16th Meeting
of the
GerminalCenterConference
Frankfurt, July 5-9, 2009 Dear Participant,
Welcome to the 16th International Conference on Lymphatic Tissues and Germinal Centres in Immune Reactions also affectionately known as the Germinal Centre Conference (GCC). This conference has a long- standing tradition of more than 30 years in which leading scientists meet to discuss recent developments of innate and adaptive immunity with special emphasis on in vivo biology. Topics such as mechanisms underlying lymphoid tissue formation, B and T cell immunity and stro- mal cell-leukocyte interactions are traditionally covered.
The 16th GCC also marks a turning point in the organization, as it extends its tradition in two new directions. In one embodiment, math- ematical modelling is maturing to a point where this tool provides sig- nificant assistance for the design and interpretation of complex immuno- logical experiments. In addition, current modelling now allows testing a variety of hypotheses in silico to make predictions for the behaviour of biological systems that can be tested in real experiments. As such, modelling has become a powerful tool to speed up immunological dis- covery. Therefore, a major focus of the 16th GCC will be to compare descriptions and predictions of immune responses derived from in silico simulations with in vivo results.
A second extension will be the presentation and discussion of systemic approaches to immunity. In a holistic perspective immune responses are set into a functional context that allows to study the interaction between subsystems of the organism. Within the 16th GCC, systemic approaches will be featured which investigate the interaction between innate and adaptive immunity, the emergence of autoimmune diseases and the interaction of the immune system with the neuronal and the endocrine system. The latter topic is further emphasized by organizing the GCC together with the German-Endocrine-Brain-Immune-Network (GEBIN). To maximize efficiency in this regard, the GEBIN meeting has been organized in the same facility where it will commence as an overlapping session on the last day of the GCC. Furthermore, the inter-
2 actions between both communities will be promoted by allowing par- ticipants of the GEBIN to visit sessions of the GCC and vice versa.
In addition to the classic scientific sessions, the 16th GCC will begin with a satellite workshop the afternoon prior to the keynote address. The aim of the workshop is to explore the powerful methods of imaging immune cells under various conditions with a focus on exploiting in- travital two-photon microscopy. The workshop intends to have fruitful discussions not only on results but also about technological develop- ments as well as protocol choices and novel ways of data analysis and interpretation. This dialog will be generated by experienced researchers in this field and is intended to help attendees optimize experimental con- ditions that are required to achieve robust and relevant data or simply to motivate newcomers to incorporate imaging experiments for their questions.
The investigation of immune function with regard to the topics cov- ered by the GCC and GEBIN is a major challenge for science and ultimately how it impacts on public health through development of to- morrows medicines. The organizers hope to stimulate future research by bringing such diverse scientific expertise together under one roof for a few days. On the campus of this historical site, we hope to create an atmosphere that encourages sharing of ideas in the short term as well as sow seeds for long term fruitful collaborations.
The investigation of immune function with regard to the topics covered by the GCC and GEBIN is a major challenge for science and ultimately how it impacts on public health through development of tomorrows medicines. The organizers hope to have helped bias future research by bringing such diverse scientific expertise together under one roof for a few days. On the campus of this historical site, we hope to have created an atmosphere to encourage sharing of ideas in the short term as well as sow seeds for long term fruitful collaborations.
3 The 16th GCC could not have been organized and executed without the generous and concerted effort from numerous individuals. Partic- ular thanks and sincere gratitude is extended to the organizing com- mittee at Frankfurt Institute for Advanced Studies (FIAS): Alexander Achenbach, Walburga Bergmann, Jaaber Dehghani, Marc Thilo Figge, Graziela Grise, Gisbert Jockenhfer, Harald Kempf, Harsh Jain, Michael Lehmann, Eike Schdel, Gaby Schmitz. Also, very special thanks go to our financial sponsors for without this unique source of funding, the conference could not take place. These include:
Deutsche Forschungsgemeinschaft • EU-NEST-project MAMOCELL within FP6 • (http://fias.uni-frankfurt.de/ immunology/RESEARCH/mamocell.html) Roche • Merck Serono • Nikon • Science Magazine • Frankfurt Institute for Advanced Studies (FIAS) • Also, it was a pleasure to work with Rainer Straub. He organised the GEBIN meeting and it was very stimulating to together with him set up a frame that links the two widely disconnected communities. Finally, we would also like to thank the various committees and other individ- uals who provided advice and technical support throughout the process.
We hope that our aims will be realized and that you will significantly benefit from the interactions you experience both at the conference and during your stay in Frankfurt.
