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Curriculum Vitae Dr. Justin S. Miller CURRICULUM VITAE DR. JUSTIN S. MILLER Associate Professor 3324 Dandelion Trail Department of Chemistry Canandaigua, NY 14424 Hobart and William Smith Colleges Phone: (315) 781-3884 Geneva, NY 14456 Email: [email protected] Web: http://campus.hws.edu/academic/popup.asp?id=366 EDUCATION Sloan-Kettering Institute for Cancer Research Postdoctoral Fellow (2001 – 2004), Advisor: Dr. Samuel J. Danishefsky Massachusetts Institute of Technology Ph.D., Organic Chemistry (2001), Advisors: Dr. Daniel S. Kemp, Dr. Scott C. Virgil • Dissertation: “I. Efforts towards the Synthesis of CP-263,114. II. On Solubilized, Spaced Polyalanines and Amino Acid -Helix Propensities.” • Graduate Student Teaching Award (1998) Princeton University A.B., Chemistry (1995), Advisor: Dr. Jeffrey Schwartz • Senior thesis: “The Reduction of Methyl Cinnamate by Titanocene Borohydride: A Mechanistic Study.” ACADEMIC APPOINTMENTS Associate Professor, organic chemistry, Hobart and William Smith Colleges (HWS) (2010 – present; Chair 2013 – present) Assistant Professor, organic chemistry, Hobart and William Smith Colleges (HWS) (2004 – 2010) Research interests • Peptide and protein synthetic methodology • Organic synthesis of bioactive molecules • Principles of bioorganic chemistry Courses taught • Introductory and intermediate organic chemistry, including laboratory • Bonding with Food: The Chemistry of Food Preparation, Production, and Policy • Advanced organic chemistry • Introductory general chemistry, including laboratory EXTERNAL GRANT FUNDING co-PI, NSF – Transforming Undergraduate Education in STEM (NSF-TUES) (2011 – 2014) • ($180,000) “NSF-TUES: Transforming Cell Biology and Organic Chemistry through Incorporation of the HDACi Cancer Therapeutic Laboratory Project” PI, National Institutes of Health Academic Research Enhancement Award (NIH-AREA) (2010 – 2014) • ($355,523) “NIH-AREA: Synthesis of Anticancer HDAC Inhibitor Natural Products and Analogs” PI, National Science Foundation Major Research Instrumentation (NSF-MRI) Award (2007 – 2010) • ($342,000) “MRI: Acquisition of an NMR Spectrometer to Advance Active Undergraduate Education and Research Programs” Research Corporation Cottrell College Science Award (2005 – 2009) • ($40,218 + $15,000 institutional matching) “Solid-Phase Synthesis of Cyclic, Cysteine- Containing Natural Products and Analogues” Camille and Henry Dreyfus Start-up Award (2004 – 2009) • ($30,000) “Solid-Phase Synthesis of Peptide Bioconjugates and Peptidic Natural Products” U.S. Army Prostate Cancer Research Postdoctoral Training Award (2003 – 2004) • ($98,000) “Toward a Diagnostic Immunoassay Specific for Prostate Cancer: Chemical Synthesis of Homogeneous N-Linked Prostate Specific Antigen Glycopeptides” Page 1 of 7 CURRICULUM VITAE DR. JUSTIN S. MILLER PUBLICATIONS (undergraduate coauthors in bold) (13) N. A. Calandra, Y. L. Cheng, K. A. Kocak, and J. S. Miller. “Total Synthesis of Spiruchostatin A via Chemoselective Macrocyclization using an Accessible Enantiomerically Pure Latent Thioester.” Org. Lett. 2009, 11(9), 1971-1974. (12) R. J. Moreau, C. R. Schubert, K. A. Nasr, M. Török, J. S. Miller, R. J. Kennedy, and