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The Cognitive Enhancement Recearch Institute’s Down’s Syndrome Collection Thank you for downloading the Down’s Syndrome Collection from the Cognitive Enhancement Research Institute. The information in this collection is very advanced and quite powerful. Many people will have difficulty understanding it all on first reading. Don’t worry. You can read it twice, or thrice — as many times as you wish. Each time that you re-read it, more will make sense. About the Contents The articles, editorials, updates, sidebars and questions-and-answers (Q&As) in this collection were originally published in the pages of Smart Drug News (from 1992 through 1997) and Smart Life News (from 1997 to the present). They are arranged chronologically. The first article in the collection, a feature article on Down’s syndrome written by Ward Dean, M.D. (CERI’s Medical Advisor) and Steven Wm. Fowkes (CERI’s Executive Director) was published on Valentine’s Day in 1994. The latest article was published in 2001. This collection consists of 44 items drawn from 26 newsletters. Only the newsletter pages with information on Down’s syndrome are included. Five of the items are full-length feature articles (typically 4-7 pages each). There are also 28 Q&As (one or two pages each), nine sidebars (one page each), an editorial (one page), a notice of a television show (one page) and an update on a conference (one page). The latter two items are now of historical interest only, but are included anyway, in the interest of completeness. The information in the former items is still as valid and relevant today as when first published. Navigating the Collection When using Acrobat Reader to view the Down’s Syndrome Collection, you can access each individual page by using the “thumbnails” tab, which will display all the pages in the document by their “collection” page number. The “thumbnails” feature, if not readily apparent, can be accessed using the menu options in your software. Please note that the collection page numbers do not appear on the actual pages themselves. The page numbers on the bottom of each page are those that appeared on the original newsletters. These are based on a volume- issue-and-page numbering system. To help keep these different systems straight, the table of contents (see next page), lists both page-numbering systems — side by side. If you choose to print these pages, you may wish to write the collection page numbers on each page in a brightly colored ink to make it easier to find your way around. Every page in this collection will have something relating to Down’s syndrome on it. However, because these are whole pages collected from newsletters, many pages will have lead-in or follow-up text that deals with some other subject covered by CERI. You may ignore this unrelated information, or consider it a bonus, whichever you prefer. If you see something interesting, the volume, issue and date information in the footer on each page will allow you to find and obtain the back issue from which it was collected. Subscriptions If you want access to ongoing information of this kind, subscribe to Smart Life News. You can subscribe online with a credit card at http://www.smartlifenews.com/subscriptions.html, or you can send a personal check or money order to CERI, P.O. Box 4029-d4, Menlo Park, California, 94026-4029 USA. You are also welcome to call us at 650-321-CERI. Be sure to mention “d4" on the address or in your phone call, as there is a $20 discount that you will get on the price of your subscription. The discounted subscription price is just $59 for US addresses, $62 for Canadian or Mexican addresses, and $74 for international addresses for ten issues of Smart Life News. Please keep in mind that not every issue will deal with Down’s syndrome. Historically, 26 of 72 issues (36%) have had Down’s syndrome content, but the ratio has risen to approximately 50% in recent issues (volumes 6, 7 and 8). Thanks again for downloading our Down’s Syndrome Collection. I hope you have an enlightening reading experience. Steven Wm. Fowkes Executive Director Table of Contents Acrobat™ Page Newsletter Footer-Page Brief Description of Content 1 (none) Title Page and Description 2 (none) Table of Contents and Copyright Page (this page) 3 SDN Vol. 2, No. 10, p. 1-7 Feature Article: Smart Drugs and Down’s Syndrome 7 p. 5 Sidebar: Dr. Lee-Benner Visits the Warner House Clinic 10 SDN Vol. 3, No. 4, p. 1-6 Feature Article: An Interview with Dixie Lawrence 16 SDN Vol. 3, No. 7, p. 9-10 Q&A: Report on TNI, Turkel and Warner inquiry 16 p. 10 Q&A: Appreciation for Dixie Lawrence Interview 18 SDN Vol. 3, No. 8, p. 12 Sidebar: Day One Segment Scheduled for January 19 SDN Vol. 3, No. 9, p. 9 Editorial: Dealing with Your Doctor 20 SDN Vol. 4, No. 6, p. 12 Update: Down’s Syndrome Symposium 21 SDN Vol. 4, No. 9, p. 9-10 Q&A: Two questions about piracetam and excitotoxicity? 