Michael Meyer-Hermann Marie Kosco-Vilbois (GCC organizer) (GCC organizer)
Matthias Gunzer (Satellite Workshop organizer)
4 Scientific advisory board
Chair: Marie Kosco-Vilbois (Geneva, Switzerland) Claudia Berek (Berlin, Germany) Ernst Heinen (Li´ege,Belgium) Beat Imhof (Geneva, Switzerland) John Kearney (Birmingham, USA) Frans Kroese (Groningen, Netherlands) Ian Maclennan (Birmingham, UK)
Organizing Committee
Michael Meyer-Hermann (Frankfurt, Germany) Marie Kosco-Vilbois (Geneva, Switzerland) Matthias Gunzer (Satellite workshop, Magdeburg, Germany) Rainer H Straub (GEBIN conference, Regensburg, Germany)
Local Organizing Committee
Alexander Achenbach Walburga Bergmann Jaaber Dehghani Marc Thilo Figge Graziela Grise Gisbert Jockenh¨ofer Harald Kempf Harsh Jain Michael Lehmann Michael Meyer-Hermann Eike Sch¨adel Gaby Schmitz
5 Information
Further information about the GCC 2009 meeting can be found on the GCC homepage: www.gcc16.org
Sponsors
Deutsche Forschungsgemeinschaft DFG FIAS EU-NEST-project MAMOCELL within FP6 Merck Serono Nikon Roche Science/AAAS
6 Sunday July 5th, 2009
2pm - 6pm Satellite workshop: Two-photon imaging: Techniques and potential Chair: Matthias Gunzer
7pm: Welcome address by Michael Meyer-Hermann
7:10pm: Keynote address by Michel Nussenzweig: Building high affinity humoral responses
Time Subsession Page Speaker Title 14:00 1 Michael Nussenzweig Germinal centre cell motility 14:35 1.1 Michael Meyer-Hermann Mathematics of B cell motility 15:10 1.2 Matthias Gunzer Imaging immune cells in the marrow of long bones 15:40 coffee break
16:10 1.3 Ron Germain Structures, signals and cell interactions involved in adaptive im- mune responses as revealed by dynamic intravital imaging
16:45 1.4 Joost Beltman Towards estimating the true duration of dendritic cell interactions with T cells
17:05 1.5 Yolanda Carrasco Human lymphoid tissue inducer cells at the crossroads of devel- opment and immunity In vivo dynamics of intraepithelial lymphocytes in the gut: a 17:40 1.6 Andreas Gebert novel experimental approach based on high-resolution autofluo- rescence two-photon microscopy
7 Monday July 6th, 2009
9am - 1pm GCC1: Mechanisms driving lymphoid tissue development and germinal centre reaction Chair: Reina Mebius, John G Tew
Time Subsession Page Speaker Title 09:00 1 Reina Mebius Onto- and neo-genesis of lymphoid tissue
09:35 1.1 Tom Cupedo Human lymphoid tissue inducer cells at the crossroads of devel- opment and immunity Immunological competence of spleen is determined through its 09:55 1.2 P´eterBalogh prenatal vascular commitment involving homeodomain factor Nkx2-3
10:15 1.3 Julia I. Ellyard The nuclear export sequence of AID determines its stability and function in CSR 10:35 coffee break 11:05 2 John G. Tew Follicular dendritic cells
11:40 2.1 Marc Thilo Figge Predictive computer simulations of impaired TLR4 function in germinal centers 12:00 2.2 Robert J Rigby A role for Plexin B2 in germinal centre survival 12:20 2.3 Yang Zhang Antibodies in germinal centres, a role for B cell selection?