D. S. Kemp. “Context-Independent, Temperature-Dependent Helical Propensities for Amino Acid Residues.” J. Am. Chem. Soc. 2009, 131(36), 13107-13116. (11) V. Y. Dudkin, J. S. Miller, A. S. Dudkina, C. Antczak, D. A. Scheinberg, and S. J. Danishefsky. “Toward a Prostate Specific Antigen-Based Prostate Cancer Diagnostic Assay: Preparation of Keyhole Limpet Hemocyanin-Conjugated Normal and Transformed Prostate Specific Antigen Fragments.” J. Am. Chem. Soc. 2008, 130(41), 13598-13607. (10) G. E. Job, R. J. Kennedy, Heitmann, B., J. S. Miller, S. M. Walker, and D. S. Kemp. “Temperature- and Length-Dependent Energetics of Formation for Polyalanine Helices in Water: Assignment of wAla(n,T) and Temperature-Dependent CD Ellipticity Standards.” J. Am. Chem. Soc. 2006, 128(25), 8227-8233. (9) J. D. Warren, J. S. Miller, S. J. Keding, and S. J. Danishefsky. “Toward Fully Synthetic Glycoproteins by Ultimately Convergent Routes: A Solution to a Long-Standing Problem.” J. Am. Chem. Soc. 2004, 126, 6576-6578. (8) V. Y. Dudkin, J. S. Miller, and S. J. Danishefsky. “Chemical Synthesis of Normal and Transformed PSA Glycopeptides.” J. Am. Chem. Soc. 2004, 126, 736-738. (7) J. S. Miller, V. Y. Dudkin, G. J. Lyon, T. W. Muir, and S. J. Danishefsky. “Toward Fully Synthetic N-Linked Glycoproteins.” Angew. Chem. Int. Ed. 2003, 42(4), 431-434. (6) V. Y. Dudkin, J. S. Miller, and S. J. Danishefsky. “A Concise Route to the Core Pentasaccharide of N-Linked Glycoproteins.” Tetrahedron Lett. 2003, 44(9), 1791-1793. (5) P. Wallimann, R. J. Kennedy, J. S. Miller, W. Shalongo, and D. S. Kemp. “Dual Wavelength Parametric Test of Two-State Models for Circular Dichroism Spectra of Helical Polypeptides: Anomalous Dichroic Properties of Alanine-Rich Peptides.” J. Am. Chem. Soc. 2003, 125(5), 1203- 1220. (4) J. S. Miller, R. J. Kennedy, and D. S. Kemp. “Solubilized, Spaced Polyalanines: A Context-Free System for Determining Amino Acid -Helix Propensities.” J. Am. Chem. Soc. 2002, 124(6), 945- 962. (3) W. Maison, R. J. Kennedy, J. S. Miller, and D. S. Kemp. “C-Terminal Helix Capping Propensities in a Polyalanine Context for Amino Acids Bearing Nonpolar Aliphatic Side Chains.” Tetrahedron Lett. 2001, 42(30), 4975-4977. (2) J. S. Miller, R. J. Kennedy, and D. S. Kemp. “Short, Solubilized Polyalanines Are Conformational Chameleons: Exceptionally Helical If N- and C-Capped with Helix Stabilizers, Weakly to Moderately Helical If Capped with Rigid Spacers.” Biochemistry, 2001, 40(2), 305-309. (1) J. M. Schmitt, G. X. Zhou, and J. Miller. “Measurement of blood hematocrit by dual-wavelength near-IR photoplethysmography.” Proc. SPIE-Int. Soc. Opt. Eng. 1992, 1641 (Physiol. Monit. Early Detect. Diagn. Methods), 150-61. Page 2 of 7 CURRICULUM VITAE DR. JUSTIN S. MILLER PATENTS (2) S. J. Danishefsky, V. Y. Dudkin, J. S. Miller, D. A. Scheinberg, and C. Antczak. “Preparation of normal and transformed PSA glycopeptide conjugates for diagnostic and therapeutic applications.” U.S. Pat. Appl. Publ. 2006, 124 pp. Patent application cont.-in-part of Appl. No. PCT/03US/38453. (1) S. J. Danishefsky, V. Y. Dudkin, and J. S. Miller. “Preparation of Prostate Specific Antigens and Conjugates of Diagnosis and Treatment of Cancer.” PCT Int. Appl. 2004, 257 pp. Patent application: WO 2003-US38453. PRESENTATIONS (undergraduate coauthors in bold) (22) G. B. Shelkey, W. S. Perkins, X. Zang, L. Peraro, S. L. Cramer, J. N. Garofalo, T. R. Blum, and J. S. Miller. “Cyclic, cysteine-containing depsipeptide synthesis via latent thioester key intermediates.” 