, the London School of expertise in Europe. Our performance Hygiene and Tropical Medicine, is in the UK’s last Research Assessment fuelling exciting developments in Exercise was outstanding, and for most genetic epidemiology and pathogen key measures the School comfortably research. tops UK league tables. The breadth and quality of our In part because of UCL’s size and research creates almost unique organisational complexity, the scale opportunities. Our recent merger with of the School’s achievements is not the London School of Pharmacy adds always apparent. This publication, to our capacity in drug development, one of four, seeks to address this. formulation and adoption. Our highly Our recent reorganisation, with the productive links to the health service, Basic Life Sciences: creation of four new Faculties, has through UCL Partners, provides 1 ‘Discovery’ research, from been designed to create a more access to unmatched clinical expertise molecules to ecosystems. coherent structure, of which the and large patient groups. We are Faculty of Life Sciences, headed by fortunate to be partners in three Translation and the Dean, Professor Mary Collins, National Institute for Health Research 2 Experimental Medicine: is a clear example. But the School’s (NIHR) Biomedical Research Centres restructuring has also placed great and a new NIHR Biomedical Research Driving translation to emphasis on cross-Faculty interactions Unit in dementia. -
Compensation in Preclinical Huntington's Disease: Evidence from the Track-On HD Study
EBioMedicine 2 (2015) 1420–1429 Contents lists available at ScienceDirect EBioMedicine journal homepage: www.ebiomedicine.com Research Article Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study Stefan Klöppel a,b,c,1,SarahGregoryd,1, Elisa Scheller a,b,e,LoraMinkovaa,b,e, Adeel Razi d,f, Alexandra Durr g,h, Raymund A.C. Roos i, Blair R. Leavitt j, Marina Papoutsi k,G.BernhardLandwehrmeyerl, Ralf Reilmann m,n, Beth Borowsky o, Hans Johnson p, James A. Mills q, Gail Owen k, Julie Stout r, Rachael I. Scahill k, Jeffrey D. Long q,s, Geraint Rees d,t,⁎,1, Sarah J. Tabrizi k,⁎⁎,1, the Track-On investigators a Albert-Ludwigs-University Freiburg, University Medical Center, Division Freiburg Brain Imaging, Freiburg, Germany b Albert-Ludwigs-University Freiburg, University Medical Center, Department of Psychiatry and Psychotherapy, Freiburg, Germany c Albert-Ludwigs-University Freiburg, University Medical Center, Department of Neurology, Freiburg, Germany d Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK e Albert-Ludwigs-University Freiburg, Department of Psychology, Laboratory for Biological and Personality Psychology, Freiburg, Germany f Department of Electronic Engineering, N.E.D University of Engineering & Technology, Karachi, Pakistan g APHP Department of Genetics, Groupe Hospitalier Pitié-Salpêtrière, UPMC Université Paris VI UMR_S1127, Paris France h Institut du Cerveau et de la Moelle, INSERM U1127, CNRS UMR7225, UPMC Université Paris VI UMR_S1127, -
11-Ehdn-Newsletter-Oct2010
October 2010 · Issue 11 EHDN News EUROPEAN HUNTINGTON‘S DISEASE NETWORK CONTENT Click the Page EHDN 2010 1 HD Calendar 2010/2011 12 www.euro-hd.net Subscribe here to the EHDN Newsletter: Please go to the URL below and fill out the online form: http://www.euro-hd.net/html/network/ communication/newsletter Please send us your comments, sugges- tions and overall feedback: [email protected] Imprint: Editorial Board of the EHDN Newsletter: Prof. Gillian Bates (King’s College London School of Medicine, London, UK), Prof. Jenny Morton (University of Cambridge, Cambridge, UK), Dr. Diana Raffelsbauer (PharmaWrite, Giebelstadt, Germany), Dr. Jenny Townhill (Cardiff University, Cardiff, UK), Christiane Lohkamp (IHA, Stuttgart, Joseph Jankovic (Houston) and Bernhard Landwehrmeyer, Chairman of EHDN Germany), Gabriele Stautner (Artifox Communication Design, Ulm, Germany). © 2010 European Huntington’s Disease Net- FEATURE ARTICLE work, Chairman Prof. G.B. Landwehrmeyer, Oberer Eselsberg 45/1, 89081 Ulm, Germany By Diana Raffelsbauer, Freelance Medical Writer, Pharmawrite, Germany The information contained in this newsletter is subject to the European HD Network Liability Disclaimer, which can be found at EHDN 2010 http://www.euro-hd.net/html/disclaimer. –Please consult a doctor for medical advice– The largest meeting ever devoted to Except as otherwise noted, this work is licensed under the Creative Commons Huntington’s disease Attribution-No Derivative Works 3.0 Unported License. The European Huntington’s Disease Network (EHDN) invited its members to attend the 6th EHDN Plenary Meeting (EHDN 2010) in Prague. With more than 650 participants, this was the largest scientific meeting ever dedicated exclusively to Huntington’s disease (HD). -
A Physician's Guide to the Management of Huntington's Disease
A Physician’s Guide to the Management of Huntington’s Disease Third Edition Martha Nance, M.D. Jane S. Paulsen, Ph.D. Adam Rosenblatt, M.D. Vicki Wheelock, M.D. Front Cover Image: Volumetric 3 Tesla MRI scan from an individual carrying the HD mutation, with full manifestation of the disease. The scan shows atrophy of the caudate. Acknowledgements: Images were acquired as part of the TRACK-HD study of which Professor Sarah Tabrizi is the Principal Investigator. TRACK-HD is funded by CHDI Foundation, Inc., a not-for-profit organization dedicated to funding treatments for Huntington¹s disease. A Physician’s Guide to the Management of Huntington’s Disease Third Edition Martha Nance, M.D. Director, HDSA Center of Excellence at Hennepin County Medical Center Medical Director, Struthers Parkinson’s Center, Minneapolis, MN Adjunct Professor, Department of Neurology, University of Minnesota Jane S. Paulsen, Ph.D. Director HDSA Center of Excellence at the University of Iowa Professor of Neurology, Psychiatry, Psychology, and Neuroscience, University of Iowa Carver College of Medicine, Iowa City, IA Principal Investigator, PREDICT-HD, Study of Early Markers in HD Adam Rosenblatt, M.D. Director, HDSA Center of Excellence at Johns Hopkins, Baltimore Maryland Associate Professor of Psychiatry, and Director of Neuropsychiatry, Johns Hopkins University School of Medicine Vicki Wheelock, M.D. Director, HDSA Center of Excellence at University of California Clinical Professor, Neurology, University of California, Davis Medical Center, Sacramento, CA Site Investigator, Huntington Study Group Editors: Debra Lovecky Director of Programs, Services & Advocacy, HDSA Karen Tarapata Designer: J&R Graphics Printed with funding from an educational grant provided by 1 Disclaimer The indications and dosages of drugs in this book have either been recommended in the medical literature or conform to the practices of physicians’ expert in the care of people with Huntington’s Disease.