12:40 2.4 Jannie Borst Mice deficient for CD137 ligand are predisposed to develop ger- minal center-derived B cell lymphoma
8 Monday July 6th, 2009
3pm - 7pm GCC2: T cells in lymphoid tissue Chair: Arup K Chakraborty, Salvatore Valitutti
Time Subsession Page Speaker Title
15:00 1 Salvatore Valitutti PKCζ activation at the immunological synapse guides T cell help delivery
15:35 1.1 Gib Bogle Agent-based modeling of T cell activation and proliferation in an adaptive immune
15:55 1.2 Rob de Boer The interpretation of data from stable isotope labeling experi- ments 16:15 1.3 Stefanie Siegert Reconstruction of a lymphoid T zone in vitro 16:35 coffee break 17:05 2 Arup K. Chakraborty T cell selection and tolerance
17:40 Karine Serre GATA-3, c-Maf, Helios mRNA expression related to Th2- cytokine control in T cells responding in vivo CD70-driven co-stimulation impairs IgG antibody responses by 18:00 2.2 Klaas van Gisbergen instructing T cells to eliminate germinal center B cells through FasL-Fas interactions
18:20 2.3 Mohey El Shikh Follicular dendritic cell-dependent but T cell-independent Ab re- sponses to T-cell dependent antigens
18:40 2.4 Ruth Coughlan CD31 (PECAM-1) is required for naive CD4 T cell survival and immunity to Salmonella
9 Tuesday July 7th, 2009
9am - 1pm GCC3: Adaptive innate immunity and vice versa Chair: Yang-Xin Fu, Serge Lebecque
Time Subsession Page Speaker Title 09:00 1 Yang-Xin Fu T cells suppress innate immune response
09:35 1.1 Adam F Cunningham The porin OmpD from non-typhoidal Salmonella is a key target for a protective B1b antibody response 09:55 1.2 Tibor Veres Dynamic imaging of airway mucosal dendritic cell activity ex vivo
10:15 1.3 G¨unter Steiner Characterization of an arthritogenic autoantigen in rats with pristane-induced arthritis 10:35 coffee break 11:05 2 Serge Lebecque Toll-like-receptors and apoptosis
11:40 2.1 Elodie Mohr CD8 T cells induce T-bet in B cells that switch to IgG2a and express CXCR3 during a Th2-response
12:00 2.2 Robert K. Gieseler Significant Reduction of T-Cell Infectivity by CTL-targeted Con- A Delivery to HIV? Reservoir APCs
12:20 2.3 Yang Liu A novel pathway to discriminate danger- vs pathogen-associated molecular patterns
3pm: Social Programme at Justitiabrunnen auf dem R¨omerberg (see page 32 for details)
7pm: Conference Party in the Casino
10 Wednesday July 8th, 2009
9am - 1pm GCC4: B cell diversity in health and disease Chair: Alan S Perelson, Andreas Radbruch
Time Subsession Page Speaker Title
09:00 1 Alan S. Perelson Modeling B cells: From Repertoires to B Cell Proliferation and Differentiation
09:35 1.1 Thomas Grundstr¨om Initiation of Antigen Dependent Differentiation into Plasma Cells by Calmodulin Inhibition of E2A
09:55 1.2 Stefano Casola Polycomb group protein Ezh2 regulates germinal center responses and terminal B cell differentiation 10:15 1.3 Weisel Florian Reactivation requirements for virus-specific memory B cells 10:35 coffee break 11:05 2 Andreas Radbruch T helper cell memory Molecular footprints for a germinal center derivation of human so- 11:40 2.1 Marc Seifert matically mutated IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation
12:00 2.2 Uri Hershberg The focused analysis of Ig mutation patterns correctly detects B cell selection in health and disease
12:20 2.3 Mats Bemark Adjuvant dose regulates germinal center size and quality of the humoral response
12:40 2.4 Bruce Mazer Semaphorin 4C: A unique B-cell molecule expressed following Th2 stimulation mediates migration to airway epithelium.
11 Wednesday July 8th, 2009
3pm - 7pm GCC5: Tertiary lymphoid tissue and ectopic germinal centres in autoimmunity Chair: Francesca Aloisi, Claudia Berek
Time Subsession Page Speaker Title Ectopic B-cell follicles as a reservoir of EBV infected B cells in 15:00 1 Francesca Aloisi the multiple sclerosis brain The frequency of autoreactive germinal center B cells and plasma 15:35 1.1 Hedda, Wardemann cells in normal and autoimmune mice The human artificial lymph node: modelling immune functions 15:55 1.2 Christoph Giese in vitro using a micro-organoid culture Strong induction of colonic Isolated lymphoid follicles by activa- 16:15 1.3 Emma Mader tion of the alternative NF-kappa B pathway 16:35 coffee break 17:05 2 Claudia Berek Ectopic germinal centres in rheumatoid arthritis Putative precursors of follicular dendritic cells in the absence of 17:40 2.1 Nike Krautler B lymphocytes or lymphotoxin beta receptor signaling
