Number of Companies Investing in Neuroscience Drug Discovery
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10/26/2015 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Neurological Disorders and Stroke NINDS Office of Translational Research: New Programs to Rajesh Ranganathan, PhD Support Therapy and Director, Office of Translational Research Device Discovery and NINDS Development [email protected] July 2015 Number of companies investing in Neuroscience drug discovery 2 1 10/26/2015 Number of companies investing in Neuroscience drug discovery 3 CNS drug discovery portfolio 4 2 10/26/2015 5 6 3 10/26/2015 Ecosystem is pursuing new models – eliminate silos Academia Biotech Pharma Project 1 Project 2 Project 3 Carsten Skarke and Garret A. FitzGerald, Science Translational Medicine April 2010 7 What should NINDS’s role be in this changing climate? 8 4 10/26/2015 Appropriations (Dollars in Thousands) FY 2011 FY 2012 FY 2013 FY2014 FY 2015 NINDS $1,622,003 $1,624,830 $1,533,795 $1,588,904 $1,604,607 NINDS % Base 0.2% -5.6% 3.6% 1.0% Change NIH $30,687,290 $30,860,387 $29,151,462 $30,150,853 $30,311,349 NIH % Change Base 0.6% -5.5% 3.4% 0.5% Average IC increase was 0.31% NINDS and NIMH each received increase of $12.3 M for BRAIN Initiative Funding up to 14 th percentile 9 Total NINDS Extramural Grants Budget 1.6 NINDS Extramural 1.4 1.2 adjusted to 1995 1 dollars 0.8 with ARRA Billions) 0.6 0.4 with ARRA-- 0.2 adjusted to 1995 NINDS Extramural Grant Dollars (in (in Dollars Grant Extramural NINDS dollars 0 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 10 5 10/26/2015 FY 2013 Taxpayer Investment in Neuroscience Now Exceeds Cancer 7 6 5.274 5.34 4.887 5 4 3 Dollars in Billions (FY 2013) BillionsinDollars(FY 2 1 0 Cancer Neurosciences Infectious Diseases Research Category Source: http://report.nih.gov/categorical_spending.aspx 11 NIH Neuroscience Research Other Includes: NIDDK NIAAA NCI FIC 0.03% OTHER 3% 3% 3% TYPE 1 0.01% NINDS 10% NLM 0.02% 27% NIGMS NCMHD 0.05% 3% NCATS 0.14% NHLBI NHGRI 0.26% 4% NIDCR 0.52% NIMH NINR 0.52% 15% NICHD NIAMS 0.59% NIA NEI 4% NCCAM 0.60% 8% 8% NIDCD NIAID 1.06% 4% NIBIB 1.22% NIEHS 1.50% NIDA RMAP 1.64% 8% OD 2.14% Source: http://report.nih.gov/categorical_spending.aspx 12 6 10/26/2015 The Problem Unmet need in hundreds of neurological disorders Chronic Orthostatic Intolerance Globoid Cell Leukodystrophy Metachromatic Leukodystrophy Pinched Nerve Tabes Dorsalis Absence of the Septum Pellucidum Chronic Pain Glossopharyngeal Neuralgia Microcephaly Piriformis Syndrome Tardive Dyskinesia Acquired Epileptiform Aphasia Cockayne Syndrome Type II Guillain-Barre Syndrome Migraine Pituitary Tumors Tarlov Cysts Acute Disseminated Coffin Lowry Syndrome Hallervorden-Spatz Disease Miller Fisher Syndrome Polymyositis Tay-Sachs Disease Encephalomyelitis COFS Head Injury Mini-Strokes Pompe Disease Temporal Arteritis ADHD Coma and Persistent Vegetative Headache Mitochondrial Myopathies Porencephaly Tethered Spinal Cord Syndrome Adrenoleukodystrophy State Hemicrania Continua Mobius Syndrome Postherpetic Neuralgia Thomsen Disease Agenesis of the Corpus Callosum Complex Regional Pain Syndrome Hemifacial Spasm Monomelic Amyotrophy