43rd ACS National Organic Chemistry Symposium, Seattle, WA, Jun 23-27, 2013. (21) W. J. Bowyer, J. S. Miller, and C. Forbes. “Kitchen as laboratory: Two courses at two very different levels.” Abstracts of Papers, 245th ACS National Meeting, New Orleans, LA, Apr 7-11, 2013, CHED-1704. (oral) (20) L. Peraro and J. S. Miller. “Incorporating original research into the organic teaching laboratory: The HDACi Cancer Therapeutic Laboratory Project.” Abstracts of Papers, 245th ACS National Meeting, New Orleans, LA, Apr 7-11, 2013, CHED-1614. (oral) (19) J. S. Miller and G. L. Sacks. “Chemistry of Cajun Cooking Competition.” Abstracts of Papers, 245th ACS National Meeting, New Orleans, LA, Apr 7-11, 2013, CHED-83. (18) X. Zang, L. Peraro, H. K. Shah, G. B. Shelkey, M. A. Mahajan, and J. S. Miller. “Solid-phase synthesis of depsipeptidic potential anticancer compounds using latent thioesters.” Abstracts of Papers, 245th ACS National Meeting, New Orleans, LA, Apr 7-11, 2013, ORGN-204. (17) W. S. Perkins, X. Zang, L. Peraro, H. K. Shah, N. M. Zanghi, and J. S. Miller. “Solid-Phase Synthesis of Depsipeptidic Anticancer Natural Products and Analogs via Improved Latent Thioester Mediated Solid-Phase Methodology.” Abstracts of Papers, 243rd ACS National Meeting, San Diego, CA, Mar 25-29, 2012, ORGN-610. (16) D. M. Wholly, W. S. Perkins, H. K. Shah, and J. S. Miller. “Solid-Phase Synthesis of Depsipeptidic Anticancer Natural Products and Analogs.” Abstracts of Papers, 241st ACS National Meeting, Anaheim, CA, Mar 27-31, 2011, ORGN-163. (15) T. R. Blum, H. K. Shah, X. Zang, W. S. Perkins, A. R. Korn, D. M. Wholly, and J. S. Miller. “Solution- and Solid-Phase Synthesis of Potential Anticancer HDAC Inhibitors.” Abstracts of Papers, 240th ACS National Meeting, Boston, MA, Aug 22-26, 2010, ORGN-937. (14) J. S. Miller. “Responsive Lecturing: Keeping the Tradition and Improving the Pedagogy.” HWS New Faculty Orientation, Aug 25, 2009. (invited lecture) (13) D. M. Wholly, T. R. Blum, J. A. Walkley, K. A. Hlavac, and J. S. Miller. “Total Synthesis of Cysteine-Containing, Depsipeptidic Natural Products in Solution and on the Solid Phase via Chemoselective Macrocyclization Using Latent Thioester Solid-Phase Linkers.” Abstracts of Papers, 238th ACS National Meeting, Washington, D.C., Aug 16-20, 2009, ORGN-785. (12) J. S. Miller. “Fighting Cancer One Molecule at a Time? A Total Synthesis of Spiruchostatin A.” Illinois Wesleyan University Natural Science Colloquium Series, Apr 3, 2009. (invited lecture) (11) J. S. Miller. “Lecturing Techniques that Engage Students.” HWS Faculty Institute: Teaching Practices in Context, Jan 15, 2009. (invited lecture) Page 3 of 7 CURRICULUM VITAE DR. JUSTIN S. MILLER (10) J. S. Miller. “Fighting Cancer One Molecule at a Time? A Total Synthesis of Spiruchostatin A.” Ithaca College Chemistry Department Seminar, Dec 9, 2008. (invited lecture) (9)
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  • 2008 Umsl Chemist
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