18:00 2.2 Michelle A. Linter- T follicular helper cells are required for spontaneous germinal man center formation and autoimmunity in sanroque mice. Experimental arthritis causes tumor necrosis factor-a dependent Gisela Segond von 18:20 2.3 infiltration of macrophages in rat dorsal root ganglia which cor- Banchet relates with pain-related behavior 18:40 Poster award by Science Magazine
12 Thursday July 9th, 2009
9am - 1pm GCC6: Neuro-Endocrine-Immune-Interactions Chair: Cobi J Heijnen, Rainer H Straub
Time Subsession Page Speaker Title 09:00 1 Rainer H Straub Neuro-endocrine-immune-system
09:35 1.1 Thomas Bollinger Analysis of the molecular clock in CD4+ T cells and its relevance for the functional circadian rhythm of CD4+ T cells
09:55 1.2 Ernst Heinen Germinal centre innervation of bovine and human tonsils related to prion diseases 10:15 1.3 Ayse Kilic Nerve Growth Factor: a candidate for airway remodelling? 10:35 coffee break 11:05 2 Cobi J Heijnen G-protein coupled receptors
11:40 2.1 J¨urgenKraus Cannabinoid and Opioid-mediated increase in cyclic AMP in- hibits T cell receptor-triggered signaling
12:00 2.2 Christiane Liezmann A new role for the spleen as a conductor of neuro-immune regu- lation in allergic dermatitis ? Suppression of IL-6 production from cholinergic stimulated 12:20 2.3 Olga Malysheva PBMS is connected to high expression of non α-Bungarotoxin nicotine type of acetylcholine receptor on CD14+ cells
12:40 2.4 Carsten Riether beta-adrenoceptor stimulation inhibits calcineurin in CD4+ T lymphocytes via a PKA- dependent pathway
13 7th Meeting
of the
German-Endocrine-Brain-Immune-Network
Frankfurt, July 8-11, 2009 Dear Colleagues,
The 7th GEBIN Symposium will be held in Frankfurt a.M. between July 8th-11th, 2009. This year it will be a joint meeting with the Ger- minal Center Conference (GCC). The GCC meeting will be between July 5-9, 2009.
According to the overall aim of the GEBIN, this meeting will provide an exciting and interdisciplinary program covering various fields including anatomy, dermatology, endocrinology, ethology, immunology, neurol- ogy, pharmacology, psychiatry, psychology, and zoology. The GEBIN meeting is supported by the two International societies of International Society of Neuroimmunomodulation and PsychoNeuroImmunology Re- search Society.
The Symposium will be divided into several thematic sessions. Each session consisting of short oral presentations will be opened with an introductory lecture of an internationally recognized expert in the re- spective field. All contributions will be published in an issue of Brain Behavior and Immunity.
The organizers of the GEBIN Symposium 2009 are proud to offer again an Educational Short Course for students. This course will be held prior to the official start of the GEBIN meeting, and is intended to present aspects of Behavior-Neuro-Endocrine-Immune interactions on a scholarly level.
We would highly appreciate your participation in this exciting meeting and look forward to welcoming you in Frankfurt in July 2009.
With kind regards
Rainer H. Straub, GEBIN
15 Local Organizing Committee
Rainer H. Straub and team, for GEBIN Silvia Capellino Alexander Faßold Stefanie Haas Torsten Lowin Georg Pongratz Christine Wolff
Scientific Committee
Prof. Dr. P.C. Arck, Berlin Prof. Dr. H.O. Besedovsky, Marburg Prof. Dr. M. B¨ohm,M¨unster Prof. Dr. J. Born, L¨ubeck Prof. Dr. A. del Rey, Marburg Dr. H. Engler, Essen Dr. B. Fiebich, Freiburg Prof. Dr. R. Gold, Bochum Prof. Dr. V. H¨ollt,Magdeburg PD Dr. J. Kraus, Magdeburg Dr. T. Lange, L¨ubeck Prof. Dr. N. M¨uller,M¨unchen Prof. Dr. M. Schedlowski, Essen PD Dr. M. Schwarz, M¨unchen Prof. Dr. G.K. Stalla, M¨unchen PD Dr. V. Stefanski, Berlin Prof. Dr. R.H. Straub, Regensburg Prof. Dr. E. Weihe, Marburg
Abstract quality estimation was performed by all members of the sci- entific committee using a metric system similar to a visual analog scale. The mean value of the estimation score was calculated to find the best 5 abstracts, which will be presented on Thursday afternoon (16:30).
16 Information
Further information about the GEBIN and the GEBIN 2009 meeting can be found on the GEBIN homepage: www.gebin.org
Coffee Breaks and Lunch
Coffee, lunch and refreshments will be available in the foyer (ground level) and in the Mensa of the Campus Westend.