Postinfectious Encephalomyelitis Thoracic Outlet Syndrome Agnosia Congenital Facial Diplegia Hemiplegia Alterans Motor Neuron Diseases Post-Polio Syndrome Thyrotoxic Myopathy Aicardi Syndrome Congenital Myasthenia Hereditary Neuropathies Moyamoya Disease Postural Hypotension Tic Douloureux AIDS - Neurological Complications Congenital Myopathy Hereditary Spastic Paraplegia Mucolipidoses Postural Orthostatic Tachycardia Todd's Paralysis Alexander Disease Congenital Vascular Cavernous Heredopathia Atactica Mucopolysaccharidoses Syndrome Tourette Syndrome Alpers' Disease Malformations Polyneuritiformis Multifocal Motor Neuropathy Postural achycardia Syndrome Transient Ischemic Attack Alternating Hemiplegia Corticobasal Degeneration Herpes Zoster Multi-Infarct Dementia Primary Dentatum Atrophy Transmissible Spongiform Alzheimer's Disease Cranial Arteritis Herpes Zoster Oticus Multiple Sclerosis Primary Lateral Sclerosis Encephalopathies Amyotrophic Lateral Sclerosis Craniosynostosis Hirayama Syndrome Multiple System Atrophy Prion Diseases Transverse Myelitis Anencephaly Creutzfeldt-Jakob Disease Holoprosencephaly Multiple System Atrophy with Progressive Hemifacial Atrophy Traumatic Brain Injury Aneurysm Cumulative Trauma Disorders HTLV-1 Associated Myelopathy Orthostatic Hypotension Progressive Locomotor Ataxia Tremor Angelman Syndrome Cushing's Syndrome Huntington's Disease Muscular Dystrophy Progressive Multifocal Trigeminal Neuralgia Angiomatosis Cytomegalic Inclusion Body Disease Hydranencephaly Myasthenia - Congenital Leukoencephalopathy Tropical Spastic Paraparesis Anoxia (CIBD) Hydrocephalus Myasthenia Gravis Progressive Sclerosing Tuberous Sclerosis Aphasia Cytomegalovirus Infection Hydrocephalus - Normal Pressure Myelinoclastic Diffuse Sclerosis Poliodystrophy Vascular Erectile Tumor Arteriovenous Malformation Dancing Eyes-Dancing Feet Hydromyelia Myoclonic Encephalopathy of Progressive Supranuclear Palsy Vasculitis including Temporal Asperger Syndrome Syndrome Hypercortisolism Infants Pseudotumor Cerebri Arteritis Ataxia Dandy-Walker Syndrome Hypersomnia Myoclonus Ramsay Hunt Syndrome Von Economo’s Disease Ataxia Telangiectasia Dawson Disease Hypertonia Myopathy Ramsay Hunt Syndrome I (formerly Von Hippel-Lindau Disease (VHL) Ataxias and De Morsier's Syndrome Hypotonia - Infantile Myopathy - Congenital known as) Von Recklinghausen's Disease Cerebellar/Spinocerebellar Deep Brain Stimulation for Hypoxia Myopathy - Thyrotoxic Ramsay Hunt Syndrome II Wallenberg's Syndrome Degeneration Parkinson's Disease Immune-Mediated Myotonia Rasmussen's Encephalitis Werdnig-Hoffman Disease Attention Deficit-Hyperactivity Dejerine-Klumpke Palsy Encephalomyelitis Myotonia Congenita Reflex Sympathetic Dystrophy Wernicke-Korsakoff Syndrome Disorder Dementia - Multi-Infarct Inclusion Body Myositis Narcolepsy Syndrome West Syndrome Autism Dementia - Subcortical Incontinentia Pigmenti Neuroacanthocytosis Refsum Disease Whiplash Autonomic Dysfunction Dementia With Lewy Bodies Infantile Hypotonia Neurodegeneration with Brain Iron Refsum Disease - Infantile Whipple's Disease Back Pain Dentate Cerebellar Ataxia Infantile Phytanic Acid Storage Accumulation Repetitive