23 SDN Vol. 4, No. 10, p. 1-6 Feature Article: Antioxidant Intervention in Down’s Syndrome 24 p. 2 Sidebar: What are Free Radicals? 25 p. 3 Sidebar: The Recycling of Glutathione 29 SDN Vol. 5, No. 1, p. 1-5 Feature Article: Nutritional Intervention in Down’s Syndrome 30 p. 2 Sidebar: The SAM Cycle 34 SDN Vol. 5, No. 1, p. 11 Q&A: Will piracetam affect my daughter’s lipid metabolism? 35 SDN Vol. 5, No. 3, p. 6-7 Q&A: TNI and piracetam attack dosing? 36 p. 7 Q&A: Hard to find piracetam information? 36 p. 7-8 Q&A: What is the best age to start piracetam? 38 SDN Vol. 5, No. 3, p. 9-10 Q&A: Melatonin as Glutathione Stimulant? 40 SDN Vol. 5, No. 8, p. 8-9 Q&A: Down with Down’s? 42 SDN Vol. 5, No. 8, p. 10 Q&A: Piracetam and Seizures? 42 p. 10-11 Q&A: Down’s Syndrome Surgery and Nutritional Therapy (TNI)? 43 p. 11 Q&A: Splitting Piracetam Capsules? 44 SDN Vol. 5, No. 9, p. 1-8 Feature Article: The Case for Piracetam in Down’s Syndrome 45 p. 2 Sidebar: The Fiona Study 47 p. 4 Sidebar: Senility Prescription Practices 49 p. 6 Sidebar: Piracetam & Sickle Cell Anemia (& Angelman Syndrome) 52 SDN Vol. 5, No. 10, p. 8-9 Q&A: Down’s Syndrome and Doctors 54 SDN Vol. 6, No. 1, p. 5-6 Q&A: Down’s Syndrome and Doctors? (continued) 56 SDN Vol. 6, No. 3, p. 9-10 Q&A: Down’s Syndrome Basic Questions? 58 SLN Vol. 6, No. 7, p. 8-11 Q&A: Prozac for Down’s Syndrome? 62 SLN Vol. 6, No. 8, p. 5-6 Q&A: Prozac vs Constipation? 64 SLN Vol. 6, No. 9, p. 3 Sidebar: Oxidative Stress in Children during Heart Surgery 65 SLN Vol. 6, No. 9, p. 5-7 Q&A: Antioxidant Supplements? 68 SLN Vol. 6, No. 9, p. 9 Q&A: GABA and Muscle Tone in DS? 69 SLN Vol. 7, No. 1, p. 7-8 Q&A: Dr. Warner on Piracetam? 71 SLN Vol. 7, No. 5, p. 10-11 Q&A: In Utero DS Therapy? 73 SLN Vol. 7, No. 6, p. 8-9 Q&A: Starting TNI Therapy? 74 p. 9-11 Q&A: Pyruvate for Down’s Syndrome? 77 SLN Vol. 7, No. 7, p. 9 Q&A: Allergy to Piracetam? 78 SLN Vol. 7, No. 7, p. 10-11 Q&A: Cell Therapy? 80 SLN Vol. 7, No. 8, p. 8-9 Q&A: No Piracetam for Down’s Syndrome? 82 SLN Vol. 7, No. 9, p. 6-8 Q&A: Antioxidants vs Reductants? 85 SLN Vol. 8, No. 1, p. 10 Q&A: Vinpocetine in Down’s Syndrome? Copyright © 1992-2002 by the Cognitive Enhancement Research Institute. All rights reserved. Phone 650-321-CERI (2374) Smart Drug NewNewss THE NEWSLETTER OF THE COGNITIVE ENHANCEMENT RESEARCH INSTITUTE Smart Drug News Smart Drug Update: Part 1 ISSN 1060-8427 Published 10 times annually by CERI (the Smart Drugs and Downs Syndrome Cognitive Enhancement Research Institute) by Steven Wm. Fowkes and Ward Dean, M.D. P. O. Box 4029 If you listen to scientists who specialize medications and refused to issue a New Drug Menlo Park, CA 94026. 415-321-CERI in academic research into Down’s syndrome, Application for them. Nevertheless, (415-321-2374) or to the Down’s Syndrome Association, U-series medications were determined to be Copyright © 1994 there is basically nothing a parent can do to legal for distribution within the state of All rights reserved. prevent the profound mental deficits and Michigan, where over 5,000 patients were Subscription $44/year impaired growth of a Down’s child. But if treated with some success. Canadian $46/year Overseas $55/year you listen to Dixie Lawrence, a devoted Single issue $6 adoptive mother of one Down’s child, or to Jack Warner, M.D. Vol. 2, No. 10 Dr. Jack Warner, a California pediatrician Dr. Turkel’s treatment has now been February 14, 1994 with a ten-year history of treating Down’s refined by California pediatrician Jack Editor children, there is plenty that parents can do. Warner, M.D. Dr. Warner and his wife Steven Wm. Fowkes In fact, this small group of motivated Charlene run The Warner House,acenterfor Medical Editors parents and dedicated practitioners has the study of trisomy disorders, in Fuller- ton, Ward Dean, M.D.