Main Sponsors / Exhibitors
Biozol Frankfurt Institute for Advanced Studies (FIAS) EU-NEST-project MAMOCELL within FP6 (http://fias.uni-frankfurt.de/ immunology/RESEARCH/mamocell.html) Merck Serono Millipore Roche
Supported by
Deutsche Forschungsgemeinschaft
Deutsche Anatomische Gesellschaft Deutsche Dermatologische Gesellschaft Deutsche Ethologische Gesellschaft Deutsche Gesellschaft f¨urBiologische Psychiatrie Deutsche Gesellschaft f¨urEndokrinologie Deutsche Gesellschaft f¨urImmunologie Deutsche Gesellschaft f¨urMedizinische Psychologie Deutsche Gesellschaft f¨urNeurologie Deutsche Gesellschaft f¨urPharmakologie Deutsche Gesellschaft f¨urPsychologie Deutsche Gesellschaft f¨urZoologie
17 PsychoNeuroImmunology Research Society (PNIRS) International Society of Neuroimmunomodulation (ISNIM) The European Neuropeptide Club World Psychiatric Association, Section Immunology and Psychiatry
Acknowledgements
The organizers are grateful for expert assistance to:
Angelika Gr¨aber Madlen Melzer Margit N¨utzel Luise Rauch Olga Wiesner all from the University Hospital Regensburg, Dept. of Internal Medicine
18 Wednesday July 8th, 2009
9am - 6:30pm Educational Short Course Organizer: Adriana del Rey
Location: Eisenhower Conference Room, IG Farben Building, Campus Westend of the JW Goethe-University
Time Title Speaker Affiliation 09:00-09:15 Introduction Abt. f¨ur Immunologie und Medi- Infectious diseases in today’s 09:15-10:00 Thomas Jacobs zinische Mikrobiologie, Bernhard-Nocht- world Institut f¨urTropenmedizin, Hamburg Inst. of Physiology and Pathophysioloy, 10:00-10:45 INEI and infectious diseases Adriana del Rey Philipps University, Marburg 10:45-11:15 coffee break
11:15-12:00 Development of autoim- Alexander Dalpke Dept. of Hygiene and Medical Microbiol- mune diseases ogy, University of Heidelberg Division of Rheumatology, JW Goethe- 12:00-12:45 INEI and autoimmunity Matthias Wahle University Hospital, Frankfurt am Main 12:45-13:30 lunch break
19 Wednesday July 8th, 2009
9am - 6:30pm Educational Short Course Organizer: Adriana del Rey
8pm Trainee Dinner (only for participating students)
Time Title Speaker Affiliation
13:30-14:15 The basis of central neurologi- Prof. Dr. Richard Dodel Neurologische Klinik, Univer- cal disease sit¨atsklinikumGiessen und Marburg Neuroimmunologisches Labor, Neurol- 14:15-15:00 INEI and neuroimmunology Dr. Ralf Linker ogische Klinik der Ruhr-Universitaet, Bochum 15:00-15:30 coffee break
15:30-16:15 The most common psychiatric Prof. Dr. Thomas Pollm¨acher Klinikum Ingolstadt, Zentrums f¨urpsy- diseases chische Gesundheit, Ingolstadt Laborsektion PsychoNeuroImmunologie, 16:15-17:00 INEI and psychiatric diseases PD Dr. Markus Schwarz Klinik Psychiatrie und Psychotherapie, M¨unchen 17:00-17:30 coffee break 17:30-18:30 Discussion with the Students
20 Thursday July 9th, 2009
9am - 1pm Peripheral Neuroimmune Interactions, Part 1 (Organized jointly with the GCC) Chairs: Cobi J. Heijnen, Rainer H. Straub
Time Page Speaker Title 09:00 Rainer H. Straub Role of the nervous system in arthritis
09:35 Thomas Bollinger Analysis of the molecular clock in CD4+ T cells and its relevance for the functional circadian rhythm of CD4+ T cells 09:55 Ernst Heinen Germinal centre innervation of bovine and human tonsils related to prion diseases 10:15 Ayse Kilic Nerve Growth Factor: a candidate for airway remodeling? 10:35 break 11:05 Cobi J. Heijnen Regulatory mechanisms of chronic inflammatory pain
11:40 J¨urgenKraus Cannabinoid and opioid-mediated increase in cyclic AMP inhibits T cell receptor- triggered signaling
12:00 Christiane Liezmann A new role for the spleen as a conductor of neuro-immune regulation in allergic dermatitis? Suppression of IL-6 production from cholinergic stimulated PBMS is connected to 12:20 Olga Malysheva high expression of non α-Bungarotoxin nicotine type of acetylcholine receptor on CD14+ cells
12:40 Carsten Riether Beta-adrenoceptor stimulation inhibits calcineurin in CD4+ T lymphocytes via a PKA- dependent pathway 13:00 lunch
21 Thursday July 9th, 2009
2pm - 4:05pm Neuroimmunology Related to the CNS Chairs: Ralf Gold, Bernd Fiebig, Ralf A. Linker
Time Page Speaker Title 14:00 Ralf A. Linker Neuroimmunology and Neuroprotection
