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Paean to a Founder of Heredity BOOKS & ARTS COMMENT theory, which Weis- mann set out in the 1880s, rejected AKG-IMAGES the possibility that acquired characteris- tics can be inherited, as propounded by Jean-Baptiste Lamarck in the early nineteenth August Weismann: century. Weismann’s Development, materialistic view of Heredity, and Evolution life provided a new FREDERICK B. understanding of biol- CHURCHILL ogy, in which natural Harvard Univ. Press: selection occurred 2015. between individual organisms, as Charles Darwin held, and with competition at the level of inherited determinants. This influ- enced the nature of the resulting variations. So Weismann, as Churchill makes clear, had one foot in the observational traditions and questions of nineteenth-century natural his- tory — even as he extended the other into the experimental, theoretical twentieth century. August Weismann reveals a scientist who grew up fascinated by nature and worked briefly as a medical doctor, then adjusted to roles as a faculty member at the University of Freiburg in Germany and director of its zoological institute, where he spent most of his career. Weismann looked at butterfly variations in considerable detail to explore patterns of heredity, protozoa to get at reproduction, jellyfish-like hydro­medusae, the planktonic crustaceans Daphnia, and August Weismann, painted by Otto Scholderer in 1896. frogs — whatever it took to study the rel- evant phenomena. In 1862, while living at EVOLUTIONARY BIOLOGY the isolated Schaumburg Palace as personal physician to Archduke Stephan of Austria for a year, he also explored natural his- tory, especially of insects. The experience Paean to a founder re­inforced Weismann’s determination to pursue biological research rather than med- icine, and he moved to Freiburg, where he took on a series of research positions. of heredity He increasingly turned to microscopy, experimental embryology and cytology to look deep into an organism to see changes Jane Maienschein applauds a study of towering in the cells and nucleus. At the Freiburg nineteenth-century biologist August Weismann. zoological institute, Weismann relied on his own observations and those of his students and assistants — both in the spirit of col- monumental study of an important these days is awe-inspiring. When Churchill laboration and to compensate for his failing but surprisingly little-studied biolo- was my PhD supervisor in the 1970s, he eyesight. gist, August Weismann represents warned me not to take on too large a disser- Throughout, Weismann insisted that Ahalf a century of scholarly investment by tation topic, given the dearth of jobs and the development, heredity and evolution are historian of science Frederick Churchill. pressures to move results into print quickly. interconnected and must be studied as Churchill immersed himself in the observa- The history of science is richer for his not such. As he saw it, biologists should seek tions and experiments, people, institutions having heeded his own advice. the underlying chemical and physical and ideas of the nineteenth and early twen- Weismann’s great contribution was the mechanisms. So while tieth centuries — an astoundingly fertile era idea that germ-plasm — the name that he NATURE.COM his contemporaries for the biological sciences — as well as in all of gave to the essential element of gametes, or For more on science focused on details the many books and articles that Weismann eggs and sperm — carries the mat­erial of in culture, see: of cells, chromo- (1834–1914) wrote, in German and English. heredity from one generation to the next, nature.com/ somes or evolution- That anybody can write this kind of book unaffected by the environment. Germ-plasm booksandarts ary mechanisms, 4 JUNE 2015 | VOL 522 | NATURE | 31 © 2015 Macmillan Publishers Limited. All rights reserved COMMENT BOOKS & ARTS Weismann sought to illuminate the links between them. Churchill shows how Weismann’s experimental observations of chromo- some movements during cell division reinforced his germ-plasm theory. Weismann adapted ideas from leading cytologists and experimental embry- ologists such as Theodor Boveri and Wilhelm Roux, to link heredity and development through what Churchill calls his “architectonic view”. Instead of a holistic or vitalistic understanding of the organism, Weismann developed a more structural view in which the system depends on integration of the material parts, with guidance from the