Program of the GEBIN
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16th Meeting of the GerminalCenterConference Frankfurt, July 5-9, 2009 Dear Participant, Welcome to the 16th International Conference on Lymphatic Tissues and Germinal Centres in Immune Reactions also affectionately known as the Germinal Centre Conference (GCC). This conference has a long- standing tradition of more than 30 years in which leading scientists meet to discuss recent developments of innate and adaptive immunity with special emphasis on in vivo biology. Topics such as mechanisms underlying lymphoid tissue formation, B and T cell immunity and stro- mal cell-leukocyte interactions are traditionally covered. The 16th GCC also marks a turning point in the organization, as it extends its tradition in two new directions. In one embodiment, math- ematical modelling is maturing to a point where this tool provides sig- nificant assistance for the design and interpretation of complex immuno- logical experiments. In addition, current modelling now allows testing a variety of hypotheses in silico to make predictions for the behaviour of biological systems that can be tested in real experiments. As such, modelling has become a powerful tool to speed up immunological dis- covery. Therefore, a major focus of the 16th GCC will be to compare descriptions and predictions of immune responses derived from in silico simulations with in vivo results. A second extension will be the presentation and discussion of systemic approaches to immunity. In a holistic perspective immune responses are set into a functional context that allows to study the interaction between subsystems of the organism. Within the 16th GCC, systemic approaches will be featured which investigate the interaction between innate and adaptive immunity, the emergence of autoimmune diseases and the interaction of the immune system with the neuronal and the endocrine system. The latter topic is further emphasized by organizing the GCC together with the German-Endocrine-Brain-Immune-Network (GEBIN). To maximize efficiency in this regard, the GEBIN meeting has been organized in the same facility where it will commence as an overlapping session on the last day of the GCC. Furthermore, the inter- 2 actions between both communities will be promoted by allowing par- ticipants of the GEBIN to visit sessions of the GCC and vice versa. In addition to the classic scientific sessions, the 16th GCC will begin with a satellite workshop the afternoon prior to the keynote address. The aim of the workshop is to explore the powerful methods of imaging immune cells under various conditions with a focus on exploiting in- travital two-photon microscopy. The workshop intends to have fruitful discussions not only on results but also about technological develop- ments as well as protocol choices and novel ways of data analysis and interpretation. This dialog will be generated by experienced researchers in this field and is intended to help attendees optimize experimental con- ditions that are required to achieve robust and relevant data or simply to motivate newcomers to incorporate imaging experiments for their questions. The investigation of immune function with regard to the topics cov- ered by the GCC and GEBIN is a major challenge for science and ultimately how it impacts on public health through development of to- morrows medicines. The organizers hope to stimulate future research by bringing such diverse scientific expertise together under one roof for a few days. On the campus of this historical site, we hope to create an atmosphere that encourages sharing of ideas in the short term as well as sow seeds for long term fruitful collaborations. The investigation of immune function with regard to the topics covered by the GCC and GEBIN is a major challenge for science and ultimately how it impacts on public health through development of tomorrows medicines. The organizers hope to have helped bias future research by bringing such diverse scientific expertise together under one roof for a few days. On the campus of this historical site, we hope to have created an atmosphere to encourage sharing of ideas in the short term as well as sow seeds for long term fruitful collaborations. 