14:35 Isabella Peruga Altered affective behavior in a model of multiple sclerosis: impact of neurotrophic factors Significant elevation of serum levels of macrophage-migration-inhibitory-factor 14:50 Larissa de la Fontaine (MIF) and CD14 - Sign for over-stimulation of the monocytes/macrophages-system (MMS) in schizophrenia The mood stabilizer valproic acid down regulates neuronal cyclooxygenase-2 ex- 15:05 Vikramjeet Singh pression: cenral role of nuclear factor-kappa B after long term, but not short- term treatment 15:20 Knut Biber Secondary lymphoid tissue chemokine (CCL21) in neuron-microglia signaling
15:35 Horst-G Maxeiner T-cell alterations in CSF and peripheral blood in patients with neuropsychiatric disorders 15:50 Barbara Fellerhoff Association between Chlamydophila infections and schizophrenia 16:05 break
22 Thursday July 9th, 2009
4:30pm - 6:10pm Top Contributions Session (best abstracts) Chairs: Markus B¨ohm,Hugo O. Besedosvky
Time Page Speaker Title
16:30 Georg Pongratz The SNS promotes the development of B cells that show regulatory potential in arthritis
16:50 Silvia Capellino Local catecholamine production and synovial inflammation: new target for arthritis therapy? 17:10 Harald Engler Destruction of brainstem noradrenergic neurons affects splenic cytokine production
17:30 Sven Benson Subclinical depressive symptoms are associated with galectin-1 and interleukin-6 levels
17:50 Jutta M. Wolf PTSD: Changes in signal transduction pathways central to the endocrine-immune interplay 18:15 break
23 Thursday July 9th, 2009
6:30pm - 8:15pm Peripheral Neuroimmmune Interaction, Part 2 Chairs: Harald Engler, Georg Pongratz
Time Page Speaker Title
18:30 Timo Wirth Regulatory T cells and the sympathetic nervous system in a murine model of au- toimmune disease 18:45 Alexander Faßold Interception of repulsion factors: a possible treatment of rheumatoid arthritis? 19:00 Agatha Kokot Tropisetron - a novel antifibrotic agent 19:15 Markus B¨ohm Melanocortin peptides and derivatives - emerging antifibrotic therapeutic tools 19:30 Ngoc Quan Phan Uremic pruritus: Characterization of clinical and immunohistological parameter
19:45 Torsten Lowin Cortisol, steroid hormones and cannabinoids influence integrin alpha5 expression and adhesion to fibronectin in synovial fibroblasts
20:00 Tanja Lange Cortisol and epinephrine differentially influence CXCR4+ and CX3CR1+ lympho- cytes
24 Friday July 10th, 2009
9am - 11:45am Neuroendocrine Network in Psychiatric Disease Chairs: Norbert M¨uller, Markus J. Schwarz, Bernd Fiebig
Time Page Speaker Title
09:00 Hemmo Drexhage An activated inflammatory response system as co-factor for the develop- ment of major psychiatric diseases 09:35 Markus J. Schwarz Tryptophan metabolism and immunogenetics in major depression
09:50 B. D. Karrenbauer Interleukin-2 reduces extracellular cortical serotonin and increases depression- related behaviour in the forced swim test in rats 10:05 Daniela Friebel The impact of COX-2 inhibitors for the treatment of early stage schizophrenia 10:20 break 11:00 Norbert M¨uller Antiinflammatory therapy in psychiatric disorders 11:15 Richard Musil Changes in prolactin levels as predictor of response to treatment with aripiprazole
11:30 Daniela Friebel The association between the immune system, neurotransmitter balance, infections and schizophrenia 11:45 lunch
25 Friday July 10th, 2009
1:30pm - 4pm Neuroendocrinology and Immune Function Chairs: Adriana del Rey, Rainer H. Straub, Tanja Lange
Time Page Speaker Title 13:30 Eduardo Arzt Molecular transduction mechanisms in cytokine-hormone interactions
14:05 Michael Meyer- Mathematical modeling of the circadian rhythm of key neuroendocrine Hermann immune players in rheumatoid arthritis - A systems biology approach Psychological and physiological consequences of chronic partial sleep loss in young 14:40 Christiane Berndt parents preliminary data and future intentions
14:55 Christian Bene- Enhancing influence of intranasal interleukin-6 on slow wave activity and memory dict consolidation during sleep 15:10 Stefanie Haas Circadian rhythms of synoviocytes in rheumatoid arthritis (RA) TLR4 and NOD innate immune receptors modulate the response of tumor pituitary 15:25 Bianca Fr¨ohlich AtT-20 cells through the PI3K/Akt survival pathway Estrone/17β-estradiol conversion and TNF inhibition by estrogen metabolites in 15:40 Martin Schmidt synovial cells of patients with RA and OA 16:00 break
26 Friday July 10th, 2009