Motion Disorders Williams Syndrome Barth Syndrome Dentatorubral Atrophy Disease Neurofibromatosis Repetitive Stress Injuries Wilson's Disease Batten Disease Dermatomyositis Infantile Refsum Disease Neuroleptic Malignant Syndrome Restless Legs Syndrome X-Linked Spinal and Bulbar Behcet's Disease Developmental Dyspraxia Infantile Spasms Retrovirus-Associated Myelopathy Muscular Atrophy Bell's Palsy Devic's Syndrome Inflammatory Myopathy Neurological Complications of AIDS Rett Syndrome Zellweger Syndrome Benign Essential Blepharospasm Diabetic Neuropathy Intestinal Lipodystrophy Neurological Complications Of Lyme Reye's Syndrome Benign Focal Amyotrophy Diffuse Sclerosis Intracranial Cysts Disease Riley-Day Syndrome Benign Intracranial Hypertension Dysautonomia Intracranial Hypertension Neurological Manifestations of Sacral Nerve Root Cysts Bernhardt-Roth Syndrome Dysgraphia Isaac's Syndrome Pompe Disease Saint Vitus Dance Binswanger's Disease Dyslexia Joubert Syndrome Neurological Sequelae Of Lupus Salivary Gland Disease Blepharospasm Dysphagia Kearns-Sayre Syndrome Neuromyelitis Optica Sandhoff Disease Bloch-Sulzberger Syndrome Dyspraxia Kennedy's Disease Neuromyotonia Schilder's Disease Brachial Plexus Birth Injuries Dyssynergia Cerebellaris Kinsbourne syndrome Neuronal Ceroid Lipofuscinosis Schizencephaly Brachial Plexus Injuries Myoclonica Kleine-Levin Syndrome Neuronal Migration Disorders Seizure Disorder Bradbury-Eggleston Syndrome Dyssynergia Cerebellaris Klippel-Feil Syndrome Neuropathy - Hereditary Septo-Optic Dysplasia Brain and Spinal Tumors Progressiva Klippel-Trenaunay Syndrome (KTS) Neurosarcoidosis Shaken Baby Syndrome Brain Aneurysm Dystonias Klüver-Bucy Syndrome Neurotoxicity Shingles Brain Injury Early Infantile Epileptic Korsakoff's Amnesic Syndrome Nevus Cavernosus Shy-Drager Syndrome Brown-Sequard Syndrome Encephalopathy Krabbe Disease Niemann-Pick Disease Sjogren's Syndrome Bulbospinal Muscular Atrophy Empty Sella Syndrome Kugelberg-Welander Disease Normal Pressure Hydrocephalus Sleep Apnea Canavan Disease Encephalitis and Meningitis Kuru Occipital Neuralgia Sleeping Sickness Carpal Tunnel Syndrome Encephalitis Lethargica Lambert-Eaton Myasthenic Occult Spinal Dysraphism Sequence Soto's Syndrome WWW.NINDS.NIH.GOV Causalgia Encephaloceles Syndrome Ohtahara Syndrome Spasticity Cavernomas Encephalopathy Landau-Kleffner Syndrome Olivopontocerebellar Atrophy Spina Bifida Cavernous Angioma Encephalotrigeminal Angiomatosis Lateral Femoral Cutaneous Nerve Opsoclonus Myoclonus Spinal Cord Infarction Cavernous Malformation Epilepsy Entrapment Orthostatic Hypotension Spinal Cord Injury Central Cervical Cord Syndrome Erb-Duchenne and Dejerine- Lateral Medullary Syndrome O'Sullivan-McLeod Syndrome Spinal Cord Tumors Central Cord Syndrome Klumpke Palsies Learning Disabilities Overuse Syndrome Spinal Muscular Atrophy Central Pain Syndrome Erb's Palsy Leigh's Disease Pain - Chronic Spinocerebellar Atrophy Cephalic Disorders Fabry's Disease Lennox-Gastaut Syndrome Pantothenate Kinase-Associated Spinocerebellar Degeneration Cerebellar Degeneration Fahr's Syndrome Lesch-Nyhan Syndrome Neurodegeneration Steele-Richardson-Olszewski Cerebellar Hypoplasia