germ- plasm and its determinants. Develop- ment then constructs the organism out of cells, with reproduction providing a source of variation on which natural selection acts, enabling evolution. Weismann was confident and some- times controversial. Churchill shows how disagreements helped Weismann The hybrid dinosaur Indominus rex runs rampant in Jurassic World. to work out his own ideas. He sparred, for example, with physician and biologist Rudolf Virchow over issues of acquired characteristics and the role of external Q&A Jack Horner factors in shaping variation. And Weis- mann clashed with zoologist Theodor Eimer about the apparent randomness of evolution. Dozens of leading scientists The dinosaur doctor influenced or interacted with Weismann Montana palaeontologist Jack Horner has served as scientific adviser on the Jurassic Park films because of his central role in biology. The from the start. With the latest, Jurassic World, soon to be released, he talks about a shark- zoologist and illustrator Ernst Haeckel, devouring Mosasaurus, breeding chickens back into dinosaurs and the influence of the film for example, was a close friend, but his franchise on his own field. views diverged from Weismann’s in ways that influenced both men, and affected public perceptions of biology. We also see How did you get on its toes in a bird-like position, rather than the impact on Weismann of technically involved in the series? heel-first like a mammal. In a kitchen scene, brilliant figures such as Boveri and theo- In the early 1990s, a the puppeteers had velociraptors sticking out reticians including Darwin. Weismann in colleague called me forked tongues, which dinosaurs did not have. turn influenced his contemporaries and and said, “You’re in a Instead, we had the raptors snort to fog up the subsequent generations of Darwinians. book about cloning window, revealing that they had warm blood. Even as his contemporaries began to dinosaurs” — Michael MUS. OF THE ROCKIES LEFT: specialize and to give up the study of con- Crichton’s Jurassic What are the innovations in Jurassic World? nections between heredity, development Park (Alfred A. Knopf, The science has got ahead of the films, but we and evolution in favour of specialized 1990). I said, “I hope my character doesn’t get cannot really change the way the dinosaurs study of the parts or selected processes, eaten.” I never bothered to pick it up; I am look. If suddenly the raptors had feathers, it Weismann worked hard to develop a dyslexic and have trouble enough keeping up would destroy consistency. But I did help to comprehensive understanding of life. with my own science. Then director Steven render new creatures. You can see a mosasaur, ENTERTAINMENT; UNIVERSAL PICTURES/AMBLIN TOP: Churchill has mirrored that determina- Spielberg called and asked whether I wanted a giant swimming reptile, shoot up from a tion in developing a compelling and com- to work on the film. I thought growing a dino- tank to eat a great white shark. From my prehensive understanding of Weismann, saur was an intriguing idea, and I still do. It is research, I helped to ensure that the juvenile his ideas, work, life, contemporaries and a little far-fetched now, but I think one day we triceratops, with its backward-curving horns, context. ■ will be able to do it, not using amber-trapped looked distinct from the adult, whose horns DNA, but through genetic modification of curve forward. But my biggest job was helping Jane Maienschein is Regents’, President’s dinosaurs’ closest living relatives, birds. to create the ‘genetically modified’ Indominus and Parents Association Professor at rex, a combination of several dinosaurs and Arizona State University in Tempe, and What did work on Jurassic Park (1993) entail? other animals, which turns against its makers. adjunct senior scientist at the Marine My job was to find things that were obviously Biological Laboratory in Woods Hole, wrong. In one scene, the puppeteers were hav- How plausible is such a dino-hybrid? Massachusetts. Her most recent book is ing trouble getting an animatronic Tyranno- Jurassic World is set in the future. If you can Embryos Under the Microscope. saurus rex leg to move properly. So I stepped clone a dinosaur, you can modify its DNA e-mail: [email protected] in to control the joystick, making the foot land and combine it with that of other animals. We 32 | NATURE | VOL 522 | 4 JUNE 2015 © 2015 Macmillan Publishers Limited. All rights reserved.
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