4:30pm - 5:45pm Stress, Behaviour and Immune Function, Part 1 Chair: Manfred Schedlowski
Time Page Speaker Title 16:30 Jan-S. Grigoleit Effects of an acute experimental immune activation on mood and memory functions 16:45 Ulrike Gimsa Increased response to psychological stress in TNF-receptor deficient mice
17:00 Kerstin Schunke Agonistic behaviour and susceptibility to collagen-induced arthritis (CIA) in male Wistar rats 17:15 Annette Sommershof Chronic social stress influences virus specific T-cell response to LCMV infection
17:30 Chadi Touma Altered balance of pro- and anti-inflammatory cytokines in mice selected for in- creased stress reactivity
6pm - 7pm Meeting of the Steering Committee of the GEBIN Location: Seminarraum 1.802
27 Saturday July 11th, 2009
9am - 12noon Stress, Behaviour and Immune Function, Part 2 Chairs: Volker Stefanski, Sigrid Elsenbruch, Harald Engler, Manfred Schedlowksi
Time Page Speaker Title
09:00 Urs Meyer In-vivo rodent models for the experimental investigation of prenatal im- mune activation effects in neurodevelopmental brain disorders 09:35 Siobhan Lynch Effects of mindfulness-based coping with university life (MBCUL): a pilot study
09:50 Peggy Schneider Interleukin-2 affects social interaction behavior in relation to anxiety-like trait be- havior in the elevated plus-maze in adult Wistar rats
10:05 Nicolas Rohleder Acute psychosocial stress induces short-term catecholamine resistance of TNF, but not of IL-6 production in healthy young men
10:20 Sven Benson Subjective well-being is associated with marathon-induced pro-inflammatory state in older runners 10:35 break
11:00 Jutta M. Wolf Effects of parent versus child asthma self-efficacy on changes in inflammatory profiles over time 11:15 Stefan Reber Mechanisms behind psychosocial stress-induced spontaneous colitis in male mice
11:30 Kerstin Schunke Psychosocial confrontation stress reduces the susceptibility to collagen type II induced arthritis in rats
11:45 Clemens Steinert Stress challenge during late murine gestation: A programming agent for the origin of disease
28 Conference Venue
The GCC and GEBIN meetings of 2009 are being held in the Casino of the historical IG Farben Building, located at the following address. A brief history of this building follows.
IG Farben Building Campus Westend of the Johann Wolfgang Goethe-University Gr¨uneburgplatz1 60323 Frankfurt
In 1925, six major German chemical companies including BASF, Bayer and Hoechst, merged to form a consortium called IG Farben. They chose the city of Frankfurt to house their corporate headquarters be- cause of its central location, and accessibility by land and air. The famous architect Hans Poelzig was commissioned to design the build- ing, a task which he completed in only 24 months, in 1930. With nine floors and six wings, the IG Farben building was one of the largest and most modern buildings in Europe. It remained in the hands of IG Far- ben until the end of the Second World War.
From 1945 onwards, the IG Farben building was used as the headquar- ters of the American Forces in Europe, under the command of General Dwight D. Eisenhower. From 1949-1952, the United States High Com- missioner for Germany and his staff occupied the building. It became the principal location for implementing the Marshall Plan, which largely financed the post-war reconstruction of Europe. The state apparatus of the Federal German Government was also devised there.
In 1996, the state of Hesse bought the building and associated land for the University of Frankfurt. In 2001, parts of the Social Sciences were relocated to the IG Farben-Haus. Today, the building forms the core of a new Campus Westend which includes the departments of Philosophy, History, Theology, Modern Languages and Linguistics, and Cultural and Civilization Studies
More information about the rich history of the building can be found on Wikipedia, at http://en.wikipedia.org/wiki/IG Farben Building.
29 Visitor Information
Getting there
The IG Farben Building is easily accessible by public transport. The nearest U-Bahn station is Holzhausenstrasse, serviced by lines U1/2/3. From here, the venue is a 10 minute walk. The nearest bus stop is Uni Campus Westend, serviced by lines 36 and 75, and is only a 4 minute walk away. You may plan your journey online at www.rmv.de.