3 The 16th GCC could not have been organized and executed without the generous and concerted effort from numerous individuals. Partic- ular thanks and sincere gratitude is extended to the organizing com- mittee at Frankfurt Institute for Advanced Studies (FIAS): Alexander Achenbach, Walburga Bergmann, Jaaber Dehghani, Marc Thilo Figge, Graziela Grise, Gisbert Jockenhfer, Harald Kempf, Harsh Jain, Michael Lehmann, Eike Schdel, Gaby Schmitz. Also, very special thanks go to our financial sponsors for without this unique source of funding, the conference could not take place. These include: Deutsche Forschungsgemeinschaft • EU-NEST-project MAMOCELL within FP6 • (http://fias.uni-frankfurt.de/ immunology/RESEARCH/mamocell.html) Roche • Merck Serono • Nikon • Science Magazine • Frankfurt Institute for Advanced Studies (FIAS) • Also, it was a pleasure to work with Rainer Straub. He organised the GEBIN meeting and it was very stimulating to together with him set up a frame that links the two widely disconnected communities. Finally, we would also like to thank the various committees and other individ- uals who provided advice and technical support throughout the process. We hope that our aims will be realized and that you will significantly benefit from the interactions you experience both at the conference and during your stay in Frankfurt. Michael Meyer-Hermann Marie Kosco-Vilbois (GCC organizer) (GCC organizer) Matthias Gunzer (Satellite Workshop organizer) 4 Scientific advisory board Chair: Marie Kosco-Vilbois (Geneva, Switzerland) Claudia Berek (Berlin, Germany) Ernst Heinen (Li´ege,Belgium) Beat Imhof (Geneva, Switzerland) John Kearney (Birmingham, USA) Frans Kroese (Groningen, Netherlands) Ian Maclennan (Birmingham, UK) Organizing Committee Michael Meyer-Hermann (Frankfurt, Germany) Marie Kosco-Vilbois (Geneva, Switzerland) Matthias Gunzer (Satellite workshop, Magdeburg, Germany) Rainer H Straub (GEBIN conference, Regensburg, Germany) Local Organizing Committee Alexander Achenbach Walburga Bergmann Jaaber Dehghani Marc Thilo Figge Graziela Grise Gisbert Jockenh¨ofer Harald Kempf Harsh Jain Michael Lehmann Michael Meyer-Hermann Eike Sch¨adel Gaby Schmitz 5 Information Further information about the GCC 2009 meeting can be found on the GCC homepage: www.gcc16.org Sponsors Deutsche Forschungsgemeinschaft DFG FIAS EU-NEST-project MAMOCELL within FP6 Merck Serono Nikon Roche Science/AAAS 6 Title Germinal centre cell motility Mathematics of B cell motility Imaging immune cells in the marrowcoffee of break long bones Structures, signals and cellmune interactions responses involved as in revealed adaptive by im- dynamicTowards estimating the intravital true imaging duration ofwith dendritic T cell interactions cells Human lymphoid tissueopment inducer and cells immunity at the crossroadsIn of vivo devel- dynamicsnovel of experimental approach intraepithelialrescence based lymphocytes two-photon on microscopy in high-resolution the autofluo- gut: a 7 14:3515:10 1.115:40 1.216:1016:45 1.3 Michael Meyer-Hermann Matthias17:05 Gunzer 1.4 1.517:40 Ron Germain 1.6 Joost Beltman Yolanda Carrasco Andreas Gebert Time Subsession Page Speaker 14:00 1 Michael Nussenzweig Sunday July 5th, 2009 2pm - 6pm SatelliteChair: workshop: Matthias Two-photon Gunzer imaging: Techniques and potential 7pm: Welcome address by Michael Meyer-Hermann 7:10pm: Keynote address by Michel Nussenzweig: Building high affinity humoral responses 8 Title Onto- and neo-genesis of lymphoidHuman tissue lymphoid tissueopment inducer and cells immunity at the crossroadsImmunological of competence devel- ofprenatal spleen vascular isNkx2-3 commitment determined through involving its homeodomainThe factor nuclear export sequencefunction of in AID CSR determines its stabilitycoffee and break Follicular dendritic cells Predictive computer simulationsgerminal of centers impaired TLR4 functionA in role for Plexin B2 inAntibodies germinal in centre germinal survival centres, aMice role deficient for B for cellminal CD137 selection? center-derived ligand B are cell predisposed lymphoma to develop ger- Time Subsession Page Speaker 09:00 1 Reina Mebius 09:35 1.109:55 1.210:1510:35 Tom Cupedo 1.311:05 P´eterBalogh 11:40 212:00 2.1 Julia I. Ellyard 12:20 2.212:40 2.3 John G. Tew 2.4 Marc Thilo Figge Robert J Rigby Yang Zhang Jannie Borst Monday July 6th, 2009 9am - 1pmChair: GCC1: Reina Mechanisms Mebius, driving John lymphoid G tissue Tew development and germinal centre reaction activation at the immunological synapse guides T cell help ζ 9 Title PKC delivery Agent-based modeling of Tadaptive cell immune activation and proliferation in an The interpretation ofments data from stable isotopeReconstruction of labeling a experi- lymphoid T zonecoffee in break vitro T cell selection and tolerance GATA-3, c-Maf,cytokine control Helios in T mRNA cellsCD70-driven responding expression in co-stimulation vivo impairs relatedinstructing IgG T antibody to cells responsesFasL-Fas to interactions Th2- by eliminate germinal centerFollicular B dendritic cells cell-dependent but through sponses T to cell-independent Ab T-cell re- dependent antigens CD31 (PECAM-1) is requiredimmunity to for Salmonella naive CD4 T cell survival and Time Subsession Page Speaker 15:00 1 Salvatore Valitutti 15:3515:55 1.116:15 1.216:35 1.317:05 Gib Bogle 17:40 2 Rob de Boer 18:00 Stefanie Siegert 2.218:20 Arup K. Chakraborty 18:40