Coffee Breaks and Lunch
Coffee, lunch and refreshments will be available in the foyer and in the Mensa of the campus Westend located at the ground level of the Casino. Visitors can also enjoy several restaurants located within walk- ing distance of the building. A few of these are listed below and shown on a map overleaf. Alternatively, visitors may travel to the city-center (metro-station Hauptwache, U1/2/3/6/7) for a wide choice in eateries.
A. Sushi King B. Gargantua C. Omonia Gr¨uneburgweg 81 Liebigstr. 47 Vogtstr. 43 069 71448955 069 720718 069 593314
D. Knoblauch E. Vini... da Sabatini F. Pizzeria Romanella Staufenstr. 39 Gr¨uneburgweg 81 Wolfgangstr. 84 069 722828 069 726665 069 5961117
G. Le Cafe H. Ernos Bistro I. Pizzeria Armonia Gr¨uneburgweg 88 Liebigstr. 15 Eschersheimer Landstr. 38 069 5971509 069 721997 069 558924
J. La Boveda K. Novita L. Casa Pintor Feldbergstr. 10 Feldbergstr. 30 Bornwiesenweg 75 069 723220 069 97205548 069 5973723
M. Isoletta Feldbergstr. 31 069 174770
30 31 Social Program
A social program has been organized for GCC16 participants on Tues- day, 7th July. We offer sightseeing tours by foot through Frankfurt with 4 different themes:
1. Cultural Frankfurt (referee: Barbara Rubert) You will find a unique museum experience in downtown Frankfurt. The theatre landscape in Frankfurt entices you with its great variety.
2. Old Town (referee: Irina Andrej) See one of the most important market places in the history of Germany. Rebuilt after the last war, Frankfurt has many historical sights and tra- ditions.
3. Goethe and his Frankfurt (referee: Alexander Ruhe) The most well-known German poet is a son of Frankfurt. Follow the trail of a man who knew how to enjoy life and transfer the experience to poetry.
4. Frankfurt and its history (referee: Alexander Berger) No other German city has as many high rise buildings as Frankfurt. Learn about the details of the architecture and the occupants and come with us the top of the Maintower and enjoy the fascinating view of the town.
The common meeting point for all tours will be at Justitiabrunnen auf dem R¨omerberg (fountain) at 3pm. The tours will take about 2 hours and will be conducted in English. The tours will take place in all weather conditions, please come prepared!!
Getting there by Public Transport
From the IG Farben Building, walk to the Holzhausenstrasse metro- station. Take the U1/2/3 in the direction Frankfurt S¨udto the station Willy-Brandt-Platz. Change here either to U4 in the direction Pre- ungesheim or to U5 in the direction Enkheim. Travel to the metro station Dom/R¨omer. Reaching the surface, one is located on the marketplace R¨omer,and has to walk to the Justitiabrunnen (fountain). A map has been provided in the welcome pack for your convenience.
32 Conference Abstracts
The abstracts accepted for presentation in either poster or talk form for both conferences are printed here. These are arranged chronologically by session, so that GCC Satellite session is followed by GGC1 through GCC6, and finally by GEBIN. Within each session, the abstracts are arranged in alphabetic order, by presenting authors last name. To fa- cilitate search, an index of all authors is also included at the end of the abstract booklet.
Awards and publications
The best poster in the GCC will be awarded with an annual subscrip- tion to Science, the world’s leading scientific journal. The winner will receive 52 issues of Science over a year and access to news and research archives dating back to 1880.
We support the submission of full-length papers with theoretical and mathematical contributions in Immunology. Selected contributions that link Immunology to the science of Complex Systems will be published in the journal Advances in Complex Systems, as a topical part of a reg- ular issue.
The 5 best abstracts submitted to the GEBIN meeting will be presented on Thursday afternoon (4:30pm). Abstract quality estimation was per- formed by all members of the scientific committee using a metric system similar to a visual analog scale. The mean value of the estimation score was calculated to find these.
Poster Hanging
The position on the board where the posters must be hung is iden- tified by the page number in this booklet where the abstract appears. Posters from the GCC Satellite session, together with subsessions GCC1 through GCC3 must be displayed from Sunday, 5th July to Tuesday, 7th July, until 1pm. Posters belonging to the subsessions GCC4 through GCC6 must be displayed from 1pm on Tuesday, July 7th to the end of the conference, on Thursday, July 9th at 1pm.
33